                         SEQUENCE LISTING

<110>  University of Washington through its Center for 
       Commercialization
       Baker, David
       Siegel, Justin
       Sydney, Gordon
       Wu, Sean
       Toland, Angus
       Hadidi, Daniel
       Wolf, Sarah
       Stanley, Liz
 
<120>  Compositions and Methods for Treating Celiac Sprue Disease

<130>  12-709-PCT

<150>  61/521899
<151>  2011-08-10

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X can be V or D

<220>
<221>  MISC_FEATURE
<222>  (262)..(262)
<223>  X can be S, K or G

<220>
<221>  MISC_FEATURE
<222>  (291)..(291)
<223>  X can be N or D

<220>
<221>  MISC_FEATURE
<222>  (292)..(292)
<223>  X can be T or S

<220>
<221>  MISC_FEATURE
<222>  (293)..(293)
<223>  X can be D, A, T, or N

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  X can be G or S

<220>
<221>  MISC_FEATURE
<222>  (354)..(354)
<223>  X can be S or N

<220>
<221>  MISC_FEATURE
<222>  (357)..(357)
<223>  X can be T or A

<220>
<221>  MISC_FEATURE
<222>  (358)..(358)
<223>  X can be D, N or G

<220>
<221>  MISC_FEATURE
<222>  (361)..(361)
<223>  X can be Q or D

<220>
<221>  MISC_FEATURE
<222>  (368)..(368)
<223>  X can be D, S, or H

<400>  1

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Xaa Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Xaa Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Xaa Xaa Xaa Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Xaa Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Xaa Gly Ser Xaa Xaa Gly Glu Xaa Asp Gly Leu Tyr His Val Xaa 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  2
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X can be V or D

<220>
<221>  MISC_FEATURE
<222>  (262)..(262)
<223>  X can be S, K or G

<220>
<221>  MISC_FEATURE
<222>  (291)..(291)
<223>  All mutants with more than 10-fold activity have this 
       substitution

<220>
<221>  MISC_FEATURE
<222>  (292)..(292)
<223>  X can be T or S

<220>
<221>  MISC_FEATURE
<222>  (293)..(293)
<223>  X can be D, A, T or N

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  X can be G or S

<220>
<221>  MISC_FEATURE
<222>  (354)..(354)
<223>  X can be S or N

<220>
<221>  MISC_FEATURE
<222>  (357)..(357)
<223>  X can be T or A

<220>
<221>  MISC_FEATURE
<222>  (358)..(358)
<223>  X can be D, N or G

<220>
<221>  MISC_FEATURE
<222>  (361)..(361)
<223>  X can be Q or D

<220>
<221>  MISC_FEATURE
<222>  (368)..(368)
<223>  X can be D, S or H

<400>  2

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Xaa Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Xaa Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Xaa Xaa Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Xaa Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Xaa Gly Ser Xaa Xaa Gly Glu Xaa Asp Gly Leu Tyr His Val Xaa 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  3
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X can be V or D

<220>
<221>  MISC_FEATURE
<222>  (262)..(262)
<223>  X can be S, K, or G

<220>
<221>  MISC_FEATURE
<222>  (291)..(291)
<223>  All mutants with more than 20-fold activity increase have this 
       substitution together with 358 substitution

<220>
<221>  MISC_FEATURE
<222>  (292)..(292)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (293)..(293)
<223>  X is D, A, T or N

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  X is G or S

<220>
<221>  MISC_FEATURE
<222>  (354)..(354)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (357)..(357)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (358)..(358)
<223>  X is N or G (most have G at this position)

<220>
<221>  MISC_FEATURE
<222>  (361)..(361)
<223>  X is Q or D

<220>
<221>  MISC_FEATURE
<222>  (368)..(368)
<223>  X is D, S, or H

<400>  3

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Xaa Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Xaa Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Xaa Xaa Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Xaa Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Xaa Gly Ser Xaa Xaa Gly Glu Xaa Asp Gly Leu Tyr His Val Xaa 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  4
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X is V or D

<220>
<221>  MISC_FEATURE
<222>  (262)..(262)
<223>  X is S, K or G

<220>
<221>  MISC_FEATURE
<222>  (291)..(291)
<223>  All mutants with more than 50-fold activity increase have this 
       substitution together with 319, 358, and 368 substitutions

<220>
<221>  MISC_FEATURE
<222>  (292)..(292)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (293)..(293)
<223>  X is D, A, T, or N

<220>
<221>  MISC_FEATURE
<222>  (354)..(354)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (357)..(357)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (361)..(361)
<223>  X is Q or D

<400>  4

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Xaa Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Xaa Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Xaa Xaa Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Xaa Gly Ser Xaa Gly Gly Glu Xaa Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  5
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asn Gly Glu Gln Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  6
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  7
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  8
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Ala Asp Gly Glu Gln Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  9
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  10
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr His Val Ser 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  11
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  12
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asp Gly Glu Asp Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  13
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asn Gly Glu Gln Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  14
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  15
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asn Gly Glu Gln Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  16
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  17
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Asn Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  18
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  19
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  20
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asn Gly Glu Asp Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  21
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Asn Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  22
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  23
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  24
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Asn Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  25
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  26
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Asn Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  27
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Asn Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  28
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Ser Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  29
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Thr Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  30
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Gly Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Ser Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  31
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Lys Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Asn Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  32
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Asp Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Lys Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asp Thr Thr Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Ser Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr His Val His 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  33
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Asp Met Glu Lys Pro Trp Lys Glu Gly Glu Glu Ala Arg Ala 
1               5                   10                  15      


Val Leu Gln Gly His Ala Arg Ala Gln Ala Pro Gln Ala Val Asp Lys 
            20                  25                  30          


Gly Pro Val Ala Gly Asp Glu Arg Met Ala Val Thr Val Val Leu Arg 
        35                  40                  45              


Arg Gln Arg Ala Gly Glu Leu Ala Ala His Val Glu Arg Gln Ala Ala 
    50                  55                  60                  


Ile Ala Pro His Ala Arg Glu His Leu Lys Arg Glu Ala Phe Ala Ala 
65                  70                  75                  80  


Ser His Gly Ala Ser Leu Asp Asp Phe Ala Glu Leu Arg Arg Phe Ala 
                85                  90                  95      


Asp Ala His Gly Leu Ala Leu Asp Arg Ala Asn Val Ala Ala Gly Thr 
            100                 105                 110         


Ala Val Leu Ser Gly Pro Val Asp Ala Ile Asn Arg Ala Phe Gly Val 
        115                 120                 125             


Glu Leu Arg His Phe Asp His Pro Asp Gly Ser Tyr Arg Ser Tyr Leu 
    130                 135                 140                 


Gly Glu Val Thr Val Pro Ala Ser Ile Ala Pro Met Ile Glu Ala Val 
145                 150                 155                 160 


Leu Gly Leu Asp Thr Arg Pro Val Ala Arg Pro His Phe Arg Met Gln 
                165                 170                 175     


Arg Arg Ala Glu Gly Gly Phe Glu Ala Arg Ser Gln Ala Ala Ala Pro 
            180                 185                 190         


Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln Phe Pro Glu 
        195                 200                 205             


Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu Leu Gly Gly 
    210                 215                 220                 


Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser Leu Gly Val 
225                 230                 235                 240 


Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala Ser Asn Gln 
                245                 250                 255     


Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu Leu Asp Ile 
            260                 265                 270         


Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala Val Tyr Phe 
        275                 280                 285             


Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr Thr Ala Ile 
    290                 295                 300                 


His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser Trp Gly Gly 
305                 310                 315                 320 


Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met Asn Arg Ala 
                325                 330                 335     


Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala Ala Ala Gly 
            340                 345                 350         


Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr His Val Asp 
        355                 360                 365             


Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly Thr Arg Leu 
    370                 375                 380                 


Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp Asn Asp Gly 
385                 390                 395                 400 


Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile Phe Pro Leu 
                405                 410                 415     


Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala Asn Pro Gly 
            420                 425                 430         


Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn Ala Asp Pro 
        435                 440                 445             


Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr Val Ile Gly 
    450                 455                 460                 


Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val Ala Arg Ile 
465                 470                 475                 480 


Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro Thr Leu Tyr 
                485                 490                 495     


Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly Asn Asn Asp 
            500                 505                 510         


Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly Trp Asp Pro 
        515                 520                 525             


Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu Gln Ala Leu 
    530                 535                 540                 


Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu Asn Leu Tyr 
545                 550                 555                 560 


Phe Gln Ser Gly Ala Leu Glu His His His His His His 
                565                 570             


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Pro Gln Pro Gln Leu Pro 
1               5       


<210>  35
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X can be S, K or G

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  X can be N or D

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  X can be T or S

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  X can be T or S

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  X can be G or S

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  X can be S or N

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  X can be T or A

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  X can be D, N or G

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  X can be Q or D

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  X can be D, S, or H

<400>  35

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Xaa Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Xaa Xaa Xaa Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Xaa Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Xaa Gly Ser Xaa Xaa Gly Glu Xaa Asp Gly Leu Tyr 
                165                 170                 175     


His Val Xaa Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  36
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X can be S, K or G

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  All mutants with more than 10-fold activity have this 
       substitution

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  X can be T or S

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  X can be D, A, T or N

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  X can be G or S

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  X can be S or N

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  X can be T or A

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  X can be D, N, or G

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  X can be Q or D

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  X can be D, S, or H

<400>  36

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Xaa Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Xaa Xaa Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Xaa Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Xaa Gly Ser Xaa Xaa Gly Glu Xaa Asp Gly Leu Tyr 
                165                 170                 175     


His Val Xaa Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  37
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X is S, K, or G

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  All mutants with more than 20-fold activity increase have this 
       substitution together with 358 substitution

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  X is D, A, T or N

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  X is G or S

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  X is N or G (most have G at this position)

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  X is Q or D

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  X is D, S, or H

<400>  37

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Xaa Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Xaa Xaa Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Xaa Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Xaa Gly Ser Xaa Xaa Gly Glu Xaa Asp Gly Leu Tyr 
                165                 170                 175     


His Val Xaa Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  38
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X is S, K, or G

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  All mutants with more than 50-fold activity increase have this 
       substitution together with 319, 358, and 368 substitutions

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  X is D, A, T, or N

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  X is Q or D

<400>  38

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Xaa Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Xaa Xaa Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Xaa Gly Ser Xaa Gly Gly Glu Xaa Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  39
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asn Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  40
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  41
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  42
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Ala Asp Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  43
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  44
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Ser Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  45
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  46
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asp Gly Glu Asp Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  47
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asn Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  48
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  49
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asn Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  50
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  51
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Asn Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  52
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  53
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  54
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asn Gly Glu Asp Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  55
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Asn Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  56
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  57
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  58
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Asn Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  59
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  60
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Asn Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  61
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Ala Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Asn Gly Ser Thr Gly Gly Glu Asp Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  62
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Ser Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  63
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Thr Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  64
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Gly Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Ser Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  65
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Lys Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Asn Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  66
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Lys Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asp Thr Thr Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Ser Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Gly Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val His Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  67
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  67

Ala Ala Pro Thr Ala Tyr Thr Pro Leu Asp Val Ala Gln Ala Tyr Gln 
1               5                   10                  15      


Phe Pro Glu Gly Leu Asp Gly Gln Gly Gln Cys Ile Ala Ile Ile Glu 
            20                  25                  30          


Leu Gly Gly Gly Tyr Asp Glu Ala Ser Leu Ala Gln Tyr Phe Ala Ser 
        35                  40                  45              


Leu Gly Val Pro Ala Pro Gln Val Val Ser Val Ser Val Asp Gly Ala 
    50                  55                  60                  


Ser Asn Gln Pro Thr Gly Asp Pro Ser Gly Pro Asp Gly Glu Val Glu 
65                  70                  75                  80  


Leu Asp Ile Glu Val Ala Gly Ala Leu Ala Pro Gly Ala Lys Phe Ala 
                85                  90                  95      


Val Tyr Phe Ala Pro Asn Thr Asp Ala Gly Phe Leu Asp Ala Ile Thr 
            100                 105                 110         


Thr Ala Ile His Asp Pro Thr Leu Lys Pro Ser Val Val Ser Ile Ser 
        115                 120                 125             


Trp Gly Gly Pro Glu Asp Ser Trp Thr Ser Ala Ala Ile Ala Ala Met 
    130                 135                 140                 


Asn Arg Ala Phe Leu Asp Ala Ala Ala Leu Gly Val Thr Val Leu Ala 
145                 150                 155                 160 


Ala Ala Gly Asp Ser Gly Ser Thr Asp Gly Glu Gln Asp Gly Leu Tyr 
                165                 170                 175     


His Val Asp Phe Pro Ala Ala Ser Pro Tyr Val Leu Ala Cys Gly Gly 
            180                 185                 190         


Thr Arg Leu Val Ala Ser Gly Gly Arg Ile Ala Gln Glu Thr Val Trp 
        195                 200                 205             


Asn Asp Gly Pro Asp Gly Gly Ala Thr Gly Gly Gly Val Ser Arg Ile 
    210                 215                 220                 


Phe Pro Leu Pro Ala Trp Gln Glu His Ala Asn Val Pro Pro Ser Ala 
225                 230                 235                 240 


Asn Pro Gly Ala Ser Ser Gly Arg Gly Val Pro Asp Leu Ala Gly Asn 
                245                 250                 255     


Ala Asp Pro Ala Thr Gly Tyr Glu Val Val Ile Asp Gly Glu Ala Thr 
            260                 265                 270         


Val Ile Gly Gly Thr Ser Ala Val Ala Pro Leu Phe Ala Ala Leu Val 
        275                 280                 285             


Ala Arg Ile Asn Gln Lys Leu Gly Lys Ala Val Gly Tyr Leu Asn Pro 
    290                 295                 300                 


Thr Leu Tyr Gln Leu Pro Ala Asp Val Phe His Asp Ile Thr Glu Gly 
305                 310                 315                 320 


Asn Asn Asp Ile Ala Asn Arg Ala Gln Ile Tyr Gln Ala Gly Pro Gly 
                325                 330                 335     


Trp Asp Pro Cys Thr Gly Leu Gly Ser Pro Ile Gly Val Arg Leu Leu 
            340                 345                 350         


Gln Ala Leu Leu Pro Ser Ala Ser Gln Pro Gln Pro Gly Ser Thr Glu 
        355                 360                 365             


Asn Leu Tyr Phe Gln Ser Gly Ala Leu Glu His His His His His His 
    370                 375                 380                 


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Pro Gln Leu Pro 
1               


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal QXL520

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  C-terminal K(5-FAM)

<400>  69

Pro Gln Pro Gln Leu Pro 
1               5       


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr 
1               5                   10          


<210>  71
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Val Arg Val Pro Val Pro Gln Leu Gln Pro Gln Asn Pro Ser Gln 
1               5                   10                  15      


Gln Gln Pro Gln Glu Gln Val Pro Leu Val Gln Gln Gln Gln Phe Pro 
            20                  25                  30          


Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro Gln Pro Gln 
        35                  40                  45              


Pro Phe Pro Ser Gln Gln Phe Tyr Leu Gln Leu Gln Pro Phe Pro Gln 
    50                  55                  60                  


Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln 
65                  70                  75                  80  


Leu Pro Tyr Pro Gln Pro Gln Pro Phe Arg Pro Gln Gln Pro Tyr Pro 
                85                  90                  95      


Gln Ser Gln Pro Gln Tyr Ser Gln Pro Gln Gln Pro Ile Ser Gln Gln 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln Ile Leu Gln Gln Ile Leu Gln Gln Gln Leu Ile Pro Cys 
    130                 135                 140                 


Arg Asp Val Val Leu Gln Gln His Ser Ile Ala Tyr Gly Ser Ser Gln 
145                 150                 155                 160 


Val Leu Gln Gln Ser Thr Tyr Gly Leu Val Gln Gln Leu Cys Cys Gln 
                165                 170                 175     


Gln Leu Trp Gln Ile Pro Glu Gln Ser Arg Cys Gln Ala Ile His Asn 
            180                 185                 190         


Val Val His Ala Ile Ile Leu His Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


Gln Gln Gln Gln Pro Leu Ser Gln Val Ser Phe Gln Gln Pro Gln Gln 
    210                 215                 220                 


Gln Tyr Pro Ser Gly Gln Gly Ser Phe Gln Pro Ser Gln Gln Asn Pro 
225                 230                 235                 240 


Gln Ala Gln Gly Ser Val Gln Pro Gln Gln Leu Pro Gln Phe Glu Glu 
                245                 250                 255     


Ile Arg Asn Leu Ala Leu Glu Thr Leu Pro Ala Met Cys Asn Val Tyr 
            260                 265                 270         


Ile Pro Pro Tyr Cys Thr Ile Ala Pro Val Gly Ile Phe Gly Thr Asn 
        275                 280                 285             


Tyr Arg 
    290 


<210>  72
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro 
1               5                   10                  15      


Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Pro 
            20                  25                  30          


Phe 
    


<210>  73
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Phe Leu Gln Pro Gln Gln Pro Phe Pro Pro Gln Gln Pro Gln Gln Pro 
1               5                   10                  15      


Tyr Pro Gln Gln Pro Gln Gln Pro Phe Pro 
            20                  25      


