
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Watkins, Jeffry D.
      Buechler, Ying Ji
      Wu, Chi-Fang
      Do, Minh-Ha T.
      Vasserot, Alain P.
      Mendlein, John D.

<120> PEGYLATED TYROSYL-TRNA SYNTHETASE
  POLYPEPTIDES

<130> ATYR-104/00US

<150> US 61/521,696                 
<151> 2011-08-09  

<160> 115

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 528
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             
Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala
    370                 375                 380                 
Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg
385                 390                 395                 400 
Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln
                405                 410                 415     
Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg
            420                 425                 430         
Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile
        435                 440                 445             
Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly
    450                 455                 460                 
Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu
465                 470                 475                 480 
Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys
                485                 490                 495     
Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr
            500                 505                 510         
Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
        515                 520                 525             


<210> 2
<211> 1587
<212> DNA
<213> Homo sapiens

<400> 2
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtg tgaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctgt gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg gccaaaggcc ctgccaagaa ttcagaacca 1080
gaggaggtca tcccatcccg gctggatatc cgtgtgggga aaatcatcac tgtggagaag 1140
cacccagatg cagacagcct gtatgtagag aagattgacg tgggggaagc tgaaccacgg 1200
actgtggtga gcggcctggt acagttcgtg cccaaggagg aactgcagga caggctggta 1260
gtggtgctgt gcaacctgaa accccagaag atgagaggag tcgagtccca aggcatgctt 1320
ctgtgtgctt ctatagaagg gataaaccgc caggttgaac ctctggaccc tccggcaggc 1380
tctgctcctg gtgagcacgt gtttgtgaag ggctatgaaa agggccaacc agatgaggag 1440
ctcaagccca agaagaaagt cttcgagaag ttgcaggctg acttcaaaat ttctgaggag 1500
tgcatcgcac agtggaagca aaccaacttc atgaccaagc tgggctccat ttcctgtaaa 1560
tcgctgaaag gggggaacat tagctag                                     1587

<210> 3
<211> 329
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn
                325                 


<210> 4
<211> 343
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp
            340             


<210> 5
<211> 344
<212> PRT
<213> Homo sapiens

<400> 5
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro
            340                 


<210> 6
<211> 350
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met
            340                 345                 350 


<210> 7
<211> 353
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly
    


<210> 8
<211> 364
<212> PRT
<213> Homo sapiens

<400> 8
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile
        355                 360                 


<210> 9
<211> 368
<212> PRT
<213> Homo sapiens

<400> 9
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             


<210> 10
<211> 382
<212> PRT
<213> Homo sapiens

<400> 10
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             
Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro
    370                 375                 380         


<210> 11
<211> 388
<212> PRT
<213> Homo sapiens

<400> 11
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             
Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala
    370                 375                 380                 
Asp Ser Leu Tyr
385             


<210> 12
<211> 395
<212> PRT
<213> Homo sapiens

<400> 12
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             
Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala
    370                 375                 380                 
Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly
385                 390                 395 


<210> 13
<211> 266
<212> PRT
<213> Homo sapiens

<400> 13
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
 1               5                  10                  15      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            20                  25                  30          
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        35                  40                  45              
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    50                  55                  60                  
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
65                  70                  75                  80  
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                85                  90                  95      
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            100                 105                 110         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        115                 120                 125             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    130                 135                 140                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
145                 150                 155                 160 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                165                 170                 175     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            180                 185                 190         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        195                 200                 205             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    210                 215                 220                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
225                 230                 235                 240 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                245                 250                 255     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys
            260                 265     


<210> 14
<211> 260
<212> PRT
<213> Homo sapiens

<400> 14
Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr Tyr Glu Asn Val Ile Lys
 1               5                  10                  15      
Ala Met Leu Glu Ser Ile Gly Val Pro Leu Glu Lys Leu Lys Phe Ile
            20                  25                  30          
Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu Tyr Thr Leu Asp Val Tyr
        35                  40                  45              
Arg Leu Ser Ser Val Val Thr Gln His Asp Ser Lys Lys Ala Gly Ala
    50                  55                  60                  
Glu Val Val Lys Gln Val Glu His Pro Leu Leu Ser Gly Leu Leu Tyr
65                  70                  75                  80  
Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr Leu Lys Val Asp Ala Gln
                85                  90                  95      
Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe Thr Phe Ala Glu Lys Tyr
            100                 105                 110         
Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val His Leu Met Asn Pro Met
        115                 120                 125             
Val Pro Gly Leu Thr Gly Ser Lys Met Ser Ser Ser Glu Glu Glu Ser
    130                 135                 140                 
Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp Val Lys Lys Lys Leu Lys
145                 150                 155                 160 
Lys Ala Phe Cys Glu Pro Gly Asn Val Glu Asn Asn Gly Val Leu Ser
                165                 170                 175     
Phe Ile Lys His Val Leu Phe Pro Leu Lys Ser Glu Phe Val Ile Leu
            180                 185                 190         
Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr Val Asp
        195                 200                 205             
Leu Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp Leu Lys
    210                 215                 220                 
Asn Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu
225                 230                 235                 240 
Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro
                245                 250                 255     
Asp Pro Ser Lys
            260 


<210> 15
<211> 201
<212> PRT
<213> Homo sapiens

<400> 15
Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp
 1               5                  10                  15      
Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu
            20                  25                  30          
Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile
        35                  40                  45              
Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys
    50                  55                  60                  
Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val
65                  70                  75                  80  
Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu
                85                  90                  95      
Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met
            100                 105                 110         
Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu
        115                 120                 125             
Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly
    130                 135                 140                 
Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val
145                 150                 155                 160 
Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala
                165                 170                 175     
Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys
            180                 185                 190         
Lys Ser Leu Lys Gly Gly Asn Ile Ser
        195                 200     


<210> 16
<211> 189
<212> PRT
<213> Homo sapiens

<400> 16
Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala
 1               5                  10                  15      
Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg
            20                  25                  30          
Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu
        35                  40                  45              
Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val
    50                  55                  60                  
Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu
65                  70                  75                  80  
Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu
                85                  90                  95      
Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln
            100                 105                 110         
Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val
        115                 120                 125             
Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro
    130                 135                 140                 
Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu
145                 150                 155                 160 
Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly
                165                 170                 175     
Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
            180                 185                 


<210> 17
<211> 168
<212> PRT
<213> Homo sapiens

<400> 17
Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile
 1               5                  10                  15      
Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile
            20                  25                  30          
Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln
        35                  40                  45              
Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys
    50                  55                  60                  
Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu
65                  70                  75                  80  
Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp
                85                  90                  95      
Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr
            100                 105                 110         
Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe
        115                 120                 125             
Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln
    130                 135                 140                 
Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys
145                 150                 155                 160 
Ser Leu Lys Gly Gly Asn Ile Ser
                165             


<210> 18
<211> 139
<212> PRT
<213> Homo sapiens

<400> 18
Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly
 1               5                  10                  15      
Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val
            20                  25                  30          
Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln
        35                  40                  45              
Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu
    50                  55                  60                  
Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe Val
65                  70                  75                  80  
Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys
                85                  90                  95      
Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys
            100                 105                 110         
Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile
        115                 120                 125             
Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
    130                 135                 


<210> 19
<211> 60
<212> PRT
<213> Homo sapiens

<400> 19
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Ser Gln Trp Pro Lys Ala Leu Pro Arg Ile Gln Asn Gln
            20                  25                  30          
Arg Arg Ser Ser His Pro Gly Trp Ile Ser Val Trp Gly Lys Ser Ser
        35                  40                  45              
Leu Trp Arg Ser Thr Gln Met Gln Thr Ala Cys Met
    50                  55                  60  


<210> 20
<211> 348
<212> PRT
<213> Homo sapiens

<400> 20
Met Pro Asn Leu Glu Ala Leu Ile Arg Glu Ile Phe Thr Phe Ala Glu
 1               5                  10                  15      
Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val His Leu Met Asn
            20                  25                  30          
Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser Ser Ser Glu Glu
        35                  40                  45              
Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp Val Lys Lys Lys
    50                  55                  60                  
Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu Asn Asn Gly Val
65                  70                  75                  80  
Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys Ser Glu Phe Val
                85                  90                  95      
Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr
            100                 105                 110         
Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp
        115                 120                 125             
Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile
    130                 135                 140                 
Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala
145                 150                 155                 160 
Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys
                165                 170                 175     
Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val
            180                 185                 190         
Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr
        195                 200                 205             
Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser
    210                 215                 220                 
Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val
225                 230                 235                 240 
Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser
                245                 250                 255     
Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val
            260                 265                 270         
Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe
        275                 280                 285             
Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys
    290                 295                 300                 
Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu
305                 310                 315                 320 
Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser
                325                 330                 335     
Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
            340                 345             


<210> 21
<211> 388
<212> PRT
<213> Homo sapiens

<400> 21
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Leu Pro Arg Ile Gln Asn Gln Arg Arg Ser Ser His Pro Gly Trp
        355                 360                 365             
Ile Ser Val Trp Gly Lys Ser Ser Leu Trp Arg Ser Thr Gln Met Gln
    370                 375                 380                 
Thr Ala Cys Met
385             


<210> 22
<211> 318
<212> PRT
<213> Homo sapiens

<400> 22
Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser Ser Ser
 1               5                  10                  15      
Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp Val Lys
            20                  25                  30          
Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu Asn Asn
        35                  40                  45              
Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys Ser Glu
    50                  55                  60                  
Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr
65                  70                  75                  80  
Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val His Pro
                85                  90                  95      
Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp
            100                 105                 110         
Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser
        115                 120                 125             
Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro
    130                 135                 140                 
Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile
145                 150                 155                 160 
Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser
                165                 170                 175     
Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val
            180                 185                 190         
Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg
        195                 200                 205             
Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val
    210                 215                 220                 
Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg
225                 230                 235                 240 
Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His
                245                 250                 255     
Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys
            260                 265                 270         
Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser
        275                 280                 285             
Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu
    290                 295                 300                 
Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
305                 310                 315             


<210> 23
<211> 179
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro
 1               5                  10                  15      
Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His
            20                  25                  30          
Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala
        35                  40                  45              
Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu
    50                  55                  60                  
Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln
65                  70                  75                  80  
Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile
                85                  90                  95      
Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser
            100                 105                 110         
Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro
        115                 120                 125             
Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala
    130                 135                 140                 
Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn
145                 150                 155                 160 
Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly
                165                 170                 175     
Asn Ile Ser
            


<210> 24
<211> 188
<212> PRT
<213> Homo sapiens

<400> 24
Met Gly Phe Phe Ser Phe Pro Glu Pro Met Ala Lys Gly Pro Ala Lys
 1               5                  10                  15      
Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val
            20                  25                  30          
Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr
        35                  40                  45              
Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser
    50                  55                  60                  
Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val
65                  70                  75                  80  
Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser
                85                  90                  95      
Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val
            100                 105                 110         
Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe
        115                 120                 125             
Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys
    130                 135                 140                 
Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu
145                 150                 155                 160 
Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser
                165                 170                 175     
Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser
            180                 185             


<210> 25
<211> 377
<212> PRT
<213> Homo sapiens

<400> 25
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Ala Leu Asp Glu Glu Tyr Leu Lys Val Asp Ala Gln Phe
            20                  25                  30          
Gly Gly Ile Asp Gln Arg Lys Ile Phe Thr Phe Ala Glu Lys Tyr Leu
        35                  40                  45              
Pro Ala Leu Gly Tyr Ser Lys Arg Val His Leu Met Asn Pro Met Val
    50                  55                  60                  
Pro Gly Leu Thr Gly Ser Lys Met Ser Ser Ser Glu Glu Glu Ser Lys
65                  70                  75                  80  
Ile Asp Leu Leu Asp Arg Lys Glu Asp Val Lys Lys Lys Leu Lys Lys
                85                  90                  95      
Ala Phe Cys Glu Pro Gly Asn Val Glu Asn Asn Gly Val Leu Ser Phe
            100                 105                 110         
Ile Lys His Val Leu Phe Pro Leu Lys Ser Glu Phe Val Ile Leu Arg
        115                 120                 125             
Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr Val Asp Leu
    130                 135                 140                 
Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp Leu Lys Asn
145                 150                 155                 160 
Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu Lys
                165                 170                 175     
Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp
            180                 185                 190         
Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu
        195                 200                 205             
Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile
    210                 215                 220                 
Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys
225                 230                 235                 240 
Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val
                245                 250                 255     
Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu
            260                 265                 270         
Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met
        275                 280                 285             
Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu
    290                 295                 300                 
Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly
305                 310                 315                 320 
Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val
                325                 330                 335     
Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala
            340                 345                 350         
Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys
        355                 360                 365             
Lys Ser Leu Lys Gly Gly Asn Ile Ser
    370                 375         


<210> 26
<211> 454
<212> PRT
<213> Homo sapiens

<400> 26
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Val Val His Pro Gly Asp Leu Lys Asn Ser Val Glu
225                 230                 235                 240 
Val Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr
                245                 250                 255     
Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys
            260                 265                 270         
Gln Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu
        275                 280                 285             
Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val
    290                 295                 300                 
Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val
305                 310                 315                 320 
Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val
                325                 330                 335     
Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu
            340                 345                 350         
Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys
        355                 360                 365             
Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro
    370                 375                 380                 
Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys
385                 390                 395                 400 
Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys
                405                 410                 415     
Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys
            420                 425                 430         
Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu
        435                 440                 445             
Lys Gly Gly Asn Ile Ser
    450                 


<210> 27
<211> 245
<212> PRT
<213> Homo sapiens

<400> 27
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Val Val His Pro Gly Asp Leu Lys Asn Ser Val Glu Val
            20                  25                  30          
Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro
        35                  40                  45              
Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln
    50                  55                  60                  
Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val
65                  70                  75                  80  
Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu
                85                  90                  95      
Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly
            100                 105                 110         
Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val Pro
        115                 120                 125             
Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys
    130                 135                 140                 
Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala
145                 150                 155                 160 
Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala
                165                 170                 175     
Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly
            180                 185                 190         
Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu
        195                 200                 205             
Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln
    210                 215                 220                 
Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys
225                 230                 235                 240 
Gly Gly Asn Ile Ser
                245 


<210> 28
<211> 377
<212> PRT
<213> Homo sapiens

<400> 28
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Ala Leu Asp Glu Glu Tyr Leu Lys Val Asp Ala Gln Phe
            20                  25                  30          
Gly Gly Ile Asp Gln Arg Lys Ile Phe Thr Phe Ala Glu Lys Tyr Leu
        35                  40                  45              
Pro Ala Leu Gly Tyr Ser Lys Arg Val His Leu Met Asn Pro Met Val
    50                  55                  60                  
Pro Gly Leu Thr Gly Ser Lys Met Ser Ser Ser Glu Glu Glu Ser Lys
65                  70                  75                  80  
Ile Asp Leu Leu Asp Arg Lys Glu Asp Val Lys Lys Lys Leu Lys Lys
                85                  90                  95      
Ala Phe Cys Glu Pro Gly Asn Val Glu Asn Asn Gly Val Leu Ser Phe
            100                 105                 110         
Ile Lys His Val Leu Phe Pro Leu Lys Ser Glu Phe Val Ile Leu Arg
        115                 120                 125             
Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr Val Asp Leu
    130                 135                 140                 
Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp Leu Lys Asn
145                 150                 155                 160 
Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu Lys
                165                 170                 175     
Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp
            180                 185                 190         
Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu
        195                 200                 205             
Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile
    210                 215                 220                 
Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys
225                 230                 235                 240 
Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val
                245                 250                 255     
Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu
            260                 265                 270         
Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met
        275                 280                 285             
Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu
    290                 295                 300                 
Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly
305                 310                 315                 320 
Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val
                325                 330                 335     
Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala
            340                 345                 350         
Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys
        355                 360                 365             
Lys Ser Leu Lys Gly Gly Asn Ile Ser
    370                 375         


<210> 29
<211> 497
<212> PRT
<213> Homo sapiens

<400> 29
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu
        195                 200                 205             
Asp Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val
    210                 215                 220                 
Glu Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu
225                 230                 235                 240 
Lys Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys
                245                 250                 255     
Thr Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val
            260                 265                 270         
Val His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys
        275                 280                 285             
Leu Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys
    290                 295                 300                 
Leu Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala
305                 310                 315                 320 
Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg
                325                 330                 335     
Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp
            340                 345                 350         
Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro
        355                 360                 365             
Arg Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu
    370                 375                 380                 
Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met
385                 390                 395                 400 
Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly
                405                 410                 415     
Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro
            420                 425                 430         
Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu
        435                 440                 445             
Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe
    450                 455                 460                 
Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met
465                 470                 475                 480 
Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile
                485                 490                 495     
Ser
    


<210> 30
<211> 230
<212> PRT
<213> Homo sapiens

<400> 30
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Ser Leu
225                 230 


<210> 31
<211> 343
<212> PRT
<213> Homo sapiens

<400> 31
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Ser Gln
    290                 295                 300                 
Trp Pro Lys Ala Leu Pro Arg Ile Gln Asn Gln Arg Arg Ser Ser His
305                 310                 315                 320 
Pro Gly Trp Ile Ser Val Trp Gly Lys Ser Ser Leu Trp Arg Ser Thr
                325                 330                 335     
Gln Met Gln Thr Ala Cys Met
            340             


<210> 32
<211> 387
<212> PRT
<213> Homo sapiens

<400> 32
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu
        355                 360                 365             
Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys Arg Arg Asp Lys
    370                 375                 380                 
Pro Pro Gly
385         


<210> 33
<211> 470
<212> PRT
<213> Homo sapiens

<400> 33
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Glu Ser Lys Ile Asp Leu
                165                 170                 175     
Leu Asp Arg Lys Glu Asp Val Lys Lys Lys Leu Lys Lys Ala Phe Cys
            180                 185                 190         
Glu Pro Gly Asn Val Glu Asn Asn Gly Val Leu Ser Phe Ile Lys His
        195                 200                 205             
Val Leu Phe Pro Leu Lys Ser Glu Phe Val Ile Leu Arg Asp Glu Lys
    210                 215                 220                 
Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp
225                 230                 235                 240 
Phe Ala Ala Glu Val Val His Pro Gly Asp Leu Lys Asn Ser Val Glu
                245                 250                 255     
Val Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr
            260                 265                 270         
Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys
        275                 280                 285             
Gln Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu
    290                 295                 300                 
Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val
305                 310                 315                 320 
Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val
                325                 330                 335     
Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val
            340                 345                 350         
Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu
        355                 360                 365             
Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys
    370                 375                 380                 
Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro
385                 390                 395                 400 
Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys
                405                 410                 415     
Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys
            420                 425                 430         
Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys
        435                 440                 445             
Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu
    450                 455                 460                 
Lys Gly Gly Asn Ile Ser
465                 470 


<210> 34
<211> 454
<212> PRT
<213> Homo sapiens

<400> 34
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu
        275                 280                 285             
Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val
    290                 295                 300                 
Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val
305                 310                 315                 320 
Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val
                325                 330                 335     
Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu
            340                 345                 350         
Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys
        355                 360                 365             
Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro
    370                 375                 380                 
Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys
385                 390                 395                 400 
Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys
                405                 410                 415     
Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys
            420                 425                 430         
Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu
        435                 440                 445             
Lys Gly Gly Asn Ile Ser
    450                 


<210> 35
<211> 18
<212> PRT
<213> Homo sapiens

<400> 35
Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn
 1               5                  10                  15      
Ile Ser
        


<210> 36
<211> 1587
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized DNA encoding the full length TyrRS
      synthetase containing the Y341A mutation

<400> 36
atgggtgatg caccgtcacc ggaagaaaaa ctgcatctga ttacccgtaa tctgcaggaa 60
gttctgggcg aagaaaaact gaaagaaatt ctgaaagaac gcgaactgaa aatctattgg 120
ggcaccgcaa ccaccggtaa accgcatgtt gcatattttg tgccgatgag caaaattgcc 180
gattttctga aagccggttg tgaagttacc attctgtttg ctgatctgca tgcctatctg 240
gataatatga aagcaccgtg ggaactgctg gaactgcgtg ttagctatta tgaaaatgtg 300
attaaagcca tgctggaaag cattggtgtt ccgctggaaa aactgaaatt tattaaaggc 360
accgattatc agctgtccaa agaatatacc ctggatgttt atcgtctgag cagcgttgtt 420
acccagcatg atagcaaaaa agccggtgcc gaagttgtta aacaggttga acatccgctg 480
ctgtctggtc tgctgtatcc gggtctgcag gcactggatg aagaatatct gaaagtggat 540
gcacagtttg gtggtattga tcagcgcaaa atttttacct ttgccgaaaa atatctgcct 600
gcactgggct atagcaaacg tgttcatctg atgaatccga tggttccggg tctgaccggt 660
agcaaaatga gcagcagcga agaagaaagc aaaattgatc tgctggatcg caaagaagat 720
gtgaaaaaaa aactgaaaaa agccttttgc gaaccgggta atgtggaaaa taatggcgtt 780
ctgagcttta ttaaacatgt gctgtttccg ctgaaaagcg aatttgtgat tctgcgtgat 840
gaaaaatggg gtggcaataa aacctatacc gcctatgtgg atctggaaaa agattttgca 900
gccgaagttg tgcatccggg tgatctgaaa aatagcgtgg aagtggccct gaataaactg 960
ctggatccga ttcgcgaaaa atttaataca ccggcactga aaaaactggc aagcgcagca 1020
gcaccggatc cgagcaaaca gaaaccgatg gcaaaaggtc cggcaaaaaa cagcgaaccg 1080
gaagaagtta ttccgagccg tctggatatt cgtgtgggca aaattattac cgtggaaaaa 1140
catccggatg cagatagcct gtatgtggaa aaaattgatg tgggtgaagc agaaccgcgt 1200
accgttgtta gcggtctggt tcagtttgtt ccgaaagaag aactgcagga tcgtctggtt 1260
gttgttctgt gtaatctgaa accgcagaaa atgcgtggtg ttgaaagcca gggtatgctg 1320
ctgtgtgcaa gcattgaagg tattaatcgt caggttgaac cgctggatcc tccggctggt 1380
tctgcaccgg gtgaacatgt ttttgtgaaa ggctatgaaa aaggtcagcc ggatgaagaa 1440
ctgaaaccga aaaaaaaagt gtttgaaaaa ctgcaggccg attttaaaat tagcgaagaa 1500
tgcattgcac agtggaaaca gaccaatttt atgaccaaac tgggtagcat tagctgtaaa 1560
agcctgaaag gtggcaatat tagctaa                                     1587

<210> 37
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer used to amplify coY341A gene

<400> 37
ctttaagaag gagatataca tatgggtgat gcaccgtcac cg                    42

<210> 38
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer used to amplify coY341A gene

<400> 38
gtggtggtgg tggtgctcga gttagctaat attgccacct ttcag                 45

<210> 39
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 39
gaaaggtggc aatattagct aatgagatcc ggctgctaac aaagc                 45

<210> 40
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 40
gctttgttag cagccggatc tcattagcta atattgccac ctttc                 45

<210> 41
<211> 86
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 41
atcgagatct cgatcccgcg aaatgagctg ttgacaatta atcatcggct cgtataatgt 60
gtggaattgt gagcggataa caattc                                      86

<210> 42
<211> 86
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 42
gaattgttat ccgctcacaa ttccacacat tatacgagcc gatgattaat tgtcaacagc 60
tcatttcgcg ggatcgagat ctcgat                                      86

<210> 43
<211> 53
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 43
cactgaaaaa actggcaagc gcagcatatc cggatccgag caaacagaaa ccg        53

<210> 44
<211> 53
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 44
cggtttctgt ttgctcggat ccggatatgc tgcgcttgcc agttttttca gtg        53

<210> 45
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 45
gggctttgtt agcagccgga tctcattaac cttttgccat cggtttctg             49

<210> 46
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 46
gcagatcagc aaacagaatg gtaacttcgc taccggcttt cagaaaatcg gcaattttgc 60


<210> 47
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 47
attattttcc acattacccg gttcgctaaa ggcttttttc agtttttttt tcacatcttc 60


<210> 48
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 48
ggagatatac atatgggtga ttgcccgtca ccggaagaaa aactg                 45

<210> 49
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 49
cagtttttct tccggtgacg ggcaatcacc catatgtata tctcc                 45

<210> 50
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 50
ccgagcaaac agaaaccgat gtgcaaaggt taatgagatc cggct                 45

<210> 51
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 51
agccggatct cattaacctt tgcacatcgg tttctgtttg ctcgg                 45

<210> 52
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 52
ccgagcaaac agaaaccgat ggcaaaaggt catcatcatc atcatcatta atgagatccg 60
gctgctaaca aagcccga                                               78

<210> 53
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 53
tcgggctttg ttagcagccg gatctcatta atgatgatga tgatgatgac cttttgccat 60
cggtttctgt ttgctcgg                                               78

<210> 54
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 54
ccgagcaaac agaaaccgat gtgcaaaggt catcatcatc atcatcatta atgagatccg 60
gctgctaaca aagcccga                                               78

<210> 55
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 55
tcgggctttg ttagcagccg gatctcatta atgatgatga tgatgatgac ctttgcacat 60
cggtttctgt ttgctcgg                                               78

<210> 56
<211> 1059
<212> DNA
<213> Artificial Sequence

<220> 
<223> polynucleotide encoding non-tagged YRS A4C point
      mutation polypeptide

<220> 
<221> misc_feature   
<222> 12
<223> n = T or C

<220> 
<221> misc_feature   
<222> 201
<223> n = A, T, C or G

<220> 
<221> misc_feature   
<222> 750
<223> n = A, T, C or G

<400> 56
atgggggact gncccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtc ngaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctcn gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg gccaaaggc                        1059

<210> 57
<211> 1059
<212> DNA
<213> Artificial Sequence

<220> 
<223> polynucleotide encoding non-tagged YRS A351C point
      mutation polypeptide

<220> 
<221> misc_feature   
<222> 201
<223> n = A, T, C or G

<220> 
<221> misc_feature   
<222> 750
<223> n = A, T, C or G

<220> 
<221> misc_feature   
<222> 1053
<223> n = T or C

<400> 57
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtc ngaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctcn gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg tgnaaaggc                        1059

<210> 58
<211> 353
<212> PRT
<213> Artificial Sequence

<220> 
<223> Non-tagged YRS A4C point mutation polypeptide

<400> 58
Met Gly Asp Cys Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Ser Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Ser Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly
    


<210> 59
<211> 353
<212> PRT
<213> Artificial Sequence

<220> 
<223> Non-tagged YRS A351C point mutation polypeptide

<400> 59
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Ser Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Ser Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Cys Lys
            340                 345                 350         
Gly
    


<210> 60
<211> 1077
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding tagged YRS A4C point
      mutation polypeptide

<220> 
<221> misc_feature   
<222> 12
<223> n = T or C

<220> 
<221> misc_feature   
<222> 201
<223> n = A, T, C or G

<220> 
<221> misc_feature   
<222> 750
<223> n = A, T, C or G

<220> 
<221> misc_feature   
<222> 1062, 1065, 1068, 1071, 1074, 1077
<223> n = T or C

<400> 60
atgggggact gncccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtc ngaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctcn gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg gccaaaggcc ancancanca ncancan    1077

<210> 61
<211> 1077
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding tagged YRS A351C point
      mutation polypeptide

<220> 
<221> misc_feature   
<222> 201
<223> n = A, T, C or G

<220> 
<221> misc_feature   
<222> 750
<223> n = A, T, C or G

<220> 
<221> misc_feature   
<222> 1053
<223> n = T or C

<220> 
<221> misc_feature   
<222> 1062, 1065, 1068, 1071, 1074, 1077
<223> n = T or C

<400> 61
atgggggacg ctcccagccc tgaagagaaa ctgcacctta tcacccggaa cctgcaggag 60
gttctggggg aagagaagct gaaggagata ctgaaggagc gggaacttaa aatttactgg 120
ggaacggcaa ccacgggcaa accacatgtg gcttactttg tgcccatgtc aaagattgca 180
gacttcttaa aggcagggtc ngaggtaaca attctgtttg cggacctcca cgcatacctg 240
gataacatga aagccccatg ggaacttcta gaactccgag tcagttacta tgagaatgtg 300
atcaaagcaa tgctggagag cattggtgtg cccttggaga agctcaagtt catcaaaggc 360
actgattacc agctcagcaa agagtacaca ctagatgtgt acagactctc ctccgtggtc 420
acacagcacg attccaagaa ggctggagct gaggtggtaa agcaggtgga gcaccctttg 480
ctgagtggcc tcttataccc cggactgcag gctttggatg aagagtattt aaaagtagat 540
gcccaatttg gaggcattga tcagagaaag attttcacct ttgcagagaa gtacctccct 600
gcacttggct attcaaaacg ggtccatctg atgaatccta tggttccagg attaacaggc 660
agcaaaatga gctcttcaga agaggagtcc aagattgatc tccttgatcg gaaggaggat 720
gtgaagaaaa aactgaagaa ggccttctcn gagccaggaa atgtggagaa caatggggtt 780
ctgtccttca tcaagcatgt cctttttccc cttaagtccg agtttgtgat cctacgagat 840
gagaaatggg gtggaaacaa aacctacaca gcttacgtgg acctggaaaa ggactttgct 900
gctgaggttg tacatcctgg agacctgaag aattctgttg aagtcgcact gaacaagttg 960
ctggatccaa tccgggaaaa gtttaatacc cctgccctga aaaaactggc cagcgctgcc 1020
tacccagatc cctcaaagca gaagccaatg tgnaaaggcc ancancanca ncancan    1077

<210> 62
<211> 359
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tagged YRS A4C point mutation polypeptide

<400> 62
Met Gly Asp Cys Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Ser Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Ser Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly His His His His His His
        355                 


<210> 63
<211> 359
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tagged YRS A351C point mutation polypeptide

<400> 63
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Ser Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Ser Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Cys Lys
            340                 345                 350         
Gly His His His His His His
        355                 


<210> 64
<211> 26
<212> DNA
<213> Homo sapiens

<400> 64
tgccccactc caagtcctca ctcaca                                      26

<210> 65
<211> 25
<212> DNA
<213> Homo sapiens

<400> 65
agaagcacac agaagcatgc cttgg                                       25

<210> 66
<211> 26
<212> DNA
<213> Homo sapiens

<400> 66
gcacagcacc actaccagcc tgtcct                                      26

<210> 67
<211> 25
<212> DNA
<213> Homo sapiens

<400> 67
cagttcctcc ttgggcacga actgt                                       25

<210> 68
<211> 26
<212> DNA
<213> Homo sapiens

<400> 68
tatccagccg ggatgggatg acctcc                                      26

<210> 69
<211> 25
<212> DNA
<213> Homo sapiens

<400> 69
ctggttctga attcttggca gggcc                                       25

<210> 70
<211> 26
<212> DNA
<213> Homo sapiens

<400> 70
ggccagcgct gcctacccag atccct                                      26

<210> 71
<211> 25
<212> DNA
<213> Homo sapiens

<400> 71
aaagcagagt aaggccagct ggaga                                       25

<210> 72
<211> 26
<212> DNA
<213> Homo sapiens

<400> 72
ggttctgaat tcttggcagg gccttt                                      26

<210> 73
<211> 25
<212> DNA
<213> Homo sapiens

<400> 73
ggccattggc tctgggaatg agaag                                       25

<210> 74
<211> 26
<212> DNA
<213> Homo sapiens

<400> 74
ggagagcatt ggtgtgccct tggaga                                      26

<210> 75
<211> 25
<212> DNA
<213> Homo sapiens

<400> 75
gctcaagttc atcaaaggca ctgat                                       25

<210> 76
<211> 26
<212> DNA
<213> Homo sapiens

<400> 76
ccacatgtgg cttactttgt gcccat                                      26

<210> 77
<211> 25
<212> DNA
<213> Homo sapiens

<400> 77
tcaaagattg cagacttctt aaagg                                       25

<210> 78
<211> 26
<212> DNA
<213> Homo sapiens

<400> 78
agactctcct ccgtggtcac acagca                                      26

<210> 79
<211> 25
<212> DNA
<213> Homo sapiens

<400> 79
gattccaaga aggctggagc tgagg                                       25

<210> 80
<211> 26
<212> DNA
<213> Homo sapiens

<400> 80
gtgatcctac gagatgagaa atgggg                                      26

<210> 81
<211> 25
<212> DNA
<213> Homo sapiens

<400> 81
ggaaacaaaa cctacacagc ttacg                                       25

<210> 82
<211> 26
<212> DNA
<213> Homo sapiens

<400> 82
aaaccacatg tggcttactt tgtgcc                                      26

<210> 83
<211> 25
<212> DNA
<213> Homo sapiens

<400> 83
atgtcaaaga ttgcagactt cttaa                                       25

<210> 84
<211> 26
<212> DNA
<213> Homo sapiens

<400> 84
ccatgggaac ttctagaact ccgagt                                      26

<210> 85
<211> 25
<212> DNA
<213> Homo sapiens

<400> 85
agttactatg agaatgtgat caaag                                       25

<210> 86
<211> 26
<212> DNA
<213> Homo sapiens

<400> 86
agtggcctct tataccccgg actgca                                      26

<210> 87
<211> 25
<212> DNA
<213> Homo sapiens

<400> 87
gtacttaagg gggatggagt ggccc                                       25

<210> 88
<211> 26
<212> DNA
<213> Homo sapiens

<400> 88
agttcctcct tgggcacgaa ctgtac                                      26

<210> 89
<211> 25
<212> DNA
<213> Homo sapiens

<400> 89
aggccgctca ccacagtccg tggtt                                       25

<210> 90
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Thrombin cleavalbe linkage

<400> 90
Gly Arg Gly Asp
 1              


<210> 91
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Thrombin cleavalbe linkage

<400> 91
Gly Arg Gly Asp Asn Pro
 1               5      


<210> 92
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Thrombin cleavalbe linkage

<400> 92
Gly Arg Gly Asp Ser
 1               5  


<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Thrombin cleavalbe linkage

<400> 93
Gly Arg Gly Asp Ser Pro Lys
 1               5          


<210> 94
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Elastase cleavalbe linkage

<400> 94
Ala Ala Pro Val
 1              


<210> 95
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Elastase cleavalbe linkage

<400> 95
Ala Ala Pro Leu
 1              


<210> 96
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Elastase cleavalbe linkage

<400> 96
Ala Ala Pro Phe
 1              


<210> 97
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Elastase cleavalbe linkage

<400> 97
Ala Ala Pro Ala
 1              


<210> 98
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Elastase cleavable linkage

<400> 98
Ala Tyr Leu Val
 1              


<210> 99
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Matrix metalloproteinase cleavable linkage

<220> 
<221> VARIANT        
<222> 3, 6
<223> Xaa = Any amino acid

<400> 99
Gly Pro Xaa Gly Pro Xaa
 1               5      


<210> 100
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Matrix metalloproteinase cleavable linkage

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Any amino acid

<400> 100
Leu Gly Pro Xaa
 1              


<210> 101
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Matrix metalloproteinase cleavable linkage

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Any amino acid

<400> 101
Gly Pro Ile Gly Pro Xaa
 1               5      


<210> 102
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Matrix metalloproteinase cleavable linkage

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Any Amino Acid

<400> 102
Ala Pro Gly Leu Xaa
 1               5  


<210> 103
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Collagenase cleavable linkage

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Any amino acid

<400> 103
Pro Leu Gly Pro Arg Xaa
 1               5      


<210> 104
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Collagenase cleavable linkage

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Any amino acid

<400> 104
Pro Leu Gly Leu Leu Gly Xaa
 1               5          


<210> 105
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Collagenase cleavable linkage

<400> 105
Pro Gln Gly Ile Ala Gly Trp
 1               5          


<210> 106
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Collagenase cleavable linkage

<400> 106
Pro Leu Gly Cys His
 1               5  


<210> 107
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Collagenase cleavable linkage

<400> 107
Pro Leu Gly Leu Tyr Ala
 1               5      


<210> 108
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Collagenase cleavable linkage

<400> 108
Pro Leu Ala Leu Trp Ala Arg
 1               5          


<210> 109
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Collagenase cleavable linkage

<400> 109
Pro Leu Ala Tyr Trp Ala Arg
 1               5          


<210> 110
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Stromelysin cleavable linkage

<400> 110
Pro Tyr Ala Tyr Tyr Met Arg
 1               5          


<210> 111
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Gelatinase cleavable linkage

<400> 111
Pro Leu Gly Met Tyr Ser Arg
 1               5          


<210> 112
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Angiotensin converting enzyme cleavable linkage

<400> 112
Gly Asp Lys Pro
 1              


<210> 113
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Angiotensin converting enzyme cleavable linkage

<400> 113
Gly Ser Asp Lys Pro
 1               5  


<210> 114
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cathepsin B cleavable linkage

<400> 114
Ala Leu Ala Leu
 1              


<210> 115
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cathepsin B cleavable linkage

<400> 115
Gly Phe Leu Gly
 1              

