                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate 
       Dinarello, Charles
       Lewis, Eli
 
<120>  COMPOSITIONS, METHODS AND USES OF ALPHA 1-ANTITRYPSIN FOR EARLY 
       INTERVENTION IN BONE MARROW TRANSPLANTATION AND TREATMENT OF 
       GRAFT VERSUS HOST DISEASE

<130>  479487.5

<150>  13/209,349
<151>  2011-08-12

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  1

Phe Val Phe Leu Met 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  2

Phe Val Phe Ala Met 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  3

Phe Val Ala Leu Met 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  4

Phe Val Phe Leu Ala 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  5

Phe Leu Val Phe Ile 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  6

Phe Leu Met Ile Ile 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  7

Phe Leu Phe Val Leu 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  8

Phe Leu Phe Val Val 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  9

Phe Leu Phe Leu Ile 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  10

Phe Leu Phe Phe Ile 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  11

Phe Leu Met Phe Ile 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  12

Phe Met Leu Leu Ile 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  13

Phe Ile Ile Met Ile 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  14

Phe Leu Phe Cys Ile 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  15

Phe Leu Phe Ala Val 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  16

Phe Val Tyr Leu Ile 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  17

Phe Ala Phe Leu Met 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  18

Ala Val Phe Leu Met 
1               5   


<210>  19
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Pro Ser Ser Val Ser Trp Gly Ile Leu 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  20

Leu Ala Gly Leu Cys Cys Leu Val Pro Val 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Gln Lys Thr Asp Thr Ser His His Asp 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Asp His Pro Thr Phe Asn Lys Ile Thr 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  25

Tyr Arg Gln Leu Ala His Gln Ser Asn Ser 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Thr Asn Ile Phe Phe Ser Pro Val Ser Ile 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Thr Ala Phe Ala Met Leu Ser Leu Gly 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  28

Thr Lys Ala Asp Thr His Asp Glu Ile Leu 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Pro Glu Ala Gln Ile His Glu Gly Phe Gln 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Leu Phe Leu Ser Glu Gly Leu Lys Leu Val 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Lys Phe Leu Glu Asp Val Lys Lys Leu 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  35

Tyr His Ser Glu Ala Phe Thr Val Asn Phe 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Asp His Glu Glu Ala Lys Lys Gln Ile 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  37

Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  38

Lys Ile Val Asp Leu Val Lys Glu Leu Asp 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  39

Arg Asp Thr Val Phe Ala Leu Val Asn Tyr 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  40

Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  41

Phe Glu Val Lys Asp Thr Glu Asp Glu Asp 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  42

Phe His Val Asp Gln Val Thr Thr Val Lys 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  43

Val Pro Met Met Lys Arg Leu Gly Met Phe 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  44

Asn Ile Gln His Cys Lys Lys Leu Ser Ser 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  45

Trp Val Leu Leu Met Lys Tyr Leu Gly Asn 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala Thr Ala Ile Phe Phe Leu Pro Asp Glu 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Lys Leu Gln His Leu Glu Asn Glu Leu 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  48

Thr His Asp Ile Ile Thr Lys Phe Leu Glu 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  49

Asn Glu Asp Arg Arg Ser Ala Ser Leu His 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  50

Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Leu Lys Ser Val Leu Gly Gln Leu Gly 
1               5                   10  


<210>  52
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  52

Ile Thr Lys Val Phe Ser Asn Gly Ala Asp 
1               5                   10  


<210>  53
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  53

Leu Ser Gly Val Thr Glu Glu Ala Pro Leu 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  54

Lys Leu Ser Lys Ala Val His Lys Ala Val 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  55

Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Gly Ala Met Phe Leu Glu Ala Ile Pro 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ser Ile Pro Pro Glu Val Lys Phe Asn 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  58

Lys Pro Phe Val Phe Leu Met Ile Glu Gln 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  59

Asn Thr Lys Ser Pro Leu Phe Met Gly Lys 
1               5                   10  


<210>  60
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  60

Val Val Asn Pro Thr Gln Lys 
1               5           


<210>  61
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Ala Gly Leu Cys Cys 
1               5                   10                  15      


Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala Gln 
            20                  25                  30          


Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn Lys 
        35                  40                  45              


Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln Leu 
    50                  55                  60                  


Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser Ile 
65                  70                  75                  80  


Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr His 
                85                  90                  95      


Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro Glu 
            100                 105                 110         


Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn Gln 
        115                 120                 125             


Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu Ser 
    130                 135                 140                 


Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys Leu 
145                 150                 155                 160 


Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp His Glu Glu Ala 
                165                 170                 175     


Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys Ile 
            180                 185                 190         


Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu Val 
        195                 200                 205             


Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val Lys 
    210                 215                 220                 


Asp Thr Glu Asp Glu Asp Phe His Val Asp Gln Val Thr Thr Val Lys 
225                 230                 235                 240 


Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys Lys 
                245                 250                 255     


Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala Thr 
            260                 265                 270         


Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu Asn 
        275                 280                 285             


Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp Arg 
    290                 295                 300                 


Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr Tyr 
305                 310                 315                 320 


Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe Ser 
                325                 330                 335     


Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys Leu 
            340                 345                 350         


Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr 
        355                 360                 365             


Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro 
    370                 375                 380                 


Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln 
385                 390                 395                 400 


Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln 
                405                 410                 415     


Lys 
    


<210>  62
<211>  394
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (355)..(358)
<223>  novel sequence

<220>
<221>  MISC_FEATURE
<222>  (356)..(357)
<223>  Xaa=any amino acid

<400>  62

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp His Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Asp Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Arg Xaa Xaa Arg Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


<210>  63
<211>  394
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (355)..(358)
<223>  native sequence

<400>  63

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


