                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  Novel immunomodulatory peptide

<130>  P2659PC00

<150>  EP 11178133.2
<151>  2011-08-19

<150>  US 61/559,818
<151>  2011-11-15

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ile Gly Asp Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His 
1               5                   10                  15      


Pro Val Phe Cys Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu 
            20                  25                  30          


Pro Gly Thr Lys Cys Cys Lys Lys Pro 
        35                  40      


<210>  2
<211>  41
<212>  PRT
<213>  Macaca mulatta

<400>  2

Gly Ile Gly Asp Pro Val Thr Cys Leu Lys Asn Gly Ala Ile Cys His 
1               5                   10                  15      


Pro Val Phe Cys Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu 
            20                  25                  30          


Pro Gly Thr Lys Cys Cys Lys Lys Pro 
        35                  40      


<210>  3
<211>  41
<212>  PRT
<213>  Pan troglodytes

<400>  3

Gly Ile Ser Asp Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His 
1               5                   10                  15      


Pro Val Phe Cys Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu 
            20                  25                  30          


Pro Gly Thr Lys Cys Cys Lys Lys Pro 
        35                  40      


<210>  4
<211>  44
<212>  PRT
<213>  Pongo pygmaeus

<400>  4

Val Phe Gly Asp Ile Ser Asn Pro Val Thr Cys Leu Arg Ser Gly Ala 
1               5                   10                  15      


Ile Cys His Pro Gly Phe Cys Pro Arg Arg Tyr Lys His Ile Gly Thr 
            20                  25                  30          


Cys Gly Leu Ser Val Ile Lys Cys Cys Lys Lys Pro 
        35                  40                  


<210>  5
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(37)
<223>  N-terminally truncated hBD2

<400>  5

Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His Pro Val Phe Cys 
1               5                   10                  15      


Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr Lys 
            20                  25                  30          


Cys Cys Lys Lys Pro 
        35          


<210>  6
<211>  37
<212>  PRT
<213>  Macaca mulatta


<220>
<221>  MISC_FEATURE
<222>  (1)..(37)
<223>  N-terminally truncated rhesus macaque BD2

<400>  6

Pro Val Thr Cys Leu Lys Asn Gly Ala Ile Cys His Pro Val Phe Cys 
1               5                   10                  15      


Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr Lys 
            20                  25                  30          


Cys Cys Lys Lys Pro 
        35          


<210>  7
<211>  37
<212>  PRT
<213>  Pan troglodytes


<220>
<221>  MISC_FEATURE
<222>  (1)..(37)
<223>  N-terminally truncated chimpanzee BD2

<400>  7

Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His Pro Val Phe Cys 
1               5                   10                  15      


Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr Lys 
            20                  25                  30          


Cys Cys Lys Lys Pro 
        35          


<210>  8
<211>  37
<212>  PRT
<213>  Pan troglodytes


<220>
<221>  MISC_FEATURE
<222>  (1)..(37)
<223>  N-terminally truncated orangutan BD2

<400>  8

Pro Val Thr Cys Leu Arg Ser Gly Ala Ile Cys His Pro Gly Phe Cys 
1               5                   10                  15      


Pro Arg Arg Tyr Lys His Ile Gly Thr Cys Gly Leu Ser Val Ile Lys 
            20                  25                  30          


Cys Cys Lys Lys Pro 
        35          


<210>  9
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(38)
<223>  Cleaved hBD2 variant (SEQ ID NO 5 + 1 N-terminal AA)

<400>  9

Asp Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His Pro Val Phe 
1               5                   10                  15      


Cys Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr 
            20                  25                  30          


Lys Cys Cys Lys Lys Pro 
        35              


<210>  10
<211>  39
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(39)
<223>  Cleaved hBD2 variant (SEQ ID NO 5 + 2 N-terminal AA)

<400>  10

Gly Asp Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His Pro Val 
1               5                   10                  15      


Phe Cys Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu Pro Gly 
            20                  25                  30          


Thr Lys Cys Cys Lys Lys Pro 
        35                  


<210>  11
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(40)
<223>  Cleaved hBD2 variant (SEQ ID NO 5 + 3 N-terminal AA)

<400>  11

Ile Gly Asp Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His Pro 
1               5                   10                  15      


Val Phe Cys Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu Pro 
            20                  25                  30          


Gly Thr Lys Cys Cys Lys Lys Pro 
        35                  40  


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal variant

<400>  12

Ile Gly Asp Pro Val Thr 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal variant

<400>  13

Gly Asp Pro Val Thr Cys 
1               5       


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal variant

<400>  14

Asp Pro Val Thr Cys 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal variant

<400>  15

Pro Val Thr Cys Leu 
1               5   


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal variant

<400>  16

Pro Val Thr Cys Leu Lys 
1               5       


<210>  17
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence 1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa=K or R

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=S or N

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa=V or G

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa=Q or H

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa=P or S

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa=G or V

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa=T or I

<400>  17

Xaa Xaa Gly Ala Ile Cys His Pro Xaa Phe Cys Pro Arg Arg Tyr Lys 
1               5                   10                  15      


Xaa Ile Gly Thr Cys Gly Leu Xaa Xaa Xaa Lys Cys Cys Lys Pro 
            20                  25                  30      


<210>  18
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P V T C L X1 X2 G A I C H P X3 F C P R R Y K X4 I G T C G L X5 X6
       X7 K C C K K P


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa=K or R

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa=S or N

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa=V or G

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa=Q or H

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa=P or S

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa=G or V

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa=T or I

<400>  18

Pro Val Thr Cys Leu Xaa Xaa Gly Ala Ile Cys His Pro Xaa Phe Cys 
1               5                   10                  15      


Pro Arg Arg Tyr Lys Xaa Ile Gly Thr Cys Gly Leu Xaa Xaa Xaa Lys 
            20                  25                  30          


Cys Cys Lys Lys Pro 
        35          


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncation

<400>  19

Gly Ile Gly Asp 
1               


