﻿               SEQUENCE LISTING

<110> Evotec (Muenchen) GmbH

<120> Markers for susceptibility to an inhibitor of an Src-Family Kinase

<130> T2616 PCT S3

<150> EP11 17 7711.6
<151> 2011-08-16
<150> EP11 17 7726.4
<151> 2011-08-16
<150> EP11 17 8024.3
<151> 2011-08-18
<150> EP12 16 7185.3
<151> 2012-05-08

<160> 21

<170> BiSSAP 1.0

<210> 1
<211> 5469
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..5469
<223> /db_xref=NCBI:NM_000213/gi54607034:188-5656
      /mol_type="DNA"
      /organism="Homo sapiens"

<400> 1
atggcagggc cacgccccag cccatgggcc aggctgctcc tggcagcctt gatcagcgtc       60

agcctctctg ggaccttggc aaaccgctgc aagaaggccc cagtgaagag ctgcacggag      120

tgtgtccgtg tggataagga ctgcgcctac tgcacagacg agatgttcag ggaccggcgc      180

tgcaacaccc aggcggagct gctggccgcg ggctgccagc gggagagcat cgtggtcatg      240

gagagcagct tccaaatcac agaggagacc cagattgaca ccaccctgcg gcgcagccag      300

atgtcccccc aaggcctgcg ggtccgtctg cggcccggtg aggagcggca ttttgagctg      360

gaggtgtttg agccactgga gagccccgtg gacctgtaca tcctcatgga cttctccaac      420

tccatgtccg atgatctgga caacctcaag aagatggggc agaacctggc tcgggtcctg      480

agccagctca ccagcgacta cactattgga tttggcaagt ttgtggacaa agtcagcgtc      540

ccgcagacgg acatgaggcc tgagaagctg aaggagccct ggcccaacag tgaccccccc      600

ttctccttca agaacgtcat cagcctgaca gaagatgtgg atgagttccg gaataaactg      660

cagggagagc ggatctcagg caacctggat gctcctgagg gcggcttcga tgccatcctg      720

cagacagctg tgtgcacgag ggacattggc tggcgcccgg acagcaccca cctgctggtc      780

ttctccaccg agtcagcctt ccactatgag gctgatggcg ccaacgtgct ggctggcatc      840

atgagccgca acgatgaacg gtgccacctg gacaccacgg gcacctacac ccagtacagg      900

acacaggact acccgtcggt gcccaccctg gtgcgcctgc tcgccaagca caacatcatc      960

cccatctttg ctgtcaccaa ctactcctat agctactacg agaagcttca cacctatttc     1020

cctgtctcct cactgggggt gctgcaggag gactcgtcca acatcgtgga gctgctggag     1080

gaggccttca atcggatccg ctccaacctg gacatccggg ccctagacag cccccgaggc     1140

cttcggacag aggtcacctc caagatgttc cagaagacga ggactgggtc ctttcacatc     1200

cggcgggggg aagtgggtat ataccaggtg cagctgcggg cccttgagca cgtggatggg     1260

acgcacgtgt gccagctgcc ggaggaccag aagggcaaca tccatctgaa accttccttc     1320

tccgacggcc tcaagatgga cgcgggcatc atctgtgatg tgtgcacctg cgagctgcaa     1380

aaagaggtgc ggtcagctcg ctgcagcttc aacggagact tcgtgtgcgg acagtgtgtg     1440

tgcagcgagg gctggagtgg ccagacctgc aactgctcca ccggctctct gagtgacatt     1500

cagccctgcc tgcgggaggg cgaggacaag ccgtgctccg gccgtgggga gtgccagtgc     1560

gggcactgtg tgtgctacgg cgaaggccgc tacgagggtc agttctgcga gtatgacaac     1620

ttccagtgtc cccgcacttc cgggttcctc tgcaatgacc gaggacgctg ctccatgggc     1680

cagtgtgtgt gtgagcctgg ttggacaggc ccaagctgtg actgtcccct cagcaatgcc     1740

acctgcatcg acagcaatgg gggcatctgt aatggacgtg gccactgtga gtgtggccgc     1800

tgccactgcc accagcagtc gctctacacg gacaccatct gcgagatcaa ctactcggcg     1860

atccacccgg gcctctgcga ggacctacgc tcctgcgtgc agtgccaggc gtggggcacc     1920

ggcgagaaga aggggcgcac gtgtgaggaa tgcaacttca aggtcaagat ggtggacgag     1980

cttaagagag ccgaggaggt ggtggtgcgc tgctccttcc gggacgagga tgacgactgc     2040

acctacagct acaccatgga aggtgacggc gcccctgggc ccaacagcac tgtcctggtg     2100

cacaagaaga aggactgccc tccgggctcc ttctggtggc tcatccccct gctcctcctc     2160

ctcctgccgc tcctggccct gctactgctg ctatgctgga agtactgtgc ctgctgcaag     2220

gcctgcctgg cacttctccc gtgctgcaac cgaggtcaca tggtgggctt taaggaagac     2280

cactacatgc tgcgggagaa cctgatggcc tctgaccact tggacacgcc catgctgcgc     2340

agcgggaacc tcaagggccg tgacgtggtc cgctggaagg tcaccaacaa catgcagcgg     2400

cctggctttg ccactcatgc cgccagcatc aaccccacag agctggtgcc ctacgggctg     2460

tccttgcgcc tggcccgcct ttgcaccgag aacctgctga agcctgacac tcgggagtgc     2520

gcccagctgc gccaggaggt ggaggagaac ctgaacgagg tctacaggca gatctccggt     2580

gtacacaagc tccagcagac caagttccgg cagcagccca atgccgggaa aaagcaagac     2640

cacaccattg tggacacagt gctgatggcg ccccgctcgg ccaagccggc cctgctgaag     2700

cttacagaga agcaggtgga acagagggcc ttccacgacc tcaaggtggc ccccggctac     2760

tacaccctca ctgcagacca ggacgcccgg ggcatggtgg agttccagga gggcgtggag     2820

ctggtggacg tacgggtgcc cctctttatc cggcctgagg atgacgacga gaagcagctg     2880

ctggtggagg ccatcgacgt gcccgcaggc actgccaccc tcggccgccg cctggtaaac     2940

atcaccatca tcaaggagca agccagagac gtggtgtcct ttgagcagcc tgagttctcg     3000

gtcagccgcg gggaccaggt ggcccgcatc cctgtcatcc ggcgtgtcct ggacggcggg     3060

aagtcccagg tctcctaccg cacacaggat ggcaccgcgc agggcaaccg ggactacatc     3120

cccgtggagg gtgagctgct gttccagcct ggggaggcct ggaaagagct gcaggtgaag     3180

ctcctggagc tgcaagaagt tgactccctc ctgcggggcc gccaggtccg ccgtttccac     3240

gtccagctca gcaaccctaa gtttggggcc cacctgggcc agccccactc caccaccatc     3300

atcatcaggg acccagatga actggaccgg agcttcacga gtcagatgtt gtcatcacag     3360

ccaccccctc acggcgacct gggcgccccg cagaacccca atgctaaggc cgctgggtcc     3420

aggaagatcc atttcaactg gctgccccct tctggcaagc caatggggta cagggtaaag     3480

tactggattc agggtgactc cgaatccgaa gcccacctgc tcgacagcaa ggtgccctca     3540

gtggagctca ccaacctgta cccgtattgc gactatgaga tgaaggtgtg cgcctacggg     3600

gctcagggcg agggacccta cagctccctg gtgtcctgcc gcacccacca ggaagtgccc     3660

agcgagccag ggcgtctggc cttcaatgtc gtctcctcca cggtgaccca gctgagctgg     3720

gctgagccgg ctgagaccaa cggtgagatc acagcctacg aggtctgcta tggcctggtc     3780

aacgatgaca accgacctat tgggcccatg aagaaagtgc tggttgacaa ccctaagaac     3840

cggatgctgc ttattgagaa ccttcgggag tcccagccct accgctacac ggtgaaggcg     3900

cgcaacgggg ccggctgggg gcctgagcgg gaggccatca tcaacctggc cacccagccc     3960

aagaggccca tgtccatccc catcatccct gacatcccta tcgtggacgc ccagagcggg     4020

gaggactacg acagcttcct tatgtacagc gatgacgttc tacgctctcc atcgggcagc     4080

cagaggccca gcgtctccga tgacactggc tgcggctgga agttcgagcc cctgctgggg     4140

gaggagctgg acctgcggcg cgtcacgtgg cggctgcccc cggagctcat cccgcgcctg     4200

tcggccagca gcgggcgctc ctccgacgcc gaggcgcccc acgggccccc ggacgacggc     4260

ggcgcgggcg ggaagggcgg cagcctgccc cgcagtgcga cacccgggcc ccccggagag     4320

cacctggtga atggccggat ggactttgcc ttcccgggca gcaccaactc cctgcacagg     4380

atgaccacga ccagtgctgc tgcctatggc acccacctga gcccacacgt gccccaccgc     4440

gtgctaagca catcctccac cctcacacgg gactacaact cactgacccg ctcagaacac     4500

tcacactcga ccacactgcc cagggactac tccaccctca cctccgtctc ctcccacgac     4560

tctcgcctga ctgctggtgt gcccgacacg cccacccgcc tggtgttctc tgccctgggg     4620

cccacatctc tcagagtgag ctggcaggag ccgcggtgcg agcggccgct gcagggctac     4680

agtgtggagt accagctgct gaacggcggt gagctgcatc ggctcaacat ccccaaccct     4740

gcccagacct cggtggtggt ggaagacctc ctgcccaacc actcctacgt gttccgcgtg     4800

cgggcccaga gccaggaagg ctggggccga gagcgtgagg gtgtcatcac cattgaatcc     4860

caggtgcacc cgcagagccc actgtgtccc ctgccaggct ccgccttcac tttgagcact     4920

cccagtgccc caggcccgct ggtgttcact gccctgagcc cagactcgct gcagctgagc     4980

tgggagcggc cacggaggcc caatggggat atcgtcggct acctggtgac ctgtgagatg     5040

gcccaaggag gagggccagc caccgcattc cgggtggatg gagacagccc cgagagccgg     5100

ctgaccgtgc cgggcctcag cgagaacgtg ccctacaagt tcaaggtgca ggccaggacc     5160

actgagggct tcgggccaga gcgcgagggc atcatcacca tagagtccca ggatggagga     5220

cccttcccgc agctgggcag ccgtgccggg ctcttccagc acccgctgca aagcgagtac     5280

agcagcatca ccaccaccca caccagcgcc accgagccct tcctagtgga tgggctgacc     5340

ctgggggccc agcacctgga ggcaggcggc tccctcaccc ggcatgtgac ccaggagttt     5400

gtgagccgga cactgaccac cagcggaacc cttagcaccc acatggacca acagttcttc     5460

caaacttga                                                             5469


<210> 2
<211> 5418
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..5418
<223> /db_xref=NCBI:NM_001005619/gi54607026:9-5426
      /mol_type="DNA"
      /organism="Homo sapiens"

<400> 2
atggcagggc cacgccccag cccatgggcc aggctgctcc tggcagcctt gatcagcgtc       60

agcctctctg ggaccttggc aaaccgctgc aagaaggccc cagtgaagag ctgcacggag      120

tgtgtccgtg tggataagga ctgcgcctac tgcacagacg agatgttcag ggaccggcgc      180

tgcaacaccc aggcggagct gctggccgcg ggctgccagc gggagagcat cgtggtcatg      240

gagagcagct tccaaatcac agaggagacc cagattgaca ccaccctgcg gcgcagccag      300

atgtcccccc aaggcctgcg ggtccgtctg cggcccggtg aggagcggca ttttgagctg      360

gaggtgtttg agccactgga gagccccgtg gacctgtaca tcctcatgga cttctccaac      420

tccatgtccg atgatctgga caacctcaag aagatggggc agaacctggc tcgggtcctg      480

agccagctca ccagcgacta cactattgga tttggcaagt ttgtggacaa agtcagcgtc      540

ccgcagacgg acatgaggcc tgagaagctg aaggagccct ggcccaacag tgaccccccc      600

ttctccttca agaacgtcat cagcctgaca gaagatgtgg atgagttccg gaataaactg      660

cagggagagc ggatctcagg caacctggat gctcctgagg gcggcttcga tgccatcctg      720

cagacagctg tgtgcacgag ggacattggc tggcgcccgg acagcaccca cctgctggtc      780

ttctccaccg agtcagcctt ccactatgag gctgatggcg ccaacgtgct ggctggcatc      840

atgagccgca acgatgaacg gtgccacctg gacaccacgg gcacctacac ccagtacagg      900

acacaggact acccgtcggt gcccaccctg gtgcgcctgc tcgccaagca caacatcatc      960

cccatctttg ctgtcaccaa ctactcctat agctactacg agaagcttca cacctatttc     1020

cctgtctcct cactgggggt gctgcaggag gactcgtcca acatcgtgga gctgctggag     1080

gaggccttca atcggatccg ctccaacctg gacatccggg ccctagacag cccccgaggc     1140

cttcggacag aggtcacctc caagatgttc cagaagacga ggactgggtc ctttcacatc     1200

cggcgggggg aagtgggtat ataccaggtg cagctgcggg cccttgagca cgtggatggg     1260

acgcacgtgt gccagctgcc ggaggaccag aagggcaaca tccatctgaa accttccttc     1320

tccgacggcc tcaagatgga cgcgggcatc atctgtgatg tgtgcacctg cgagctgcaa     1380

aaagaggtgc ggtcagctcg ctgcagcttc aacggagact tcgtgtgcgg acagtgtgtg     1440

tgcagcgagg gctggagtgg ccagacctgc aactgctcca ccggctctct gagtgacatt     1500

cagccctgcc tgcgggaggg cgaggacaag ccgtgctccg gccgtgggga gtgccagtgc     1560

gggcactgtg tgtgctacgg cgaaggccgc tacgagggtc agttctgcga gtatgacaac     1620

ttccagtgtc cccgcacttc cgggttcctc tgcaatgacc gaggacgctg ctccatgggc     1680

cagtgtgtgt gtgagcctgg ttggacaggc ccaagctgtg actgtcccct cagcaatgcc     1740

acctgcatcg acagcaatgg gggcatctgt aatggacgtg gccactgtga gtgtggccgc     1800

tgccactgcc accagcagtc gctctacacg gacaccatct gcgagatcaa ctactcggcg     1860

atccacccgg gcctctgcga ggacctacgc tcctgcgtgc agtgccaggc gtggggcacc     1920

ggcgagaaga aggggcgcac gtgtgaggaa tgcaacttca aggtcaagat ggtggacgag     1980

cttaagagag ccgaggaggt ggtggtgcgc tgctccttcc gggacgagga tgacgactgc     2040

acctacagct acaccatgga aggtgacggc gcccctgggc ccaacagcac tgtcctggtg     2100

cacaagaaga aggactgccc tccgggctcc ttctggtggc tcatccccct gctcctcctc     2160

ctcctgccgc tcctggccct gctactgctg ctatgctgga agtactgtgc ctgctgcaag     2220

gcctgcctgg cacttctccc gtgctgcaac cgaggtcaca tggtgggctt taaggaagac     2280

cactacatgc tgcgggagaa cctgatggcc tctgaccact tggacacgcc catgctgcgc     2340

agcgggaacc tcaagggccg tgacgtggtc cgctggaagg tcaccaacaa catgcagcgg     2400

cctggctttg ccactcatgc cgccagcatc aaccccacag agctggtgcc ctacgggctg     2460

tccttgcgcc tggcccgcct ttgcaccgag aacctgctga agcctgacac tcgggagtgc     2520

gcccagctgc gccaggaggt ggaggagaac ctgaacgagg tctacaggca gatctccggt     2580

gtacacaagc tccagcagac caagttccgg cagcagccca atgccgggaa aaagcaagac     2640

cacaccattg tggacacagt gctgatggcg ccccgctcgg ccaagccggc cctgctgaag     2700

cttacagaga agcaggtgga acagagggcc ttccacgacc tcaaggtggc ccccggctac     2760

tacaccctca ctgcagacca ggacgcccgg ggcatggtgg agttccagga gggcgtggag     2820

ctggtggacg tacgggtgcc cctctttatc cggcctgagg atgacgacga gaagcagctg     2880

ctggtggagg ccatcgacgt gcccgcaggc actgccaccc tcggccgccg cctggtaaac     2940

atcaccatca tcaaggagca agccagagac gtggtgtcct ttgagcagcc tgagttctcg     3000

gtcagccgcg gggaccaggt ggcccgcatc cctgtcatcc ggcgtgtcct ggacggcggg     3060

aagtcccagg tctcctaccg cacacaggat ggcaccgcgc agggcaaccg ggactacatc     3120

cccgtggagg gtgagctgct gttccagcct ggggaggcct ggaaagagct gcaggtgaag     3180

ctcctggagc tgcaagaagt tgactccctc ctgcggggcc gccaggtccg ccgtttccac     3240

gtccagctca gcaaccctaa gtttggggcc cacctgggcc agccccactc caccaccatc     3300

atcatcaggg acccagatga actggaccgg agcttcacga gtcagatgtt gtcatcacag     3360

ccaccccctc acggcgacct gggcgccccg cagaacccca atgctaaggc cgctgggtcc     3420

aggaagatcc atttcaactg gctgccccct tctggcaagc caatggggta cagggtaaag     3480

tactggattc agggtgactc cgaatccgaa gcccacctgc tcgacagcaa ggtgccctca     3540

gtggagctca ccaacctgta cccgtattgc gactatgaga tgaaggtgtg cgcctacggg     3600

gctcagggcg agggacccta cagctccctg gtgtcctgcc gcacccacca ggaagtgccc     3660

agcgagccag ggcgtctggc cttcaatgtc gtctcctcca cggtgaccca gctgagctgg     3720

gctgagccgg ctgagaccaa cggtgagatc acagcctacg aggtctgcta tggcctggtc     3780

aacgatgaca accgacctat tgggcccatg aagaaagtgc tggttgacaa ccctaagaac     3840

cggatgctgc ttattgagaa ccttcgggag tcccagccct accgctacac ggtgaaggcg     3900

cgcaacgggg ccggctgggg gcctgagcgg gaggccatca tcaacctggc cacccagccc     3960

aagaggccca tgtccatccc catcatccct gacatcccta tcgtggacgc ccagagcggg     4020

gaggactacg acagcttcct tatgtacagc gatgacgttc tacgctctcc atcgggcagc     4080

cagaggccca gcgtctccga tgacactgag cacctggtga atggccggat ggactttgcc     4140

ttcccgggca gcaccaactc cctgcacagg atgaccacga ccagtgctgc tgcctatggc     4200

acccacctga gcccacacgt gccccaccgc gtgctaagca catcctccac cctcacacgg     4260

gactacaact cactgacccg ctcagaacac tcacactcga ccacactgcc cagggactac     4320

tccaccctca cctccgtctc ctcccacggc ctccctccca tctgggaaca cgggaggagc     4380

aggcttccgc tgtcctgggc cctggggtcc cggagtcggg ctcagatgaa agggttcccc     4440

ccttccaggg gcccacgaga ctctataatc ctggctggga ggccagcagc gccctcctgg     4500

ggcccagact ctcgcctgac tgctggtgtg cccgacacgc ccacccgcct ggtgttctct     4560

gccctggggc ccacatctct cagagtgagc tggcaggagc cgcggtgcga gcggccgctg     4620

cagggctaca gtgtggagta ccagctgctg aacggcggtg agctgcatcg gctcaacatc     4680

cccaaccctg cccagacctc ggtggtggtg gaagacctcc tgcccaacca ctcctacgtg     4740

ttccgcgtgc gggcccagag ccaggaaggc tggggccgag agcgtgaggg tgtcatcacc     4800

attgaatccc aggtgcaccc gcagagccca ctgtgtcccc tgccaggctc cgccttcact     4860

ttgagcactc ccagtgcccc aggcccgctg gtgttcactg ccctgagccc agactcgctg     4920

cagctgagct gggagcggcc acggaggccc aatggggata tcgtcggcta cctggtgacc     4980

tgtgagatgg cccaaggagg agggccagcc accgcattcc gggtggatgg agacagcccc     5040

gagagccggc tgaccgtgcc gggcctcagc gagaacgtgc cctacaagtt caaggtgcag     5100

gccaggacca ctgagggctt cgggccagag cgcgagggca tcatcaccat agagtcccag     5160

gatggaggac ccttcccgca gctgggcagc cgtgccgggc tcttccagca cccgctgcaa     5220

agcgagtaca gcagcatcac caccacccac accagcgcca ccgagccctt cctagtggat     5280

gggctgaccc tgggggccca gcacctggag gcaggcggct ccctcacccg gcatgtgacc     5340

caggagtttg tgagccggac actgaccacc agcggaaccc ttagcaccca catggaccaa     5400

cagttcttcc aaacttga                                                   5418


<210> 3
<211> 5259
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..5259
<223> /db_xref=NCBI:NM_001005731/gi54607032:188-5446
      /mol_type="DNA"
      /organism="Homo sapiens"

<400> 3
atggcagggc cacgccccag cccatgggcc aggctgctcc tggcagcctt gatcagcgtc       60

agcctctctg ggaccttggc aaaccgctgc aagaaggccc cagtgaagag ctgcacggag      120

tgtgtccgtg tggataagga ctgcgcctac tgcacagacg agatgttcag ggaccggcgc      180

tgcaacaccc aggcggagct gctggccgcg ggctgccagc gggagagcat cgtggtcatg      240

gagagcagct tccaaatcac agaggagacc cagattgaca ccaccctgcg gcgcagccag      300

atgtcccccc aaggcctgcg ggtccgtctg cggcccggtg aggagcggca ttttgagctg      360

gaggtgtttg agccactgga gagccccgtg gacctgtaca tcctcatgga cttctccaac      420

tccatgtccg atgatctgga caacctcaag aagatggggc agaacctggc tcgggtcctg      480

agccagctca ccagcgacta cactattgga tttggcaagt ttgtggacaa agtcagcgtc      540

ccgcagacgg acatgaggcc tgagaagctg aaggagccct ggcccaacag tgaccccccc      600

ttctccttca agaacgtcat cagcctgaca gaagatgtgg atgagttccg gaataaactg      660

cagggagagc ggatctcagg caacctggat gctcctgagg gcggcttcga tgccatcctg      720

cagacagctg tgtgcacgag ggacattggc tggcgcccgg acagcaccca cctgctggtc      780

ttctccaccg agtcagcctt ccactatgag gctgatggcg ccaacgtgct ggctggcatc      840

atgagccgca acgatgaacg gtgccacctg gacaccacgg gcacctacac ccagtacagg      900

acacaggact acccgtcggt gcccaccctg gtgcgcctgc tcgccaagca caacatcatc      960

cccatctttg ctgtcaccaa ctactcctat agctactacg agaagcttca cacctatttc     1020

cctgtctcct cactgggggt gctgcaggag gactcgtcca acatcgtgga gctgctggag     1080

gaggccttca atcggatccg ctccaacctg gacatccggg ccctagacag cccccgaggc     1140

cttcggacag aggtcacctc caagatgttc cagaagacga ggactgggtc ctttcacatc     1200

cggcgggggg aagtgggtat ataccaggtg cagctgcggg cccttgagca cgtggatggg     1260

acgcacgtgt gccagctgcc ggaggaccag aagggcaaca tccatctgaa accttccttc     1320

tccgacggcc tcaagatgga cgcgggcatc atctgtgatg tgtgcacctg cgagctgcaa     1380

aaagaggtgc ggtcagctcg ctgcagcttc aacggagact tcgtgtgcgg acagtgtgtg     1440

tgcagcgagg gctggagtgg ccagacctgc aactgctcca ccggctctct gagtgacatt     1500

cagccctgcc tgcgggaggg cgaggacaag ccgtgctccg gccgtgggga gtgccagtgc     1560

gggcactgtg tgtgctacgg cgaaggccgc tacgagggtc agttctgcga gtatgacaac     1620

ttccagtgtc cccgcacttc cgggttcctc tgcaatgacc gaggacgctg ctccatgggc     1680

cagtgtgtgt gtgagcctgg ttggacaggc ccaagctgtg actgtcccct cagcaatgcc     1740

acctgcatcg acagcaatgg gggcatctgt aatggacgtg gccactgtga gtgtggccgc     1800

tgccactgcc accagcagtc gctctacacg gacaccatct gcgagatcaa ctactcggcg     1860

atccacccgg gcctctgcga ggacctacgc tcctgcgtgc agtgccaggc gtggggcacc     1920

ggcgagaaga aggggcgcac gtgtgaggaa tgcaacttca aggtcaagat ggtggacgag     1980

cttaagagag ccgaggaggt ggtggtgcgc tgctccttcc gggacgagga tgacgactgc     2040

acctacagct acaccatgga aggtgacggc gcccctgggc ccaacagcac tgtcctggtg     2100

cacaagaaga aggactgccc tccgggctcc ttctggtggc tcatccccct gctcctcctc     2160

ctcctgccgc tcctggccct gctactgctg ctatgctgga agtactgtgc ctgctgcaag     2220

gcctgcctgg cacttctccc gtgctgcaac cgaggtcaca tggtgggctt taaggaagac     2280

cactacatgc tgcgggagaa cctgatggcc tctgaccact tggacacgcc catgctgcgc     2340

agcgggaacc tcaagggccg tgacgtggtc cgctggaagg tcaccaacaa catgcagcgg     2400

cctggctttg ccactcatgc cgccagcatc aaccccacag agctggtgcc ctacgggctg     2460

tccttgcgcc tggcccgcct ttgcaccgag aacctgctga agcctgacac tcgggagtgc     2520

gcccagctgc gccaggaggt ggaggagaac ctgaacgagg tctacaggca gatctccggt     2580

gtacacaagc tccagcagac caagttccgg cagcagccca atgccgggaa aaagcaagac     2640

cacaccattg tggacacagt gctgatggcg ccccgctcgg ccaagccggc cctgctgaag     2700

cttacagaga agcaggtgga acagagggcc ttccacgacc tcaaggtggc ccccggctac     2760

tacaccctca ctgcagacca ggacgcccgg ggcatggtgg agttccagga gggcgtggag     2820

ctggtggacg tacgggtgcc cctctttatc cggcctgagg atgacgacga gaagcagctg     2880

ctggtggagg ccatcgacgt gcccgcaggc actgccaccc tcggccgccg cctggtaaac     2940

atcaccatca tcaaggagca agccagagac gtggtgtcct ttgagcagcc tgagttctcg     3000

gtcagccgcg gggaccaggt ggcccgcatc cctgtcatcc ggcgtgtcct ggacggcggg     3060

aagtcccagg tctcctaccg cacacaggat ggcaccgcgc agggcaaccg ggactacatc     3120

cccgtggagg gtgagctgct gttccagcct ggggaggcct ggaaagagct gcaggtgaag     3180

ctcctggagc tgcaagaagt tgactccctc ctgcggggcc gccaggtccg ccgtttccac     3240

gtccagctca gcaaccctaa gtttggggcc cacctgggcc agccccactc caccaccatc     3300

atcatcaggg acccagatga actggaccgg agcttcacga gtcagatgtt gtcatcacag     3360

ccaccccctc acggcgacct gggcgccccg cagaacccca atgctaaggc cgctgggtcc     3420

aggaagatcc atttcaactg gctgccccct tctggcaagc caatggggta cagggtaaag     3480

tactggattc agggtgactc cgaatccgaa gcccacctgc tcgacagcaa ggtgccctca     3540

gtggagctca ccaacctgta cccgtattgc gactatgaga tgaaggtgtg cgcctacggg     3600

gctcagggcg agggacccta cagctccctg gtgtcctgcc gcacccacca ggaagtgccc     3660

agcgagccag ggcgtctggc cttcaatgtc gtctcctcca cggtgaccca gctgagctgg     3720

gctgagccgg ctgagaccaa cggtgagatc acagcctacg aggtctgcta tggcctggtc     3780

aacgatgaca accgacctat tgggcccatg aagaaagtgc tggttgacaa ccctaagaac     3840

cggatgctgc ttattgagaa ccttcgggag tcccagccct accgctacac ggtgaaggcg     3900

cgcaacgggg ccggctgggg gcctgagcgg gaggccatca tcaacctggc cacccagccc     3960

aagaggccca tgtccatccc catcatccct gacatcccta tcgtggacgc ccagagcggg     4020

gaggactacg acagcttcct tatgtacagc gatgacgttc tacgctctcc atcgggcagc     4080

cagaggccca gcgtctccga tgacactgag cacctggtga atggccggat ggactttgcc     4140

ttcccgggca gcaccaactc cctgcacagg atgaccacga ccagtgctgc tgcctatggc     4200

acccacctga gcccacacgt gccccaccgc gtgctaagca catcctccac cctcacacgg     4260

gactacaact cactgacccg ctcagaacac tcacactcga ccacactgcc cagggactac     4320

tccaccctca cctccgtctc ctcccacgac tctcgcctga ctgctggtgt gcccgacacg     4380

cccacccgcc tggtgttctc tgccctgggg cccacatctc tcagagtgag ctggcaggag     4440

ccgcggtgcg agcggccgct gcagggctac agtgtggagt accagctgct gaacggcggt     4500

gagctgcatc ggctcaacat ccccaaccct gcccagacct cggtggtggt ggaagacctc     4560

ctgcccaacc actcctacgt gttccgcgtg cgggcccaga gccaggaagg ctggggccga     4620

gagcgtgagg gtgtcatcac cattgaatcc caggtgcacc cgcagagccc actgtgtccc     4680

ctgccaggct ccgccttcac tttgagcact cccagtgccc caggcccgct ggtgttcact     4740

gccctgagcc cagactcgct gcagctgagc tgggagcggc cacggaggcc caatggggat     4800

atcgtcggct acctggtgac ctgtgagatg gcccaaggag gagggccagc caccgcattc     4860

cgggtggatg gagacagccc cgagagccgg ctgaccgtgc cgggcctcag cgagaacgtg     4920

ccctacaagt tcaaggtgca ggccaggacc actgagggct tcgggccaga gcgcgagggc     4980

atcatcacca tagagtccca ggatggagga cccttcccgc agctgggcag ccgtgccggg     5040

ctcttccagc acccgctgca aagcgagtac agcagcatca ccaccaccca caccagcgcc     5100

accgagccct tcctagtgga tgggctgacc ctgggggccc agcacctgga ggcaggcggc     5160

tccctcaccc ggcatgtgac ccaggagttt gtgagccgga cactgaccac cagcggaacc     5220

cttagcaccc acatggacca acagttcttc caaacttga                            5259


<210> 4
<211> 1563
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1563
<223> /db_xref=NCBI:NM_006340/gi222080098:109-1671
      /mol_type="DNA"
      /organism="Homo sapiens"

<400> 4
atgtctctgt ctcgctcaga ggagatgcac cggctcacgg aaaatgtcta taagaccatc      60

atggagcagt tcaaccctag cctccggaac ttcatcgcca tggggaagaa ttacgagaag     120

gcactggcag gtgtgacgta tgcagccaaa ggctactttg acgccctggt gaagatgggg     180

gagctggcca gcgagagcca gggctccaaa gaactcggag acgttctctt ccagatggct     240

gaagtccaca ggcagatcca gaatcagctg gaagaaatgc tgaagtcttt tcacaacgag     300

ctgcttacgc agctggagca gaaggtggag ctggactcca ggtatctgag tgctgcgctg     360

aagaaatacc agactgagca aaggagcaaa ggcgacgccc tggacaagtg tcaggctgag     420

ctgaagaagc ttcggaagaa gagccagggc agcaagaatc ctcagaagta ctcggacaag     480

gagctgcagt acatcgacgc catcagcaac aagcagggcg agctggagaa ttacgtgtcc     540

gacggctaca agaccgcact gacagaggag cgcaggcgct tctgcttcct ggtggagaag     600

cagtgcgccg tggccaagaa ctccgcggcc taccactcca agggcaagga gctgctggcg     660

cagaagctgc cgctgtggca acaggcctgt gccgacccca gcaagatccc ggagcgcgcg     720

gtgcagctca tgcagcaggt ggccagcaac ggcgccaccc tccccagcgc cctgtcggcc     780

tccaagtcca acctggtcat ttccgacccc attccggggg ccaagcccct gccggtgccc     840

cccgagctgg caccgttcgt ggggcggatg tctgcccagg agagcacacc catcatgaac     900

ggcgtcacag gcccggatgg cgaggactac agcccgtggg ctgaccgcaa ggctgcccag     960

cccaaatccc tgtctcctcc gcagtctcag agcaagctca gcgactccta ctccaacaca    1020

ctccccgtgc gcaagagcgt gaccccaaaa aacagctatg ccaccaccga gaacaagact    1080

ctgcctcgct cgagctccat ggcagccggc ctggagcgca atggccgtat gcgggtgaag    1140

gccatcttct cccacgctgc tggggacaac agcaccctcc tgagcttcaa ggagggtgac    1200

ctcattaccc tgctggtgcc tgaggcccgc gatggctggc actacggaga gagtgagaag    1260

accaagatgc ggggctggtt tcccttctcc tacacccggg tcttggacag cgatggcagt    1320

gacaggctgc acatgagcct gcagcaaggg aagagcagca gcacgggcaa cctcctggac    1380

aaggacgacc tggccatccc accccccgat tacggcgccg cctcccgggc cttccccgcc    1440

cagacggcca gcggcttcaa gcagaggccc tacagtgtgg ccgtgcccgc cttctcccag    1500

ggcctggatg actatggagc gcggtccatg agcagcgccg atgtggaagt ggccagattc    1560

tga                                                                  1563


<210> 5
<211> 1822
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1822
<223> /mol_type="protein"
      /note="Uniprot Accession number P16144"
      /organism="Homo sapiens"

<400> 5
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                   15    
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                   25                  30        
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                   40                  45            
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                   55                  60                
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                   70                  75                  80
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                   90                  95    
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                  105                110        
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                  120                125            
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                  135                140                
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                  150                155                  160
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                  170                175    
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                  185                190        
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                  200                205            
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                  215                220                
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                  230                235                  240
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                  250                255    
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                  265                270        
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                  280                285            
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                  295                300                
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                  310                315                  320
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                  330                335    
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                  345                350        
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                  360                365            
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                  375                380                
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                  390                395                  400
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                  410                415    
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                  425                430        
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                  440                445            
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                  455                460                
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                  470                475                  480
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                  490                495    
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                  505                510        
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                  520                525            
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                  535                540                
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                  550                555                  560
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                  570                575    
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                  585                590        
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                  600                605            
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                  615                620                
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                  630                635                  640
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                  650                655    
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                  665                670        
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                  680                685            
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                  695                700                
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                  710                715                  720
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                  730                735    
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                  745                750        
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                  760                765            
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                  775                780                
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                  790                795                  800
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                  810                815    
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                  825                830        
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                  840                845            
Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                  855                860                
Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                  870                875                  880
His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                  890                895    
Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                  905                910        
Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                  920                925            
Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                  935                940                
Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                  950                955                  960
Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                  970                975    
Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                  985                990        
Ser Phe Glu Gln Pro Glu Phe Ser Val Ser Arg Gly Asp Gln Val Ala 
        995                  1000                1005            
Arg Ile Pro Val Ile Arg Arg Val Leu Asp Gly Gly Lys Ser Gln Val 
    1010                1015                1020                
Ser Tyr Arg Thr Gln Asp Gly Thr Ala Gln Gly Asn Arg Asp Tyr Ile 
1025                1030                1035                1040
Pro Val Glu Gly Glu Leu Leu Phe Gln Pro Gly Glu Ala Trp Lys Glu 
                1045                1050                1055    
Leu Gln Val Lys Leu Leu Glu Leu Gln Glu Val Asp Ser Leu Leu Arg 
            1060                1065                1070        
Gly Arg Gln Val Arg Arg Phe His Val Gln Leu Ser Asn Pro Lys Phe 
        1075                1080                1085            
Gly Ala His Leu Gly Gln Pro His Ser Thr Thr Ile Ile Ile Arg Asp 
    1090                1095                1100                
Pro Asp Glu Leu Asp Arg Ser Phe Thr Ser Gln Met Leu Ser Ser Gln 
1105                1110                1115                1120
Pro Pro Pro His Gly Asp Leu Gly Ala Pro Gln Asn Pro Asn Ala Lys 
                1125                1130                1135    
Ala Ala Gly Ser Arg Lys Ile His Phe Asn Trp Leu Pro Pro Ser Gly 
            1140                1145                1150        
Lys Pro Met Gly Tyr Arg Val Lys Tyr Trp Ile Gln Gly Asp Ser Glu 
        1155                1160                1165            
Ser Glu Ala His Leu Leu Asp Ser Lys Val Pro Ser Val Glu Leu Thr 
    1170                1175                1180                
Asn Leu Tyr Pro Tyr Cys Asp Tyr Glu Met Lys Val Cys Ala Tyr Gly 
1185                1190                1195                1200
Ala Gln Gly Glu Gly Pro Tyr Ser Ser Leu Val Ser Cys Arg Thr His 
                1205                1210                1215    
Gln Glu Val Pro Ser Glu Pro Gly Arg Leu Ala Phe Asn Val Val Ser 
            1220                1225                1230        
Ser Thr Val Thr Gln Leu Ser Trp Ala Glu Pro Ala Glu Thr Asn Gly 
        1235                1240                1245            
Glu Ile Thr Ala Tyr Glu Val Cys Tyr Gly Leu Val Asn Asp Asp Asn 
    1250                1255                1260                
Arg Pro Ile Gly Pro Met Lys Lys Val Leu Val Asp Asn Pro Lys Asn 
1265                1270                1275                1280
Arg Met Leu Leu Ile Glu Asn Leu Arg Glu Ser Gln Pro Tyr Arg Tyr 
                1285                1290                1295    
Thr Val Lys Ala Arg Asn Gly Ala Gly Trp Gly Pro Glu Arg Glu Ala 
            1300                1305                1310        
Ile Ile Asn Leu Ala Thr Gln Pro Lys Arg Pro Met Ser Ile Pro Ile 
        1315                1320                1325            
Ile Pro Asp Ile Pro Ile Val Asp Ala Gln Ser Gly Glu Asp Tyr Asp 
    1330                1335                1340                
Ser Phe Leu Met Tyr Ser Asp Asp Val Leu Arg Ser Pro Ser Gly Ser 
1345                1350                1355                1360
Gln Arg Pro Ser Val Ser Asp Asp Thr Gly Cys Gly Trp Lys Phe Glu 
                1365                1370                1375    
Pro Leu Leu Gly Glu Glu Leu Asp Leu Arg Arg Val Thr Trp Arg Leu 
            1380                1385                1390        
Pro Pro Glu Leu Ile Pro Arg Leu Ser Ala Ser Ser Gly Arg Ser Ser 
        1395                1400                1405            
Asp Ala Glu Ala Pro His Gly Pro Pro Asp Asp Gly Gly Ala Gly Gly 
    1410                1415                1420                
Lys Gly Gly Ser Leu Pro Arg Ser Ala Thr Pro Gly Pro Pro Gly Glu 
1425                1430                1435                1440
His Leu Val Asn Gly Arg Met Asp Phe Ala Phe Pro Gly Ser Thr Asn 
                1445                1450                1455    
Ser Leu His Arg Met Thr Thr Thr Ser Ala Ala Ala Tyr Gly Thr His 
            1460                1465                1470        
Leu Ser Pro His Val Pro His Arg Val Leu Ser Thr Ser Ser Thr Leu 
        1475                1480                1485            
Thr Arg Asp Tyr Asn Ser Leu Thr Arg Ser Glu His Ser His Ser Thr 
    1490                1495                1500                
Thr Leu Pro Arg Asp Tyr Ser Thr Leu Thr Ser Val Ser Ser His Asp 
1505                1510                1515                1520
Ser Arg Leu Thr Ala Gly Val Pro Asp Thr Pro Thr Arg Leu Val Phe 
                1525                1530                1535    
Ser Ala Leu Gly Pro Thr Ser Leu Arg Val Ser Trp Gln Glu Pro Arg 
            1540                1545                1550        
Cys Glu Arg Pro Leu Gln Gly Tyr Ser Val Glu Tyr Gln Leu Leu Asn 
        1555                1560                1565            
Gly Gly Glu Leu His Arg Leu Asn Ile Pro Asn Pro Ala Gln Thr Ser 
    1570                1575                1580                
Val Val Val Glu Asp Leu Leu Pro Asn His Ser Tyr Val Phe Arg Val 
1585                1590                1595                1600
Arg Ala Gln Ser Gln Glu Gly Trp Gly Arg Glu Arg Glu Gly Val Ile 
                1605                1610                1615    
Thr Ile Glu Ser Gln Val His Pro Gln Ser Pro Leu Cys Pro Leu Pro 
            1620                1625                1630        
Gly Ser Ala Phe Thr Leu Ser Thr Pro Ser Ala Pro Gly Pro Leu Val 
        1635                1640                1645            
Phe Thr Ala Leu Ser Pro Asp Ser Leu Gln Leu Ser Trp Glu Arg Pro 
    1650                1655                1660                
Arg Arg Pro Asn Gly Asp Ile Val Gly Tyr Leu Val Thr Cys Glu Met 
1665                1670                1675                1680
Ala Gln Gly Gly Gly Pro Ala Thr Ala Phe Arg Val Asp Gly Asp Ser 
                1685                1690                1695    
Pro Glu Ser Arg Leu Thr Val Pro Gly Leu Ser Glu Asn Val Pro Tyr 
            1700                1705                1710        
Lys Phe Lys Val Gln Ala Arg Thr Thr Glu Gly Phe Gly Pro Glu Arg 
        1715                1720                1725            
Glu Gly Ile Ile Thr Ile Glu Ser Gln Asp Gly Gly Pro Phe Pro Gln 
    1730                1735                1740                
Leu Gly Ser Arg Ala Gly Leu Phe Gln His Pro Leu Gln Ser Glu Tyr 
1745                1750                1755                1760
Ser Ser Ile Thr Thr Thr His Thr Ser Ala Thr Glu Pro Phe Leu Val 
                1765                1770                1775    
Asp Gly Leu Thr Leu Gly Ala Gln His Leu Glu Ala Gly Gly Ser Leu 
            1780                1785                1790        
Thr Arg His Val Thr Gln Glu Phe Val Ser Arg Thr Leu Thr Thr Ser 
        1795                1800                1805            
Gly Thr Leu Ser Thr His Met Asp Gln Gln Phe Phe Gln Thr 
    1810                1815                1820        

<210> 6
<211> 1752
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1752
<223> /mol_type="protein"
      /note="Uniprot accession number P16144-2"
      /organism="Homo sapiens"

<400> 6
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                   15    
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                   25                  30        
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                   40                  45            
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                   55                  60                
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                   70                  75                  80
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                   90                  95    
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                  105                110        
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                  120                125            
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                  135                140                
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                  150                155                  160
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                  170                175    
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                  185                190        
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                  200                205            
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                  215                220                
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                  230                235                  240
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                  250                255    
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                  265                270        
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                  280                285            
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                  295                300                
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                  310                315                  320
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                  330                335    
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                  345                350        
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                  360                365            
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                  375                380                
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                  390                395                  400
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                  410                415    
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                  425                430        
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                  440                445            
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                  455                460                
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                  470                475                  480
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                  490                495    
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                  505                510        
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                  520                525            
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                  535                540                
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                  550                555                  560
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                  570                575    
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                  585                590        
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                  600                605            
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                  615                620                
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                  630                635                  640
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                  650                655    
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                  665                670        
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                  680                685            
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                  695                700                
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                  710                715                  720
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                  730                735    
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                  745                750        
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                  760                765            
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                  775                780                
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                  790                795                  800
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                  810                815    
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                  825                830        
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                  840                845            
Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                  855                860                
Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                  870                875                  880
His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                  890                895    
Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                  905                910        
Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                  920                925            
Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                  935                940                
Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                  950                955                  960
Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                  970                975    
Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                  985                990        
Ser Phe Glu Gln Pro Glu Phe Ser Val Ser Arg Gly Asp Gln Val Ala 
        995                  1000                1005            
Arg Ile Pro Val Ile Arg Arg Val Leu Asp Gly Gly Lys Ser Gln Val 
    1010                1015                1020                
Ser Tyr Arg Thr Gln Asp Gly Thr Ala Gln Gly Asn Arg Asp Tyr Ile 
1025                1030                1035                1040
Pro Val Glu Gly Glu Leu Leu Phe Gln Pro Gly Glu Ala Trp Lys Glu 
                1045                1050                1055    
Leu Gln Val Lys Leu Leu Glu Leu Gln Glu Val Asp Ser Leu Leu Arg 
            1060                1065                1070        
Gly Arg Gln Val Arg Arg Phe His Val Gln Leu Ser Asn Pro Lys Phe 
        1075                1080                1085            
Gly Ala His Leu Gly Gln Pro His Ser Thr Thr Ile Ile Ile Arg Asp 
    1090                1095                1100                
Pro Asp Glu Leu Asp Arg Ser Phe Thr Ser Gln Met Leu Ser Ser Gln 
1105                1110                1115                1120
Pro Pro Pro His Gly Asp Leu Gly Ala Pro Gln Asn Pro Asn Ala Lys 
                1125                1130                1135    
Ala Ala Gly Ser Arg Lys Ile His Phe Asn Trp Leu Pro Pro Ser Gly 
            1140                1145                1150        
Lys Pro Met Gly Tyr Arg Val Lys Tyr Trp Ile Gln Gly Asp Ser Glu 
        1155                1160                1165            
Ser Glu Ala His Leu Leu Asp Ser Lys Val Pro Ser Val Glu Leu Thr 
    1170                1175                1180                
Asn Leu Tyr Pro Tyr Cys Asp Tyr Glu Met Lys Val Cys Ala Tyr Gly 
1185                1190                1195                1200
Ala Gln Gly Glu Gly Pro Tyr Ser Ser Leu Val Ser Cys Arg Thr His 
                1205                1210                1215    
Gln Glu Val Pro Ser Glu Pro Gly Arg Leu Ala Phe Asn Val Val Ser 
            1220                1225                1230        
Ser Thr Val Thr Gln Leu Ser Trp Ala Glu Pro Ala Glu Thr Asn Gly 
        1235                1240                1245            
Glu Ile Thr Ala Tyr Glu Val Cys Tyr Gly Leu Val Asn Asp Asp Asn 
    1250                1255                1260                
Arg Pro Ile Gly Pro Met Lys Lys Val Leu Val Asp Asn Pro Lys Asn 
1265                1270                1275                1280
Arg Met Leu Leu Ile Glu Asn Leu Arg Glu Ser Gln Pro Tyr Arg Tyr 
                1285                1290                1295    
Thr Val Lys Ala Arg Asn Gly Ala Gly Trp Gly Pro Glu Arg Glu Ala 
            1300                1305                1310        
Ile Ile Asn Leu Ala Thr Gln Pro Lys Arg Pro Met Ser Ile Pro Ile 
        1315                1320                1325            
Ile Pro Asp Ile Pro Ile Val Asp Ala Gln Ser Gly Glu Asp Tyr Asp 
    1330                1335                1340                
Ser Phe Leu Met Tyr Ser Asp Asp Val Leu Arg Ser Pro Ser Gly Ser 
1345                1350                1355                1360
Gln Arg Pro Ser Val Ser Asp Asp Thr Glu His Leu Val Asn Gly Arg 
                1365                1370                1375    
Met Asp Phe Ala Phe Pro Gly Ser Thr Asn Ser Leu His Arg Met Thr 
            1380                1385                1390        
Thr Thr Ser Ala Ala Ala Tyr Gly Thr His Leu Ser Pro His Val Pro 
        1395                1400                1405            
His Arg Val Leu Ser Thr Ser Ser Thr Leu Thr Arg Asp Tyr Asn Ser 
    1410                1415                1420                
Leu Thr Arg Ser Glu His Ser His Ser Thr Thr Leu Pro Arg Asp Tyr 
1425                1430                1435                1440
Ser Thr Leu Thr Ser Val Ser Ser His Asp Ser Arg Leu Thr Ala Gly 
                1445                1450                1455    
Val Pro Asp Thr Pro Thr Arg Leu Val Phe Ser Ala Leu Gly Pro Thr 
            1460                1465                1470        
Ser Leu Arg Val Ser Trp Gln Glu Pro Arg Cys Glu Arg Pro Leu Gln 
        1475                1480                1485            
Gly Tyr Ser Val Glu Tyr Gln Leu Leu Asn Gly Gly Glu Leu His Arg 
    1490                1495                1500                
Leu Asn Ile Pro Asn Pro Ala Gln Thr Ser Val Val Val Glu Asp Leu 
1505                1510                1515                1520
Leu Pro Asn His Ser Tyr Val Phe Arg Val Arg Ala Gln Ser Gln Glu 
                1525                1530                1535    
Gly Trp Gly Arg Glu Arg Glu Gly Val Ile Thr Ile Glu Ser Gln Val 
            1540                1545                1550        
His Pro Gln Ser Pro Leu Cys Pro Leu Pro Gly Ser Ala Phe Thr Leu 
        1555                1560                1565            
Ser Thr Pro Ser Ala Pro Gly Pro Leu Val Phe Thr Ala Leu Ser Pro 
    1570                1575                1580                
Asp Ser Leu Gln Leu Ser Trp Glu Arg Pro Arg Arg Pro Asn Gly Asp 
1585                1590                1595                1600
Ile Val Gly Tyr Leu Val Thr Cys Glu Met Ala Gln Gly Gly Gly Pro 
                1605                1610                1615    
Ala Thr Ala Phe Arg Val Asp Gly Asp Ser Pro Glu Ser Arg Leu Thr 
            1620                1625                1630        
Val Pro Gly Leu Ser Glu Asn Val Pro Tyr Lys Phe Lys Val Gln Ala 
        1635                1640                1645            
Arg Thr Thr Glu Gly Phe Gly Pro Glu Arg Glu Gly Ile Ile Thr Ile 
    1650                1655                1660                
Glu Ser Gln Asp Gly Gly Pro Phe Pro Gln Leu Gly Ser Arg Ala Gly 
1665                1670                1675                1680
Leu Phe Gln His Pro Leu Gln Ser Glu Tyr Ser Ser Ile Thr Thr Thr 
                1685                1690                1695    
His Thr Ser Ala Thr Glu Pro Phe Leu Val Asp Gly Leu Thr Leu Gly 
            1700                1705                1710        
Ala Gln His Leu Glu Ala Gly Gly Ser Leu Thr Arg His Val Thr Gln 
        1715                1720                1725            
Glu Phe Val Ser Arg Thr Leu Thr Thr Ser Gly Thr Leu Ser Thr His 
    1730                1735                1740                
Met Asp Gln Gln Phe Phe Gln Thr 
1745                1750        

<210> 7
<211> 1805
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1805
<223> /mol_type="protein"
      /note="Uniprot accession number P16144-3"
      /organism="Homo sapiens"

<400> 7
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                   15    
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                   25                  30        
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                   40                  45            
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                   55                  60                
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                   70                  75                  80
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                   90                  95    
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                  105                110        
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                  120                125            
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                  135                140                
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                  150                155                  160
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                  170                175    
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                  185                190        
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                  200                205            
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                  215                220                
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                  230                235                  240
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                  250                255    
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                  265                270        
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                  280                285            
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                  295                300                
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                  310                315                  320
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                  330                335    
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                  345                350        
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                  360                365            
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                  375                380                
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                  390                395                  400
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                  410                415    
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                  425                430        
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                  440                445            
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                  455                460                
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                  470                475                  480
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                  490                495    
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                  505                510        
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                  520                525            
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                  535                540                
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                  550                555                  560
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                  570                575    
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                  585                590        
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                  600                605            
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                  615                620                
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                  630                635                  640
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                  650                655    
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                  665                670        
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                  680                685            
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                  695                700                
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                  710                715                  720
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                  730                735    
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                  745                750        
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                  760                765            
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                  775                780                
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                  790                795                  800
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                  810                815    
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                  825                830        
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                  840                845            
Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                  855                860                
Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                  870                875                  880
His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                  890                895    
Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                  905                910        
Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                  920                925            
Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                  935                940                
Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                  950                955                  960
Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                  970                975    
Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                  985                990        
Ser Phe Glu Gln Pro Glu Phe Ser Val Ser Arg Gly Asp Gln Val Ala 
        995                  1000                1005            
Arg Ile Pro Val Ile Arg Arg Val Leu Asp Gly Gly Lys Ser Gln Val 
    1010                1015                1020                
Ser Tyr Arg Thr Gln Asp Gly Thr Ala Gln Gly Asn Arg Asp Tyr Ile 
1025                1030                1035                1040
Pro Val Glu Gly Glu Leu Leu Phe Gln Pro Gly Glu Ala Trp Lys Glu 
                1045                1050                1055    
Leu Gln Val Lys Leu Leu Glu Leu Gln Glu Val Asp Ser Leu Leu Arg 
            1060                1065                1070        
Gly Arg Gln Val Arg Arg Phe His Val Gln Leu Ser Asn Pro Lys Phe 
        1075                1080                1085            
Gly Ala His Leu Gly Gln Pro His Ser Thr Thr Ile Ile Ile Arg Asp 
    1090                1095                1100                
Pro Asp Glu Leu Asp Arg Ser Phe Thr Ser Gln Met Leu Ser Ser Gln 
1105                1110                1115                1120
Pro Pro Pro His Gly Asp Leu Gly Ala Pro Gln Asn Pro Asn Ala Lys 
                1125                1130                1135    
Ala Ala Gly Ser Arg Lys Ile His Phe Asn Trp Leu Pro Pro Ser Gly 
            1140                1145                1150        
Lys Pro Met Gly Tyr Arg Val Lys Tyr Trp Ile Gln Gly Asp Ser Glu 
        1155                1160                1165            
Ser Glu Ala His Leu Leu Asp Ser Lys Val Pro Ser Val Glu Leu Thr 
    1170                1175                1180                
Asn Leu Tyr Pro Tyr Cys Asp Tyr Glu Met Lys Val Cys Ala Tyr Gly 
1185                1190                1195                1200
Ala Gln Gly Glu Gly Pro Tyr Ser Ser Leu Val Ser Cys Arg Thr His 
                1205                1210                1215    
Gln Glu Val Pro Ser Glu Pro Gly Arg Leu Ala Phe Asn Val Val Ser 
            1220                1225                1230        
Ser Thr Val Thr Gln Leu Ser Trp Ala Glu Pro Ala Glu Thr Asn Gly 
        1235                1240                1245            
Glu Ile Thr Ala Tyr Glu Val Cys Tyr Gly Leu Val Asn Asp Asp Asn 
    1250                1255                1260                
Arg Pro Ile Gly Pro Met Lys Lys Val Leu Val Asp Asn Pro Lys Asn 
1265                1270                1275                1280
Arg Met Leu Leu Ile Glu Asn Leu Arg Glu Ser Gln Pro Tyr Arg Tyr 
                1285                1290                1295    
Thr Val Lys Ala Arg Asn Gly Ala Gly Trp Gly Pro Glu Arg Glu Ala 
            1300                1305                1310        
Ile Ile Asn Leu Ala Thr Gln Pro Lys Arg Pro Met Ser Ile Pro Ile 
        1315                1320                1325            
Ile Pro Asp Ile Pro Ile Val Asp Ala Gln Ser Gly Glu Asp Tyr Asp 
    1330                1335                1340                
Ser Phe Leu Met Tyr Ser Asp Asp Val Leu Arg Ser Pro Ser Gly Ser 
1345                1350                1355                1360
Gln Arg Pro Ser Val Ser Asp Asp Thr Glu His Leu Val Asn Gly Arg 
                1365                1370                1375    
Met Asp Phe Ala Phe Pro Gly Ser Thr Asn Ser Leu His Arg Met Thr 
            1380                1385                1390        
Thr Thr Ser Ala Ala Ala Tyr Gly Thr His Leu Ser Pro His Val Pro 
        1395                1400                1405            
His Arg Val Leu Ser Thr Ser Ser Thr Leu Thr Arg Asp Tyr Asn Ser 
    1410                1415                1420                
Leu Thr Arg Ser Glu His Ser His Ser Thr Thr Leu Pro Arg Asp Tyr 
1425                1430                1435                1440
Ser Thr Leu Thr Ser Val Ser Ser His Gly Leu Pro Pro Ile Trp Glu 
                1445                1450                1455    
His Gly Arg Ser Arg Leu Pro Leu Ser Trp Ala Leu Gly Ser Arg Ser 
            1460                1465                1470        
Arg Ala Gln Met Lys Gly Phe Pro Pro Ser Arg Gly Pro Arg Asp Ser 
        1475                1480                1485            
Ile Ile Leu Ala Gly Arg Pro Ala Ala Pro Ser Trp Gly Pro Asp Ser 
    1490                1495                1500                
Arg Leu Thr Ala Gly Val Pro Asp Thr Pro Thr Arg Leu Val Phe Ser 
1505                1510                1515                1520
Ala Leu Gly Pro Thr Ser Leu Arg Val Ser Trp Gln Glu Pro Arg Cys 
                1525                1530                1535    
Glu Arg Pro Leu Gln Gly Tyr Ser Val Glu Tyr Gln Leu Leu Asn Gly 
            1540                1545                1550        
Gly Glu Leu His Arg Leu Asn Ile Pro Asn Pro Ala Gln Thr Ser Val 
        1555                1560                1565            
Val Val Glu Asp Leu Leu Pro Asn His Ser Tyr Val Phe Arg Val Arg 
    1570                1575                1580                
Ala Gln Ser Gln Glu Gly Trp Gly Arg Glu Arg Glu Gly Val Ile Thr 
1585                1590                1595                1600
Ile Glu Ser Gln Val His Pro Gln Ser Pro Leu Cys Pro Leu Pro Gly 
                1605                1610                1615    
Ser Ala Phe Thr Leu Ser Thr Pro Ser Ala Pro Gly Pro Leu Val Phe 
            1620                1625                1630        
Thr Ala Leu Ser Pro Asp Ser Leu Gln Leu Ser Trp Glu Arg Pro Arg 
        1635                1640                1645            
Arg Pro Asn Gly Asp Ile Val Gly Tyr Leu Val Thr Cys Glu Met Ala 
    1650                1655                1660                
Gln Gly Gly Gly Pro Ala Thr Ala Phe Arg Val Asp Gly Asp Ser Pro 
1665                1670                1675                1680
Glu Ser Arg Leu Thr Val Pro Gly Leu Ser Glu Asn Val Pro Tyr Lys 
                1685                1690                1695    
Phe Lys Val Gln Ala Arg Thr Thr Glu Gly Phe Gly Pro Glu Arg Glu 
            1700                1705                1710        
Gly Ile Ile Thr Ile Glu Ser Gln Asp Gly Gly Pro Phe Pro Gln Leu 
        1715                1720                1725            
Gly Ser Arg Ala Gly Leu Phe Gln His Pro Leu Gln Ser Glu Tyr Ser 
    1730                1735                1740                
Ser Ile Thr Thr Thr His Thr Ser Ala Thr Glu Pro Phe Leu Val Asp 
1745                1750                1755                1760
Gly Leu Thr Leu Gly Ala Gln His Leu Glu Ala Gly Gly Ser Leu Thr 
                1765                1770                1775    
Arg His Val Thr Gln Glu Phe Val Ser Arg Thr Leu Thr Thr Ser Gly 
            1780                1785                1790        
Thr Leu Ser Thr His Met Asp Gln Gln Phe Phe Gln Thr 
        1795                1800                1805

<210> 8
<211> 1745
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1745
<223> /mol_type="protein"
      /note="Uniprot accession number P16144-4"
      /organism="Homo sapiens"

<400> 8
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                   15    
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                   25                  30        
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                   40                  45            
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                   55                  60                
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                   70                  75                  80
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                   90                  95    
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                  105                110        
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                  120                125            
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                  135                140                
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                  150                155                  160
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                  170                175    
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                  185                190        
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                  200                205            
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                  215                220                
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                  230                235                  240
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                  250                255    
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                  265                270        
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                  280                285            
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                  295                300                
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                  310                315                  320
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                  330                335    
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                  345                350        
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                  360                365            
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                  375                380                
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                  390                395                  400
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                  410                415    
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                  425                430        
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                  440                445            
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                  455                460                
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                  470                475                  480
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                  490                495    
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                  505                510        
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                  520                525            
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                  535                540                
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                  550                555                  560
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                  570                575    
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                  585                590        
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                  600                605            
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                  615                620                
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                  630                635                  640
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                  650                655    
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                  665                670        
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                  680                685            
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                  695                700                
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                  710                715                  720
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                  730                735    
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                  745                750        
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                  760                765            
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                  775                780                
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                  790                795                  800
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                  810                815    
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                  825                830        
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                  840                845            
Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                  855                860                
Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                  870                875                  880
His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                  890                895    
Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                  905                910        
Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                  920                925            
Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                  935                940                
Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                  950                955                  960
Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                  970                975    
Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                  985                990        
Ser Phe Glu Gln Pro Glu Phe Ser Val Ser Arg Gly Asp Gln Val Ala 
        995                  1000                1005            
Arg Ile Pro Val Ile Arg Arg Val Leu Asp Gly Gly Lys Ser Gln Val 
    1010                1015                1020                
Ser Tyr Arg Thr Gln Asp Gly Thr Ala Gln Gly Asn Arg Asp Tyr Ile 
1025                1030                1035                1040
Pro Val Glu Gly Glu Leu Leu Phe Gln Pro Gly Glu Ala Trp Lys Glu 
                1045                1050                1055    
Leu Gln Val Lys Leu Leu Glu Leu Gln Glu Val Asp Ser Leu Leu Arg 
            1060                1065                1070        
Gly Arg Gln Val Arg Arg Phe His Val Gln Leu Ser Asn Pro Lys Phe 
        1075                1080                1085            
Gly Ala His Leu Gly Gln Pro His Ser Thr Thr Ile Ile Ile Arg Asp 
    1090                1095                1100                
Pro Asp Glu Leu Asp Arg Ser Phe Thr Ser Gln Met Leu Ser Ser Gln 
1105                1110                1115                1120
Pro Pro Pro His Gly Asp Leu Gly Ala Pro Gln Asn Pro Asn Ala Lys 
                1125                1130                1135    
Ala Ala Gly Ser Arg Lys Ile His Phe Asn Trp Leu Pro Pro Ser Gly 
            1140                1145                1150        
Lys Pro Met Gly Tyr Arg Val Lys Tyr Trp Ile Gln Gly Asp Ser Glu 
        1155                1160                1165            
Ser Glu Ala His Leu Leu Asp Ser Lys Val Pro Ser Val Glu Leu Thr 
    1170                1175                1180                
Asn Leu Tyr Pro Tyr Cys Asp Tyr Glu Met Lys Val Cys Ala Tyr Gly 
1185                1190                1195                1200
Ala Gln Gly Glu Gly Pro Tyr Ser Ser Leu Val Ser Cys Arg Thr His 
                1205                1210                1215    
Gln Glu Val Pro Ser Glu Pro Gly Arg Leu Ala Phe Asn Val Val Ser 
            1220                1225                1230        
Ser Thr Val Thr Gln Leu Ser Trp Ala Glu Pro Ala Glu Thr Asn Gly 
        1235                1240                1245            
Glu Ile Thr Ala Tyr Glu Val Cys Tyr Gly Leu Val Asn Asp Asp Asn 
    1250                1255                1260                
Arg Pro Ile Gly Pro Met Lys Lys Val Leu Val Asp Asn Pro Lys Asn 
1265                1270                1275                1280
Arg Met Leu Leu Ile Glu Asn Leu Arg Glu Ser Gln Pro Tyr Arg Tyr 
                1285                1290                1295    
Thr Val Lys Ala Arg Asn Gly Ala Gly Trp Gly Pro Glu Arg Glu Ala 
            1300                1305                1310        
Ile Ile Asn Leu Ala Thr Gln Pro Lys Arg Pro Met Ser Ile Pro Ile 
        1315                1320                1325            
Ile Pro Asp Ile Pro Ile Val Asp Ala Gln Ser Gly Glu Asp Tyr Asp 
    1330                1335                1340                
Ser Phe Leu Met Tyr Ser Asp Asp Val Leu Arg Ser Pro Ser Gly Ser 
1345                1350                1355                1360
Gln Arg Pro Ser Val Ser Asp Asp Thr Glu His Leu Val Asn Gly Arg 
                1365                1370                1375    
Met Asp Phe Ala Phe Pro Gly Ser Thr Asn Ser Leu His Arg Met Thr 
            1380                1385                1390        
Thr Thr Ser Ala Ala Ala Tyr Gly Thr His Leu Ser Pro His Val Pro 
        1395                1400                1405            
His Arg Val Leu Ser Thr Ser Ser Thr Leu Thr Arg Asp Tyr Asn Ser 
    1410                1415                1420                
Leu Thr Arg Ser Glu His Ser His Ser Thr Thr Leu Pro Arg Asp Tyr 
1425                1430                1435                1440
Ser Thr Leu Thr Ser Val Ser Ser His Asp Ser Arg Leu Thr Ala Gly 
                1445                1450                1455    
Val Pro Asp Thr Pro Thr Arg Leu Val Phe Ser Ala Leu Gly Pro Thr 
            1460                1465                1470        
Ser Leu Arg Val Ser Trp Gln Glu Pro Arg Cys Glu Arg Pro Leu Gln 
        1475                1480                1485            
Gly Tyr Ser Val Glu Tyr Gln Leu Leu Asn Gly Gly Glu Leu His Arg 
    1490                1495                1500                
Leu Asn Ile Pro Asn Pro Ala Gln Thr Ser Val Val Val Glu Asp Leu 
1505                1510                1515                1520
Leu Pro Asn His Ser Tyr Val Phe Arg Val Arg Ala Gln Ser Gln Glu 
                1525                1530                1535    
Gly Trp Gly Arg Glu Arg Glu Gly Val Ile Thr Ile Glu Ser Gln Val 
            1540                1545                1550        
His Pro Gln Ser Pro Leu Cys Pro Leu Pro Gly Ser Ala Phe Thr Leu 
        1555                1560                1565            
Ser Thr Pro Ser Ala Pro Gly Pro Leu Val Phe Thr Ala Leu Ser Pro 
    1570                1575                1580                
Asp Ser Leu Gln Leu Ser Trp Glu Arg Pro Arg Arg Pro Asn Gly Asp 
1585                1590                1595                1600
Ile Val Gly Tyr Leu Val Thr Trp Pro Ala Thr Ala Phe Arg Val Asp 
                1605                1610                1615    
Gly Asp Ser Pro Glu Ser Arg Leu Thr Val Pro Gly Leu Ser Glu Asn 
            1620                1625                1630        
Val Pro Tyr Lys Phe Lys Val Gln Ala Arg Thr Thr Glu Gly Phe Gly 
        1635                1640                1645            
Pro Glu Arg Glu Gly Ile Ile Thr Ile Glu Ser Gln Asp Gly Gly Pro 
    1650                1655                1660                
Phe Pro Gln Leu Gly Ser Arg Ala Gly Leu Phe Gln His Pro Leu Gln 
1665                1670                1675                1680
Ser Glu Tyr Ser Ser Ile Thr Thr Thr His Thr Ser Ala Thr Glu Pro 
                1685                1690                1695    
Phe Leu Val Asp Gly Leu Thr Leu Gly Ala Gln His Leu Glu Ala Gly 
            1700                1705                1710        
Gly Ser Leu Thr Arg His Val Thr Gln Glu Phe Val Ser Arg Thr Leu 
        1715                1720                1725            
Thr Thr Ser Gly Thr Leu Ser Thr His Met Asp Gln Gln Phe Phe Gln 
    1730                1735                1740                
Thr 
1745

<210> 9
<211> 520
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..520
<223> /mol_type="protein"
      /note="Uniprot accession number Q9UQB8-5"
      /organism="Homo sapiens"

<400> 9
Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Thr Glu Asn Val 
1               5                   10                   15    
Tyr Lys Thr Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile 
            20                   25                  30        
Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Thr Tyr Ala 
        35                   40                  45            
Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser 
    50                   55                  60                
Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala 
65                   70                  75                  80
Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys Ser 
                85                   90                  95    
Phe His Asn Glu Leu Leu Thr Gln Leu Glu Gln Lys Val Glu Leu Asp 
            100                  105                110        
Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys Tyr Gln Thr Glu Gln Arg 
        115                  120                125            
Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys Leu 
    130                  135                140                
Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp Lys 
145                  150                155                  160
Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn Lys Gln Gly Glu Leu Glu 
                165                  170                175    
Asn Tyr Val Ser Asp Gly Tyr Lys Thr Ala Leu Thr Glu Glu Arg Arg 
            180                  185                190        
Arg Phe Cys Phe Leu Val Glu Lys Gln Cys Ala Val Ala Lys Asn Ser 
        195                  200                205            
Ala Ala Tyr His Ser Lys Gly Lys Glu Leu Leu Ala Gln Lys Leu Pro 
    210                  215                220                
Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser Lys Ile Pro Glu Arg Ala 
225                  230                235                  240
Val Gln Leu Met Gln Gln Val Ala Ser Asn Gly Ala Thr Leu Pro Ser 
                245                  250                255    
Ala Leu Ser Ala Ser Lys Ser Asn Leu Val Ile Ser Asp Pro Ile Pro 
            260                  265                270        
Gly Ala Lys Pro Leu Pro Val Pro Pro Glu Leu Ala Pro Phe Val Gly 
        275                  280                285            
Arg Met Ser Ala Gln Glu Ser Thr Pro Ile Met Asn Gly Val Thr Gly 
    290                  295                300                
Pro Asp Gly Glu Asp Tyr Ser Pro Trp Ala Asp Arg Lys Ala Ala Gln 
305                  310                315                  320
Pro Lys Ser Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp Ser 
                325                  330                335    
Tyr Ser Asn Thr Leu Pro Val Arg Lys Ser Val Thr Pro Lys Asn Ser 
            340                  345                350        
Tyr Ala Thr Thr Glu Asn Lys Thr Leu Pro Arg Ser Ser Ser Met Ala 
        355                  360                365            
Ala Gly Leu Glu Arg Asn Gly Arg Met Arg Val Lys Ala Ile Phe Ser 
    370                  375                380                
His Ala Ala Gly Asp Asn Ser Thr Leu Leu Ser Phe Lys Glu Gly Asp 
385                  390                395                  400
Leu Ile Thr Leu Leu Val Pro Glu Ala Arg Asp Gly Trp His Tyr Gly 
                405                  410                415    
Glu Ser Glu Lys Thr Lys Met Arg Gly Trp Phe Pro Phe Ser Tyr Thr 
            420                  425                430        
Arg Val Leu Asp Ser Asp Gly Ser Asp Arg Leu His Met Ser Leu Gln 
        435                  440                445            
Gln Gly Lys Ser Ser Ser Thr Gly Asn Leu Leu Asp Lys Asp Asp Leu 
    450                  455                460                
Ala Ile Pro Pro Pro Asp Tyr Gly Ala Ala Ser Arg Ala Phe Pro Ala 
465                  470                475                  480
Gln Thr Ala Ser Gly Phe Lys Gln Arg Pro Tyr Ser Val Ala Val Pro 
                485                  490                495    
Ala Phe Ser Gln Gly Leu Asp Asp Tyr Gly Ala Arg Ser Met Ser Ser 
            500                  505                510        
Ala Asp Val Glu Val Ala Arg Phe 
        515                  520

<210> 10
<211> 357
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..357
<223> /mol_type="protein"
      /note="Uniprot accession number Q8NFJ5"
      /organism="Homo sapiens"

<400> 10
Met Ala Thr Thr Val Pro Asp Gly Cys Arg Asn Gly Leu Lys Ser Lys 
1               5                   10                   15    
Tyr Tyr Arg Leu Cys Asp Lys Ala Glu Ala Trp Gly Ile Val Leu Glu 
            20                   25                  30        
Thr Val Ala Thr Ala Gly Val Val Thr Ser Val Ala Phe Met Leu Thr 
        35                   40                  45            
Leu Pro Ile Leu Val Cys Lys Val Gln Asp Ser Asn Arg Arg Lys Met 
    50                   55                  60                
Leu Pro Thr Gln Phe Leu Phe Leu Leu Gly Val Leu Gly Ile Phe Gly 
65                   70                  75                  80
Leu Thr Phe Ala Phe Ile Ile Gly Leu Asp Gly Ser Thr Gly Pro Thr 
                85                   90                  95    
Arg Phe Phe Leu Phe Gly Ile Leu Phe Ser Ile Cys Phe Ser Cys Leu 
            100                  105                110        
Leu Ala His Ala Val Ser Leu Thr Lys Leu Val Arg Gly Arg Lys Pro 
        115                  120                125            
Leu Ser Leu Leu Val Ile Leu Gly Leu Ala Val Gly Phe Ser Leu Val 
    130                  135                140                
Gln Asp Val Ile Ala Ile Glu Tyr Ile Val Leu Thr Met Asn Arg Thr 
145                  150                155                  160
Asn Val Asn Val Phe Ser Glu Leu Ser Ala Pro Arg Arg Asn Glu Asp 
                165                  170                175    
Phe Val Leu Leu Leu Thr Tyr Val Leu Phe Leu Met Ala Leu Thr Phe 
            180                  185                190        
Leu Met Ser Ser Phe Thr Phe Cys Gly Ser Phe Thr Gly Trp Lys Arg 
        195                  200                205            
His Gly Ala His Ile Tyr Leu Thr Met Leu Leu Ser Ile Ala Ile Trp 
    210                  215                220                
Val Ala Trp Ile Thr Leu Leu Met Leu Pro Asp Phe Asp Arg Arg Trp 
225                  230                235                  240
Asp Asp Thr Ile Leu Ser Ser Ala Leu Ala Ala Asn Gly Trp Val Phe 
                245                  250                255    
Leu Leu Ala Tyr Val Ser Pro Glu Phe Trp Leu Leu Thr Lys Gln Arg 
            260                  265                270        
Asn Pro Met Asp Tyr Pro Val Glu Asp Ala Phe Cys Lys Pro Gln Leu 
        275                  280                285            
Val Lys Lys Ser Tyr Gly Val Glu Asn Arg Ala Tyr Ser Gln Glu Glu 
    290                  295                300                
Ile Thr Gln Gly Phe Glu Glu Thr Gly Asp Thr Leu Tyr Ala Pro Tyr 
305                  310                315                  320
Ser Thr His Phe Gln Leu Gln Asn Gln Pro Pro Gln Lys Glu Phe Ser 
                325                  330                335    
Ile Pro Arg Ala His Ala Trp Pro Ser Pro Tyr Lys Asp Tyr Glu Val 
            340                  345                350        
Lys Lys Glu Gly Ser 
        355        

<210> 11
<211> 2671
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..2671
<223> /mol_type="protein"
      /note="Uniprot accession number Q14573"
      /organism="Homo sapiens"

<400> 11
Met Ser Glu Met Ser Ser Phe Leu His Ile Gly Asp Ile Val Ser Leu 
1               5                   10                   15    
Tyr Ala Glu Gly Ser Val Asn Gly Phe Ile Ser Thr Leu Gly Leu Val 
            20                   25                  30        
Asp Asp Arg Cys Val Val Glu Pro Ala Ala Gly Asp Leu Asp Asn Pro 
        35                   40                  45            
Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Val Cys Pro Met Asn Arg 
    50                   55                  60                
Tyr Ser Ala Gln Lys Gln Tyr Trp Lys Ala Lys Gln Thr Lys Gln Asp 
65                   70                  75                  80
Lys Glu Lys Ile Ala Asp Val Val Leu Leu Gln Lys Leu Gln His Ala 
                85                   90                  95    
Ala Gln Met Glu Gln Lys Gln Asn Asp Thr Glu Asn Lys Lys Val His 
            100                  105                110        
Gly Asp Val Val Lys Tyr Gly Ser Val Ile Gln Leu Leu His Met Lys 
        115                  120                125            
Ser Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu 
    130                  135                140                
Lys Asn Ala Met Arg Val Thr Leu Asp Ala Thr Gly Asn Glu Gly Ser 
145                  150                155                  160
Trp Leu Phe Ile Gln Pro Phe Trp Lys Leu Arg Ser Asn Gly Asp Asn 
                165                  170                175    
Val Val Val Gly Asp Lys Val Ile Leu Asn Pro Val Asn Ala Gly Gln 
            180                  185                190        
Pro Leu His Ala Ser Asn Tyr Glu Leu Ser Asp Asn Ala Gly Cys Lys 
        195                  200                205            
Glu Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Asn Leu Phe 
    210                  215                220                
Met Gln Phe Arg Asp His Leu Glu Glu Val Leu Lys Gly Gly Asp Val 
225                  230                235                  240
Val Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu 
                245                  250                255    
Tyr Lys Gly Lys Leu Gln Val Phe Leu Arg Thr Thr Leu Arg Gln Ser 
            260                  265                270        
Ala Thr Ser Ala Thr Ser Ser Asn Ala Leu Trp Glu Val Glu Val Val 
        275                  280                285            
His His Asp Pro Cys Arg Gly Gly Ala Gly His Trp Asn Gly Leu Tyr 
    290                  295                300                
Arg Phe Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Glu Asn 
305                  310                315                  320
Pro Ser Tyr Lys Gly Asp Ala Ser Asp Pro Lys Ala Ala Gly Met Gly 
                325                  330                335    
Ala Gln Gly Arg Thr Gly Arg Arg Asn Ala Gly Glu Lys Ile Lys Tyr 
            340                  345                350        
Cys Leu Val Ala Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu 
        355                  360                365            
Leu Asp Pro Thr Thr Leu Gln Lys Thr Asp Ser Phe Val Pro Arg Asn 
    370                  375                380                
Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Ile Gln Ser 
385                  390                395                  400
Thr Asn Val Pro Ile Asp Ile Glu Glu Glu Arg Pro Ile Arg Leu Met 
                405                  410                415    
Leu Gly Thr Cys Pro Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val 
            420                  425                430        
Ser Val Pro Val Ser Glu Ile Arg Asp Leu Asp Phe Ala Asn Asp Ala 
        435                  440                445            
Ser Ser Met Leu Ala Ser Ala Val Glu Lys Leu Asn Glu Gly Phe Ile 
    450                  455                460                
Ser Gln Asn Asp Arg Arg Phe Val Ile Gln Leu Leu Glu Asp Leu Val 
465                  470                475                  480
Phe Phe Val Ser Asp Val Pro Asn Asn Gly Gln Asn Val Leu Asp Ile 
                485                  490                495    
Met Val Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln 
            500                  505                510        
Asn Ile Leu Lys Gln Val Phe Gly Ile Leu Lys Ala Pro Phe Arg Glu 
        515                  520                525            
Lys Gly Gly Glu Gly Pro Leu Val Arg Leu Glu Glu Leu Ser Asp Gln 
    530                  535                540                
Lys Asn Ala Pro Tyr Gln His Met Phe Arg Leu Cys Tyr Arg Val Leu 
545                  550                555                  560
Arg His Ser Gln Glu Asp Tyr Arg Lys Asn Gln Glu His Ile Ala Lys 
                565                  570                575    
Gln Phe Gly Met Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu 
            580                  585                590        
Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                  600                605            
His Ile Thr Lys Thr Glu Val Glu Thr Phe Val Ser Leu Val Arg Lys 
    610                  615                620                
Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                  630                635                  640
Asn His Ile Ala Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Cys Val 
                645                  650                655    
Leu Asp Pro Lys Asn Ser Asp Ile Leu Ile Arg Thr Glu Leu Arg Pro 
            660                  665                670        
Val Lys Glu Met Ala Gln Ser His Glu Tyr Leu Ser Ile Glu Tyr Ser 
        675                  680                685            
Glu Glu Glu Val Trp Leu Thr Trp Thr Asp Lys Asn Asn Glu His His 
    690                  695                700                
Glu Lys Ser Val Arg Gln Leu Ala Gln Glu Ala Arg Ala Gly Asn Ala 
705                  710                715                  720
His Asp Glu Asn Val Leu Ser Tyr Tyr Arg Tyr Gln Leu Lys Leu Phe 
                725                  730                735    
Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile Asp Glu Ile Ser 
            740                  745                750        
Gln Gln Leu Gly Val Asp Leu Ile Phe Leu Cys Met Ala Asp Glu Met 
        755                  760                765            
Leu Pro Phe Asp Leu Arg Ala Ser Phe Cys His Leu Met Leu His Val 
    770                  775                780                
His Val Asp Arg Asp Pro Gln Glu Leu Val Thr Pro Val Lys Phe Ala 
785                  790                795                  800
Arg Leu Trp Thr Glu Ile Pro Thr Ala Ile Thr Ile Lys Asp Tyr Asp 
                805                  810                815    
Ser Asn Leu Asn Ala Ser Arg Asp Asp Lys Lys Asn Lys Phe Ala Asn 
            820                  825                830        
Thr Met Glu Phe Val Glu Asp Tyr Leu Asn Asn Val Val Ser Glu Ala 
        835                  840                845            
Val Pro Phe Ala Asn Glu Glu Lys Asn Lys Leu Thr Phe Glu Val Val 
    850                  855                860                
Ser Leu Ala His Asn Leu Ile Tyr Phe Gly Phe Tyr Ser Phe Ser Glu 
865                  870                875                  880
Leu Leu Arg Leu Thr Arg Thr Leu Leu Gly Ile Ile Asp Cys Val Gln 
                885                  890                895    
Gly Pro Pro Ala Met Leu Gln Ala Tyr Glu Asp Pro Gly Gly Lys Asn 
            900                  905                910        
Val Arg Arg Ser Ile Gln Gly Val Gly His Met Met Ser Thr Met Val 
        915                  920                925            
Leu Ser Arg Lys Gln Ser Val Phe Ser Ala Pro Ser Leu Ser Ala Gly 
    930                  935                940                
Ala Ser Ala Ala Glu Pro Leu Asp Arg Ser Lys Phe Glu Glu Asn Glu 
945                  950                955                  960
Asp Ile Val Val Met Glu Thr Lys Leu Lys Ile Leu Glu Ile Leu Gln 
                965                  970                975    
Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser Tyr Leu Leu Ser 
            980                  985                990        
Val Phe Lys Lys Glu Phe Val Glu Val Phe Pro Met Gln Asp Ser Gly 
        995                  1000                1005            
Ala Asp Gly Thr Ala Pro Ala Phe Asp Ser Thr Thr Ala Asn Met Asn 
    1010                1015                1020                
Leu Asp Arg Ile Gly Glu Gln Ala Glu Ala Met Phe Gly Val Gly Lys 
1025                1030                1035                1040
Thr Ser Ser Met Leu Glu Val Asp Asp Glu Gly Gly Arg Met Phe Leu 
                1045                1050                1055    
Arg Val Leu Ile His Leu Thr Met His Asp Tyr Ala Pro Leu Val Ser 
            1060                1065                1070        
Gly Ala Leu Gln Leu Leu Phe Lys His Phe Ser Gln Arg Gln Glu Ala 
        1075                1080                1085            
Met His Thr Phe Lys Gln Val Gln Leu Leu Ile Ser Ala Gln Asp Val 
    1090                1095                1100                
Glu Asn Tyr Lys Val Ile Lys Ser Glu Leu Asp Arg Leu Arg Thr Met 
1105                1110                1115                1120
Val Glu Lys Ser Glu Leu Trp Val Asp Lys Lys Gly Ser Gly Lys Gly 
                1125                1130                1135    
Glu Glu Val Glu Ala Gly Ala Ala Lys Asp Lys Lys Glu Arg Pro Thr 
            1140                1145                1150        
Asp Glu Glu Gly Phe Leu His Pro Pro Gly Glu Lys Ser Ser Glu Asn 
        1155                1160                1165            
Tyr Gln Ile Val Lys Gly Ile Leu Glu Arg Leu Asn Lys Met Cys Gly 
    1170                1175                1180                
Val Gly Glu Gln Met Arg Lys Lys Gln Gln Arg Leu Leu Lys Asn Met 
1185                1190                1195                1200
Asp Ala His Lys Val Met Leu Asp Leu Leu Gln Ile Pro Tyr Asp Lys 
                1205                1210                1215    
Gly Asp Ala Lys Met Met Glu Ile Leu Arg Tyr Thr His Gln Phe Leu 
            1220                1225                1230        
Gln Lys Phe Cys Ala Gly Asn Pro Gly Asn Gln Ala Leu Leu His Lys 
        1235                1240                1245            
His Leu His Leu Phe Leu Thr Pro Gly Leu Leu Glu Ala Glu Thr Met 
    1250                1255                1260                
Gln His Ile Phe Leu Asn Asn Tyr Gln Leu Cys Ser Glu Ile Ser Glu 
1265                1270                1275                1280
Pro Val Leu Gln His Phe Val His Leu Leu Ala Thr His Gly Arg His 
                1285                1290                1295    
Val Gln Tyr Leu Asp Phe Leu His Thr Val Ile Lys Ala Glu Gly Lys 
            1300                1305                1310        
Tyr Val Lys Lys Cys Gln Asp Met Ile Met Thr Glu Leu Thr Asn Ala 
        1315                1320                1325            
Gly Asp Asp Val Val Val Phe Tyr Asn Asp Lys Ala Ser Leu Ala His 
    1330                1335                1340                
Leu Leu Asp Met Met Lys Ala Ala Arg Asp Gly Val Glu Asp His Ser 
1345                1350                1355                1360
Pro Leu Met Tyr His Ile Ser Leu Val Asp Leu Leu Ala Ala Cys Ala 
                1365                1370                1375    
Glu Gly Lys Asn Val Tyr Thr Glu Ile Lys Cys Thr Ser Leu Leu Pro 
            1380                1385                1390        
Leu Glu Asp Val Val Ser Val Val Thr His Glu Asp Cys Ile Thr Glu 
        1395                1400                1405            
Val Lys Met Ala Tyr Val Asn Phe Val Asn His Cys Tyr Val Asp Thr 
    1410                1415                1420                
Glu Val Glu Met Lys Glu Ile Tyr Thr Ser Asn His Ile Trp Thr Leu 
1425                1430                1435                1440
Phe Glu Asn Phe Thr Leu Asp Met Ala Arg Val Cys Ser Lys Arg Glu 
                1445                1450                1455    
Lys Arg Val Ala Asp Pro Thr Leu Glu Lys Tyr Val Leu Ser Val Val 
            1460                1465                1470        
Leu Asp Thr Ile Asn Ala Phe Phe Ser Ser Pro Phe Ser Glu Asn Ser 
        1475                1480                1485            
Thr Ser Leu Gln Thr His Gln Thr Ile Val Val Gln Leu Leu Gln Ser 
    1490                1495                1500                
Thr Thr Arg Leu Leu Glu Cys Pro Trp Leu Gln Gln Gln His Lys Gly 
1505                1510                1515                1520
Ser Val Glu Ala Cys Ile Arg Thr Leu Ala Met Val Ala Lys Gly Arg 
                1525                1530                1535    
Ala Ile Leu Leu Pro Met Asp Leu Asp Ala His Ile Ser Ser Met Leu 
            1540                1545                1550        
Ser Ser Gly Ala Ser Cys Ala Ala Ala Ala Gln Arg Asn Ala Ser Ser 
        1555                1560                1565            
Tyr Lys Ala Thr Thr Arg Ala Phe Pro Arg Val Thr Pro Thr Ala Asn 
    1570                1575                1580                
Gln Trp Asp Tyr Lys Asn Ile Ile Glu Lys Leu Gln Asp Ile Ile Thr 
1585                1590                1595                1600
Ala Leu Glu Glu Arg Leu Lys Pro Leu Val Gln Ala Glu Leu Ser Val 
                1605                1610                1615    
Leu Val Asp Val Leu His Trp Pro Glu Leu Leu Phe Leu Glu Gly Ser 
            1620                1625                1630        
Glu Ala Tyr Gln Arg Cys Glu Ser Gly Gly Phe Leu Ser Lys Leu Ile 
        1635                1640                1645            
Gln His Thr Lys Asp Leu Met Glu Ser Glu Glu Lys Leu Cys Ile Lys 
    1650                1655                1660                
Val Leu Arg Thr Leu Gln Gln Met Leu Leu Lys Lys Thr Lys Tyr Gly 
1665                1670                1675                1680
Asp Arg Gly Asn Gln Leu Arg Lys Met Leu Leu Gln Asn Tyr Leu Gln 
                1685                1690                1695    
Asn Arg Lys Ser Thr Ser Arg Gly Asp Leu Pro Asp Pro Ile Gly Thr 
            1700                1705                1710        
Gly Leu Asp Pro Asp Trp Ser Ala Ile Ala Ala Thr Gln Cys Arg Leu 
        1715                1720                1725            
Asp Lys Glu Gly Ala Thr Lys Leu Val Cys Asp Leu Ile Thr Ser Thr 
    1730                1735                1740                
Lys Asn Glu Lys Ile Phe Gln Glu Ser Ile Gly Leu Ala Ile His Leu 
1745                1750                1755                1760
Leu Asp Gly Gly Asn Thr Glu Ile Gln Lys Ser Phe His Asn Leu Met 
                1765                1770                1775    
Met Ser Asp Lys Lys Ser Glu Arg Phe Phe Lys Val Leu His Asp Arg 
            1780                1785                1790        
Met Lys Arg Ala Gln Gln Glu Thr Lys Ser Thr Val Ala Val Asn Met 
        1795                1800                1805            
Asn Asp Leu Gly Ser Gln Pro His Glu Asp Arg Glu Pro Val Asp Pro 
    1810                1815                1820                
Thr Thr Lys Gly Arg Val Ala Ser Phe Ser Ile Pro Gly Ser Ser Ser 
1825                1830                1835                1840
Arg Tyr Ser Leu Gly Pro Ser Leu Arg Arg Gly His Glu Val Ser Glu 
                1845                1850                1855    
Arg Val Gln Ser Ser Glu Met Gly Thr Ser Val Leu Ile Met Gln Pro 
            1860                1865                1870        
Ile Leu Arg Phe Leu Gln Leu Leu Cys Glu Asn His Asn Arg Asp Leu 
        1875                1880                1885            
Gln Asn Phe Leu Arg Cys Gln Asn Asn Lys Thr Asn Tyr Asn Leu Val 
    1890                1895                1900                
Cys Glu Thr Leu Gln Phe Leu Asp Ile Met Cys Gly Ser Thr Thr Gly 
1905                1910                1915                1920
Gly Leu Gly Leu Leu Gly Leu Tyr Ile Asn Glu Asp Asn Val Gly Leu 
                1925                1930                1935    
Val Ile Gln Thr Leu Glu Thr Leu Thr Glu Tyr Cys Gln Gly Pro Cys 
            1940                1945                1950        
His Glu Asn Gln Thr Cys Ile Val Thr His Glu Ser Asn Gly Ile Asp 
        1955                1960                1965            
Ile Ile Thr Ala Leu Ile Leu Asn Asp Ile Ser Pro Leu Cys Lys Tyr 
    1970                1975                1980                
Arg Met Asp Leu Val Leu Gln Leu Lys Asp Asn Ala Ser Lys Leu Leu 
1985                1990                1995                2000
Leu Ala Leu Met Glu Ser Arg His Asp Ser Glu Asn Ala Glu Arg Ile 
                2005                2010                2015    
Leu Ile Ser Leu Arg Pro Gln Glu Leu Val Asp Val Ile Lys Lys Ala 
            2020                2025                2030        
Tyr Leu Gln Glu Glu Glu Arg Glu Asn Ser Glu Val Ser Pro Arg Glu 
        2035                2040                2045            
Val Gly His Asn Ile Tyr Ile Leu Ala Leu Gln Leu Ser Arg His Asn 
    2050                2055                2060                
Lys Gln Leu Gln His Leu Leu Lys Pro Val Lys Arg Ile Gln Glu Glu 
2065                2070                2075                2080
Glu Ala Glu Gly Ile Ser Ser Met Leu Ser Leu Asn Asn Lys Gln Leu 
                2085                2090                2095    
Ser Gln Met Leu Lys Ser Ser Ala Pro Ala Gln Glu Glu Glu Glu Asp 
            2100                2105                2110        
Pro Leu Ala Tyr Tyr Glu Asn His Thr Ser Gln Ile Glu Ile Val Arg 
        2115                2120                2125            
Gln Asp Arg Ser Met Glu Gln Ile Val Phe Pro Val Pro Gly Ile Cys 
    2130                2135                2140                
Gln Phe Leu Thr Glu Glu Thr Lys His Arg Leu Phe Thr Thr Thr Glu 
2145                2150                2155                2160
Gln Asp Glu Gln Gly Ser Lys Val Ser Asp Phe Phe Asp Gln Ser Ser 
                2165                2170                2175    
Phe Leu His Asn Glu Met Glu Trp Gln Arg Lys Leu Arg Ser Met Pro 
            2180                2185                2190        
Leu Ile Tyr Trp Phe Ser Arg Arg Met Thr Leu Trp Gly Ser Ile Ser 
        2195                2200                2205            
Phe Asn Leu Ala Val Phe Ile Asn Ile Ile Ile Ala Phe Phe Tyr Pro 
    2210                2215                2220                
Tyr Met Glu Gly Ala Ser Thr Gly Val Leu Asp Ser Pro Leu Ile Ser 
2225                2230                2235                2240
Leu Leu Phe Trp Ile Leu Ile Cys Phe Ser Ile Ala Ala Leu Phe Thr 
                2245                2250                2255    
Lys Arg Tyr Ser Ile Arg Pro Leu Ile Val Ala Leu Ile Leu Arg Ser 
            2260                2265                2270        
Ile Tyr Tyr Leu Gly Ile Gly Pro Thr Leu Asn Ile Leu Gly Ala Leu 
        2275                2280                2285            
Asn Leu Thr Asn Lys Ile Val Phe Val Val Ser Phe Val Gly Asn Arg 
    2290                2295                2300                
Gly Thr Phe Ile Arg Gly Tyr Lys Ala Met Val Met Asp Met Glu Phe 
2305                2310                2315                2320
Leu Tyr His Val Gly Tyr Ile Leu Thr Ser Val Leu Gly Leu Phe Ala 
                2325                2330                2335    
His Glu Leu Phe Tyr Ser Ile Leu Leu Phe Asp Leu Ile Tyr Arg Glu 
            2340                2345                2350        
Glu Thr Leu Phe Asn Val Ile Lys Ser Val Thr Arg Asn Gly Arg Ser 
        2355                2360                2365            
Ile Leu Leu Thr Ala Leu Leu Ala Leu Ile Leu Val Tyr Leu Phe Ser 
    2370                2375                2380                
Ile Val Gly Phe Leu Phe Leu Lys Asp Asp Phe Ile Leu Glu Val Asp 
2385                2390                2395                2400
Arg Leu Pro Asn Asn His Ser Thr Ala Ser Pro Leu Gly Met Pro His 
                2405                2410                2415    
Gly Ala Ala Ala Phe Val Asp Thr Cys Ser Gly Asp Lys Met Asp Cys 
            2420                2425                2430        
Val Ser Gly Leu Ser Val Pro Glu Val Leu Glu Glu Asp Arg Glu Leu 
        2435                2440                2445            
Asp Ser Thr Glu Arg Ala Cys Asp Thr Leu Leu Met Cys Ile Val Thr 
    2450                2455                2460                
Val Met Asn His Gly Leu Arg Asn Gly Gly Gly Val Gly Asp Ile Leu 
2465                2470                2475                2480
Arg Lys Pro Ser Lys Asp Glu Ser Leu Phe Pro Ala Arg Val Val Tyr 
                2485                2490                2495    
Asp Leu Leu Phe Phe Phe Ile Val Ile Ile Ile Val Leu Asn Leu Ile 
            2500                2505                2510        
Phe Gly Val Ile Ile Asp Thr Phe Ala Asp Leu Arg Ser Glu Lys Gln 
        2515                2520                2525            
Lys Lys Glu Glu Ile Leu Lys Thr Thr Cys Phe Ile Cys Gly Leu Glu 
    2530                2535                2540                
Arg Asp Lys Phe Asp Asn Lys Thr Val Ser Phe Glu Glu His Ile Lys 
2545                2550                2555                2560
Leu Glu His Asn Met Trp Asn Tyr Leu Tyr Phe Ile Val Leu Val Arg 
                2565                2570                2575    
Val Lys Asn Lys Thr Asp Tyr Thr Gly Pro Glu Ser Tyr Val Ala Gln 
            2580                2585                2590        
Met Ile Lys Asn Lys Asn Leu Asp Trp Phe Pro Arg Met Arg Ala Met 
        2595                2600                2605            
Ser Leu Val Ser Asn Glu Gly Glu Gly Glu Gln Asn Glu Ile Arg Ile 
    2610                2615                2620                
Leu Gln Asp Lys Leu Asn Ser Thr Met Lys Leu Val Ser His Leu Thr 
2625                2630                2635                2640
Ala Gln Leu Asn Glu Leu Lys Glu Gln Met Thr Glu Gln Arg Lys Arg 
                2645                2650                2655    
Arg Gln Arg Leu Gly Phe Val Asp Val Gln Asn Cys Ile Ser Arg 
            2660                2665                2670    

<210> 12
<211> 1729
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1729
<223> /mol_type="protein"
      /note="Uniprot accession number Q9C0C2"
      /organism="Homo sapiens"

<400> 12
Met Lys Val Ser Thr Leu Arg Glu Ser Ser Ala Met Ala Ser Pro Leu 
1               5                   10                   15    
Pro Arg Glu Met Glu Glu Glu Leu Val Pro Thr Gly Ser Glu Pro Gly 
            20                   25                  30        
Asp Thr Arg Ala Lys Pro Pro Val Lys Pro Lys Pro Arg Ala Leu Pro 
        35                   40                  45            
Ala Lys Pro Ala Leu Pro Ala Lys Pro Ser Leu Leu Val Pro Val Gly 
    50                   55                  60                
Pro Arg Pro Pro Arg Gly Pro Leu Ala Glu Leu Pro Ser Ala Arg Lys 
65                   70                  75                  80
Met Asn Met Leu Ala Gly Pro Gln Pro Tyr Gly Gly Ser Lys Arg Pro 
                85                   90                  95    
Leu Pro Phe Ala Pro Arg Pro Ala Val Glu Ala Ser Thr Gly Gly Glu 
            100                  105                110        
Ala Thr Gln Glu Thr Gly Lys Glu Glu Ala Gly Lys Glu Glu Pro Pro 
        115                  120                125            
Pro Leu Thr Pro Pro Ala Arg Cys Ala Ala Pro Gly Gly Val Arg Lys 
    130                  135                140                
Ala Pro Ala Pro Phe Arg Pro Ala Ser Glu Arg Phe Ala Ala Thr Thr 
145                  150                155                  160
Val Glu Glu Ile Leu Ala Lys Met Glu Gln Pro Arg Lys Glu Val Leu 
                165                  170                175    
Ala Ser Pro Asp Arg Leu Trp Gly Ser Arg Leu Thr Phe Asn His Asp 
            180                  185                190        
Gly Ser Ser Arg Tyr Gly Pro Arg Thr Tyr Gly Thr Thr Thr Ala Pro 
        195                  200                205            
Arg Asp Glu Asp Gly Ser Thr Leu Phe Arg Gly Trp Ser Gln Glu Gly 
    210                  215                220                
Pro Val Lys Ser Pro Ala Glu Cys Arg Glu Glu His Ser Lys Thr Pro 
225                  230                235                  240
Glu Glu Arg Ser Leu Pro Ser Asp Leu Ala Phe Asn Gly Asp Leu Ala 
                245                  250                255    
Lys Ala Ala Ser Ser Glu Leu Pro Ala Asp Ile Ser Lys Pro Trp Ile 
            260                  265                270        
Pro Ser Ser Pro Ala Pro Ser Ser Glu Asn Gly Gly Pro Ala Ser Pro 
        275                  280                285            
Gly Leu Pro Ala Glu Ala Ser Gly Ser Gly Pro Gly Ser Pro His Leu 
    290                  295                300                
His Pro Pro Asp Lys Ser Ser Pro Cys His Ser Gln Leu Leu Glu Ala 
305                  310                315                  320
Gln Thr Pro Glu Ala Ser Gln Ala Ser Pro Cys Pro Ala Val Thr Pro 
                325                  330                335    
Ser Ala Pro Ser Ala Ala Leu Pro Asp Glu Gly Ser Arg His Thr Pro 
            340                  345                350        
Ser Pro Gly Leu Pro Ala Glu Gly Ala Pro Glu Ala Pro Arg Pro Ser 
        355                  360                365            
Ser Pro Pro Pro Glu Val Leu Glu Pro His Ser Leu Asp Gln Pro Pro 
    370                  375                380                
Ala Thr Ser Pro Arg Pro Leu Ile Glu Val Gly Glu Leu Leu Asp Leu 
385                  390                395                  400
Thr Arg Thr Phe Pro Ser Gly Gly Glu Glu Glu Ala Lys Gly Asp Ala 
                405                  410                415    
His Leu Arg Pro Thr Ser Leu Val Gln Arg Arg Phe Ser Glu Gly Val 
            420                  425                430        
Leu Gln Ser Pro Ser Gln Asp Gln Glu Lys Leu Gly Gly Ser Leu Ala 
        435                  440                445            
Ala Leu Pro Gln Gly Gln Gly Ser Gln Leu Ala Leu Asp Arg Pro Phe 
    450                  455                460                
Gly Ala Glu Ser Asn Trp Ser Leu Ser Gln Ser Phe Glu Trp Thr Phe 
465                  470                475                  480
Pro Thr Arg Pro Ser Gly Leu Gly Val Trp Arg Leu Asp Ser Pro Pro 
                485                  490                495    
Pro Ser Pro Ile Thr Glu Ala Ser Glu Ala Ala Glu Ala Ala Glu Ala 
            500                  505                510        
Gly Asn Leu Ala Val Ser Ser Arg Glu Glu Gly Val Ser Gln Gln Gly 
        515                  520                525            
Gln Gly Ala Gly Ser Ala Pro Ser Gly Ser Gly Ser Ser Trp Val Gln 
    530                  535                540                
Gly Asp Asp Pro Ser Met Ser Leu Thr Gln Lys Gly Asp Gly Glu Ser 
545                  550                555                  560
Gln Pro Gln Phe Pro Ala Val Pro Leu Glu Pro Leu Pro Thr Thr Glu 
                565                  570                575    
Gly Thr Pro Gly Leu Pro Leu Gln Gln Ala Glu Glu Arg Tyr Glu Ser 
            580                  585                590        
Gln Glu Pro Leu Ala Gly Gln Glu Ser Pro Leu Pro Leu Ala Thr Arg 
        595                  600                605            
Glu Ala Ala Leu Pro Ile Leu Glu Pro Val Leu Gly Gln Glu Gln Pro 
    610                  615                620                
Ala Ala Pro Asp Gln Pro Cys Val Leu Phe Ala Asp Ala Pro Glu Pro 
625                  630                635                  640
Gly Gln Ala Leu Pro Val Glu Glu Glu Ala Val Thr Leu Ala Arg Ala 
                645                  650                655    
Glu Thr Thr Gln Ala Arg Thr Glu Ala Gln Asp Leu Cys Arg Ala Ser 
            660                  665                670        
Pro Glu Pro Pro Gly Pro Glu Ser Ser Ser Arg Trp Leu Asp Asp Leu 
        675                  680                685            
Leu Ala Ser Pro Pro Pro Ser Gly Gly Gly Ala Arg Arg Gly Ala Gly 
    690                  695                700                
Ala Glu Leu Lys Asp Thr Gln Ser Pro Ser Thr Cys Ser Glu Gly Leu 
705                  710                715                  720
Leu Gly Trp Ser Gln Lys Asp Leu Gln Ser Glu Phe Gly Ile Thr Gly 
                725                  730                735    
Asp Pro Gln Pro Ser Ser Phe Ser Pro Ser Ser Trp Cys Gln Gly Ala 
            740                  745                750        
Ser Gln Asp Tyr Gly Leu Gly Gly Ala Ser Pro Arg Gly Asp Pro Gly 
        755                  760                765            
Leu Gly Glu Arg Asp Trp Thr Ser Lys Tyr Gly Gln Gly Ala Gly Glu 
    770                  775                780                
Gly Ser Thr Arg Glu Trp Ala Ser Arg Cys Gly Ile Gly Gln Glu Glu 
785                  790                795                  800
Met Glu Ala Ser Ser Ser Gln Asp Gln Ser Lys Val Ser Ala Pro Gly 
                805                  810                815    
Val Leu Thr Ala Gln Asp Arg Val Val Gly Lys Pro Ala Gln Leu Gly 
            820                  825                830        
Thr Gln Arg Ser Gln Glu Ala Asp Val Gln Asp Trp Glu Phe Arg Lys 
        835                  840                845            
Arg Asp Ser Gln Gly Thr Tyr Ser Ser Arg Asp Ala Glu Leu Gln Asp 
    850                  855                860                
Gln Glu Phe Gly Lys Arg Asp Ser Leu Gly Thr Tyr Ser Ser Arg Asp 
865                  870                875                  880
Val Ser Leu Gly Asp Trp Glu Phe Gly Lys Arg Asp Ser Leu Gly Ala 
                885                  890                895    
Tyr Ala Ser Gln Asp Ala Asn Glu Gln Gly Gln Asp Leu Gly Lys Arg 
            900                  905                910        
Asp His His Gly Arg Tyr Ser Ser Gln Asp Ala Asp Glu Gln Asp Trp 
        915                  920                925            
Glu Phe Gln Lys Arg Asp Val Ser Leu Gly Thr Tyr Gly Ser Arg Ala 
    930                  935                940                
Ala Glu Pro Gln Glu Gln Glu Phe Gly Lys Ser Ala Trp Ile Arg Asp 
945                  950                955                  960
Tyr Ser Ser Gly Gly Ser Ser Arg Thr Leu Asp Ala Gln Asp Arg Ser 
                965                  970                975    
Phe Gly Thr Arg Pro Leu Ser Ser Gly Phe Ser Pro Glu Glu Ala Gln 
            980                  985                990        
Gln Gln Asp Glu Glu Phe Glu Lys Lys Ile Pro Ser Val Glu Asp Ser 
        995                  1000                1005            
Leu Gly Glu Gly Ser Arg Asp Ala Gly Arg Pro Gly Glu Arg Gly Ser 
    1010                1015                1020                
Gly Gly Leu Phe Ser Pro Ser Thr Ala His Val Pro Asp Gly Ala Leu 
1025                1030                1035                1040
Gly Gln Arg Asp Gln Ser Ser Trp Gln Asn Ser Asp Ala Ser Gln Glu 
                1045                1050                1055    
Val Gly Gly His Gln Glu Arg Gln Gln Ala Gly Ala Gln Gly Pro Gly 
            1060                1065                1070        
Ser Ala Asp Leu Glu Asp Gly Glu Met Gly Lys Arg Gly Trp Val Gly 
        1075                1080                1085            
Glu Phe Ser Leu Ser Val Gly Pro Gln Arg Glu Ala Ala Phe Ser Pro 
    1090                1095                1100                
Gly Gln Gln Asp Trp Ser Arg Asp Phe Cys Ile Glu Ala Ser Glu Arg 
1105                1110                1115                1120
Ser Tyr Gln Phe Gly Ile Ile Gly Asn Asp Arg Val Ser Gly Ala Gly 
                1125                1130                1135    
Phe Ser Pro Ser Ser Lys Met Glu Gly Gly His Phe Val Pro Pro Gly 
            1140                1145                1150        
Lys Thr Thr Ala Gly Ser Val Asp Trp Thr Asp Gln Leu Gly Leu Arg 
        1155                1160                1165            
Asn Leu Glu Val Ser Ser Cys Val Gly Ser Gly Gly Ser Ser Glu Ala 
    1170                1175                1180                
Arg Glu Ser Ala Val Gly Gln Met Gly Trp Ser Gly Gly Leu Ser Leu 
1185                1190                1195                1200
Arg Asp Met Asn Leu Thr Gly Cys Leu Glu Ser Gly Gly Ser Glu Glu 
                1205                1210                1215    
Pro Gly Gly Ile Gly Val Gly Glu Lys Asp Trp Thr Ser Asp Val Asn 
            1220                1225                1230        
Val Lys Ser Lys Asp Leu Ala Glu Val Gly Glu Gly Gly Gly His Ser 
        1235                1240                1245            
Gln Ala Arg Glu Ser Gly Val Gly Gln Thr Asp Trp Ser Gly Val Glu 
    1250                1255                1260                
Ala Gly Glu Phe Leu Lys Ser Arg Glu Arg Gly Val Gly Gln Ala Asp 
1265                1270                1275                1280
Trp Thr Pro Asp Leu Gly Leu Arg Asn Met Ala Pro Gly Ala Val Cys 
                1285                1290                1295    
Ser Pro Gly Glu Ser Lys Glu Leu Gly Val Gly Gln Met Asp Trp Gly 
            1300                1305                1310        
Asn Asn Leu Gly Leu Arg Asp Leu Glu Val Thr Cys Asp Pro Asp Ser 
        1315                1320                1325            
Gly Gly Ser Gln Gly Leu Arg Gly Cys Gly Val Gly Gln Met Asp Trp 
    1330                1335                1340                
Thr Gln Asp Leu Ala Pro Gln Asn Val Glu Leu Phe Gly Ala Pro Ser 
1345                1350                1355                1360
Glu Ala Arg Glu His Gly Val Gly Gly Val Ser Gln Cys Pro Glu Pro 
                1365                1370                1375    
Gly Leu Arg His Asn Gly Ser Leu Ser Pro Gly Leu Glu Ala Arg Asp 
            1380                1385                1390        
Pro Leu Glu Ala Arg Glu Leu Gly Val Gly Glu Thr Ser Gly Pro Glu 
        1395                1400                1405            
Thr Gln Gly Glu Asp Tyr Ser Ser Ser Ser Leu Glu Pro His Pro Ala 
    1410                1415                1420                
Asp Pro Gly Met Glu Thr Gly Glu Ala Leu Ser Phe Gly Ala Ser Pro 
1425                1430                1435                1440
Gly Arg Cys Pro Ala Arg Pro Pro Pro Ser Gly Ser Gln Gly Leu Leu 
                1445                1450                1455    
Glu Glu Met Leu Ala Ala Ser Ser Ser Lys Ala Val Ala Arg Arg Glu 
            1460                1465                1470        
Ser Ala Ala Ser Gly Leu Gly Gly Leu Leu Glu Glu Glu Gly Ala Gly 
        1475                1480                1485            
Ala Gly Ala Ala Gln Glu Glu Val Leu Glu Pro Gly Arg Asp Ser Pro 
    1490                1495                1500                
Pro Ser Trp Arg Pro Gln Pro Asp Gly Glu Ala Ser Gln Thr Glu Asp 
1505                1510                1515                1520
Val Asp Gly Thr Trp Gly Ser Ser Ala Ala Arg Trp Ser Asp Gln Gly 
                1525                1530                1535    
Pro Ala Gln Thr Ser Arg Arg Pro Ser Gln Gly Pro Pro Ala Arg Ser 
            1540                1545                1550        
Pro Ser Gln Asp Phe Ser Phe Ile Glu Asp Thr Glu Ile Leu Asp Ser 
        1555                1560                1565            
Ala Met Tyr Arg Ser Arg Ala Asn Leu Gly Arg Lys Arg Gly His Arg 
    1570                1575                1580                
Ala Pro Val Ile Arg Pro Gly Gly Thr Leu Gly Leu Ser Glu Ala Ala 
1585                1590                1595                1600
Asp Ser Asp Ala His Leu Phe Gln Asp Ser Thr Glu Pro Arg Ala Ser 
                1605                1610                1615    
Arg Val Pro Ser Ser Asp Glu Glu Val Val Glu Glu Pro Gln Ser Arg 
            1620                1625                1630        
Arg Thr Arg Met Ser Leu Gly Thr Lys Gly Leu Lys Val Asn Leu Phe 
        1635                1640                1645            
Pro Gly Leu Ser Pro Ser Ala Leu Lys Ala Lys Leu Arg Pro Arg Asn 
    1650                1655                1660                
Arg Ser Ala Glu Glu Gly Glu Leu Ala Glu Ser Lys Ser Ser Gln Lys 
1665                1670                1675                1680
Glu Ser Ala Val Gln Arg Ser Lys Ser Cys Lys Val Pro Gly Leu Gly 
                1685                1690                1695    
Lys Pro Leu Thr Leu Pro Pro Lys Pro Glu Lys Ser Ser Gly Ser Glu 
            1700                1705                1710        
Gly Ser Ser Pro Asn Trp Leu Gln Ala Leu Lys Leu Lys Lys Lys Lys 
        1715                1720                1725            
Val 
    

<210> 13
<211> 1173
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1173
<223> /mol_type="protein"
      /note="Uniprot accession number Q6ZSZ5"
      /organism="Homo sapiens"

<400> 13
Met Val Thr Val Gly Thr Asn Ile Leu Pro Ser Arg Pro Ala Ala Ser 
1               5                   10                   15    
Ala Asn Thr Ala Arg Glu Asp Ala Ala Leu Phe Ser Arg Arg Ile Pro 
            20                   25                  30        
Pro Arg His Lys Asn Gly Ala Ala Gln Pro Gly Ala Ala Pro Gly Pro 
        35                   40                  45            
Gly Ala Pro Gly Ala Asn Met Gly Asn Ala His Ser Lys Ser Gly Asp 
    50                   55                  60                
Arg His Ser Ala Leu Pro Gly Arg Pro Glu Leu Ser Phe Tyr Gly Ser 
65                   70                  75                  80
Phe Pro Arg Lys Trp Ser Glu Asn Val Phe Leu Asp Asn Glu Leu Leu 
                85                   90                  95    
Thr Ser Lys Ile Leu Ser Val Leu Arg Pro Gln Ser Glu Arg Gly Phe 
            100                  105                110        
Arg Ala Gly Asp Leu Arg Tyr Pro Thr His Phe Leu Ser Thr Asn Ser 
        115                  120                125            
Val Leu Ala Ser Val Thr Ala Ser Leu Lys Glu His Pro Arg Gly Thr 
    130                  135                140                
Leu Leu Ser Asp Gly Ser Pro Ala Leu Ser Arg Asn Val Gly Met Thr 
145                  150                155                  160
Val Ser Gln Lys Gly Gly Pro Gln Pro Thr Pro Ser Pro Ala Gly Pro 
                165                  170                175    
Gly Thr Gln Leu Gly Pro Ile Thr Gly Glu Met Asp Glu Ala Asp Ser 
            180                  185                190        
Ala Phe Leu Lys Phe Lys Gln Thr Ala Asp Asp Ser Leu Ser Leu Thr 
        195                  200                205            
Ser Pro Asn Thr Glu Ser Ile Phe Val Glu Asp Pro Tyr Thr Ala Ser 
    210                  215                220                
Leu Arg Ser Glu Ile Glu Ser Asp Gly His Glu Phe Glu Ala Glu Ser 
225                  230                235                  240
Trp Ser Leu Ala Val Asp Ala Ala Tyr Ala Lys Lys Gln Lys Arg Glu 
                245                  250                255    
Val Val Lys Arg Gln Asp Val Leu Tyr Glu Leu Met Gln Thr Glu Val 
            260                  265                270        
His His Val Arg Thr Leu Lys Ile Met Leu Lys Val Tyr Ser Arg Ala 
        275                  280                285            
Leu Gln Glu Glu Leu Gln Phe Ser Ser Lys Ala Ile Gly Arg Leu Phe 
    290                  295                300                
Pro Cys Ala Asp Asp Leu Leu Glu Thr His Ser His Phe Leu Ala Arg 
305                  310                315                  320
Leu Lys Glu Arg Arg Gln Glu Ser Leu Glu Glu Gly Ser Asp Arg Asn 
                325                  330                335    
Tyr Val Ile Gln Lys Ile Gly Asp Leu Leu Val Gln Gln Phe Ser Gly 
            340                  345                350        
Glu Asn Gly Glu Arg Met Lys Glu Lys Tyr Gly Val Phe Cys Ser Gly 
        355                  360                365            
His Asn Glu Ala Val Ser His Tyr Lys Leu Leu Leu Gln Gln Asn Lys 
    370                  375                380                
Lys Phe Gln Asn Leu Ile Lys Lys Ile Gly Asn Phe Ser Ile Val Arg 
385                  390                395                  400
Arg Leu Gly Val Gln Glu Cys Ile Leu Leu Val Thr Gln Arg Ile Thr 
                405                  410                415    
Lys Tyr Pro Val Leu Val Glu Arg Ile Ile Gln Asn Thr Glu Ala Gly 
            420                  425                430        
Thr Glu Asp Tyr Glu Asp Leu Thr Gln Ala Leu Asn Leu Ile Lys Asp 
        435                  440                445            
Ile Ile Ser Gln Val Asp Ala Lys Val Ser Glu Cys Glu Lys Gly Gln 
    450                  455                460                
Arg Leu Arg Glu Ile Ala Gly Lys Met Asp Leu Lys Ser Ser Ser Lys 
465                  470                475                  480
Leu Lys Asn Gly Leu Thr Phe Arg Lys Glu Asp Met Leu Gln Arg Gln 
                485                  490                495    
Leu His Leu Glu Gly Met Leu Cys Trp Lys Thr Thr Ser Gly Arg Leu 
            500                  505                510        
Lys Asp Ile Leu Ala Ile Leu Leu Thr Asp Val Leu Leu Leu Leu Gln 
        515                  520                525            
Glu Lys Asp Gln Lys Tyr Val Phe Ala Ser Val Asp Ser Lys Pro Pro 
    530                  535                540                
Val Ile Ser Leu Gln Lys Leu Ile Val Arg Glu Val Ala Asn Glu Glu 
545                  550                555                  560
Lys Ala Met Phe Leu Ile Ser Ala Ser Leu Gln Gly Pro Glu Met Tyr 
                565                  570                575    
Glu Ile Tyr Thr Ser Ser Lys Glu Asp Arg Asn Ala Trp Met Ala His 
            580                  585                590        
Ile Gln Arg Ala Val Glu Ser Cys Pro Asp Glu Glu Glu Gly Pro Phe 
        595                  600                605            
Ser Leu Pro Glu Glu Glu Arg Lys Val Val Glu Ala Arg Ala Thr Arg 
    610                  615                620                
Leu Arg Asp Phe Gln Glu Arg Leu Ser Met Lys Asp Gln Leu Ile Ala 
625                  630                635                  640
Gln Ser Leu Leu Glu Lys Gln Gln Ile Tyr Leu Glu Met Ala Glu Met 
                645                  650                655    
Gly Gly Leu Glu Asp Leu Pro Gln Pro Arg Gly Leu Phe Arg Gly Gly 
            660                  665                670        
Asp Pro Ser Glu Thr Leu Gln Gly Glu Leu Ile Leu Lys Ser Ala Met 
        675                  680                685            
Ser Glu Ile Glu Gly Ile Gln Ser Leu Ile Cys Arg Gln Leu Gly Ser 
    690                  695                700                
Ala Asn Gly Gln Ala Glu Asp Gly Gly Ser Ser Thr Gly Pro Pro Arg 
705                  710                715                  720
Arg Ala Glu Thr Phe Ala Gly Tyr Asp Cys Thr Asn Ser Pro Thr Lys 
                725                  730                735    
Asn Gly Ser Phe Lys Lys Lys Val Ser Ser Thr Asp Pro Arg Pro Arg 
            740                  745                750        
Asp Trp Arg Gly Pro Pro Asn Ser Pro Asp Leu Lys Leu Ser Asp Ser 
        755                  760                765            
Asp Ile Pro Gly Ser Ser Glu Glu Ser Pro Gln Val Val Glu Ala Pro 
    770                  775                780                
Gly Thr Glu Ser Asp Pro Arg Leu Pro Thr Val Leu Glu Ser Glu Leu 
785                  790                795                  800
Val Gln Arg Ile Gln Thr Leu Ser Gln Leu Leu Leu Asn Leu Gln Ala 
                805                  810                815    
Val Ile Ala His Gln Asp Ser Tyr Val Glu Thr Gln Arg Ala Ala Ile 
            820                  825                830        
Gln Glu Arg Glu Lys Gln Phe Arg Leu Gln Ser Thr Arg Gly Asn Leu 
        835                  840                845            
Leu Leu Glu Gln Glu Arg Gln Arg Asn Phe Glu Lys Gln Arg Glu Glu 
    850                  855                860                
Arg Ala Ala Leu Glu Lys Leu Gln Ser Gln Leu Arg His Glu Gln Gln 
865                  870                875                  880
Arg Trp Glu Arg Glu Arg Gln Trp Gln His Gln Glu Leu Glu Arg Ala 
                885                  890                895    
Gly Ala Arg Leu Gln Glu Arg Glu Gly Glu Ala Arg Gln Leu Arg Glu 
            900                  905                910        
Arg Leu Glu Gln Glu Arg Ala Glu Leu Glu Arg Gln Arg Gln Ala Tyr 
        915                  920                925            
Gln His Asp Leu Glu Arg Leu Arg Glu Ala Gln Arg Ala Val Glu Arg 
    930                  935                940                
Glu Arg Glu Arg Leu Glu Leu Leu Arg Arg Leu Lys Lys Gln Asn Thr 
945                  950                955                  960
Ala Pro Gly Ala Leu Pro Pro Asp Thr Leu Ala Glu Ala Gln Pro Pro 
                965                  970                975    
Ser His Pro Pro Ser Phe Asn Gly Glu Gly Leu Glu Gly Pro Arg Val 
            980                  985                990        
Ser Met Leu Pro Ser Gly Val Gly Pro Glu Tyr Ala Glu Arg Pro Glu 
        995                  1000                1005            
Val Ala Arg Arg Asp Ser Ala Pro Thr Glu Asn Arg Leu Ala Lys Ser 
    1010                1015                1020                
Asp Val Pro Ile Gln Leu Leu Ser Ala Thr Asn Gln Phe Gln Arg Gln 
1025                1030                1035                1040
Ala Ala Val Gln Gln Gln Ile Pro Thr Lys Leu Ala Ala Ser Thr Lys 
                1045                1050                1055    
Gly Gly Lys Asp Lys Gly Gly Lys Ser Arg Gly Ser Gln Arg Trp Glu 
            1060                1065                1070        
Ser Ser Ala Ser Phe Asp Leu Lys Gln Gln Leu Leu Leu Asn Lys Leu 
        1075                1080                1085            
Met Gly Lys Asp Glu Ser Thr Ser Arg Asn Arg Arg Ser Leu Ser Pro 
    1090                1095                1100                
Ile Leu Pro Gly Arg His Ser Pro Ala Pro Pro Pro Asp Pro Gly Phe 
1105                1110                1115                1120
Pro Ala Pro Ser Pro Pro Pro Ala Asp Ser Pro Ser Glu Gly Phe Ser 
                1125                1130                1135    
Leu Lys Ala Gly Gly Thr Ala Leu Leu Pro Gly Pro Pro Ala Pro Ser 
            1140                1145                1150        
Pro Leu Pro Ala Thr Pro Leu Ser Ala Lys Glu Asp Ala Ser Lys Glu 
        1155                1160                1165            
Asp Val Ile Phe Phe 
    1170            

<210> 14
<211> 1015
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1015
<223> /mol_type="protein"
      /note="Uniprot accession number Q6ZSZ5-2"
      /organism="Homo sapiens"

<400> 14
Met Thr Val Ser Gln Lys Gly Gly Pro Gln Pro Thr Pro Ser Pro Ala 
1               5                   10                   15    
Gly Pro Gly Thr Gln Leu Gly Pro Ile Thr Gly Glu Met Asp Glu Ala 
            20                   25                  30        
Asp Ser Ala Phe Leu Lys Phe Lys Gln Thr Ala Asp Asp Ser Leu Ser 
        35                   40                  45            
Leu Thr Ser Pro Asn Thr Glu Ser Ile Phe Val Glu Asp Pro Tyr Thr 
    50                   55                  60                
Ala Ser Leu Arg Ser Glu Ile Glu Ser Asp Gly His Glu Phe Glu Ala 
65                   70                  75                  80
Glu Ser Trp Ser Leu Ala Val Asp Ala Ala Tyr Ala Lys Lys Gln Lys 
                85                   90                  95    
Arg Glu Val Val Lys Arg Gln Asp Val Leu Tyr Glu Leu Met Gln Thr 
            100                  105                110        
Glu Val His His Val Arg Thr Leu Lys Ile Met Leu Lys Val Tyr Ser 
        115                  120                125            
Arg Ala Leu Gln Glu Glu Leu Gln Phe Ser Ser Lys Ala Ile Gly Arg 
    130                  135                140                
Leu Phe Pro Cys Ala Asp Asp Leu Leu Glu Thr His Ser His Phe Leu 
145                  150                155                  160
Ala Arg Leu Lys Glu Arg Arg Gln Glu Ser Leu Glu Glu Gly Ser Asp 
                165                  170                175    
Arg Asn Tyr Val Ile Gln Lys Ile Gly Asp Leu Leu Val Gln Gln Phe 
            180                  185                190        
Ser Gly Glu Asn Gly Glu Arg Met Lys Glu Lys Tyr Gly Val Phe Cys 
        195                  200                205            
Ser Gly His Asn Glu Ala Val Ser His Tyr Lys Leu Leu Leu Gln Gln 
    210                  215                220                
Asn Lys Lys Phe Gln Asn Leu Ile Lys Lys Ile Gly Asn Phe Ser Ile 
225                  230                235                  240
Val Arg Arg Leu Gly Val Gln Glu Cys Ile Leu Leu Val Thr Gln Arg 
                245                  250                255    
Ile Thr Lys Tyr Pro Val Leu Val Glu Arg Ile Ile Gln Asn Thr Glu 
            260                  265                270        
Ala Gly Thr Glu Asp Tyr Glu Asp Leu Thr Gln Ala Leu Asn Leu Ile 
        275                  280                285            
Lys Asp Ile Ile Ser Gln Val Asp Ala Lys Val Ser Glu Cys Glu Lys 
    290                  295                300                
Gly Gln Arg Leu Arg Glu Ile Ala Gly Lys Met Asp Leu Lys Ser Ser 
305                  310                315                  320
Ser Lys Leu Lys Asn Gly Leu Thr Phe Arg Lys Glu Asp Met Leu Gln 
                325                  330                335    
Arg Gln Leu His Leu Glu Gly Met Leu Cys Trp Lys Thr Thr Ser Gly 
            340                  345                350        
Arg Leu Lys Asp Ile Leu Ala Ile Leu Leu Thr Asp Val Leu Leu Leu 
        355                  360                365            
Leu Gln Glu Lys Asp Gln Lys Tyr Val Phe Ala Ser Val Asp Ser Lys 
    370                  375                380                
Pro Pro Val Ile Ser Leu Gln Lys Leu Ile Val Arg Glu Val Ala Asn 
385                  390                395                  400
Glu Glu Lys Ala Met Phe Leu Ile Ser Ala Ser Leu Gln Gly Pro Glu 
                405                  410                415    
Met Tyr Glu Ile Tyr Thr Ser Ser Lys Glu Asp Arg Asn Ala Trp Met 
            420                  425                430        
Ala His Ile Gln Arg Ala Val Glu Ser Cys Pro Asp Glu Glu Glu Gly 
        435                  440                445            
Pro Phe Ser Leu Pro Glu Glu Glu Arg Lys Val Val Glu Ala Arg Ala 
    450                  455                460                
Thr Arg Leu Arg Asp Phe Gln Glu Arg Leu Ser Met Lys Asp Gln Leu 
465                  470                475                  480
Ile Ala Gln Ser Leu Leu Glu Lys Gln Gln Ile Tyr Leu Glu Met Ala 
                485                  490                495    
Glu Met Gly Gly Leu Glu Asp Leu Pro Gln Pro Arg Gly Leu Phe Arg 
            500                  505                510        
Gly Gly Asp Pro Ser Glu Thr Leu Gln Gly Glu Leu Ile Leu Lys Ser 
        515                  520                525            
Ala Met Ser Glu Ile Glu Gly Ile Gln Ser Leu Ile Cys Arg Gln Leu 
    530                  535                540                
Gly Ser Ala Asn Gly Gln Ala Glu Asp Gly Gly Ser Ser Thr Gly Pro 
545                  550                555                  560
Pro Arg Arg Ala Glu Thr Phe Ala Gly Tyr Asp Cys Thr Asn Ser Pro 
                565                  570                575    
Thr Lys Asn Gly Ser Phe Lys Lys Lys Val Ser Ser Thr Asp Pro Arg 
            580                  585                590        
Pro Arg Asp Trp Arg Gly Pro Pro Asn Ser Pro Asp Leu Lys Leu Ser 
        595                  600                605            
Asp Ser Asp Ile Pro Gly Ser Ser Glu Glu Ser Pro Gln Val Val Glu 
    610                  615                620                
Ala Pro Gly Thr Glu Ser Asp Pro Arg Leu Pro Thr Val Leu Glu Ser 
625                  630                635                  640
Glu Leu Val Gln Arg Ile Gln Thr Leu Ser Gln Leu Leu Leu Asn Leu 
                645                  650                655    
Gln Ala Val Ile Ala His Gln Asp Ser Tyr Val Glu Thr Gln Arg Ala 
            660                  665                670        
Ala Ile Gln Glu Arg Glu Lys Gln Phe Arg Leu Gln Ser Thr Arg Gly 
        675                  680                685            
Asn Leu Leu Leu Glu Gln Glu Arg Gln Arg Asn Phe Glu Lys Gln Arg 
    690                  695                700                
Glu Glu Arg Ala Ala Leu Glu Lys Leu Gln Ser Gln Leu Arg His Glu 
705                  710                715                  720
Gln Gln Arg Trp Glu Arg Glu Arg Gln Trp Gln His Gln Glu Leu Glu 
                725                  730                735    
Arg Ala Gly Ala Arg Leu Gln Glu Arg Glu Gly Glu Ala Arg Gln Leu 
            740                  745                750        
Arg Glu Arg Leu Glu Gln Glu Arg Ala Glu Leu Glu Arg Gln Arg Gln 
        755                  760                765            
Ala Tyr Gln His Asp Leu Glu Arg Leu Arg Glu Ala Gln Arg Ala Val 
    770                  775                780                
Glu Arg Glu Arg Glu Arg Leu Glu Leu Leu Arg Arg Leu Lys Lys Gln 
785                  790                795                  800
Asn Thr Ala Pro Gly Ala Leu Pro Pro Asp Thr Leu Ala Glu Ala Gln 
                805                  810                815    
Pro Pro Ser His Pro Pro Ser Phe Asn Gly Glu Gly Leu Glu Gly Pro 
            820                  825                830        
Arg Val Ser Met Leu Pro Ser Gly Val Gly Pro Glu Tyr Ala Glu Arg 
        835                  840                845            
Pro Glu Val Ala Arg Arg Asp Ser Ala Pro Thr Glu Asn Arg Leu Ala 
    850                  855                860                
Lys Ser Asp Val Pro Ile Gln Leu Leu Ser Ala Thr Asn Gln Phe Gln 
865                  870                875                  880
Arg Gln Ala Ala Val Gln Gln Gln Ile Pro Thr Lys Leu Ala Ala Ser 
                885                  890                895    
Thr Lys Gly Gly Lys Asp Lys Gly Gly Lys Ser Arg Gly Ser Gln Arg 
            900                  905                910        
Trp Glu Ser Ser Ala Ser Phe Asp Leu Lys Gln Gln Leu Leu Leu Asn 
        915                  920                925            
Lys Leu Met Gly Lys Asp Glu Ser Thr Ser Arg Asn Arg Arg Ser Leu 
    930                  935                940                
Ser Pro Ile Leu Pro Gly Arg His Ser Pro Ala Pro Pro Pro Asp Pro 
945                  950                955                  960
Gly Phe Pro Ala Pro Ser Pro Pro Pro Ala Asp Ser Pro Ser Glu Gly 
                965                  970                975    
Phe Ser Leu Lys Ala Gly Gly Thr Ala Leu Leu Pro Gly Pro Pro Ala 
            980                  985                990        
Pro Ser Pro Leu Pro Ala Thr Pro Leu Ser Ala Lys Glu Asp Ala Ser 
        995                  1000                1005            
Lys Glu Asp Val Ile Phe Phe 
    1010                1015

<210> 15
<211> 1030
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1030
<223> /mol_type="protein"
      /note="Uniprot accession number Q6ZSZ5-3"
      /organism="Homo sapiens"

<400> 15
Met Thr Val Ser Gln Lys Gly Gly Pro Gln Pro Thr Pro Ser Pro Ala 
1               5                   10                   15    
Gly Pro Gly Thr Gln Leu Gly Pro Ile Thr Gly Glu Met Asp Glu Ala 
            20                   25                  30        
Asp Ser Ala Phe Leu Lys Phe Lys Gln Thr Ala Asp Asp Ser Leu Ser 
        35                   40                  45            
Leu Thr Ser Pro Asn Thr Glu Ser Ile Phe Val Glu Asp Pro Tyr Thr 
    50                   55                  60                
Ala Ser Leu Arg Ser Glu Ile Glu Ser Asp Gly His Glu Phe Glu Ala 
65                   70                  75                  80
Glu Ser Trp Ser Leu Ala Val Asp Ala Ala Tyr Ala Lys Lys Gln Lys 
                85                   90                  95    
Arg Glu Val Val Lys Arg Gln Asp Val Leu Tyr Glu Leu Met Gln Thr 
            100                  105                110        
Glu Val His His Val Arg Thr Leu Lys Ile Met Leu Lys Val Tyr Ser 
        115                  120                125            
Arg Ala Leu Gln Glu Glu Leu Gln Phe Ser Ser Lys Ala Ile Gly Arg 
    130                  135                140                
Leu Phe Pro Cys Ala Asp Asp Leu Leu Glu Thr His Ser His Phe Leu 
145                  150                155                  160
Ala Arg Leu Lys Glu Arg Arg Gln Glu Ser Leu Glu Glu Gly Ser Asp 
                165                  170                175    
Arg Asn Tyr Val Ile Gln Lys Ile Gly Asp Leu Leu Val Gln Gln Phe 
            180                  185                190        
Ser Gly Glu Asn Gly Glu Arg Met Lys Glu Lys Tyr Gly Val Phe Cys 
        195                  200                205            
Ser Gly His Asn Glu Ala Val Ser His Tyr Lys Leu Leu Leu Gln Gln 
    210                  215                220                
Asn Lys Lys Phe Gln Asn Leu Ile Lys Lys Ile Gly Asn Phe Ser Ile 
225                  230                235                  240
Val Arg Arg Leu Gly Val Gln Glu Cys Ile Leu Leu Val Thr Gln Arg 
                245                  250                255    
Ile Thr Lys Tyr Pro Val Leu Val Glu Arg Ile Ile Gln Asn Thr Glu 
            260                  265                270        
Ala Gly Thr Glu Asp Tyr Glu Asp Leu Thr Gln Ala Leu Asn Leu Ile 
        275                  280                285            
Lys Asp Ile Ile Ser Gln Val Asp Ala Lys Val Ser Glu Cys Glu Lys 
    290                  295                300                
Gly Gln Arg Leu Arg Glu Ile Ala Gly Lys Met Asp Leu Lys Ser Ser 
305                  310                315                  320
Ser Lys Leu Lys Asn Gly Leu Thr Phe Arg Lys Glu Asp Met Leu Gln 
                325                  330                335    
Arg Gln Leu His Leu Glu Gly Met Leu Cys Trp Lys Thr Thr Ser Gly 
            340                  345                350        
Arg Leu Lys Asp Ile Leu Ala Ile Leu Leu Thr Asp Val Leu Leu Leu 
        355                  360                365            
Leu Gln Glu Lys Asp Gln Lys Tyr Val Phe Ala Ser Val Asp Ser Lys 
    370                  375                380                
Pro Pro Val Ile Ser Leu Gln Lys Leu Ile Val Arg Glu Val Ala Asn 
385                  390                395                  400
Glu Glu Lys Ala Met Phe Leu Ile Ser Ala Ser Leu Gln Gly Pro Glu 
                405                  410                415    
Met Tyr Glu Ile Tyr Thr Ser Ser Lys Glu Asp Arg Asn Ala Trp Met 
            420                  425                430        
Ala His Ile Gln Arg Ala Val Glu Ser Cys Pro Asp Glu Glu Glu Gly 
        435                  440                445            
Pro Phe Ser Leu Pro Glu Glu Glu Arg Lys Val Val Glu Ala Arg Ala 
    450                  455                460                
Thr Arg Leu Arg Asp Phe Gln Glu Arg Leu Ser Met Lys Asp Gln Leu 
465                  470                475                  480
Ile Ala Gln Ser Leu Leu Glu Lys Gln Gln Ile Tyr Leu Glu Met Ala 
                485                  490                495    
Glu Met Gly Gly Leu Glu Asp Leu Pro Gln Pro Arg Gly Leu Phe Arg 
            500                  505                510        
Gly Gly Asp Pro Ser Glu Thr Leu Gln Gly Glu Leu Ile Leu Lys Ser 
        515                  520                525            
Ala Met Ser Glu Ile Glu Gly Ile Gln Ser Leu Ile Cys Arg Gln Leu 
    530                  535                540                
Gly Ser Ala Asn Gly Gln Ala Glu Asp Gly Gly Ser Ser Thr Gly Pro 
545                  550                555                  560
Pro Arg Arg Ala Glu Thr Phe Ala Gly Tyr Asp Cys Thr Asn Ser Pro 
                565                  570                575    
Thr Lys Asn Gly Ser Phe Lys Lys Lys Val Ser Ser Thr Asp Pro Arg 
            580                  585                590        
Pro Arg Asp Trp Arg Gly Pro Pro Asn Ser Pro Asp Leu Lys Leu Ser 
        595                  600                605            
Asp Ser Asp Ile Pro Gly Ser Ser Glu Glu Ser Pro Gln Val Val Glu 
    610                  615                620                
Ala Pro Gly Thr Glu Ser Asp Pro Arg Leu Pro Thr Val Leu Glu Ser 
625                  630                635                  640
Glu Leu Val Gln Arg Ile Gln Thr Leu Ser Gln Leu Leu Leu Asn Leu 
                645                  650                655    
Gln Ala Val Ile Ala His Gln Asp Ser Tyr Val Glu Thr Gln Arg Ala 
            660                  665                670        
Ala Ile Gln Glu Arg Glu Lys Gln Phe Arg Leu Gln Ser Thr Arg Gly 
        675                  680                685            
Asn Leu Leu Leu Glu Gln Glu Arg Gln Arg Asn Phe Glu Lys Gln Arg 
    690                  695                700                
Glu Glu Arg Ala Ala Leu Glu Lys Leu Gln Ser Gln Leu Arg His Glu 
705                  710                715                  720
Gln Gln Arg Trp Glu Arg Glu Arg Gln Trp Gln His Gln Glu Leu Glu 
                725                  730                735    
Arg Ala Gly Ala Arg Leu Gln Glu Arg Glu Gly Glu Ala Arg Gln Leu 
            740                  745                750        
Arg Glu Arg Leu Glu Gln Glu Arg Ala Glu Leu Glu Arg Gln Arg Gln 
        755                  760                765            
Ala Tyr Gln His Asp Leu Glu Arg Leu Arg Glu Ala Gln Arg Ala Val 
    770                  775                780                
Glu Arg Glu Arg Glu Arg Leu Glu Leu Leu Arg Arg Leu Lys Lys Gln 
785                  790                795                  800
Asn Thr Ala Pro Gly Ala Leu Pro Pro Asp Thr Leu Ala Glu Ala Gln 
                805                  810                815    
Pro Pro Ser His Pro Pro Ser Phe Asn Gly Glu Gly Leu Glu Gly Pro 
            820                  825                830        
Arg Val Ser Met Leu Pro Ser Gly Val Gly Pro Glu Tyr Ala Glu Arg 
        835                  840                845            
Pro Glu Val Ala Arg Arg Asp Ser Ala Pro Thr Glu Asn Arg Leu Ala 
    850                  855                860                
Lys Ser Asp Val Pro Ile Gln Leu Leu Ser Ala Thr Asn Gln Phe Gln 
865                  870                875                  880
Arg Gln Ala Ala Val Gln Gln Gln Ile Pro Thr Lys Leu Ala Ala Ser 
                885                  890                895    
Thr Lys Gly Gly Lys Asp Lys Gly Gly Lys Ser Arg Gly Ser Gln Arg 
            900                  905                910        
Trp Glu Ser Ser Ala Ser Phe Asp Leu Lys Gln Gln Leu Leu Leu Asn 
        915                  920                925            
Lys Leu Met Gly Lys Asp Glu Ser Thr Ser Arg Asn Arg Arg Ser Leu 
    930                  935                940                
Ser Pro Ile Leu Pro Gly Arg His Ser Pro Ala Pro Pro Pro Asp Pro 
945                  950                955                  960
Gly Phe Pro Ala Pro Ser Pro Pro Pro Ala Asp Ser Pro Ser Glu Gly 
                965                  970                975    
Phe Ser Leu Lys Ala Gly Gly Thr Ala Leu Leu Pro Gly Pro Pro Ala 
            980                  985                990        
Pro Ser Pro Leu Pro Ala Arg Trp Arg Arg Gln His Leu Ser Pro Glu 
        995                  1000                1005            
Ser Gly Arg Ile His Phe Pro Asn Arg Ala Pro Arg Arg Phe Thr Met 
    1010                1015                1020                
Asn Leu Arg Val Arg Glu 
1025                1030

<210> 16
<211> 828
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..828
<223> /mol_type="protein"
      /note="Uniprot accession number Q8WUF5"
      /organism="Homo sapiens"

<400> 16
Met Asp Ser Glu Ala Phe Gln Ser Ala Arg Asp Phe Leu Asp Met Asn 
1               5                   10                   15    
Phe Gln Ser Leu Ala Met Lys His Met Asp Leu Lys Gln Met Glu Leu 
            20                   25                  30        
Asp Thr Ala Ala Ala Lys Val Asp Glu Leu Thr Lys Gln Leu Glu Ser 
        35                   40                  45            
Leu Trp Ser Asp Ser Pro Ala Pro Pro Gly Pro Gln Ala Gly Pro Pro 
    50                   55                  60                
Ser Arg Pro Pro Arg Tyr Ser Ser Ser Ser Ile Pro Glu Pro Phe Gly 
65                   70                  75                  80
Ser Arg Gly Ser Pro Arg Lys Ala Ala Thr Asp Gly Ala Asp Thr Pro 
                85                   90                  95    
Phe Gly Arg Ser Glu Ser Ala Pro Thr Leu His Pro Tyr Ser Pro Leu 
            100                  105                110        
Ser Pro Lys Gly Arg Pro Ser Ser Pro Arg Thr Pro Leu Tyr Leu Gln 
        115                  120                125            
Pro Asp Ala Tyr Gly Ser Leu Asp Arg Ala Thr Ser Pro Arg Pro Arg 
    130                  135                140                
Ala Phe Asp Gly Ala Gly Ser Ser Leu Gly Arg Ala Pro Ser Pro Arg 
145                  150                155                  160
Pro Gly Pro Gly Pro Leu Arg Gln Gln Gly Pro Pro Thr Pro Phe Asp 
                165                  170                175    
Phe Leu Gly Arg Ala Gly Ser Pro Arg Gly Ser Pro Leu Ala Glu Gly 
            180                  185                190        
Pro Gln Ala Phe Phe Pro Glu Arg Gly Pro Ser Pro Arg Pro Pro Ala 
        195                  200                205            
Thr Ala Tyr Asp Ala Pro Ala Ser Ala Phe Gly Ser Ser Leu Leu Gly 
    210                  215                220                
Ser Gly Gly Ser Ala Phe Ala Pro Pro Leu Arg Ala Gln Asp Asp Leu 
225                  230                235                  240
Thr Leu Arg Arg Arg Pro Pro Lys Ala Trp Asn Glu Ser Asp Leu Asp 
                245                  250                255    
Val Ala Tyr Glu Lys Lys Pro Ser Gln Thr Ala Ser Tyr Glu Arg Leu 
            260                  265                270        
Asp Val Phe Ala Arg Pro Ala Ser Pro Ser Leu Gln Leu Leu Pro Trp 
        275                  280                285            
Arg Glu Ser Ser Leu Asp Gly Leu Gly Gly Thr Gly Lys Asp Asn Leu 
    290                  295                300                
Thr Ser Ala Thr Leu Pro Arg Asn Tyr Lys Val Ser Pro Leu Ala Ser 
305                  310                315                  320
Asp Arg Arg Ser Asp Ala Gly Ser Tyr Arg Arg Ser Leu Gly Ser Ala 
                325                  330                335    
Gly Pro Ser Gly Thr Leu Pro Arg Ser Trp Gln Pro Val Ser Arg Ile 
            340                  345                350        
Pro Met Pro Pro Ser Ser Pro Gln Pro Arg Gly Ala Pro Arg Gln Arg 
        355                  360                365            
Pro Ile Pro Leu Ser Met Ile Phe Lys Leu Gln Asn Ala Phe Trp Glu 
    370                  375                380                
His Gly Ala Ser Arg Ala Met Leu Pro Gly Ser Pro Leu Phe Thr Arg 
385                  390                395                  400
Ala Pro Pro Pro Lys Leu Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro 
                405                  410                415    
Gln Ser Gln Pro Gln Pro Gln Leu Pro Pro Gln Pro Gln Thr Gln Pro 
            420                  425                430        
Gln Thr Pro Thr Pro Ala Pro Gln His Pro Gln Gln Thr Trp Pro Pro 
        435                  440                445            
Val Asn Glu Gly Pro Pro Lys Pro Pro Thr Glu Leu Glu Pro Glu Pro 
    450                  455                460                
Glu Ile Glu Gly Leu Leu Thr Pro Val Leu Glu Ala Gly Asp Val Asp 
465                  470                475                  480
Glu Gly Pro Val Ala Arg Pro Leu Ser Pro Thr Arg Leu Gln Pro Ala 
                485                  490                495    
Leu Pro Pro Glu Ala Gln Ser Val Pro Glu Leu Glu Glu Val Ala Arg 
            500                  505                510        
Val Leu Ala Glu Ile Pro Arg Pro Leu Lys Arg Arg Gly Ser Met Glu 
        515                  520                525            
Gln Ala Pro Ala Val Ala Leu Pro Pro Thr His Lys Lys Gln Tyr Gln 
    530                  535                540                
Gln Ile Ile Ser Arg Leu Phe His Arg His Gly Gly Pro Gly Pro Gly 
545                  550                555                  560
Gly Pro Glu Pro Glu Leu Ser Pro Ile Thr Glu Gly Ser Glu Ala Arg 
                565                  570                575    
Ala Gly Pro Pro Ala Pro Ala Pro Pro Ala Pro Ile Pro Pro Pro Ala 
            580                  585                590        
Pro Ser Gln Ser Ser Pro Pro Glu Gln Pro Gln Ser Met Glu Met Arg 
        595                  600                605            
Ser Val Leu Arg Lys Ala Gly Ser Pro Arg Lys Ala Arg Arg Ala Arg 
    610                  615                620                
Leu Asn Pro Leu Val Leu Leu Leu Asp Ala Ala Leu Thr Gly Glu Leu 
625                  630                635                  640
Glu Val Val Gln Gln Ala Val Lys Glu Met Asn Asp Pro Ser Gln Pro 
                645                  650                655    
Asn Glu Glu Gly Ile Thr Ala Leu His Asn Ala Ile Cys Gly Ala Asn 
            660                  665                670        
Tyr Ser Ile Val Asp Phe Leu Ile Thr Ala Gly Ala Asn Val Asn Ser 
        675                  680                685            
Pro Asp Ser His Gly Trp Thr Pro Leu His Cys Ala Ala Ser Cys Asn 
    690                  695                700                
Asp Thr Val Ile Cys Met Ala Leu Val Gln His Gly Ala Ala Ile Phe 
705                  710                715                  720
Ala Thr Thr Leu Ser Asp Gly Ala Thr Ala Phe Glu Lys Cys Asp Pro 
                725                  730                735    
Tyr Arg Glu Gly Tyr Ala Asp Cys Ala Thr Tyr Leu Ala Asp Val Glu 
            740                  745                750        
Gln Ser Met Gly Leu Met Asn Ser Gly Ala Val Tyr Ala Leu Trp Asp 
        755                  760                765            
Tyr Ser Ala Glu Phe Gly Asp Glu Leu Ser Phe Arg Glu Gly Glu Ser 
    770                  775                780                
Val Thr Val Leu Arg Arg Asp Gly Pro Glu Glu Thr Asp Trp Trp Trp 
785                  790                795                  800
Ala Ala Leu His Gly Gln Glu Gly Tyr Val Pro Arg Asn Tyr Phe Gly 
                805                  810                815    
Leu Phe Pro Arg Val Lys Pro Gln Arg Ser Lys Val 
            820                  825            

<210> 17
<211> 607
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..607
<223> /mol_type="protein"
      /note="Uniprot accession number Q676U5"
      /organism="Homo sapiens"

<400> 17
Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                   15    
Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                   25                  30        
Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                   40                  45            
His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                   55                  60                
Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                   70                  75                  80
Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                   90                  95    
Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                  105                110        
Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                  120                125            
Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                  135                140                
Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                  150                155                  160
Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                  170                175    
Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                  185                190        
Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                  200                205            
Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                  215                220                
Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                  230                235                  240
Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                  250                255    
Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
            260                  265                270        
Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
        275                  280                285            
Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
    290                  295                300                
Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
305                  310                315                  320
His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu 
                325                  330                335    
Leu Ala Thr Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe 
            340                  345                350        
Gly Glu Lys Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly 
        355                  360                365            
Ile Thr Ser Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala 
    370                  375                380                
Ser Asn Asp Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu 
385                  390                395                  400
Arg His Thr Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe 
                405                  410                415    
Leu Leu Asp Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu 
            420                  425                430        
Lys Leu Trp Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala 
        435                  440                445            
Gly Ser Ser Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser 
    450                  455                460                
Gly His Phe Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser 
465                  470                475                  480
Ile Val Arg Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu 
                485                  490                495    
Asn Pro Glu Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu 
            500                  505                510        
Lys Val Ile Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala 
        515                  520                525            
Pro Gly Phe Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro 
    530                  535                540                
Asp Gly Ser Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile 
545                  550                555                  560
Trp Ser Val Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His 
                565                  570                575    
Ser Ser Ser Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val 
            580                  585                590        
Val Ser Val Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
        595                  600                605        

<210> 18
<211> 470
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..470
<223> /mol_type="protein"
      /note="Uniprot accession number Q676U5-3"
      /organism="Homo sapiens"

<400> 18
Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                   15    
Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                   25                  30        
Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                   40                  45            
His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                   55                  60                
Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                   70                  75                  80
Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                   90                  95    
Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                  105                110        
Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                  120                125            
Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                  135                140                
Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                  150                155                  160
Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                  170                175    
Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                  185                190        
Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                  200                205            
Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                  215                220                
Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                  230                235                  240
Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                  250                255    
Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
            260                  265                270        
Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
        275                  280                285            
Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
    290                  295                300                
Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
305                  310                315                  320
His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu 
                325                  330                335    
Leu Ala Thr Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe 
            340                  345                350        
Gly Glu Lys Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly 
        355                  360                365            
Ile Thr Ser Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala 
    370                  375                380                
Ser Asn Asp Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu 
385                  390                395                  400
Arg His Thr Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe 
                405                  410                415    
Leu Leu Asp Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu 
            420                  425                430        
Lys Leu Trp Asp Leu Arg Ser Lys Val Cys Glu Glu Ile Gln Ser Leu 
        435                  440                445            
Cys Leu Cys Ile Cys Leu Asp Val Ser Val Glu Val Cys Val Cys Thr 
    450                  455                460                
Ser Glu Pro Ala Phe Met 
465                  470

<210> 19
<211> 428
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..428
<223> /mol_type="protein"
      /note="Uniprot accession number Q676U5-4"
      /organism="Homo sapiens"

<400> 19
Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                   15    
Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                   25                  30        
Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                   40                  45            
His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                   55                  60                
Asn Arg His Glu Ile Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
65                   70                  75                  80
Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
                85                   90                  95    
Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
            100                  105                110        
Val Arg Ala Ile Ser Arg Ala Ala Thr Lys Arg Leu Ser Gln Pro Ala 
        115                  120                125            
Gly Gly Leu Leu Asp Ser Ile Thr Asn Ile Phe Gly Arg Arg Ser Val 
    130                  135                140                
Ser Ser Phe Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser 
145                  150                155                  160
Gly Lys Glu Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala 
                165                  170                175    
His Asp Gly Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ile Thr Ser 
            180                  185                190        
Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp 
        195                  200                205            
Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr 
    210                  215                220                
Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp 
225                  230                235                  240
Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp 
                245                  250                255    
Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser 
            260                  265                270        
Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe 
        275                  280                285            
Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg 
    290                  295                300                
Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu 
305                  310                315                  320
Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile 
                325                  330                335    
Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe 
            340                  345                350        
Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser 
        355                  360                365            
Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val 
    370                  375                380                
Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser 
385                  390                395                  400
Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val 
                405                  410                415    
Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
            420                  425            

<210> 20
<211> 206
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..206
<223> /mol_type="protein"
      /note="Uniprot accession number O43399"
      /organism="Homo sapiens"

<400> 20
Met Asp Ser Ala Gly Gln Asp Ile Asn Leu Asn Ser Pro Asn Lys Gly 
1               5                   10                   15    
Leu Leu Ser Asp Ser Met Thr Asp Val Pro Val Asp Thr Gly Val Ala 
            20                   25                  30        
Ala Arg Thr Pro Ala Val Glu Gly Leu Thr Glu Ala Glu Glu Glu Glu 
        35                   40                  45            
Leu Arg Ala Glu Leu Thr Lys Val Glu Glu Glu Ile Val Thr Leu Arg 
    50                   55                  60                
Gln Val Leu Ala Ala Lys Glu Arg His Cys Gly Glu Leu Lys Arg Arg 
65                   70                  75                  80
Leu Gly Leu Ser Thr Leu Gly Glu Leu Lys Gln Asn Leu Ser Arg Ser 
                85                   90                  95    
Trp His Asp Val Gln Val Ser Ser Ala Tyr Val Lys Thr Ser Glu Lys 
            100                  105                110        
Leu Gly Glu Trp Asn Glu Lys Val Thr Gln Ser Asp Leu Tyr Lys Lys 
        115                  120                125            
Thr Gln Glu Thr Leu Ser Gln Ala Gly Gln Lys Thr Ser Ala Ala Leu 
    130                  135                140                
Ser Thr Val Gly Ser Ala Ile Ser Arg Lys Leu Gly Asp Met Arg Asn 
145                  150                155                  160
Ser Ala Thr Phe Lys Ser Phe Glu Asp Arg Val Gly Thr Ile Lys Ser 
                165                  170                175    
Lys Val Val Gly Asp Arg Glu Asn Gly Ser Asp Asn Leu Pro Ser Ser 
            180                  185                190        
Ala Gly Ser Gly Asp Lys Pro Leu Ser Asp Pro Ala Pro Phe 
        195                  200                205    

<210> 21
<211> 186
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..186
<223> /mol_type="protein"
      /note="Uniprot accession number O43399-2"
      /organism="Homo sapiens"

<400> 21
Met Asp Ser Ala Gly Gln Asp Ile Asn Leu Asn Ser Pro Asn Lys Gly 
1               5                   10                   15    
Leu Leu Ser Asp Ser Met Thr Asp Val Pro Val Asp Thr Gly Val Ala 
            20                   25                  30        
Ala Arg Thr Pro Ala Val Glu Gly Leu Thr Glu Ala Glu Glu Glu Glu 
        35                   40                  45            
Leu Arg Ala Glu Leu Thr Lys Val Glu Glu Glu Ile Val Thr Leu Arg 
    50                   55                  60                
Gln Val Leu Ala Ala Lys Glu Arg His Cys Gly Glu Leu Lys Arg Arg 
65                   70                  75                  80
Leu Gly Leu Ser Thr Leu Gly Glu Leu Lys Gln Asn Leu Ser Arg Ser 
                85                   90                  95    
Trp His Asp Val Gln Val Ser Ser Ala Tyr Lys Lys Thr Gln Glu Thr 
            100                  105                110        
Leu Ser Gln Ala Gly Gln Lys Thr Ser Ala Ala Leu Ser Thr Val Gly 
        115                  120                125            
Ser Ala Ile Ser Arg Lys Leu Gly Asp Met Arg Asn Ser Ala Thr Phe 
    130                  135                140                
Lys Ser Phe Glu Asp Arg Val Gly Thr Ile Lys Ser Lys Val Val Gly 
145                  150                155                  160
Asp Arg Glu Asn Gly Ser Asp Asn Leu Pro Ser Ser Ala Gly Ser Gly 
                165                  170                175    
Asp Lys Pro Leu Ser Asp Pro Ala Pro Phe 
            180                  185    

