                         SEQUENCE LISTING

<110>  IMHOF, BEAT A.
       MILJKOVIC-LICINA, MARIJANA
       HAMMEL, PHILIPPE
 
<120>  IMPROVED METHODS AND COMPOSITIONS FOR MODULATION OF OLFML3 
       MEDIATED ANGIOGENESIS

<130>  CLFR.P0379WO

<140>  UNKNOWN
<141>  2012-07-25

<150>  61/664,491
<151>  2012-06-26

<150>  61/515,669
<151>  2011-08-05

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Pro Ser Thr Pro Leu Leu Ile Leu Phe Leu Leu Ser Trp Ser 
1               5                   10                  15      


Gly Pro Leu Gln Gly Gln Gln His His Leu Val Glu Tyr Met Glu Arg 
            20                  25                  30          


Arg Leu Ala Ala Leu Glu Glu Arg Leu Ala Gln Cys Gln Asp Gln Ser 
        35                  40                  45              


Ser Arg His Ala Ala Glu Leu Arg Asp Phe Lys Asn Lys Met Leu Pro 
    50                  55                  60                  


Leu Leu Glu Val Ala Glu Lys Glu Arg Glu Ala Leu Arg Thr Glu Ala 
65                  70                  75                  80  


Asp Thr Ile Ser Gly Arg Val Asp Arg Leu Glu Arg Glu Val Asp Tyr 
                85                  90                  95      


Leu Glu Thr Gln Asn Pro Ala Leu Pro Cys Val Glu Phe Asp Glu Lys 
            100                 105                 110         


Val Thr Gly Gly Pro Gly Thr Lys Gly Lys Gly Arg Arg Asn Glu Lys 
        115                 120                 125             


Tyr Asp Met Val Thr Asp Cys Gly Tyr Thr Ile Ser Gln Val Arg Ser 
    130                 135                 140                 


Met Lys Ile Leu Lys Arg Phe Gly Gly Pro Ala Gly Leu Trp Thr Lys 
145                 150                 155                 160 


Asp Pro Leu Gly Gln Thr Glu Lys Ile Tyr Val Leu Asp Gly Thr Gln 
                165                 170                 175     


Asn Asp Thr Ala Phe Val Phe Pro Arg Leu Arg Asp Phe Thr Leu Ala 
            180                 185                 190         


Met Ala Ala Arg Lys Ala Ser Arg Val Arg Val Pro Phe Pro Trp Val 
        195                 200                 205             


Gly Thr Gly Gln Leu Val Tyr Gly Gly Phe Leu Tyr Phe Ala Arg Arg 
    210                 215                 220                 


Pro Pro Gly Arg Pro Gly Gly Gly Gly Glu Met Glu Asn Thr Leu Gln 
225                 230                 235                 240 


Leu Ile Lys Phe His Leu Ala Asn Arg Thr Val Val Asp Ser Ser Val 
                245                 250                 255     


Phe Pro Ala Glu Gly Leu Ile Pro Pro Tyr Gly Leu Thr Ala Asp Thr 
            260                 265                 270         


Tyr Ile Asp Leu Ala Ala Asp Glu Glu Gly Leu Trp Ala Val Tyr Ala 
        275                 280                 285             


Thr Arg Glu Asp Asp Arg His Leu Cys Leu Ala Lys Leu Asp Pro Gln 
    290                 295                 300                 


Thr Leu Asp Thr Glu Gln Gln Trp Asp Thr Pro Cys Pro Arg Glu Asn 
305                 310                 315                 320 


Ala Glu Ala Ala Phe Val Ile Cys Gly Thr Leu Tyr Val Val Tyr Asn 
                325                 330                 335     


Thr Arg Pro Ala Ser Arg Ala Arg Ile Gln Cys Ser Phe Asp Ala Ser 
            340                 345                 350         


Gly Thr Leu Thr Pro Glu Arg Ala Ala Leu Pro Tyr Phe Pro Arg Arg 
        355                 360                 365             


Tyr Gly Ala His Ala Ser Leu Arg Tyr Asn Pro Arg Glu Arg Gln Leu 
    370                 375                 380                 


Tyr Ala Trp Asp Asp Gly Tyr Gln Ile Val Tyr Lys Leu Glu Met Arg 
385                 390                 395                 400 


Lys Lys Glu Glu Glu Val 
                405     


<210>  2
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  2
caggagagaa ggcaccgccc ccaccccgcc tccaaagcta accctcgggc ttgaggggaa       60

gaggctgact gtacgttcct tctactctgg caccactctc caggctgcca tggggcccag      120

cacccctctc ctcatcttgt tccttttgtc atggtcggga cccctccaag gacagcagca      180

ccaccttgtg gagtacatgg aacgccgact agctgcttta gaggaacggc tggcccagtg      240

ccaggaccag agtagtcggc atgctgctga gctgcgggac ttcaagaaca agatgctgcc      300

actgctggag gtggcagaga aggagcggga ggcactcaga actgaggccg acaccatctc      360

cgggagagtg gatcgtctgg agcgggaggt agactatctg gagacccaga acccagctct      420

gccctgtgta gagtttgatg agaaggtgac tggaggccct gggaccaaag gcaagggaag      480

aaggaatgag aagtacgata tggtgacaga ctgtggctac acaatctctc aagtgagatc      540

aatgaagatt ctgaagcgat ttggtggccc agctggtcta tggaccaagg atccactggg      600

gcaaacagag aagatctacg tgttagatgg gacacagaat gacacagcct ttgtcttccc      660

aaggctgcgt gacttcaccc ttgccatggc tgcccggaaa gcttcccgag tccgggtgcc      720

cttcccctgg gtaggcacag ggcagctggt atatggtggc tttctttatt ttgctcggag      780

gcctcctgga agacctggtg gaggtggtga gatggagaac actttgcagc taatcaaatt      840

ccacctggca aaccgaacag tggtggacag ctcagtattc ccagcagagg ggctgatccc      900

cccctacggc ttgacagcag acacctacat cgacctggca gctgatgagg aaggtctttg      960

ggctgtctat gccacccggg aggatgacag gcacttgtgt ctggccaagt tagatccaca     1020

gacactggac acagagcagc agtgggacac accatgtccc agagagaatg ctgaggctgc     1080

ctttgtcatc tgtgggaccc tctatgtcgt ctataacacc cgtcctgcca gtcgggcccg     1140

catccagtgc tcctttgatg ccagcggcac cctgacccct gaacgggcag cactccctta     1200

ttttccccgc agatatggtg cccatgccag cctccgctat aacccccgag aacgccagct     1260

ctatgcctgg gatgatggct accagattgt ctataagctg gagatgagga agaaagagga     1320

ggaggtttga ggagctagcc ttgttttttg catctttctc actcccatac atttatatta     1380

tatccccact aaatttcttg ttcctcattc ttcaaatgtg ggccagttgt ggctcaaatc     1440

ctctatattt ttagccaatg gcaatcaaat tctttcagct cctttgtttc atacggaact     1500

ccagatcctg agtaatcctt ttagagcccg aagagtcaaa accctcaatg ttccctcctg     1560

ctctcctgcc ccatgtcaac aaatttcagg ctaaggatgc cccagaccca gggctctaac     1620

cttgtatgcg ggcaggccca gggagcaggc agcagtgttc ttcccctcag agtgacttgg     1680

ggagggagaa ataggaggag acgtccagct ctgtcctctc ttcctcactc ctcccttcag     1740

tgtcctgagg aacaggactt tctccacatt gttttgtatt gcaacatttt gcattaaaag     1800

gaaaatccac tgctaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1852


<210>  3
<211>  406
<212>  PRT
<213>  Mus musculus

<400>  3

Met Gly Pro Ser Ala Pro Leu Leu Leu Leu Phe Phe Leu Ser Trp Thr 
1               5                   10                  15      


Gly Pro Leu Gln Gly Gln Gln His His Leu Val Glu Tyr Met Glu Arg 
            20                  25                  30          


Arg Leu Ala Ala Leu Glu Glu Arg Leu Ala Gln Cys Gln Asp Gln Ser 
        35                  40                  45              


Ser Arg His Ala Ala Glu Leu Arg Asp Phe Lys Asn Lys Met Leu Pro 
    50                  55                  60                  


Leu Leu Glu Val Ala Glu Lys Glu Arg Glu Thr Leu Arg Thr Glu Ala 
65                  70                  75                  80  


Asp Ser Ile Ser Gly Arg Val Asp Arg Leu Glu Arg Glu Val Asp Tyr 
                85                  90                  95      


Leu Glu Thr Gln Asn Pro Ala Leu Pro Cys Val Glu Leu Asp Glu Lys 
            100                 105                 110         


Val Thr Gly Gly Pro Gly Ala Lys Gly Lys Gly Arg Arg Asn Glu Lys 
        115                 120                 125             


Tyr Asp Met Val Thr Asp Cys Ser Tyr Thr Val Ala Gln Val Arg Ser 
    130                 135                 140                 


Met Lys Ile Leu Lys Arg Phe Gly Gly Ser Val Gly Leu Trp Thr Lys 
145                 150                 155                 160 


Asp Pro Leu Gly Pro Ala Glu Lys Ile Tyr Val Leu Asp Gly Thr Gln 
                165                 170                 175     


Asn Asp Thr Ala Phe Val Phe Pro Arg Leu Arg Asp Phe Thr Leu Ala 
            180                 185                 190         


Met Ala Ala Arg Lys Ala Ser Arg Ile Arg Val Pro Phe Pro Trp Val 
        195                 200                 205             


Gly Thr Gly Gln Leu Val Tyr Gly Gly Phe Leu Tyr Tyr Ala Arg Arg 
    210                 215                 220                 


Pro Pro Gly Gly Pro Gly Gly Gly Gly Glu Leu Glu Asn Thr Leu Gln 
225                 230                 235                 240 


Leu Ile Lys Phe His Leu Ala Asn Arg Thr Val Val Asp Ser Ser Val 
                245                 250                 255     


Phe Pro Ala Glu Ser Leu Ile Pro Pro Tyr Gly Leu Thr Ala Asp Thr 
            260                 265                 270         


Tyr Ile Asp Leu Ala Ala Asp Glu Glu Gly Leu Trp Ala Val Tyr Ala 
        275                 280                 285             


Thr Arg Asp Asp Asp Arg His Leu Cys Leu Ala Lys Leu Asp Pro Gln 
    290                 295                 300                 


Thr Leu Asp Thr Glu Gln Gln Trp Asp Thr Pro Cys Pro Arg Glu Asn 
305                 310                 315                 320 


Ala Glu Ala Ala Phe Val Ile Cys Gly Thr Leu Tyr Val Val Tyr Asn 
                325                 330                 335     


Thr Arg Pro Ala Ser Arg Ala Arg Ile Gln Cys Ser Phe Asp Ala Ser 
            340                 345                 350         


Gly Thr Leu Ala Pro Glu Arg Ala Ala Leu Ser Tyr Phe Pro Arg Arg 
        355                 360                 365             


Tyr Gly Ala His Ala Ser Leu Arg Tyr Asn Pro Arg Glu Arg Gln Leu 
    370                 375                 380                 


Tyr Ala Trp Asp Asp Gly Tyr Gln Ile Val Tyr Lys Leu Glu Met Lys 
385                 390                 395                 400 


Lys Lys Glu Glu Glu Val 
                405     


<210>  4
<211>  1736
<212>  DNA
<213>  Mus musculus

<400>  4
agagctaacg ggctggaggg aaagaggccg aatgcacaca ctcctctggc cccacttaag       60

gctgccatgg ggcccagtgc tcctctgctg ctcctcttct ttttgtcatg gacgggaccc      120

cttcagggac agcagcacca ccttgtggag tacatggaac gccgactagc tgccttagag      180

gaacggctgg cccaatgcca ggatcagagt agtcggcatg ctgccgagct tcgggacttc      240

aaaaacaaga tgttgcctct cctggaggtg gcagagaagg agcgggagac cctcagaact      300

gaagcagact ccatctcagg aagagtggac cgtcttgaaa gggaggtaga ctatctggag      360

acacagaacc cagctttgcc ctgtgtagag ctggatgaga aggtgactgg aggtcctgga      420

gccaaaggca agggccgaag aaatgagaaa tacgatatgg tgacggactg tagctacaca      480

gtcgctcagg tgaggtcaat gaagatcctg aagcggtttg gtggttcagt tggcctatgg      540

accaaggatc cgctggggcc agcagagaag atctacgtgt tagacggcac ccagaacgac      600

acggcttttg tcttcccaag gctgcgtgac ttcacccttg ccatggctgc ccggaaagct      660

tcccgaattc gggtgccctt cccctgggta ggcacggggc agctggtgta cggtggcttc      720

ctttattatg ctcgaaggcc tcctggagga cctggagggg gtggtgaatt ggagaacact      780

ctgcagctga tcaaatttca cttggcaaac cgaacagtgg tggatagctc agtgttccct      840

gcagagagcc tgataccccc ctacggcctg acagcagata catatatcga cctggcagct      900

gatgaggagg gcctgtgggc tgtctatgcc actcgagatg atgacaggca tttgtgtcta      960

gccaagttag acccacagac acttgacaca gagcagcagt gggacacacc atgtcccaga     1020

gagaacgcag aggctgcgtt tgtcatctgt gggaccctgt acgttgtcta taacacccgc     1080

cctgccagta gggctcgtat tcagtgttcc ttcgatgcca gtggtactct cgcccctgaa     1140

agggcagcac tctcctattt tccacgccga tatggtgccc atgccagcct tcgctataac     1200

ccccgtgagc gccagctgta tgcctgggat gatggctacc agattgtcta caaattggag     1260

atgaagaaga aggaggagga agtttaagca gctagccttg tgctcttgat tcttatgccc     1320

agacatttat attcctgtga gctctcctgc agttcatcct tcaaaacgaa ggccagtggt     1380

ggtagctcat ataccctaat ttctaaagga caaccaaatt ctcaagcccc tctgttttat     1440

gcagaactcc agatcctggg tagcatttta gaactgaaca gcaaacaaac accctaaatc     1500

ttcactcctg ccttatgtcc acaaagttta gttccaaact cagagccctg tcctttggag     1560

agggtcaacc ccagacagca ggcgacagca ttcttgccct cagtatgacc gaagggagag     1620

aactcagaga caaagctgcc ctccctccct tccccctcca gtgtagggga gaatggggct     1680

ttccccacat cactttgtat ggtaacagtt tgcattaaaa ggaaaaccca ccattc         1736


<210>  5
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
ctaatacgac tcactatagg gatgctcctg gctctgggac t                           41


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
tgcagctggt ccccttctat g                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
atgctcctgg ctctgggact c                                                 21


<210>  8
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
ctaatacgac tcactatagg gtgcagctgg tccccttcta tg                          42


<210>  9
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  9
ctaatacgac tcactatagg gagtgctcct ctgctgctcc tc                          42


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  10
cgtgtcgttc tgggtgccgt c                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  11
agtgctcctc tgctgctcct c                                                 21


<210>  12
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  12
ctaatacgac tcactatagg gcgtgtcgtt ctgggtgccg tc                          42


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  13
gctgtctatg ccactcgaga tg                                                22


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  14
tgtgtcaagt gtctgtgggt ctaa                                              24


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  15
gtctatgcca cccgggagga t                                                 21


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  16
tgtgtccagt gtctgtggat ctaa                                              24


