                         SEQUENCE LISTING

<110>  The Coca-Cola Company
       The University of North Carolina
       Radhakrishna, Harish
       Brown, Michael D
       Siderovski, David Peter
       Kimple, Adam
       Cohen, Staci
 
<120>  CELL LINES COMPRISING ENDOGENOUS TASTE RECEPTORS AND THEIR USES

<130>  10031-014WO1

<150>  US 61/521,129
<151>  2011-08-08

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  1

Leu Pro Phe Asn Gln Leu 
1               5       


<210>  2
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  2

Leu Pro Phe Ser Gln Leu 
1               5       


<210>  3
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  3

Tyr Gln Glu Pro Val Leu Gly Pro Val Arg Gly Pro Phe Pro Ile Ile 
1               5                   10                  15      


Val 
    


<210>  4
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  4

Pro Val Leu Gly Pro Val Arg Gly Pro Phe Pro Ile Ile Val 
1               5                   10                  


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  5

Pro Val Arg Gly Pro Phe Pro Ile Ile Val 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  6

Arg Gly Pro Phe Pro Ile Ile Val 
1               5               


<210>  7
<211>  1795
<212>  DNA
<213>  Homo sapiens

<400>  7
ggttaccact tggaaaacaa ttcatctgaa agaagcacag attttctcat ctatcctgtc       60

aacaaagaaa gaatcaagag agcaaggaca gtgatttccc ccgcattgca tttgtcttga      120

agatcagtca gaaagagaaa ctcggcatca tctgtgacag acagtggaac gaaaaatgcc      180

agtgaaatgc tgtttctaca ggtcaccaac tgcggaaaca atgacatggt ctgaaaatat      240

ggacacgctt ttagccaacc aagctggtct agatgctttt cgaatatttc taaaatcaga      300

gtttagtgaa gaaaatgttg agttctggct tgcctgtgaa gactttaaga aaacgaaaaa      360

tgcagacaaa attgcttcca aagccaagat gatttattct gaattcattg aagctgatgc      420

acctaaagag attaacattg acttcggtac cagagacctc atctcaaaga atattgctga      480

accaacactc aaatgctttg atgaggctca gaaattaatc tattgtctca tggccaagga      540

ttctttccct cgatttctga agtcagagat ttataaaaaa ctggtaaata gccaacaggt      600

tccaaatcat aaaaaatggc tccctttttt gtgaggaagg taaaagttaa ctaatcacta      660

tacttcaggg ctacaatatt ttaaatatac aagcatgatg cattgtcttt tgttttgttt      720

ttaggattta gaaaacattt tttacccaaa cagatgaata acgttttata caacaagcct      780

gaatttctaa ctcagttgtt tagaatgtat ttgctttacc agctatttaa tctcctactg      840

ggggagtaca aagaaagttt atagagatac aatatagtct taaaccaaaa ctgaatattc      900

ttattatatt ataatgtaag gaattataca catcttcacg tggcagaatg aaagactttt      960

gagcatcata tacacaattt taaataccat tgctttattc aaaaaaatct cacttttgta     1020

aaaagagaat ttctgaacca aaatacaagt tttcatttaa tatatttaac tgtttttttt     1080

ctgccatttc tttccaacta tttctaataa tgtggttatg aaaactgcta cgcctctcaa     1140

attatatttt ttaaatcaca ggaatgtata cacatttata tgtatgtctt gaatgcacca     1200

tggaccaaag tttttcaaaa tatatcactt ggctcaattc aatggcatca catataaaat     1260

gtgatgagtt atgtatgaaa aggcctcaag ggtggggaat actgattttc ttatgttaac     1320

agaaatataa aagaaagtgg aagactaagg agcatagata aatccttata agatgaagta     1380

tatagcaagt cataaaattt aagaatttgc aacattatct actcaattgt ggggaagtat     1440

ctattcactc cttcagcact gatacttgtt tataaaaccc aaacaatttt taaatgcatt     1500

tattttgaga tgttcctaaa attgtttcat tctatatgta aatatcctgt gataaatacg     1560

aataatttca tttcaatatg agaagctgta aagattcaac agatctccca cgtttccatt     1620

ttctttgcac agatttattt atctgcattg atatttctgc ttttagattg tttgaacatt     1680

aaaaaatgga ggaaaaatag catggcttat tttatgtttt cacaaactac tcatttgata     1740

gacaaaattt tgtcttccct tcatcatgag aaataaacat ttaaacatat tcaaa          1795


<210>  8
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Val Lys Cys Cys Phe Tyr Arg Ser Pro Thr Ala Glu Thr Met 
1               5                   10                  15      


Thr Trp Ser Glu Asn Met Asp Thr Leu Leu Ala Asn Gln Ala Gly Leu 
            20                  25                  30          


Asp Ala Phe Arg Ile Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Val 
        35                  40                  45              


Glu Phe Trp Leu Ala Cys Glu Asp Phe Lys Lys Thr Lys Asn Ala Asp 
    50                  55                  60                  


Lys Ile Ala Ser Lys Ala Lys Met Ile Tyr Ser Glu Phe Ile Glu Ala 
65                  70                  75                  80  


Asp Ala Pro Lys Glu Ile Asn Ile Asp Phe Gly Thr Arg Asp Leu Ile 
                85                  90                  95      


Ser Lys Asn Ile Ala Glu Pro Thr Leu Lys Cys Phe Asp Glu Ala Gln 
            100                 105                 110         


Lys Leu Ile Tyr Cys Leu Met Ala Lys Asp Ser Phe Pro Arg Phe Leu 
        115                 120                 125             


Lys Ser Glu Ile Tyr Lys Lys Leu Val Asn Ser Gln Gln Val Pro Asn 
    130                 135                 140                 


His Lys Lys Trp Leu Pro Phe Leu 
145                 150         


<210>  9
<211>  930
<212>  DNA
<213>  Homo sapiens

<400>  9
atgataactt ttctgcccat cattttttcc attctaatag tggttacatt tgtgattgga       60

aattttgcta atggcttcat agcattggta aattccattg agtggttcaa gagacaaaag      120

atctcttttg ctgaccaaat tctcactgct ctggcagtct ccagagttgg tttactctgg      180

gtattagtat taaattggta tgcaactgag ttgaatccag cttttaacag tatagaagta      240

agaattactg cttacaatgt ctgggcagta atcaaccatt tcagcaactg gcttgctact      300

agcctcagca tattttattt gctcaagatt gccaatttct ccaaccttat ttttcttcac      360

ttaaagagga gagttaagag tgttgttctg gtgatactat tggggccttt gctatttttg      420

gtttgtcatc tttttgtgat aaacatgaat cagattatat ggacaaaaga atatgaagga      480

aacatgactt ggaagatcaa actgaggagt gcaatgtacc tttcaaatac aacggtaacc      540

atcctagcaa acttagttcc cttcactctg accctgatat cttttctgct gttaatctgt      600

tctctgtgta aacatctcaa aaagatgcag ctccatggca aaggatctca agatcccagc      660

atgaaggtcc acataaaagc tttgcaaact gtgacctcct tcctcttgtt atgtgccatt      720

tactttctgt ccataatcat gtcagtttgg agttttgaga gtctggaaaa caaacctgtc      780

ttcatgttct gcgaagctat tgcattcagc tatccttcaa cccacccatt catcctgatt      840

tggggaaaca agaagctaaa gcagactttt ctttcagttt tgtggcatgt gaggtactgg      900

gtgaaaggag agaagccttc atcttcatag                                       930


<210>  10
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Ile Val Val Thr 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Ile Glu Trp Phe Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Val Leu 
    50                  55                  60                  


Asn Trp Tyr Ala Thr Glu Leu Asn Pro Ala Phe Asn Ser Ile Glu Val 
65                  70                  75                  80  


Arg Ile Thr Ala Tyr Asn Val Trp Ala Val Ile Asn His Phe Ser Asn 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Val Leu Val Ile Leu Leu Gly Pro Leu Leu Phe Leu Val Cys His Leu 
    130                 135                 140                 


Phe Val Ile Asn Met Asn Gln Ile Ile Trp Thr Lys Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Met Thr Trp Lys Ile Lys Leu Arg Ser Ala Met Tyr Leu Ser Asn 
                165                 170                 175     


Thr Thr Val Thr Ile Leu Ala Asn Leu Val Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Ile Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Met Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Ser Ile Ile Met Ser Val Trp Ser Phe Glu Ser Leu Glu 
                245                 250                 255     


Asn Lys Pro Val Phe Met Phe Cys Glu Ala Ile Ala Phe Ser Tyr Pro 
            260                 265                 270         


Ser Thr His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Trp His Val Arg Tyr Trp Val Lys Gly Glu 
    290                 295                 300                 


Lys Pro Ser Ser Ser 
305                 


<210>  11
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  11
cctttctgca ctgggtggca accaggtctt tagattagcc aactagagaa gagaagtaga       60

atagccaatt agagaagtga catcatgttg actctaactc gcatccgcac tgtgtcctat      120

gaagtcagga gtacatttct gttcatttca gtcctggagt ttgcagtggg gtttctgacc      180

aatgccttcg ttttcttggt gaatttttgg gatgtagtga agaggcaggc actgagcaac      240

agtgattgtg tgctgctgtg tctcagcatc agccggcttt tcctgcatgg actgctgttc      300

ctgagtgcta tccagcttac ccacttccag aagttgagtg aaccactgaa ccacagctac      360

caagccatca tcatgctatg gatgattgca aaccaagcca acctctggct tgctgcctgc      420

ctcagcctgc tttactgctc caagctcatc cgtttctctc acaccttcct gatctgcttg      480

gcaagctggg tctccaggaa gatctcccag atgctcctgg gtattattct ttgctcctgc      540

atctgcactg tcctctgtgt ttggtgcttt tttagcagac ctcacttcac agtcacaact      600

gtgctattca tgaataacaa tacaaggctc aactggcaga ttaaagatct caatttattt      660

tattcctttc tcttctgcta tctgtggtct gtgcctcctt tcctattgtt tctggtttct      720

tctgggatgc tgactgtctc cctgggaagg cacatgagga caatgaaggt ctataccaga      780

aactctcgtg accccagcct ggaggcccac attaaagccc tcaagtctct tgtctccttt      840

ttctgcttct ttgtgatatc atcctgtgtt gccttcatct ctgtgcccct actgattctg      900

tggcgcgaca aaataggggt gatggtttgt gttgggataa tggcagcttg tccctctggg      960

catgcagcca tcctgatctc aggcaatgcc aagttgagga gagctgtgat gaccattctg     1020

ctctgggctc agagcagcct gaaggtaaga gccgaccaca aggcagattc ccggacactg     1080

tgctgagaat ggacatgaaa tgagctcttc attaatacgc ctgtgagtct tcataaatat     1140

gcc                                                                   1143


<210>  12
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Thr Leu Thr Arg Ile Arg Thr Val Ser Tyr Glu Val Arg Ser 
1               5                   10                  15      


Thr Phe Leu Phe Ile Ser Val Leu Glu Phe Ala Val Gly Phe Leu Thr 
            20                  25                  30          


Asn Ala Phe Val Phe Leu Val Asn Phe Trp Asp Val Val Lys Arg Gln 
        35                  40                  45              


Ala Leu Ser Asn Ser Asp Cys Val Leu Leu Cys Leu Ser Ile Ser Arg 
    50                  55                  60                  


Leu Phe Leu His Gly Leu Leu Phe Leu Ser Ala Ile Gln Leu Thr His 
65                  70                  75                  80  


Phe Gln Lys Leu Ser Glu Pro Leu Asn His Ser Tyr Gln Ala Ile Ile 
                85                  90                  95      


Met Leu Trp Met Ile Ala Asn Gln Ala Asn Leu Trp Leu Ala Ala Cys 
            100                 105                 110         


Leu Ser Leu Leu Tyr Cys Ser Lys Leu Ile Arg Phe Ser His Thr Phe 
        115                 120                 125             


Leu Ile Cys Leu Ala Ser Trp Val Ser Arg Lys Ile Ser Gln Met Leu 
    130                 135                 140                 


Leu Gly Ile Ile Leu Cys Ser Cys Ile Cys Thr Val Leu Cys Val Trp 
145                 150                 155                 160 


Cys Phe Phe Ser Arg Pro His Phe Thr Val Thr Thr Val Leu Phe Met 
                165                 170                 175     


Asn Asn Asn Thr Arg Leu Asn Trp Gln Ile Lys Asp Leu Asn Leu Phe 
            180                 185                 190         


Tyr Ser Phe Leu Phe Cys Tyr Leu Trp Ser Val Pro Pro Phe Leu Leu 
        195                 200                 205             


Phe Leu Val Ser Ser Gly Met Leu Thr Val Ser Leu Gly Arg His Met 
    210                 215                 220                 


Arg Thr Met Lys Val Tyr Thr Arg Asn Ser Arg Asp Pro Ser Leu Glu 
225                 230                 235                 240 


Ala His Ile Lys Ala Leu Lys Ser Leu Val Ser Phe Phe Cys Phe Phe 
                245                 250                 255     


Val Ile Ser Ser Cys Val Ala Phe Ile Ser Val Pro Leu Leu Ile Leu 
            260                 265                 270         


Trp Arg Asp Lys Ile Gly Val Met Val Cys Val Gly Ile Met Ala Ala 
        275                 280                 285             


Cys Pro Ser Gly His Ala Ala Ile Leu Ile Ser Gly Asn Ala Lys Leu 
    290                 295                 300                 


Arg Arg Ala Val Met Thr Ile Leu Leu Trp Ala Gln Ser Ser Leu Lys 
305                 310                 315                 320 


Val Arg Ala Asp His Lys Ala Asp Ser Arg Thr Leu Cys 
                325                 330             


