                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  FC FREE ANTIBODIES COMPRISING TWO FAB FRAGMENTS AND METHODS OF 
       USE

<130>  30600

<150>  EP11178391.6
<151>  2011-08-23

<160>  162  

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL MCSP

<400>  1

Ser Ala Ser Gln Gly Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL MCSP

<400>  2

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL MCSP

<400>  3

Gln Gln Tyr Ser Lys Leu Pro Trp Thr 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH MCSP

<400>  4

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn 
1               5                   10      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH MCSP

<400>  5

Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  6
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3  VH MCSP

<400>  6

Phe Asp Tyr 
1           


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL CD3

<400>  7

Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL CD3

<400>  8

Tyr Thr Ser Arg Leu Glu Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL CD3

<400>  9

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH CD3

<400>  10

Gly Tyr Thr Met Asn 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH CD3

<400>  11

Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH CD3

<400>  12

Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val 
1               5                   10              


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL MCSP

<400>  13

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH MCSP

<400>  14

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL MCSP

<400>  15

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  16
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1 MCSP

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp 
            100                 


<210>  17
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIGHT CHAIN MCSP

<400>  17

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  18
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEAVY CHAIN MCSP

<400>  18

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215     


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CD3 (V9)

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  20
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CD3 (V9)

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  21
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL CD3 (V9)

<400>  21

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
1               5                   10                  15      


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            20                  25                  30          


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        35                  40                  45              


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
65                  70                  75                  80  


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                85                  90                  95      


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105 


<210>  22
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1 CD3 (V9)

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys 
            100             


<210>  23
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CD3 (VHCL) (V9)

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys 
225                 


<210>  24
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CD3 (VLCH1) V9

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys 
    210         


<210>  25
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAB (MCSP)-XFAB (CD3)

<400>  25

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
225                 230                 235                 240 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg 
                245                 250                 255     


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            260                 265                 270         


Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe 
        275                 280                 285             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
    290                 295                 300                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu 
305                 310                 315                 320 


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala 
                325                 330                 335     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            340                 345                 350         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        355                 360                 365             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    370                 375                 380                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
385                 390                 395                 400 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                405                 410                 415     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            420                 425                 430         


Val Glu Pro Lys Ser Cys 
        435             


<210>  26
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAB (MCSP)-FAB (MCSP)-XFAB (CD3)

<400>  26

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
225                 230                 235                 240 


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
                245                 250                 255     


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
            260                 265                 270         


Glu Trp Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
        275                 280                 285             


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
    290                 295                 300                 


Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
305                 310                 315                 320 


Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                325                 330                 335     


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
            340                 345                 350         


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
        355                 360                 365             


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
    370                 375                 380                 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
385                 390                 395                 400 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
                405                 410                 415     


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
            420                 425                 430         


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    450                 455                 460                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
465                 470                 475                 480 


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                485                 490                 495     


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser 
            500                 505                 510         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
        515                 520                 525             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn 
    530                 535                 540                 


Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser 
545                 550                 555                 560 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                565                 570                 575     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            580                 585                 590         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        595                 600                 605             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    610                 615                 620                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
625                 630                 635                 640 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                645                 650                 655     


Lys Lys Val Glu Pro Lys Ser Cys 
            660                 


<210>  27
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAB (MCSP)-XFAB (CD3)-FAB (MCSP)

<400>  27

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
225                 230                 235                 240 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg 
                245                 250                 255     


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            260                 265                 270         


Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe 
        275                 280                 285             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
    290                 295                 300                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu 
305                 310                 315                 320 


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala 
                325                 330                 335     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            340                 345                 350         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        355                 360                 365             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    370                 375                 380                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
385                 390                 395                 400 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                405                 410                 415     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            420                 425                 430         


Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    450                 455                 460                 


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
465                 470                 475                 480 


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
                485                 490                 495     


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
            500                 505                 510         


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
        515                 520                 525             


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
    530                 535                 540                 


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
545                 550                 555                 560 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                565                 570                 575     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            580                 585                 590         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        595                 600                 605             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    610                 615                 620                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
625                 630                 635                 640 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                645                 650                 655     


Lys Val Glu Pro Lys Ser Cys 
            660             


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  28

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL CD3 (H2C)

<400>  29

Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL CD3 (H2C)

<400>  30

Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL CD3 (H2C)

<400>  31

Ala Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH CD3 (H2C)

<400>  32

Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
1               5                   10  


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH CD3 (H2C)

<400>  33

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH CD3 (H2C)

<400>  34

His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  


<210>  35
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   VL CD3 (H2C)

<400>  35

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  36
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   VH CD3 (H2C)

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  37
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL CD3 (H2C)

<400>  37

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
1               5                   10                  15      


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            20                  25                  30          


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        35                  40                  45              


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
65                  70                  75                  80  


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                85                  90                  95      


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105 


<210>  38
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1 CD3 (H2C)

<400>  38

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys 
            100             


<210>  39
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIGHT CHAIN CD3 (VHCL)

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  40
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEAVY CHAIN CD3 (VLCH1)

<400>  40

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Val Glu Pro Lys Ser Cys 
    210                 


<210>  41
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAB(MCSP)-FAB(MCSP)-XFAB(CD3)

<400>  41

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
225                 230                 235                 240 


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
                245                 250                 255     


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
            260                 265                 270         


Glu Trp Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
        275                 280                 285             


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
    290                 295                 300                 


Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
305                 310                 315                 320 


Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                325                 330                 335     


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
            340                 345                 350         


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
        355                 360                 365             


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
    370                 375                 380                 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
385                 390                 395                 400 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
                405                 410                 415     


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
            420                 425                 430         


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
    450                 455                 460                 


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
465                 470                 475                 480 


Val Thr Ser Gly Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
                485                 490                 495     


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
            500                 505                 510         


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
        515                 520                 525             


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu 
    530                 535                 540                 


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
545                 550                 555                 560 


Leu Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                565                 570                 575     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            580                 585                 590         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        595                 600                 605             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    610                 615                 620                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
625                 630                 635                 640 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                645                 650                 655     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            660                 665     


<210>  42
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIGHT CHAIN CD3

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Ser Val 
        35                  40                  45              


Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Leu Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
        115                 120                 125             


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
    130                 135                 140                 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
145                 150                 155                 160 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
                165                 170                 175     


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
            180                 185                 190         


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
        195                 200                 205             


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220             


<210>  43
<211>  664
<212>  PRT
<213>  Mus musculus

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Pro Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Asn Lys Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Ser Ser Phe Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Gly Ser Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    210                 215                 220                 


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu 
225                 230                 235                 240 


Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
                245                 250                 255     


Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly 
            260                 265                 270         


Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
        275                 280                 285             


Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys 
    290                 295                 300                 


Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Asp 
305                 310                 315                 320 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser 
                325                 330                 335     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            340                 345                 350         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        355                 360                 365             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    370                 375                 380                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
385                 390                 395                 400 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                405                 410                 415     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            420                 425                 430         


Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    450                 455                 460                 


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
465                 470                 475                 480 


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
                485                 490                 495     


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
            500                 505                 510         


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
        515                 520                 525             


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
    530                 535                 540                 


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
545                 550                 555                 560 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                565                 570                 575     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            580                 585                 590         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        595                 600                 605             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    610                 615                 620                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
625                 630                 635                 640 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                645                 650                 655     


Lys Val Glu Pro Lys Ser Cys Asp 
            660                 


<210>  44
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL MCSP DNA

<400>  44
gatattgtgc tcacacagtc tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattaga aattatttaa actggtatca gcagagacca      120

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  45
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH MCSP DNA

<400>  45
gaggtgcagc tgcaggaatc tggccctggc ctggtcaagc caagccagag tctgagcctg       60

acctgcagcg tgaccggcta cagcattacc agcggctact actggaactg gattcggcag      120

ttccccggca ataagctgga atggatgggc tacatcacct acgacggcag caacaactac      180

aaccccagcc tgaagaaccg gatcagcatc acccgggaca ccagcaagaa ccagttcttc      240

ctgaagctga acagcgtgac caccgaggac accgccacat actattgcgc cgacttcgac      300

tactggggcc agggcaccac cctgaccgtg tccagc                                336


<210>  46
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CL MCSP DNA

<400>  46
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  47
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1 MCSP DNA

<400>  47
gccagcacaa agggccctag cgtgttccct ctggccccca gcagcaagag cacaagcggc       60

ggaacagccg ccctgggctg cctcgtgaag gactacttcc ccgagcccgt gacagtgtct      120

tggaacagcg gagccctgac aagcggcgtg cacaccttcc ctgccgtgct gcagagcagc      180

ggcctgtact ccctgagcag cgtggtcacc gtgcctagca gcagcctggg cacccagacc      240

tacatctgca acgtgaacca caagcccagc aacaccaaag tggacaagaa ggtggagccc      300

aagagctgtg at                                                          312


<210>  48
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGHT CHAIN MCSP DNA

<400>  48
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc       60

aggtgtgata ttgtgctcac acagtctcca tcctccctgt ctgcctctct gggagacaga      120

gtcaccatca gttgcagtgc aagtcagggc attagaaatt atttaaactg gtatcagcag      180

agaccagatg gaactgttaa actcctgatc tattacacat caagtttaca ctcaggagtc      240

ccatcaaggt tcagtggcag tgggtctggg acagattatt ctctcaccat cagcaacctg      300

gaacctgaag atattgccac ttactattgt cagcagtata gtaagcttcc ttggacgttc      360

ggtggaggca ccaagctgga aatcaaacgt acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta g               711


<210>  49
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEAVY CHAIN MCSP DNA

<400>  49
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcggag       60

gtgcagctgc aggaatctgg ccctggcctg gtcaagccaa gccagagtct gagcctgacc      120

tgcagcgtga ccggctacag cattaccagc ggctactact ggaactggat tcggcagttc      180

cccggcaata agctggaatg gatgggctac atcacctacg acggcagcaa caactacaac      240

cccagcctga agaaccggat cagcatcacc cgggacacca gcaagaacca gttcttcctg      300

aagctgaaca gcgtgaccac cgaggacacc gccacatact attgcgccga cttcgactac      360

tggggccagg gcaccaccct gaccgtgtcc agcgccagca caaagggccc tagcgtgttc      420

cctctggccc ccagcagcaa gagcacaagc ggcggaacag ccgccctggg ctgcctcgtg      480

aaggactact tccccgagcc cgtgacagtg tcttggaaca gcggagccct gacaagcggc      540

gtgcacacct tccctgccgt gctgcagagc agcggcctgt actccctgag cagcgtggtc      600

accgtgccta gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      660

agcaacacca aagtggacaa gaaggtggag cccaagagct gtgat                      705


<210>  50
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL CD3 DNA

<400>  50
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gtccagc                                          327


<210>  51
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH CD3 DNA

<400>  51
gaggtgcagc tggtcgagag cggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggcta cagcttcacc ggctacacca tgaactgggt ccggcaggca      120

cctggcaagg gactggaatg ggtggccctg atcaacccct acaagggcgt gagcacctac      180

aaccagaagt tcaaggaccg gttcaccatc agcgtggaca agagcaagaa caccgcctat      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaagcggc      300

tactacggcg acagcgactg gtacttcgac gtgtggggcc agggcaccct cgtgaccgtg      360

tctagc                                                                 366


<210>  52
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CL CD3 DNA

<400>  52
gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact       60

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag      120

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag      180

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac      240

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc      300

aacaggggag agtgttga                                                    318


<210>  53
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1 CD3 DNA

<400>  53
accaagggcc cctccgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca       60

gccgccctcg gctgcctggt caaggactac ttccccgagc ccgtgaccgt gtcctggaac      120

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      180

tacagcctgt ccagcgtggt caccgtgccc tccagcagcc tgggcaccca gacctacatc      240

tgcaacgtga accacaagcc cagcaatacc aaggtggaca agaaggtgga gcccaagagc      300

tgctga                                                                 306


<210>  54
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGHT CHAIN CD3 (VHCL) DNA

<400>  54
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgcagctgg tcgagagcgg aggcggcctg gtgcagcctg gcggcagcct gagactgagc      120

tgcgccgcca gcggctacag cttcaccggc tacaccatga actgggtccg gcaggcacct      180

ggcaagggac tggaatgggt ggccctgatc aacccctaca agggcgtgag cacctacaac      240

cagaagttca aggaccggtt caccatcagc gtggacaaga gcaagaacac cgcctatctg      300

cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgcgccag aagcggctac      360

tacggcgaca gcgactggta cttcgacgtg tggggccagg gcaccctcgt gaccgtgtct      420

agcgctagcg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa      480

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta      540

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag      600

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac      660

gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca      720

aagagcttca acaggggaga gtgttga                                          747


<210>  55
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEAVY CHAIN (VLCH1) CD3 DNA

<400>  55
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gtccagcgct agcaccaagg gcccctccgt gttccccctg      360

gcccccagca gcaagagcac cagcggcggc acagccgccc tcggctgcct ggtcaaggac      420

tacttccccg agcccgtgac cgtgtcctgg aacagcggag ccctgacctc cggcgtgcac      480

accttccccg ccgtgctgca gagcagcggc ctgtacagcc tgtccagcgt ggtcaccgtg      540

ccctccagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaat      600

accaaggtgg acaagaaggt ggagcccaag agctgctga                             639


<210>  56
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL CD3 DNA

<400>  56
cagaccgtgg tgacacagga acccagcctg accgtctccc ctggcggcac cgtgaccctg       60

acctgtggaa gcagcacagg cgccgtgacc agcggctact accccaactg ggtgcagcag      120

aagcccggcc aggcccctag aggactgatc ggcggcacca agtttctggc ccctggcacc      180

cccgccagat tctctggctc tctgctgggc ggcaaggccg ccctgacact gtctggcgtg      240

cagcctgagg acgaggccga gtactactgc gccctgtggt acagcaacag atgggtgttc      300

ggcggaggca ccaagctgac cgtgctgagc agc                                   333


<210>  57
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH CD3 DNA

<400>  57
gaggtgcagc tggtggaaag cggcggagga ctggtgcagc ctggcggaag cctgaagctg       60

tcttgcgccg ccagcggctt caccttcaac aaatacgcca tgaactgggt gcgccaggcc      120

cctggcaagg gactggaatg ggtggcccgg atcagaagca agtacaacaa ctacgccacc      180

tactacgccg acagcgtgaa ggaccggttc accatcagcc gggacgacag caagaacacc      240

gcctacctgc agatgaacaa cctgaaaacc gaggacaccg ccgtgtacta ctgcgtgcgg      300

cacggcaact tcggcaacag ctacatcagc tactgggcct actggggaca gggcaccctg      360

gtgacagtgt ccagc                                                       375


<210>  58
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL CD3 DNA

<400>  58

Gly Thr Gly Gly Cys Thr Gly Cys Ala Cys Cys Ala Thr Cys Thr Gly 
1               5                   10                  15      


Thr Cys Thr Thr Cys Ala Thr Cys Thr Thr Cys Cys Cys Gly Cys Cys 
            20                  25                  30          


Ala Thr Cys Thr Gly Ala Thr Gly Ala Gly Cys Ala Gly Thr Thr Gly 
        35                  40                  45              


Ala Ala Ala Thr Cys Thr Gly Gly Ala Ala Cys Thr Gly Cys Cys Thr 
    50                  55                  60                  


Cys Thr Gly Thr Thr Gly Thr Gly Thr Gly Cys Cys Thr Gly Cys Thr 
65                  70                  75                  80  


Gly Ala Ala Thr Ala Ala Cys Thr Thr Cys Thr Ala Thr Cys Cys Cys 
                85                  90                  95      


Ala Gly Ala Gly Ala Gly Gly Cys Cys Ala Ala Ala Gly Thr Ala Cys 
            100                 105                 110         


Ala Gly Thr Gly Gly Ala Ala Gly Gly Thr Gly Gly Ala Thr Ala Ala 
        115                 120                 125             


Cys Gly Cys Cys Cys Thr Cys Cys Ala Ala Thr Cys Gly Gly Gly Thr 
    130                 135                 140                 


Ala Ala Cys Thr Cys Cys Cys Ala Gly Gly Ala Gly Ala Gly Thr Gly 
145                 150                 155                 160 


Thr Cys Ala Cys Ala Gly Ala Gly Cys Ala Gly Gly Ala Cys Ala Gly 
                165                 170                 175     


Cys Ala Ala Gly Gly Ala Cys Ala Gly Cys Ala Cys Cys Thr Ala Cys 
            180                 185                 190         


Ala Gly Cys Cys Thr Cys Ala Gly Cys Ala Gly Cys Ala Cys Cys Cys 
        195                 200                 205             


Thr Gly Ala Cys Gly Cys Thr Gly Ala Gly Cys Ala Ala Ala Gly Cys 
    210                 215                 220                 


Ala Gly Ala Cys Thr Ala Cys Gly Ala Gly Ala Ala Ala Cys Ala Cys 
225                 230                 235                 240 


Ala Ala Ala Gly Thr Cys Thr Ala Cys Gly Cys Cys Thr Gly Cys Gly 
                245                 250                 255     


Ala Ala Gly Thr Cys Ala Cys Cys Cys Ala Thr Cys Ala Gly Gly Gly 
            260                 265                 270         


Cys Cys Thr Gly Ala Gly Cys Thr Cys Gly Cys Cys Cys Gly Thr Cys 
        275                 280                 285             


Ala Cys Ala Ala Ala Gly Ala Gly Cys Thr Thr Cys Ala Ala Cys Ala 
    290                 295                 300                 


Gly Gly Gly Gly Ala Gly Ala Gly Thr Gly Thr Thr Gly Ala 
305                 310                 315             


<210>  59
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1 CD3 DNA

<400>  59
accaagggcc cctccgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca       60

gccgccctcg gctgcctggt caaggactac ttccccgagc ccgtgaccgt gtcctggaac      120

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      180

tacagcctgt ccagcgtggt caccgtgccc tccagcagcc tgggcaccca gacctacatc      240

tgcaacgtga accacaagcc cagcaatacc aaggtggaca agaaggtgga gcccaagagc      300

tgctga                                                                 306


<210>  60
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGHT CHAIN CD3 (VHCL) DNA

<400>  60
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgcagctgg tggaaagcgg cggaggactg gtgcagcctg gcggaagcct gaagctgtct      120

tgcgccgcca gcggcttcac cttcaacaaa tacgccatga actgggtgcg ccaggcccct      180

ggcaagggac tggaatgggt ggcccggatc agaagcaagt acaacaacta cgccacctac      240

tacgccgaca gcgtgaagga ccggttcacc atcagccggg acgacagcaa gaacaccgcc      300

tacctgcaga tgaacaacct gaaaaccgag gacaccgccg tgtactactg cgtgcggcac      360

ggcaacttcg gcaacagcta catcagctac tgggcctact ggggacaggg caccctggtg      420

acagtgtcca gcgctagcgt ggctgcacca tctgtcttca tcttcccgcc atctgatgag      480

cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag      540

gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc      600

acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa      660

gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg      720

cccgtcacaa agagcttcaa caggggagag tgttga                                756


<210>  61
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEAVY CHAIN CD3 (VLCH1) DNA

<400>  61
cagaccgtgg tgacacagga acccagcctg accgtctccc ctggcggcac cgtgaccctg       60

acctgtggaa gcagcacagg cgccgtgacc agcggctact accccaactg ggtgcagcag      120

aagcccggcc aggcccctag aggactgatc ggcggcacca agtttctggc ccctggcacc      180

cccgccagat tctctggctc tctgctgggc ggcaaggccg ccctgacact gtctggcgtg      240

cagcctgagg acgaggccga gtactactgc gccctgtggt acagcaacag atgggtgttc      300

ggcggaggca ccaagctgac cgtgctgagc agcgctagca ccaagggccc ctccgtgttc      360

cccctggccc ccagcagcaa gagcaccagc ggcggcacag ccgccctcgg ctgcctggtc      420

aaggactact tccccgagcc cgtgaccgtg tcctggaaca gcggagccct gacctccggc      480

gtgcacacct tccccgccgt gctgcagagc agcggcctgt acagcctgtc cagcgtggtc      540

accgtgccct ccagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      600

agcaatacca aggtggacaa gaaggtggag cccaagagct gctga                      645


<210>  62
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAB(MCSP)-XFAB (CD3) DNA

<400>  62
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcggag       60

gtgcagctgc aggaaagcgg ccctggcctg gtgaaaccca gccagagcct gagcctgacc      120

tgcagcgtga ccggctacag catcaccagc ggctactact ggaactggat cagacagttc      180

cccggcaaca agctggaatg gatgggctac atcacctacg acggcagcaa caactacaac      240

cccagcctga agaacagaat cagcatcacc cgggacacca gcaagaacca gttcttcctg      300

aagctgaaca gcgtgaccac cgaggacacc gccacctact actgcgccga cttcgactac      360

tggggccagg gcaccaccct gaccgtgtcc tccgctagca ccaagggacc cagcgtgttc      420

cccctggcac ccagcagcaa gagcacatct ggcggaacag ccgctctggg ctgtctggtg      480

aaagactact tccccgagcc cgtgaccgtg tcttggaact ctggcgccct gaccagcggc      540

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actccctgag cagcgtggtg      600

acagtgccca gcagcagcct gggaacccag acctacatct gcaacgtgaa ccacaagccc      660

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgatggcgg aggaggctcc      720

ggaggcggag gctctgatat ccagatgacc cagagcccca gctctctgag cgccagcgtg      780

ggcgacagag tgaccatcac ctgtcgggcc agccaggaca tcagaaacta cctgaactgg      840

tatcagcaga agcccggcaa ggcccccaag ctgctgatct actacaccag cagactggaa      900

agcggcgtgc cctccagatt ttccggcagc ggctccggca ccgactacac cctgaccatc      960

agcagcctgc agcccgagga tttcgccaca tattactgcc agcagggcaa taccctgccc     1020

tggaccttcg gacagggcac aaaagtggaa atcaag                               1056


<210>  63
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAB(MCSP)-FAB(MCSP)-XFAB (CD3) DNA

<400>  63
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcggag       60

gtgcagctgc aggaatctgg ccctggcctg gtcaagccaa gccagagtct gagcctgacc      120

tgcagcgtga ccggctacag cattaccagc ggctactact ggaactggat tcggcagttc      180

cccggcaata agctggaatg gatgggctac atcacctacg acggcagcaa caactacaac      240

cccagcctga agaaccggat cagcatcacc cgggacacca gcaagaacca gttcttcctg      300

aagctgaaca gcgtgaccac cgaggacacc gccacatact attgcgccga cttcgactac      360

tggggccagg gcaccaccct gaccgtgtcc agcgccagca caaagggccc tagcgtgttc      420

cctctggccc ccagcagcaa gagcacaagc ggcggaacag ccgccctggg ctgcctcgtg      480

aaggactact tccccgagcc cgtgacagtg tcttggaaca gcggagccct gacaagcggc      540

gtgcacacct tccctgccgt gctgcagagc agcggcctgt actccctgag cagcgtggtc      600

accgtgccta gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      660

agcaacacca aagtggacaa gaaggtggag cccaagagct gtgatggcgg aggagggtcc      720

ggaggcggtg gctccgaggt gcagctgcag gaatctggcc ctggcctggt caagccaagc      780

cagagtctga gcctgacctg cagcgtgacc ggctacagca ttaccagcgg ctactactgg      840

aactggattc ggcagttccc cggcaataag ctggaatgga tgggctacat cacctacgac      900

ggcagcaaca actacaaccc cagcctgaag aaccggatca gcatcacccg ggacaccagc      960

aagaaccagt tcttcctgaa gctgaacagc gtgaccaccg aggacaccgc cacatactat     1020

tgcgccgact tcgactactg gggccagggc accaccctga ccgtgtccag cgccagcaca     1080

aagggcccta gcgtgttccc tctggccccc agcagcaaga gcacaagcgg cggaacagcc     1140

gccctgggct gcctcgtgaa ggactacttc cccgagcccg tgacagtgtc ttggaacagc     1200

ggagccctga caagcggcgt gcacaccttc cctgccgtgc tgcagagcag cggcctgtac     1260

tccctgagca gcgtggtcac cgtgcctagc agcagcctgg gcacccagac ctacatctgc     1320

aacgtgaacc acaagcccag caacaccaaa gtggacaaga aggtggagcc caagagctgt     1380

gatggcggag gagggtccgg cggcggtgga tccgacatcc agatgaccca gagcccctct     1440

agcctgagcg ccagcgtggg cgacagagtg accatcacct gtcgggccag ccaggacatc     1500

agaaactacc tgaactggta tcagcagaag cccggcaagg cccccaagct gctgatctac     1560

tacacctcta gactggaaag cggcgtgccc agccggttta gcggcagcgg ctccggcacc     1620

gactacaccc tgaccatcag cagcctgcag cccgaggact tcgccaccta ctactgccag     1680

cagggcaaca cactcccctg gaccttcggc cagggcacca aggtggagat caagtccagc     1740

gctagcacca agggcccctc cgtgttcccc ctggccccca gcagcaagag caccagcggc     1800

ggcacagccg ccctcggctg cctggtcaag gactacttcc ccgagcccgt gaccgtgtcc     1860

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagcagc     1920

ggcctgtaca gcctgtccag cgtggtcacc gtgccctcca gcagcctggg cacccagacc     1980

tacatctgca acgtgaacca caagcccagc aataccaagg tggacaagaa ggtggagccc     2040

aagagctgct ga                                                         2052


<210>  64
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAB(MCSP)-XFAB (CD3)-FAB(MCSP)

<400>  64
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcggag       60

gtgcagctgc aggaaagcgg ccctggcctg gtgaaaccca gccagagcct gagcctgacc      120

tgcagcgtga ccggctacag catcaccagc ggctactact ggaactggat cagacagttc      180

cccggcaaca agctggaatg gatgggctac atcacctacg acggcagcaa caactacaac      240

cccagcctga agaacagaat cagcatcacc cgggacacca gcaagaacca gttcttcctg      300

aagctgaaca gcgtgaccac cgaggacacc gccacctact actgcgccga cttcgactac      360

tggggccagg gcaccaccct gaccgtgtcc tccgctagca ccaagggacc cagcgtgttc      420

cccctggcac ccagcagcaa gagcacatct ggcggaacag ccgctctggg ctgtctggtg      480

aaagactact tccccgagcc cgtgaccgtg tcttggaact ctggcgccct gaccagcggc      540

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actccctgag cagcgtggtg      600

acagtgccca gcagcagcct gggaacccag acctacatct gcaacgtgaa ccacaagccc      660

agcaacacca aggtggacaa gaaggtggaa cccaagagct gcgatggcgg aggaggctcc      720

ggaggcggag gctctgatat ccagatgacc cagagcccca gctctctgag cgccagcgtg      780

ggcgacagag tgaccatcac ctgtcgggcc agccaggaca tcagaaacta cctgaactgg      840

tatcagcaga agcccggcaa ggcccccaag ctgctgatct actacaccag cagactggaa      900

agcggcgtgc cctccagatt ttccggcagc ggctccggca ccgactacac cctgaccatc      960

agcagcctgc agcccgagga tttcgccaca tattactgcc agcagggcaa taccctgccc     1020

tggaccttcg gacagggcac aaaagtggaa atcaagagca gcgcttccac caaaggccct     1080

tccgtgtttc ctctggctcc tagctccaag tccacctctg gaggcaccgc tgctctcgga     1140

tgcctcgtga aggattattt tcctgagcct gtgacagtgt cctggaatag cggagcactg     1200

acctctggag tgcatacttt ccccgctgtg ctgcagtcct ctggactgta cagcctgagc     1260

agcgtggtga cagtgcccag cagcagcctg ggcacccaga cctacatctg caacgtgaac     1320

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagtcttg tggcggaggc     1380

ggatccggcg gagggggatc tgaggtgcag ctgcaggaaa gcggccctgg cctggtgaaa     1440

cccagccaga gcctgagcct gacctgcagc gtgaccggct acagcatcac cagcggctac     1500

tactggaact ggatcagaca gttccccggc aacaagctgg aatggatggg ctacatcacc     1560

tacgacggca gcaacaacta caaccccagc ctgaagaaca gaatcagcat cacccgggac     1620

accagcaaga accagttctt cctgaagctg aacagcgtga ccaccgagga caccgccacc     1680

tactactgcg ccgacttcga ctactggggc cagggcacca ccctgaccgt gtcctccgcc     1740

tctaccaagg gccccagcgt gttccccctg gcacccagca gcaagagcac atctggcgga     1800

acagccgctc tgggctgtct ggtgaaagac tacttccccg agcccgtgac cgtgtcttgg     1860

aactctggcg ccctgaccag cggcgtgcac acctttccag ccgtgctgca gagcagcggc     1920

ctgtactccc tgtcctccgt ggtcaccgtg ccctctagct ccctgggaac acagacatat     1980

atctgtaatg tcaatcacaa gccttccaac accaaagtcg ataagaaagt cgagcccaag     2040

agctgctga                                                             2049


<210>  65
<211>  2058
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FAB (MCSP)-FAB(MCSP)-XFAB (CD3) DNA

<400>  65
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcggag       60

gtgcagctgc aggaatctgg ccctggcctg gtcaagccaa gccagagtct gagcctgacc      120

tgcagcgtga ccggctacag cattaccagc ggctactact ggaactggat tcggcagttc      180

cccggcaata agctggaatg gatgggctac atcacctacg acggcagcaa caactacaac      240

cccagcctga agaaccggat cagcatcacc cgggacacca gcaagaacca gttcttcctg      300

aagctgaaca gcgtgaccac cgaggacacc gccacatact attgcgccga cttcgactac      360

tggggccagg gcaccaccct gaccgtgtcc agcgccagca caaagggccc tagcgtgttc      420

cctctggccc ccagcagcaa gagcacaagc ggcggaacag ccgccctggg ctgcctcgtg      480

aaggactact tccccgagcc cgtgacagtg tcttggaaca gcggagccct gacaagcggc      540

gtgcacacct tccctgccgt gctgcagagc agcggcctgt actccctgag cagcgtggtc      600

accgtgccta gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      660

agcaacacca aagtggacaa gaaggtggag cccaagagct gtgatggcgg aggagggtcc      720

ggaggcggtg gctccgaggt gcagctgcag gaatctggcc ctggcctggt caagccaagc      780

cagagtctga gcctgacctg cagcgtgacc ggctacagca ttaccagcgg ctactactgg      840

aactggattc ggcagttccc cggcaataag ctggaatgga tgggctacat cacctacgac      900

ggcagcaaca actacaaccc cagcctgaag aaccggatca gcatcacccg ggacaccagc      960

aagaaccagt tcttcctgaa gctgaacagc gtgaccaccg aggacaccgc cacatactat     1020

tgcgccgact tcgactactg gggccagggc accaccctga ccgtgtccag cgccagcaca     1080

aagggcccta gcgtgttccc tctggccccc agcagcaaga gcacaagcgg cggaacagcc     1140

gccctgggct gcctcgtgaa ggactacttc cccgagcccg tgacagtgtc ttggaacagc     1200

ggagccctga caagcggcgt gcacaccttc cctgccgtgc tgcagagcag cggcctgtac     1260

tccctgagca gcgtggtcac cgtgcctagc agcagcctgg gcacccagac ctacatctgc     1320

aacgtgaacc acaagcccag caacaccaaa gtggacaaga aggtggagcc caagagctgt     1380

gatggcggag gagggtccgg cggcggtgga tcccagaccg tggtgacaca ggaacccagc     1440

ctgaccgtct cccctggcgg caccgtgacc ctgacctgtg gaagcagcac aggcgccgtg     1500

accagcggct actaccccaa ctgggtgcag cagaagcccg gccaggcccc tagaggactg     1560

atcggcggca ccaagtttct ggcccctggc acccccgcca gattctctgg ctctctgctg     1620

ggcggcaagg ccgccctgac actgtctggc gtgcagcctg aggacgaggc cgagtactac     1680

tgcgccctgt ggtacagcaa cagatgggtg ttcggcggag gcaccaagct gaccgtgctg     1740

agcagcgcta gcaccaaggg cccctccgtg ttccccctgg cccccagcag caagagcacc     1800

agcggcggca cagccgccct cggctgcctg gtcaaggact acttccccga gcccgtgacc     1860

gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag     1920

agcagcggcc tgtacagcct gtccagcgtg gtcaccgtgc cctccagcag cctgggcacc     1980

cagacctaca tctgcaacgt gaaccacaag cccagcaata ccaaggtgga caagaaggtg     2040

gagcccaaga gctgctga                                                   2058


<210>  66
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGHT CHAIN CD3 (VHCL) DNA

<400>  66
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgcagctgg tggaaagcgg cggaggcctg gtgcagcccg gcaagagcct gaagctgagc      120

tgcgaggcca gcggcttcac cttcagcggc tacggcatgc actgggtgag acaggcccct      180

ggcagaggac tggaaagcgt ggcctacatc accagcagca gcatcaacat taagtacgcc      240

gacgccgtga agggccggtt caccgtgtcc agggataacg ccaagaacct gctgttcctg      300

cagatgaaca tcctgaagtc cgaggacacc gctatgtatt actgcgccag attcgactgg      360

gacaagaact actggggcca gggcaccatg gtcacagtgt ctagcgctag cgtggctgca      420

ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt      480

gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac      540

gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc      600

tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac      660

gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga      720

gagtgttga                                                              729


<210>  67
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XFAB (CD3)-FAB(MCSP)-FAB(MCSP) DNA

<400>  67
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgac       60

atccagatga cccagagccc cagcagcctg cctgccagcc tgggcgacag agtgaccatc      120

aactgccagg ccagccagga catcagcaac tacctgaact ggtatcagca gaagcctggc      180

aaggccccca agctgctgat ctactacacc aacaagctgg ccgacggcgt gcccagcaga      240

ttcagcggca gcggctccgg cagagacagc agcttcacca tctccagcct ggaaagcgag      300

gacatcggca gctactactg ccagcagtac tacaactacc cctggacctt cggccctggc      360

accaagctgg aaatcaagag cagcgcttcc accaaaggcc cttccgtgtt tcctctggct      420

cctagctcca agtccacctc tggaggcacc gctgctctcg gatgcctcgt gaaggattat      480

tttcctgagc ctgtgacagt gtcctggaat agcggagcac tgacctctgg agtgcatact      540

ttccccgctg tgctgcagtc ctctggactg tacagcctga gcagcgtggt gacagtgccc      600

agcagcagcc tgggcaccca gacctacatc tgcaacgtga accacaagcc cagcaacacc      660

aaggtggaca agaaggtgga acccaagtct tgtggcggag gcggatccgg cggaggaggg      720

tccgaggtgc agctgcagga atctggccct ggcctggtca agccaagcca gagtctgagc      780

ctgacctgca gcgtgaccgg ctacagcatt accagcggct actactggaa ctggattcgg      840

cagttccccg gcaataagct ggaatggatg ggctacatca cctacgacgg cagcaacaac      900

tacaacccca gcctgaagaa ccggatcagc atcacccggg acaccagcaa gaaccagttc      960

ttcctgaagc tgaacagcgt gaccaccgag gacaccgcca catactattg cgccgacttc     1020

gactactggg gccagggcac caccctgacc gtgtccagcg ccagcacaaa gggccctagc     1080

gtgttccctc tggcccccag cagcaagagc acaagcggcg gaacagccgc cctgggctgc     1140

ctcgtgaagg actacttccc cgagcccgtg acagtgtctt ggaacagcgg agccctgaca     1200

agcggcgtgc acaccttccc tgccgtgctg cagagcagcg gcctgtactc cctgagcagc     1260

gtggtcaccg tgcctagcag cagcctgggc acccagacct acatctgcaa cgtgaaccac     1320

aagcccagca acaccaaagt ggacaagaag gtggagccca agagctgtga tggcggagga     1380

gggtccggag gcggtggctc cgaggtgcag ctgcaggaat ctggccctgg cctggtcaag     1440

ccaagccaga gtctgagcct gacctgcagc gtgaccggct acagcattac cagcggctac     1500

tactggaact ggattcggca gttccccggc aataagctgg aatggatggg ctacatcacc     1560

tacgacggca gcaacaacta caaccccagc ctgaagaacc ggatcagcat cacccgggac     1620

accagcaaga accagttctt cctgaagctg aacagcgtga ccaccgagga caccgccaca     1680

tactattgcg ccgacttcga ctactggggc cagggcacca ccctgaccgt gtccagcgcc     1740

agcacaaagg gccctagcgt gttccctctg gcccccagca gcaagagcac aagcggcgga     1800

acagccgccc tgggctgcct cgtgaaggac tacttccccg agcccgtgac agtgtcttgg     1860

aacagcggag ccctgacaag cggcgtgcac accttccctg ccgtgctgca gagcagcggc     1920

ctgtactccc tgagcagcgt ggtcaccgtg cctagcagca gcctgggcac ccagacctac     1980

atctgcaacg tgaaccacaa gcccagcaac accaaagtgg acaagaaggt ggagcccaag     2040

agctgtgatt ga                                                         2052


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR1

<400>  68

Asp Tyr Lys Ile His 
1               5   


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR2

<400>  69

Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR3

<400>  70

Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala 
1               5                   10      


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR1

<400>  71

Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR2

<400>  72

Asn Thr Asn Asn Leu Gln Thr 
1               5           


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR3

<400>  73

Leu Gln His Asn Ser Phe Pro Thr 
1               5               


<210>  74
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 VH

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Lys Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  75
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 VL

<400>  75

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR1

<400>  76

Ser Tyr Ala Met Ser 
1               5   


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR2

<400>  77

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR3

<400>  78

Tyr Cys Ala Lys Gly Trp Phe Gly 
1               5               


<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR1

<400>  79

Arg Ala Ser Gln Ser Val Thr Ser Ser Tyr Leu 
1               5                   10      


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR2

<400>  80

Asn Val Gly Ser Arg Arg Ala 
1               5           


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR3

<400>  81

Cys Gln Gln Gly Ile Met Leu Pro Pro 
1               5                   


<210>  82
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 VH

<400>  82

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  83
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 VL

<400>  83

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR1

<400>  84

Glu Phe Gly Met Asn 
1               5   


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR2

<400>  85

Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR3

<400>  86

Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  87
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR1

<400>  87

Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala 
1               5                   10      


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR2

<400>  88

Ser Ala Ser Tyr Arg Lys Arg 
1               5           


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR3

<400>  89

His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr 
1               5                   10  


<210>  90
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A VH

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  91
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A VL

<400>  91

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR1

<400>  92

Gly Tyr Thr Ile Thr Asp Ser Asn Ile His 
1               5                   10  


<210>  93
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR2

<400>  93

Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln 
1               5                   10              


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR3

<400>  94

Gly Asn Pro Trp Leu Ala Tyr 
1               5           


<210>  95
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR1

<400>  95

Arg Ala Ser Glu Ser Leu Asp Asn Tyr Gly Ile Arg Phe Leu Thr 
1               5                   10                  15  


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR2

<400>  96

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR3

<400>  97

Gln Gln Thr Lys Glu Val Pro Trp Ser 
1               5                   


<210>  98
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VH

<400>  98

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  99
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VL

<400>  99

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105                 110     


<210>  100
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain antiCD33

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  101
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain V9 (VH-CL)

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys 
225                 


<210>  102
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 Fab-Crossfab (VH-CH1-VL-CH1)

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
225                 230                 235                 240 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                245                 250                 255     


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
            260                 265                 270         


Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val 
        275                 280                 285             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
    290                 295                 300                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
305                 310                 315                 320 


Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
                325                 330                 335     


Lys Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
            340                 345                 350         


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
        355                 360                 365             


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
    370                 375                 380                 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
385                 390                 395     


<210>  103
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  103

Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      


Val Cys Glu Asn Cys Met Glu Met Asp 
            100                 105 


<210>  104
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain antiCD33 DNA

<400>  104
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgac       60

atccagatga cccagagccc cagcagcctg agcgccagcg tgggcgacag agtgaccatc      120

acctgtcggg ccagcgagag cgtggacaac tacggcatca gcttcatgaa ctggttccag      180

cagaagcccg gcaaggcccc caagctgctg atctacgccg ccagcaatca gggcagcggc      240

gtgcccagca gattcagcgg ctctggcagc ggcaccgact tcaccctgac catcagcagc      300

ctgcagcccg acgacttcgc cacctactac tgccagcaga gcaaagaggt gccctggacc      360

ttcggccagg gcaccaaggt ggaaatcaag cgtacggtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttag            714


<210>  105
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain V9 (VH-CL) DNA

<400>  105
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgcagctgg tcgagagcgg aggcggcctg gtgcagcctg gcggcagcct gagactgagc      120

tgcgccgcca gcggctacag cttcaccggc tacaccatga actgggtccg gcaggcacct      180

ggcaagggac tggaatgggt ggccctgatc aacccctaca agggcgtgag cacctacaac      240

cagaagttca aggaccggtt caccatcagc gtggacaaga gcaagaacac cgcctatctg      300

cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgcgccag aagcggctac      360

tacggcgaca gcgactggta cttcgacgtg tggggccagg gcaccctcgt gaccgtgtct      420

agcgctagcg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa      480

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta      540

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag      600

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac      660

gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca      720

aagagcttca acaggggaga gtgttga                                          747


<210>  106
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 Fab-Crossfab (VH-CH1-VL-CH1) DNA

<400>  106
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcccag       60

gtgcagctgg tgcagtctgg cgccgaagtg aagaaacccg gcagcagcgt gaaggtgtcc      120

tgcaaggcca gcggctacac cttcaccgac tacaacatgc actgggtccg ccaggcccca      180

ggccagggac tggaatggat cggctacatc tacccctaca acggcggcac cggctacaac      240

cagaagttca agagcaaggc caccatcacc gccgacgaga gcaccaacac cgcctacatg      300

gaactgagca gcctgcggag cgaggacacc gccgtgtact actgcgccag aggcagaccc      360

gccatggact actggggcca gggcaccctg gtgacagtgt ccagcgccag cacaaagggc      420

cctagcgtgt tccctctggc ccccagcagc aagagcacaa gcggcggaac agccgccctg      480

ggctgcctcg tgaaggacta cttccccgag cccgtgacag tgtcttggaa cagcggagcc      540

ctgacaagcg gcgtgcacac cttccctgcc gtgctgcaga gcagcggcct gtactccctg      600

agcagcgtgg tcaccgtgcc tagcagcagc ctgggcaccc agacctacat ctgcaacgtg      660

aaccacaagc ccagcaacac caaagtggac aagaaggtgg agcccaagag ctgtgatggc      720

ggaggagggt ccggaggcgg tggatccgac atccagatga cccagagccc ctctagcctg      780

agcgccagcg tgggcgacag agtgaccatc acctgtcggg ccagccagga catcagaaac      840

tacctgaact ggtatcagca gaagcccggc aaggccccca agctgctgat ctactacacc      900

tctagactgg aaagcggcgt gcccagccgg tttagcggca gcggctccgg caccgactac      960

accctgacca tcagcagcct gcagcccgag gacttcgcca cctactactg ccagcagggc     1020

aacacactcc cctggacctt cggccagggc accaaggtgg agatcaagtc cagcgctagc     1080

accaagggcc cctccgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca     1140

gccgccctcg gctgcctggt caaggactac ttccccgagc ccgtgaccgt gtcctggaac     1200

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg     1260

tacagcctgt ccagcgtggt caccgtgccc tccagcagcc tgggcaccca gacctacatc     1320

tgcaacgtga accacaagcc cagcaatacc aaggtggaca agaaggtgga gcccaagagc     1380

tgctga                                                                1386


<210>  107
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCSP CDR1 VH DNA

<400>  107
ggctactcca tcaccagtgg ttattactgg aac                                    33


<210>  108
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCSP CDR2 VH

<400>  108
tacataacct acgacggtag caataactac aacccatctc tcaaaaat                    48


<210>  109
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCSP CDR3 VH

<400>  109
tttgactac                                                                9


<210>  110
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCSP CDR1 VL DNA

<400>  110
agtgcaagtc agggcattag aaattattta aac                                    33


<210>  111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCSP CDR2 VL

<400>  111
tacacatcaa gtttacactc a                                                 21


<210>  112
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCSP CDR3 VL

<400>  112
cagcagtata gtaagcttcc ttggacg                                           27


<210>  113
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 CDR1 VH

<400>  113
gactacaaga tacac                                                        15


<210>  114
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 CDR2  VH

<400>  114
tatttcaacc ctaacagcgg ttatagtacc tacgcacaga agttccaggg c                51


<210>  115
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 CDR3 VH

<400>  115
ctatccccag gcggttacta tgttatggat gcc                                    33


<210>  116
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 CDR1 VL

<400>  116
cgggcaagtc agggcattaa caattactta aat                                    33


<210>  117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 CDR2 VL

<400>  117
aataccaaca acttgcagac a                                                 21


<210>  118
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 CDR3 VL

<400>  118
ttgcagcata atagttttcc cacg                                              24


<210>  119
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 VH

<400>  119
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggttt cacattcact gactacaaga tacactgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggatat ttcaacccta acagcggtta tagtacctac      180

gcacagaagt tccagggcag ggtcaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagactatcc      300

ccaggcggtt actatgttat ggatgcctgg ggccaaggga ccaccgtgac cgtctcctca      360


<210>  120
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 VL

<400>  120
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaac aattacttaa attggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctataat accaacaact tgcagacagg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gaagattttg ccacctatta ctgcttgcag cataatagtt ttcccacgtt tggccagggc      300

accaagctcg agatcaag                                                    318


<210>  121
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 CDR1 VH

<400>  121
agctacgcca tgagc                                                        15


<210>  122
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 CDR2 VH

<400>  122
gccatctccg gcagcggagg cagcacctac tacgccgaca gcgtgaag                    48


<210>  123
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 CDR3 VH

<400>  123
tattgcgcca agggatggtt cggc                                              24


<210>  124
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 CDR1 VL

<400>  124
agagccagcc agagcgtgac cagcagctac ctg                                    33


<210>  125
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 CDR2 VL

<400>  125
aacgtgggca gcagacgggc c                                                 21


<210>  126
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 CDR3 VL

<400>  126
tgccagcagg gcatcatgct gcccccc                                           27


<210>  127
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 VH

<400>  127
gaggtgcagc tgctggaatc tggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaagg gactggaatg ggtgtccgcc atctccggca gcggaggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agcagagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgccgtgt attattgcgc caagggatgg      300

ttcggcggct tcaactactg gggccaggga accctggtga cagtgtccag c               351


<210>  128
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 VL

<400>  128
gagatcgtgc tgacccagtc tcccggcacc ctgagcctga gccctggcga gagagccacc       60

ctgagctgca gagccagcca gagcgtgacc agcagctacc tggcctggta tcagcagaag      120

cccggccagg cccccagact gctgatcaac gtgggcagca gacgggccac cggcatcccc      180

gatagattca gcggcagcgg ctccggcacc gacttcaccc tgaccatcag ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagggcatca tgctgccccc caccttcggc      300

cagggcacca aggtggaaat caag                                             324


<210>  129
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A CDR1 VH

<400>  129
gagttcggca tgaac                                                        15


<210>  130
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A CDR2 VH

<400>  130
tggatcaaca ccaagaccgg cgaggccacc tacgtggaag agttcaaggg c                51


<210>  131
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A CDR3 VH

<400>  131
tgggacttcg cctattacgt ggaagccatg gactac                                 36


<210>  132
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A CDR1 VL

<400>  132
aaggccagtg cggctgtggg tacgtatgtt gcg                                    33


<210>  133
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A CDR2 VL

<400>  133
tcggcatcct accgcaaaag g                                                 21


<210>  134
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A CDR3 VL

<400>  134
caccaatatt acacctatcc tctattcacg                                        30


<210>  135
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A VH

<400>  135
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  136
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A VL

<400>  136
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caag                                             324


<210>  137
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 CDR1 VH

<400>  137
ggctacacca tcaccgacag caacatccac                                        30


<210>  138
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 CDR2 VH

<400>  138
tacatctacc cctacaacgg cggcaccgac tacaaccag                              39


<210>  139
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 CDR3 VH

<400>  139
ggcaacccct ggctggccta t                                                 21


<210>  140
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 CDR1 VL

<400>  140
cgggccagcg agagcctgga caactacggc atccggtttc tgacc                       45


<210>  141
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 CDR2 VL

<400>  141
gccgccagca accagggcag c                                                 21


<210>  142
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 CDR3 VL

<400>  142
cagcagacca aagaggtgcc ctggtcc                                           27


<210>  143
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VH

<400>  143
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggcagcag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccatcacc gacagcaaca tccactgggt ccgacaggcc      120

cctgggcaga gcctggaatg gatcggctac atctacccct acaacggcgg caccgactac      180

aaccagaagt tcaagaaccg ggccaccctg accgtggaca accccaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccttct actactgcgt gaacggcaac      300

ccctggctgg cctattgggg ccagggaacc ctggtcaccg tgtctagc                   348


<210>  144
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VL

<400>  144
gacatccagc tgacccagag ccccagcacc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcga gagcctggac aactacggca tccggtttct gacctggttc      120

cagcagaagc ccggcaaggc ccccaagctg ctgatgtacg ccgccagcaa ccagggcagc      180

ggcgtgccaa gcagattcag cggcagcggc tccggcaccg agttcaccct gaccatcagc      240

agcctgcagc ccgacgactt cgccacctac tactgccagc agaccaaaga ggtgccctgg      300

tccttcggcc agggcaccaa ggtggaagtg aag                                   333


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 2

<400>  145

Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  146
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3

<400>  146

Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  147
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 4

<400>  147

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


<210>  148
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 5

<400>  148

Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Ser Gly 
        


<210>  149
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (scFV)2 CD3-MCSP

<400>  149

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile 
145                 150                 155                 160 


Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr 
                165                 170                 175     


Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile 
            180                 185                 190         


Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys Leu Asn Ser Val 
        195                 200                 205             


Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Asp Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Glu 
225                 230                 235                 240 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                245                 250                 255     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
            260                 265                 270         


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        275                 280                 285             


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
    290                 295                 300                 


Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu 
305                 310                 315                 320 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                325                 330                 335     


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            340                 345                 350         


Gln Gly Thr Leu Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Met Thr 
    370                 375                 380                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
385                 390                 395                 400 


Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 
                405                 410                 415     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
            420                 425                 430         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        435                 440                 445             


Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    450                 455                 460                 


Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly 
465                 470                 475                 480 


Thr Lys Val Glu Ile Lys His His His His His His 
                485                 490         


<210>  150
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (scFv)2 MCSP-CD3 DNA

<400>  150
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggtgt gcattccgac       60

atcgtgctga cccagagccc cagcagcctg agcgccagcc tgggcgacag agtgaccatc      120

agctgcagcg cctcccaggg catcagaaac tacctgaact ggtatcagca gcggcccgac      180

ggcaccgtga agctgctgat ctactacacc agctccctgc acagcggcgt gcccagcaga      240

ttttcaggca gcggcagcgg cactgactac agcctgacca tctccaacct ggaacccgag      300

gacattgcca cctactactg ccagcagtac agcaagctgc cctggacctt cggcggaggc      360

accaagctgg aaatcaaggg cggaggcgga tccggcggag gtggaagtgg cggcggaggc      420

tctgaggtgc aattgcagga aagcggccct ggcctggtga aacccagcca gagcctgagc      480

ctgacctgca gcgtgaccgg ctactccatc accagcggct actactggaa ctggatcaga      540

cagttccccg gaaacaagct ggaatggatg ggctacatca cctacgacgg cagcaacaac      600

tacaacccca gcctgaagaa ccggatcagc atcacccggg acaccagcaa gaaccagttc      660

ttcctgaagc tgaacagcgt gaccaccgag gataccgcca cctattactg tgccgacttc      720

gactactggg gccagggcac caccctgacc gtgtcatccg gtggcggcgg atccgaagtg      780

cagctggtgg agtctggcgg tggactggtg cagccaggcg gctccctgag actgagctgc      840

gccgcctccg gctacagctt caccggctac accatgaatt gggtccgcca ggcccctgga      900

aagggactgg aatgggtggc cctgatcaac ccctacaagg gcgtgagcac ctacaaccag      960

aagttcaagg accggttcac catcagcgtg gacaagagca agaacacagc ctacctgcag     1020

atgaactccc tgagagccga ggataccgcc gtgtattact gtgcccgcag cggctactac     1080

ggcgactccg actggtactt cgacgtgtgg gggcagggaa ccctggtcac cgtgtccagc     1140

gtggaaggcg gcagcggagg atctggcggc tctggcggaa gcggcggagt ggacgatatc     1200

cagatgacac agtcccccag ctccctgagc gccagcgtgg gcgacagagt gaccatcacc     1260

tgtcgggcca gccaggacat ccggaattat ctcaattggt atcagcagaa acctggcaaa     1320

gctcctaaac tgctgatcta ctacacctcc cggctggaaa gcggcgtgcc cagcagattt     1380

tccggcagcg ggagcggcac cgattacaca ctgaccatca gcagcctgca gcccgaggac     1440

tttgccacct actattgcca gcagggcaac accctgccct ggacctttgg gcagggcaca     1500

aaggtggaga tcaagcacca ccaccatcac cactga                               1536


<210>  151
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain VL CD33 (Myelotarg)

<400>  151

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  152
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain V9 (VL-CH1)

<400>  152

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys 
    210         


<210>  153
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab-Crossfab (VH-CH1(CD33 Myelotarg) -VH-CL [V9])

<400>  153

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
225                 230                 235                 240 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                245                 250                 255     


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly 
            260                 265                 270         


Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser 
        275                 280                 285             


Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys 
    290                 295                 300                 


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
305                 310                 315                 320 


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp 
                325                 330                 335     


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            340                 345                 350         


Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        355                 360                 365             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    370                 375                 380                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
385                 390                 395                 400 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                405                 410                 415     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            420                 425                 430         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        435                 440                 445             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    450                 455                 


<210>  154
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain VL(Myelotarg) DNA

<400>  154
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgac       60

atccagctga cccagagccc ctccacactc tctgcctcag tgggcgatag ggtcaccatt      120

acttgcagag ctagcgagtc cctggacaac tacggaatcc gcttccttac atggtttcag      180

cagaagcctg gaaaagcacc aaagctgctc atgtatgccg cttctaatca aggcagtggt      240

gtgcccagcc ggttctccgg gtctggctca ggaaccgaat ttactctgac cattagctcc      300

ttgcagcctg atgacttcgc aacatactat tgtcagcaga ccaaggaggt cccatggtct      360

tttggtcaag gcacaaaagt ggaggttaag cgtacggtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttag            714


<210>  155
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain V9 (VL-CH1)  DNA

<400>  155
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgat       60

attcagatga cccagagccc cagctctctg agcgccagcg tgggcgacag agtgaccatc      120

acctgtcggg ccagccagga catcagaaac tacctgaact ggtatcagca gaagcccggc      180

aaggccccca agctgctgat ctactacacc agcagactgg aaagcggcgt gccctccaga      240

ttttccggca gcggctccgg caccgactac accctgacca tcagcagcct gcagcccgag      300

gatttcgcca catattactg ccagcagggc aataccctgc cctggacctt cggacagggc      360

acaaaagtgg aaatcaagag cagcgcttcc accaaaggcc cttccgtgtt tcctctggct      420

cctagctcca agtccacctc tggaggcacc gctgctctcg gatgcctcgt gaaggattat      480

tttcctgagc ctgtgacagt gtcctggaat agcggagcac tgacctctgg agtgcatact      540

ttccccgctg tgctgcagtc ctctggactg tacagcctga gcagcgtggt gacagtgccc      600

agcagcagcc tgggcaccca gacctacatc tgcaacgtga accacaagcc cagcaacacc      660

aaggtggaca agaaggtgga acccaagtct tgttga                                696


<210>  156
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab-Crossfab (VH-CH1(CD33 Myelotarg)-VH-CL [V9])

<400>  156
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgcagctgg tgcagtctgg cgccgaagtg aagaaacccg gcagcagcgt gaaggtgtcc      120

tgcaaggcca gcggctacac catcaccgac agcaacatcc actgggtgcg ccaggcccct      180

ggccagtctc tggaatggat cggctacatc tacccctaca acggcggcac cgactacaac      240

cagaagttca agaaccgggc caccctgacc gtggacaacc ccaccaatac cgcctacatg      300

gaactgagca gcctgcggag cgaggacacc gccttctact actgcgtgaa cggcaacccc      360

tggctggcct attggggcca gggaacactc gtgaccgtgt ccagcgctag caccaagggc      420

cctagcgtgt tccctctggc ccctagcagc aagagcacct ctggcggaac agccgccctg      480

ggctgcctcg tgaaggacta ctttcccgag cccgtgacag tgtcctggaa ctctggcgcc      540

ctgacaagcg gcgtgcacac ctttccagcc gtgctgcagt ctagcggcct gtacagcctg      600

agcagcgtcg tgactgtgcc cagcagcagc ctgggaaccc agacctacat ctgcaacgtg      660

aaccacaagc ccagcaacac caaggtggac aagaaggtgg aacccaagag ctgcgacggc      720

ggaggcggat ccgggggagg gggatctgaa gtgcagctgg tggaaagcgg cggaggcctg      780

gtgcagcctg ggggatctct gagactgagc tgtgccgcct ccggctacag cttcaccggc      840

tacacaatga attgggtgcg gcaggctccc ggcaagggcc tggaatgggt ggccctgatc      900

aacccttaca agggcgtgtc cacctataat cagaagttta aggaccgctt caccatcagc      960

gtggacaagt ccaagaacac cgcctacctg cagatgaact ccctgcgggc cgaggataca     1020

gccgtgtact actgtgccag aagcggctac tacggcgaca gcgactggta cttcgacgtg     1080

tggggacagg gcaccctggt gaccgtgtct agtgcctctg tggccgctcc cagcgtgttc     1140

atcttcccac ctagcgacga gcagctgaag tccggcaccg cttctgtcgt gtgcctgctg     1200

aacaacttct acccccgcga ggccaaggtg cagtggaaag tggacaatgc cctgcagagc     1260

ggcaacagcc aggaaagcgt gaccgagcag gacagcaagg actccaccta cagcctgtcc     1320

agcaccctga cactgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg     1380

acccaccagg gcctgtctag ccccgtgacc aagagcttca accggggcga gtgctga        1437


<210>  157
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 VL

<400>  157

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  158
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 VH

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 


<210>  159
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CEA VH

<400>  159

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  160
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CEA VL

<400>  160

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  161
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-MCSP VH

<400>  161

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  162
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-MCSP  VL

<400>  162

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         





