
                                SEQUENCE LISTING

<110> Cummings, W., Jason
      Yabuki, Munehisa  
      Leppard, John, Benjamin
      Wood, Christi, L.
      Maizels, Nancy
      Allison, Daniel, S.
      Tjoelker, Larry, W.

<110> OMEROS CORPORATION     

<120> ANTI-FZD10 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE

<130> 980087.404PC

<140> PCT                  
<141> 2012-08-09

<150> US 61/523,102
<151> 2011-08-12

<150> US 61/548,110
<151> 2011-10-17

<160> 40

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 126
<212> PRT
<213> Gallus gallus

<400> 1
Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly
 1               5                  10                  15      
Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Asn Met Phe Trp Val Arg Gln Glu Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Tyr Pro Asn Tyr Gly Ser Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg
65                  70                  75                  80  
Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Phe Cys
                85                  90                  95      
Ala Lys Ser Gly Tyr Gly Gly Ser Trp Gly Gly Tyr Ile Ala Asp Asp
            100                 105                 110         
Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 125     


<210> 2
<211> 107
<212> PRT
<213> Gallus gallus

<400> 2
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr
            20                  25                  30          
Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile
        35                  40                  45              
Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala
65                  70                  75                  80  
Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala
                85                  90                  95      
Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105         


<210> 3
<211> 107
<212> PRT
<213> Gallus gallus

<400> 3
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Asp Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr
            20                  25                  30          
Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile
        35                  40                  45              
Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala
65                  70                  75                  80  
Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala
                85                  90                  95      
Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105         


<210> 4
<211> 108
<212> PRT
<213> Gallus gallus

<400> 4
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Ser Asp Ser Ser Tyr Ala Gly Ser Tyr Tyr
            20                  25                  30          
Tyr Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu
        35                  40                  45              
Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg
65                  70                  75                  80  
Ala Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly
                85                  90                  95      
Ala Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105             


<210> 5
<211> 5
<212> PRT
<213> Gallus gallus

<400> 5
Ser Phe Asn Met Phe
 1               5  


<210> 6
<211> 17
<212> PRT
<213> Gallus gallus

<400> 6
Gly Ile Asp Asp Asp Gly Ser Tyr Pro Asn Tyr Gly Ser Ala Val Lys
 1               5                  10                  15      
Gly
    


<210> 7
<211> 17
<212> PRT
<213> Gallus gallus

<400> 7
Ser Gly Tyr Gly Gly Ser Trp Gly Gly Tyr Ile Ala Asp Asp Ile Asp
 1               5                  10                  15      
Ala
    


<210> 8
<211> 13
<212> PRT
<213> Gallus gallus

<400> 8
Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr Gly
 1               5                  10              


<210> 9
<211> 13
<212> PRT
<213> Gallus gallus

<400> 9
Ser Gly Asp Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr Gly
 1               5                  10              


<210> 10
<211> 14
<212> PRT
<213> Gallus gallus

<400> 10
Ser Gly Ser Asp Ser Ser Tyr Ala Gly Ser Tyr Tyr Tyr Gly
 1               5                  10                  


<210> 11
<211> 7
<212> PRT
<213> Gallus gallus

<400> 11
Tyr Asn Asn Lys Arg Pro Ser
 1               5          


<210> 12
<211> 9
<212> PRT
<213> Gallus gallus

<400> 12
Gly Ser Ala Asp Asn Ser Gly Ala Ala
 1               5                  


<210> 13
<211> 125
<212> PRT
<213> Gallus gallus

<400> 13
Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly
 1               5                  10                  15      
Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Asn
            20                  25                  30          
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Gly Thr Arg Tyr Ala Pro Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg
65                  70                  75                  80  
Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys
                85                  90                  95      
Thr Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile
            100                 105                 110         
Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser
        115                 120                 125 


<210> 14
<211> 5
<212> PRT
<213> Gallus gallus

<400> 14
Ser Asn Ala Met Gly
 1               5      


<210> 15
<211> 17
<212> PRT
<213> Gallus gallus

<400> 15
Gly Ile Asp Asp Asp Gly Ser Gly Thr Arg Tyr Ala Pro Ala Val Lys 
 1               5                  10                  15
Gly      


<210> 16
<211> 16
<212> PRT
<213> Gallus gallus

<400> 16
Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile Asp Ala
 1               5                  10                  15  


<210> 17
<211> 107
<212> PRT
<213> Gallus gallus

<400> 17
Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Leu Gly Gly Thr Val
 1               5                  10                  15      
Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr
            20                  25                  30          
Gly Trp Tyr Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile
        35                  40                  45              
Tyr Asp Asn Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala
65                  70                  75                  80  
Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala
                85                  90                  95      
Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu
            100                 105         


<210> 18
<211> 7
<212> PRT
<213> Gallus gallus

<400> 18
Asp Asn Asp Lys Arg Pro Ser
 1               5          


<210> 19
<211> 378
<212> DNA
<213> Gallus gallus

<400> 19
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccggaggagc gctcagcctc 60
gtctgcaagg cctccgggtt caccttcagc agcttcaaca tgttctgggt gcgacaggag 120
cccggcaaag ggctggagtg ggtcgctggt attgatgatg atggtagtta cccaaactac 180
gggtcggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgagg 240
ctgcagctga acaacctcag ggctgaggac accggcacct acttctgcgc caaaagtggt 300
tatggtggta gttggggtgg ttatattgct gatgatatcg acgcatgggg ccacgggacc 360
gaagtcatcg tctcctcc                                               378

<210> 20
<211> 322
<212> DNA
<213> Gallus gallus

<400> 20
gcgctgactc agcctgcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc 60
tccgggggtg gcagctatgc tggaagttac tattatggct ggtaccagca gaaggcacct 120
ggcagtgccc ctgtcactct gatctattac aacaacaaga gaccctcgga catcccttca 180
cgattctccg gttccctatc cggctccaca aacacattaa ccatcactgg ggtccgagcc 240
gatgacgagg ctgtctattt ctgtgggagt gcagacaaca gtggtgctgc atttggggcc 300
gggacaaccc tgacagtact tg                                          322

<210> 21
<211> 322
<212> DNA
<213> Gallus gallus

<400> 21
gcgctgactc agcctgcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc 60
tccggggatg gcagctatgc tggaagttac tattatggct ggtaccagca gaaggcacct 120
ggcagtgccc ctgtcactct gatctattac aacaacaaga gaccctcgga catcccttca 180
cgattctccg gttccctatc cggctccaca aacacattaa ccatcactgg ggtccgagcc 240
gatgacgagg ctgtctattt ctgtgggagt gcagacaaca gtggtgctgc atttggggcc 300
gggacaaccc tgacagtact tg                                          322

<210> 22
<211> 325
<212> DNA
<213> Gallus gallus

<400> 22
gcgctgactc agcctgcctc ggtgtcagca aacccaggag aaaccgtcaa gatcacctgc 60
tccgggagtg acagcagcta tgctggaagt tactattatg gctggtacca gcagaaggca 120
cctggcagtg cccctgtcac tctgatctat tacaacaaca agagaccctc ggacatccct 180
tcacgattct ccggttccct atccggctcc acaaacacat taaccatcac tggggtccga 240
gccgatgacg aggctgtcta tttctgtggg agtgcagaca acagtggtgc tgcatttggg 300
gccgggacaa ccctgacagt acttg                                       325

<210> 23
<211> 375
<212> DNA
<213> Gallus gallus

<400> 23
gccgtgacgt tggacgagtc cgggggcggc ctccagacgc ccgggggagc gctcagcctc 60
gtctgcaagg cctccgggtt caccttcagc agtaacgcca tgggttgggt gcgacaggcg 120
cccggcaagg ggctggagtg ggtcgctggt attgatgatg atggtagtgg cacaagatac 180
gcgccggcgg tgaagggccg tgccaccatc tcgagggaca acgggcagag cacactgagg 240
ctgcagctga acaacctcag ggctgaggac accggcacct actactgcac gaaatgtgct 300
tacagtagtg gttgtgatta tgaaggtggt tatatcgacg catggggcca cgggaccgaa 360
gtcatcgtct cctcc                                                  375

<210> 24
<211> 322
<212> DNA
<213> Gallus gallus

<400> 24
gcgctgactc agccggcctc ggtgtcagca aacctgggag gaaccgtcaa gatcacctgc 60
tccgggggtg gcagctatgc tggaagttac tattatggct ggtaccagca gaagtctcct 120
ggcagtgccc ctgtcactgt gatctatgac aacgacaaga gaccctcgga catcccttca 180
cgattctccg gttccctatc cggctccaca aacacattaa ccatcactgg ggtccgagcc 240
gatgacgagg ctgtctattt ctgtgggagt gcagacaaca gtggtgctgc atttggggcc 300
gggacaaccc tgaccgtcct ag                                          322

<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycine-serine polymer linker

<400> 25
Gly Ser Gly Gly Ser
 1               5  


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycine-serine polymer linker

<400> 26
Gly Gly Gly Gly Ser
 1               5  


<210> 27
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycine-serine polymer linker

<400> 27
Gly Gly Gly Ser
 1              


<210> 28
<211> 581
<212> PRT
<213> Homo sapiens

<400> 28
Met Gln Arg Pro Gly Pro Arg Leu Trp Leu Val Leu Gln Val Met Gly
 1               5                  10                  15      
Ser Cys Ala Ala Ile Ser Ser Met Asp Met Glu Arg Pro Gly Asp Gly
            20                  25                  30          
Lys Cys Gln Pro Ile Glu Ile Pro Met Cys Lys Asp Ile Gly Tyr Asn
        35                  40                  45              
Met Thr Arg Met Pro Asn Leu Met Gly His Glu Asn Gln Arg Glu Ala
    50                  55                  60                  
Ala Ile Gln Leu His Glu Phe Ala Pro Leu Val Glu Tyr Gly Cys His
65                  70                  75                  80  
Gly His Leu Arg Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr
                85                  90                  95      
Glu Gln Val Ser Thr Pro Ile Pro Ala Cys Arg Val Met Cys Glu Gln
            100                 105                 110         
Ala Arg Leu Lys Cys Ser Pro Ile Met Glu Gln Phe Asn Phe Lys Trp
        115                 120                 125             
Pro Asp Ser Leu Asp Cys Arg Lys Leu Pro Asn Lys Asn Asp Pro Asn
    130                 135                 140                 
Tyr Leu Cys Met Glu Ala Pro Asn Asn Gly Ser Asp Glu Pro Thr Arg
145                 150                 155                 160 
Gly Ser Gly Leu Phe Pro Pro Leu Phe Arg Pro Gln Arg Pro His Ser
                165                 170                 175     
Ala Gln Glu His Pro Leu Lys Asp Gly Gly Pro Gly Arg Gly Gly Cys
            180                 185                 190         
Asp Asn Pro Gly Lys Phe His His Val Glu Lys Ser Ala Ser Cys Ala
        195                 200                 205             
Pro Leu Cys Thr Pro Gly Val Asp Val Tyr Trp Ser Arg Glu Asp Lys
    210                 215                 220                 
Arg Phe Ala Val Val Trp Leu Ala Ile Trp Ala Val Leu Cys Phe Phe
225                 230                 235                 240 
Ser Ser Ala Phe Thr Val Leu Thr Phe Leu Ile Asp Pro Ala Arg Phe
                245                 250                 255     
Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met Cys Tyr Cys Val
            260                 265                 270         
Tyr Ser Val Gly Tyr Leu Ile Arg Leu Phe Ala Gly Ala Glu Ser Ile
        275                 280                 285             
Ala Cys Asp Arg Asp Ser Gly Gln Leu Tyr Val Ile Gln Glu Gly Leu
    290                 295                 300                 
Glu Ser Thr Gly Cys Thr Leu Val Phe Leu Val Leu Tyr Tyr Phe Gly
305                 310                 315                 320 
Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu Thr Trp Phe Leu
                325                 330                 335     
Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Ser
            340                 345                 350         
Tyr Phe His Leu Ala Ala Trp Ala Ile Pro Ala Val Lys Thr Ile Leu
        355                 360                 365             
Ile Leu Val Met Arg Arg Val Ala Gly Asp Glu Leu Thr Gly Val Cys
    370                 375                 380                 
Tyr Val Gly Ser Met Asp Val Asn Ala Leu Thr Gly Phe Val Leu Ile
385                 390                 395                 400 
Pro Leu Ala Cys Tyr Leu Val Ile Gly Thr Ser Phe Ile Leu Ser Gly
                405                 410                 415     
Phe Val Ala Leu Phe His Ile Arg Arg Val Met Lys Thr Gly Gly Glu
            420                 425                 430         
Asn Thr Asp Lys Leu Glu Lys Leu Met Val Arg Ile Gly Leu Phe Ser
        435                 440                 445             
Val Leu Tyr Thr Val Pro Ala Thr Cys Val Ile Ala Cys Tyr Phe Tyr
    450                 455                 460                 
Glu Arg Leu Asn Met Asp Tyr Trp Lys Ile Leu Ala Ala Gln His Lys
465                 470                 475                 480 
Cys Lys Met Asn Asn Gln Thr Lys Thr Leu Asp Cys Leu Met Ala Ala
                485                 490                 495     
Ser Ile Pro Ala Val Glu Ile Phe Met Val Lys Ile Phe Met Leu Leu
            500                 505                 510         
Val Val Gly Ile Thr Ser Gly Met Trp Ile Trp Thr Ser Lys Thr Leu
        515                 520                 525             
Gln Ser Trp Gln Gln Val Cys Ser Arg Arg Leu Lys Lys Lys Ser Arg
    530                 535                 540                 
Arg Lys Pro Ala Ser Val Ile Thr Ser Gly Gly Ile Tyr Lys Lys Ala
545                 550                 555                 560 
Gln His Pro Gln Lys Thr His His Gly Lys Tyr Glu Ile Pro Ala Gln
                565                 570                 575     
Ser Pro Thr Cys Val
            580     


<210> 29
<211> 212
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized L9.3 light chain with human lambda light
      chain constant region

<400> 29
Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala
 1               5                  10                  15      
Arg Ile Thr Cys Ser Gly Asp Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr
            20                  25                  30          
Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Leu Ile Tyr
        35                  40                  45              
Tyr Asn Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ala Asp Asn Ser Gly Ala Ala
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala
            100                 105                 110         
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn
        115                 120                 125             
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val
    130                 135                 140                 
Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu
145                 150                 155                 160 
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser
                165                 170                 175     
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser
            180                 185                 190         
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro
        195                 200                 205             
Thr Glu Cys Ser
    210         


<210> 30
<211> 696
<212> DNA
<213> Artificial Sequence

<220> 
<223> Coding sequence for humanized L9.3 light chain

<400> 30
atggcctgga ttcctctact tctccccctc ctcactctct gcacaggatc cgaggccgag 60
ttgacgcagc ccccgtcagt ctcggtgagc cccggacaaa cagcaaggat tacttgttcg 120
ggggatggct catatgctgg ttcctactat tacgggtggt atcaacagaa accggggcag 180
gcccctgtga ccctcatcta ctacaacaat aagcgcccat caggaatccc cgaacggttt 240
agcggttcgc ttagcggatc gacgaatacg ctcactatct ccggagtaca ggcggaggac 300
gaagccgact attactgcgg gtccgcggat aactcgggag cggcattcgg gggtggcacc 360
aagctgacag tcttgggtca gcccaaggct gccccctcgg tcaccctgtt cccgccctcc 420
tctgaggagc ttcaagccaa caaggccaca ctggtgtgtc tcataagtga cttctacccg 480
ggagccgtga cagtggcctg gaaggcagat agcagccccg tcaaggcggg agtggagacc 540
accacaccct ccaaacaaag caacaacaag tacgcggcca gcagctatct gagcctgacg 600
cctgagcagt ggaagtccca cagaagctac agctgccagg tcacgcatga agggagcacc 660
gtggagaaga cagtggcccc tacagaatgt tcatag                           696

<210> 31
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized B9 heavy chain with human IgG1 constant
      region

<400> 31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Tyr Pro Asn Tyr Gly Ser Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Ser Gly Tyr Gly Gly Ser Trp Gly Gly Tyr Ile Ala Asp Asp
            100                 105                 110         
Ile Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser
        115                 120                 125             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
    130                 135                 140                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
145                 150                 155                 160 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
                165                 170                 175     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
            180                 185                 190         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
        195                 200                 205             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
    210                 215                 220                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
225                 230                 235                 240 
Pro Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro
                245                 250                 255     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            260                 265                 270         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
        275                 280                 285             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    290                 295                 300                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
305                 310                 315                 320 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
                325                 330                 335     
Leu Pro Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
            340                 345                 350         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
        355                 360                 365             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
    370                 375                 380                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
385                 390                 395                 400 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
                405                 410                 415     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
            420                 425                 430         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
        435                 440                 445             
Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455     


<210> 32
<211> 1428
<212> DNA
<213> Artificial Sequence

<220> 
<223> Coding sequence for humanized B9 heavy chain

<400> 32
atggagttcg gcctgagctg gctgttcctg gtggccatcc ttaagggcgt gcagtgcgag 60
gtacagctcg tggaatcagg tggagggctt gtccaacccg gagggtcctt gcgcctgtcg 120
tgtgcggcct ccggtttcac gttttccagc ttcaatatgt tttgggtccg gcaggcaccg 180
ggtaaagggt tggaatgggt agcgggaatc gatgatgacg gctcgtatcc taattacggg 240
tcagctgtga aaggacgagc caccatcagc agagataact cgaagaacac actctacctt 300
caaatgaact cactgagggc agaggacacg gcggtgtact actgcgccaa gtcgggatat 360
gggggctcat ggggaggcta tattgcggac gacatcgatg cgtggggaca ggggacattg 420
gtcactgtga gctcggctag caccaagggc ccatcggtct tccccctggc accctcctcc 480
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa 540
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct 600
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc 660
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac 720
aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct 780
gaactcctgg ggggaccgga cgtcttcctc ttccccccaa aacccaagga caccctcatg 840
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 900
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 960
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1020
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccgag 1080
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 1140
ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc 1200
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 1260
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg 1320
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 1380
cacaaccact acacacagaa gagcctctcc ctgtctccgg gtaaatga              1428

<210> 33
<211> 993
<212> DNA
<213> Homo sapiens

<400> 33
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc 300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 720
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 900
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca 960
cagaagagcc tctccctgtc tccgggtaaa tga                              993

<210> 34
<211> 330
<212> PRT
<213> Homo sapiens

<400> 34
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 35
<211> 321
<212> DNA
<213> Homo sapiens

<400> 35
ggtcagccca aggctgcccc ctcggtcacc ctgttcccgc cctcctctga ggagcttcaa 60
gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg 120
gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa 180
caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag 240
tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg 300
gcccctacag aatgttcata g                                           321

<210> 36
<211> 106
<212> PRT
<213> Homo sapiens

<400> 36
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
        35                  40                  45              
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
                85                  90                  95      
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
            100                 105     


<210> 37
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized L9.3 light chain variable region

<400> 37
Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala
 1               5                  10                  15      
Arg Ile Thr Cys Ser Gly Asp Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr
            20                  25                  30          
Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Leu Ile Tyr
        35                  40                  45              
Tyr Asn Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Ser Gly Val Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ala Asp Asn Ser Gly Ala Ala
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105     


<210> 38
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human V lambda subgroup III consensus sequence
      with CDR amino acids denoted by Xaa

<220> 
<221> VARIANT        
<222> 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 51, 52,
53, 54, 55, 56, 57, 90, 91, 92, 93, 94, 95, 96, 97, 98
<223> Xaa = Any Amino Acid

<400> 38
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val
        35                  40                  45              
Ile Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Ile Pro Glu Arg Phe Ser
    50                  55                  60                  
Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Gln
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                85                  90                  95      
Xaa Xaa Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 39
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized B9 heavy chain variable region

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Asp Asp Asp Gly Ser Tyr Pro Asn Tyr Gly Ser Ala Val
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Ser Gly Tyr Gly Gly Ser Trp Gly Gly Tyr Ile Ala Asp Asp
            100                 105                 110         
Ile Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     


<210> 40
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human VH subgroup III consensus sequence with CDR
      amino acids denoted by Xaa

<220> 
<221> VARIANT        
<222> 31, 32, 33, 34, 35, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,
60, 61, 62, 63, 64, 65, 66, 99, 100, 101, 102, 103, 104,
105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115
<223> Xaa = Any Amino Acid

<400> 40
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     

