                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  Anti-MCSP Antibodies

<130>  30603

<150>  EP 11178393.2
<151>  2011-08-23

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  2
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Val Pro Glu Ala Ala Arg Thr Glu Ala Gly Lys Pro Glu Ser Ser 
1               5                   10                  15      


Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser Ser Pro Glu Pro Ala 
            20                  25                  30          


Val Ala Lys Gly Gly Phe Leu Ser Phe Leu Glu Ala Asn 
        35                  40                  45  


<210>  3
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Leu Pro Ser Ala Ile Glu Val Gln Leu Arg Ala Pro Leu Glu Val 
1               5                   10                  15      


Pro Gln Ala Leu Gly Arg Ser Ser Leu Ser Gln Gln Gln Leu Arg Val 
            20                  25                  30          


Val Ser Asp Arg Glu Glu Pro Glu Ala Ala Tyr Arg Leu Ile Gln Gly 
        35                  40                  45              


Pro Gln Tyr Gly His Leu Leu Val Gly Gly Arg Pro Thr Ser Ala Phe 
    50                  55                  60                  


Ser Gln Phe Gln Ile Asp Gln Gly Glu Val Val Phe Ala Phe Thr Asn 
65                  70                  75                  80  


Phe Ser Ser Ser His Asp His Phe Arg Val Leu Ala Leu Ala Arg Gly 
                85                  90                  95      


Val Asn Ala Ser Ala Val Val Asn Val Thr Val 
            100                 105         


<210>  4
<211>  203
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (182)..(203)
<223>  Transmembrane Domain

<400>  4

Arg Ala Leu Leu His Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Ala 
1               5                   10                  15      


Thr Leu Arg Leu Asp Pro Thr Val Leu Asp Ala Gly Glu Leu Ala Asn 
            20                  25                  30          


Arg Thr Gly Ser Val Pro Arg Phe Arg Leu Leu Glu Gly Pro Arg His 
        35                  40                  45              


Gly Arg Val Val Arg Val Pro Arg Ala Arg Thr Glu Pro Gly Gly Ser 
    50                  55                  60                  


Gln Leu Val Glu Gln Phe Thr Gln Gln Asp Leu Glu Asp Gly Arg Leu 
65                  70                  75                  80  


Gly Leu Glu Val Gly Arg Pro Glu Gly Arg Ala Pro Gly Pro Ala Gly 
                85                  90                  95      


Asp Ser Leu Thr Leu Glu Leu Trp Ala Gln Gly Val Pro Pro Ala Val 
            100                 105                 110         


Ala Ser Leu Asp Phe Ala Thr Glu Pro Tyr Asn Ala Ala Arg Pro Tyr 
        115                 120                 125             


Ser Val Ala Leu Leu Ser Val Pro Glu Ala Ala Arg Thr Glu Ala Gly 
    130                 135                 140                 


Lys Pro Glu Ser Ser Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser 
145                 150                 155                 160 


Ser Pro Glu Pro Ala Val Ala Lys Gly Gly Phe Leu Ser Phe Leu Glu 
                165                 170                 175     


Ala Asn Met Phe Ser Val Ile Ile Pro Met Cys Leu Val Leu Leu Leu 
            180                 185                 190         


Leu Ala Leu Ile Leu Pro Leu Leu Phe Tyr Leu 
        195                 200             


<210>  5
<211>  310
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Domain
<222>  (289)..(310)
<223>  Transmembrane Domain

<400>  5

Ile Leu Pro Ser Ala Ile Glu Val Gln Leu Arg Ala Pro Leu Glu Val 
1               5                   10                  15      


Pro Gln Ala Leu Gly Arg Ser Ser Leu Ser Gln Gln Gln Leu Arg Val 
            20                  25                  30          


Val Ser Asp Arg Glu Glu Pro Glu Ala Ala Tyr Arg Leu Ile Gln Gly 
        35                  40                  45              


Pro Gln Tyr Gly His Leu Leu Val Gly Gly Arg Pro Thr Ser Ala Phe 
    50                  55                  60                  


Ser Gln Phe Gln Ile Asp Gln Gly Glu Val Val Phe Ala Phe Thr Asn 
65                  70                  75                  80  


Phe Ser Ser Ser His Asp His Phe Arg Val Leu Ala Leu Ala Arg Gly 
                85                  90                  95      


Val Asn Ala Ser Ala Val Val Asn Val Thr Val Arg Ala Leu Leu His 
            100                 105                 110         


Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Ala Thr Leu Arg Leu Asp 
        115                 120                 125             


Pro Thr Val Leu Asp Ala Gly Glu Leu Ala Asn Arg Thr Gly Ser Val 
    130                 135                 140                 


Pro Arg Phe Arg Leu Leu Glu Gly Pro Arg His Gly Arg Val Val Arg 
145                 150                 155                 160 


Val Pro Arg Ala Arg Thr Glu Pro Gly Gly Ser Gln Leu Val Glu Gln 
                165                 170                 175     


Phe Thr Gln Gln Asp Leu Glu Asp Gly Arg Leu Gly Leu Glu Val Gly 
            180                 185                 190         


Arg Pro Glu Gly Arg Ala Pro Gly Pro Ala Gly Asp Ser Leu Thr Leu 
        195                 200                 205             


Glu Leu Trp Ala Gln Gly Val Pro Pro Ala Val Ala Ser Leu Asp Phe 
    210                 215                 220                 


Ala Thr Glu Pro Tyr Asn Ala Ala Arg Pro Tyr Ser Val Ala Leu Leu 
225                 230                 235                 240 


Ser Val Pro Glu Ala Ala Arg Thr Glu Ala Gly Lys Pro Glu Ser Ser 
                245                 250                 255     


Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser Ser Pro Glu Pro Ala 
            260                 265                 270         


Val Ala Lys Gly Gly Phe Leu Ser Phe Leu Glu Ala Asn Met Phe Ser 
        275                 280                 285             


Val Ile Ile Pro Met Cys Leu Val Leu Leu Leu Leu Ala Leu Ile Leu 
    290                 295                 300                 


Pro Leu Leu Phe Tyr Leu 
305                 310 


<210>  6
<211>  419
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Domain
<222>  (398)..(419)
<223>  Transmembrane Domain

<400>  6

Val Asn Glu Arg Pro Pro Gln Pro Gln Ala Ser Val Pro Leu Arg Leu 
1               5                   10                  15      


Thr Arg Gly Ser Arg Ala Pro Ile Ser Arg Ala Gln Leu Ser Val Val 
            20                  25                  30          


Asp Pro Asp Ser Ala Pro Gly Glu Ile Glu Tyr Glu Val Gln Arg Ala 
        35                  40                  45              


Pro His Asn Gly Phe Leu Ser Leu Val Gly Gly Gly Leu Gly Pro Val 
    50                  55                  60                  


Thr Arg Phe Thr Gln Ala Asp Val Asp Ser Gly Arg Leu Ala Phe Val 
65                  70                  75                  80  


Ala Asn Gly Ser Ser Val Ala Gly Ile Phe Gln Leu Ser Met Ser Asp 
                85                  90                  95      


Gly Ala Ser Pro Pro Leu Pro Met Ser Leu Ala Val Asp Ile Leu Pro 
            100                 105                 110         


Ser Ala Ile Glu Val Gln Leu Arg Ala Pro Leu Glu Val Pro Gln Ala 
        115                 120                 125             


Leu Gly Arg Ser Ser Leu Ser Gln Gln Gln Leu Arg Val Val Ser Asp 
    130                 135                 140                 


Arg Glu Glu Pro Glu Ala Ala Tyr Arg Leu Ile Gln Gly Pro Gln Tyr 
145                 150                 155                 160 


Gly His Leu Leu Val Gly Gly Arg Pro Thr Ser Ala Phe Ser Gln Phe 
                165                 170                 175     


Gln Ile Asp Gln Gly Glu Val Val Phe Ala Phe Thr Asn Phe Ser Ser 
            180                 185                 190         


Ser His Asp His Phe Arg Val Leu Ala Leu Ala Arg Gly Val Asn Ala 
        195                 200                 205             


Ser Ala Val Val Asn Val Thr Val Arg Ala Leu Leu His Val Trp Ala 
    210                 215                 220                 


Gly Gly Pro Trp Pro Gln Gly Ala Thr Leu Arg Leu Asp Pro Thr Val 
225                 230                 235                 240 


Leu Asp Ala Gly Glu Leu Ala Asn Arg Thr Gly Ser Val Pro Arg Phe 
                245                 250                 255     


Arg Leu Leu Glu Gly Pro Arg His Gly Arg Val Val Arg Val Pro Arg 
            260                 265                 270         


Ala Arg Thr Glu Pro Gly Gly Ser Gln Leu Val Glu Gln Phe Thr Gln 
        275                 280                 285             


Gln Asp Leu Glu Asp Gly Arg Leu Gly Leu Glu Val Gly Arg Pro Glu 
    290                 295                 300                 


Gly Arg Ala Pro Gly Pro Ala Gly Asp Ser Leu Thr Leu Glu Leu Trp 
305                 310                 315                 320 


Ala Gln Gly Val Pro Pro Ala Val Ala Ser Leu Asp Phe Ala Thr Glu 
                325                 330                 335     


Pro Tyr Asn Ala Ala Arg Pro Tyr Ser Val Ala Leu Leu Ser Val Pro 
            340                 345                 350         


Glu Ala Ala Arg Thr Glu Ala Gly Lys Pro Glu Ser Ser Thr Pro Thr 
        355                 360                 365             


Gly Glu Pro Gly Pro Met Ala Ser Ser Pro Glu Pro Ala Val Ala Lys 
    370                 375                 380                 


Gly Gly Phe Leu Ser Phe Leu Glu Ala Asn Met Phe Ser Val Ile Ile 
385                 390                 395                 400 


Pro Met Cys Leu Val Leu Leu Leu Leu Ala Leu Ile Leu Pro Leu Leu 
                405                 410                 415     


Phe Tyr Leu 
            


<210>  7
<211>  545
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Domain
<222>  (524)..(545)
<223>  Transmembrane Domain

<400>  7

Gln His Pro Ser His Leu Trp Lys Asn Lys Gly Leu Trp Val Pro Glu 
1               5                   10                  15      


Gly Gln Arg Ala Arg Ile Thr Val Ala Ala Leu Asp Ala Ser Asn Leu 
            20                  25                  30          


Leu Ala Ser Val Pro Ser Pro Gln Arg Ser Glu His Asp Val Leu Phe 
        35                  40                  45              


Gln Val Thr Gln Phe Pro Ser Arg Gly Gln Leu Leu Val Ser Glu Glu 
    50                  55                  60                  


Pro Leu His Ala Gly Gln Pro His Phe Leu Gln Ser Gln Leu Ala Ala 
65                  70                  75                  80  


Gly Gln Leu Val Tyr Ala His Gly Gly Gly Gly Thr Gln Gln Asp Gly 
                85                  90                  95      


Phe His Phe Arg Ala His Leu Gln Gly Pro Ala Gly Ala Ser Val Ala 
            100                 105                 110         


Gly Pro Gln Thr Ser Glu Ala Phe Ala Ile Thr Val Arg Asp Val Asn 
        115                 120                 125             


Glu Arg Pro Pro Gln Pro Gln Ala Ser Val Pro Leu Arg Leu Thr Arg 
    130                 135                 140                 


Gly Ser Arg Ala Pro Ile Ser Arg Ala Gln Leu Ser Val Val Asp Pro 
145                 150                 155                 160 


Asp Ser Ala Pro Gly Glu Ile Glu Tyr Glu Val Gln Arg Ala Pro His 
                165                 170                 175     


Asn Gly Phe Leu Ser Leu Val Gly Gly Gly Leu Gly Pro Val Thr Arg 
            180                 185                 190         


Phe Thr Gln Ala Asp Val Asp Ser Gly Arg Leu Ala Phe Val Ala Asn 
        195                 200                 205             


Gly Ser Ser Val Ala Gly Ile Phe Gln Leu Ser Met Ser Asp Gly Ala 
    210                 215                 220                 


Ser Pro Pro Leu Pro Met Ser Leu Ala Val Asp Ile Leu Pro Ser Ala 
225                 230                 235                 240 


Ile Glu Val Gln Leu Arg Ala Pro Leu Glu Val Pro Gln Ala Leu Gly 
                245                 250                 255     


Arg Ser Ser Leu Ser Gln Gln Gln Leu Arg Val Val Ser Asp Arg Glu 
            260                 265                 270         


Glu Pro Glu Ala Ala Tyr Arg Leu Ile Gln Gly Pro Gln Tyr Gly His 
        275                 280                 285             


Leu Leu Val Gly Gly Arg Pro Thr Ser Ala Phe Ser Gln Phe Gln Ile 
    290                 295                 300                 


Asp Gln Gly Glu Val Val Phe Ala Phe Thr Asn Phe Ser Ser Ser His 
305                 310                 315                 320 


Asp His Phe Arg Val Leu Ala Leu Ala Arg Gly Val Asn Ala Ser Ala 
                325                 330                 335     


Val Val Asn Val Thr Val Arg Ala Leu Leu His Val Trp Ala Gly Gly 
            340                 345                 350         


Pro Trp Pro Gln Gly Ala Thr Leu Arg Leu Asp Pro Thr Val Leu Asp 
        355                 360                 365             


Ala Gly Glu Leu Ala Asn Arg Thr Gly Ser Val Pro Arg Phe Arg Leu 
    370                 375                 380                 


Leu Glu Gly Pro Arg His Gly Arg Val Val Arg Val Pro Arg Ala Arg 
385                 390                 395                 400 


Thr Glu Pro Gly Gly Ser Gln Leu Val Glu Gln Phe Thr Gln Gln Asp 
                405                 410                 415     


Leu Glu Asp Gly Arg Leu Gly Leu Glu Val Gly Arg Pro Glu Gly Arg 
            420                 425                 430         


Ala Pro Gly Pro Ala Gly Asp Ser Leu Thr Leu Glu Leu Trp Ala Gln 
        435                 440                 445             


Gly Val Pro Pro Ala Val Ala Ser Leu Asp Phe Ala Thr Glu Pro Tyr 
    450                 455                 460                 


Asn Ala Ala Arg Pro Tyr Ser Val Ala Leu Leu Ser Val Pro Glu Ala 
465                 470                 475                 480 


Ala Arg Thr Glu Ala Gly Lys Pro Glu Ser Ser Thr Pro Thr Gly Glu 
                485                 490                 495     


Pro Gly Pro Met Ala Ser Ser Pro Glu Pro Ala Val Ala Lys Gly Gly 
            500                 505                 510         


Phe Leu Ser Phe Leu Glu Ala Asn Met Phe Ser Val Ile Ile Pro Met 
        515                 520                 525             


Cys Leu Val Leu Leu Leu Leu Ala Leu Ile Leu Pro Leu Leu Phe Tyr 
    530                 535                 540                 


Leu 
545 


<210>  8
<211>  643
<212>  PRT
<213>  Cynomologus

<400>  8

Leu Ser Leu Glu Gly Ser Arg Thr Leu Thr Val Cys Pro Gly Ser Val 
1               5                   10                  15      


Gln Pro Leu Ser Ser Gln Thr Leu Arg Ala Ser Ser Ser Ala Gly Thr 
            20                  25                  30          


Asp Pro Gln Leu Leu Leu Tyr Arg Val Val Arg Gly Pro Gln Leu Gly 
        35                  40                  45              


Arg Leu Phe His Ala Gln Gln Asp Ser Thr Gly Glu Ala Leu Val Asn 
    50                  55                  60                  


Phe Thr Gln Ala Glu Val Tyr Ala Gly Asn Ile Leu Tyr Glu His Glu 
65                  70                  75                  80  


Met Pro Thr Glu Pro Phe Trp Glu Ala His Asp Thr Leu Glu Leu Gln 
                85                  90                  95      


Leu Ser Ser Pro Pro Ala Arg Asp Val Ala Ala Thr Leu Ala Val Ala 
            100                 105                 110         


Val Ser Phe Glu Ala Ala Cys Pro Gln Arg Pro Ser His Leu Trp Lys 
        115                 120                 125             


Asn Lys Gly Leu Trp Val Pro Glu Gly Gln Arg Ala Lys Ile Thr Met 
    130                 135                 140                 


Ala Ala Leu Asp Ala Ser Asn Leu Leu Ala Ser Val Pro Ser Pro Gln 
145                 150                 155                 160 


Arg Leu Glu His Asp Val Leu Phe Gln Val Thr Gln Phe Pro Ser Arg 
                165                 170                 175     


Gly Gln Leu Leu Val Ser Glu Glu Pro Leu His Ala Gly Gln Pro His 
            180                 185                 190         


Phe Leu Gln Ser Gln Leu Ala Ala Gly Gln Leu Val Tyr Ala His Gly 
        195                 200                 205             


Gly Gly Gly Thr Gln Gln Asp Gly Phe His Phe Arg Ala His Leu Gln 
    210                 215                 220                 


Gly Pro Ala Gly Ala Thr Val Ala Gly Pro Gln Thr Ser Glu Ala Phe 
225                 230                 235                 240 


Ala Ile Thr Val Arg Asp Val Asn Glu Arg Pro Pro Gln Pro Gln Ala 
                245                 250                 255     


Ser Val Pro Leu Arg Ile Thr Arg Gly Ser Arg Ala Pro Ile Ser Arg 
            260                 265                 270         


Ala Gln Leu Ser Val Val Asp Pro Asp Ser Ala Pro Gly Glu Ile Glu 
        275                 280                 285             


Tyr Glu Val Gln Arg Ala Pro His Asn Gly Phe Leu Ser Leu Val Gly 
    290                 295                 300                 


Gly Gly Pro Gly Pro Val Thr His Phe Thr Gln Ala Asp Val Asp Ser 
305                 310                 315                 320 


Gly Arg Leu Ala Phe Val Ala Asn Gly Ser Ser Val Ala Gly Val Phe 
                325                 330                 335     


Gln Leu Ser Met Ser Asp Gly Ala Ser Pro Pro Leu Pro Met Ser Leu 
            340                 345                 350         


Ala Val Asp Ile Leu Pro Ser Ala Ile Glu Val Gln Leu Gln Ala Pro 
        355                 360                 365             


Leu Glu Val Pro Gln Ala Leu Gly Arg Ser Ser Leu Ser Gln Gln Gln 
    370                 375                 380                 


Leu Arg Val Val Ser Asp Arg Glu Glu Pro Glu Ala Ala Tyr Arg Leu 
385                 390                 395                 400 


Ile Gln Gly Pro Lys Tyr Gly His Leu Leu Val Gly Gly Arg Pro Ala 
                405                 410                 415     


Ser Ala Phe Ser Gln Leu Gln Ile Asp Gln Gly Glu Val Val Phe Ala 
            420                 425                 430         


Phe Thr Asn Phe Ser Ser Ser His Asp His Phe Arg Val Leu Ala Leu 
        435                 440                 445             


Ala Arg Gly Val Asn Ala Ser Ala Val Val Asn Ile Thr Val Arg Ala 
    450                 455                 460                 


Leu Leu His Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Ala Thr Leu 
465                 470                 475                 480 


Arg Leu Asp Pro Thr Ile Leu Asp Ala Gly Glu Leu Ala Asn Arg Thr 
                485                 490                 495     


Gly Ser Val Pro His Phe Arg Leu Leu Glu Gly Pro Arg His Gly Arg 
            500                 505                 510         


Val Val Arg Val Pro Arg Ala Arg Thr Glu Pro Gly Gly Ser Gln Leu 
        515                 520                 525             


Val Glu Gln Phe Thr Gln Gln Asp Leu Glu Asp Gly Arg Leu Gly Leu 
    530                 535                 540                 


Glu Val Gly Arg Pro Glu Gly Arg Ala Pro Ser Pro Thr Gly Asp Ser 
545                 550                 555                 560 


Leu Thr Leu Glu Leu Trp Ala Gln Gly Val Pro Pro Ala Val Ala Ser 
                565                 570                 575     


Leu Asp Phe Ala Thr Glu Pro Tyr Asn Ala Ala Arg Pro Tyr Ser Val 
            580                 585                 590         


Ala Leu Leu Ser Val Pro Glu Ala Thr Arg Met Glu Ala Gly Lys Pro 
        595                 600                 605             


Glu Ser Ser Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser Ser Pro 
    610                 615                 620                 


Val Pro Ala Val Ala Lys Gly Gly Phe Leu Gly Phe Leu Glu Ala Asn 
625                 630                 635                 640 


Met Phe Ser 
            


<210>  9
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Ser Leu Lys Gly Ser Gln Thr Leu Thr Val Cys Pro Gly Ser Val 
1               5                   10                  15      


Gln Pro Leu Ser Ser Gln Thr Leu Arg Ala Ser Ser Ser Ala Gly Thr 
            20                  25                  30          


Asp Pro Gln Leu Leu Leu Tyr Arg Val Val Arg Gly Pro Gln Leu Gly 
        35                  40                  45              


Arg Leu Phe His Ala Gln Gln Asp Ser Thr Gly Glu Ala Leu Val Asn 
    50                  55                  60                  


Phe Thr Gln Ala Glu Val Tyr Ala Gly Asn Ile Leu Tyr Glu His Glu 
65                  70                  75                  80  


Met Pro Pro Glu Pro Phe Trp Glu Ala His Asp Thr Leu Glu Leu Gln 
                85                  90                  95      


Leu Ser Ser Pro Pro Ala Arg Asp Val Ala Ala Thr Leu Ala Val Ala 
            100                 105                 110         


Val Ser Phe Glu Ala Ala Cys Pro Gln His Pro Ser His Leu Trp Lys 
        115                 120                 125             


Asn Lys Gly Leu Trp Val Pro Glu Gly Gln Arg Ala Arg Ile Thr Val 
    130                 135                 140                 


Ala Ala Leu Asp Ala Ser Asn Leu Leu Ala Ser Val Pro Ser Pro Gln 
145                 150                 155                 160 


Arg Ser Glu His Asp Val Leu Phe Gln Val Thr Gln Phe Pro Ser Arg 
                165                 170                 175     


Gly Gln Leu Leu Val Ser Glu Glu Pro Leu His Ala Gly Gln Pro His 
            180                 185                 190         


Phe Leu Gln Ser Gln Leu Ala Ala Gly Gln Leu Val Tyr Ala His Gly 
        195                 200                 205             


Gly Gly Gly Thr Gln Gln Asp Gly Phe His Phe Arg Ala His Leu Gln 
    210                 215                 220                 


Gly Pro Ala Gly Ala Ser Val Ala Gly Pro Gln Thr Ser Glu Ala Phe 
225                 230                 235                 240 


Ala Ile Thr Val Arg Asp Val Asn Glu Arg Pro Pro Gln Pro Gln Ala 
                245                 250                 255     


Ser Val Pro Leu Arg Leu Thr Arg Gly Ser Arg Ala Pro Ile Ser Arg 
            260                 265                 270         


Ala Gln Leu Ser Val Val Asp Pro Asp Ser Ala Pro Gly Glu Ile Glu 
        275                 280                 285             


Tyr Glu Val Gln Arg Ala Pro His Asn Gly Phe Leu Ser Leu Val Gly 
    290                 295                 300                 


Gly Gly Leu Gly Pro Val Thr Arg Phe Thr Gln Ala Asp Val Asp Ser 
305                 310                 315                 320 


Gly Arg Leu Ala Phe Val Ala Asn Gly Ser Ser Val Ala Gly Ile Phe 
                325                 330                 335     


Gln Leu Ser Met Ser Asp Gly Ala Ser Pro Pro Leu Pro Met Ser Leu 
            340                 345                 350         


Ala Val Asp Ile Leu Pro Ser Ala Ile Glu Val Gln Leu Arg Ala Pro 
        355                 360                 365             


Leu Glu Val Pro Gln Ala Leu Gly Arg Ser Ser Leu Ser Gln Gln Gln 
    370                 375                 380                 


Leu Arg Val Val Ser Asp Arg Glu Glu Pro Glu Ala Ala Tyr Arg Leu 
385                 390                 395                 400 


Ile Gln Gly Pro Gln Tyr Gly His Leu Leu Val Gly Gly Arg Pro Thr 
                405                 410                 415     


Ser Ala Phe Ser Gln Phe Gln Ile Asp Gln Gly Glu Val Val Phe Ala 
            420                 425                 430         


Phe Thr Asn Phe Ser Ser Ser His Asp His Phe Arg Val Leu Ala Leu 
        435                 440                 445             


Ala Arg Gly Val Asn Ala Ser Ala Val Val Asn Val Thr Val Arg Ala 
    450                 455                 460                 


Leu Leu His Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Ala Thr Leu 
465                 470                 475                 480 


Arg Leu Asp Pro Thr Val Leu Asp Ala Gly Glu Leu Ala Asn Arg Thr 
                485                 490                 495     


Gly Ser Val Pro Arg Phe Arg Leu Leu Glu Gly Pro Arg His Gly Arg 
            500                 505                 510         


Val Val Arg Val Pro Arg Ala Arg Thr Glu Pro Gly Gly Ser Gln Leu 
        515                 520                 525             


Val Glu Gln Phe Thr Gln Gln Asp Leu Glu Asp Gly Arg Leu Gly Leu 
    530                 535                 540                 


Glu Val Gly Arg Pro Glu Gly Arg Ala Pro Gly Pro Ala Gly Asp Ser 
545                 550                 555                 560 


Leu Thr Leu Glu Leu Trp Ala Gln Gly Val Pro Pro Ala Val Ala Ser 
                565                 570                 575     


Leu Asp Phe Ala Thr Glu Pro Tyr Asn Ala Ala Arg Pro Tyr Ser Val 
            580                 585                 590         


Ala Leu Leu Ser Val Pro Glu Ala Ala Arg Thr Glu Ala Gly Lys Pro 
        595                 600                 605             


Glu Ser Ser Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser Ser Pro 
    610                 615                 620                 


Glu Pro Ala Val Ala Lys Gly Gly Phe Leu Ser Phe Leu Glu Ala Asn 
625                 630                 635                 640 


Met Phe Ser 
            


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-L1

<400>  10

Ser Ala Ser Gln Gly Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2

<400>  11

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-L3

<400>  12

Gln Gln Tyr Ser Lys Leu Pro Trp Thr 
1               5                   


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1

<400>  13

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-H1

<400>  14

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr Trp Asn 
1               5                   10      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-H2

<400>  15

Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-H3

<400>  16

Phe Asp Tyr 
1           


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-H1

<400>  17

Gly Gly Ser Ile Thr Ser Gly Tyr Tyr Trp Asn 
1               5                   10      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-H2

<400>  18

Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-L1

<400>  19

Ser Ala Ser Gln Ser Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1

<400>  20

Ser Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-L1

<400>  21

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2

<400>  22

Tyr Thr Ser Ser Leu Gln Ser 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-L2

<400>  23

Asp Ala Ser Ser Leu His Ser 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-L2

<400>  24

Tyr Thr Ser Asn Leu Glu Thr 
1               5           


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HVR-H1

<400>  25

Ser Gly Tyr Tyr Trp Ser 
1               5       


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LC007 Chimeric Antibody VL

<400>  26

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LC007 Chimeric Antibody VH

<400>  27

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LC007 Humanized Antibody ML1 VL

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  29
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LC007 Humanized Antibody M4-1 VH

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LC007 Humanized Antibody M4-2 VH

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  31
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LC007 Humanized Antibody ML2 VL

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  32
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LC007 Humanized Antibody M4-3 VH

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  33
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LC007 Humanized Antibody M4-6 VH

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  34
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007  Chimeric Antibody Light Chain

<400>  34

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  35
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007  Chimeric Antibody Heavy Chain

<400>  35

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  36
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 Humanized Antibody ML2 Light Chain

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  37
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC007 Humanized Antibody M4-3 Heavy Chain

<400>  37

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  38
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 Murine Antibody Light Chain

<400>  38
gatattgtgc tcacacagtc tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattaga aattatttaa actggtatca gcagagacca      120

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  39
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 Murine Antibody Heavy Chain

<400>  39
gaggtccagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaagctgga atggatgggc tacataacct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc ggactttgac      300

tactggggcc aaggcaccac tctcacagtc tcctcagcc                             339


<210>  40
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 Chimeric Antibody Light Chain

<400>  40
gatattgtgc tcacacagtc tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca gggcattaga aattatttaa actggtatca gcagagacca      120

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tatagtaagc ttccttggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  41
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 Chimeric Antibody Heavy Chain

<400>  41
gaggtccagc tgcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaagctgga atggatgggc tacataacct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagctacat attactgtgc ggactttgac      300

tactggggcc aaggcaccac tctcacagtc tcctcagcta gcaccaaggg cccatcggtc      360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      480

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      600

cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaatga                                                             1329


<210>  42
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 Humanized Antibody  ML2 Light Chain

<400>  42
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgcc gggccagcca gggcatccgg aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcagcc tgcacagcgg cgtgcctagc      180

cggtttagcg gcagcggctc cggcaccgac ttcaccctga ccattagctc cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacagcaagc tgccctggac cttcggccag      300

ggaacaaagg tggagatcaa g                                                321


<210>  43
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC007 Humanized Antibody  M4-3 Heavy Chain

<400>  43
caggtgcagc tgcaggaaag cggccctggc ctggtcaagc ccagccagac cctgagcctg       60

acctgcaccg tgtccggcgg cagcatcacc agcggctact actggaactg gatccggcag      120

caccccggca agggcctgga atggatcggc tacatcacct acgacggcag caacaactac      180

aaccccagcc tgaagtccag agtgaccatc agccgggaca ccagcaagaa ccagttcagc      240

ctgaagctgt ccagcgtgac agccgccgac accgccgtgt actactgcgc cgacttcgac      300

tactggggcc agggcaccct ggtcaccgtg tccagc                                336


<210>  44
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  44

Val Ile Ile Pro Met Cys Leu Val Leu Leu Leu Leu Ala Leu Ile Leu 
1               5                   10                  15      


Pro Leu Leu Phe Tyr 
            20      


