                         SEQUENCE LISTING

<110>  ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
 
<120>  MITOCHONDRIAL RIBOSOMAL PROTEINS AS AGING REGULATORS

<130>  p1450pc00

<150>  US 61/524,889
<151>  2011-08-18

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Thr Ala Val Arg Ala Val Gly Cys Leu Pro Val Leu Cys Ser 
1               5                   10                  15      


Gly Thr Ala Gly His Leu Leu Gly Arg Gln Cys Ser Leu Asn Thr Leu 
            20                  25                  30          


Pro Ala Ala Ser Ile Leu Ala Trp Lys Ser Val Leu Gly Asn Gly His 
        35                  40                  45              


Leu Ser Ser Leu Gly Thr Arg Asp Thr His Pro Tyr Ala Ser Leu Ser 
    50                  55                  60                  


Arg Ala Leu Gln Thr Gln Cys Cys Ile Ser Ser Pro Ser His Leu Met 
65                  70                  75                  80  


Ser Gln Gln Tyr Arg Pro Tyr Ser Phe Phe Thr Lys Leu Thr Ala Asp 
                85                  90                  95      


Glu Leu Trp Lys Gly Ala Leu Ala Glu Thr Gly Ala Gly Ala Lys Lys 
            100                 105                 110         


Gly Arg Gly Lys Arg Thr Lys Lys Lys Lys Arg Lys Asp Leu Asn Arg 
        115                 120                 125             


Gly Gln Ile Ile Gly Glu Gly Arg Tyr Gly Phe Leu Trp Pro Gly Leu 
    130                 135                 140                 


Asn Val Pro Leu Met Lys Asn Gly Ala Val Gln Thr Ile Ala Gln Arg 
145                 150                 155                 160 


Ser Lys Glu Glu Gln Glu Lys Val Glu Ala Asp Met Ile Gln Gln Arg 
                165                 170                 175     


Glu Glu Trp Asp Arg Lys Lys Lys Met Lys Val Lys Arg Glu Arg Gly 
            180                 185                 190         


Trp Ser Gly Asn Ser Trp Gly Gly Ile Ser Leu Gly Pro Pro Asp Pro 
        195                 200                 205             


Gly Pro Cys Gly Glu Thr Tyr Glu Asp Phe Asp Thr Arg Ile Leu Glu 
    210                 215                 220                 


Val Arg Asn Val Phe Thr Met Thr Ala Lys Glu Gly Arg Lys Lys Ser 
225                 230                 235                 240 


Ile Arg Val Leu Val Ala Val Gly Asn Gly Lys Gly Ala Ala Gly Phe 
                245                 250                 255     


Ser Ile Gly Lys Ala Thr Asp Arg Met Asp Ala Phe Arg Lys Ala Lys 
            260                 265                 270         


Asn Arg Ala Val His His Leu His Tyr Ile Glu Arg Tyr Glu Asp His 
        275                 280                 285             


Thr Ile Phe His Asp Ile Ser Leu Arg Phe Lys Arg Thr His Ile Lys 
    290                 295                 300                 


Met Lys Lys Gln Pro Lys Gly Tyr Gly Leu Arg Cys His Arg Ala Ile 
305                 310                 315                 320 


Ile Thr Ile Cys Arg Leu Ile Gly Ile Lys Asp Met Tyr Ala Lys Val 
                325                 330                 335     


Ser Gly Ser Ile Asn Met Leu Ser Leu Thr Gln Gly Leu Phe Arg Gly 
            340                 345                 350         


Leu Ser Arg Gln Glu Thr His Gln Gln Leu Ala Asp Lys Lys Gly Leu 
        355                 360                 365             


His Val Val Glu Ile Arg Glu Glu Cys Gly Pro Leu Pro Ile Val Val 
    370                 375                 380                 


Ala Ser Pro Arg Gly Pro Leu Arg Lys Asp Pro Glu Pro Glu Asp Glu 
385                 390                 395                 400 


Val Pro Asp Val Lys Leu Asp Trp Glu Asp Val Lys Thr Ala Gln Gly 
                405                 410                 415     


Met Lys Arg Ser Val Trp Ser Asn Leu Lys Arg Ala Ala Thr 
            420                 425                 430 


<210>  2
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ala Val Arg Cys Met Gly Arg Ala Leu Ile His His Gln 
1               5                   10                  15      


Arg His Ser Leu Ser Lys Met Val Tyr Gln Thr Ser Leu Cys Ser Cys 
            20                  25                  30          


Ser Val Asn Ile Arg Val Pro Asn Arg His Phe Ala Ala Ala Thr Lys 
        35                  40                  45              


Ser Ala Lys Lys Thr Lys Lys Gly Ala Lys Glu Lys Thr Pro Asp Glu 
    50                  55                  60                  


Lys Lys Asp Glu Ile Glu Lys Ile Lys Ala Tyr Pro Tyr Met Glu Gly 
65                  70                  75                  80  


Glu Pro Glu Asp Asp Val Tyr Leu Lys Arg Leu Tyr Pro Arg Gln Ile 
                85                  90                  95      


Tyr Glu Val Glu Lys Ala Val His Leu Leu Lys Lys Phe Gln Ile Leu 
            100                 105                 110         


Asp Phe Thr Ser Pro Lys Gln Ser Val Tyr Leu Asp Leu Thr Leu Asp 
        115                 120                 125             


Met Ala Leu Gly Lys Lys Lys Asn Val Glu Pro Phe Thr Ser Val Leu 
    130                 135                 140                 


Ser Leu Pro Tyr Pro Phe Ala Ser Glu Ile Asn Lys Val Ala Val Phe 
145                 150                 155                 160 


Thr Glu Asn Ala Ser Glu Val Lys Ile Ala Glu Glu Asn Gly Ala Ala 
                165                 170                 175     


Phe Ala Gly Gly Thr Ser Leu Ile Gln Lys Ile Trp Asp Asp Glu Ile 
            180                 185                 190         


Val Ala Asp Phe Tyr Val Ala Val Pro Glu Ile Met Pro Glu Leu Asn 
        195                 200                 205             


Arg Leu Arg Lys Lys Leu Asn Lys Lys Tyr Pro Lys Leu Ser Arg Asn 
    210                 215                 220                 


Ser Ile Gly Arg Asp Ile Pro Lys Met Leu Glu Leu Phe Lys Asn Gly 
225                 230                 235                 240 


His Glu Ile Lys Val Asp Glu Glu Arg Glu Asn Phe Leu Gln Thr Lys 
                245                 250                 255     


Ile Ala Thr Leu Asp Met Ser Ser Asp Gln Ile Ala Ala Asn Leu Gln 
            260                 265                 270         


Ala Val Ile Asn Glu Val Cys Arg His Arg Pro Leu Asn Leu Gly Pro 
        275                 280                 285             


Phe Val Val Arg Ala Phe Leu Arg Ser Ser Thr Ser Glu Gly Leu Leu 
    290                 295                 300                 


Leu Lys Ile Asp Pro Leu Leu Pro Lys Glu Val Lys Asn Glu Glu Ser 
305                 310                 315                 320 


Glu Lys Glu Asp Ala 
                325 


<210>  3
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Leu Cys Ala Leu Thr Arg Ala Leu Arg Ser Leu Asn Leu Ala 
1               5                   10                  15      


Pro Pro Thr Val Ala Ala Pro Ala Pro Ser Leu Phe Pro Ala Ala Gln 
            20                  25                  30          


Met Met Asn Asn Gly Leu Leu Gln Gln Pro Ser Ala Leu Met Leu Leu 
        35                  40                  45              


Pro Cys Arg Pro Val Leu Thr Ser Val Ala Leu Asn Ala Asn Phe Val 
    50                  55                  60                  


Ser Trp Lys Ser Arg Thr Lys Tyr Thr Ile Thr Pro Val Lys Met Arg 
65                  70                  75                  80  


Lys Ser Gly Gly Arg Asp His Thr Gly Arg Ile Arg Val His Gly Ile 
                85                  90                  95      


Gly Gly Gly His Lys Gln Arg Tyr Arg Met Ile Asp Phe Leu Arg Phe 
            100                 105                 110         


Arg Pro Glu Glu Thr Lys Ser Gly Pro Phe Glu Glu Lys Val Ile Gln 
        115                 120                 125             


Val Arg Tyr Asp Pro Cys Arg Ser Ala Asp Ile Ala Leu Val Ala Gly 
    130                 135                 140                 


Gly Ser Arg Lys Arg Trp Ile Ile Ala Thr Glu Asn Met Gln Ala Gly 
145                 150                 155                 160 


Asp Thr Ile Leu Asn Ser Asn His Ile Gly Arg Met Ala Val Ala Ala 
                165                 170                 175     


Arg Glu Gly Asp Ala His Pro Leu Gly Ala Leu Pro Val Gly Thr Leu 
            180                 185                 190         


Ile Asn Asn Val Glu Ser Glu Pro Gly Arg Gly Ala Gln Tyr Ile Arg 
        195                 200                 205             


Ala Ala Gly Thr Cys Gly Val Leu Leu Arg Lys Val Asn Gly Thr Ala 
    210                 215                 220                 


Ile Ile Gln Leu Pro Ser Lys Arg Gln Met Gln Val Leu Glu Thr Cys 
225                 230                 235                 240 


Val Ala Thr Val Gly Arg Val Ser Asn Val Asp His Asn Lys Arg Val 
                245                 250                 255     


Ile Gly Lys Ala Gly Arg Asn Arg Trp Leu Gly Lys Arg Pro Asn Ser 
            260                 265                 270         


Gly Arg Trp His Arg Lys Gly Gly Trp Ala Gly Arg Lys Ile Arg Pro 
        275                 280                 285             


Leu Pro Pro Met Lys Ser Tyr Val Lys Leu Pro Ser Ala Ser Ala Gln 
    290                 295                 300                 


Ser 
305 


<210>  4
<211>  432
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Ala Ala Val Arg Ala Ala Gly Cys Leu Pro Ala Leu Cys Ser 
1               5                   10                  15      


Leu Gln Ala Gly His Phe Leu Ser Arg Gln Leu Ser Leu Asn Ala Phe 
            20                  25                  30          


Pro Val Ala Ala Thr Ser Phe Leu Ala Val Lys Thr Ala Leu Ser His 
        35                  40                  45              


Gly Ser Leu Ser Ser Arg Glu Thr Arg Arg Asn His Cys Leu Thr Ser 
    50                  55                  60                  


Leu Ser His Val Leu Gln Thr Gln Cys Cys Val Ser Ser Pro Gly Asn 
65                  70                  75                  80  


Trp Thr Gly Gln Gln Cys Arg Pro Tyr Ser Phe Phe Thr Lys Leu Thr 
                85                  90                  95      


Ala Glu Glu Leu Trp Lys Gly Ala Leu Ala Glu Thr Gly Ala Gly Ala 
            100                 105                 110         


Arg Lys Gly Arg Gly Lys Arg Thr Lys Lys Lys Lys Arg Lys Asp Leu 
        115                 120                 125             


Asn Arg Gly Gln Ile Ile Gly Glu Gly Arg Ser Gly Phe Leu Trp Pro 
    130                 135                 140                 


Gly Leu Asn Val Pro Leu Ile Lys Ser Gly Val Val Gln Asn Ile Gly 
145                 150                 155                 160 


Gln Arg Ser Lys Glu Glu Gln Gln Lys Val Glu Ala Thr Met Val Glu 
                165                 170                 175     


Gln Arg Glu Glu Trp Asp Arg Lys Arg Lys Ile Lys Val Lys Arg Glu 
            180                 185                 190         


Arg Gly Trp Ser Gly Asn Thr Trp Gly Gly Val Ser Ile Gly Pro Pro 
        195                 200                 205             


Asp Pro Gly Pro Asn Gly Glu Thr Tyr Glu Asp Phe Asp Thr Arg Ile 
    210                 215                 220                 


Leu Glu Val Arg Asn Val Phe Asn Met Thr Ala Lys Glu Gly Arg Lys 
225                 230                 235                 240 


Lys Ser Val Arg Val Leu Val Ala Val Gly Asn Gly Asn Gly Ala Ala 
                245                 250                 255     


Gly Phe Ala Ile Gly Lys Ala Ala Asp Arg Gly Asp Ala Phe Arg Lys 
            260                 265                 270         


Ala Lys Asn Arg Ala Ile His Tyr Leu His Tyr Ile Glu Arg Tyr Glu 
        275                 280                 285             


Gly His Thr Ile Phe His Asp Ile Ser Leu Arg Phe Lys Arg Thr Gln 
    290                 295                 300                 


Ile Arg Met Lys Lys Gln Pro Arg Gly Tyr Gly Leu Arg Cys His Arg 
305                 310                 315                 320 


Ala Ile Ile Thr Ile Cys Arg Leu Ile Gly Ile Lys Asp Met Tyr Ala 
                325                 330                 335     


Arg Val Thr Gly Ser Met Asn Met Leu Asn Leu Thr Arg Gly Leu Phe 
            340                 345                 350         


His Gly Leu Ala Arg Gln Glu Thr His Gln His Leu Ala Asp Lys Lys 
        355                 360                 365             


Gly Leu His Val Val Glu Phe Arg Glu Glu Cys Gly Pro Leu Pro Ile 
    370                 375                 380                 


Val Val Ala Ser Pro His Gly Ala Leu Ser Lys Glu Pro Glu Pro Glu 
385                 390                 395                 400 


Pro Glu Val Pro Asp Thr Lys Leu Asp Trp Gln Asp Val Lys Ala Met 
                405                 410                 415     


Gln Gly Leu Lys Arg Ser Val Trp Phe Asn Leu Lys Arg Pro Ala Thr 
            420                 425                 430         


<210>  5
<211>  336
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Ala Ala Val Arg Cys Leu Arg Arg Val Leu Ile His His Gln 
1               5                   10                  15      


Arg His Cys Leu Cys Lys Met Ala Ser Gln Ala Ser Leu Tyr Pro Cys 
            20                  25                  30          


Ser Val Asn Ser Leu Leu His Asn Arg His Phe Ala Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Thr Lys Pro Ala Arg Lys Ile Lys Lys Gly Ala Lys Glu Lys 
    50                  55                  60                  


Thr Ser Asp Glu Lys Pro Val Asp Asp Ile Glu Lys Ile Lys Ser Tyr 
65                  70                  75                  80  


Thr Tyr Met Glu Ser Asp Pro Glu Asp Asp Val Tyr Leu Lys Arg Leu 
                85                  90                  95      


Tyr Pro Arg Arg Ile Tyr Glu Val Glu Lys Ala Ile His Leu Leu Lys 
            100                 105                 110         


Lys Phe Gln Val Leu Asp Phe Thr Asn Pro Lys Gln Gly Val Tyr Leu 
        115                 120                 125             


Asp Leu Thr Leu Asp Met Ala Leu Gly Lys Lys Lys Thr Val Glu Pro 
    130                 135                 140                 


Phe Ala Ser Val Ile Ala Leu Pro His Leu Phe Ser Ser Glu Val Asn 
145                 150                 155                 160 


Lys Val Ala Val Phe Thr Ala Asn Ala Ser Glu Ile Lys Ile Ala Glu 
                165                 170                 175     


Glu Asn Gly Ala Ala Phe Ala Gly Gly Thr Asp Leu Val Lys Lys Ile 
            180                 185                 190         


Met Asp Asp Glu Val Val Val Asp Phe Tyr Val Ala Val Pro Glu Ile 
        195                 200                 205             


Met Gly Glu Leu Asn Pro Leu Arg Lys Lys Leu Lys Lys Arg Phe Pro 
    210                 215                 220                 


Lys Ala Thr Arg Asn Ser Ile Gly Arg Asp Ile Pro Lys Met Leu Glu 
225                 230                 235                 240 


Leu Phe Lys Thr Ala His Glu Ile Met Val Asp Glu Glu Arg Gln Asn 
                245                 250                 255     


Phe Leu Ser Thr Lys Ile Ala Thr Leu Asp Met Pro Ser Asp Gln Ile 
            260                 265                 270         


Ala Ala Asn Leu Gln Ala Val Ile Asn Glu Val Cys Lys His Arg Pro 
        275                 280                 285             


Leu Asn Leu Gly Pro Phe Val Val Arg Ala Phe Leu Arg Ser Ser Thr 
    290                 295                 300                 


Ser Glu Gly Leu Leu Leu Lys Thr Asp Ser Leu Leu Pro Lys Glu Ala 
305                 310                 315                 320 


Lys Thr Thr Glu Ala Glu Thr Glu Glu Thr Gln Thr Ala Glu Ala Ala 
                325                 330                 335     


<210>  6
<211>  306
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Leu Cys Ala Leu Thr Ser Ala Leu Arg Ser Leu Ser Leu Ala 
1               5                   10                  15      


Ser Ala Ala Ile Thr Ala Arg Val Pro Thr Leu Leu Pro Ala Ala Gln 
            20                  25                  30          


Ile Gln Ser Asn Val Leu Leu Gln Leu Pro Pro Ala Leu Val Ser Pro 
        35                  40                  45              


Ser Tyr Arg Pro Val His Met Ser Ala Asp Arg Ser Ala Lys Phe Val 
    50                  55                  60                  


Ser Trp Lys Ser Arg Thr Lys Tyr Thr Val Lys Pro Val Lys Met Arg 
65                  70                  75                  80  


Lys Ser Gly Gly Arg Asp His Thr Gly Arg Ile Arg Val His Gly Ile 
                85                  90                  95      


Gly Gly Gly His Lys Gln Asn Tyr Arg Met Ile Asp Phe Leu Arg Phe 
            100                 105                 110         


Arg Pro Glu Lys Glu Lys Ala Pro Glu Pro Phe Glu Glu Lys Val Val 
        115                 120                 125             


Val Val Arg Tyr Asp Pro Cys Arg Ser Ala Asp Ile Ala Leu Val Ala 
    130                 135                 140                 


Gly Gly Ser Arg Lys Arg Trp Ile Ile Ala Thr Glu Asn Met Lys Ala 
145                 150                 155                 160 


Gly Asp Thr Ile Leu Asn Ser Asn His Ile Gly Arg Met Ala Val Ala 
                165                 170                 175     


Ala Gln Glu Gly Asp Ala His Pro Leu Gly Ala Leu Pro Val Gly Thr 
            180                 185                 190         


Leu Ile Asn Asn Val Glu Ser Glu Pro Gly Arg Gly Ala Gln Tyr Ile 
        195                 200                 205             


Arg Ala Ala Gly Thr Cys Gly Val Leu Leu Arg Lys Val Asn Gly Thr 
    210                 215                 220                 


Ala Ile Ile Gln Leu Pro Ser Lys Arg Gln Met Gln Val Leu Glu Ser 
225                 230                 235                 240 


Cys Thr Ala Thr Val Gly Arg Val Ser Asn Val Asn His Asn Gln Arg 
                245                 250                 255     


Val Ile Gly Lys Ala Gly Arg Asn Arg Trp Leu Gly Lys Arg Pro Asn 
            260                 265                 270         


Ser Gly Leu Trp Gln Arg Lys Gly Gly Trp Ala Gly Arg Lys Ile Arg 
        275                 280                 285             


Pro Leu Pro Pro Met Lys Ser Tyr Val Lys Leu Pro Ser Ala Ala Ala 
    290                 295                 300                 


Gln Asn 
305     


<210>  7
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  7
gacaacgcgt aacaaaagag gggcgtcag                                         29


<210>  8
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  8
gacactcgag ccctgagaaa ccaagtcagc                                        30


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  9
gacaacgcgt ctttccggtc tgatctccag                                        30


<210>  10
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  10
gacactcgag gtaccgtctg ctccaccac                                         29


