
                                SEQUENCE LISTING

<110> Metabolix, Inc.
      van Walsem, Johan
      Anderson, Erik
      Licata, John
      Sparks, Kevin A.
      Farmer, William R.
      Mirley, Christopher
      Bickmeier, Jeffrey A.
      D'Ambruoso, Ann
      Skraly, Frank A.
      Ramseier, Thomas M.
      Sivasubramanian, M. S.
      Samuelson, Derek
      Shabtai, Yossef
      Harris, Stephen

<120> Post Process Purification For
  Gamma-Butyrolactone Production

<130> 4614.1005002

<150> 61/522,182          
<151> 2011-08-10  

<150> 61/610,795          
<151> 2012-03-14  

<160> 12

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2901
<212> DNA
<213> Artificial Sequence

<220> 
<223> Medicago sativa

<400> 1
atggcaaaca aaatggaaaa gatggcaagc attgacgcgc aactgcgcca gttggtcccg 60
gcaaaagtca gcgaggacga caaattgatt gaatacgatg ctctgttgct ggaccgcttt 120
ctggacattc tgcaagatct gcatggcgag gatctgaagg attcggttca ggaagtttac 180
gaactgtctg cggagtatga gcgtaagcat gacccgaaga agctggaaga gctgggtaac 240
ttgattacga gctttgacgc gggcgacagc attgtcgtgg cgaaatcgtt ctctcatatg 300
ctgaatctgg cgaacctggc cgaagaagtt caaattgctc accgccgtcg taacaagctg 360
aagaagggtg attttcgtga tgagagcaat gcgaccaccg agtccgatat tgaggagact 420
ctgaagaaac tggttttcga catgaagaag tctccgcaag aagtgtttga cgcgttgaag 480
aatcagaccg tggacctggt gctgacggca catcctaccc agagcgttcg ccgttccctg 540
ctgcaaaagc atggtcgtgt tcgtaattgc ttgagccagc tgtatgcgaa agacattacc 600
ccggatgaca aacaagagct ggacgaggca ctgcagcgtg aaatccaggc agcgttccgt 660
accgatgaaa tcaaacgtac cccgccgacc ccacaagacg aaatgcgtgc tggcatgagc 720
tatttccacg aaaccatctg gaagggcgtc ccgaagttcc tgcgtcgcgt ggacaccgcg 780
ttgaagaaca tcggcattaa cgaacgcgtg ccgtataacg ccccgctgat tcaattcagc 840
agctggatgg gtggcgaccg tgacggcaat ccgcgtgtta cgccagaagt gacccgtgat 900
gtttgtctgc tggcgcgtat gatggcggcg aatttgtact atagccagat tgaagatctg 960
atgtttgagc tgtctatgtg gcgctgtaat gatgagttgc gtgtgcgtgc cgaagaactg 1020
caccgcaata gcaagaaaga cgaagttgcc aagcactaca tcgagttctg gaagaagatc 1080
ccgttgaacg agccgtaccg tgttgttctg ggtgaggtcc gcgataagct gtatcgcacc 1140
cgtgagcgca gccgttatct gctggcacac ggttattgcg aaattccgga ggaggcgacc 1200
tttaccaacg tggatgaatt tctggaaccg ctggagctgt gttatcgtag cctgtgcgcg 1260
tgcggtgacc gcgcgattgc ggacggttct ttgctggatt tcctgcgcca ggtgagcacg 1320
tttggtctga gcctggtccg tctggatatc cgtcaggaat cggaccgcca tacggatgtg 1380
atggacgcta ttaccaaaca cctggaaatt ggcagctacc aggagtggag cgaggagaaa 1440
cgtcaagagt ggctgctgag cgagctgatc ggtaagcgtc cgctgttcgg tccagatctg 1500
ccgcaaaccg acgaaatccg cgacgttctg gacacctttc gtgtgattgc cgaactgccg 1560
agcgacaact tcggcgcgta cattatctcc atggccaccg ccccgagcga tgtcctggca 1620
gtcgagctgc tgcaacgcga atgtaaggtc cgtaacccgt tgcgcgtggt tccgctgttt 1680
gaaaagctgg atgacctgga gagcgcaccg gccgcactgg ctcgtctgtt tagcattgac 1740
tggtacatta accgtattga tggtaaacag gaagtgatga ttggttactc cgacagcggt 1800
aaagatgcgg gtcgttttag cgccgcatgg cagctgtaca aggcacaaga agatctgatc 1860
aaggttgcac agaagttcgg cgttaaactg accatgttcc acggtcgcgg tggtacggtt 1920
ggccgtggtg gcggcccaac ccacctggcg attctgagcc aaccgccgga gactatccat 1980
ggttccttgc gtgtcaccgt ccagggcgaa gtgattgagc aaagcttcgg cgaggaacat 2040
ctgtgctttc gcaccctgca gcgttttacg gccgcgactt tggaacacgg catgcgtccg 2100
ccatccagcc caaagccaga atggcgtgcg ctgatggacc aaatggcggt tatcgcgacc 2160
gaggagtatc gcagcattgt gttcaaagag ccgcgttttg tggagtattt ccgtttggca 2220
acgccggaga tggagtacgg ccgcatgaat atcggcagcc gtccggcaaa acgtcgcccg 2280
tccggcggca tcgagacgct gcgtgccatc ccgtggattt tcgcgtggac gcagacccgt 2340
ttccatttgc cggtgtggct gggtttcggt gccgcctttc gtcaagtcgt gcagaaggac 2400
gtgaagaatc tgcatatgct gcaggagatg tacaaccagt ggccgttctt tcgtgtcacc 2460
attgatctgg tggaaatggt ctttgcgaaa ggtgatccgg gcatcgcggc gttgaatgac 2520
cgtctgctgg tttccaaaga cctgtggcct tttggtgaac agctgcgtag caagtacgag 2580
gaaaccaaga aactgctgtt gcaagttgcg gcgcacaagg aggtgctgga aggtgaccct 2640
tatctgaagc aacgcctgcg tctgcgtgac tcgtacatca cgaccctgaa tgtctttcag 2700
gcgtataccc tgaagcgtat ccgtgacccg aattacaaag tggaagttcg ccctccgatc 2760
agcaaggaga gcgcggagac tagcaaacca gcggacgaac tggtcaccct gaatccgacc 2820
tcggagtatg ctccgggttt ggaagatacg ctgattctga cgatgaaggg tatcgcggct 2880
ggcatgcaga acacgggcta a                                           2901

<210> 2
<211> 966
<212> PRT
<213> Artificial Sequence

<220> 
<223> Medicago sativa

<400> 2
Met Ala Asn Lys Met Glu Lys Met Ala Ser Ile Asp Ala Gln Leu Arg
 1               5                  10                  15      
Gln Leu Val Pro Ala Lys Val Ser Glu Asp Asp Lys Leu Ile Glu Tyr
            20                  25                  30          
Asp Ala Leu Leu Leu Asp Arg Phe Leu Asp Ile Leu Gln Asp Leu His
        35                  40                  45              
Gly Glu Asp Leu Lys Asp Ser Val Gln Glu Val Tyr Glu Leu Ser Ala
    50                  55                  60                  
Glu Tyr Glu Arg Lys His Asp Pro Lys Lys Leu Glu Glu Leu Gly Asn
65                  70                  75                  80  
Leu Ile Thr Ser Phe Asp Ala Gly Asp Ser Ile Val Val Ala Lys Ser
                85                  90                  95      
Phe Ser His Met Leu Asn Leu Ala Asn Leu Ala Glu Glu Val Gln Ile
            100                 105                 110         
Ala His Arg Arg Arg Asn Lys Leu Lys Lys Gly Asp Phe Arg Asp Glu
        115                 120                 125             
Ser Asn Ala Thr Thr Glu Ser Asp Ile Glu Glu Thr Leu Lys Lys Leu
    130                 135                 140                 
Val Phe Asp Met Lys Lys Ser Pro Gln Glu Val Phe Asp Ala Leu Lys
145                 150                 155                 160 
Asn Gln Thr Val Asp Leu Val Leu Thr Ala His Pro Thr Gln Ser Val
                165                 170                 175     
Arg Arg Ser Leu Leu Gln Lys His Gly Arg Val Arg Asn Cys Leu Ser
            180                 185                 190         
Gln Leu Tyr Ala Lys Asp Ile Thr Pro Asp Asp Lys Gln Glu Leu Asp
        195                 200                 205             
Glu Ala Leu Gln Arg Glu Ile Gln Ala Ala Phe Arg Thr Asp Glu Ile
    210                 215                 220                 
Lys Arg Thr Pro Pro Thr Pro Gln Asp Glu Met Arg Ala Gly Met Ser
225                 230                 235                 240 
Tyr Phe His Glu Thr Ile Trp Lys Gly Val Pro Lys Phe Leu Arg Arg
                245                 250                 255     
Val Asp Thr Ala Leu Lys Asn Ile Gly Ile Asn Glu Arg Val Pro Tyr
            260                 265                 270         
Asn Ala Pro Leu Ile Gln Phe Ser Ser Trp Met Gly Gly Asp Arg Asp
        275                 280                 285             
Gly Asn Pro Arg Val Thr Pro Glu Val Thr Arg Asp Val Cys Leu Leu
    290                 295                 300                 
Ala Arg Met Met Ala Ala Asn Leu Tyr Tyr Ser Gln Ile Glu Asp Leu
305                 310                 315                 320 
Met Phe Glu Leu Ser Met Trp Arg Cys Asn Asp Glu Leu Arg Val Arg
                325                 330                 335     
Ala Glu Glu Leu His Arg Asn Ser Lys Lys Asp Glu Val Ala Lys His
            340                 345                 350         
Tyr Ile Glu Phe Trp Lys Lys Ile Pro Leu Asn Glu Pro Tyr Arg Val
        355                 360                 365             
Val Leu Gly Glu Val Arg Asp Lys Leu Tyr Arg Thr Arg Glu Arg Ser
    370                 375                 380                 
Arg Tyr Leu Leu Ala His Gly Tyr Cys Glu Ile Pro Glu Glu Ala Thr
385                 390                 395                 400 
Phe Thr Asn Val Asp Glu Phe Leu Glu Pro Leu Glu Leu Cys Tyr Arg
                405                 410                 415     
Ser Leu Cys Ala Cys Gly Asp Arg Ala Ile Ala Asp Gly Ser Leu Leu
            420                 425                 430         
Asp Phe Leu Arg Gln Val Ser Thr Phe Gly Leu Ser Leu Val Arg Leu
        435                 440                 445             
Asp Ile Arg Gln Glu Ser Asp Arg His Thr Asp Val Met Asp Ala Ile
    450                 455                 460                 
Thr Lys His Leu Glu Ile Gly Ser Tyr Gln Glu Trp Ser Glu Glu Lys
465                 470                 475                 480 
Arg Gln Glu Trp Leu Leu Ser Glu Leu Ile Gly Lys Arg Pro Leu Phe
                485                 490                 495     
Gly Pro Asp Leu Pro Gln Thr Asp Glu Ile Arg Asp Val Leu Asp Thr
            500                 505                 510         
Phe Arg Val Ile Ala Glu Leu Pro Ser Asp Asn Phe Gly Ala Tyr Ile
        515                 520                 525             
Ile Ser Met Ala Thr Ala Pro Ser Asp Val Leu Ala Val Glu Leu Leu
    530                 535                 540                 
Gln Arg Glu Cys Lys Val Arg Asn Pro Leu Arg Val Val Pro Leu Phe
545                 550                 555                 560 
Glu Lys Leu Asp Asp Leu Glu Ser Ala Pro Ala Ala Leu Ala Arg Leu
                565                 570                 575     
Phe Ser Ile Asp Trp Tyr Ile Asn Arg Ile Asp Gly Lys Gln Glu Val
            580                 585                 590         
Met Ile Gly Tyr Ser Asp Ser Gly Lys Asp Ala Gly Arg Phe Ser Ala
        595                 600                 605             
Ala Trp Gln Leu Tyr Lys Ala Gln Glu Asp Leu Ile Lys Val Ala Gln
    610                 615                 620                 
Lys Phe Gly Val Lys Leu Thr Met Phe His Gly Arg Gly Gly Thr Val
625                 630                 635                 640 
Gly Arg Gly Gly Gly Pro Thr His Leu Ala Ile Leu Ser Gln Pro Pro
                645                 650                 655     
Glu Thr Ile His Gly Ser Leu Arg Val Thr Val Gln Gly Glu Val Ile
            660                 665                 670         
Glu Gln Ser Phe Gly Glu Glu His Leu Cys Phe Arg Thr Leu Gln Arg
        675                 680                 685             
Phe Thr Ala Ala Thr Leu Glu His Gly Met Arg Pro Pro Ser Ser Pro
    690                 695                 700                 
Lys Pro Glu Trp Arg Ala Leu Met Asp Gln Met Ala Val Ile Ala Thr
705                 710                 715                 720 
Glu Glu Tyr Arg Ser Ile Val Phe Lys Glu Pro Arg Phe Val Glu Tyr
                725                 730                 735     
Phe Arg Leu Ala Thr Pro Glu Met Glu Tyr Gly Arg Met Asn Ile Gly
            740                 745                 750         
Ser Arg Pro Ala Lys Arg Arg Pro Ser Gly Gly Ile Glu Thr Leu Arg
        755                 760                 765             
Ala Ile Pro Trp Ile Phe Ala Trp Thr Gln Thr Arg Phe His Leu Pro
    770                 775                 780                 
Val Trp Leu Gly Phe Gly Ala Ala Phe Arg Gln Val Val Gln Lys Asp
785                 790                 795                 800 
Val Lys Asn Leu His Met Leu Gln Glu Met Tyr Asn Gln Trp Pro Phe
                805                 810                 815     
Phe Arg Val Thr Ile Asp Leu Val Glu Met Val Phe Ala Lys Gly Asp
            820                 825                 830         
Pro Gly Ile Ala Ala Leu Asn Asp Arg Leu Leu Val Ser Lys Asp Leu
        835                 840                 845             
Trp Pro Phe Gly Glu Gln Leu Arg Ser Lys Tyr Glu Glu Thr Lys Lys
    850                 855                 860                 
Leu Leu Leu Gln Val Ala Ala His Lys Glu Val Leu Glu Gly Asp Pro
865                 870                 875                 880 
Tyr Leu Lys Gln Arg Leu Arg Leu Arg Asp Ser Tyr Ile Thr Thr Leu
                885                 890                 895     
Asn Val Phe Gln Ala Tyr Thr Leu Lys Arg Ile Arg Asp Pro Asn Tyr
            900                 905                 910         
Lys Val Glu Val Arg Pro Pro Ile Ser Lys Glu Ser Ala Glu Thr Ser
        915                 920                 925             
Lys Pro Ala Asp Glu Leu Val Thr Leu Asn Pro Thr Ser Glu Tyr Ala
    930                 935                 940                 
Pro Gly Leu Glu Asp Thr Leu Ile Leu Thr Met Lys Gly Ile Ala Ala
945                 950                 955                 960 
Gly Met Gln Asn Thr Gly
                965     


<210> 3
<211> 1362
<212> DNA
<213> Artificial Sequence

<220> 
<223> Clostridium kluyveri

<400> 3
atgtccaacg aggttagcat taaggagctg attgagaagg cgaaagtggc gcagaaaaag 60
ctggaagcgt atagccaaga gcaagttgac gttctggtca aggcgctggg taaagttgtg 120
tacgacaacg ccgagatgtt cgcgaaagag gcggtggagg aaaccgagat gggtgtttac 180
gaggataaag tggctaaatg tcatctgaaa tctggtgcaa tctggaatca cattaaagat 240
aagaaaaccg ttggtattat caaggaagaa ccggagcgtg cgctggtgta cgtcgcgaag 300
cctaaaggtg ttgtggcggc gacgacccct atcaccaatc ctgtggttac cccgatgtgt 360
aacgcgatgg cagcaattaa aggtcgcaac accatcattg tcgccccgca tccgaaggcg 420
aagaaggtga gcgcgcacac cgtggagctg atgaatgcag aactgaaaaa gttgggtgcg 480
ccggaaaaca ttatccagat cgttgaagcc ccaagccgtg aagcagccaa ggagttgatg 540
gagagcgcag acgtggttat cgccacgggt ggcgcaggcc gtgttaaagc agcgtactcc 600
tccggccgtc cggcatacgg tgtcggtccg ggcaattctc aggtcattgt cgataagggt 660
tacgattata acaaagctgc ccaggacatc attaccggcc gcaagtatga caacggtatc 720
atttgcagct ctgagcagag cgtgatcgca ccggcggagg actacgacaa ggtcatcgcg 780
gctttcgtcg agaatggcgc gttctatgtc gaggatgagg aaactgtgga gaaattccgt 840
agcacgctgt tcaaggatgg caagatcaat agcaaaatca tcggtaaatc cgtgcagatc 900
atcgctgacc tggctggtgt caaggtgccg gaaggcacca aggtgatcgt gttgaagggc 960
aagggtgccg gtgaaaagga cgttctgtgc aaggagaaaa tgtgcccggt cctggttgcc 1020
ctgaaatatg acacctttga ggaggcggtc gagatcgcga tggccaacta tatgtacgag 1080
ggtgcgggcc ataccgccgg tatccacagc gataacgacg agaatatccg ctacgcgggt 1140
acggtgctgc caatcagccg tctggttgtc aaccagccag caactacggc cggtggtagc 1200
tttaacaatg gttttaatcc gaccaccacc ttgggctgcg gtagctgggg ccgtaactcc 1260
attagcgaga acctgacgta tgagcatctg attaatgtca gccgtattgg ctatttcaat 1320
aaggaggcaa aagttcctag ctacgaggag atctggggtt aa                    1362

<210> 4
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> Clostridium kluyveri

<400> 4
Met Ser Asn Glu Val Ser Ile Lys Glu Leu Ile Glu Lys Ala Lys Val
 1               5                  10                  15      
Ala Gln Lys Lys Leu Glu Ala Tyr Ser Gln Glu Gln Val Asp Val Leu
            20                  25                  30          
Val Lys Ala Leu Gly Lys Val Val Tyr Asp Asn Ala Glu Met Phe Ala
        35                  40                  45              
Lys Glu Ala Val Glu Glu Thr Glu Met Gly Val Tyr Glu Asp Lys Val
    50                  55                  60                  
Ala Lys Cys His Leu Lys Ser Gly Ala Ile Trp Asn His Ile Lys Asp
65                  70                  75                  80  
Lys Lys Thr Val Gly Ile Ile Lys Glu Glu Pro Glu Arg Ala Leu Val
                85                  90                  95      
Tyr Val Ala Lys Pro Lys Gly Val Val Ala Ala Thr Thr Pro Ile Thr
            100                 105                 110         
Asn Pro Val Val Thr Pro Met Cys Asn Ala Met Ala Ala Ile Lys Gly
        115                 120                 125             
Arg Asn Thr Ile Ile Val Ala Pro His Pro Lys Ala Lys Lys Val Ser
    130                 135                 140                 
Ala His Thr Val Glu Leu Met Asn Ala Glu Leu Lys Lys Leu Gly Ala
145                 150                 155                 160 
Pro Glu Asn Ile Ile Gln Ile Val Glu Ala Pro Ser Arg Glu Ala Ala
                165                 170                 175     
Lys Glu Leu Met Glu Ser Ala Asp Val Val Ile Ala Thr Gly Gly Ala
            180                 185                 190         
Gly Arg Val Lys Ala Ala Tyr Ser Ser Gly Arg Pro Ala Tyr Gly Val
        195                 200                 205             
Gly Pro Gly Asn Ser Gln Val Ile Val Asp Lys Gly Tyr Asp Tyr Asn
    210                 215                 220                 
Lys Ala Ala Gln Asp Ile Ile Thr Gly Arg Lys Tyr Asp Asn Gly Ile
225                 230                 235                 240 
Ile Cys Ser Ser Glu Gln Ser Val Ile Ala Pro Ala Glu Asp Tyr Asp
                245                 250                 255     
Lys Val Ile Ala Ala Phe Val Glu Asn Gly Ala Phe Tyr Val Glu Asp
            260                 265                 270         
Glu Glu Thr Val Glu Lys Phe Arg Ser Thr Leu Phe Lys Asp Gly Lys
        275                 280                 285             
Ile Asn Ser Lys Ile Ile Gly Lys Ser Val Gln Ile Ile Ala Asp Leu
    290                 295                 300                 
Ala Gly Val Lys Val Pro Glu Gly Thr Lys Val Ile Val Leu Lys Gly
305                 310                 315                 320 
Lys Gly Ala Gly Glu Lys Asp Val Leu Cys Lys Glu Lys Met Cys Pro
                325                 330                 335     
Val Leu Val Ala Leu Lys Tyr Asp Thr Phe Glu Glu Ala Val Glu Ile
            340                 345                 350         
Ala Met Ala Asn Tyr Met Tyr Glu Gly Ala Gly His Thr Ala Gly Ile
        355                 360                 365             
His Ser Asp Asn Asp Glu Asn Ile Arg Tyr Ala Gly Thr Val Leu Pro
    370                 375                 380                 
Ile Ser Arg Leu Val Val Asn Gln Pro Ala Thr Thr Ala Gly Gly Ser
385                 390                 395                 400 
Phe Asn Asn Gly Phe Asn Pro Thr Thr Thr Leu Gly Cys Gly Ser Trp
                405                 410                 415     
Gly Arg Asn Ser Ile Ser Glu Asn Leu Thr Tyr Glu His Leu Ile Asn
            420                 425                 430         
Val Ser Arg Ile Gly Tyr Phe Asn Lys Glu Ala Lys Val Pro Ser Tyr
        435                 440                 445             
Glu Glu Ile Trp Gly
    450             


<210> 5
<211> 870
<212> DNA
<213> Artificial Sequence

<220> 
<223> Arabidopsis thaliana

<400> 5
atggaagtag gttttctggg tctgggcatt atgggtaaag ctatgtccat gaacctgctg 60
aaaaacggtt tcaaagttac cgtgtggaac cgcactctgt ctaaatgtga tgaactggtt 120
gaacacggtg caagcgtgtg cgagtctccg gctgaggtga tcaagaaatg caaatacacg 180
atcgcgatgc tgagcgatcc gtgtgcagct ctgtctgttg ttttcgataa aggcggtgtt 240
ctggaacaga tctgcgaggg taagggctac atcgacatgt ctaccgtcga cgcggaaact 300
agcctgaaaa ttaacgaagc gatcacgggc aaaggtggcc gttttgtaga aggtcctgtt 360
agcggttcca aaaagccggc agaagacggc cagctgatca tcctggcagc aggcgacaaa 420
gcactgttcg aggaatccat cccggccttt gatgtactgg gcaaacgttc cttttatctg 480
ggtcaggtgg gtaacggtgc gaaaatgaaa ctgattgtta acatgatcat gggttctatg 540
atgaacgcgt ttagcgaagg tctggtactg gcagataaaa gcggtctgtc tagcgacacg 600
ctgctggata ttctggatct gggtgctatg acgaatccga tgttcaaagg caaaggtccg 660
tccatgacta aatccagcta cccaccggct ttcccgctga aacaccagca gaaagacatg 720
cgtctggctc tggctctggg cgacgaaaac gctgttagca tgccggtcgc tgcggctgcg 780
aacgaagcct tcaagaaagc ccgtagcctg ggcctgggcg atctggactt ttctgctgtt 840
atcgaagcgg taaaattctc tcgtgaataa                                  870

<210> 6
<211> 289
<212> PRT
<213> Artificial Sequence

<220> 
<223> Arabidopsis thaliana

<400> 6
Met Glu Val Gly Phe Leu Gly Leu Gly Ile Met Gly Lys Ala Met Ser
 1               5                  10                  15      
Met Asn Leu Leu Lys Asn Gly Phe Lys Val Thr Val Trp Asn Arg Thr
            20                  25                  30          
Leu Ser Lys Cys Asp Glu Leu Val Glu His Gly Ala Ser Val Cys Glu
        35                  40                  45              
Ser Pro Ala Glu Val Ile Lys Lys Cys Lys Tyr Thr Ile Ala Met Leu
    50                  55                  60                  
Ser Asp Pro Cys Ala Ala Leu Ser Val Val Phe Asp Lys Gly Gly Val
65                  70                  75                  80  
Leu Glu Gln Ile Cys Glu Gly Lys Gly Tyr Ile Asp Met Ser Thr Val
                85                  90                  95      
Asp Ala Glu Thr Ser Leu Lys Ile Asn Glu Ala Ile Thr Gly Lys Gly
            100                 105                 110         
Gly Arg Phe Val Glu Gly Pro Val Ser Gly Ser Lys Lys Pro Ala Glu
        115                 120                 125             
Asp Gly Gln Leu Ile Ile Leu Ala Ala Gly Asp Lys Ala Leu Phe Glu
    130                 135                 140                 
Glu Ser Ile Pro Ala Phe Asp Val Leu Gly Lys Arg Ser Phe Tyr Leu
145                 150                 155                 160 
Gly Gln Val Gly Asn Gly Ala Lys Met Lys Leu Ile Val Asn Met Ile
                165                 170                 175     
Met Gly Ser Met Met Asn Ala Phe Ser Glu Gly Leu Val Leu Ala Asp
            180                 185                 190         
Lys Ser Gly Leu Ser Ser Asp Thr Leu Leu Asp Ile Leu Asp Leu Gly
        195                 200                 205             
Ala Met Thr Asn Pro Met Phe Lys Gly Lys Gly Pro Ser Met Thr Lys
    210                 215                 220                 
Ser Ser Tyr Pro Pro Ala Phe Pro Leu Lys His Gln Gln Lys Asp Met
225                 230                 235                 240 
Arg Leu Ala Leu Ala Leu Gly Asp Glu Asn Ala Val Ser Met Pro Val
                245                 250                 255     
Ala Ala Ala Ala Asn Glu Ala Phe Lys Lys Ala Arg Ser Leu Gly Leu
            260                 265                 270         
Gly Asp Leu Asp Phe Ser Ala Val Ile Glu Ala Val Lys Phe Ser Arg
        275                 280                 285             
Glu
    


<210> 7
<211> 1053
<212> DNA
<213> Artificial Sequence

<220> 
<223> Aspergillus terreus

<400> 7
atgccactgg ttgctcaaaa tccactgcca cgtgctattc tgggtctgat gactttcggt 60
ccgagcgaaa gcaaaggtgc gcgtatcact tccctggatg agtttaacaa gtgcctggat 120
tacttccagc agcagggctt ccaggaaatc gataccgcgc gcatctacgt cggcggtgaa 180
caggaggcat tcacggcgca ggcaaagtgg aaagaacgcg gcctgacgct ggcgactaag 240
tggtatccgc agtacccggg tgcgcacaaa ccggatgtcc tgcgtcagaa cctggagctg 300
tccctgaaag aactgggcac gaaccaggtc gatatcttct atctgcacgc cgcggatcgt 360
tctgtgccgt tcgcggaaac tctggaaact gttaacgaac tgcacaaaga aggcaaattt 420
gttcagctgg gtctgtctaa ctacaccgct ttcgaagtag ctgaaatcgt gaccctgtgt 480
aacgagcgtg gttgggttcg tccgactatc taccaggcga tgtataacgc tatcacccgt 540
aacatcgaaa ctgaactgat cccggcgtgc aagcgttacg gtattgacat tgttatctac 600
aacccactgg cgggtggcct gttcagcggc aaatacaaag cacaggacat cccggctgaa 660
ggtcgttaca gcgaccaatc ttccatgggc cagatgtacc gcaaccgtta ctttaaggac 720
gcaacctttg acgctctgcg cctgatcgaa ccggttgttg cgaagcacgg cctgacgatg 780
ccggaaaccg cgttccgctg ggtccaccac cactccgcac tgaacatgga agatggcggc 840
cgtgacggca tcattctggg tgtaagcagc ctggctcagc tggaaaacaa cctgaaagac 900
attcagaaag gtccgctgcc gcaggaggtt gtagacgtcc tggatcaggc ttggctggtg 960
gctaagccga cggctccaaa ctactggcat ctggacctga aatacacgta cgacacccag 1020
gaagctctgt tcaaaccgaa atctaaggcg taa                              1053

<210> 8
<211> 357
<212> PRT
<213> Artificial Sequence

<220> 
<223> Aspergillus terreus

<400> 8
Met Pro Leu Val Ala Gln Asn Pro Leu Pro Arg Ala Ile Leu Gly Leu
 1               5                  10                  15      
Met Thr Phe Gly Pro Ser Glu Ser Lys Gly Ala Arg Ile Thr Ser Leu
            20                  25                  30          
Asp Glu Phe Asn Lys Cys Leu Asp Tyr Phe Gln Gln Gln Gly Phe Gln
        35                  40                  45              
Glu Ile Asp Thr Ala Arg Ile Tyr Val Gly Gly Glu Gln Glu Ala Phe
    50                  55                  60                  
Thr Ala Gln Ala Lys Trp Lys Glu Arg Gly Leu Thr Leu Ala Thr Lys
65                  70                  75                  80  
Trp Tyr Pro Gln Tyr Pro Gly Ala His Lys Pro Asp Val Leu Arg Gln
                85                  90                  95      
Asn Leu Glu Leu Ser Leu Lys Glu Leu Gly Thr Asn Gln Val Asp Ile
            100                 105                 110         
Phe Tyr Leu His Ala Ala Asp Arg Ser Val Pro Phe Ala Glu Thr Leu
        115                 120                 125             
Glu Thr Val Asn Glu Leu His Lys Glu Gly Lys Phe Val Gln Leu Gly
    130                 135                 140                 
Leu Ser Asn Tyr Thr Ala Phe Glu Val Ala Glu Ile Val Thr Leu Cys
145                 150                 155                 160 
Asn Glu Arg Gly Trp Val Arg Pro Thr Ile Tyr Gln Ala Met Tyr Asn
                165                 170                 175     
Ala Ile Thr Arg Asn Ile Glu Thr Glu Leu Ile Pro Ala Cys Lys Arg
            180                 185                 190         
Tyr Gly Ile Asp Ile Val Ile Tyr Asn Pro Leu Ala Gly Gly Leu Phe
        195                 200                 205             
Ser Gly Lys Tyr Lys Ala Gln Asp Ile Pro Ala Glu Gly Arg Tyr Ser
    210                 215                 220                 
Asp Gln Ser Ser Met Gly Gln Met Tyr Arg Asn Arg Tyr Phe Lys Asp
225                 230                 235                 240 
Ala Thr Phe Asp Ala Leu Arg Leu Ile Glu Pro Val Val Ala Lys His
                245                 250                 255     
Gly Leu Thr Met Pro Glu Thr Ala Phe Arg Trp Val His His His Ser
            260                 265                 270         
Ala Leu Asn Met Glu Asp Gly Gly Arg Asp Gly Ile Ile Leu Gly Val
        275                 280                 285             
Ser Ser Leu Ala Gln Leu Glu Asn Asn Leu Lys Asp Ile Gln Lys Gly
    290                 295                 300                 
Pro Leu Pro Gln Glu Val Val Asp Val Leu Asp Gln Ala Trp Leu Val
305                 310                 315                 320 
Ala Lys Pro Thr Ala Pro Asn Tyr Trp His Leu Asp Leu Lys Tyr Thr
                325                 330                 335     
Tyr Asp Thr Gln Glu Ala Leu Phe Lys Pro Lys Ser Lys Ala Ala Val
            340                 345                 350         
Lys Phe Ser Arg Glu
        355         


<210> 9
<211> 1104
<212> DNA
<213> Artificial Sequence

<220> 
<223> Mus musculus

<400> 9
atgctgcgtg ctgcttctcg tgctgttggt cgtgctgctg tacgttccgc tcaacgttct 60
ggtactagcg ttggccgtcc gctggcgatg tcccgtccac cgccgcctcg cgcagctagc 120
ggtgccccgc tgcgtccggc aaccgtactg ggcactatgg agatgggtcg tcgcatggac 180
gcttctgcat ccgcggcaag cgttcgtgcg ttcctggaac gtggccatag cgaactggat 240
accgctttca tgtattgcga cggtcagtcc gaaaatatcc tgggtggcct gggcctgggt 300
ctgggctccg gtgattgtac cgttaaaatt gcgaccaagg cgaacccttg ggagggcaag 360
agcctgaagc cggattctgt gcgttctcag ctggagactt ctctgaaacg tctgcagtgt 420
ccgcgcgtag acctgttcta tctgcatgcg ccggaccaca gcactccggt agaggaaact 480
ctgcgtgcgt gtcatcagct gcaccaggaa ggcaagttcg tcgaactggg tctgtctaac 540
tacgcatctt gggaagtggc agaaatctgt acgctgtgta agtctaatgg ttggatcctg 600
ccaaccgtgt accagggcat gtacaacgct accacccgcc aggtagaagc agaactgctg 660
ccgtgcctgc gtcacttcgg cctgcgcttt tacgcttaca acccgctggc gggtggtctg 720
ctgacgggca aatacaagta tgaagataaa gatggtaaac aaccggtcgg tcgtttcttt 780
ggtaacaact gggccgaaac ctaccgtaat cgcttctgga aagagcacca ctttgaagcg 840
atcgcactgg ttgaaaaagc gctgcagacg acttatggca ctaacgcgcc gcgtatgacc 900
tccgctgcgc tgcgttggat gtaccaccat agccagctgc agggtactcg cggcgatgcc 960
gttatcctgg gcatgagctc cctggaacag ctggaacaga acctggccgc gactgaagag 1020
ggcccgctgg aaccggcagt tgtcgaagct tttgaccagg catggaacat ggtggcgcac 1080
gaatgtccaa actatttccg ctaa                                        1104

<210> 10
<211> 367
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mus musculus

<400> 10
Met Leu Arg Ala Ala Ser Arg Ala Val Gly Arg Ala Ala Val Arg Ser
 1               5                  10                  15      
Ala Gln Arg Ser Gly Thr Ser Val Gly Arg Pro Leu Ala Met Ser Arg
            20                  25                  30          
Pro Pro Pro Pro Arg Ala Ala Ser Gly Ala Pro Leu Arg Pro Ala Thr
        35                  40                  45              
Val Leu Gly Thr Met Glu Met Gly Arg Arg Met Asp Ala Ser Ala Ser
    50                  55                  60                  
Ala Ala Ser Val Arg Ala Phe Leu Glu Arg Gly His Ser Glu Leu Asp
65                  70                  75                  80  
Thr Ala Phe Met Tyr Cys Asp Gly Gln Ser Glu Asn Ile Leu Gly Gly
                85                  90                  95      
Leu Gly Leu Gly Leu Gly Ser Gly Asp Cys Thr Val Lys Ile Ala Thr
            100                 105                 110         
Lys Ala Asn Pro Trp Glu Gly Lys Ser Leu Lys Pro Asp Ser Val Arg
        115                 120                 125             
Ser Gln Leu Glu Thr Ser Leu Lys Arg Leu Gln Cys Pro Arg Val Asp
    130                 135                 140                 
Leu Phe Tyr Leu His Ala Pro Asp His Ser Thr Pro Val Glu Glu Thr
145                 150                 155                 160 
Leu Arg Ala Cys His Gln Leu His Gln Glu Gly Lys Phe Val Glu Leu
                165                 170                 175     
Gly Leu Ser Asn Tyr Ala Ser Trp Glu Val Ala Glu Ile Cys Thr Leu
            180                 185                 190         
Cys Lys Ser Asn Gly Trp Ile Leu Pro Thr Val Tyr Gln Gly Met Tyr
        195                 200                 205             
Asn Ala Thr Thr Arg Gln Val Glu Ala Glu Leu Leu Pro Cys Leu Arg
    210                 215                 220                 
His Phe Gly Leu Arg Phe Tyr Ala Tyr Asn Pro Leu Ala Gly Gly Leu
225                 230                 235                 240 
Leu Thr Gly Lys Tyr Lys Tyr Glu Asp Lys Asp Gly Lys Gln Pro Val
                245                 250                 255     
Gly Arg Phe Phe Gly Asn Asn Trp Ala Glu Thr Tyr Arg Asn Arg Phe
            260                 265                 270         
Trp Lys Glu His His Phe Glu Ala Ile Ala Leu Val Glu Lys Ala Leu
        275                 280                 285             
Gln Thr Thr Tyr Gly Thr Asn Ala Pro Arg Met Thr Ser Ala Ala Leu
    290                 295                 300                 
Arg Trp Met Tyr His His Ser Gln Leu Gln Gly Thr Arg Gly Asp Ala
305                 310                 315                 320 
Val Ile Leu Gly Met Ser Ser Leu Glu Gln Leu Glu Gln Asn Leu Ala
                325                 330                 335     
Ala Thr Glu Glu Gly Pro Leu Glu Pro Ala Val Val Glu Ala Phe Asp
            340                 345                 350         
Gln Ala Trp Asn Met Val Ala His Glu Cys Pro Asn Tyr Phe Arg
        355                 360                 365         


<210> 11
<211> 1821
<212> DNA
<213> Artificial Sequence

<220> 
<223> Pseudomonas putida/Ralstonia eutropha

<400> 11
atgactagaa ggaggtttca tatgagtaac aagaacaacg atgagctggc gacgggtaaa 60
ggtgctgctg catcttctac tgaaggtaaa tctcagccgt ttaaattccc accgggtccg 120
ctggacccgg ccacttggct ggaatggagc cgtcagtggc aaggtccgga gggcaatggc 180
ggtaccgtgc cgggtggctt tccgggtttc gaagcgttcg cggcgtcccc gctggcgggc 240
gtgaaaatcg acccggctca gctggcagag atccagcagc gttatatgcg tgatttcacc 300
gagctgtggc gtggtctggc aggcggtgac accgagagcg ctggcaaact gcatgaccgt 360
cgcttcgcgt ccgaagcgtg gcacaaaaac gcgccgtatc gctatactgc ggcattttac 420
ctgctgaacg cacgtgcact gacggaactg gctgatgcag tagaagcgga tccgaaaacc 480
cgtcagcgta tccgttttgc ggtttcccag tgggtagatg ctatgagccc ggctaacttc 540
ctggccacca acccggacgc tcagaaccgt ctgatcgaga gccgtggtga aagcctgcgt 600
gccggcatgc gcaatatgct ggaagatctg acccgcggta aaatttccca aaccgatgag 660
actgccttcg aagtaggccg taacatggca gttaccgaag gtgctgtggt attcgaaaac 720
gagttcttcc agctgctgca gtacaaacct ctgactgaca aagtatacac ccgtccgctg 780
ctgctggtac cgccgtgcat taacaagttc tatattctgg acctgcagcc ggaaggttct 840
ctggtccgtt acgcagtcga acagggtcac actgtattcc tggtgagctg gcgcaatcca 900
gacgctagca tggctggctg tacctgggat gactatattg aaaacgcggc tatccgcgcc 960
atcgaggttg tgcgtgatat cagcggtcag gacaagatca acaccctggg cttttgtgtt 1020
ggtggcacga tcatctccac tgccctggcg gtcctggccg cccgtggtga gcacccggtg 1080
gcctctctga ccctgctgac taccctgctg gacttcaccg atactggtat cctggatgtt 1140
ttcgtggacg agccacacgt tcagctgcgt gaggcgactc tgggcggcgc cagcggcggt 1200
ctgctgcgtg gtgtcgagct ggccaatacc ttttccttcc tgcgcccgaa cgacctggtt 1260
tggaactacg ttgttgacaa ctatctgaaa ggcaacaccc cggtaccttt cgatctgctg 1320
ttctggaacg gtgatgcaac caacctgcct ggtccatggt actgttggta cctgcgtcat 1380
acttacctgc agaacgaact gaaagagccg ggcaaactga ccgtgtgtaa cgaacctgtg 1440
gacctgggcg cgattaacgt tcctacttac atctacggtt cccgtgaaga tcacatcgta 1500
ccgtggaccg cggcttacgc cagcaccgcg ctgctgaaga acgatctgcg tttcgtactg 1560
ggcgcatccg gccatatcgc aggtgtgatc aaccctcctg caaagaaaaa gcgttctcat 1620
tggaccaacg acgcgctgcc agaatccgcg caggattggc tggcaggtgc tgaggaacac 1680
catggttcct ggtggccgga ttggatgacc tggctgggta aacaagccgg tgcaaaacgt 1740
gcagctccaa ctgaatatgg tagcaagcgt tatgctgcaa tcgagccagc gccaggccgt 1800
tacgttaaag cgaaagcata a                                           1821

<210> 12
<211> 599
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pseudomonas putida/Ralstonia eutropha

<400> 12
Met Ser Asn Lys Asn Asn Asp Glu Leu Ala Thr Gly Lys Gly Ala Ala
 1               5                  10                  15      
Ala Ser Ser Thr Glu Gly Lys Ser Gln Pro Phe Lys Phe Pro Pro Gly
            20                  25                  30          
Pro Leu Asp Pro Ala Thr Trp Leu Glu Trp Ser Arg Gln Trp Gln Gly
        35                  40                  45              
Pro Glu Gly Asn Gly Gly Thr Val Pro Gly Gly Phe Pro Gly Phe Glu
    50                  55                  60                  
Ala Phe Ala Ala Ser Pro Leu Ala Gly Val Lys Ile Asp Pro Ala Gln
65                  70                  75                  80  
Leu Ala Glu Ile Gln Gln Arg Tyr Met Arg Asp Phe Thr Glu Leu Trp
                85                  90                  95      
Arg Gly Leu Ala Gly Gly Asp Thr Glu Ser Ala Gly Lys Leu His Asp
            100                 105                 110         
Arg Arg Phe Ala Ser Glu Ala Trp His Lys Asn Ala Pro Tyr Arg Tyr
        115                 120                 125             
Thr Ala Ala Phe Tyr Leu Leu Asn Ala Arg Ala Leu Thr Glu Leu Ala
    130                 135                 140                 
Asp Ala Val Glu Ala Asp Pro Lys Thr Arg Gln Arg Ile Arg Phe Ala
145                 150                 155                 160 
Val Ser Gln Trp Val Asp Ala Met Ser Pro Ala Asn Phe Leu Ala Thr
                165                 170                 175     
Asn Pro Asp Ala Gln Asn Arg Leu Ile Glu Ser Arg Gly Glu Ser Leu
            180                 185                 190         
Arg Ala Gly Met Arg Asn Met Leu Glu Asp Leu Thr Arg Gly Lys Ile
        195                 200                 205             
Ser Gln Thr Asp Glu Thr Ala Phe Glu Val Gly Arg Asn Met Ala Val
    210                 215                 220                 
Thr Glu Gly Ala Val Val Phe Glu Asn Glu Phe Phe Gln Leu Leu Gln
225                 230                 235                 240 
Tyr Lys Pro Leu Thr Asp Lys Val Tyr Thr Arg Pro Leu Leu Leu Val
                245                 250                 255     
Pro Pro Cys Ile Asn Lys Phe Tyr Ile Leu Asp Leu Gln Pro Glu Gly
            260                 265                 270         
Ser Leu Val Arg Tyr Ala Val Glu Gln Gly His Thr Val Phe Leu Val
        275                 280                 285             
Ser Trp Arg Asn Pro Asp Ala Ser Met Ala Gly Cys Thr Trp Asp Asp
    290                 295                 300                 
Tyr Ile Glu Asn Ala Ala Ile Arg Ala Ile Glu Val Val Arg Asp Ile
305                 310                 315                 320 
Ser Gly Gln Asp Lys Ile Asn Thr Leu Gly Phe Cys Val Gly Gly Thr
                325                 330                 335     
Ile Ile Ser Thr Ala Leu Ala Val Leu Ala Ala Arg Gly Glu His Pro
            340                 345                 350         
Val Ala Ser Leu Thr Leu Leu Thr Thr Leu Leu Asp Phe Thr Asp Thr
        355                 360                 365             
Gly Ile Leu Asp Val Phe Val Asp Glu Pro His Val Gln Leu Arg Glu
    370                 375                 380                 
Ala Thr Leu Gly Gly Ala Ser Gly Gly Leu Leu Arg Gly Val Glu Leu
385                 390                 395                 400 
Ala Asn Thr Phe Ser Phe Leu Arg Pro Asn Asp Leu Val Trp Asn Tyr
                405                 410                 415     
Val Val Asp Asn Tyr Leu Lys Gly Asn Thr Pro Val Pro Phe Asp Leu
            420                 425                 430         
Leu Phe Trp Asn Gly Asp Ala Thr Asn Leu Pro Gly Pro Trp Tyr Cys
        435                 440                 445             
Trp Tyr Leu Arg His Thr Tyr Leu Gln Asn Glu Leu Lys Glu Pro Gly
    450                 455                 460                 
Lys Leu Thr Val Cys Asn Glu Pro Val Asp Leu Gly Ala Ile Asn Val
465                 470                 475                 480 
Pro Thr Tyr Ile Tyr Gly Ser Arg Glu Asp His Ile Val Pro Trp Thr
                485                 490                 495     
Ala Ala Tyr Ala Ser Thr Ala Leu Leu Lys Asn Asp Leu Arg Phe Val
            500                 505                 510         
Leu Gly Ala Ser Gly His Ile Ala Gly Val Ile Asn Pro Pro Ala Lys
        515                 520                 525             
Lys Lys Arg Ser His Trp Thr Asn Asp Ala Leu Pro Glu Ser Ala Gln
    530                 535                 540                 
Asp Trp Leu Ala Gly Ala Glu Glu His His Gly Ser Trp Trp Pro Asp
545                 550                 555                 560 
Trp Met Thr Trp Leu Gly Lys Gln Ala Gly Ala Lys Arg Ala Ala Pro
                565                 570                 575     
Thr Glu Tyr Gly Ser Lys Arg Tyr Ala Ala Ile Glu Pro Ala Pro Gly
            580                 585                 590         
Arg Tyr Val Lys Ala Lys Ala
        595                 

