                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  Bispecific T cell activating antigen binding molecules

<130>  30598

<150>  EP 11178370.0
<151>  2011-08-23

<150>  EP 12168192.8
<151>  2012-05-16

<160>  266   

<170>  PatentIn version 3.5

<210>  1
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-Fc(hole) P329G LALA

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    210                 215                 220                 


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly 
    290                 295                 300                 


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val 
305                 310                 315                 320 


Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
            340                 345                 350         


Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        355                 360                 365             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    370                 375                 380                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
385                 390                 395                 400 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                405                 410                 415     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            420                 425                 430         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        435                 440                 445             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    450                 455                 460                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
465                 470                 475                 480 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                485                 490                 495     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            500                 505                 510         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        515                 520                 525             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    530                 535                 540                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
545                 550                 555                 560 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                565                 570                 575     


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            580                 585                 590         


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
        595                 600                 605             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
    610                 615                 620                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
625                 630                 635                 640 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                645                 650                 655     


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            660                 665                 670         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        675                 680                 685             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695                 700 


<210>  2
<211>  2103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-Fc(hole) P329G LALA

<400>  2
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagtc cggcaccgcc agcgtcgtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcagcggcgg aggctctgga      660

ggcggctctg aaggcggagg aagtgagggc ggaggctcag aaggcggcgg aagcgaaggt      720

ggcggctctg gcggcggatc cggcgaggtg cagctggtcg agtccggcgg aggcctggtg      780

cagcctggcg gcagcctgag actgagctgc gccgccagcg gctacagctt caccggctac      840

accatgaact gggtccggca ggctcctggc aagggcctcg aatgggtggc cctgatcaac      900

ccctacaagg gcgtgagcac ctacaaccag aagttcaagg accggttcac catcagcgtg      960

gacaagagca agaacaccgc ctatctgcag atgaacagcc tgcgggccga ggacaccgcc     1020

gtgtactact gcgccagaag cggctactac ggcgacagcg actggtactt cgacgtgtgg     1080

ggccagggca cactggtcac cgtgtccagc gctagcacca agggcccatc ggtcttcccc     1140

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag     1200

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg     1260

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc     1320

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc     1380

aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca cacatgccca     1440

ccgtgcccag cacctgaagc tgcaggggga ccgtcagtct tcctcttccc cccaaaaccc     1500

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1560

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1620

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1680

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1740

ctcggcgccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1800

gtgtgcaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctctcgtgc     1860

gcagtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1920

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctcgtg     1980

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     2040

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     2100

tga                                                                   2103


<210>  3
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(knob) P329G LALA

<400>  3

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  4
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(knob) P329G LALA

<400>  4
gaggtccagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaagctgga atggatgggc tacataacct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc ggactttgac      300

tactggggcc aaggcaccac tctcacagtc tcctcagcta gcaccaaggg cccatcggtc      360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      480

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      600

cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa gacccacacc      660

tgtccccctt gccctgcccc tgaagctgct ggtggccctt ccgtgttcct gttcccccca      720

aagcccaagg acaccctgat gatcagccgg acccccgaag tgacctgcgt ggtggtcgat      780

gtgtcccacg aggaccctga agtgaagttc aattggtacg tggacggcgt ggaagtgcac      840

aatgccaaga ccaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcg gcgcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatgccgg gatgagctga ccaagaacca ggtcagcctg     1080

tggtgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaataa                                                             1329


<210>  5
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 (VL-CL)

<400>  5

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  6
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 (VL-CL)

<400>  6
gatattgtgc tcacacagtc tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattaga aattatttaa actggtatca gcagagacca      120

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  7
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 (scFab)-Fc(hole) P329G LALA

<400>  7

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    210                 215                 220                 


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Gln Glu Ser Gly 
                245                 250                 255     


Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val 
            260                 265                 270         


Thr Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln 
        275                 280                 285             


Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr Asp Gly 
    290                 295                 300                 


Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg 
305                 310                 315                 320 


Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr 
                325                 330                 335     


Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln 
            340                 345                 350         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        355                 360                 365             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    370                 375                 380                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
385                 390                 395                 400 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                405                 410                 415     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            420                 425                 430         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        435                 440                 445             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Gln Asp Lys Thr 
465                 470                 475                 480 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
                485                 490                 495     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            500                 505                 510         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        515                 520                 525             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    530                 535                 540                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
545                 550                 555                 560 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                565                 570                 575     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            580                 585                 590         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
        595                 600                 605             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    610                 615                 620                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
625                 630                 635                 640 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                645                 650                 655     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            660                 665                 670         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        675                 680                 685             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695                 700                 


<210>  8
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 (scFab)-Fc(hole) P329G LALA

<400>  8
gacatcgtgc tgacccagag ccctagcagc ctgagcgcca gcctgggcga cagagtgacc       60

atcagctgta gcgcctccca gggcatcaga aactacctga actggtatca gcagagaccc      120

gacggcacag tgaagctgct gatctactac accagcagcc tgcacagcgg cgtgccaagc      180

agattcagcg gcagcggctc cggcacagac tacagcctga ccatctccaa cctggaaccc      240

gaggatatcg ccacctacta ctgccagcag tacagcaagc tgccctggac cttcggcgga      300

ggcaccaagc tggaaatcaa gcggaccgtg gccgctccca gcgtgttcat cttcccaccc      360

agcgacgagc agctgaagtc cggcacagcc agcgtcgtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgtccag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac cggggcgagt gtagtggcgg aggctctggc      660

ggaggaagcg agggcggagg atctgaaggc ggcggatctg aggggggagg cagtgaaggg      720

ggaggctcag ggggaggatc cggcgaggtg cagctgcagg aatctggccc tggcctggtc      780

aagccaagcc agagtctgag cctgacctgc agcgtgaccg gctacagcat taccagcggc      840

tactactgga actggattcg gcagttcccc ggcaataagc tggaatggat gggctacatc      900

acctacgacg gcagcaacaa ctacaacccc agcctgaaga accggatcag catcacccgg      960

gacaccagca agaaccagtt cttcctgaag ctgaacagcg tgaccaccga ggacaccgcc     1020

acatactatt gcgccgactt cgactactgg ggccagggca ccaccctgac cgtgtccagc     1080

gccagcacaa agggccctag cgtgttccct ctggccccca gcagcaagag cacaagcggc     1140

ggaacagccg ccctgggctg cctcgtgaag gactacttcc ccgagcccgt gacagtgtct     1200

tggaacagcg gagccctgac aagcggcgtg cacaccttcc ctgccgtgct gcagagcagc     1260

ggcctgtact ccctgagcag cgtggtcacc gtgcctagca gcagcctggg cacccagacc     1320

tacatctgca acgtgaacca caagcccagc aacaccaaag tggacaagaa ggtggagccc     1380

aagagctgtg atggcggagg agggtccgga ggcggtggat ccggagctca ggacaaaact     1440

cacacatgcc caccgtgccc agcacctgaa gctgcagggg gaccgtcagt cttcctcttc     1500

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     1560

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1620

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1680

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1740

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1800

cgagaaccac aggtgtgcac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1860

agcctctcgt gcgcagtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1920

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1980

ttcttcctcg tgagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     2040

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     2100

tctccgggta aatga                                                      2115


<210>  9
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (VH-CH1) -Fc(knob) LALA

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Gln Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  10
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (VH-CH1) -Fc(knob) LALA

<400>  10
gaggtgcagc tggtcgagag cggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggcta cagcttcacc ggctacacca tgaactgggt ccggcaggca      120

cctggcaagg gactggaatg ggtggccctg atcaacccct acaagggcgt gagcacctac      180

aaccagaagt tcaaggaccg gttcaccatc agcgtggaca agagcaagaa caccgcctat      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaagcggc      300

tactacggcg acagcgactg gtacttcgac gtgtggggcc agggcaccct cgtgaccgtg      360

tctagcgcta gcaccaaggg cccctccgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgctct gggctgcctg gtcaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag      540

agttctggcc tgtatagcct gagcagcgtg gtcaccgtgc cttctagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gagcccaaga gctgcgacgg cggtggtggc tccggaggcg gtggatccgg agctcaggac      720

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      840

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      900

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      960

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1020

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1080

cagccccgag aaccacaggt gtacaccctg cccccatgcc gggatgagct gaccaagaac     1140

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1200

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1260

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380

tccctgtctc cgggtaaatg a                                               1401


<210>  11
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (VL-CL)

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  12
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (VL-CL)

<400>  12
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tgccctggac cttcggccag      300

ggcacaaagg tggagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  13
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-LC007 (VH-CH1)-Fc(knob) wt

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    210                 215                 220                 


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly 
    290                 295                 300                 


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val 
305                 310                 315                 320 


Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
            340                 345                 350         


Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        355                 360                 365             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    370                 375                 380                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
385                 390                 395                 400 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                405                 410                 415     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            420                 425                 430         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        435                 440                 445             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    450                 455                 460                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
                485                 490                 495     


Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser 
            500                 505                 510         


Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn 
        515                 520                 525             


Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr 
    530                 535                 540                 


Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
545                 550                 555                 560 


Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 
                565                 570                 575     


Thr Tyr Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            580                 585                 590         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        595                 600                 605             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    610                 615                 620                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
625                 630                 635                 640 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                645                 650                 655     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            660                 665                 670         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        675                 680                 685             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    690                 695                 700                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
705                 710                 715                 720 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                725                 730                 735     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            740                 745                 750         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        755                 760                 765             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    770                 775                 780                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
785                 790                 795                 800 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                805                 810                 815     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            820                 825                 830         


Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        835                 840                 845             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    850                 855                 860                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
865                 870                 875                 880 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                885                 890                 895     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            900                 905                 910         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        915                 920                 925     


<210>  14
<211>  2781
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-LC007 (VH-CH1)-Fc(knob) wt

<400>  14
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagtc cggcaccgcc agcgtcgtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcagcggcgg aggctctgga      660

ggcggctctg aaggcggagg aagtgagggc ggaggctcag aaggcggcgg aagcgaaggt      720

ggcggctctg gcggcggatc cggcgaggtg cagctggtcg agtccggcgg aggcctggtg      780

cagcctggcg gcagcctgag actgagctgc gccgccagcg gctacagctt caccggctac      840

accatgaact gggtccggca ggctcctggc aagggcctcg aatgggtggc cctgatcaac      900

ccctacaagg gcgtgagcac ctacaaccag aagttcaagg accggttcac catcagcgtg      960

gacaagagca agaacaccgc ctatctgcag atgaacagcc tgcgggccga ggacaccgcc     1020

gtgtactact gcgccagaag cggctactac ggcgacagcg actggtactt cgacgtgtgg     1080

ggccagggca cactggtcac cgtgtccagc gctagcacca agggcccctc cgtgttcccc     1140

ctggccccca gcagcaagag caccagcggc ggcacagccg ccctcggctg cctggtcaag     1200

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gagccctgac ctccggcgtg     1260

cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgtccag cgtggtcacc     1320

gtgccctcca gcagcctggg cacccagacc tacatctgca acgtgaacca caagcccagc     1380

aataccaagg tggacaagaa ggtggagccc aagagctgcg acggcggtgg tggctccgga     1440

ggcggtggat ctgaagtgca gctgcaggaa agcggccctg gcctggtcaa gcccagccag     1500

agcctgagcc tgacctgtag cgtgaccggc tactccatca cctccggcta ctactggaat     1560

tggattcggc agttccccgg caacaagctg gaatggatgg gctacatcac ctacgacggc     1620

agcaacaact acaaccccag cctgaagaac cggatcagca tcacccggga caccagcaag     1680

aaccagttct tcctgaagtt gaattctgtg actactgagg acacagctac atattactgt     1740

gcggactttg actactgggg ccaaggcacc actctcacag tctcctcagc tagcaccaag     1800

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     1860

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc     1920

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     1980

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     2040

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac     2100

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc     2160

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     2220

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     2280

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     2340

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     2400

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     2460

cagccccgag aaccacaggt gtacaccctg cccccatgcc gggatgagct gaccaagaac     2520

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     2580

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     2640

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     2700

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     2760

tccctgtctc cgggtaaatg a                                               2781


<210>  15
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(hole) wt

<400>  15

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  16
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(hole) wt

<400>  16
gaggtccagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaagctgga atggatgggc tacataacct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc ggactttgac      300

tactggggcc aaggcaccac tctcacagtc tcctcagcta gcaccaaggg cccaagcgtg      360

ttccctctgg cccccagcag caagagcaca agcggcggaa cagccgccct gggctgcctg      420

gtcaaggact acttccccga gcccgtgaca gtgtcctgga acagcggagc cctgaccagc      480

ggcgtgcaca cctttccagc cgtgctgcag agcagcggcc tgtacagcct gagcagcgtg      540

gtcacagtgc ctagcagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      600

cccagcaaca ccaaggtgga caagaaggtg gagcccaaga gctgcgacaa gacccacacc      660

tgtccccctt gtcctgcccc tgagctgctg ggcggaccca gcgtgttcct gttcccccca      720

aagcccaagg acaccctgat gatcagccgg acccccgaag tgacctgcgt ggtggtggac      780

gtgtcccacg aggaccctga agtgaagttc aattggtacg tggacggcgt ggaggtgcac      840

aatgccaaga ccaagccccg ggaggaacag tacaacagca cctaccgggt ggtgtccgtg      900

ctgaccgtgc tgcaccagga ctggctgaac ggcaaagagt acaagtgcaa ggtctccaac      960

aaggccctgc ctgcccccat cgagaaaacc atcagcaagg ccaagggcca gcccagagaa     1020

ccccaggtgt gcaccctgcc ccccagcaga gatgagctga ccaagaacca ggtgtccctg     1080

agctgtgccg tcaagggctt ctaccccagc gatatcgccg tggagtggga gagcaacggc     1140

cagcctgaga acaactacaa gaccaccccc cctgtgctgg acagcgacgg cagcttcttc     1200

ctggtgtcca aactgaccgt ggacaagagc cggtggcagc agggcaacgt gttcagctgc     1260

agcgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgag cctgagcccc     1320

ggcaagtga                                                             1329


<210>  17
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-LC007 (VH-CH1)-Fc(knob) LALA

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    210                 215                 220                 


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly 
    290                 295                 300                 


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val 
305                 310                 315                 320 


Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
            340                 345                 350         


Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        355                 360                 365             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    370                 375                 380                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
385                 390                 395                 400 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                405                 410                 415     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            420                 425                 430         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        435                 440                 445             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    450                 455                 460                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
                485                 490                 495     


Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser 
            500                 505                 510         


Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn 
        515                 520                 525             


Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr 
    530                 535                 540                 


Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
545                 550                 555                 560 


Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 
                565                 570                 575     


Thr Tyr Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            580                 585                 590         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        595                 600                 605             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    610                 615                 620                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
625                 630                 635                 640 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                645                 650                 655     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            660                 665                 670         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        675                 680                 685             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    690                 695                 700                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
705                 710                 715                 720 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                725                 730                 735     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            740                 745                 750         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        755                 760                 765             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    770                 775                 780                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
785                 790                 795                 800 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                805                 810                 815     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            820                 825                 830         


Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        835                 840                 845             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    850                 855                 860                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
865                 870                 875                 880 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                885                 890                 895     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            900                 905                 910         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        915                 920                 925     


<210>  18
<211>  2781
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-LC007 (VH-CH1)-Fc(knob) LALA

<400>  18
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagtc cggcaccgcc agcgtcgtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcagcggcgg aggctctgga      660

ggcggctctg aaggcggagg aagtgagggc ggaggctcag aaggcggcgg aagcgaaggt      720

ggcggctctg gcggcggatc cggcgaggtg cagctggtcg agtccggcgg aggcctggtg      780

cagcctggcg gcagcctgag actgagctgc gccgccagcg gctacagctt caccggctac      840

accatgaact gggtccggca ggctcctggc aagggcctcg aatgggtggc cctgatcaac      900

ccctacaagg gcgtgagcac ctacaaccag aagttcaagg accggttcac catcagcgtg      960

gacaagagca agaacaccgc ctatctgcag atgaacagcc tgcgggccga ggacaccgcc     1020

gtgtactact gcgccagaag cggctactac ggcgacagcg actggtactt cgacgtgtgg     1080

ggccagggca cactggtcac cgtgtccagc gctagcacca agggcccctc cgtgttcccc     1140

ctggccccca gcagcaagag caccagcggc ggcacagccg ccctcggctg cctggtcaag     1200

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gagccctgac ctccggcgtg     1260

cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgtccag cgtggtcacc     1320

gtgccctcca gcagcctggg cacccagacc tacatctgca acgtgaacca caagcccagc     1380

aataccaagg tggacaagaa ggtggagccc aagagctgcg acggcggtgg tggctccgga     1440

ggcggtggat ctgaagtgca gctgcaggaa agcggccctg gcctggtcaa gcccagccag     1500

agcctgagcc tgacctgtag cgtgaccggc tactccatca cctccggcta ctactggaat     1560

tggattcggc agttccccgg caacaagctg gaatggatgg gctacatcac ctacgacggc     1620

agcaacaact acaaccccag cctgaagaac cggatcagca tcacccggga caccagcaag     1680

aaccagttct tcctgaagtt gaattctgtg actactgagg acacagctac atattactgt     1740

gcggactttg actactgggg ccaaggcacc actctcacag tctcctcagc tagcaccaag     1800

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     1860

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc     1920

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     1980

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     2040

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac     2100

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc     2160

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     2220

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     2280

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     2340

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     2400

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     2460

cagccccgag aaccacaggt gtacaccctg cccccatgcc gggatgagct gaccaagaac     2520

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     2580

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     2640

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     2700

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     2760

tccctgtctc cgggtaaatg a                                               2781


<210>  19
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(hole) LALA

<400>  19

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  20
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(hole) LALA

<400>  20
gaggtccagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaagctgga atggatgggc tacataacct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc ggactttgac      300

tactggggcc aaggcaccac tctcacagtc tcctcagcta gcaccaaggg cccatcggtc      360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      480

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      600

cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaagctgca gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt gcaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctc     1080

tcgtgcgcag tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctcgtgagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaatga                                                             1329


<210>  21
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-LC007 (VH-CH1)-Fc(knob) P329G LALA

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    210                 215                 220                 


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly 
    290                 295                 300                 


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val 
305                 310                 315                 320 


Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
            340                 345                 350         


Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        355                 360                 365             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    370                 375                 380                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
385                 390                 395                 400 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                405                 410                 415     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            420                 425                 430         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        435                 440                 445             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    450                 455                 460                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
                485                 490                 495     


Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser 
            500                 505                 510         


Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn 
        515                 520                 525             


Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr 
    530                 535                 540                 


Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
545                 550                 555                 560 


Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 
                565                 570                 575     


Thr Tyr Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            580                 585                 590         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        595                 600                 605             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    610                 615                 620                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
625                 630                 635                 640 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                645                 650                 655     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            660                 665                 670         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        675                 680                 685             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    690                 695                 700                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
705                 710                 715                 720 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                725                 730                 735     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            740                 745                 750         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        755                 760                 765             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    770                 775                 780                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
785                 790                 795                 800 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                805                 810                 815     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            820                 825                 830         


Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        835                 840                 845             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    850                 855                 860                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
865                 870                 875                 880 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                885                 890                 895     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            900                 905                 910         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        915                 920                 925     


<210>  22
<211>  2781
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-LC007 (VH-CH1)-Fc(knob) P329G LALA

<400>  22
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagtc cggcaccgcc agcgtcgtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcagcggcgg aggctctgga      660

ggcggctctg aaggcggagg aagtgagggc ggaggctcag aaggcggcgg aagcgaaggt      720

ggcggctctg gcggcggatc cggcgaggtg cagctggtcg agtccggcgg aggcctggtg      780

cagcctggcg gcagcctgag actgagctgc gccgccagcg gctacagctt caccggctac      840

accatgaact gggtccggca ggctcctggc aagggcctcg aatgggtggc cctgatcaac      900

ccctacaagg gcgtgagcac ctacaaccag aagttcaagg accggttcac catcagcgtg      960

gacaagagca agaacaccgc ctatctgcag atgaacagcc tgcgggccga ggacaccgcc     1020

gtgtactact gcgccagaag cggctactac ggcgacagcg actggtactt cgacgtgtgg     1080

ggccagggca cactggtcac cgtgtccagc gctagcacca agggcccctc cgtgttcccc     1140

ctggccccca gcagcaagag caccagcggc ggcacagccg ccctcggctg cctggtcaag     1200

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gagccctgac ctccggcgtg     1260

cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgtccag cgtggtcacc     1320

gtgccctcca gcagcctggg cacccagacc tacatctgca acgtgaacca caagcccagc     1380

aataccaagg tggacaagaa ggtggagccc aagagctgcg acggcggtgg tggctccgga     1440

ggcggtggat ctgaagtgca gctgcaggaa agcggccctg gcctggtcaa gcccagccag     1500

agcctgagcc tgacctgtag cgtgaccggc tactccatca cctccggcta ctactggaat     1560

tggattcggc agttccccgg caacaagctg gaatggatgg gctacatcac ctacgacggc     1620

agcaacaact acaaccccag cctgaagaac cggatcagca tcacccggga caccagcaag     1680

aaccagttct tcctgaagtt gaattctgtg actactgagg acacagctac atattactgt     1740

gcggactttg actactgggg ccaaggcacc actctcacag tctcctcagc tagcaccaag     1800

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     1860

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc     1920

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     1980

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     2040

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac     2100

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc     2160

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     2220

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     2280

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     2340

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     2400

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     2460

cagccccgag aaccacaggt gtacaccctg cccccatgcc gggatgagct gaccaagaac     2520

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     2580

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     2640

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     2700

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     2760

tccctgtctc cgggtaaatg a                                               2781


<210>  23
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(hole) P329G LALA

<400>  23

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  24
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(hole) P329G LALA

<400>  24
gaggtccagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaagctgga atggatgggc tacataacct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc ggactttgac      300

tactggggcc aaggcaccac tctcacagtc tcctcagcta gcaccaaggg cccatcggtc      360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      480

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      600

cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaagctgca gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcg gcgcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt gcaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctc     1080

tcgtgcgcag tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctcgtgagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaatga                                                             1329


<210>  25
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-LC007 (VH-CH1)-Fc(knob) P329G LALA N297D

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    210                 215                 220                 


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly 
    290                 295                 300                 


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val 
305                 310                 315                 320 


Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
            340                 345                 350         


Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        355                 360                 365             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    370                 375                 380                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
385                 390                 395                 400 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                405                 410                 415     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            420                 425                 430         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        435                 440                 445             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    450                 455                 460                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
                485                 490                 495     


Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser 
            500                 505                 510         


Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn 
        515                 520                 525             


Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr 
    530                 535                 540                 


Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
545                 550                 555                 560 


Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 
                565                 570                 575     


Thr Tyr Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            580                 585                 590         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        595                 600                 605             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    610                 615                 620                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
625                 630                 635                 640 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                645                 650                 655     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            660                 665                 670         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        675                 680                 685             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    690                 695                 700                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
705                 710                 715                 720 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                725                 730                 735     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            740                 745                 750         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        755                 760                 765             


Lys Pro Arg Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val 
    770                 775                 780                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
785                 790                 795                 800 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                805                 810                 815     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            820                 825                 830         


Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        835                 840                 845             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    850                 855                 860                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
865                 870                 875                 880 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                885                 890                 895     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            900                 905                 910         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        915                 920                 925     


<210>  26
<211>  2781
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-LC007 (VH-CH1)-Fc(knob) P329G LALA N297D

<400>  26
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagtc cggcaccgcc agcgtcgtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcagcggcgg aggctctgga      660

ggcggctctg aaggcggagg aagtgagggc ggaggctcag aaggcggcgg aagcgaaggt      720

ggcggctctg gcggcggatc cggcgaggtg cagctggtcg agtccggcgg aggcctggtg      780

cagcctggcg gcagcctgag actgagctgc gccgccagcg gctacagctt caccggctac      840

accatgaact gggtccggca ggctcctggc aagggcctcg aatgggtggc cctgatcaac      900

ccctacaagg gcgtgagcac ctacaaccag aagttcaagg accggttcac catcagcgtg      960

gacaagagca agaacaccgc ctatctgcag atgaacagcc tgcgggccga ggacaccgcc     1020

gtgtactact gcgccagaag cggctactac ggcgacagcg actggtactt cgacgtgtgg     1080

ggccagggca cactggtcac cgtgtccagc gctagcacca agggcccctc cgtgttcccc     1140

ctggccccca gcagcaagag caccagcggc ggcacagccg ccctcggctg cctggtcaag     1200

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gagccctgac ctccggcgtg     1260

cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgtccag cgtggtcacc     1320

gtgccctcca gcagcctggg cacccagacc tacatctgca acgtgaacca caagcccagc     1380

aataccaagg tggacaagaa ggtggagccc aagagctgcg acggcggtgg tggctccgga     1440

ggcggtggat ctgaagtgca gctgcaggaa agcggccctg gcctggtcaa gcccagccag     1500

agcctgagcc tgacctgtag cgtgaccggc tactccatca cctccggcta ctactggaat     1560

tggattcggc agttccccgg caacaagctg gaatggatgg gctacatcac ctacgacggc     1620

agcaacaact acaaccccag cctgaagaac cggatcagca tcacccggga caccagcaag     1680

aaccagttct tcctgaagtt gaattctgtg actactgagg acacagctac atattactgt     1740

gcggactttg actactgggg ccaaggcacc actctcacag tctcctcagc tagcaccaag     1800

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     1860

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc     1920

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     1980

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     2040

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac     2100

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc     2160

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     2220

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     2280

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgacag cacgtaccgt     2340

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     2400

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     2460

cagccccgag aaccacaggt gtacaccctg cccccatgcc gggatgagct gaccaagaac     2520

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     2580

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     2640

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     2700

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     2760

tccctgtctc cgggtaaatg a                                               2781


<210>  27
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(hole) P329G LALA N297D

<400>  27

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  28
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 (VH-CH1)-Fc(hole) P329G LALA N297D

<400>  28
gaggtccagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaagctgga atggatgggc tacataacct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc ggactttgac      300

tactggggcc aaggcaccac tctcacagtc tcctcagcta gcaccaaggg cccatcggtc      360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      480

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      600

cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaagctgca gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacgacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcg gcgcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt gcaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctc     1080

tcgtgcgcag tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctcgtgagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaatga                                                             1329


<210>  29
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (VL-CH1)-LC007 (VH-CH1)-Fc(hole) P329G LALA

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    210                 215                 220                 


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu 
225                 230                 235                 240 


Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
                245                 250                 255     


Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly 
            260                 265                 270         


Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
        275                 280                 285             


Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys 
    290                 295                 300                 


Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Asp 
305                 310                 315                 320 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser 
                325                 330                 335     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            340                 345                 350         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        355                 360                 365             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    370                 375                 380                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
385                 390                 395                 400 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                405                 410                 415     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            420                 425                 430         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        435                 440                 445             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    450                 455                 460                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
465                 470                 475                 480 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                485                 490                 495     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            500                 505                 510         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        515                 520                 525             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    530                 535                 540                 


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
545                 550                 555                 560 


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                565                 570                 575     


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
            580                 585                 590         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        595                 600                 605             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
    610                 615                 620                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
625                 630                 635                 640 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                645                 650                 655     


Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 


<210>  30
<211>  1995
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (VL-CH1)-LC007 (VH-CH1)-Fc(hole) P329G LALA

<400>  30
gatatccaga tgacccagag ccccagctct ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagac tggaaagcgg cgtgccctcc      180

agattttccg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggatttcg ccacatatta ctgccagcag ggcaataccc tgccctggac cttcggacag      300

ggcacaaaag tggaaatcaa gagcagcgct tccaccaaag gcccttccgt gtttcctctg      360

gctcctagct ccaagtccac ctctggaggc accgctgctc tcggatgcct cgtgaaggat      420

tattttcctg agcctgtgac agtgtcctgg aatagcggag cactgacctc tggagtgcat      480

actttccccg ctgtgctgca gtcctctgga ctgtacagcc tgagcagcgt ggtgacagtg      540

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaac      600

accaaggtgg acaagaaggt ggaacccaag tcttgtggcg gaggcggatc cggcggaggg      660

ggatctgagg tgcagctgca ggaaagcggc cctggcctgg tgaaacccag ccagagcctg      720

agcctgacct gcagcgtgac cggctacagc atcaccagcg gctactactg gaactggatc      780

agacagttcc ccggcaacaa gctggaatgg atgggctaca tcacctacga cggcagcaac      840

aactacaacc ccagcctgaa gaacagaatc agcatcaccc gggacaccag caagaaccag      900

ttcttcctga agctgaacag cgtgaccacc gaggacaccg ccacctacta ctgcgccgac      960

ttcgactact ggggccaggg caccaccctg accgtgtcct ccgcctctac caagggcccc     1020

agcgtgttcc ccctggcacc cagcagcaag agcacatctg gcggaacagc cgctctgggc     1080

tgtctggtga aagactactt ccccgagccc gtgaccgtgt cttggaactc tggcgccctg     1140

accagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctccctgtcc     1200

tccgtggtca ccgtgccctc tagctccctg ggaacacaga catatatctg taatgtcaat     1260

cacaagcctt ccaacaccaa agtcgataag aaagtcgagc ccaagagctg cgacaaaact     1320

cacacatgcc caccgtgccc agcacctgaa gctgcagggg gaccgtcagt cttcctcttc     1380

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     1440

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1500

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1560

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1620

tccaacaaag ccctcggcgc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1680

cgagaaccac aggtgtgcac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1740

agcctctcgt gcgcagtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1800

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1860

ttcttcctcg tgagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1920

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1980

tctccgggta aatga                                                      1995


<210>  31
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(knob) wt

<400>  31

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Ser Gly 
225                 


<210>  32
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(knob) wt

<400>  32
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gccgggatga gctgaccaag      420

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa atccggatga                                       690


<210>  33
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (VH-CL)

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys 
225                 


<210>  34
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (VH-CL)

<400>  34
gaggtgcagc tggtcgagag cggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggcta cagcttcacc ggctacacca tgaactgggt ccggcaggca      120

cctggcaagg gactggaatg ggtggccctg atcaacccct acaagggcgt gagcacctac      180

aaccagaagt tcaaggaccg gttcaccatc agcgtggaca agagcaagaa caccgcctat      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaagcggc      300

tactacggcg acagcgactg gtacttcgac gtgtggggcc agggcaccct cgtgaccgtg      360

tctagcgcta gcgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      420

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa      480

gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag      540

caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac      600

tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc      660

acaaagagct tcaacagggg agagtgttga                                       690


<210>  35
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FN18 (VL-CH1)-LC007 (VH-CH1)-Fc(hole) P329G LALA

<400>  35

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Asn Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
225                 230                 235                 240 


Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser 
                245                 250                 255     


Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn 
            260                 265                 270         


Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr 
        275                 280                 285             


Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
    290                 295                 300                 


Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 
305                 310                 315                 320 


Thr Tyr Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                325                 330                 335     


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
            340                 345                 350         


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
        355                 360                 365             


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
    370                 375                 380                 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
385                 390                 395                 400 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
                405                 410                 415     


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
            420                 425                 430         


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        435                 440                 445             


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
    450                 455                 460                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
465                 470                 475                 480 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                485                 490                 495     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            500                 505                 510         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        515                 520                 525             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    530                 535                 540                 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
545                 550                 555                 560 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
                565                 570                 575     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
            580                 585                 590         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        595                 600                 605             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    610                 615                 620                 


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
625                 630                 635                 640 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                645                 650                 655     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665                 670 


<210>  36
<211>  2013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FN18 (VL-CH1)-LC007 (VH-CH1)-Fc(hole) P329G LALA

<400>  36
gacatcgtga tgagccagag ccccagcagc ctggccgtgt ccgtgggcga gaaagtgacc       60

atgagctgca agagcagcca gagcctgctg tactcctcta accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagtccccc aagctgctga tcaactgggc cagcacccgc      180

gagagcggcg tgcccgatag attcacaggc agcggcagcc ggaccgactt caccctgacc      240

atcagcagcg tgaaggccga ggatctggcc gtgtacttct gccagcagtt ctacagctac      300

ccccccacct tcggcggagg cacgaagctg gaaatcaaga gcagcgcttc caccaaaggc      360

ccttccgtgt ttcctctggc tcctagctcc aagtccacct ctggaggcac cgctgctctc      420

ggatgcctcg tgaaggatta ttttcctgag cctgtgacag tgtcctggaa tagcggagca      480

ctgacctctg gagtgcatac tttccccgct gtgctgcagt cctctggact gtacagcctg      540

agcagcgtgg tgacagtgcc cagcagcagc ctgggcaccc agacctacat ctgcaacgtg      600

aaccacaagc ccagcaacac caaggtggac aagaaggtgg aacccaagtc ttgtggcgga      660

ggcggatccg gcggaggggg atctgaggtg cagctgcagg aaagcggccc tggcctggtg      720

aaacccagcc agagcctgag cctgacctgc agcgtgaccg gctacagcat caccagcggc      780

tactactgga actggatcag acagttcccc ggcaacaagc tggaatggat gggctacatc      840

acctacgacg gcagcaacaa ctacaacccc agcctgaaga acagaatcag catcacccgg      900

gacaccagca agaaccagtt cttcctgaag ctgaacagcg tgaccaccga ggacaccgcc      960

acctactact gcgccgactt cgactactgg ggccagggca ccaccctgac cgtgtcctcc     1020

gcctctacca agggccccag cgtgttcccc ctggcaccca gcagcaagag cacatctggc     1080

ggaacagccg ctctgggctg tctggtgaaa gactacttcc ccgagcccgt gaccgtgtct     1140

tggaactctg gcgccctgac cagcggcgtg cacacctttc cagccgtgct gcagagcagc     1200

ggcctgtact ccctgtcctc cgtggtcacc gtgccctcta gctccctggg aacacagaca     1260

tatatctgta atgtcaatca caagccttcc aacaccaaag tcgataagaa agtcgagccc     1320

aagagctgcg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgcaggggga     1380

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1440

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1500

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1560

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1620

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1680

aaagccaaag ggcagccccg agaaccacag gtgtgcaccc tgcccccatc ccgggatgag     1740

ctgaccaaga accaggtcag cctctcgtgc gcagtcaaag gcttctatcc cagcgacatc     1800

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1860

ctggactccg acggctcctt cttcctcgtg agcaagctca ccgtggacaa gagcaggtgg     1920

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1980

cagaagagcc tctccctgtc tccgggtaaa tga                                  2013


<210>  37
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FN18 (VH-CL)

<400>  37

Gln Val Gln Leu Gln Gln Ser Glu Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Ile His Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Ser Ser Glu Ser Thr Glu Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Asp Arg Thr Ile Leu Thr Ala Asp Arg Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Lys Gly Glu Lys Leu Leu Gly Asn Arg Tyr Trp Tyr Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Ser Val Thr Val Ser Ser Ala Ser Val Ala 
        115                 120                 125             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
    130                 135                 140                 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
145                 150                 155                 160 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
                165                 170                 175     


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
            180                 185                 190         


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
        195                 200                 205             


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
    210                 215                 220                 


Ser Phe Asn Arg Gly Glu Cys 
225                 230     


<210>  38
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FN18 (VH-CL)

<400>  38
caggtgcagc tgcagcagag cgaggccgag ctggctagac ctggagccag cgtgaagatg       60

agctgcaagg ccagcggcta caccttcacc gactacacca tccactggct gaagcagcgg      120

cctggacagg gcctggactg gatcggctac ttcaacccca gcagcgagag caccgagtac      180

aaccggaagt tcaaggaccg gaccatcctg accgccgaca gaagcagcac caccgcctac      240

atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcag ccggaagggc      300

gagaagctgc tgggcaacag atactggtac ttcgacgtgt ggggagccgg caccagcgtg      360

accgtgtcta gcgctagcgt ggctgcacca tctgtcttca tcttcccgcc atctgatgag      420

cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag      480

gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc      540

acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa      600

gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg      660

cccgtcacaa agagcttcaa caggggagag tgttga                                696


<210>  39
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C11 (VL-CH1)-LC007 (VH-CH1)-Fc(hole) P329G LALA

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Pro Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Asn Lys Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Ser Ser Phe Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Gly Ser Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    210                 215                 220                 


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu 
225                 230                 235                 240 


Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
                245                 250                 255     


Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly 
            260                 265                 270         


Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
        275                 280                 285             


Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys 
    290                 295                 300                 


Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Asp 
305                 310                 315                 320 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser 
                325                 330                 335     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            340                 345                 350         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        355                 360                 365             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    370                 375                 380                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
385                 390                 395                 400 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                405                 410                 415     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            420                 425                 430         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        435                 440                 445             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    450                 455                 460                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
465                 470                 475                 480 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                485                 490                 495     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            500                 505                 510         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        515                 520                 525             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    530                 535                 540                 


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
545                 550                 555                 560 


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                565                 570                 575     


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
            580                 585                 590         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        595                 600                 605             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
    610                 615                 620                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
625                 630                 635                 640 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                645                 650                 655     


Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 


<210>  40
<211>  1995
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C11 (VL-CH1)-LC007 (VH-CH1)-Fc(hole) P329G LALA

<400>  40
gacatccaga tgacccagag ccccagcagc ctgcctgcca gcctgggcga cagagtgacc       60

atcaactgcc aggccagcca ggacatcagc aactacctga actggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctactac accaacaagc tggccgacgg cgtgcccagc      180

agattcagcg gcagcggctc cggcagagac agcagcttca ccatctccag cctggaaagc      240

gaggacatcg gcagctacta ctgccagcag tactacaact acccctggac cttcggccct      300

ggcaccaagc tggaaatcaa gagcagcgct tccaccaaag gcccttccgt gtttcctctg      360

gctcctagct ccaagtccac ctctggaggc accgctgctc tcggatgcct cgtgaaggat      420

tattttcctg agcctgtgac agtgtcctgg aatagcggag cactgacctc tggagtgcat      480

actttccccg ctgtgctgca gtcctctgga ctgtacagcc tgagcagcgt ggtgacagtg      540

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaac      600

accaaggtgg acaagaaggt ggaacccaag tcttgtggcg gaggcggatc cggcggaggg      660

ggatctgagg tgcagctgca ggaaagcggc cctggcctgg tgaaacccag ccagagcctg      720

agcctgacct gcagcgtgac cggctacagc atcaccagcg gctactactg gaactggatc      780

agacagttcc ccggcaacaa gctggaatgg atgggctaca tcacctacga cggcagcaac      840

aactacaacc ccagcctgaa gaacagaatc agcatcaccc gggacaccag caagaaccag      900

ttcttcctga agctgaacag cgtgaccacc gaggacaccg ccacctacta ctgcgccgac      960

ttcgactact ggggccaggg caccaccctg accgtgtcct ccgcctctac caagggcccc     1020

agcgtgttcc ccctggcacc cagcagcaag agcacatctg gcggaacagc cgctctgggc     1080

tgtctggtga aagactactt ccccgagccc gtgaccgtgt cttggaactc tggcgccctg     1140

accagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctccctgtcc     1200

tccgtggtca ccgtgccctc tagctccctg ggaacacaga catatatctg taatgtcaat     1260

cacaagcctt ccaacaccaa agtcgataag aaagtcgagc ccaagagctg cgacaaaact     1320

cacacatgcc caccgtgccc agcacctgaa gctgcagggg gaccgtcagt cttcctcttc     1380

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     1440

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1500

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1560

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1620

tccaacaaag ccctcggcgc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1680

cgagaaccac aggtgtgcac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1740

agcctctcgt gcgcagtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1800

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1860

ttcttcctcg tgagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1920

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1980

tctccgggta aatga                                                      1995


<210>  41
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C11 (VH-CL)

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Ser Val 
        35                  40                  45              


Ala Tyr Ile Thr Ser Ser Ser Ile Asn Ile Lys Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Leu Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ile Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Trp Asp Lys Asn Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
        115                 120                 125             


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
    130                 135                 140                 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
145                 150                 155                 160 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
                165                 170                 175     


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
            180                 185                 190         


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
        195                 200                 205             


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220             


<210>  42
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C11 (VH-CL)

<400>  42
gaggtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggcaagag cctgaagctg       60

agctgcgagg ccagcggctt caccttcagc ggctacggca tgcactgggt gagacaggcc      120

cctggcagag gactggaaag cgtggcctac atcaccagca gcagcatcaa cattaagtac      180

gccgacgccg tgaagggccg gttcaccgtg tccagggata acgccaagaa cctgctgttc      240

ctgcagatga acatcctgaa gtccgaggac accgctatgt attactgcgc cagattcgac      300

tgggacaaga actactgggg ccagggcacc atggtcacag tgtctagcgc tagcgtggct      360

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct      420

gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat      480

aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc      540

acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc      600

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg      660

ggagagtgtt ga                                                          672


<210>  43
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-Fc(knob) P329G LALA

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    210                 215                 220                 


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly 
    290                 295                 300                 


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val 
305                 310                 315                 320 


Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
            340                 345                 350         


Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        355                 360                 365             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    370                 375                 380                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
385                 390                 395                 400 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                405                 410                 415     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            420                 425                 430         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        435                 440                 445             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    450                 455                 460                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
465                 470                 475                 480 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                485                 490                 495     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            500                 505                 510         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        515                 520                 525             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    530                 535                 540                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
545                 550                 555                 560 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                565                 570                 575     


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            580                 585                 590         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
        595                 600                 605             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
    610                 615                 620                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
625                 630                 635                 640 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                645                 650                 655     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            660                 665                 670         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        675                 680                 685             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695                 700 


<210>  44
<211>  2103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-Fc(knob) P329G LALA

<400>  44
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagtc cggcaccgcc agcgtcgtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcagcggcgg aggctctgga      660

ggcggctctg aaggcggagg aagtgagggc ggaggctcag aaggcggcgg aagcgaaggt      720

ggcggctctg gcggcggatc cggcgaggtg cagctggtcg agtccggcgg aggcctggtg      780

cagcctggcg gcagcctgag actgagctgc gccgccagcg gctacagctt caccggctac      840

accatgaact gggtccggca ggctcctggc aagggcctcg aatgggtggc cctgatcaac      900

ccctacaagg gcgtgagcac ctacaaccag aagttcaagg accggttcac catcagcgtg      960

gacaagagca agaacaccgc ctatctgcag atgaacagcc tgcgggccga ggacaccgcc     1020

gtgtactact gcgccagaag cggctactac ggcgacagcg actggtactt cgacgtgtgg     1080

ggccagggca cactggtcac cgtgtccagc gctagcacca agggccctag cgtgttccct     1140

ctggccccta gcagcaagag cacaagtgga ggaacagccg ccctgggctg cctggtcaag     1200

gactacttcc ccgagcccgt gaccgtgtcc tggaattctg gcgccctgac aagcggcgtg     1260

cacacatttc cagccgtgct gcagagcagc ggcctgtact ctctgagcag cgtcgtgacc     1320

gtgccctcta gctctctggg cacccagacc tacatctgca acgtgaacca caagcccagc     1380

aacaccaaag tggacaagaa ggtggaaccc aagagctgcg acaagaccca cacctgtccc     1440

ccttgccctg cccctgaagc tgctggtggc ccttccgtgt tcctgttccc cccaaagccc     1500

aaggacaccc tgatgatcag ccggaccccc gaagtgacct gcgtggtggt cgatgtgtcc     1560

cacgaggacc ctgaagtgaa gttcaattgg tacgtggacg gcgtggaagt gcacaatgcc     1620

aagaccaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1680

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1740

ctcggcgccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1800

gtgtacaccc tgcccccatg ccgggatgag ctgaccaaga accaggtcag cctgtggtgc     1860

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1920

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1980

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     2040

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     2100

taa                                                                   2103


<210>  45
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 (VH-CH1)-Fc(hole) P329G LALA

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Lys Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  46
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 (VH-CH1)-Fc(hole) P329G LALA

<400>  46
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggttt cacattcact gactacaaga tacactgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggatat ttcaacccta acagcggtta tagtacctac      180

gcacagaagt tccagggcag ggtcaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagactatcc      300

ccaggcggtt actatgttat ggatgcctgg ggccaaggga ccaccgtgac cgtctcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgcaggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtgcaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctctcgtgc gcagtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcgtg agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa tga                                  1353


<210>  47
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 (VL-CL)

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  48
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 (VL-CL)

<400>  48
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaac aattacttaa attggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctataat accaacaact tgcagacagg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gaagattttg ccacctatta ctgcttgcag cataatagtt ttcccacgtt tggccagggc      300

accaagctcg agatcaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         642


<210>  49
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 (scFab)-Fc(knob) P329G LALA

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Gly 
    210                 215                 220                 


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Gly Gln Val Gln Leu Val Gln Ser Gly Ala 
                245                 250                 255     


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Thr Asp Tyr Lys Ile His Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro Asn Ser Gly Tyr 
    290                 295                 300                 


Ser Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp 
305                 310                 315                 320 


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
                325                 330                 335     


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser Pro Gly Gly Tyr Tyr 
            340                 345                 350         


Val Met Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        355                 360                 365             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    370                 375                 380                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
385                 390                 395                 400 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                405                 410                 415     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            420                 425                 430         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        435                 440                 445             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    450                 455                 460                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
465                 470                 475                 480 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                485                 490                 495     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            500                 505                 510         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        515                 520                 525             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    530                 535                 540                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
545                 550                 555                 560 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                565                 570                 575     


Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            580                 585                 590         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
        595                 600                 605             


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
    610                 615                 620                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
625                 630                 635                 640 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                645                 650                 655     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            660                 665                 670         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        675                 680                 685             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695         


<210>  50
<211>  2094
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 (scFab)-Fc(knob) P329G LALA

<400>  50
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaac aattacttaa attggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctataat accaacaact tgcagacagg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gaagattttg ccacctatta ctgcttgcag cataatagtt ttcccacgtt tggccagggc      300

accaagctcg agatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaaatctgg caccgccagc gtcgtgtgcc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggaa      480

agcgtcaccg agcaggacag caaggactcc acctatagcc tgtccagcac cctgaccctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      600

agcagccccg tgaccaagag cttcaaccgg ggcgagtgca gcggcggagg tagcggaggc      660

ggctctgagg gcggaggaag cgagggcgga ggctccgaag gcggcggaag cgaaggtggc      720

ggctctggcg gcggatccgg ccaggtgcag ctggtgcagt ctggggctga ggtgaagaag      780

cctgggtcct cggtgaaggt ctcctgcaag gcctctggtt tcacattcac tgactacaag      840

atacactggg tgcgacaggc ccctggacaa gggctcgagt ggatgggata tttcaaccct      900

aacagcggtt atagtaccta cgcacagaag ttccagggca gggtcaccat taccgcggac      960

aaatccacga gcacagccta catggagctg agcagcctga gatctgagga cacggccgtg     1020

tattactgtg cgagactatc cccaggcggt tactatgtta tggatgcctg gggccaaggg     1080

accaccgtga ccgtctcctc agctagcacc aagggcccta gcgtgttccc tctggcccct     1140

agcagcaaga gcacaagtgg aggaacagcc gccctgggct gcctggtcaa ggactacttc     1200

cccgagcccg tgaccgtgtc ctggaattct ggcgccctga caagcggcgt gcacacattt     1260

ccagccgtgc tgcagagcag cggcctgtac tctctgagca gcgtcgtgac cgtgccctct     1320

agctctctgg gcacccagac ctacatctgc aacgtgaacc acaagcccag caacaccaaa     1380

gtggacaaga aggtggaacc caagagctgc gacaagaccc acacctgtcc cccttgccct     1440

gcccctgaag ctgctggtgg cccttccgtg ttcctgttcc ccccaaagcc caaggacacc     1500

ctgatgatca gccggacccc cgaagtgacc tgcgtggtgg tcgatgtgtc ccacgaggac     1560

cctgaagtga agttcaattg gtacgtggac ggcgtggaag tgcacaatgc caagaccaag     1620

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1680

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcggcgcc     1740

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1800

ctgcccccat gccgggatga gctgaccaag aaccaggtca gcctgtggtg cctggtcaaa     1860

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1920

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1980

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     2040

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa ataa           2094


<210>  51
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (VH-CH1)-Fc(hole) P329G LALA

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  52
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (VH-CH1)-Fc(hole) P329G LALA

<400>  52
gaggtgcagc tggtcgagag cggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggcta cagcttcacc ggctacacca tgaactgggt ccggcaggca      120

cctggcaagg gactggaatg ggtggccctg atcaacccct acaagggcgt gagcacctac      180

aaccagaagt tcaaggaccg gttcaccatc agcgtggaca agagcaagaa caccgcctat      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaagcggc      300

tactacggcg acagcgactg gtacttcgac gtgtggggcc agggcaccct cgtgaccgtg      360

tctagcgcta gcaccaaggg cccctccgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgctct gggctgcctg gtcaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag      540

agttctggcc tgtatagcct gagcagcgtg gtcaccgtgc cttctagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gagcccaaga gctgcgacaa aactcacaca tgcccaccgt gcccagcacc tgaagctgca      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcg gcgcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt gcaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctc tcgtgcgcag tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctcgtgagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1359


<210>  53
<211>  934
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-GA201 (VH-CH1)-Fc(knob) P329G LALA

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    210                 215                 220                 


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly 
    290                 295                 300                 


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val 
305                 310                 315                 320 


Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
            340                 345                 350         


Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        355                 360                 365             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    370                 375                 380                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
385                 390                 395                 400 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                405                 410                 415     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            420                 425                 430         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        435                 440                 445             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    450                 455                 460                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
                485                 490                 495     


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr 
            500                 505                 510         


Phe Thr Asp Tyr Lys Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly 
        515                 520                 525             


Leu Glu Trp Met Gly Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr 
    530                 535                 540                 


Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
545                 550                 555                 560 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
                565                 570                 575     


Val Tyr Tyr Cys Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp 
            580                 585                 590         


Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        595                 600                 605             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    610                 615                 620                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
625                 630                 635                 640 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                645                 650                 655     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            660                 665                 670         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        675                 680                 685             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    690                 695                 700                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
705                 710                 715                 720 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                725                 730                 735     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            740                 745                 750         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        755                 760                 765             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    770                 775                 780                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
785                 790                 795                 800 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
                805                 810                 815     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            820                 825                 830         


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
        835                 840                 845             


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    850                 855                 860                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
865                 870                 875                 880 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                885                 890                 895     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            900                 905                 910         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        915                 920                 925             


Ser Leu Ser Pro Gly Lys 
    930                 


<210>  54
<211>  2805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-GA201 (VH-CH1)-Fc(knob) P329G LALA

<400>  54
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagtc cggcaccgcc agcgtcgtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcagcggcgg aggctctgga      660

ggcggctctg aaggcggagg aagtgagggc ggaggctcag aaggcggcgg aagcgaaggt      720

ggcggctctg gcggcggatc cggcgaggtg cagctggtcg agtccggcgg aggcctggtg      780

cagcctggcg gcagcctgag actgagctgc gccgccagcg gctacagctt caccggctac      840

accatgaact gggtccggca ggctcctggc aagggcctcg aatgggtggc cctgatcaac      900

ccctacaagg gcgtgagcac ctacaaccag aagttcaagg accggttcac catcagcgtg      960

gacaagagca agaacaccgc ctatctgcag atgaacagcc tgcgggccga ggacaccgcc     1020

gtgtactact gcgccagaag cggctactac ggcgacagcg actggtactt cgacgtgtgg     1080

ggccagggca cactggtcac cgtgtccagc gctagcacca agggcccctc cgtgttcccc     1140

ctggccccca gcagcaagag caccagcggc ggcacagccg ccctcggctg cctggtcaag     1200

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gagccctgac ctccggcgtg     1260

cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgtccag cgtggtcacc     1320

gtgccctcca gcagcctggg cacccagacc tacatctgca acgtgaacca caagcccagc     1380

aataccaagg tggacaagaa ggtggagccc aagagctgcg acggcggtgg tggctccgga     1440

ggcggtggat ctcaggtgca gctggtgcag tctggggctg aggtgaagaa gcctgggtcc     1500

tcggtgaagg tctcctgcaa ggcctctggt ttcacattca ctgactacaa gatacactgg     1560

gtgcgacagg cccctggaca agggctcgag tggatgggat atttcaaccc taacagcggt     1620

tatagtacct acgcacagaa gttccagggc agggtcacca ttaccgcgga caaatccacg     1680

agcacagcct acatggagct gagcagcctg agatctgagg acacggccgt gtattactgt     1740

gcgagactat ccccaggcgg ttactatgtt atggatgcct ggggccaagg gaccaccgtg     1800

accgtctcct cagctagcac caagggcccc tccgtgttcc ccctggcccc cagcagcaag     1860

agcaccagcg gcggcacagc cgctctgggc tgcctggtca aggactactt ccccgagccc     1920

gtgaccgtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg     1980

ctgcagagtt ctggcctgta tagcctgagc agcgtggtca ccgtgccttc tagcagcctg     2040

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag     2100

aaggtggagc ccaagagctg cgacaaaact cacacatgcc caccgtgccc agcacctgaa     2160

gctgcagggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     2220

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     2280

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     2340

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     2400

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcggcgc ccccatcgag     2460

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     2520

tgccgggatg agctgaccaa gaaccaggtc agcctgtggt gcctggtcaa aggcttctat     2580

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     2640

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     2700

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     2760

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     2805


<210>  55
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 (scFab)-Fc(knob) P329G LALA

<400>  55

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu Leu Glu Ser Gly Gly 
                245                 250                 255     


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser 
    290                 295                 300                 


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
305                 310                 315                 320 


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
                325                 330                 335     


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp Phe Gly Gly Phe Asn 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        355                 360                 365             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    370                 375                 380                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
385                 390                 395                 400 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                405                 410                 415     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            420                 425                 430         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        435                 440                 445             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    450                 455                 460                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
465                 470                 475                 480 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                485                 490                 495     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            500                 505                 510         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        515                 520                 525             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    530                 535                 540                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
545                 550                 555                 560 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
                565                 570                 575     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            580                 585                 590         


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
        595                 600                 605             


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    610                 615                 620                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
625                 630                 635                 640 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                645                 650                 655     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            660                 665                 670         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        675                 680                 685             


Ser Leu Ser Pro Gly Lys 
    690                 


<210>  56
<211>  2085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 (scFab)-Fc(knob) P329G LALA

<400>  56
gagatcgtgc tgacacagag ccccggaacc ctgtctctga gccctggcga aagagccacc       60

ctgagctgta gagccagcca gagcgtgacc agcagctacc tggcctggta tcagcagaag      120

cctggacagg cccccagact gctgatcaat gtgggcagca gacgggccac cggcatccct      180

gatagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagactggaa      240

cccgaggact tcgccgtgta ctactgccag cagggcatca tgctgccccc tacatttggc      300

cagggcacca aggtggaaat caagcgtacg gtggccgctc ccagcgtgtt catcttccca      360

cctagcgacg agcagctgaa gtctggcaca gccagcgtcg tgtgcctgct gaacaacttc      420

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      480

caggaaagcg tcaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg      540

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacccaccag      600

ggcctgtcta gccccgtgac caagagcttc aaccggggag aatgtggcgg cggaggatct      660

ggtggcggag gtagtggtgg tggtggatct ggcggaggcg gatccggcgg aggtggaagc      720

ggaggtggtg gaagtggggg agaagtgcag ctgctggaaa gtggcggagg cctggtgcag      780

cctggcggat ctctgagact gagctgtgcc gccagcggct tcacctttag cagctacgcc      840

atgagctggg tccgacaggc ccctggaaag ggactggaat gggtgtccgc catctctggc      900

tctggcggca gcacctacta cgccgatagc gtgaagggcc ggttcaccat cagccgggac      960

aacagcaaga acaccctgta cctgcagatg aacagcctgc gggccgagga taccgccgtg     1020

tattattgcg ccaagggatg gttcggcggc ttcaactatt ggggccaggg aaccctggtc     1080

accgtgtcta gtgctagcac caagggccct agcgtgttcc ctctggcccc tagcagcaag     1140

agcacaagtg gaggaacagc cgccctgggc tgcctggtca aggactactt ccccgagccc     1200

gtgaccgtgt cctggaattc tggcgccctg acaagcggcg tgcacacatt tccagccgtg     1260

ctgcagagca gcggcctgta ctctctgagc agcgtcgtga ccgtgccctc tagctctctg     1320

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa agtggacaag     1380

aaggtggaac ccaagagctg cgacaagacc cacacctgtc ccccttgccc tgcccctgaa     1440

gctgctggtg gcccttccgt gttcctgttc cccccaaagc ccaaggacac cctgatgatc     1500

agccggaccc ccgaagtgac ctgcgtggtg gtcgatgtgt cccacgagga ccctgaagtg     1560

aagttcaatt ggtacgtgga cggcgtggaa gtgcacaatg ccaagaccaa gccgcgggag     1620

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1680

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcggcgc ccccatcgag     1740

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1800

tgccgggatg agctgaccaa gaaccaggtc agcctgtggt gcctggtcaa aggcttctat     1860

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1920

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1980

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     2040

aaccactaca cgcagaagag cctctccctg tctccgggta aataa                     2085


<210>  57
<211>  931
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-3F2 (VH-CH1)-Fc(knob) P329G LALA

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    210                 215                 220                 


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly 
    290                 295                 300                 


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val 
305                 310                 315                 320 


Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
            340                 345                 350         


Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        355                 360                 365             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    370                 375                 380                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
385                 390                 395                 400 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                405                 410                 415     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            420                 425                 430         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        435                 440                 445             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    450                 455                 460                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
                485                 490                 495     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            500                 505                 510         


Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        515                 520                 525             


Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr 
    530                 535                 540                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
545                 550                 555                 560 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                565                 570                 575     


Val Tyr Tyr Cys Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly 
            580                 585                 590         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        595                 600                 605             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    610                 615                 620                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
625                 630                 635                 640 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                645                 650                 655     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            660                 665                 670         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        675                 680                 685             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    690                 695                 700                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
705                 710                 715                 720 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                725                 730                 735     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            740                 745                 750         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        755                 760                 765             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    770                 775                 780                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
785                 790                 795                 800 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                805                 810                 815     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            820                 825                 830         


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        835                 840                 845             


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    850                 855                 860                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
865                 870                 875                 880 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                885                 890                 895     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            900                 905                 910         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        915                 920                 925             


Pro Gly Lys 
    930     


<210>  58
<211>  2796
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 (scFab)-3F2 (VH-CH1)-Fc(knob) P329G LALA

<400>  58
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagtc cggcaccgcc agcgtcgtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gcagcggcgg aggctctgga      660

ggcggctctg aaggcggagg aagtgagggc ggaggctcag aaggcggcgg aagcgaaggt      720

ggcggctctg gcggcggatc cggcgaggtg cagctggtcg agtccggcgg aggcctggtg      780

cagcctggcg gcagcctgag actgagctgc gccgccagcg gctacagctt caccggctac      840

accatgaact gggtccggca ggctcctggc aagggcctcg aatgggtggc cctgatcaac      900

ccctacaagg gcgtgagcac ctacaaccag aagttcaagg accggttcac catcagcgtg      960

gacaagagca agaacaccgc ctatctgcag atgaacagcc tgcgggccga ggacaccgcc     1020

gtgtactact gcgccagaag cggctactac ggcgacagcg actggtactt cgacgtgtgg     1080

ggccagggca cactggtcac cgtgtccagc gctagcacca agggcccctc cgtgttcccc     1140

ctggccccca gcagcaagag caccagcggc ggcacagccg ccctcggctg cctggtcaag     1200

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gagccctgac ctccggcgtg     1260

cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgtccag cgtggtcacc     1320

gtgccctcca gcagcctggg cacccagacc tacatctgca acgtgaacca caagcccagc     1380

aataccaagg tggacaagaa ggtggagccc aagagctgcg acggcggtgg tggctccgga     1440

ggaggaggca gcgaggtgca gctgctggaa tctggaggcg gcctggtgca gcctggcggc     1500

agcctgagac tgtcttgcgc cgccagcggc ttcaccttca gcagctacgc catgagctgg     1560

gtccgacagg ctcctggcaa gggactggaa tgggtgtccg ccatctccgg cagcggaggc     1620

agcacctact acgccgacag cgtgaagggc cggttcacca tcagcagaga caacagcaag     1680

aacaccctgt acctgcagat gaacagcctg cgggccgagg ataccgccgt gtattattgc     1740

gccaagggat ggttcggcgg cttcaactac tggggccagg gaaccctggt gacagtgtcc     1800

agcgccagca ccaagggccc ctccgtgttt cctctggccc ccagcagcaa gagcacctct     1860

ggcggaacag ccgccctggg ctgcctggtg aaagactact tccccgagcc cgtgaccgtg     1920

tcctggaact ctggcgccct gaccagcggc gtgcacacct ttccagccgt gctgcagagc     1980

agcggcctgt actccctgag cagcgtggtg acagtgccct ccagcagcct gggcacccag     2040

acctacatct gcaacgtgaa ccacaagccc agcaacacca aagtggacaa gaaggtggaa     2100

cccaagagct gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga agctgcaggg     2160

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     2220

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     2280

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     2340

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     2400

aaggagtaca agtgcaaggt ctccaacaaa gccctcggcg cccccatcga gaaaaccatc     2460

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atgccgggat     2520

gagctgacca agaaccaggt cagcctgtgg tgcctggtca aaggcttcta tcccagcgac     2580

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     2640

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     2700

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     2760

acgcagaaga gcctctccct gtctccgggt aaatga                               2796


<210>  59
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 (VH-CH1)-Fc(hole) P329G LALA

<400>  59

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  60
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 (VH-CH1)-Fc(hole) P329G LALA

<400>  60
gaggtgcagc tgctggaatc tggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaagg gactggaatg ggtgtccgcc atctccggca gcggaggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agcagagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgccgtgt attattgcgc caagggatgg      300

ttcggcggct tcaactactg gggccaggga accctggtga cagtgtccag cgccagcacc      360

aagggcccct ccgtgtttcc tctggccccc agcagcaaga gcacctctgg cggaacagcc      420

gccctgggct gcctggtgaa agactacttc cccgagcccg tgaccgtgtc ctggaactct      480

ggcgccctga ccagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

tccctgagca gcgtggtgac agtgccctcc agcagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaaa gtggacaaga aggtggaacc caagagctgc      660

gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa atga                                            1344


<210>  61
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 (VL-CL)

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  62
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 (VL-CL)

<400>  62
gagatcgtgc tgacccagtc tcccggcacc ctgagcctga gccctggcga gagagccacc       60

ctgagctgca gagccagcca gagcgtgacc agcagctacc tggcctggta tcagcagaag      120

cccggccagg cccccagact gctgatcaac gtgggcagca gacgggccac cggcatcccc      180

gatagattca gcggcagcgg ctccggcacc gacttcaccc tgaccatcag ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagggcatca tgctgccccc caccttcggc      300

cagggcacca aggtggaaat caagcggacc gtggccgctc ccagcgtgtt catcttccca      360

cccagcgacg agcagctgaa gtccggcaca gccagcgtgg tgtgcctgct gaacaacttc      420

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      480

caggaatccg tgaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg      540

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacccaccag      600

ggcctgtcca gccccgtgac caagagcttc aaccggggcg agtgctga                   648


<210>  63
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A (VH-CH1)- V9 (VL-CH1)-Fc(knob) P329G LALA

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
225                 230                 235                 240 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                245                 250                 255     


Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln 
            260                 265                 270         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu 
        275                 280                 285             


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    290                 295                 300                 


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
305                 310                 315                 320 


Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr 
                325                 330                 335     


Lys Val Glu Ile Lys Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
            340                 345                 350         


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
        355                 360                 365             


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
    370                 375                 380                 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
385                 390                 395                 400 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
                405                 410                 415     


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
            420                 425                 430         


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
        435                 440                 445             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
    450                 455                 460                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
465                 470                 475                 480 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                485                 490                 495     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            500                 505                 510         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        515                 520                 525             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    530                 535                 540                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
545                 550                 555                 560 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                565                 570                 575     


Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
            580                 585                 590         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        595                 600                 605             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    610                 615                 620                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
625                 630                 635                 640 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                645                 650                 655     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            660                 665                 670         


Lys 
    


<210>  64
<211>  2022
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A (VH-CH1)- V9 (VL-CH1)-Fc(knob) P329G LALA

<400>  64
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggcc      120

cctggacagg gcctggaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accaccgaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctact atgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agtgctagca caaagggccc cagcgtgttc cctctggccc ctagcagcaa gagcacatct      420

ggcggaacag ccgccctggg ctgcctggtc aaggactact ttcccgagcc cgtgacagtg      480

tcctggaact ctggcgccct gacaagcggc gtgcacacct ttccagccgt gctgcagagc      540

agcggcctgt actctctgag cagcgtggtc accgtgccta gctctagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa      660

cccaagagct gcggcggagg cggatccgga ggcggaggat ctgatatcca gatgacccag      720

agccccagca gcctgtctgc cagcgtgggc gacagagtga ccattacctg cagagccagc      780

caggacatca gaaactacct gaactggtat cagcagaagc ccggcaaggc ccccaagctg      840

ctgatctact acaccagcag actggaatcc ggcgtgccca gcagattttc cggcagcggc      900

tctggcaccg actacaccct gacaatcagc agcctgcagc ccgaggactt cgccacctac      960

tactgccagc agggcaacac cctgccctgg acatttggac agggcacaaa ggtggaaatc     1020

aagagcagcg cctccaccaa gggcccttcc gtgtttccac tggcccccag ctctaagagc     1080

accagcggag gaacagctgc tctgggatgt ctcgtgaagg attacttccc cgaacctgtg     1140

accgtcagct ggaacagcgg cgctctgaca tctggggtgc acacattccc cgctgtcctg     1200

cagtcctccg gcctgtacag tctgtccagc gtcgtgacag tgcctagcag ctccctggga     1260

acacagacat atatctgtaa tgtcaatcac aagccctcta ataccaaggt cgacaaaaaa     1320

gtcgagccca agtcctgcga caagacccac acctgtcccc cttgtcctgc ccctgaagct     1380

gctggcggcc cttctgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc     1440

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag     1500

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agacaaagcc gcgggaggag     1560

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1620

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcggcgcccc catcgagaaa     1680

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatgc     1740

cgggatgagc tgaccaagaa ccaggtcagc ctgtggtgcc tggtcaaagg cttctatccc     1800

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1860

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1920

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1980

cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                        2022


<210>  65
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A (VH-CH1)-Fc(hole) P329G LALA

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  66
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A (VH-CH1)-Fc(hole) P329G LALA

<400>  66
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agcgctagca ccaagggccc ctccgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcacag ccgctctggg ctgcctggtc aaggactact tccccgagcc cgtgaccgtg      480

tcctggaaca gcggagccct gacctccggc gtgcacacct tccccgccgt gctgcagagt      540

tctggcctgt atagcctgag cagcgtggtc accgtgcctt ctagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag      660

cccaagagct gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga agctgcaggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcggcg cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtgca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctctcg tgcgcagtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaatga                               1356


<210>  67
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A (VL-CL)

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  68
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A (VL-CL)

<400>  68
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttag                   648


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR1

<400>  69

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn 
1               5                   10      


<210>  70
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR1

<400>  70
ggctactcca tcaccagtgg ttattactgg aac                                    33


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR2

<400>  71

Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  72
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR2

<400>  72
tacataacct acgacggtag caataactac aacccatctc tcaaaaat                    48


<210>  73
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR3

<400>  73

Phe Asp Tyr 
1           


<210>  74
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 HCDR3

<400>  74
tttgactac                                                                9


<210>  75
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 VH

<400>  75

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  76
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 VH

<400>  76
gaggtccagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaagctgga atggatgggc tacataacct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc ggactttgac      300

tactggggcc aaggcaccac tctcacagtc tcctca                                336


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR1

<400>  77

Ser Ala Ser Gln Gly Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  78
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR1

<400>  78
agtgcaagtc agggcattag aaattattta aac                                    33


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR2

<400>  79

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR2

<400>  80
tacacatcaa gtttacactc a                                                 21


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR3

<400>  81

Gln Gln Tyr Ser Lys Leu Pro Trp Thr 
1               5                   


<210>  82
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 LCDR3

<400>  82
cagcagtata gtaagcttcc ttggacg                                           27


<210>  83
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 VL

<400>  83

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  84
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 VL

<400>  84
gatattgtgc tcacacagtc tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattaga aattatttaa actggtatca gcagagacca      120

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR1

<400>  85

Asp Tyr Lys Ile His 
1               5   


<210>  86
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR1

<400>  86
gactacaaga tacac                                                        15


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR2

<400>  87

Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  88
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR2

<400>  88
tatttcaacc ctaacagcgg ttatagtacc tacgcacaga agttccaggg c                51


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR3

<400>  89

Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala 
1               5                   10      


<210>  90
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 HCDR3

<400>  90
ctatccccag gcggttacta tgttatggat gcc                                    33


<210>  91
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 VH

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Lys Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Phe Asn Pro Asn Ser Gly Tyr Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  92
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 VH

<400>  92
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggttt cacattcact gactacaaga tacactgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggatat ttcaacccta acagcggtta tagtacctac      180

gcacagaagt tccagggcag ggtcaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagactatcc      300

ccaggcggtt actatgttat ggatgcctgg ggccaaggga ccaccgtgac cgtctcctca      360


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR1

<400>  93

Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  94
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR1

<400>  94
cgggcaagtc agggcattaa caattactta aat                                    33


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR2

<400>  95

Asn Thr Asn Asn Leu Gln Thr 
1               5           


<210>  96
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR2

<400>  96
aataccaaca acttgcagac a                                                 21


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR3

<400>  97

Leu Gln His Asn Ser Phe Pro Thr 
1               5               


<210>  98
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 LCDR3

<400>  98
ttgcagcata atagttttcc cacg                                              24


<210>  99
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GA201 VL

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  100
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GA201 VL

<400>  100
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaac aattacttaa attggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctataat accaacaact tgcagacagg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gaagattttg ccacctatta ctgcttgcag cataatagtt ttcccacgtt tggccagggc      300

accaagctcg agatcaag                                                    318


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR1

<400>  101

Ser Tyr Ala Met Ser 
1               5   


<210>  102
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR1

<400>  102
agctacgcca tgagc                                                        15


<210>  103
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR2

<400>  103

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  104
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR2

<400>  104
gccatctccg gcagcggagg cagcacctac tacgccgaca gcgtgaag                    48


<210>  105
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR3

<400>  105

Tyr Cys Ala Lys Gly Trp Phe Gly 
1               5               


<210>  106
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 HCDR3

<400>  106
tattgcgcca agggatggtt cggc                                              24


<210>  107
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 VH

<400>  107

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  108
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 VH

<400>  108
gaggtgcagc tgctggaatc tggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaagg gactggaatg ggtgtccgcc atctccggca gcggaggcag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agcagagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgccgtgt attattgcgc caagggatgg      300

ttcggcggct tcaactactg gggccaggga accctggtga cagtgtccag c               351


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR1

<400>  109

Arg Ala Ser Gln Ser Val Thr Ser Ser Tyr Leu 
1               5                   10      


<210>  110
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR1

<400>  110
agagccagcc agagcgtgac cagcagctac ctg                                    33


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR2

<400>  111

Asn Val Gly Ser Arg Arg Ala 
1               5           


<210>  112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR2

<400>  112
aacgtgggca gcagacgggc c                                                 21


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR3

<400>  113

Cys Gln Gln Gly Ile Met Leu Pro Pro 
1               5                   


<210>  114
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 LCDR3

<400>  114
tgccagcagg gcatcatgct gcccccc                                           27


<210>  115
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2 VL

<400>  115

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  116
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2 VL

<400>  116
gagatcgtgc tgacccagtc tcccggcacc ctgagcctga gccctggcga gagagccacc       60

ctgagctgca gagccagcca gagcgtgacc agcagctacc tggcctggta tcagcagaag      120

cccggccagg cccccagact gctgatcaac gtgggcagca gacgggccac cggcatcccc      180

gatagattca gcggcagcgg ctccggcacc gacttcaccc tgaccatcag ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagggcatca tgctgccccc caccttcggc      300

cagggcacca aggtggaaat caag                                             324


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR1

<400>  117

Glu Phe Gly Met Asn 
1               5   


<210>  118
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR1

<400>  118
gagttcggca tgaac                                                        15


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR2

<400>  119

Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR2

<400>  120
tggatcaaca ccaagaccgg cgaggccacc tacgtggaag agttcaaggg c                51


<210>  121
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR3

<400>  121

Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  122
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A HCDR3

<400>  122
tgggacttcg cctattacgt ggaagccatg gactac                                 36


<210>  123
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A VH

<400>  123

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  124
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A VH

<400>  124
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agc                                                                    363


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR1

<400>  125

Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala 
1               5                   10      


<210>  126
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR1

<400>  126
aaggccagtg cggctgtggg tacgtatgtt gcg                                    33


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR2

<400>  127

Ser Ala Ser Tyr Arg Lys Arg 
1               5           


<210>  128
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR2

<400>  128
tcggcatcct accgcaaaag g                                                 21


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR3

<400>  129

His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr 
1               5                   10  


<210>  130
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A LCDR3

<400>  130
caccaatatt acacctatcc tctattcacg                                        30


<210>  131
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A VL

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  132
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A VL

<400>  132
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      120

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      300

cagggcacca agctcgagat caag                                             324


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR1

<400>  133

Gly Tyr Thr Ile Thr Asp Ser Asn Ile His 
1               5                   10  


<210>  134
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR1

<400>  134
ggctacacca tcaccgacag caacatccac                                        30


<210>  135
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR2

<400>  135

Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln 
1               5                   10              


<210>  136
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR2

<400>  136
tacatctacc cctacaacgg cggcaccgac tacaaccag                              39


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR3

<400>  137

Gly Asn Pro Trp Leu Ala Tyr 
1               5           


<210>  138
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 HCDR3

<400>  138
ggcaacccct ggctggccta t                                                 21


<210>  139
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VH

<400>  139

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  140
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VH

<400>  140
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggcagcag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccatcacc gacagcaaca tccactgggt ccgacaggcc      120

cctgggcaga gcctggaatg gatcggctac atctacccct acaacggcgg caccgactac      180

aaccagaagt tcaagaaccg ggccaccctg accgtggaca accccaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccttct actactgcgt gaacggcaac      300

ccctggctgg cctattgggg ccagggaacc ctggtcaccg tgtctagc                   348


<210>  141
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR1

<400>  141

Arg Ala Ser Glu Ser Leu Asp Asn Tyr Gly Ile Arg Phe Leu Thr 
1               5                   10                  15  


<210>  142
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR1

<400>  142
cgggccagcg agagcctgga caactacggc atccggtttc tgacc                       45


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR2

<400>  143

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  144
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR2

<400>  144
gccgccagca accagggcag c                                                 21


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR3

<400>  145

Gln Gln Thr Lys Glu Val Pro Trp Ser 
1               5                   


<210>  146
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 LCDR3

<400>  146
cagcagacca aagaggtgcc ctggtcc                                           27


<210>  147
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VL

<400>  147

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105                 110     


<210>  148
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD33 VL

<400>  148
gacatccagc tgacccagag ccccagcacc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcga gagcctggac aactacggca tccggtttct gacctggttc      120

cagcagaagc ccggcaaggc ccccaagctg ctgatgtacg ccgccagcaa ccagggcagc      180

ggcgtgccaa gcagattcag cggcagcggc tccggcaccg agttcaccct gaccatcagc      240

agcctgcagc ccgacgactt cgccacctac tactgccagc agaccaaaga ggtgccctgg      300

tccttcggcc agggcaccaa ggtggaagtg aag                                   333


<210>  149
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  149

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  150
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  150

Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  151
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  151

Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  152
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  152

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


<210>  153
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  153

Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Ser Gly 
        


<210>  154
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader 1

<400>  154

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  155
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 1

<400>  155
atggactgga cctggagaat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  156
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 1

<400>  156
atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  157
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader 2

<400>  157

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys 
            20          


<210>  158
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 2

<400>  158
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc       60

aggtgt                                                                  66


<210>  159
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader 3

<400>  159

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  160
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 3

<400>  160
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcc          57


<210>  161
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 3

<400>  161
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccactggagt gcattcc          57


<210>  162
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader 3

<400>  162
atgggctggt cctgcatcat cctgtttctg gtcgccacag ccaccggcgt gcactct          57


<210>  163
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 HCDR1

<400>  163

Gly Tyr Thr Met Asn 
1               5   


<210>  164
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 HCDR1

<400>  164
ggctacacca tgaac                                                        15


<210>  165
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 HCDR2

<400>  165

Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  166
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 HCDR2

<400>  166
ctgatcaacc cctacaaggg cgtgagcacc tacaaccaga agttcaagga c                51


<210>  167
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 HCDR3

<400>  167

Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val 
1               5                   10              


<210>  168
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 HCDR3

<400>  168
agcggctact acggcgacag cgactggtac ttcgacgtg                              39


<210>  169
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 VH

<400>  169

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  170
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 VH

<400>  170
gaggtgcagc tggtcgagtc cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggcta cagcttcacc ggctacacca tgaactgggt ccggcaggct      120

cctggcaagg gcctcgaatg ggtggccctg atcaacccct acaagggcgt gagcacctac      180

aaccagaagt tcaaggaccg gttcaccatc agcgtggaca agagcaagaa caccgcctat      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaagcggc      300

tactacggcg acagcgactg gtacttcgac gtgtggggcc agggcacact ggtcaccgtg      360

tccagc                                                                 366


<210>  171
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 LCDR1

<400>  171

Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  172
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 LCDR1

<400>  172
cgggccagcc aggacatcag aaactacctg aac                                    33


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 LCDR2

<400>  173

Tyr Thr Ser Arg Leu Glu Ser 
1               5           


<210>  174
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 LCDR2

<400>  174
tacacctcta gactggaaag c                                                 21


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 LCDR3

<400>  175

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  176
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 LCDR3

<400>  176
cagcagggca acacactccc ctggacc                                           27


<210>  177
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9 VL

<400>  177

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  178
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9 VL

<400>  178
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctctagac tggaaagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcaacacac tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa g                                                321


<210>  179
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9(VH-CL)-LC007(VL-CL)

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
                245                 250                 255     


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            260                 265                 270         


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        275                 280                 285             


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    290                 295                 300                 


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
305                 310                 315                 320 


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                325                 330                 335     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            340                 345                 350         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        355                 360                 365             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    370                 375                 380                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
385                 390                 395                 400 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                405                 410                 415     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            420                 425                 430         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        435                 440                 445             


Phe Asn Arg Gly Glu Cys 
    450                 


<210>  180
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9(VH-CL)-LC007(VL-CL)

<400>  180
gaggtgcagc tggtggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggcta cagcttcacc ggctacacca tgaactgggt gcgccaggcc      120

cctggcaagg gactggaatg ggtggccctg atcaacccct acaagggcgt gtccacctac      180

aaccagaagt tcaaggaccg gttcaccatc agcgtggaca agagcaagaa caccgcctac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actattgtgc cagaagcggc      300

tactacggcg acagcgactg gtacttcgac gtgtggggcc agggcacact cgtgaccgtg      360

tcaagcgcta gcgtggccgc tcccagcgtg ttcatcttcc cacctagcga cgagcagctg      420

aagtccggca cagcctctgt cgtgtgcctg ctgaacaact tctacccccg cgaggccaag      480

gtgcagtgga aggtggacaa tgccctgcag agcggcaaca gccaggaaag cgtgaccgag      540

caggacagca aggatagcac ctacagcctg agcagcaccc tgaccctgag caaggccgac      600

tacgagaagc acaaggtgta cgcctgcgaa gtgacccacc agggcctgtc tagccccgtg      660

accaagagct tcaaccgggg cgagtgtgat ggcggaggcg gatccggggg aggcggctct      720

gatattgtgc tgacccagag ccccagcagc ctgtctgcct ctctgggcga cagagtgacc      780

atcagctgta gcgcctctca gggcatccgg aactacctga actggtatca gcagcggccc      840

gacggcaccg tgaagctgct gatctactac accagctccc tgcactccgg cgtgcccagc      900

agattttctg gcagcggctc cggcaccgac tactccctga ccatctccaa cctggaaccc      960

gaggatatcg ccacctacta ctgccagcag tactccaagc tgccctggac ctttggaggc     1020

ggcaccaagc tggaaatcaa gcgtacggtg gctgccccct ccgtgtttat ctttccccca     1080

tccgatgaac agctgaaaag cggcaccgcc agcgtcgtgt gtctgctgaa caatttttac     1140

cctagggaag ctaaagtgca gtggaaagtg gataacgcac tgcagtccgg caactcccag     1200

gaatctgtga cagaacagga ctctaaggac agcacatact ccctgtcctc caccctgaca     1260

ctgtctaagg ctgattatga gaaacacaaa gtgtatgctt gtgaagtgac acatcaggga     1320

ctgagcagcc ctgtgacaaa gtccttcaac agaggcgagt gc                        1362


<210>  181
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(knob) P329G LALA

<400>  181

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  182
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(knob) P329G LALA

<400>  182
gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gccgggatga gctgaccaag      420

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  183
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9(VL-CH1)

<400>  183

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys 
    210         


<210>  184
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9(VL-CH1)

<400>  184
gatattcaga tgacccagag ccccagctct ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagac tggaaagcgg cgtgccctcc      180

agattttccg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggatttcg ccacatatta ctgccagcag ggcaataccc tgccctggac cttcggacag      300

ggcacaaaag tggaaatcaa gagcagcgct tccaccaaag gcccttccgt gtttcctctg      360

gctcctagct ccaagtccac ctctggaggc accgctgctc tcggatgcct cgtgaaggat      420

tattttcctg agcctgtgac agtgtcctgg aatagcggag cactgacctc tggagtgcat      480

actttccccg ctgtgctgca gtcctctgga ctgtacagcc tgagcagcgt ggtgacagtg      540

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaac      600

accaaggtgg acaagaaggt ggaacccaag tcttgt                                636


<210>  185
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9(VH-CL)-Fc(knob) P329G LALA

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  186
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9(VH-CL)-Fc(knob) P329G LALA

<400>  186
gaggtgcagc tggtcgagag cggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggcta cagcttcacc ggctacacca tgaactgggt ccggcaggca      120

cctggcaagg gactggaatg ggtggccctg atcaacccct acaagggcgt gagcacctac      180

aaccagaagt tcaaggaccg gttcaccatc agcgtggaca agagcaagaa caccgcctat      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaagcggc      300

tactacggcg acagcgactg gtacttcgac gtgtggggcc agggcaccct cgtgaccgtg      360

tctagcgcta gcgtggccgc tccctccgtg tttatctttc ccccatccga tgaacagctg      420

aaaagcggca ccgcctccgt cgtgtgtctg ctgaacaatt tttaccctag ggaagctaaa      480

gtgcagtgga aagtggataa cgcactgcag tccggcaact cccaggaatc tgtgacagaa      540

caggactcca aggacagcac ctactccctg tcctccaccc tgacactgtc taaggctgat      600

tatgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc      660

acaaagagct tcaacagggg agagtgtgac aagacccaca cctgtccccc ttgtcctgcc      720

cctgaagctg ctggcggccc ttctgtgttc ctgttccccc caaagcccaa ggacaccctg      780

atgatcagcc ggacccccga agtgacctgc gtggtggtgg atgtgtccca cgaggaccct      840

gaagtgaagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cggcgccccc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatgcc gggatgagct gaccaagaac caggtcagcc tgtggtgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1368


<210>  187
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007(VH-CH1)-V9(VH-CL)-Fc(knob) P329G LALA

<400>  187

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
225                 230                 235                 240 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr 
                245                 250                 255     


Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            260                 265                 270         


Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln 
        275                 280                 285             


Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr 
    290                 295                 300                 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
305                 310                 315                 320 


Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp 
                325                 330                 335     


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    450                 455                 460                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
465                 470                 475                 480 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                485                 490                 495     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            500                 505                 510         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        515                 520                 525             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    530                 535                 540                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
545                 550                 555                 560 


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                565                 570                 575     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu 
            580                 585                 590         


Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
        595                 600                 605             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    610                 615                 620                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
625                 630                 635                 640 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                645                 650                 655     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            660                 665                 670         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        675                 680         


<210>  188
<211>  2046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007(VH-CH1)- V9(VH-CL)-Fc(knob) P329G LALA

<400>  188
gaggtgcagc tgcaggaatc tggccctggc ctggtcaagc caagccagag tctgagcctg       60

acctgcagcg tgaccggcta cagcattacc agcggctact actggaactg gattcggcag      120

ttccccggca ataagctgga atggatgggc tacatcacct acgacggcag caacaactac      180

aaccccagcc tgaagaaccg gatcagcatc acccgggaca ccagcaagaa ccagttcttc      240

ctgaagctga acagcgtgac caccgaggac accgccacat actattgcgc cgacttcgac      300

tactggggcc agggcaccac cctgaccgtg tccagcgcca gcacaaaggg ccctagcgtg      360

ttccctctgg cccccagcag caagagcaca agcggcggaa cagccgccct gggctgcctc      420

gtgaaggact acttccccga gcccgtgaca gtgtcttgga acagcggagc cctgacaagc      480

ggcgtgcaca ccttccctgc cgtgctgcag agcagcggcc tgtactccct gagcagcgtg      540

gtcaccgtgc ctagcagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      600

cccagcaaca ccaaagtgga caagaaggtg gagcccaaga gctgtgatgg cggaggaggg      660

tccggaggcg gaggatccga agtgcagctg gtggaatctg gcggaggcct ggtgcagcct      720

ggcggatctc tgagactgag ctgtgccgcc agcggctaca gcttcaccgg ctacaccatg      780

aactgggtgc gccaggcccc tggcaaggga ctggaatggg tggccctgat caacccctac      840

aagggcgtgt ccacatacaa ccagaagttc aaggaccggt tcaccatcag cgtggacaag      900

agcaagaaca ccgcctacct gcagatgaac agcctgcggg ccgaggacac cgccgtgtac      960

tattgtgcca gaagcggcta ctacggcgac agcgactggt acttcgacgt gtggggccag     1020

ggcacactcg tgaccgtgtc aagcgctagc gtggccgctc cctccgtgtt tatctttccc     1080

ccatccgatg aacagctgaa aagcggcacc gcctccgtcg tgtgtctgct gaacaatttt     1140

taccctaggg aagctaaagt gcagtggaaa gtggataacg cactgcagtc cggcaactcc     1200

caggaatctg tgacagaaca ggactccaag gacagcacct actccctgtc ctccaccctg     1260

acactgtcta aggctgatta tgagaaacac aaagtctacg cctgcgaagt cacccatcag     1320

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtgacaa gacccacacc     1380

tgtccccctt gtcctgcccc tgaagctgct ggcggccctt ctgtgttcct gttcccccca     1440

aagcccaagg acaccctgat gatcagccgg acccccgaag tgacctgcgt ggtggtggat     1500

gtgtcccacg aggaccctga agtgaagttc aattggtacg tggacggcgt ggaagtgcac     1560

aacgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1620

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1680

aaagccctcg gcgcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1740

ccacaggtgt acaccctgcc cccatgccgg gatgagctga ccaagaacca ggtcagcctg     1800

tggtgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1860

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1920

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1980

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2040

ggtaaa                                                                2046


<210>  189
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2(VL-CL)

<400>  189

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  190
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2(VL-CL)

<400>  190
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgcc gggccagcca gggcatccgg aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagcc tgcacagcgg cgtgcctagc      180

cggtttagcg gcagcggctc cggcaccgac ttcaccctga ccattagctc cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacagcaagc tgccctggac cttcggccag      300

ggaacaaagg tggagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  191
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9(VL-CH1)-M4-3 ML2(VH-CH1)-Fc(knob) P329G LALA

<400>  191

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    210                 215                 220                 


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
225                 230                 235                 240 


Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly Tyr Tyr 
                245                 250                 255     


Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            260                 265                 270         


Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Ser 
        275                 280                 285             


Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
    290                 295                 300                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Asp 
305                 310                 315                 320 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                325                 330                 335     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            340                 345                 350         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        355                 360                 365             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    370                 375                 380                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
385                 390                 395                 400 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                405                 410                 415     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            420                 425                 430         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        435                 440                 445             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    450                 455                 460                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
465                 470                 475                 480 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                485                 490                 495     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            500                 505                 510         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        515                 520                 525             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    530                 535                 540                 


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
545                 550                 555                 560 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
                565                 570                 575     


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            580                 585                 590         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        595                 600                 605             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    610                 615                 620                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
625                 630                 635                 640 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                645                 650                 655     


Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 


<210>  192
<211>  1992
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9(VL-CH1)-M4-3 ML2(VH-CH1)-Fc(knob) P329G LALA (DNA)

<400>  192
gatatccaga tgacccagag ccccagctct ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagac tggaaagcgg cgtgccctcc      180

agattttccg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggatttcg ccacatatta ctgccagcag ggcaataccc tgccctggac cttcggacag      300

ggcacaaaag tggaaatcaa gagcagcgct tccaccaaag gcccttccgt gtttcctctg      360

gctcctagct ccaagtccac ctctggaggc accgctgctc tcggatgcct cgtgaaggat      420

tattttcctg agcctgtgac agtgtcctgg aatagcggag cactgacctc tggagtgcat      480

actttccccg ctgtgctgca gtcctctgga ctgtacagcc tgagcagcgt ggtgacagtg      540

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaac      600

accaaggtgg acaagaaggt ggaacccaag tcttgtggcg gaggcggatc cggcggaggg      660

ggatctcagg tgcagctgca ggaaagcggc cctggcctgg tcaagcccag ccagaccctg      720

agcctgacct gcaccgtgtc cggcggcagc atcaccagcg gctactactg gaactggatt      780

cggcagcacc ccggcaaggg cctggaatgg atcggctaca tcacctacga cggcagcaac      840

aactacaacc ccagcctgaa gtccagagtg accatcagcc gggacaccag caagaaccag      900

ttcagcctga agctgtccag cgtgacagcc gccgacaccg ccgtgtacta ctgcgccgac      960

ttcgactact ggggccaggg caccctggtc accgtgtcca gcgctagcac caagggcccc     1020

agcgtgttcc ccctggcacc cagcagcaag agcacatctg gcggaacagc cgctctgggc     1080

tgtctggtga aagactactt ccccgagccc gtgaccgtgt cttggaactc tggcgccctg     1140

accagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctccctgtcc     1200

tccgtggtca ccgtgccctc tagctccctg ggaacacaga catatatctg taatgtcaat     1260

cacaagcctt ccaacaccaa agtcgataag aaagtcgagc ccaagagctg cgacaaaact     1320

cacacatgcc caccgtgccc agcacctgaa gctgcagggg gaccgtcagt cttcctcttc     1380

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     1440

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1500

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1560

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1620

tccaacaaag ccctcggcgc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1680

cgagaaccac aggtgtacac cctgccccca tgccgggatg agctgaccaa gaaccaggtc     1740

agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1800

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1860

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1920

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1980

tctccgggta aa                                                         1992


<210>  193
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2(VH-CH1)-Fc(hole) P329G LALA

<400>  193

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  194
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2(VH-CH1)-Fc(hole) P329G LALA

<400>  194
caggtgcagc tgcaggaaag cggccctggc ctggtcaagc ccagccagac cctgagcctg       60

acctgcaccg tgtccggcgg cagcatcacc agcggctact actggaactg gatccggcag      120

caccccggca agggcctgga atggatcggc tacatcacct acgacggcag caacaactac      180

aaccccagcc tgaagtccag agtgaccatc agccgggaca ccagcaagaa ccagttcagc      240

ctgaagctgt ccagcgtgac agccgccgac accgccgtgt actactgcgc cgacttcgac      300

tactggggcc agggcaccct ggtcaccgtg tccagcgcta gcaccaaggg cccctccgtg      360

ttccccctgg cccccagcag caagagcacc agcggcggca cagccgctct gggctgcctg      420

gtcaaggact acttccccga gcccgtgacc gtgtcctgga acagcggagc cctgacctcc      480

ggcgtgcaca ccttccccgc cgtgctgcag agttctggcc tgtatagcct gagcagcgtg      540

gtcaccgtgc cttctagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      600

cccagcaaca ccaaggtgga caagaaggtg gagcccaaga gctgcgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaagctgca gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcg gcgcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt gcaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctc     1080

tcgtgcgcag tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctcgtgagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaa                                                                1326


<210>  195
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9(VH-CL)-M4-3 ML2(VH-CH1)-Fc(knob) P329G LALA

<400>  195

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
225                 230                 235                 240 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr 
                245                 250                 255     


Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly Tyr 
            260                 265                 270         


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
        275                 280                 285             


Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys 
    290                 295                 300                 


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
305                 310                 315                 320 


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                325                 330                 335     


Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            340                 345                 350         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        355                 360                 365             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    370                 375                 380                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
385                 390                 395                 400 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                405                 410                 415     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            420                 425                 430         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        435                 440                 445             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    450                 455                 460                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
465                 470                 475                 480 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                485                 490                 495     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            500                 505                 510         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        515                 520                 525             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    530                 535                 540                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
545                 550                 555                 560 


Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                565                 570                 575     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
            580                 585                 590         


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
        595                 600                 605             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    610                 615                 620                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
625                 630                 635                 640 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                645                 650                 655     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            660                 665                 670         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        675                 680     


<210>  196
<211>  2043
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9(VH-CL)-M4-3 ML2(VH-CH1)-Fc(knob) P329G LALA (DNA)

<400>  196
gaggtgcagc tggtcgagag cggaggcggc ctggtgcagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggcta cagcttcacc ggctacacca tgaactgggt ccggcaggca      120

cctggcaagg gactggaatg ggtggccctg atcaacccct acaagggcgt gagcacctac      180

aaccagaagt tcaaggaccg gttcaccatc agcgtggaca agagcaagaa caccgcctat      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaagcggc      300

tactacggcg acagcgactg gtacttcgac gtgtggggcc agggcaccct cgtgaccgtg      360

tctagcgcta gcgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      420

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa      480

gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag      540

caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac      600

tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc      660

acaaagagct tcaacagggg agagtgtggc ggaggcggat ccggcggagg gggatctcag      720

gtgcagctgc aggaaagcgg ccctggcctg gtcaagccca gccagaccct gagcctgacc      780

tgcaccgtgt ccggcggcag catcaccagc ggctactact ggaactggat tcggcagcac      840

cccggcaagg gcctggaatg gatcggctac atcacctacg acggcagcaa caactacaac      900

cccagcctga agtccagagt gaccatcagc cgggacacca gcaagaacca gttcagcctg      960

aagctgtcca gcgtgacagc cgccgacacc gccgtgtact actgcgccga cttcgactac     1020

tggggccagg gcaccctggt caccgtgtcc agcgctagca ccaagggccc cagcgtgttc     1080

cccctggcac ccagcagcaa gagcacatct ggcggaacag ccgctctggg ctgtctggtg     1140

aaagactact tccccgagcc cgtgaccgtg tcttggaact ctggcgccct gaccagcggc     1200

gtgcacacct ttccagccgt gctgcagagc agcggcctgt actccctgtc ctccgtggtc     1260

accgtgccct ctagctccct gggaacacag acatatatct gtaatgtcaa tcacaagcct     1320

tccaacacca aagtcgataa gaaagtcgag cccaagagct gcgacaaaac tcacacatgc     1380

ccaccgtgcc cagcacctga agctgcaggg ggaccgtcag tcttcctctt ccccccaaaa     1440

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg     1500

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1560

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1620

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1680

gccctcggcg cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1740

caggtgtaca ccctgccccc atgccgggat gagctgacca agaaccaggt cagcctgtgg     1800

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1860

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1920

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1980

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     2040

aaa                                                                   2043


<210>  197
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A(VH-CH1)- V9(VH-CL)-Fc(knob) P329G LALA

<400>  197

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
225                 230                 235                 240 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                245                 250                 255     


Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg 
            260                 265                 270         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr 
        275                 280                 285             


Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile 
    290                 295                 300                 


Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
305                 310                 315                 320 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr 
                325                 330                 335     


Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val 
            340                 345                 350         


Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
        355                 360                 365             


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
    370                 375                 380                 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
385                 390                 395                 400 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
                405                 410                 415     


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
            420                 425                 430         


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
        435                 440                 445             


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp 
    450                 455                 460                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
465                 470                 475                 480 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                485                 490                 495     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            500                 505                 510         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        515                 520                 525             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    530                 535                 540                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
545                 550                 555                 560 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                565                 570                 575     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            580                 585                 590         


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        595                 600                 605             


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    610                 615                 620                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
625                 630                 635                 640 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                645                 650                 655     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            660                 665                 670         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        675                 680                 685             


Gly Lys 
    690 


<210>  198
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A(VH-CH1)-V9(VH-CL)-Fc(knob) P329G LALA

<400>  198
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggcc      120

cctggacagg gcctggaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accaccgaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctact atgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agtgctagca caaagggccc cagcgtgttc cctctggccc ctagcagcaa gagcacatct      420

ggcggaacag ccgccctggg ctgcctggtc aaggactact ttcccgagcc cgtgacagtg      480

tcctggaact ctggcgccct gacaagcggc gtgcacacct ttccagccgt gctgcagagc      540

agcggcctgt actctctgag cagcgtggtc accgtgccta gctctagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa      660

cccaagagct gcggcggagg cggatccgga ggcggaggat ccgaagtgca gctggtggaa      720

tctggcggag gcctggtgca gcctggcgga tctctgagac tgagctgtgc cgccagcggc      780

tacagcttca ccggctacac catgaactgg gtgcgccagg cccctggcaa gggactggaa      840

tgggtggccc tgatcaaccc ctacaagggc gtgtccacat acaaccagaa gttcaaggac      900

cggttcacca tcagcgtgga caagagcaag aacaccgcct acctgcagat gaacagcctg      960

cgggccgagg acaccgccgt gtactattgt gccagaagcg gctactacgg cgacagcgac     1020

tggtacttcg acgtgtgggg ccagggcaca ctcgtgaccg tgtcaagcgc tagcgtggcc     1080

gctccctccg tgtttatctt tcccccatcc gatgaacagc tgaaaagcgg caccgcctcc     1140

gtcgtgtgtc tgctgaacaa tttttaccct agggaagcta aagtgcagtg gaaagtggat     1200

aacgcactgc agtccggcaa ctcccaggaa tctgtgacag aacaggactc caaggacagc     1260

acctactccc tgtcctccac cctgacactg tctaaggctg attatgagaa acacaaagtc     1320

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg     1380

ggagagtgtg acaagaccca cacctgtccc ccttgtcctg cccctgaagc tgctggcggc     1440

ccttctgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatcag ccggaccccc     1500

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg     1560

tacgtggacg gcgtggaagt gcacaacgcc aagacaaagc cgcgggagga gcagtacaac     1620

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1680

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1740

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatg ccgggatgag     1800

ctgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc cagcgacatc     1860

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1920

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1980

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     2040

cagaagagcc tctccctgtc tccgggtaaa                                      2070


<210>  199
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2C(VL-CH1)

<400>  199

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Val Glu Pro Lys Ser Cys 
    210                 


<210>  200
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H2C(VL-CH1)

<400>  200
cagaccgtgg tgacacagga acccagcctg accgtctccc ctggcggcac cgtgaccctg       60

acctgtggaa gcagcacagg cgccgtgacc agcggctact accccaactg ggtgcagcag      120

aagcccggcc aggcccctag aggactgatc ggcggcacca agtttctggc ccctggcacc      180

cccgccagat tctctggctc tctgctgggc ggcaaggccg ccctgacact gtctggcgtg      240

cagcctgagg acgaggccga gtactactgc gccctgtggt acagcaacag atgggtgttc      300

ggcggaggca ccaagctgac cgtgctgagc agcgcttcca ccaaaggccc ttccgtgttt      360

cctctggctc ctagctccaa gtccacctct ggaggcaccg ctgctctcgg atgcctcgtg      420

aaggattatt ttcctgagcc tgtgacagtg tcctggaata gcggagcact gacctctgga      480

gtgcatactt tccccgctgt gctgcagtcc tctggactgt acagcctgag cagcgtggtg      540

acagtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      600

agcaacacca aggtggacaa gaaggtggaa cccaagtctt gt                         642


<210>  201
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2C(VH-CL)-M4-3 ML2(VH-CH1)-Fc(knob) P329G LALA

<400>  201

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
                245                 250                 255     


Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr 
            260                 265                 270         


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu 
        275                 280                 285             


Glu Trp Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
    290                 295                 300                 


Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln 
305                 310                 315                 320 


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                325                 330                 335     


Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            340                 345                 350         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        355                 360                 365             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    370                 375                 380                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
385                 390                 395                 400 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                405                 410                 415     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            420                 425                 430         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        435                 440                 445             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    450                 455                 460                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
465                 470                 475                 480 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                485                 490                 495     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            500                 505                 510         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        515                 520                 525             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    530                 535                 540                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
545                 550                 555                 560 


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                565                 570                 575     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
            580                 585                 590         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
        595                 600                 605             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    610                 615                 620                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
625                 630                 635                 640 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                645                 650                 655     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            660                 665                 670         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        675                 680                 


<210>  202
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H2C(VH-CL)-M4-3 ML2(VH-CH1)-Fc(knob) P329G LALA

<400>  202
gaggtgcagc tggtggaaag cggcggagga ctggtgcagc ctggcggaag cctgaagctg       60

tcttgcgccg ccagcggctt caccttcaac aaatacgcca tgaactgggt gcgccaggcc      120

cctggcaagg gactggaatg ggtggcccgg atcagaagca agtacaacaa ctacgccacc      180

tactacgccg acagcgtgaa ggaccggttc accatcagcc gggacgacag caagaacacc      240

gcctacctgc agatgaacaa cctgaaaacc gaggacaccg ccgtgtacta ctgcgtgcgg      300

cacggcaact tcggcaacag ctacatcagc tactgggcct actggggaca gggcaccctg      360

gtgacagtgt ccagcgctag cgtggctgca ccatctgtct tcatcttccc gccatctgat      420

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga      480

gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt      540

gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc      600

aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc      660

tcgcccgtca caaagagctt caacagggga gagtgtggcg gaggcggatc cggcggaggg      720

ggatctcagg tgcagctgca ggaaagcggc cctggcctgg tcaagcccag ccagaccctg      780

agcctgacct gcaccgtgtc cggcggcagc atcaccagcg gctactactg gaactggatt      840

cggcagcacc ccggcaaggg cctggaatgg atcggctaca tcacctacga cggcagcaac      900

aactacaacc ccagcctgaa gtccagagtg accatcagcc gggacaccag caagaaccag      960

ttcagcctga agctgtccag cgtgacagcc gccgacaccg ccgtgtacta ctgcgccgac     1020

ttcgactact ggggccaggg caccctggtc accgtgtcca gcgctagcac caagggcccc     1080

agcgtgttcc ccctggcacc cagcagcaag agcacatctg gcggaacagc cgctctgggc     1140

tgtctggtga aagactactt ccccgagccc gtgaccgtgt cttggaactc tggcgccctg     1200

accagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctccctgtcc     1260

tccgtggtca ccgtgccctc tagctccctg ggaacacaga catatatctg taatgtcaat     1320

cacaagcctt ccaacaccaa agtcgataag aaagtcgagc ccaagagctg cgacaaaact     1380

cacacatgcc caccgtgccc agcacctgaa gctgcagggg gaccgtcagt cttcctcttc     1440

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     1500

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1560

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1620

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1680

tccaacaaag ccctcggcgc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1740

cgagaaccac aggtgtacac cctgccccca tgccgggatg agctgaccaa gaaccaggtc     1800

agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1860

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1920

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1980

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     2040

tctccgggta aa                                                         2052


<210>  203
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  431/26(VL-CL)

<400>  203

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  204
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  431/26(VL-CL)

<400>  204
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta gcaccagcag cagcgtgtcc tacatgcact ggtatcagca gaagcccggc      120

aaggccccca agctgctgat ctacagcacc tccaatctgg ccagcggcgt gcccagcaga      180

ttttctggca gcggctccgg caccgacttc accttcacca tcagctccct gcagcccgag      240

gatatcgcca cctactactg ccaccagtgg tccagctacc ccacctttgg ccagggcacc      300

aaggtggaaa tcaagcgtac ggtggctgca ccatctgtct tcatcttccc gccatctgat      360

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga      420

gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt      480

gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc      540

aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc      600

tcgcccgtca caaagagctt caacagggga gagtgt                                636


<210>  205
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  431/26(VH-CH1)-V9(VH-CL)-Fc(knob) P329G LALA

<400>  205

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
225                 230                 235                 240 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                245                 250                 255     


Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln 
            260                 265                 270         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys 
        275                 280                 285             


Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser 
    290                 295                 300                 


Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
305                 310                 315                 320 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly 
                325                 330                 335     


Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        355                 360                 365             


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    370                 375                 380                 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
385                 390                 395                 400 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                405                 410                 415     


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            420                 425                 430         


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        435                 440                 445             


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys 
    450                 455                 460                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
465                 470                 475                 480 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                485                 490                 495     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            500                 505                 510         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        515                 520                 525             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    530                 535                 540                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
545                 550                 555                 560 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
                565                 570                 575     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            580                 585                 590         


Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
        595                 600                 605             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    610                 615                 620                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
625                 630                 635                 640 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                645                 650                 655     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            660                 665                 670         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685             


Lys 
    


<210>  206
<211>  2067
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  431/26(VH-CH1)-V9(VH-CL)-Fc(knob) P329G LALA

<400>  206
caggtgcagc tgcaggaatc tggccctgga ctcgtgcggc ctagccagac actgagcctg       60

acctgtaccg tgtccggctt caccatcagc agcggctaca gctggcattg ggtgcgccag      120

ccacctggca gaggcctgga atggatcggc tacatccagt acagcggcat caccaactac      180

aaccccagcc tgaagtccag agtgaccatg ctggtggaca cctccaagaa ccagttcagc      240

ctgcggctga gcagcgtgac agccgccgat acagccgtgt actactgcgc cagagaggac      300

tacgactacc actggtactt cgacgtgtgg ggccagggct ctctcgtgac cgtgtcaagc      360

gctagcacaa agggccccag cgtgttccct ctggccccta gcagcaagag cacatctggc      420

ggaacagccg ccctgggctg cctggtcaag gactactttc ccgagcccgt gacagtgtcc      480

tggaactctg gcgccctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtggtcacc gtgcctagct ctagcctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggaaccc      660

aagagctgcg gcggaggcgg atccggaggc ggaggatccg aagtgcagct ggtggaatct      720

ggcggaggcc tggtgcagcc tggcggatct ctgagactga gctgtgccgc cagcggctac      780

agcttcaccg gctacaccat gaactgggtg cgccaggccc ctggcaaggg actggaatgg      840

gtggccctga tcaaccccta caagggcgtg tccacataca accagaagtt caaggaccgg      900

ttcaccatca gcgtggacaa gagcaagaac accgcctacc tgcagatgaa cagcctgcgg      960

gccgaggaca ccgccgtgta ctattgtgcc agaagcggct actacggcga cagcgactgg     1020

tacttcgacg tgtggggcca gggcacactc gtgaccgtgt caagcgctag cgtggccgct     1080

ccctccgtgt ttatctttcc cccatccgat gaacagctga aaagcggcac cgcctccgtc     1140

gtgtgtctgc tgaacaattt ttaccctagg gaagctaaag tgcagtggaa agtggataac     1200

gcactgcagt ccggcaactc ccaggaatct gtgacagaac aggactccaa ggacagcacc     1260

tactccctgt cctccaccct gacactgtct aaggctgatt atgagaaaca caaagtctac     1320

gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga     1380

gagtgtgaca agacccacac ctgtccccct tgtcctgccc ctgaagctgc tggcggccct     1440

tctgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa     1500

gtgacctgcg tggtggtgga tgtgtcccac gaggaccctg aagtgaagtt caattggtac     1560

gtggacggcg tggaagtgca caacgccaag acaaagccgc gggaggagca gtacaacagc     1620

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1680

tacaagtgca aggtctccaa caaagccctc ggcgccccca tcgagaaaac catctccaaa     1740

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgccg ggatgagctg     1800

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc     1860

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1920

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1980

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     2040

aagagcctct ccctgtctcc gggtaaa                                         2067


<210>  207
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  431/26(VH-CH1)-Fc(hole) P329G LALA

<400>  207

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  208
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  431/26(VH-CH1)-Fc(hole) P329G LALA

<400>  208
caggtgcagc tgcaggaatc tggccctgga ctcgtgcggc ctagccagac actgagcctg       60

acctgtaccg tgtccggctt caccatcagc agcggctaca gctggcattg ggtgcgccag      120

ccacctggca gaggcctgga atggatcggc tacatccagt acagcggcat caccaactac      180

aaccccagcc tgaagtccag agtgaccatg ctggtggaca cctccaagaa ccagttcagc      240

ctgcggctga gcagcgtgac agccgccgat acagccgtgt actactgcgc cagagaggac      300

tacgactacc actggtactt cgacgtgtgg ggccagggct ctctcgtgac cgtgtcaagc      360

gctagcacca agggcccctc cgtgttcccc ctggccccca gcagcaagag caccagcggc      420

ggcacagccg ctctgggctg cctggtcaag gactacttcc ccgagcccgt gaccgtgtcc      480

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagttct      540

ggcctgtata gcctgagcag cgtggtcacc gtgccttcta gcagcctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      660

aagagctgcg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgcaggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtgcaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctctcgtgc gcagtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcgtg agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  209
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A(VL-CL)-V9 (VH-CL)

<400>  209

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
225                 230                 235                 240 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                245                 250                 255     


Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro 
        275                 280                 285             


Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr 
    290                 295                 300                 


Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
305                 310                 315                 320 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
                325                 330                 335     


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
            340                 345                 350         


Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe 
        355                 360                 365             


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
    370                 375                 380                 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
385                 390                 395                 400 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
                405                 410                 415     


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
            420                 425                 430         


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
        435                 440                 445             


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    450                 455                 460                 


<210>  210
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A(VL-CL)-V9 (VH-CL)

<400>  210
gatatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacatgca aggcctctgc cgccgtgggc acatacgtgg cctggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacagc gccagctacc ggaagagagg cgtgcccagc      180

agattttccg gcagcggctc tggcaccgac ttcaccctga ccatcagctc cctgcagccc      240

gaggacttcg ccacctacta ctgccaccag tactacacct accccctgtt caccttcggc      300

cagggcacca agctcgagat caagcgtacg gtggccgctc ccagcgtgtt catcttccca      360

cctagcgacg agcagctgaa gtccggcaca gcctctgtcg tgtgcctgct gaacaacttc      420

tacccccgcg aggccaaggt gcagtggaag gtggacaatg ccctgcagag cggcaacagc      480

caggaaagcg tgaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg      540

acactgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacccaccag      600

ggcctgtcta gccccgtgac caagagcttc aaccggggcg aatgtggcgg cggaggatcc      660

ggcggaggcg gctccggagg cggaggaagt ggcggagggg gatctgaagt gcagctggtg      720

gaatctggcg gaggcctggt gcagcctggc ggatctctga gactgagctg tgccgccagc      780

ggctacagct tcaccggcta caccatgaac tgggtgcgcc aggcccctgg caagggactg      840

gaatgggtgg ccctgatcaa cccctacaag ggcgtgtcca catacaacca gaagttcaag      900

gaccggttca ccatcagcgt ggacaagagc aagaacaccg cctacctgca gatgaacagc      960

ctgcgggccg aggacaccgc cgtgtactac tgtgccagaa gcggctacta cggcgacagc     1020

gactggtact tcgacgtgtg gggccaggga accctcgtga ccgtgtcaag cgctagcgtg     1080

gccgcaccct ctgtgtttat ctttccaccc tctgacgaac agctgaaaag cggcaccgcc     1140

agcgtcgtgt gtctgctgaa caatttttac cctagggaag ctaaagtgca gtggaaagtg     1200

gataacgcac tgcagtccgg caactcccag gaatctgtga cagaacagga ctccaaggac     1260

agcacatact ccctgtccag cacactgacc ctgtctaagg ccgattatga gaaacacaaa     1320

gtgtatgctt gtgaagtgac acatcaggga ctgagcagcc ctgtgacaaa gtccttcaac     1380

agaggcgagt gt                                                         1392


<210>  211
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1A1A(VH-CH1)-Fc(knob) P329G LALA

<400>  211

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  212
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH1A1A(VH-CH1)-Fc(knob) P329G LALA

<400>  212
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcctatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agcgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agctgcaggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcggcg cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atgccgggat     1080

gagctgacca agaaccaggt cagcctgtgg tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  213
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(hole) P329G LALA

<400>  213

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  214
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(hole) P329G LALA

<400>  214
gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  215
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH2527(VL-CH1)

<400>  215

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Val Glu Pro Lys Ser Cys 
    210                 


<210>  216
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH2527(VL-CH1)

<400>  216
caggccgtcg tgacccagga aagcgccctg acaacaagcc ctggcgagac agtgaccctg       60

acctgcagat ctagcacagg cgccgtgacc accagcaact acgccaactg ggtgcaggaa      120

aagcccgacc acctgttcac cggcctgatc ggcggcacca acaaaagggc tccaggcgtg      180

ccagccagat tcagcggcag cctgattggc gataaggccg ccctgaccat cactggcgcc      240

cagacagagg acgaggccat ctacttttgc gccctgtggt acagcaacct gtgggtgttc      300

ggcggaggca ccaagctgac agtgctgagc agcgcttcca ccaaaggccc ttccgtgttt      360

cctctggctc ctagctccaa gtccacctct ggaggcaccg ctgctctcgg atgcctcgtg      420

aaggattatt ttcctgagcc tgtgacagtg tcctggaata gcggagcact gacctctgga      480

gtgcatactt tccccgctgt gctgcagtcc tctggactgt acagcctgag cagcgtggtg      540

acagtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      600

agcaacacca aggtggacaa gaaggtggaa cccaagtctt gt                         642


<210>  217
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH2527(VH-CL)-LC007(VH-CH1)-Fc(knob) P329G LALA

<400>  217

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
                245                 250                 255     


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
            260                 265                 270         


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
        275                 280                 285             


Glu Trp Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
    290                 295                 300                 


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
305                 310                 315                 320 


Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
                325                 330                 335     


Tyr Cys Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            340                 345                 350         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        355                 360                 365             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    370                 375                 380                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
385                 390                 395                 400 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                405                 410                 415     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            420                 425                 430         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        435                 440                 445             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    450                 455                 460                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
465                 470                 475                 480 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                485                 490                 495     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            500                 505                 510         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        515                 520                 525             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    530                 535                 540                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
545                 550                 555                 560 


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                565                 570                 575     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
            580                 585                 590         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
        595                 600                 605             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    610                 615                 620                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
625                 630                 635                 640 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                645                 650                 655     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            660                 665                 670         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        675                 680                 


<210>  218
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH2527(VH-CL)-LC007(VH-CH1)-Fc(knob) P329G LALA

<400>  218
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctaagggctc tctgaagctg       60

agctgtgccg ccagcggctt caccttcaac acctacgcca tgaactgggt gcgccaggcc      120

cctggcaaag gcctggaatg ggtggcccgg atcagaagca agtacaacaa ttacgccacc      180

tactacgccg acagcgtgaa ggaccggttc accatcagcc gggacgacag ccagagcatc      240

ctgtacctgc agatgaacaa cctgaaaacc gaggacaccg ccatgtacta ctgcgtgcgg      300

cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcaccctc      360

gtgacagtgt ctgctgctag cgtggctgca ccatctgtct tcatcttccc gccatctgat      420

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga      480

gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt      540

gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc      600

aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc      660

tcgcccgtca caaagagctt caacagggga gagtgtggcg gaggcggatc cggcggaggg      720

ggatctgagg tccagctgca ggagtcagga cctggcctcg tgaaaccttc tcagtctctg      780

tctctcacct gctctgtcac tggctactcc atcaccagtg gttattactg gaactggatt      840

cggcagtttc caggaaacaa gctggaatgg atgggctaca taacctacga cggtagcaat      900

aactacaacc catctctcaa aaatcgaatc tccattactc gtgacacatc taagaaccag      960

tttttcctga agttgaattc tgtgactact gaggacacag ctacatatta ctgtgcggac     1020

tttgactact ggggccaagg caccactctc acagtctcca gcgctagcac caagggcccc     1080

agcgtgttcc ccctggcacc cagcagcaag agcacatctg gcggaacagc cgctctgggc     1140

tgtctggtga aagactactt ccccgagccc gtgaccgtgt cttggaactc tggcgccctg     1200

accagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctccctgtcc     1260

tccgtggtca ccgtgccctc tagctccctg ggaacacaga catatatctg taatgtcaat     1320

cacaagcctt ccaacaccaa agtcgataag aaagtcgagc ccaagagctg cgacaaaact     1380

cacacatgcc caccgtgccc agcacctgaa gctgcagggg gaccgtcagt cttcctcttc     1440

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     1500

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1560

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1620

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1680

tccaacaaag ccctcggcgc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1740

cgagaaccac aggtgtacac cctgccccca tgccgggatg agctgaccaa gaaccaggtc     1800

agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1860

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1920

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1980

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     2040

tctccgggta aa                                                         2052


<210>  219
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007(VH-CH1)-CH2527(VH-CL)-Fc(knob) P329G LALA

<400>  219

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
225                 230                 235                 240 


Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
                245                 250                 255     


Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            260                 265                 270         


Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
        275                 280                 285             


Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln 
    290                 295                 300                 


Ser Ile Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
305                 310                 315                 320 


Met Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser 
                325                 330                 335     


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala 
            340                 345                 350         


Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        355                 360                 365             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    370                 375                 380                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
385                 390                 395                 400 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                405                 410                 415     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            420                 425                 430         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        435                 440                 445             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys 
    450                 455                 460                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
465                 470                 475                 480 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                485                 490                 495     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            500                 505                 510         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        515                 520                 525             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    530                 535                 540                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
545                 550                 555                 560 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                565                 570                 575     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            580                 585                 590         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        595                 600                 605             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    610                 615                 620                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
625                 630                 635                 640 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                645                 650                 655     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            660                 665                 670         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        675                 680                 685 


<210>  220
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007(VH-CH1)-CH2527(VH-CL)-Fc(knob) P329G LALA

<400>  220
gaggtgcagc tgcaggaatc tggccctggc ctggtcaagc caagccagag tctgagcctg       60

acctgcagcg tgaccggcta cagcattacc agcggctact actggaactg gattcggcag      120

ttccccggca ataagctgga atggatgggc tacatcacct acgacggcag caacaactac      180

aaccccagcc tgaagaaccg gatcagcatc acccgggaca ccagcaagaa ccagttcttc      240

ctgaagctga acagcgtgac caccgaggac accgccacat actattgcgc cgacttcgac      300

tactggggcc agggcaccac cctgaccgtg tccagcgcca gcacaaaggg ccctagcgtg      360

ttccctctgg cccccagcag caagagcaca agcggcggaa cagccgccct gggctgcctc      420

gtgaaggact acttccccga gcccgtgaca gtgtcttgga acagcggagc cctgacaagc      480

ggcgtgcaca ccttccctgc cgtgctgcag agcagcggcc tgtactccct gagcagcgtg      540

gtcaccgtgc ctagcagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      600

cccagcaaca ccaaagtgga caagaaggtg gagcccaaga gctgtgatgg cggaggaggg      660

tccggaggcg gaggatccga agtgcagctg gtggaaagcg gcggaggcct ggtgcagcct      720

aagggctctc tgaagctgag ctgtgccgcc agcggcttca ccttcaacac ctacgccatg      780

aactgggtgc gccaggcccc tggcaaaggc ctggaatggg tggcccggat cagaagcaag      840

tacaacaatt acgccaccta ctacgccgac agcgtgaagg accggttcac catcagccgg      900

gacgacagcc agagcatcct gtacctgcag atgaacaacc tgaaaaccga ggacaccgcc      960

atgtactact gcgtgcggca cggcaacttc ggcaacagct atgtgtcttg gtttgcctac     1020

tggggccagg gcaccctcgt gacagtgtct gctgctagcg tggccgctcc ctccgtgttt     1080

atctttcccc catccgatga acagctgaaa agcggcaccg cctccgtcgt gtgtctgctg     1140

aacaattttt accctaggga agctaaagtg cagtggaaag tggataacgc actgcagtcc     1200

ggcaactccc aggaatctgt gacagaacag gactccaagg acagcaccta ctccctgtcc     1260

tccaccctga cactgtctaa ggctgattat gagaaacaca aagtctacgc ctgcgaagtc     1320

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtgacaag     1380

acccacacct gtcccccttg tcctgcccct gaagctgctg gcggcccttc tgtgttcctg     1440

ttccccccaa agcccaagga caccctgatg atcagccgga cccccgaagt gacctgcgtg     1500

gtggtggatg tgtcccacga ggaccctgaa gtgaagttca attggtacgt ggacggcgtg     1560

gaagtgcaca acgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1620

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1680

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1740

ccccgagaac cacaggtgta caccctgccc ccatgccggg atgagctgac caagaaccag     1800

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1860

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1920

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1980

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     2040

ctgtctccgg gtaaa                                                      2055


<210>  221
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33(VL-CL)

<400>  221

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  222
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD33(VL-CL)

<400>  222
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcga gagcgtggac aactacggca tcagcttcat gaactggttc      120

cagcagaagc ccggcaaggc ccccaagctg ctgatctacg ccgccagcaa tcagggcagc      180

ggcgtgccca gcagattcag cggctctggc agcggcaccg acttcaccct gaccatcagc      240

agcctgcagc ccgacgactt cgccacctac tactgccagc agagcaaaga ggtgccctgg      300

accttcggcc agggcaccaa ggtggaaatc aagcgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  223
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9(VL-CH1)-anti-CD33(VH-CH1)-Fc(knob) P329G LALA

<400>  223

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    210                 215                 220                 


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
225                 230                 235                 240 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met 
                245                 250                 255     


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
            260                 265                 270         


Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys Ser 
        275                 280                 285             


Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr Met Glu 
    290                 295                 300                 


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
305                 310                 315                 320 


Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                325                 330                 335     


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
            340                 345                 350         


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
        355                 360                 365             


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
    370                 375                 380                 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
385                 390                 395                 400 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
                405                 410                 415     


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
            420                 425                 430         


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
        435                 440                 445             


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
    450                 455                 460                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
465                 470                 475                 480 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                485                 490                 495     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            500                 505                 510         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        515                 520                 525             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    530                 535                 540                 


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
545                 550                 555                 560 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                565                 570                 575     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            580                 585                 590         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        595                 600                 605             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    610                 615                 620                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
625                 630                 635                 640 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                645                 650                 655     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665             


<210>  224
<211>  2004
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9(VL-CH1)-anti-CD33(VH-CH1)-Fc(knob) P329G LALA

<400>  224
gatatccaga tgacccagag ccccagctct ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagac tggaaagcgg cgtgccctcc      180

agattttccg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggatttcg ccacatatta ctgccagcag ggcaataccc tgccctggac cttcggacag      300

ggcacaaaag tggaaatcaa gagcagcgct tccaccaaag gcccttccgt gtttcctctg      360

gctcctagct ccaagtccac ctctggaggc accgctgctc tcggatgcct cgtgaaggat      420

tattttcctg agcctgtgac agtgtcctgg aatagcggag cactgacctc tggagtgcat      480

actttccccg ctgtgctgca gtcctctgga ctgtacagcc tgagcagcgt ggtgacagtg      540

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaac      600

accaaggtgg acaagaaggt ggaacccaag tcttgtggcg gaggcggatc cggcggaggc      660

ggatctcagg tgcagctggt gcagtctggc gccgaagtga agaaacccgg cagcagcgtg      720

aaggtgtcct gcaaggccag cggctacacc ttcaccgact acaacatgca ctgggtccgc      780

caggccccag gccagggact ggaatggatc ggctacatct acccctacaa cggcggcacc      840

ggctacaacc agaagttcaa gagcaaggcc accatcaccg ccgacgagag caccaacacc      900

gcctacatgg aactgagcag cctgcggagc gaggacaccg ccgtgtacta ctgcgccaga      960

ggcagacccg ccatggacta ctggggccag ggcaccctgg tgacagtgtc cagcgccagc     1020

acaaagggcc ccagcgtgtt ccccctggca cccagcagca agagcacatc tggcggaaca     1080

gccgctctgg gctgtctggt gaaagactac ttccccgagc ccgtgaccgt gtcttggaac     1140

tctggcgccc tgaccagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg     1200

tactccctgt cctccgtggt caccgtgccc tctagctccc tgggaacaca gacatatatc     1260

tgtaatgtca atcacaagcc ttccaacacc aaagtcgata agaaagtcga gcccaagagc     1320

tgcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca     1380

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1440

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1500

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1560

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1620

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1680

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1740

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1800

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1860

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1920

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1980

agcctctccc tgtctccggg taaa                                            2004


<210>  225
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33(VH-CH1)-Fc(hole) P329G LALA

<400>  225

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  226
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD33(VH-CH1)-Fc(hole) P329G LALA

<400>  226
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggcagcag cgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gactacaaca tgcactgggt ccgccaggcc      120

ccaggccagg gactggaatg gatcggctac atctacccct acaacggcgg caccggctac      180

aaccagaagt tcaagagcaa ggccaccatc accgccgacg agagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagaggcaga      300

cccgccatgg actactgggg ccagggcacc ctggtgacag tgtccagcgc tagcaccaag      360

ggcccctccg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgct      420

ctgggctgcc tggtcaagga ctacttcccc gagcccgtga ccgtgtcctg gaacagcgga      480

gccctgacct ccggcgtgca caccttcccc gccgtgctgc agagttctgg cctgtatagc      540

ctgagcagcg tggtcaccgt gccttctagc agcctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgcgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtgcaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tctcgtgcgc agtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  227
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD20(VL-CL)

<400>  227

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  228
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD20(VL-CL)

<400>  228
gatatcgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gcccgccagc       60

attagctgca ggtctagcaa gagcctcttg cacagcaatg gcatcactta tttgtattgg      120

tacctgcaaa agccagggca gtctccacag ctcctgattt atcaaatgtc caaccttgtc      180

tctggcgtcc ctgaccggtt ctccggatcc gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgcg ctcagaatct agaacttcct      300

tacaccttcg gcggagggac caaggtggag atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  229
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V9(VL-CH1)-anti-CD20(VH-CH1)-Fc(knob) P329G LALA

<400>  229

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    210                 215                 220                 


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
225                 230                 235                 240 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile 
                245                 250                 255     


Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg 
            260                 265                 270         


Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly 
        275                 280                 285             


Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
    290                 295                 300                 


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
305                 310                 315                 320 


Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu 
                325                 330                 335     


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            340                 345                 350         


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        355                 360                 365             


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    370                 375                 380                 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
385                 390                 395                 400 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                405                 410                 415     


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            420                 425                 430         


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
        435                 440                 445             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
    450                 455                 460                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
465                 470                 475                 480 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                485                 490                 495     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            500                 505                 510         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        515                 520                 525             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    530                 535                 540                 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
545                 550                 555                 560 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                565                 570                 575     


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
            580                 585                 590         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        595                 600                 605             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    610                 615                 620                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
625                 630                 635                 640 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                645                 650                 655     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665                 670     


<210>  230
<211>  2013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V9(VL-CH1)-anti-CD20(VH-CH1)-Fc(knob) P329G LALA

<400>  230
gatatccaga tgacccagag ccccagctct ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca ggacatcaga aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagac tggaaagcgg cgtgccctcc      180

agattttccg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagccc      240

gaggatttcg ccacatatta ctgccagcag ggcaataccc tgccctggac cttcggacag      300

ggcacaaaag tggaaatcaa gagcagcgct tccaccaaag gcccttccgt gtttcctctg      360

gctcctagct ccaagtccac ctctggaggc accgctgctc tcggatgcct cgtgaaggat      420

tattttcctg agcctgtgac agtgtcctgg aatagcggag cactgacctc tggagtgcat      480

actttccccg ctgtgctgca gtcctctgga ctgtacagcc tgagcagcgt ggtgacagtg      540

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaac      600

accaaggtgg acaagaaggt ggaacccaag tcttgtggcg gaggcggatc cggcggaggg      660

ggatctcagg tgcaattggt gcagtctggc gctgaagtta agaagcctgg gagttcagtg      720

aaggtctcct gcaaggcttc cggatacgcc ttcagctatt cttggatcaa ttgggtgcgg      780

caggcgcctg gacaagggct cgagtggatg ggacggatct ttcccggcga tggggatact      840

gactacaatg ggaaattcaa gggcagagtc acaattaccg ccgacaaatc cactagcaca      900

gcctatatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcaaga      960

aatgtctttg atggttactg gcttgtttac tggggccagg gaaccctggt caccgtctcc     1020

tcagctagca ccaagggccc cagcgtgttc cccctggcac ccagcagcaa gagcacatct     1080

ggcggaacag ccgctctggg ctgtctggtg aaagactact tccccgagcc cgtgaccgtg     1140

tcttggaact ctggcgccct gaccagcggc gtgcacacct ttccagccgt gctgcagagc     1200

agcggcctgt actccctgtc ctccgtggtc accgtgccct ctagctccct gggaacacag     1260

acatatatct gtaatgtcaa tcacaagcct tccaacacca aagtcgataa gaaagtcgag     1320

cccaagagct gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga agctgcaggg     1380

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1440

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1500

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1560

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1620

aaggagtaca agtgcaaggt ctccaacaaa gccctcggcg cccccatcga gaaaaccatc     1680

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atgccgggat     1740

gagctgacca agaaccaggt cagcctgtgg tgcctggtca aaggcttcta tcccagcgac     1800

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1860

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1920

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1980

acgcagaaga gcctctccct gtctccgggt aaa                                  2013


<210>  231
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD20(VH-CH1)-Fc(hole) P329G LALA

<400>  231

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  232
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD20(VH-CH1)-Fc(hole) P329G LALA

<400>  232
caggtgcaat tggtgcagtc tggcgctgaa gttaagaagc ctgggagttc agtgaaggtc       60

tcctgcaagg cttccggata cgccttcagc tattcttgga tcaattgggt gcggcaggcg      120

cctggacaag ggctcgagtg gatgggacgg atctttcccg gcgatgggga tactgactac      180

aatgggaaat tcaagggcag agtcacaatt accgccgaca aatccactag cacagcctat      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagaaatgtc      300

tttgatggtt actggcttgt ttactggggc cagggaaccc tggtcaccgt ctcctcagct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagctgc agggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ggcgccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tgcaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct ctcgtgcgca gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  233
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 HCDR1

<400>  233

Gly Gly Ser Ile Thr Ser Gly Tyr Tyr Trp Asn 
1               5                   10      


<210>  234
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 HCDR1

<400>  234
ggcggcagca tcaccagcgg ctactactgg aac                                    33


<210>  235
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 HCDR2

<400>  235

Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  236
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 HCDR2

<400>  236
tacatcacct acgacggcag caacaactac aaccccagcc tgaagtcc                    48


<210>  237
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 HCDR3

<400>  237

Phe Asp Tyr 
1           


<210>  238
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 HCDR3

<400>  238
ttcgactac                                                                9


<210>  239
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 VH

<400>  239

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  240
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 VH

<400>  240
caggtgcagc tgcaggaaag cggccctggc ctggtcaagc ccagccagac cctgagcctg       60

acctgcaccg tgtccggcgg cagcatcacc agcggctact actggaactg gatccggcag      120

caccccggca agggcctgga atggatcggc tacatcacct acgacggcag caacaactac      180

aaccccagcc tgaagtccag agtgaccatc agccgggaca ccagcaagaa ccagttcagc      240

ctgaagctgt ccagcgtgac agccgccgac accgccgtgt actactgcgc cgacttcgac      300

tactggggcc agggcaccct ggtcaccgtg tccagc                                336


<210>  241
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 LCDR1

<400>  241

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  242
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 LCDR1

<400>  242
cgggccagcc agggcatccg gaactacctg aac                                    33


<210>  243
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 LCDR2

<400>  243

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  244
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 LCDR2

<400>  244
tacaccagca gcctgcacag c                                                 21


<210>  245
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 LCDR3

<400>  245

Gln Gln Tyr Ser Lys Leu Pro Trp Thr 
1               5                   


<210>  246
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 LCDR3

<400>  246
cagcagtaca gcaagctgcc ctggacc                                           27


<210>  247
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 VL

<400>  247

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  248
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M4-3 ML2 VL

<400>  248
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgcc gggccagcca gggcatccgg aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagcc tgcacagcgg cgtgcctagc      180

cggtttagcg gcagcggctc cggcaccgac ttcaccctga ccattagctc cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacagcaagc tgccctggac cttcggccag      300

ggaacaaagg tggagatcaa g                                                321


<210>  249
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 HCDR1

<400>  249

Thr Tyr Ala Met Asn 
1               5   


<210>  250
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 HCDR1

<400>  250
acctacgcca tgaac                                                        15


<210>  251
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 HCDR2

<400>  251

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  252
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 HCDR2

<400>  252
cggatcagaa gcaagtacaa caattacgcc acctactacg ccgacagcgt gaaggac          57


<210>  253
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 HCDR3

<400>  253

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  254
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 HCDR3

<400>  254
cacggcaact tcggcaacag ctatgtgtct tggtttgcct ac                          42


<210>  255
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH

<400>  255

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 


<210>  256
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VH

<400>  256
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctaagggctc tctgaagctg       60

agctgtgccg ccagcggctt caccttcaac acctacgcca tgaactgggt gcgccaggcc      120

cctggcaaag gcctggaatg ggtggcccgg atcagaagca agtacaacaa ttacgccacc      180

tactacgccg acagcgtgaa ggaccggttc accatcagcc gggacgacag ccagagcatc      240

ctgtacctgc agatgaacaa cctgaaaacc gaggacaccg ccatgtacta ctgcgtgcgg      300

cacggcaact tcggcaacag ctatgtgtct tggtttgcct actggggcca gggcaccctc      360

gtgacagtgt ctgct                                                       375


<210>  257
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 LCDR1

<400>  257

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  258
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 LCDR1

<400>  258
agatctagca caggcgccgt gaccaccagc aactacgcca ac                          42


<210>  259
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 LCDR2

<400>  259

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  260
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 LCDR2

<400>  260
ggcaccaaca aaagggctcc a                                                 21


<210>  261
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 LCDR3

<400>  261

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  262
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 LCDR3

<400>  262
gccctgtggt acagcaacct gtgggtg                                           27


<210>  263
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VL

<400>  263

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  264
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 VL

<400>  264
caggccgtcg tgacccagga aagcgccctg acaacaagcc ctggcgagac agtgaccctg       60

acctgcagat ctagcacagg cgccgtgacc accagcaact acgccaactg ggtgcaggaa      120

aagcccgacc acctgttcac cggcctgatc ggcggcacca acaaaagggc tccaggcgtg      180

ccagccagat tcagcggcag cctgattggc gataaggccg ccctgaccat cactggcgcc      240

cagacagagg acgaggccat ctacttttgc gccctgtggt acagcaacct gtgggtgttc      300

ggcggaggca ccaagctgac agtgctg                                          327


<210>  265
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  266
<211>  198
<212>  PRT
<213>  Macaca fascicularis

<400>  266

Met Gln Ser Gly Thr Arg Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Ile Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Gln Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Ser Gln His Leu Gly Ser Glu Ala Gln Trp Gln His Asn Gly Lys 
    50                  55                  60                  


Asn Lys Glu Asp Ser Gly Asp Arg Leu Phe Leu Pro Glu Phe Ser Glu 
65                  70                  75                  80  


Met Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Asn Pro 
                85                  90                  95      


Glu Asp Ala Ser His His Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn 
            100                 105                 110         


Cys Met Glu Met Asp Val Met Ala Val Ala Thr Ile Val Ile Val Asp 
        115                 120                 125             


Ile Cys Ile Thr Leu Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys 
    130                 135                 140                 


Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly 
145                 150                 155                 160 


Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn 
                165                 170                 175     


Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Gln Asp Leu Tyr Ser Gly 
            180                 185                 190         


Leu Asn Gln Arg Arg Ile 
        195             


