                         SEQUENCE LISTING

<110>  GlobeImmune, Inc.
       THE UNITED STATES OF AMERICA, Department of Health & Human 
       Services
       Franzusoff, Alex
       Guo, Zhimin
       Schlom, Jeffrey
       Tsang, Kwong-Yok
 
<120>  Yeast-MUC1 Immunotherapeutic Compositions and Uses Thereof

<130>  3923-40-PCT

<150>  61/524,407
<151>  2011-08-17

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  1209
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (67)..(888)

<400>  1
acctctcaag cagccagcgc ctgcctgaat ctgttctgcc ccctccccac ccatttcacc       60

accacc atg aca ccg ggc acc cag tct cct ttc ttc ctg ctg ctg ctc         108
       Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu            
       1               5                   10                             

ctc aca gtg ctt aca gtt gtt acg ggt tct ggt cat gca agc tct acc        156
Leu Thr Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr           
15                  20                  25                  30            

cca ggt gga gaa aag gag act tcg gct acc cag aga agt tca gtg ccc        204
Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro           
                35                  40                  45                

agc tct act gag aag aat gct ttg tct act ggg gtc tct ttc ttt ttc        252
Ser Ser Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe           
            50                  55                  60                    

ctg tct ttt cac att tca aac ctc cag ttt aat tcc tct ctg gaa gat        300
Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp           
        65                  70                  75                        

ccc agc acc gac tac tac caa gag ctg cag aga gac att tct gaa atg        348
Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met           
    80                  85                  90                            

ttt ttg cag att tat aaa caa ggg ggt ttt ctg ggc ctc tcc aat att        396
Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile           
95                  100                 105                 110           

aag ttc agg cca gga tct gtg gtg gta caa ttg act ctg gcc ttc cga        444
Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg           
                115                 120                 125               

gaa ggt acc atc aat gtc cac gac gtg gag aca cag ttc aat cag tat        492
Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr           
            130                 135                 140                   

aaa acg gaa gca gcc tct cga tat aac ctg acg atc tca gac gtc agc        540
Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser           
        145                 150                 155                       

gtg agt gat gtg cca ttt cct ttc tct gcc cag tct ggg gct ggg gtg        588
Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val           
    160                 165                 170                           

cca ggc tgg ggc atc gcg ctg ctg gtg ctg gtc tgt gtt ctg gtt gcg        636
Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala           
175                 180                 185                 190           

ctg gcc att gtc tat ctc att gcc ttg gct gtc tgt cag tgc cgc cga        684
Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg           
                195                 200                 205               

aag aac tac ggg cag ctg gac atc ttt cca gcc cgg gat acc tac cat        732
Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His           
            210                 215                 220                   

cct atg agc gag tac ccc acc tac cac acc cat ggg cgc tat gtg ccc        780
Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro           
        225                 230                 235                       

cct agc agt acc gat cgt agc ccc tat gag aag gtt tct gca ggt aat        828
Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn           
    240                 245                 250                           

ggt ggc agc agc ctc tct tac aca aac cca gca gtg gca gcc act tct        876
Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser           
255                 260                 265                 270           

gcc aac ttg tag gggcacgtcg cccgctgagc tgagtggcca gccagtgcca            928
Ala Asn Leu                                                               
                                                                          

ttccactcca ctcaggttct tcagggccag agcccctgca ccctgtttgg gctggtgagc      988

tgggagttca ggtgggctgc tcacagcctc cttcagaggc cccaccaatt tctcggacac     1048

ttctcagtgt gtggaagctc atgtgggccc ctgagggctc atgcctggga agtgttgtgg     1108

tgggggctcc caggaggact ggcccagaga gccctgagat agcggggatc ctgaactgga     1168

ctgaataaaa cgtggtctcc cactgcgcca aaaaaaaaaa a                         1209


<210>  2
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  3
<211>  1182
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (67)..(861)

<400>  3
acctctcaag cagccagcgc ctgcctgaat ctgttctgcc ccctccccac ccatttcacc       60

accacc atg aca ccg ggc acc cag tct cct ttc ttc ctg ctg ctg ctc         108
       Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu            
       1               5                   10                             

ctc aca gtg ctt aca gct acc aca gcc cct aaa ccc gca aca gtt gtt        156
Leu Thr Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val           
15                  20                  25                  30            

acg ggt tct ggt cat gca agc tct acc cca ggt gga gaa aag gag act        204
Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr           
                35                  40                  45                

tcg gct acc cag aga agt tca gtg ccc agc tct act gag aag aat gct        252
Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala           
            50                  55                  60                    

ttt aat tcc tct ctg gaa gat ccc agc acc gac tac tac caa gag ctg        300
Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu           
        65                  70                  75                        

cag aga gac att tct gaa atg ttt ttg cag att tat aaa caa ggg ggt        348
Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly           
    80                  85                  90                            

ttt ctg ggc ctc tcc aat att aag ttc agg cca gga tct gtg gtg gta        396
Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val           
95                  100                 105                 110           

caa ttg act ctg gcc ttc cga gaa ggt acc atc aat gtc cac gac gtg        444
Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val           
                115                 120                 125               

gag aca cag ttc aat cag tat aaa acg gaa gca gcc tct cga tat aac        492
Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn           
            130                 135                 140                   

ctg acg atc tca gac gtc agc gtg agt gat gtg cca ttt cct ttc tct        540
Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser           
        145                 150                 155                       

gcc cag tct ggg gct ggg gtg cca ggc tgg ggc atc gcg ctg ctg gtg        588
Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val           
    160                 165                 170                           

ctg gtc tgt gtt ctg gtt gcg ctg gcc att gtc tat ctc att gcc ttg        636
Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu           
175                 180                 185                 190           

gct gtc tgt cag tgc cgc cga aag aac tac ggg cag ctg gac atc ttt        684
Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe           
                195                 200                 205               

cca gcc cgg gat acc tac cat cct atg agc gag tac ccc acc tac cac        732
Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His           
            210                 215                 220                   

acc cat ggg cgc tat gtg ccc cct agc agt acc gat cgt agc ccc tat        780
Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr           
        225                 230                 235                       

gag aag gtt tct gca ggt aat ggt ggc agc agc ctc tct tac aca aac        828
Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn           
    240                 245                 250                           

cca gca gtg gca gcc act tct gcc aac ttg tag gggcacgtcg cccgctgagc      881
Pro Ala Val Ala Ala Thr Ser Ala Asn Leu                                   
255                 260                                                   

tgagtggcca gccagtgcca ttccactcca ctcaggttct tcagggccag agcccctgca      941

ccctgtttgg gctggtgagc tgggagttca ggtgggctgc tcacagcctc cttcagaggc     1001

cccaccaatt tctcggacac ttctcagtgt gtggaagctc atgtgggccc ctgagggctc     1061

atgcctggga agtgttgtgg tgggggctcc caggaggact ggcccagaga gccctgagat     1121

agcggggatc ctgaactgga ctgaataaaa cgtggtctcc cactgcgcca aaaaaaaaaa     1181

a                                                                     1182


<210>  4
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
145                 150                 155                 160 


Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
                165                 170                 175     


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
            180                 185                 190         


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
        195                 200                 205             


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
    210                 215                 220                 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
225                 230                 235                 240 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
                245                 250                 255     


Val Ala Ala Thr Ser Ala Asn Leu 
            260                 


<210>  5
<211>  1032
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (51)..(845)

<400>  5
gcgcctgcct gaatctgttc tgccccctcc ccacccattt caccaccacc atg aca          56
                                                       Met Thr            
                                                       1                  

ccg ggc acc cag tct cct ttc ttc ctg ctg ctg ctc ctc aca gtg ctt        104
Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr Val Leu           
        5                   10                  15                        

aca gct acc aca gcc cct aaa ccc gca aca gtt gtt aca ggt tct ggt        152
Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly Ser Gly           
    20                  25                  30                            

cat gca agc tct acc cca ggt gga gaa aag gag act tcg gct acc cag        200
His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln           
35                  40                  45                  50            

aga agt tca gtg ccc agc tct act gag aag aat gct ttt aat tcc tct        248
Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn Ser Ser           
                55                  60                  65                

ctg gaa gat ccc agc acc gac tac tac caa gag ctg cag aga gac att        296
Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile           
            70                  75                  80                    

tct gaa atg ttt ttg cag att tat aaa caa ggg ggt ttt ctg ggc ctc        344
Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu           
        85                  90                  95                        

tcc aat att aag ttc agg cca gga tct gtg gtg gta caa ttg act ctg        392
Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu           
    100                 105                 110                           

gcc ttc cga gaa ggt acc atc aat gtc cac gac atg gag aca cag ttc        440
Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Met Glu Thr Gln Phe           
115                 120                 125                 130           

aat cag tat aaa acg gaa gca gcc tct cga tat aac ctg acg atc tca        488
Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser           
                135                 140                 145               

gac gtc agc gtg agt ggt gtg cca ttt cct ttc tct gcc cag tct ggg        536
Asp Val Ser Val Ser Gly Val Pro Phe Pro Phe Ser Ala Gln Ser Gly           
            150                 155                 160                   

gct ggg gtg cca ggc tgg ggc atc gcg ctg ctg gtg ctg gtc tgt gtt        584
Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val           
        165                 170                 175                       

ctg gtt gcg ctg gcc att gtc tat ctc att gcc ttg gct gtc tgt cag        632
Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln           
    180                 185                 190                           

tgc cgc cga aag aac tac ggg cag ctg gac atc ttt cca gcc cgg gat        680
Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp           
195                 200                 205                 210           

acc tac cat cct atg agc gag tac ccc acc tac cac acc cat ggg cgc        728
Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg           
                215                 220                 225               

tat gtg ccc cct agc agt acc gat cgt agc ccc tat gag aag gtt tct        776
Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser           
            230                 235                 240                   

gca ggt aat ggt ggc agc agc ctc tct tac aca aac cca gca gtg gca        824
Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala           
        245                 250                 255                       

gcc act tct gcc aac ttg tag gggcacgtcg cccgctgagc tgagtggcca           875
Ala Thr Ser Ala Asn Leu                                                   
    260                                                                   

gccagtgcca ttccactcca ctcaggttct tcagggccag agcccctgca ccctgtttgg      935

gctggtgagc tgggagttca ggtgggctgc tcacagcctc cttcagaggc cccaccaatt      995

tctcggacac ttctcagtgt gtggaagctc atgtggg                              1032


<210>  6
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Met Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Ser Gly Val Pro Phe Pro Phe Ser Ala Gln 
145                 150                 155                 160 


Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
                165                 170                 175     


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
            180                 185                 190         


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
        195                 200                 205             


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
    210                 215                 220                 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
225                 230                 235                 240 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
                245                 250                 255     


Val Ala Ala Thr Ser Ala Asn Leu 
            260                 


<210>  7
<211>  1166
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (73)..(840)

<400>  7
cgctccacct ctcaagcagc cagcgcctgc ctgaatctgt tctgccccct ccccacccat       60

ttcaccacca cc atg aca ccg ggc acc cag tct cct ttc ttc ctg ctg ctg      111
              Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu         
              1               5                   10                      

ctc ctc aca gtg ctt aca gtt gtt acg ggt tct ggt cat gca agc tct        159
Leu Leu Thr Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser           
    15                  20                  25                            

acc cca ggt gga gaa aag gag act tcg gct acc cag aga agt tca gtg        207
Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val           
30                  35                  40                  45            

ccc agc tct act gag aag aat gct ttt aat tcc tct ctg gaa gat ccc        255
Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro           
                50                  55                  60                

agc acc gac tac tac caa gag ctg cag aga gac att tct gaa atg ttt        303
Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe           
            65                  70                  75                    

ttg cag att tat aaa caa ggg ggt ttt ctg ggc ctc tcc aat att aag        351
Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys           
        80                  85                  90                        

ttc agg cca gga tct gtg gtg gta caa ttg act ctg gcc ttc cga gaa        399
Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu           
    95                  100                 105                           

ggt acc atc aat gtc cac gac gtg gag aca cag ttc aat cag tat aaa        447
Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys           
110                 115                 120                 125           

acg gaa gca gcc tct cga tat aac ctg acg atc tca gac gtc agc gtg        495
Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val           
                130                 135                 140               

agt gat gtg cca ttt cct ttc tct gcc cag tct ggg gct ggg gtg cca        543
Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro           
            145                 150                 155                   

ggc tgg ggc atc gcg ctg ctg gtg ctg gtc tgt gtt ctg gtt gcg ctg        591
Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu           
        160                 165                 170                       

gcc att gtc tat ctc att gcc ttg gct gtc tgt cag tgc cgc cga aag        639
Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys           
    175                 180                 185                           

aac tac ggg cag ctg gac atc ttt cca gcc cgg gat acc tac cat cct        687
Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro           
190                 195                 200                 205           

atg agc gag tac ccc acc tac cac acc cat ggg cgc tat gtg ccc cct        735
Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro           
                210                 215                 220               

agc agt acc gat cgt agc ccc tat gag aag gtt tct gca ggt aat ggt        783
Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly           
            225                 230                 235                   

ggc agc agc ctc tct tac aca aac cca gca gtg gca gcc act tct gcc        831
Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala           
        240                 245                 250                       

aac ttg tag gggcacgtcg cccgctgagc tgagtggcca gccagtgcca                880
Asn Leu                                                                   
    255                                                                   

ttccactcca ctcaggttct tcagggccag agcccctgca ccctgtttgg gctggtgagc      940

tgggagttca ggtgggctgc tcacagcctc cttcagaggc cccaccaatt tctcggacac     1000

ttctcagtgt gtggaagctc atgtgggccc ctgagggctc atgcctggga agtgttgtgg     1060

tgggggctcc caggaggact ggcccagaga gccctgagat agcggggatc ctgaactgga     1120

ctgaataaaa cgtggtctcc cactgcgcca aaaaaaaaaa aaaaaa                    1166


<210>  8
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro 
                85                  90                  95      


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
            100                 105                 110         


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
        115                 120                 125             


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
    130                 135                 140                 


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
145                 150                 155                 160 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
                165                 170                 175     


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
            180                 185                 190         


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
        195                 200                 205             


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
    210                 215                 220                 


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
225                 230                 235                 240 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
                245                 250                 255 


<210>  9
<211>  2235
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (69)..(1964)

<400>  9
ccacctcaca cacggagcgc cagccttgag tttgttttct agccccttcc cgcctgttca       60

ccaccacc atg acc ccg ggc att cgg gct cct ttc ttc ctg ctg cta ctt       110
         Met Thr Pro Gly Ile Arg Ala Pro Phe Phe Leu Leu Leu Leu          
         1               5                   10                           

cta gca agt cta aaa ggt ttt ctt gcc ctt cca agt gag gaa aac agt        158
Leu Ala Ser Leu Lys Gly Phe Leu Ala Leu Pro Ser Glu Glu Asn Ser           
15                  20                  25                  30            

gtc acc tca tct cag gac acc agc agt tcc tta gca tcg act acc act        206
Val Thr Ser Ser Gln Asp Thr Ser Ser Ser Leu Ala Ser Thr Thr Thr           
                35                  40                  45                

cca gtc cac agc agc aac tca gac cca gcc acc aga cct cca ggg gac        254
Pro Val His Ser Ser Asn Ser Asp Pro Ala Thr Arg Pro Pro Gly Asp           
            50                  55                  60                    

tcc acc agc tct cca gtc cag agt agc acc tct tct cca gcc acc aga        302
Ser Thr Ser Ser Pro Val Gln Ser Ser Thr Ser Ser Pro Ala Thr Arg           
        65                  70                  75                        

gct cct gaa gac tct acc agt act gca gtc ctc agt ggc acc tcc tcc        350
Ala Pro Glu Asp Ser Thr Ser Thr Ala Val Leu Ser Gly Thr Ser Ser           
    80                  85                  90                            

cca gcc acc aca gct cca gtg aac tcc gcc agc tct cca gta gcc cat        398
Pro Ala Thr Thr Ala Pro Val Asn Ser Ala Ser Ser Pro Val Ala His           
95                  100                 105                 110           

ggt gac acc tct tcc cca gcc act agc ctt tca aaa gac tcc aac agc        446
Gly Asp Thr Ser Ser Pro Ala Thr Ser Leu Ser Lys Asp Ser Asn Ser           
                115                 120                 125               

tct cca gta gtc cac agt ggc acc tct tca gct ccg gcc acc aca gct        494
Ser Pro Val Val His Ser Gly Thr Ser Ser Ala Pro Ala Thr Thr Ala           
            130                 135                 140                   

cca gtg gat tcc acc agc tct cca gta gtc cac ggt ggt acc tcg tcc        542
Pro Val Asp Ser Thr Ser Ser Pro Val Val His Gly Gly Thr Ser Ser           
        145                 150                 155                       

cca gcc acc agc cct cca ggg gac tcc acc agc tct cca gac cat agt        590
Pro Ala Thr Ser Pro Pro Gly Asp Ser Thr Ser Ser Pro Asp His Ser           
    160                 165                 170                           

agc acc tct tct cca gcc acc aga gct ccc gaa gac tct acc agt act        638
Ser Thr Ser Ser Pro Ala Thr Arg Ala Pro Glu Asp Ser Thr Ser Thr           
175                 180                 185                 190           

gca gtc ctc agt ggc acc tcc tcc cca gcc acc aca gct cca gtg gac        686
Ala Val Leu Ser Gly Thr Ser Ser Pro Ala Thr Thr Ala Pro Val Asp           
                195                 200                 205               

tcc acc agc tct cca gta gcc cat gat gac acc tct tcc cca gcc act        734
Ser Thr Ser Ser Pro Val Ala His Asp Asp Thr Ser Ser Pro Ala Thr           
            210                 215                 220                   

agc ctt tca gaa gac tcc gcc agc tct cca gta gcc cac ggt ggc acc        782
Ser Leu Ser Glu Asp Ser Ala Ser Ser Pro Val Ala His Gly Gly Thr           
        225                 230                 235                       

tct tct cca gcc acc agc cct cta agg gac tcc acc agt tct cca gtc        830
Ser Ser Pro Ala Thr Ser Pro Leu Arg Asp Ser Thr Ser Ser Pro Val           
    240                 245                 250                           

cac agt agt gcc tcc atc caa aac atc aag act aca tca gac tta gct        878
His Ser Ser Ala Ser Ile Gln Asn Ile Lys Thr Thr Ser Asp Leu Ala           
255                 260                 265                 270           

agc act cca gac cac aat ggc acc tca gtc aca act acc agc tct gca        926
Ser Thr Pro Asp His Asn Gly Thr Ser Val Thr Thr Thr Ser Ser Ala           
                275                 280                 285               

ctg ggc tca gcc acc agt cca gac cac agt ggt acc tca act aca act        974
Leu Gly Ser Ala Thr Ser Pro Asp His Ser Gly Thr Ser Thr Thr Thr           
            290                 295                 300                   

aac agc tct gaa tca gtc ttg gcc acc act cca gtt tac agt agc atg       1022
Asn Ser Ser Glu Ser Val Leu Ala Thr Thr Pro Val Tyr Ser Ser Met           
        305                 310                 315                       

cca ttc tct act acc aaa gtg acg tca ggc tca gct atc att cca gac       1070
Pro Phe Ser Thr Thr Lys Val Thr Ser Gly Ser Ala Ile Ile Pro Asp           
    320                 325                 330                           

cac aat ggc tcc tcg gtg cta cct acc agt tct gtg ttg ggc tca gct       1118
His Asn Gly Ser Ser Val Leu Pro Thr Ser Ser Val Leu Gly Ser Ala           
335                 340                 345                 350           

acc agt cta gtc tat aat acc tct gca ata gct aca act cca gtc agc       1166
Thr Ser Leu Val Tyr Asn Thr Ser Ala Ile Ala Thr Thr Pro Val Ser           
                355                 360                 365               

aat ggc act cag cct tca gtg cca agt caa tac cct gtt tct cct acc       1214
Asn Gly Thr Gln Pro Ser Val Pro Ser Gln Tyr Pro Val Ser Pro Thr           
            370                 375                 380                   

atg gcc acc acc tcc agc cac agc act att gcc agc agc tct tac tat       1262
Met Ala Thr Thr Ser Ser His Ser Thr Ile Ala Ser Ser Ser Tyr Tyr           
        385                 390                 395                       

agc aca gta cca ttt tct acc ttc tcc agt aac agt tca ccc cag ttg       1310
Ser Thr Val Pro Phe Ser Thr Phe Ser Ser Asn Ser Ser Pro Gln Leu           
    400                 405                 410                           

tct gtt ggg gtc tcc ttc ttc ttc ttg tct ttt tac att caa aac cac       1358
Ser Val Gly Val Ser Phe Phe Phe Leu Ser Phe Tyr Ile Gln Asn His           
415                 420                 425                 430           

cca ttt aat tct tct ctg gaa gac ccc agc tcc aac tac tac caa gaa       1406
Pro Phe Asn Ser Ser Leu Glu Asp Pro Ser Ser Asn Tyr Tyr Gln Glu           
                435                 440                 445               

ctg aag agg aac att tct gga ttg ttt ctg cag att ttt aac gga gat       1454
Leu Lys Arg Asn Ile Ser Gly Leu Phe Leu Gln Ile Phe Asn Gly Asp           
            450                 455                 460                   

ttt ctg ggg atc tct agc atc aag ttc agg tca ggc tcc gtg gtg gta       1502
Phe Leu Gly Ile Ser Ser Ile Lys Phe Arg Ser Gly Ser Val Val Val           
        465                 470                 475                       

gaa tcg act gtg gtt ttc cgg gag ggt act ttt agt gcc tct gac gtg       1550
Glu Ser Thr Val Val Phe Arg Glu Gly Thr Phe Ser Ala Ser Asp Val           
    480                 485                 490                           

aag tca cag ctt ata cag cat aag aag gag gca gat gac tat aat ctg       1598
Lys Ser Gln Leu Ile Gln His Lys Lys Glu Ala Asp Asp Tyr Asn Leu           
495                 500                 505                 510           

act att tca gaa gtc aaa gtg aat gag atg cag ttc cct ccc tct gcc       1646
Thr Ile Ser Glu Val Lys Val Asn Glu Met Gln Phe Pro Pro Ser Ala           
                515                 520                 525               

cag tcc cgg ccg ggg gta cca ggc tgg ggc att gcc ctg ctg gtg ctg       1694
Gln Ser Arg Pro Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu           
            530                 535                 540                   

gtc tgt att ttg gtt gct ttg gct atc gtc tat ttc ctt gcc ctg gca       1742
Val Cys Ile Leu Val Ala Leu Ala Ile Val Tyr Phe Leu Ala Leu Ala           
        545                 550                 555                       

gtg tgc cag tgc cgc cga aag agc tat ggg cag ctg gac atc ttt cca       1790
Val Cys Gln Cys Arg Arg Lys Ser Tyr Gly Gln Leu Asp Ile Phe Pro           
    560                 565                 570                           

acc cag gac acc tac cat cct atg agt gaa tac cct acc tac cac act       1838
Thr Gln Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr           
575                 580                 585                 590           

cac gga cgc tac gtg ccc cct ggc agt acc aag cgt agc ccc tat gag       1886
His Gly Arg Tyr Val Pro Pro Gly Ser Thr Lys Arg Ser Pro Tyr Glu           
                595                 600                 605               

gag gtt tcg gca ggt aat ggc agt agc agt ctc tct tat acc aac cca       1934
Glu Val Ser Ala Gly Asn Gly Ser Ser Ser Leu Ser Tyr Thr Asn Pro           
            610                 615                 620                   

gct gtg gtg acc act tct gcc aac ttg tag gagcaagtca ccccacccac         1984
Ala Val Val Thr Thr Ser Ala Asn Leu                                       
        625                 630                                           

ttggggcagc tttggcggtc tgctccctca gtggtcactg ccagacccct gcactctgat     2044

ctgggctggt gagccaggac ttctggtagg ctgttcatgc cctttgtcaa gcgcctcaac     2104

tacgtaagcc tggtgaagcc cagccctgcc ctgggggaca ctggggcagt tagtggtggc     2164

tctcagaagg actggcctgg aaaactggag acagggatgg gaacccaaac atagctgaat     2224

aaaagatggc c                                                          2235


<210>  10
<211>  631
<212>  PRT
<213>  Mus musculus

<400>  10

Met Thr Pro Gly Ile Arg Ala Pro Phe Phe Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ser Leu Lys Gly Phe Leu Ala Leu Pro Ser Glu Glu Asn Ser Val Thr 
            20                  25                  30          


Ser Ser Gln Asp Thr Ser Ser Ser Leu Ala Ser Thr Thr Thr Pro Val 
        35                  40                  45              


His Ser Ser Asn Ser Asp Pro Ala Thr Arg Pro Pro Gly Asp Ser Thr 
    50                  55                  60                  


Ser Ser Pro Val Gln Ser Ser Thr Ser Ser Pro Ala Thr Arg Ala Pro 
65                  70                  75                  80  


Glu Asp Ser Thr Ser Thr Ala Val Leu Ser Gly Thr Ser Ser Pro Ala 
                85                  90                  95      


Thr Thr Ala Pro Val Asn Ser Ala Ser Ser Pro Val Ala His Gly Asp 
            100                 105                 110         


Thr Ser Ser Pro Ala Thr Ser Leu Ser Lys Asp Ser Asn Ser Ser Pro 
        115                 120                 125             


Val Val His Ser Gly Thr Ser Ser Ala Pro Ala Thr Thr Ala Pro Val 
    130                 135                 140                 


Asp Ser Thr Ser Ser Pro Val Val His Gly Gly Thr Ser Ser Pro Ala 
145                 150                 155                 160 


Thr Ser Pro Pro Gly Asp Ser Thr Ser Ser Pro Asp His Ser Ser Thr 
                165                 170                 175     


Ser Ser Pro Ala Thr Arg Ala Pro Glu Asp Ser Thr Ser Thr Ala Val 
            180                 185                 190         


Leu Ser Gly Thr Ser Ser Pro Ala Thr Thr Ala Pro Val Asp Ser Thr 
        195                 200                 205             


Ser Ser Pro Val Ala His Asp Asp Thr Ser Ser Pro Ala Thr Ser Leu 
    210                 215                 220                 


Ser Glu Asp Ser Ala Ser Ser Pro Val Ala His Gly Gly Thr Ser Ser 
225                 230                 235                 240 


Pro Ala Thr Ser Pro Leu Arg Asp Ser Thr Ser Ser Pro Val His Ser 
                245                 250                 255     


Ser Ala Ser Ile Gln Asn Ile Lys Thr Thr Ser Asp Leu Ala Ser Thr 
            260                 265                 270         


Pro Asp His Asn Gly Thr Ser Val Thr Thr Thr Ser Ser Ala Leu Gly 
        275                 280                 285             


Ser Ala Thr Ser Pro Asp His Ser Gly Thr Ser Thr Thr Thr Asn Ser 
    290                 295                 300                 


Ser Glu Ser Val Leu Ala Thr Thr Pro Val Tyr Ser Ser Met Pro Phe 
305                 310                 315                 320 


Ser Thr Thr Lys Val Thr Ser Gly Ser Ala Ile Ile Pro Asp His Asn 
                325                 330                 335     


Gly Ser Ser Val Leu Pro Thr Ser Ser Val Leu Gly Ser Ala Thr Ser 
            340                 345                 350         


Leu Val Tyr Asn Thr Ser Ala Ile Ala Thr Thr Pro Val Ser Asn Gly 
        355                 360                 365             


Thr Gln Pro Ser Val Pro Ser Gln Tyr Pro Val Ser Pro Thr Met Ala 
    370                 375                 380                 


Thr Thr Ser Ser His Ser Thr Ile Ala Ser Ser Ser Tyr Tyr Ser Thr 
385                 390                 395                 400 


Val Pro Phe Ser Thr Phe Ser Ser Asn Ser Ser Pro Gln Leu Ser Val 
                405                 410                 415     


Gly Val Ser Phe Phe Phe Leu Ser Phe Tyr Ile Gln Asn His Pro Phe 
            420                 425                 430         


Asn Ser Ser Leu Glu Asp Pro Ser Ser Asn Tyr Tyr Gln Glu Leu Lys 
        435                 440                 445             


Arg Asn Ile Ser Gly Leu Phe Leu Gln Ile Phe Asn Gly Asp Phe Leu 
    450                 455                 460                 


Gly Ile Ser Ser Ile Lys Phe Arg Ser Gly Ser Val Val Val Glu Ser 
465                 470                 475                 480 


Thr Val Val Phe Arg Glu Gly Thr Phe Ser Ala Ser Asp Val Lys Ser 
                485                 490                 495     


Gln Leu Ile Gln His Lys Lys Glu Ala Asp Asp Tyr Asn Leu Thr Ile 
            500                 505                 510         


Ser Glu Val Lys Val Asn Glu Met Gln Phe Pro Pro Ser Ala Gln Ser 
        515                 520                 525             


Arg Pro Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys 
    530                 535                 540                 


Ile Leu Val Ala Leu Ala Ile Val Tyr Phe Leu Ala Leu Ala Val Cys 
545                 550                 555                 560 


Gln Cys Arg Arg Lys Ser Tyr Gly Gln Leu Asp Ile Phe Pro Thr Gln 
                565                 570                 575     


Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly 
            580                 585                 590         


Arg Tyr Val Pro Pro Gly Ser Thr Lys Arg Ser Pro Tyr Glu Glu Val 
        595                 600                 605             


Ser Ala Gly Asn Gly Ser Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val 
    610                 615                 620                 


Val Thr Thr Ser Ala Asn Leu 
625                 630     


<210>  11
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 
        995                 1000                 1005             


Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 
    1010                 1015                 1020             


Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 
    1025                 1030                 1035             


Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 
    1040                 1045                 1050             


Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 
    1055                 1060                 1065             


Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 
    1085                 1090                 1095             


Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 
    1100                 1105                 1110             


Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 
    1115                 1120                 1125             


Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 
    1130                 1135                 1140             


Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 
    1145                 1150                 1155             


Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 
    1160                 1165                 1170             


Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 
    1175                 1180                 1185             


Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 
    1190                 1195                 1200             


His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 
    1205                 1210                 1215             


Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 
    1220                 1225                 1230             


Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 
    1235                 1240                 1245             


Ala Ala  Thr Ser Ala Asn Leu  
    1250                 1255 


<210>  12
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X= P, A, Q or T

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  X= D or E

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  X= T or S

<400>  12

Pro Ala Pro Gly Ser Thr Ala Pro Xaa Ala His Gly Val Thr Ser Ala 
1               5                   10                  15      


Pro Xaa Xaa Arg 
            20  


<210>  13
<211>  711
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(711)

<400>  13
atg aca ccg ggc acc cag tct cct ttc ttc ctg ctg ctg ctc ctc aca         48
Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr           
1               5                   10                  15                

gtg ctt aca gct acc aca gcc cct aaa ccc gca aca gtt gtt gga tct         96
Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Gly Ser           
            20                  25                  30                    

gtg gtg gta caa ttg act ctg gcc ttc cga gaa ggt acc atc aat gtc        144
Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val           
        35                  40                  45                        

cac gac gtg gag aca cag ttc aat cag tat aaa acg gaa gca gcc tct        192
His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser           
    50                  55                  60                            

cga tat aac ctg acg atc tca gac gtc agc gtg agt gat gtg cca ttt        240
Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe           
65                  70                  75                  80            

cct ttc tct gcc cag tct ggg gct ggg gcc cac ggt gtc acc agc gcc        288
Pro Phe Ser Ala Gln Ser Gly Ala Gly Ala His Gly Val Thr Ser Ala           
                85                  90                  95                

cct gac acc agg ccg gcc ccg ggc tcc acc gcg ccc cca gcc cat ggt        336
Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly           
            100                 105                 110                   

gtc acc tcg gcc ccg gag agc agg ccc gcc cct ggg agc acc gcc ccc        384
Val Thr Ser Ala Pro Glu Ser Arg Pro Ala Pro Gly Ser Thr Ala Pro           
        115                 120                 125                       

cct gca gtg cca ggc tgg ggc atc gcg ctg ctg gtg ctg gtc tgt gtt        432
Pro Ala Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val           
    130                 135                 140                           

ctg gtt gcg ctg gcc att gtc tat ctc att gcc ttg gct gtc tgt cag        480
Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln           
145                 150                 155                 160           

tgc cgc cga aag aac tac ggg cag ctg gac atc ttt cca gcc cgg gat        528
Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp           
                165                 170                 175               

acc tac cat cct atg agc gag tac ccc acc tac cac acc cat ggg cgc        576
Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg           
            180                 185                 190                   

tat gtg ccc cct agc agt acc gat cgt agc ccc tat gag aag gtt tct        624
Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser           
        195                 200                 205                       

gca ggt aat ggt ggc agc agc ctc tct tac aca aac cca gca gtg gca        672
Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala           
    210                 215                 220                           

gcc act tct gcc aac ttg cat cat cac cac cat cac tag                    711
Ala Thr Ser Ala Asn Leu His His His His His His                           
225                 230                 235                               


<210>  14
<211>  236
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  14

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Gly Ser 
            20                  25                  30          


Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val 
        35                  40                  45              


His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser 
    50                  55                  60                  


Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe 
65                  70                  75                  80  


Pro Phe Ser Ala Gln Ser Gly Ala Gly Ala His Gly Val Thr Ser Ala 
                85                  90                  95      


Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
            100                 105                 110         


Val Thr Ser Ala Pro Glu Ser Arg Pro Ala Pro Gly Ser Thr Ala Pro 
        115                 120                 125             


Pro Ala Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 
    130                 135                 140                 


Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 
145                 150                 155                 160 


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                165                 170                 175     


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            180                 185                 190         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        195                 200                 205             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    210                 215                 220                 


Ala Thr Ser Ala Asn Leu His His His His His His 
225                 230                 235     


<210>  15
<211>  200
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  15

Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
1               5                   10                  15      


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
            20                  25                  30          


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
        35                  40                  45              


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Ala His Gly Val Thr 
    50                  55                  60                  


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
65                  70                  75                  80  


His Gly Val Thr Ser Ala Pro Glu Ser Arg Pro Ala Pro Gly Ser Thr 
                85                  90                  95      


Ala Pro Pro Ala Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
            100                 105                 110         


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
        115                 120                 125             


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
    130                 135                 140                 


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
145                 150                 155                 160 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
                165                 170                 175     


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
            180                 185                 190         


Val Ala Ala Thr Ser Ala Asn Leu 
        195                 200 


<210>  16
<211>  687
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(687)

<400>  16
atg gcc gat gaa gct ccg tgt cag tgc cgc cga aag aac tac ggg cag         48
Met Ala Asp Glu Ala Pro Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln           
1               5                   10                  15                

ctg gac atc ttt cca gcc cgg gat acc tac cat cct atg agc gag tac         96
Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr           
            20                  25                  30                    

ccc acc tac cac acc cat ggg cgc tat gtg ccc cct agc agt acc gat        144
Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp           
        35                  40                  45                        

cgt agc ccc tat gag aag gtt tct gca ggt aat ggt ggc agc agc ctc        192
Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu           
    50                  55                  60                            

tct tac aca aac cca gca gtg gca gcc act tct gcc aac ttg tgc caa        240
Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu Cys Gln           
65                  70                  75                  80            

tgc aga aga aaa aat tat ggt caa ctt gac att ttt cct gca aga gat        288
Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp           
                85                  90                  95                

aca tat cat cca atg agt gaa tat cca act tat cac act cat ggc aga        336
Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg           
            100                 105                 110                   

tat gtc cca cca tcg tct aca gat aga tcg cca tac gaa aaa gta tcg        384
Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser           
        115                 120                 125                       

gct gga aat gga ggt agt tca ttg tca tac act aat cct gca gtc gct        432
Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala           
    130                 135                 140                           

gct acg tcc gct aat cta tgt caa tgt cgt agg aaa aac tac ggt caa        480
Ala Thr Ser Ala Asn Leu Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln           
145                 150                 155                 160           

ttg gat ata ttc cca gcc agg gac act tat cat cct atg tcc gaa tac        528
Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr           
                165                 170                 175               

cca acg tac cat aca cat ggc agg tat gtt cct cct tct tca act gat        576
Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp           
            180                 185                 190                   

aga tcc ccg tat gaa aag gta tca gct gga aac ggt gga agt tcc tta        624
Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu           
        195                 200                 205                       

tca tat aca aat ccg gct gtt gcg gcg aca tct gca aat tta cat cat        672
Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu His His           
    210                 215                 220                           

cac cac cat cac tga                                                    687
His His His His                                                           
225                                                                       


<210>  17
<211>  228
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  17

Met Ala Asp Glu Ala Pro Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 
1               5                   10                  15      


Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 
            20                  25                  30          


Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 
        35                  40                  45              


Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 
    50                  55                  60                  


Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu Cys Gln 
65                  70                  75                  80  


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                85                  90                  95      


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            100                 105                 110         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        115                 120                 125             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    130                 135                 140                 


Ala Thr Ser Ala Asn Leu Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 
145                 150                 155                 160 


Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 
                165                 170                 175     


Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 
            180                 185                 190         


Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 
        195                 200                 205             


Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu His His 
    210                 215                 220                 


His His His His 
225             


<210>  18
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  18

Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
1               5                   10                  15      


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
            20                  25                  30          


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
        35                  40                  45              


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
    50                  55                  60                  


Val Ala Ala Thr Ser Ala Asn Leu Cys Gln Cys Arg Arg Lys Asn Tyr 
65                  70                  75                  80  


Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser 
                85                  90                  95      


Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser 
            100                 105                 110         


Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser 
        115                 120                 125             


Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
    130                 135                 140                 


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
145                 150                 155                 160 


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
                165                 170                 175     


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
            180                 185                 190         


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
        195                 200                 205             


Val Ala Ala Thr Ser Ala Asn Leu 
    210                 215     


<210>  19
<211>  89
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Ser Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Leu Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Asp Lys Arg Glu Ala Glu Ala 
                85                  


<210>  20
<211>  89
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  20

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Leu Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Asp Lys Arg Glu Ala Glu Ala 
                85                  


<210>  21
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  21

Met Ala Asp Glu Ala Pro 
1               5       


<210>  22
<211>  779
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (13)..(771)

<400>  22
gaattcgcca cc atg aca cca ggg aca caa agc cca ttt ttc cta ttg cta       51
              Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu         
              1               5                   10                      

ctc ttg act gtc tta acc gca acc act gct cca aaa cca gca act gtg         99
Leu Leu Thr Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val           
    15                  20                  25                            

gtc ggt tca gtt gtg gtt cag tta aca ctt gct ttt aga gaa gga aca        147
Val Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr           
30                  35                  40                  45            

att aac gta cac gat gta gaa act caa ttc aat caa tac aag aca gaa        195
Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu           
                50                  55                  60                

gcg gcc agt aga tac aat ttg aca att tct gac gtt tct gtg tct gac        243
Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp           
            65                  70                  75                    

gtg cca ttt cca ttc tcc gct caa tca ggt gcc ggt gca cat ggc gta        291
Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Ala His Gly Val           
        80                  85                  90                        

acg tcc tac ctg gat aca aga cct gca cca gta tac ctc gca cct cct        339
Thr Ser Tyr Leu Asp Thr Arg Pro Ala Pro Val Tyr Leu Ala Pro Pro           
    95                  100                 105                           

gct cat gga gtt aca tct gcc cct gag tcc agg cca gct cct ggt tct        387
Ala His Gly Val Thr Ser Ala Pro Glu Ser Arg Pro Ala Pro Gly Ser           
110                 115                 120                 125           

acc gca cca cct gct gtt cca ggt tgg ggc atc gcc ttg ctg gtc tta        435
Thr Ala Pro Pro Ala Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu           
                130                 135                 140               

gtt tgt gtc ctg gtg tac ttg gct ata gtc tac tta atc gca cta gct        483
Val Cys Val Leu Val Tyr Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala           
            145                 150                 155                   

gta tgc cag gtt aga aga aag aac tac ggc caa ttg gat atc ttt cca        531
Val Cys Gln Val Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro           
        160                 165                 170                       

gcg aga gat act tat cat cca atg tca gag tat cca act tat cat aca        579
Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr           
    175                 180                 185                           

cat gga cgt tat gtt cca cct tcc tct ctt ttt aga agt cct tac gaa        627
His Gly Arg Tyr Val Pro Pro Ser Ser Leu Phe Arg Ser Pro Tyr Glu           
190                 195                 200                 205           

aaa gtt tca gca ggt aat gga ggc tca tac ctt tca tac act aat cca        675
Lys Val Ser Ala Gly Asn Gly Gly Ser Tyr Leu Ser Tyr Thr Asn Pro           
                210                 215                 220               

gcc gtt gct gcg act tct gca aac ttg gaa cct gcc agt ggg agc gct        723
Ala Val Ala Ala Thr Ser Ala Asn Leu Glu Pro Ala Ser Gly Ser Ala           
            225                 230                 235                   

gct tta tgg ggt caa gat gta acc tct cat cac cat cac cac cat tag        771
Ala Leu Trp Gly Gln Asp Val Thr Ser His His His His His His               
        240                 245                 250                       

gcggccgc                                                               779


<210>  23
<211>  252
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  23

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Gly Ser 
            20                  25                  30          


Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val 
        35                  40                  45              


His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser 
    50                  55                  60                  


Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe 
65                  70                  75                  80  


Pro Phe Ser Ala Gln Ser Gly Ala Gly Ala His Gly Val Thr Ser Tyr 
                85                  90                  95      


Leu Asp Thr Arg Pro Ala Pro Val Tyr Leu Ala Pro Pro Ala His Gly 
            100                 105                 110         


Val Thr Ser Ala Pro Glu Ser Arg Pro Ala Pro Gly Ser Thr Ala Pro 
        115                 120                 125             


Pro Ala Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 
    130                 135                 140                 


Leu Val Tyr Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 
145                 150                 155                 160 


Val Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                165                 170                 175     


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            180                 185                 190         


Tyr Val Pro Pro Ser Ser Leu Phe Arg Ser Pro Tyr Glu Lys Val Ser 
        195                 200                 205             


Ala Gly Asn Gly Gly Ser Tyr Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    210                 215                 220                 


Ala Thr Ser Ala Asn Leu Glu Pro Ala Ser Gly Ser Ala Ala Leu Trp 
225                 230                 235                 240 


Gly Gln Asp Val Thr Ser His His His His His His 
                245                 250         


<210>  24
<211>  1727
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(1719)

<400>  24
atg aga ttt cct tca att ttt act gca gtt tta ttc gca gca tcc tcc         48
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser           
1               5                   10                  15                

gca tca gct gct cca gtc aac act aca aca gaa gat gaa acg gca caa         96
Ala Ser Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln           
            20                  25                  30                    

att ccg gct gaa gct gtc atc ggt tac tta gat tta gaa ggg gat ttc        144
Ile Pro Ala Glu Ala Val Ile Gly Tyr Leu Asp Leu Glu Gly Asp Phe           
        35                  40                  45                        

gat gtt gct gtt ttg cca ttt tcc aac agc aca aat aac ggg tta ttg        192
Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu           
    50                  55                  60                            

ttt ata aat act act att gcc agc att gct gct aaa gaa gaa ggg gta        240
Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val           
65                  70                  75                  80            

tct cta gat aaa aga gag gct gaa gct act agt atg act cca ggt aca        288
Ser Leu Asp Lys Arg Glu Ala Glu Ala Thr Ser Met Thr Pro Gly Thr           
                85                  90                  95                

caa tca cca ttc ttt ttg ttg cta ttg tta acc gtt ctg acc gtc gtt        336
Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val           
            100                 105                 110                   

act gga tca ggt cac gcc tct agt acg cca gga ggt gaa aaa gag act        384
Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr           
        115                 120                 125                       

tct gcc aca caa aga tcc tct gtc cca tca tct act gag aaa aat gca        432
Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala           
    130                 135                 140                           

gtt tct atg aca tcc tca gta ttg tcc tca cat tcc cct ggt tct ggt        480
Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly           
145                 150                 155                 160           

tcc tct aca act cag gga caa gat gtg acg ttg gct cct gca acc gaa        528
Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu           
                165                 170                 175               

cca gcc tcc ggg agt gcg gct cta tgg ggg caa gat gtc aca tca gtc        576
Pro Ala Ser Gly Ser Ala Ala Leu Trp Gly Gln Asp Val Thr Ser Val           
            180                 185                 190                   

cca gta aca aga cct gca tta gga tca aca act cca cct gct cac gat        624
Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp           
        195                 200                 205                       

gta aca agc gca cca gat aac aag cct gca cct ggc tct acc gct cca        672
Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro           
    210                 215                 220                           

cct gcc cac ggc gta aca agt tat ttg gat aca aga cca gca cct gtt        720
Pro Ala His Gly Val Thr Ser Tyr Leu Asp Thr Arg Pro Ala Pro Val           
225                 230                 235                 240           

tac ttg gca cct cct gct cac ggt gtt aca tct gct cct gac aat aga        768
Tyr Leu Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg           
                245                 250                 255               

cca gct tta gga tct act gct cct cca gtg cat aac gta act tca gcc        816
Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala           
            260                 265                 270                   

tca ggc tcc gca tcc ggt tct gct tca aca ctt gtc cac aat gga act        864
Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr           
        275                 280                 285                       

tct gct aga gca aca aca aca cca gcc tct aaa agt act cct ttc tct        912
Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser           
    290                 295                 300                           

atc cca tct cat cat tct gat act cct aca act tta gct tca cac tca        960
Ile Pro Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser           
305                 310                 315                 320           

act aaa aca gat gcc agt agt act cat cat tcc tct gta cca cct ctt       1008
Thr Lys Thr Asp Ala Ser Ser Thr His His Ser Ser Val Pro Pro Leu           
                325                 330                 335               

aca tct tct aat cat tca aca tca cca caa ctc tcc act ggt gtg agc       1056
Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser           
            340                 345                 350                   

ttc ttc ttc ctc tct ttt cac att tca aac ctg caa ttc aac tct tcc       1104
Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser           
        355                 360                 365                       

cta gag gac cca tct acg gac tat tat caa gag ttg caa aga gat atc       1152
Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile           
    370                 375                 380                           

agc gaa atg ttt cta cag atc tac aag caa ggt gga ttt ttg gga cta       1200
Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu           
385                 390                 395                 400           

tca aac ata aag ttt aga cca ggc agc gtt gtc gtc caa ctt acc tta       1248
Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu           
                405                 410                 415               

gct ttt aga gaa ggg act att aat gtt cat gat gtg gaa acc cag ttt       1296
Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe           
            420                 425                 430                   

aat caa tac aag aca gaa gca gct tca cga tac aat ttg aca att tcc       1344
Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser           
        435                 440                 445                       

gat gtt tct gtt tcc gac gta cct ttt cca ttc tct gcc caa agt ggt       1392
Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly           
    450                 455                 460                           

gcg ggt gtt cca ggt tgg ggg att gct ctg tta gtg tta gtc tgt gtt       1440
Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val           
465                 470                 475                 480           

ctc gtt tac tta gct atc gta tac tta ata gcc cta gca gtt tgc cag       1488
Leu Val Tyr Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln           
                485                 490                 495               

gtg aga agg aaa aac tat ggc caa ttg gat atc ttt cct gct aga gac       1536
Val Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp           
            500                 505                 510                   

act tac cat cca atg tct gaa tat cca acc tac cat aca cat ggt agg       1584
Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg           
        515                 520                 525                       

tac gtg cca cca tca agt ctt ttt cgt tca cca tac gaa aaa gtt agc       1632
Tyr Val Pro Pro Ser Ser Leu Phe Arg Ser Pro Tyr Glu Lys Val Ser           
    530                 535                 540                           

gca ggt aat ggc ggc agt tac ctg tca tac act aac cca gcg gtt gct       1680
Ala Gly Asn Gly Gly Ser Tyr Leu Ser Tyr Thr Asn Pro Ala Val Ala           
545                 550                 555                 560           

gcg gct agt gcc aat ctt cat cac cat cat cac cat taa gcggccgc          1727
Ala Ala Ser Ala Asn Leu His His His His His His                           
                565                 570                                   


<210>  25
<211>  572
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  25

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Ser Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Leu Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Asp Lys Arg Glu Ala Glu Ala Thr Ser Met Thr Pro Gly Thr 
                85                  90                  95      


Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
            100                 105                 110         


Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr 
        115                 120                 125             


Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala 
    130                 135                 140                 


Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly 
145                 150                 155                 160 


Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu 
                165                 170                 175     


Pro Ala Ser Gly Ser Ala Ala Leu Trp Gly Gln Asp Val Thr Ser Val 
            180                 185                 190         


Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp 
        195                 200                 205             


Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro 
    210                 215                 220                 


Pro Ala His Gly Val Thr Ser Tyr Leu Asp Thr Arg Pro Ala Pro Val 
225                 230                 235                 240 


Tyr Leu Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg 
                245                 250                 255     


Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala 
            260                 265                 270         


Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr 
        275                 280                 285             


Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser 
    290                 295                 300                 


Ile Pro Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser 
305                 310                 315                 320 


Thr Lys Thr Asp Ala Ser Ser Thr His His Ser Ser Val Pro Pro Leu 
                325                 330                 335     


Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser 
            340                 345                 350         


Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser 
        355                 360                 365             


Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile 
    370                 375                 380                 


Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu 
385                 390                 395                 400 


Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
                405                 410                 415     


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
            420                 425                 430         


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser 
        435                 440                 445             


Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly 
    450                 455                 460                 


Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 
465                 470                 475                 480 


Leu Val Tyr Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 
                485                 490                 495     


Val Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
            500                 505                 510         


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
        515                 520                 525             


Tyr Val Pro Pro Ser Ser Leu Phe Arg Ser Pro Tyr Glu Lys Val Ser 
    530                 535                 540                 


Ala Gly Asn Gly Gly Ser Tyr Leu Ser Tyr Thr Asn Pro Ala Val Ala 
545                 550                 555                 560 


Ala Ala Ser Ala Asn Leu His His His His His His 
                565                 570         


