                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  Bispecific T cell activating antigen binding molecules

<130>  30599

<150>  EP 11178369.2
<151>  2011-08-23

<160>  117   

<170>  PatentIn version 3.5

<210>  1
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 (VL-VH)-V9 (VH-VL)-Fc(knob) P329G LALA

<400>  1

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile 
145                 150                 155                 160 


Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr 
                165                 170                 175     


Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile 
            180                 185                 190         


Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys Leu Asn Ser Val 
        195                 200                 205             


Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Asp Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Glu 
225                 230                 235                 240 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                245                 250                 255     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
            260                 265                 270         


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        275                 280                 285             


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
    290                 295                 300                 


Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu 
305                 310                 315                 320 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                325                 330                 335     


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            340                 345                 350         


Gln Gly Thr Leu Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Met Thr 
    370                 375                 380                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
385                 390                 395                 400 


Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 
                405                 410                 415     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
            420                 425                 430         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        435                 440                 445             


Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    450                 455                 460                 


Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly 
465                 470                 475                 480 


Thr Lys Val Glu Ile Lys Arg Thr Asp Lys Thr His Thr Cys Pro Pro 
                485                 490                 495     


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
            500                 505                 510         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        515                 520                 525             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    530                 535                 540                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
545                 550                 555                 560 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                565                 570                 575     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            580                 585                 590         


Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        595                 600                 605             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
    610                 615                 620                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
625                 630                 635                 640 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                645                 650                 655     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            660                 665                 670         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        675                 680                 685             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    690                 695                 700                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715 


<210>  2
<211>  2148
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 (VL-VH)-V9 (VH-VL)-Fc(knob) P329G LALA

<400>  2
gacatcgtgc tgacccagag ccccagcagc ctgagcgcca gcctgggcga cagagtgacc       60

atcagctgca gcgcctccca gggcatcaga aactacctga actggtatca gcagcggccc      120

gacggcaccg tgaagctgct gatctactac accagctccc tgcacagcgg cgtgcccagc      180

agattttcag gcagcggcag cggcactgac tacagcctga ccatctccaa cctggaaccc      240

gaggacattg ccacctacta ctgccagcag tacagcaagc tgccctggac cttcggcgga      300

ggcaccaagc tggaaatcaa gggcggaggc ggatccggcg gaggtggaag tggcggcgga      360

ggctctgagg tgcaattgca ggaaagcggc cctggcctgg tgaaacccag ccagagcctg      420

agcctgacct gcagcgtgac cggctactcc atcaccagcg gctactactg gaactggatc      480

agacagttcc ccggaaacaa gctggaatgg atgggttaca tcacctacga cggcagcaac      540

aactacaacc ccagcctgaa gaaccggatc agcatcaccc gggacaccag caagaaccag      600

ttcttcctga agctgaacag cgtgaccacc gaggataccg ccacctatta ctgtgccgac      660

ttcgactact ggggccaggg caccaccctg accgtgtcat ccggtggcgg cggatccgaa      720

gtgcagctgg tggagtctgg cggtggactg gtgcagccag gcggctccct gagactgagc      780

tgcgccgcct ccggctacag cttcaccggc tacaccatga attgggtccg ccaggcccct      840

ggaaagggac tggaatgggt ggccctgatc aacccctaca agggcgtgag cacctacaac      900

cagaagttca aggaccggtt caccatcagc gtggacaaga gcaagaacac agcctacctg      960

cagatgaact ccctgagagc cgaggatacc gccgtgtatt actgtgcccg cagcggctac     1020

tacggcgact ccgactggta cttcgacgtg tgggggcagg gaaccctggt caccgtgtcc     1080

agcgtggaag gcggcagcgg aggatctggc ggctctggcg gaagcggcgg agtggacgat     1140

atccagatga cacagtcccc cagctccctg agcgccagcg tgggcgacag agtgaccatc     1200

acctgtcggg ccagccagga catccggaat tatctcaatt ggtatcagca gaaacctggc     1260

aaagctccta aactgctgat ctactacacc tcccggctgg aaagcggcgt gcccagcaga     1320

ttttccggca gcgggagcgg caccgattac acactgacca tcagcagcct gcagcccgag     1380

gactttgcca cctactattg ccagcagggc aacaccctgc cctggacctt tgggcagggc     1440

acaaaggtgg agatcaagcg tacggacaaa actcacacat gcccaccgtg cccagcacct     1500

gaagctgcag ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     1560

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     1620

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1680

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1740

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctcgg cgcccccatc     1800

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1860

ccatgccggg atgagctgac caagaaccag gtcagcctgt ggtgcctggt caaaggcttc     1920

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1980

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     2040

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     2100

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  2148


<210>  3
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 (VL-VH S-S)-V9 (VH-VL S-S)-Fc(knob) P329G LALA

<400>  3

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile 
145                 150                 155                 160 


Arg Gln Phe Pro Gly Asn Cys Leu Glu Trp Met Gly Tyr Ile Thr Tyr 
                165                 170                 175     


Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile 
            180                 185                 190         


Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys Leu Asn Ser Val 
        195                 200                 205             


Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Asp Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Glu 
225                 230                 235                 240 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                245                 250                 255     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
            260                 265                 270         


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
        275                 280                 285             


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
    290                 295                 300                 


Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu 
305                 310                 315                 320 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                325                 330                 335     


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            340                 345                 350         


Gln Gly Thr Leu Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Met Thr 
    370                 375                 380                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
385                 390                 395                 400 


Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 
                405                 410                 415     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
            420                 425                 430         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        435                 440                 445             


Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    450                 455                 460                 


Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Cys Gly 
465                 470                 475                 480 


Thr Lys Val Glu Ile Lys Arg Thr Asp Lys Thr His Thr Cys Pro Pro 
                485                 490                 495     


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
            500                 505                 510         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        515                 520                 525             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    530                 535                 540                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
545                 550                 555                 560 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                565                 570                 575     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            580                 585                 590         


Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        595                 600                 605             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
    610                 615                 620                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
625                 630                 635                 640 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                645                 650                 655     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            660                 665                 670         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        675                 680                 685             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    690                 695                 700                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715 


<210>  4
<211>  2148
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 (VL-VH S-S)-V9 (VH-VL S-S)-Fc(knob) P329G LALA

<400>  4
gacatcgtgc tgacccagag ccccagcagc ctgagcgcca gcctgggcga cagagtgacc       60

atcagctgca gcgcctccca gggcatcaga aactacctga actggtatca gcagcggccc      120

gacggcaccg tgaagctgct gatctactac accagctccc tgcacagcgg cgtgcccagc      180

agattttcag gcagcggcag cggcactgac tacagcctga ccatctccaa cctggaaccc      240

gaggacattg ccacctacta ctgccagcag tacagcaagc tgccctggac cttcggctgc      300

ggcaccaagc tggaaatcaa gggcggaggc ggatccggcg gaggtggaag tggcggcgga      360

ggctctgagg tgcaattgca ggaaagcggc cctggcctgg tgaaacccag ccagagcctg      420

agcctgacct gcagcgtgac cggctactcc atcaccagcg gctactactg gaactggatc      480

agacagttcc ccggaaactg tctggaatgg atgggttaca tcacctacga cggcagcaac      540

aactacaacc ccagcctgaa gaaccggatc agcatcaccc gggacaccag caagaaccag      600

ttcttcctga agctgaacag cgtgaccacc gaggataccg ccacctatta ctgtgccgac      660

ttcgactact ggggccaggg caccaccctg accgtgtcat ccggtggcgg cggatccgaa      720

gtgcagctgg tggagtctgg cggtggactg gtgcagccag gcggctccct gagactgagc      780

tgcgccgcct ccggctacag cttcaccggc tacaccatga attgggtccg ccaggcccct      840

ggaaagtgtc tggaatgggt ggccctgatc aacccctaca agggcgtgag cacctacaac      900

cagaagttca aggaccggtt caccatcagc gtggacaaga gcaagaacac agcctacctg      960

cagatgaact ccctgagagc cgaggatacc gccgtgtatt actgtgcccg cagcggctac     1020

tacggcgact ccgactggta cttcgacgtg tgggggcagg gaaccctggt caccgtgtcc     1080

agcgtggaag gcggcagcgg aggatctggc ggctctggcg gaagcggcgg agtggacgat     1140

atccagatga cacagtcccc cagctccctg agcgccagcg tgggcgacag agtgaccatc     1200

acctgtcggg ccagccagga catccggaat tatctcaatt ggtatcagca gaaacctggc     1260

aaagctccta aactgctgat ctactacacc tcccggctgg aaagcggcgt gcccagcaga     1320

ttttccggca gcgggagcgg caccgattac acactgacca tcagcagcct gcagcccgag     1380

gactttgcca cctactattg ccagcagggc aacaccctgc cctggacctt cggctgcggc     1440

acaaaggtgg agatcaagcg tacggacaaa actcacacat gcccaccgtg cccagcacct     1500

gaagctgcag ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     1560

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     1620

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1680

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1740

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctcgg cgcccccatc     1800

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1860

ccatgccggg atgagctgac caagaaccag gtcagcctgt ggtgcctggt caaaggcttc     1920

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1980

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     2040

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     2100

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  2148


<210>  5
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 (VL-VH)-V9 (VH-VL)-Fc(knob) P329G LALA

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
        115                 120                 125             


Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Thr Asp Tyr Lys Ile His Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro Asn Ser 
                165                 170                 175     


Gly Tyr Ser Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr 
            180                 185                 190         


Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
        195                 200                 205             


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser Pro Gly Gly 
    210                 215                 220                 


Tyr Tyr Val Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser 
    290                 295                 300                 


Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys 
305                 310                 315                 320 


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                325                 330                 335     


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp 
            340                 345                 350         


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             


Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Val Asp Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
385                 390                 395                 400 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg 
                405                 410                 415     


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            420                 425                 430         


Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe 
        435                 440                 445             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
    450                 455                 460                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu 
465                 470                 475                 480 


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Asp 
                485                 490                 495     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            500                 505                 510         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        515                 520                 525             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    530                 535                 540                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
545                 550                 555                 560 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                565                 570                 575     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            580                 585                 590         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
        595                 600                 605             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    610                 615                 620                 


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
625                 630                 635                 640 


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                645                 650                 655     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            660                 665                 670         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        675                 680                 685             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    690                 695                 700                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
705                 710                 715                 720 


Gly Lys 
        


<210>  6
<211>  2169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 (VL-VH)-V9 (VH-VL)-Fc(knob) P329G LALA

<400>  6
gatattcaga tgacccagag cccgagcagc ctgagcgcaa gcgttggtga tcgtgttacc       60

attacctgtc gtgcaagcca gggtattaat aactatctga attggtatca gcagaaaccg      120

ggtaaagcac cgaaacgtct gatttataac accaataatc tgcagaccgg tgttccgagc      180

cgttttagcg gtagcggttc tggcaccgaa tttaccctga ccattagcag cctgcagccg      240

gaagattttg caacctatta ttgcctgcag cataatagct ttccgacctt tggccagggc      300

accaaactgg aaattaaagg tggtggtggt agcggtggtg gtggctctgg tggcggtggt      360

agccaggttc agctggttca gagcggtgca gaagttaaaa aaccgggtag cagcgttaaa      420

gttagctgta aagccagcgg ttttaccttt accgattata aaattcattg ggttcgccag      480

gcaccgggtc agggtctgga atggatgggt tattttaatc cgaatagcgg ttatagcacc      540

tatgcacaga aatttcaggg tcgcgtgacc attaccgcag ataaaagcac cagcaccgca      600

tatatggaac tgagcagcct gcgtagcgaa gataccgcag tttattattg tgcacgtctg      660

tctccgggtg gttattatgt tatggatgca tggggtcagg gcaccaccgt taccgttagc      720

agcggtggcg gcggatccga agtgcagctg gtggagtctg gcggtggact ggtgcagcca      780

ggcggctccc tgagactgag ctgcgccgcc tccggctaca gcttcaccgg ctacaccatg      840

aattgggtcc gccaggcccc tggaaaggga ctggaatggg tggccctgat caacccctac      900

aagggcgtga gcacctacaa ccagaagttc aaggaccggt tcaccatcag cgtggacaag      960

agcaagaaca cagcctacct gcagatgaac tccctgagag ccgaggatac cgccgtgtat     1020

tactgtgccc gcagcggcta ctacggcgac tccgactggt acttcgacgt gtgggggcag     1080

ggaaccctgg tcaccgtgtc cagcgtggaa ggcggcagcg gaggatctgg cggctctggc     1140

ggaagcggcg gagtggacga tatccagatg acacagtccc ccagctccct gagcgccagc     1200

gtgggcgaca gagtgaccat cacctgtcgg gccagccagg acatccggaa ttatctcaat     1260

tggtatcagc agaaacctgg caaagctcct aaactgctga tctactacac ctcccggctg     1320

gaaagcggcg tgcccagcag attttccggc agcgggagcg gcaccgatta cacactgacc     1380

atcagcagcc tgcagcccga ggactttgcc acctactatt gccagcaggg caacaccctg     1440

ccctggacct ttgggcaggg cacaaaggtg gagatcaagc gtacggacaa aactcacaca     1500

tgcccaccgt gcccagcacc tgaagctgca gggggaccgt cagtcttcct cttcccccca     1560

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1620

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1680

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1740

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1800

aaagccctcg gcgcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1860

ccacaggtgt acaccctgcc cccatgccgg gatgagctga ccaagaacca ggtcagcctg     1920

tggtgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1980

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2040

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2100

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2160

ggtaaatga                                                             2169


<210>  7
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 (VL-VH)-V9 (VH-VL)-Fc(knob) P329G LALA

<400>  7

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
    130                 135                 140                 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser Asn Ile 
145                 150                 155                 160 


His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile Gly Tyr 
                165                 170                 175     


Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe Lys Asn 
            180                 185                 190         


Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys Val Asn 
    210                 215                 220                 


Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val 
    290                 295                 300                 


Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp 
305                 310                 315                 320 


Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
                325                 330                 335     


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser 
            340                 345                 350         


Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        355                 360                 365             


Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Val Asp Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
385                 390                 395                 400 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
                405                 410                 415     


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            420                 425                 430         


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg 
        435                 440                 445             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
    450                 455                 460                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr 
465                 470                 475                 480 


Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
                485                 490                 495     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            500                 505                 510         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        515                 520                 525             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    530                 535                 540                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
545                 550                 555                 560 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                565                 570                 575     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            580                 585                 590         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
        595                 600                 605             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    610                 615                 620                 


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
625                 630                 635                 640 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                645                 650                 655     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            660                 665                 670         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        675                 680                 685             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    690                 695                 700                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
705                 710                 715                 720 


Pro Gly Lys 
            


<210>  8
<211>  2172
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD33 (VL-VH)-V9 (VH-VL)-Fc(knob) P329G LALA

<400>  8
gacatccagc tgacccagag ccccagcacc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcga gagcctggac aactacggca tccggtttct gacctggttc      120

cagcagaagc ccggcaaggc ccccaagctg ctgatgtacg ccgccagcaa ccagggcagc      180

ggcgtgccaa gcagattcag cggcagcggc tccggcaccg agttcaccct gaccatcagc      240

agcctgcagc ccgacgactt cgccacctac tactgccagc agaccaaaga ggtgccctgg      300

tccttcggcc agggcaccaa ggtggaagtg aagggcggag gcggctctgg cggtggagga      360

tctggcggag ggggaagtga agtgcagctg gtgcagtctg gcgccgaagt gaagaaaccc      420

ggcagcagcg tgaaggtgtc ctgcaaggcc agcggctaca ccatcaccga cagcaacatc      480

cactgggtcc gacaggcccc tgggcagagc ctggaatgga tcggctacat ctacccctac      540

aacggcggca ccgactacaa ccagaagttc aagaaccggg ccaccctgac cgtggacaac      600

cccaccaaca ccgcctacat ggaactgagc agcctgcgga gcgaggacac cgccttctac      660

tactgcgtga acggcaaccc ctggctggcc tattggggcc agggaaccct ggtcaccgtg      720

tctagcggag gcgggggatc cgaagtgcag ctggtggagt ctggcggtgg actggtgcag      780

ccaggcggct ccctgagact gagctgcgcc gcctccggct acagcttcac cggctacacc      840

atgaattggg tccgccaggc ccctggaaag ggactggaat gggtggccct gatcaacccc      900

tacaagggcg tgagcaccta caaccagaag ttcaaggacc ggttcaccat cagcgtggac      960

aagagcaaga acacagccta cctgcagatg aactccctga gagccgagga taccgccgtg     1020

tattactgtg cccgcagcgg ctactacggc gactccgact ggtacttcga cgtgtggggg     1080

cagggaaccc tggtcaccgt gtccagcgtg gaaggcggca gcggaggatc tggcggctct     1140

ggcggaagcg gcggagtgga cgatatccag atgacacagt cccccagctc cctgagcgcc     1200

agcgtgggcg acagagtgac catcacctgt cgggccagcc aggacatccg gaattatctc     1260

aattggtatc agcagaaacc tggcaaagct cctaaactgc tgatctacta cacctcccgg     1320

ctggaaagcg gcgtgcccag cagattttcc ggcagcggga gcggcaccga ttacacactg     1380

accatcagca gcctgcagcc cgaggacttt gccacctact attgccagca gggcaacacc     1440

ctgccctgga cctttgggca gggcacaaag gtggagatca agcgtacgga caaaactcac     1500

acatgcccac cgtgcccagc acctgaagct gcagggggac cgtcagtctt cctcttcccc     1560

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     1620

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1680

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1740

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1800

aacaaagccc tcggcgcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1860

gaaccacagg tgtacaccct gcccccatgc cgggatgagc tgaccaagaa ccaggtcagc     1920

ctgtggtgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1980

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     2040

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     2100

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     2160

ccgggtaaat ga                                                         2172


<210>  9
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(hole) P329G LALA

<400>  9

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  10
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(hole) P329G LALA

<400>  10
gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa atga                                             684


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR1

<400>  11

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn 
1               5                   10      


<210>  12
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR1

<400>  12
ggctactcca tcaccagtgg ttattactgg aac                                    33


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR2

<400>  13

Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  14
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR2

<400>  14
tacataacct acgacggtag caataactac aacccatctc tcaaaaat                    48


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR3

<400>  15

Phe Asp Tyr 
1           


<210>  16
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR3

<400>  16
tttgactac                                                                9


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 VH

<400>  17

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  18
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 VH

<400>  18
gaggtccagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaagctgga atggatgggc tacataacct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc ggactttgac      300

tactggggcc aaggcaccac tctcacagtc tcctca                                336


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR1

<400>  19

Ser Ala Ser Gln Gly Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  20
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR1

<400>  20
agtgcaagtc agggcattag aaattattta aac                                    33


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR2

<400>  21

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR2

<400>  22
tacacatcaa gtttacactc a                                                 21


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR3

<400>  23

Gln Gln Tyr Ser Lys Leu Pro Trp Thr 
1               5                   


<210>  24
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR3

<400>  24
cagcagtata gtaagcttcc ttggacg                                           27


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 VL

<400>  25

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 VL

<400>  26
gatattgtgc tcacacagtc tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattaga aattatttaa actggtatca gcagagacca      120

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR1

<400>  27

Asp Tyr Lys Ile His 
1               5   


<210>  28
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR1

<400>  28
gactacaaga tacac                                                        15


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR2

<400>  29

Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR2

<400>  30
tatttcaacc ctaacagcgg ttatagtacc tacgcacaga agttccaggg c                51


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR3

<400>  31

Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala 
1               5                   10      


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR3

<400>  32
ctatccccag gcggttacta tgttatggat gcc                                    33


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 VH

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Lys Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 VH

<400>  34
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggttt cacattcact gactacaaga tacactgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggatat ttcaacccta acagcggtta tagtacctac      180

gcacagaagt tccagggcag ggtcaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagactatcc      300

ccaggcggtt actatgttat ggatgcctgg ggccaaggga ccaccgtgac cgtctcctca      360


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR1

<400>  35

Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  36
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR1

<400>  36
cgggcaagtc agggcattaa caattactta aat                                    33


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR2

<400>  37

Asn Thr Asn Asn Leu Gln Thr 
1               5           


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR2

<400>  38
aataccaaca acttgcagac a                                                 21


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR3

<400>  39

Leu Gln His Asn Ser Phe Pro Thr 
1               5               


<210>  40
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR3

<400>  40
ttgcagcata atagttttcc cacg                                              24


<210>  41
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 VL

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  42
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 VL

<400>  42
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaac aattacttaa attggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctataat accaacaact tgcagacagg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gaagattttg ccacctatta ctgcttgcag cataatagtt ttcccacgtt tggccagggc      300

accaagctcg agatcaag                                                    318


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR1

<400>  43

Ser Tyr Ala Met Ser 
1               5   


<210>  44
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR1

<400>  44
agctacgcca tgagc                                                        15


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR2

<400>  45

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  46
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR2

<400>  46
gccatctccg gcagcggagg cagcacctac tacgccgaca gcgtgaag                    48


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR3

<400>  47

Tyr Cys Ala Lys Gly Trp Phe Gly 
1               5               


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR3

<400>  48
tattgcgcca agggatggtt cggc                                              24


<210>  49
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 VH

<400>  49

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  50
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 VH

<400>  50
gaggtgcagc tgctggaatc tggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaagg gactggaatg ggtgtccgcc atctccggca gcggaggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agcagagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgccgtgt attattgcgc caagggatgg      300

ttcggcggct tcaactactg gggccaggga accctggtga cagtgtccag c               351


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR1

<400>  51

Arg Ala Ser Gln Ser Val Thr Ser Ser Tyr Leu 
1               5                   10      


<210>  52
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR1

<400>  52
agagccagcc agagcgtgac cagcagctac ctg                                    33


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR2

<400>  53

Asn Val Gly Ser Arg Arg Ala 
1               5           


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR2

<400>  54
aacgtgggca gcagacgggc c                                                 21


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR3

<400>  55

Cys Gln Gln Gly Ile Met Leu Pro Pro 
1               5                   


<210>  56
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR3

<400>  56
tgccagcagg gcatcatgct gcccccc                                           27


<210>  57
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 VL

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  58
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 VL

<400>  58
gagatcgtgc tgacccagtc tcccggcacc ctgagcctga gccctggcga gagagccacc       60

ctgagctgca gagccagcca gagcgtgacc agcagctacc tggcctggta tcagcagaag      120

cccggccagg cccccagact gctgatcaac gtgggcagca gacgggccac cggcatcccc      180

gatagattca gcggcagcgg ctccggcacc gacttcaccc tgaccatcag ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagggcatca tgctgccccc caccttcggc      300

cagggcacca aggtggaaat caag                                             324


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR1

<400>  59

Glu Phe Gly Met Asn 
1               5   


<210>  60
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR1

<400>  60
gagttcggca tgaac                                                        15


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR2

<400>  61

Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR2

<400>  62
tggatcaaca ccaagaccgg cgaggccacc tacgtggaag agttcaaggg c                51


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR3

<400>  63

Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  64
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR3

<400>  64
tgggacttcg cctattacgt ggaagccatg gactac                                 36


<210>  65
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A VH

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  66
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A VH

<400>  66
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  67
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR1

<400>  67

Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala 
1               5                   10      


<210>  68
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR1

<400>  68
aaggccagtg cggctgtggg tacgtatgtt gcg                                    33


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR2

<400>  69

Ser Ala Ser Tyr Arg Lys Arg 
1               5           


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR2

<400>  70
tcggcatcct accgcaaaag g                                                 21


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR3

<400>  71

His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr 
1               5                   10  


<210>  72
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR3

<400>  72
caccaatatt acacctatcc tctattcacg                                        30


<210>  73
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A VL

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  74
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A VL

<400>  74
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caag                                             324


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR1

<400>  75

Gly Tyr Thr Ile Thr Asp Ser Asn Ile His 
1               5                   10  


<210>  76
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR1

<400>  76
ggctacacca tcaccgacag caacatccac                                        30


<210>  77
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR2

<400>  77

Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln 
1               5                   10              


<210>  78
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR2

<400>  78
tacatctacc cctacaacgg cggcaccgac tacaaccag                              39


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR3

<400>  79

Gly Asn Pro Trp Leu Ala Tyr 
1               5           


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR3

<400>  80
ggcaacccct ggctggccta t                                                 21


<210>  81
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VH

<400>  81

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  82
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VH

<400>  82
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggcagcag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccatcacc gacagcaaca tccactgggt ccgacaggcc      120

cctgggcaga gcctggaatg gatcggctac atctacccct acaacggcgg caccgactac      180

aaccagaagt tcaagaaccg ggccaccctg accgtggaca accccaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccttct actactgcgt gaacggcaac      300

ccctggctgg cctattgggg ccagggaacc ctggtcaccg tgtctagc                   348


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR1

<400>  83

Arg Ala Ser Glu Ser Leu Asp Asn Tyr Gly Ile Arg Phe Leu Thr 
1               5                   10                  15  


<210>  84
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR1

<400>  84
cgggccagcg agagcctgga caactacggc atccggtttc tgacc                       45


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR2

<400>  85

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR2

<400>  86
gccgccagca accagggcag c                                                 21


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR3

<400>  87

Gln Gln Thr Lys Glu Val Pro Trp Ser 
1               5                   


<210>  88
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR3

<400>  88
cagcagacca aagaggtgcc ctggtcc                                           27


<210>  89
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VL

<400>  89

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105                 110     


<210>  90
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VL

<400>  90
gacatccagc tgacccagag ccccagcacc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcga gagcctggac aactacggca tccggtttct gacctggttc      120

cagcagaagc ccggcaaggc ccccaagctg ctgatgtacg ccgccagcaa ccagggcagc      180

ggcgtgccaa gcagattcag cggcagcggc tccggcaccg agttcaccct gaccatcagc      240

agcctgcagc ccgacgactt cgccacctac tactgccagc agaccaaaga ggtgccctgg      300

tccttcggcc agggcaccaa ggtggaagtg aag                                   333


<210>  91
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  91

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  92
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  92

Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Val Asp 
        


<210>  93
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader 1

<400>  93

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  94
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 1

<400>  94
atggactgga cctggagaat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  95
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 1

<400>  95
atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  96
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader 2

<400>  96

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys 
            20          


<210>  97
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 2

<400>  97
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc       60

aggtgt                                                                  66


<210>  98
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader 3

<400>  98

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  99
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 3

<400>  99
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcc          57


<210>  100
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 3

<400>  100
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccactggagt gcattcc          57


<210>  101
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 3

<400>  101
atgggctggt cctgcatcat cctgtttctg gtcgccacag ccaccggcgt gcactct          57


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 HCDR1

<400>  102

Gly Tyr Thr Met Asn 
1               5   


<210>  103
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 HCDR1

<400>  103
ggctacacca tgaac                                                        15


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 HCDR2

<400>  104

Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  105
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 HCDR2

<400>  105
ctgatcaacc cctacaaggg cgtgagcacc tacaaccaga agttcaagga c                51


<210>  106
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 HCDR3

<400>  106

Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val 
1               5                   10              


<210>  107
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 HCDR3

<400>  107
agcggctact acggcgacag cgactggtac ttcgacgtg                              39


<210>  108
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 VH

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  109
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 VH

<400>  109
gaggtgcagc tggtcgagtc cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggcta cagcttcacc ggctacacca tgaactgggt ccggcaggct      120

cctggcaagg gcctcgaatg ggtggccctg atcaacccct acaagggcgt gagcacctac      180

aaccagaagt tcaaggaccg gttcaccatc agcgtggaca agagcaagaa caccgcctat      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaagcggc      300

tactacggcg acagcgactg gtacttcgac gtgtggggcc agggcacact ggtcaccgtg      360

tccagc                                                                 366


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 LCDR1

<400>  110

Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  111
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 LCDR1

<400>  111
cgggccagcc aggacatcag aaactacctg aac                                    33


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 LCDR2

<400>  112

Tyr Thr Ser Arg Leu Glu Ser 
1               5           


<210>  113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 LCDR2

<400>  113
tacacctcta gactggaaag c                                                 21


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 LCDR3

<400>  114

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  115
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 LCDR3

<400>  115
cagcagggca acacactccc ctggacc                                           27


<210>  116
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 VL

<400>  116

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  117
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 VL

<400>  117
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa g                                                321


