                               SEQUENCE LISTING

<110> ABBOTT BIOTHERAPEUTICS CORP.
      BIOGEN IDEC MA INC.
      STEVEN GREENBERG
      JAKE ELKINS 
   
<120> METHODS OF TREATING PROGRESSIVE FORMS OF MULTIPLE SCLEROSIS

<130> 386003-240WO (118258)

<140>
<141>

<150> 61/521,338
<151> 2011-08-08

<150> 61/521,343
<151> 2011-08-08

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 702
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(699)

<400> 1
atg gag acc gat acc ctc ctg cta tgg gtc ctc ctg cta tgg gtc cca         48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro           
1               5                   10                  15                

gga tca acc gga gat att cag atg acc cag tct cca tct acc ctc tct         96
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser           
            20                  25                  30                    

gct agc gtc ggg gat agg gtc acc ata acc tgc tct gcc agc tca agt        144
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser           
        35                  40                  45                        

ata agt tac atg cac tgg tac cag cag aag cca ggc aaa gct ccc aag        192
Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys           
    50                  55                  60                            

ctt cta att tat acc aca tcc aac ctg gct tct gga gtc cct gct cgc        240
Leu Leu Ile Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg           
65                  70                  75                  80            

ttc agt ggc agt gga tct ggg acc gag ttc acc ctc aca atc agc tct        288
Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser           
                85                  90                  95                

ctg cag cca gat gat ttc gcc act tat tac tgc cat caa agg agt act        336
Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr           
            100                 105                 110                   

tac cca ctc acg ttc ggt cag ggg acc aag gtg gag gtc aaa cga act        384
Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg Thr           
        115                 120                 125                       

gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag cag ttg        432
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu           
    130                 135                 140                           

aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc        480
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro           
145                 150                 155                 160           

aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt        528
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly           
                165                 170                 175               

aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc acc tac        576
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr           
            180                 185                 190                   

agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag aaa cac        624
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His           
        195                 200                 205                       

aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc        672
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val           
    210                 215                 220                           

aca aag agc ttc aac agg gga gag tgt tag                                702
Thr Lys Ser Phe Asn Arg Gly Glu Cys                                       
225                 230                                                   


<210> 2
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr 
            100                 105                 110         


Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210> 3
<211> 1398
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(1395)

<400> 3
atg gga tgg agc tgg atc ttt ctc ttc ctc ctg tca ggt acc gcg ggc         48
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly           
1               5                   10                  15                

gtg cac tct cag gtc cag ctt gtc cag tct ggg gct gaa gtc aag aaa         96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys           
            20                  25                  30                    

cct ggc tcg agc gtg aag gtc tcc tgc aag gct tct ggc tac acc ttt        144
Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
        35                  40                  45                        

act agc tac agg atg cac tgg gta agg cag gcc cct gga cag ggt ctg        192
Thr Ser Tyr Arg Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu           
    50                  55                  60                            

gaa tgg att gga tat att aat ccg tcg act ggg tat act gaa tac aat        240
Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn           
65                  70                  75                  80            

cag aag ttc aag gac aag gca aca att act gca gac gaa tcc acc aat        288
Gln Lys Phe Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn           
                85                  90                  95                

aca gcc tac atg gaa ctg agc agc ctg aga tct gag gac acc gca gtc        336
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val           
            100                 105                 110                   

tat tac tgt gca aga ggg ggg ggg gtc ttt gac tac tgg ggc caa gga        384
Tyr Tyr Cys Ala Arg Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly           
        115                 120                 125                       

acc ctg gtc aca gtc tcc tca gcc tcc acc aag ggc cca tcg gtc ttc        432
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe           
    130                 135                 140                           

ccc ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg        480
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu           
145                 150                 155                 160           

ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg        528
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp           
                165                 170                 175               

aac tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta        576
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu           
            180                 185                 190                   

cag tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc        624
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser           
        195                 200                 205                       

agc agc ttg ggc acc cag acc tac atc tgc aac gtg aat cac aag ccc        672
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro           
    210                 215                 220                           

agc aac acc aag gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa        720
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys           
225                 230                 235                 240           

act cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg        768
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro           
                245                 250                 255               

tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc        816
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser           
            260                 265                 270                   

cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac        864
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp           
        275                 280                 285                       

cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat        912
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn           
    290                 295                 300                           

gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt gtg        960
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val           
305                 310                 315                 320           

gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag gag       1008
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu           
                325                 330                 335               

tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa       1056
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys           
            340                 345                 350                   

acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc       1104
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr           
        355                 360                 365                       

ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg acc       1152
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr           
    370                 375                 380                           

tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag       1200
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu           
385                 390                 395                 400           

agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg ctg       1248
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu           
                405                 410                 415               

gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag       1296
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys           
            420                 425                 430                   

agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag       1344
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu           
        435                 440                 445                       

gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg ggt       1392
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly           
    450                 455                 460                           

aaa tga                                                               1398
Lys                                                                       
465                                                                       


<210> 4
<211> 465
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Arg Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210> 5
<211> 10936
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
gaattctcga gcgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg       60

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      120

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      180

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      240

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      300

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      360

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      420

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      480

gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg aaccgtcaga      540

tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg gaccgatcca      600

gcctccgcct cgatcgagac gcgtctagac caccatggga tggagctgga tctttctctt      660

cctcctgtca ggtaccgcgg gcgtgcactc tcaggtccag cttgtccagt ctggggctga      720

agtcaagaaa cctggctcga gcgtgaaggt ctcctgcaag gcttctggct acacctttac      780

tagctacagg atgcactggg taaggcaggc ccctggacag ggtctggaat ggattggata      840

tattaatccg tcgactgggt atactgaata caatcagaag ttcaaggaca aggcaacaat      900

tactgcagac gaatccacca atacagccta catggaactg agcagcctga gatctgagga      960

caccgcagtc tattactgtg caagaggggg gggggtcttt gactactggg gccaaggaac     1020

cctggtcaca gtctcctcag gtgagtcctt aaaacctcta gagctttctg gggcaggcca     1080

ggcctgacct tggctttggg gcagggaggg ggctaaggtg aggcaggtgg cgccagccag     1140

gtgcacaccc aatgcccatg agcccagaca ctggacgctg aacctcgcgg acagttaaga     1200

acccaggggc ctctgcgccc tgggcccagc tctgtcccac accgcggtca catggcacca     1260

cctctcttgc agcctccacc aagggcccat cggtcttccc cctggcaccc tcctccaaga     1320

gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc cccgaaccgg     1380

tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc     1440

tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc agcagcttgg     1500

gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag gtggacaaga     1560

aagttggtga gaggccagca cagggaggga gggtgtctgc tggaagccag gctcagcgct     1620

cctgcctgga cgcatcccgg ctatgcagcc ccagtccagg gcagcaaggc aggccccgtc     1680

tgcctcttca cccggaggcc tctgcccgcc ccactcatgc tcagggagag ggtcttctgg     1740

ctttttcccc aggctctggg caggcacagg ctaggtgccc ctaacccagg ccctgcacac     1800

aaaggggcag gtgctgggct cagacctgcc aagagccata tccgggagga ccctgcccct     1860

gacctaagcc caccccaaag gccaaactct ccactccctc agctcggaca ccttctctcc     1920

tcccagattc cagtaactcc caatcttctc tctgcagagc ccaaatcttg tgacaaaact     1980

cacacatgcc caccgtgccc aggtaagcca gcccaggcct cgccctccag ctcaaggcgg     2040

gacaggtgcc ctagagtagc ctgcatccag ggacaggccc cagccgggtg ctgacacgtc     2100

cacctccatc tcttcctcag cacctgaact cctgggggga ccgtcagtct tcctcttccc     2160

cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt     2220

ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt     2280

gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag     2340

cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc     2400

caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag gtgggacccg     2460

tggggtgcga gggccacatg gacagaggcc ggctcggccc accctctgcc ctgagagtga     2520

ccgctgtacc aacctctgtc cctacagggc agccccgaga accacaggtg tacaccctgc     2580

ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg gtcaaaggct     2640

tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag aacaactaca     2700

agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc aagctcaccg     2760

tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg catgaggctc     2820

tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatga gtgcgacggc     2880

cggcaagccc ccgctccccg ggctctcgcg gtcgcacgag gatgcttggc acgtaccccc     2940

tgtacatact tcccgggcgc ccagcatgga aataaagcac ccagcgctgc cctgggcccc     3000

tgcgagactg tgatggttct ttccacgggt caggccgagt ctgaggcctg agtggcatga     3060

gggaggcaga gcgggtccca ctgtccccac actggcccag gctgtgcagg tgtgcctggg     3120

ccgcctaggg tggggctcag ccaggggctg ccctcggcag ggtgggggat ttgccagcgt     3180

ggccctccct ccagcagcac ctgccctggg ctgggccacg ggaagcccta ggagcccctg     3240

gggacagaca cacagcccct gcctctgtag gagactgtcc tgttctgtga gcgccctgtc     3300

ctccgacctc catgcccact cgggggcatg cctagtccat gtgcgtaggg acaggccctc     3360

cctcacccat ctacccccac ggcactaacc cctggctgcc ctgcccagcc tcgcacccgc     3420

atggggacac aaccgactcc ggggacatgc actctcgggc cctgtggagg gactggtgca     3480

gatgcccaca cacacactca gcccagaccc gttcaacaaa ccccgcactg aggttggccg     3540

gccacacggc caccacacac acacgtgcac gcctcacaca cggagcctca cccgggcgaa     3600

ctgcacagca cccagaccag agcaaggtcc tcgcacacgt gaacactcct cggacacagg     3660

cccccacgag ccccacgcgg cacctcaagg cccacgagcc tctcggcagc ttctccacat     3720

gctgacctgc tcagacaaac ccagccctcc tctcacaagg gtgcccctgc agccgccaca     3780

cacacacagg ggatcacaca ccacgtcacg tccctggccc tggcccactt cccagtgccg     3840

cccttccctg caggatcctg gccttggggg agggggaggc cagaatgact ccaagagcta     3900

caggaggcag gtcagagacc ccactggaca aacagtggct ggactctgca ccataacaca     3960

caatcacagg ggagtgagct ggaattctcg agcgcgttac ataacttacg gtaaatggcc     4020

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     4080

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     4140

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     4200

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     4260

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca     4320

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     4380

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     4440

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     4500

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata     4560

gaagacaccg ggaccgatcc agcctccgcc tcgatcgaga cgcgtctaga tggagaccga     4620

taccctcctg ctatgggtcc tcctgctatg ggtcccagga tcaaccggag atattcagat     4680

gacccagtct ccatctaccc tctctgctag cgtcggggat agggtcacca taacctgctc     4740

tgccagctca agtataagtt acatgcactg gtaccagcag aagccaggca aagctcccaa     4800

gcttctaatt tataccacat ccaacctggc ttctggagtc cctgctcgct tcagtggcag     4860

tggatctggg accgagttca ccctcacaat cagctctctg cagccagatg atttcgccac     4920

ttattactgc catcaaagga gtacttaccc actcacgttc ggtcagggga ccaaggtgga     4980

ggtcaaacgt aagtacactt ttctagaaat tctaaactct gagggggtcg gatgacgtgg     5040

ccattctttg cctaaagcat tgagtttact gcaaggtcag aaaagcatgc aaagccctca     5100

gaatggctgc aaagagctcc aacaaaacaa tttagaactt tattaaggaa tagggggaag     5160

ctaggaagaa actcaaaaca tcaagatttt aaatacgctt cttggtctcc ttgctataat     5220

tatctgggat aagcatgctg ttttctgtct gtccctaaca tgctctgtga ttatccgcaa     5280

acaacacacc caagggcaga actttgttac ttaaacacca tcctgtttgc ttctttcctc     5340

aggaactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     5400

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     5460

gtggaaggtg gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga     5520

cagcaaggac agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga     5580

gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa     5640

gagcttcaac aggggagagt gttagaggga gaagtgcccc cacctgctcc tcagttccag     5700

cctgaccccc tcccatcctt tggcctctga ccctttttcc acaggggacc tacccctatt     5760

gcggtcctcc agctcatctt tcacctcacc cccctcctcc tccttggctt taattatgct     5820

aatgttggag gagaatgaat aaataaagtg aatctttgca cctgtggttt ctctctttcc     5880

tcatttaata attattatct gttgtttacc aactactcaa tttctcttat aagggactaa     5940

atatgtagtc atcctaaggc gcataaccat ttataaaaat catccttcat tctattttac     6000

cctatcatcc tctgcaagac agtcctccct caaacccaca agccttctgt cctcacagtc     6060

ccctgggcca tggtaggaga gacttgcttc cttgttttcc cctcctcagc aagccctcat     6120

agtccttttt aagggtgaca ggtcttacag tcatatatcc tttgattcaa ttccctgaga     6180

atcaaccaaa gcaaattttt caaaagaaga aacctgctat aaagagaatc attcattgca     6240

acatgatata aaataacaac acaataaaag caattaaata aacaaacaat agggaaatgt     6300

ttaagttcat catggtactt agacttaatg gaatgtcatg ccttatttac atttttaaac     6360

aggtactgag ggactcctgt ctgccaaggg ccgtattgag tactttccac aacctaattt     6420

aatccacact atactgtgag attaaaaaca ttcattaaaa tgttgcaaag gttctataaa     6480

gctgagagac aaatatattc tataactcag caatcccact tctaggatcc gggccgcatg     6540

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     6600

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     6660

gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     6720

ctaggctttt gcaaaaagct tggacacaag acaggcttgc gagatatgtt tgagaatacc     6780

actttatccc gcgtcaggga gaggcagtgc gtaaaaagac gcggactcat gtgaaatact     6840

ggtttttagt gcgccagatc tctataatct cgcgcaacct attttcccct cgaacacttt     6900

ttaagccgta gataaacagg ctgggacact tcacatgagc gaaaaataca tcgtcacctg     6960

ggacatgttg cagatccatg cacgtaaact cgcaagccga ctgatgcctt ctgaacaatg     7020

gaaaggcatt attgccgtaa gccgtggcgg tctggtaccg ggtgcgttac tggcgcgtga     7080

actgggtatt cgtcatgtcg ataccgtttg tatttccagc tacgatcacg acaaccagcg     7140

cgagcttaaa gtgctgaaac gcgcagaagg cgatggcgaa ggcttcatcg ttattgatga     7200

cctggtggat accggtggta ctgcggttgc gattcgtgaa atgtatccaa aagcgcactt     7260

tgtcaccatc ttcgcaaaac cggctggtcg tccgctggtt gatgactatg ttgttgatat     7320

cccgcaagat acctggattg aacagccgtg ggatatgggc gtcgtattcg tcccgccaat     7380

ctccggtcgc taatcttttc aacgcctggc actgccgggc gttgttcttt ttaacttcag     7440

gcgggttaca atagtttcca gtaagtattc tggaggctgc atccatgaca caggcaaacc     7500

tgagcgaaac cctgttcaaa ccccgcttta aacatcctga aacctcgacg ctagtccgcc     7560

gctttaatca cggcgcacaa ccgcctgtgc agtcggccct tgatggtaaa accatccctc     7620

actggtatcg catgattaac cgtctgatgt ggatctggcg cggcattgac ccacgcgaaa     7680

tcctcgacgt ccaggcacgt attgtgatga gcgatgccga acgtaccgac gatgatttat     7740

acgatacggt gattggctac cgtggcggca actggattta tgagtgggcc ccggatcttt     7800

gtgaaggaac cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa     7860

agctctaagg taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt     7920

gtttgtgtat tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc     7980

tttaatgagg aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact     8040

gctgactctc aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac     8100

tttccttcag aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct     8160

tgctttgcta tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa     8220

aaatattctg taacctttat aagtaggcat aacagttata atcataacat actgtttttt     8280

cttactccac acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc     8340

tttagctttt taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact     8400

agagatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     8460

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat     8520

tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt     8580

tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg     8640

gatcctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     8700

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     8760

cagcgggtgt tggcgggtgt cggggcgcag ccatgaccca gtcacgtagc gatagcggag     8820

tgtatactgg cttaactatg cggcatcaga gcagattgta ctgagagtgc accatatgcg     8880

gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgct cttccgcttc     8940

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc     9000

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc     9060

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag     9120

gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc     9180

gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt     9240

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct     9300

ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg     9360

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct     9420

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat     9480

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg     9540

ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa     9600

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt     9660

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc     9720

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt     9780

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta     9840

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat     9900

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac     9960

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg    10020

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag    10080

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt    10140

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctgcag gcatcgtggt    10200

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt    10260

tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt    10320

cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct    10380

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt    10440

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaacac gggataatac    10500

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa    10560

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa    10620

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca    10680

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct    10740

ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga    10800

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc    10860

tgacgtctaa gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag    10920

gccctttcgt cttcaa                                                    10936


<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ser Ala Ser Ser Ser Ile Ser Tyr Met His 
1               5                   10  


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Thr Thr Ser Asn Leu Ala Ser 
1               5           


<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
His Gln Arg Ser Thr Tyr Pro Leu Thr 
1               5                   


<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ser Tyr Arg Met His 
1               5   


<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Gly Gly Val Phe Asp Tyr 
1               5           


<210> 12
<211> 206
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc atcccgcccc       60

taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg      120

cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga ggcttttttg      180

gaggcctagg cttttgcaaa aagctt                                           206


<210> 13
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15  


<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
1               5                   10                  15  


