                         SEQUENCE LISTING

<110>  EMORY UNIVERSITY
       Parkos, Charles
       Weber, Dominique
 
<120>  JAML SPECIFIC BINDING AGENTS, ANTIBODIES, AND USES RELATED 
       THERETO

<130>  11181-PCT

<150>  US 61/523,886
<151>  2011-08-16

<150>  61/563,064
<151>  2011-11-23

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Tyr Glu Met His 
1               5   


<210>  2
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  2

Trp Ile Gly Ile Ile His Pro Gly Ser Gly Gly Thr Val Tyr Asn His 
1               5                   10                  15      


Lys Phe Lys Gly Lys Ala 
            20          


<210>  3
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Arg Arg Arg Tyr Tyr Gly Ser Ser Tyr Asn Trp Tyr Phe Asp Val 
1               5                   10                  15      


<210>  4
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Tyr Gly Met Ala 
1               5   


<210>  5
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Ile Ser Asn Leu Ala Tyr Ser Ile Tyr Tyr Ser Asp Thr Val Thr 
1               5                   10                  15      


<210>  6
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Arg Gly Asp Tyr Ser Gly Gly Met Met Asp Tyr 
1               5                   10          


<210>  7
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Tyr Ala Trp Asn 
1               5   


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Ser Ser Gly Asn Ser Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Gly Ala Thr Gly Tyr Ser Met Asp Tyr 
1               5                   10  


<210>  10
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser Leu Ala Trp 
1               5                   10              


<210>  11
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  11

Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg 
1               5                   10          


<210>  12
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  12

Tyr Phe Cys Glu Gln Thr Tyr Asp Val Pro Leu Thr Phe Gly Ala Gly 
1               5                   10                  15      


Thr 
    


<210>  13
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
1               5                   10                  


<210>  14
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe 
1               5                   10              


<210>  15
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln His Ile Arg Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser 
1               5                   10                  


<210>  16
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu 
1               5                   10      


<210>  17
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
1               5                   10              


<210>  18
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  18

His Gln Tyr His Arg Ser Pro Phe Thr Phe Gly Ser 
1               5                   10          


<210>  19
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Leu Ala Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile His Pro Gly Ser Gly Gly Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Thr Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Arg Tyr Tyr Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Asn 
        115     


<210>  20
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp 
            20                  25                  30          


Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp 
        35                  40                  45              


Val Ala Phe Ile Ser Asn Leu Ala Tyr Ser Ile Tyr Tyr Ser Asp Thr 
    50                  55                  60                  


Val Thr Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asp Tyr Ser Gly Gly Met Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr 
        


<210>  21
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Ser Ser Gly Asn Ser Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ala Thr Gly Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Lys 
        115     


<210>  22
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  22

Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly Glu Thr 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile Tyr Asn 
        35                  40                  45              


Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Met Gln Pro Glu Asp 
65                  70                  75                  80  


Thr Ala Thr Tyr Phe Cys Glu Gln Thr Tyr Asp Val Pro Leu Thr Phe 
                85                  90                  95      


Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 


<210>  23
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  23

Val Leu Thr Ser Gln Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
1               5                   10                  15      


Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr 
            20                  25                  30          


Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val 
65                  70                  75                  80  


Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg Glu Leu 
                85                  90                  95      


Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys 
            100                 105     


<210>  24
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  24

Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu Arg 
1               5                   10                  15      


Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  25
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  25

His Pro Gly Ser Gly Gly Thr Val Tyr Asn 
1               5                   10  


<210>  26
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  26

Tyr Tyr Gly Ser Ser Tyr Asn 
1               5           


<210>  27

<400>  27
000

<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  28

His Pro Gly Ser Gly Gly Thr Val Tyr Asn 
1               5                   10  


<210>  29

<400>  29
000

<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Ile His Pro Gly Ser Gly Gly Thr Val Tyr 
1               5                   10  


<210>  31
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  31

Tyr Gly Ser Ser Tyr Asn 
1               5       


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

His Pro Gly Ser Gly Gly Thr Val Tyr 
1               5                   


<210>  33
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  33

Tyr Gly Ser Ser Tyr 
1               5   


<210>  34
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  34

His Pro Gly Ser Gly Gly Thr Val 
1               5               


<210>  35
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Ser Ser Tyr Asn 
1               5   


<210>  36
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  36

His Pro Gly Ser Gly Gly Thr 
1               5           


<210>  37
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  37

Pro Gly Ser Gly Gly Thr 
1               5       


<210>  38
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Ala Ser Glu Asn Ile Tyr Tyr Ser Leu Ala 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  39

Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser 
1               5                   10      


<210>  40
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Ser Glu Asn Ile Tyr Tyr Ser Leu Ala 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Asn Ser Leu Glu Asp Gly Val Pro Ser 
1               5                   10  


<210>  42
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Ser Glu Asn Ile Tyr Tyr Ser Leu 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Asn Ser Leu Glu Asp Gly Val Pro 
1               5                   


<210>  44
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser Glu Asn Ile Tyr Tyr Ser Leu 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  45

Asn Ser Leu Glu Asp Gly Val Pro 
1               5               


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  46

Ser Glu Asn Ile Tyr Tyr Ser 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  47

Asn Ser Leu Glu Asp Gly Val 
1               5           


<210>  48
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  48

Glu Asn Ile Tyr Tyr Ser 
1               5       


<210>  49
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  49

Ser Leu Glu Asp Gly Val 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Ile Ile His Pro Gly 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  51

Ile Gly Ile Ile His Pro 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  52

Gly Ile Ile His Pro Gly 
1               5       


<210>  53
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Ile Ile His Pro 
1               5   


<210>  54
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  54

Pro Gly Ser Gly Gly Thr Val Tyr Asn His 
1               5                   10  


<210>  55
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly Ser Gly Gly Thr Val Tyr Asn His 
1               5                   


<210>  56
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  56

Ser Gly Gly Thr Val Tyr Asn His 
1               5               


<210>  57
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Gly Thr Val Tyr Asn His 
1               5           


<210>  58
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  58

Arg Ala Ser Glu Asn Ile Tyr Tyr 
1               5               


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  59

Asn Ala Asn Ser Leu Glu Asp Gly Val Pro 
1               5                   10  


<210>  60
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  60

Arg Ala Ser Glu Asn Ile Tyr 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  61

Arg Ala Ser Glu Asn Ile Tyr 
1               5           


<210>  62
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  62

Arg Ala Ser Glu Asn Ile 
1               5       


<210>  63
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  63

Arg Ala Ser Glu Asn 
1               5   


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

Ala Asn Ser Leu Glu Asp Gly Val Pro 
1               5                   


<210>  65
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  65

Asn Ser Leu Glu Asp Gly Val Pro 
1               5               


<210>  66
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Phe Cys Pro Leu Lys Leu Ile Leu Leu Pro Val Leu Leu Asp Tyr 
1               5                   10                  15      


Ser Leu Gly Leu Asn Asp Leu Asn Val Ser Pro Pro Glu Leu Thr Val 
            20                  25                  30          


His Val Gly Asp Ser Ala Leu Met Gly Cys Val Phe Gln Ser Thr Glu 
        35                  40                  45              


Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr Leu Ser Pro Gly Glu His 
    50                  55                  60                  


Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr Ser Asn Leu Ser Val Pro 
65                  70                  75                  80  


Ile Gly Arg Phe Gln Asn Arg Val His Leu Met Gly Asp Ile Leu Cys 
                85                  90                  95      


Asn Asp Gly Ser Leu Leu Leu Gln Asp Val Gln Glu Ala Asp Gln Gly 
            100                 105                 110         


Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly Glu Ser Gln Val Phe Lys 
        115                 120                 125             


Lys Ala Val Val Leu His Val Leu Pro Glu Glu Pro Lys Glu Leu Met 
    130                 135                 140                 


Val His Val Gly Gly Leu Ile Gln Met Gly Cys Val Phe Gln Ser Thr 
145                 150                 155                 160 


Glu Val Lys His Val Thr Lys Val Glu Trp Ile Phe Ser Gly Arg Arg 
                165                 170                 175     


Ala Lys Glu Glu Ile Val Phe Arg Tyr Tyr His Lys Leu Arg Met Ser 
            180                 185                 190         


Val Glu Tyr Ser Gln Ser Trp Gly His Phe Gln Asn Arg Val Asn Leu 
        195                 200                 205             


Val Gly Asp Ile Phe Arg Asn Asp Gly Ser Ile Met Leu Gln Gly Val 
    210                 215                 220                 


Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys Ser Ile His Leu Gly Asn 
225                 230                 235                 240 


Leu Val Phe Lys Lys Thr Ile Val Leu His Val Ser Pro Glu Glu Pro 
                245                 250                 255     


Arg Thr Leu Val Thr Pro Ala Ala Leu Arg Pro Leu Val Leu Gly Gly 
            260                 265                 270         


Asn Gln Leu Val Ile Ile Val Gly Ile Val Cys Ala Thr Ile Leu Leu 
        275                 280                 285             


Leu Pro Val Leu Ile Leu Ile Val Lys Lys Thr Cys Gly Asn Lys Ser 
    290                 295                 300                 


Ser Val Asn Ser Thr Val Leu Val Lys Asn Thr Lys Lys Thr Asn Pro 
305                 310                 315                 320 


Glu Ile Lys Glu Lys Pro Cys His Phe Glu Arg Cys Glu Gly Glu Lys 
                325                 330                 335     


His Ile Tyr Ser Pro Ile Ile Val Arg Glu Val Ile Glu Glu Glu Glu 
            340                 345                 350         


Pro Ser Glu Lys Ser Glu Ala Thr Tyr Met Thr Met His Pro Val Trp 
        355                 360                 365             


Pro Ser Leu Arg Ser Asp Arg Asn Asn Ser Leu Glu Lys Lys Ser Gly 
    370                 375                 380                 


Gly Gly Met Pro Lys Thr Gln Gln Ala Phe 
385                 390                 


<210>  67
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  67
gctagcacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaatg a                                                981


<210>  68
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  69
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  69
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  70
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  70

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  71
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  71
ggccaaccga aagcggcgcc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttcata g                                                321


<210>  72
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  72

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  73
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  73

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  74
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  74

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Leu 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  75
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  76
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  76

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  77
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser 
225                 230                 235                 240 


Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr 
                245                 250                 255     


Tyr Ser Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu 
            260                 265                 270         


Leu Ile Tyr Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe 
        275                 280                 285             


Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Met 
    290                 295                 300                 


Gln Pro Glu Asp Thr Ala Thr Tyr Phe Cys Glu Gln Thr Tyr Asp Val 
305                 310                 315                 320 


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
                325                 330         


<210>  78
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly Glu 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile Tyr 
        35                  40                  45              


Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Met Gln Pro Glu 
65                  70                  75                  80  


Asp Thr Ala Thr Tyr Phe Cys Glu Gln Thr Tyr Asp Val Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Asp Lys Thr His Thr Cys Pro 
            100                 105                 110         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        115                 120                 125             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    130                 135                 140                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
145                 150                 155                 160 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                165                 170                 175     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            180                 185                 190         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        195                 200                 205             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    210                 215                 220                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
225                 230                 235                 240 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                245                 250                 255     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            260                 265                 270         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        275                 280                 285             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    290                 295                 300                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
305                 310                 315                 320 


Tyr Thr Gln Lys Ser Leu Ser 
                325         


<210>  79
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys Asp Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val 
225                 230                 235                 240 


Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Leu Ala Tyr Thr 
                245                 250                 255     


Phe Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly 
            260                 265                 270         


Leu Glu Trp Ile Gly Ile Ile His Pro Gly Ser Gly Gly Thr Val Tyr 
        275                 280                 285             


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    290                 295                 300                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Thr 
305                 310                 315                 320 


Val Tyr Tyr Cys Thr Arg Arg Arg Tyr Tyr Gly Ser Ser Tyr Trp Tyr 
                325                 330                 335     


Phe Asp Val Trp Gly Ala Gly Asn 
            340                 


<210>  80
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Asp Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Leu Ala Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ile Ile His Pro Gly Ser Gly Gly Thr Val Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Thr Val Tyr Tyr 
                85                  90                  95      


Cys Thr Arg Arg Arg Tyr Tyr Gly Ser Ser Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        115                 120                 125             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    130                 135                 140                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
145                 150                 155                 160 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                165                 170                 175     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            180                 185                 190         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        195                 200                 205             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    210                 215                 220                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
225                 230                 235                 240 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                245                 250                 255     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            260                 265                 270         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        275                 280                 285             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    290                 295                 300                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
305                 310                 315                 320 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                325                 330                 335     


Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 


<210>  81
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  81

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  82
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  82

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210>  83
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly Glu 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile Tyr 
        35                  40                  45              


Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Met Gln Pro Glu 
65                  70                  75                  80  


Asp Thr Ala Thr Tyr Phe Cys Glu Gln Thr Tyr Asp Val Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Ala Asp Ala Ala Pro Thr 
            100                 105                 110         


Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala 
        115                 120                 125             


Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Arg Asp Ile Asn Val 
    130                 135                 140                 


Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser 
145                 150                 155                 160 


Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys 
            180                 185                 190         


Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn 
        195                 200                 205             


Arg Asn Glu Cys 
    210         


