                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS

<130>  YEDA/0118 PCT

<150>  US 61/522,259
<151>  2011-08-11

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  1

Ile Asp Ile Leu Leu Lys Ala Val Gly Asp Thr Pro 
1               5                   10          


<210>  2
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Glu Pro Gln Ser Val Leu Gln Leu Pro Thr Ser Ile Ala 
1               5                   10                  15      


Ala Gly Gly Glu Gly Leu Thr Asp Val Ser Pro Glu Thr Thr Thr Pro 
            20                  25                  30          


Glu Pro Pro Ser Ser Ala Ala Val Ser Pro Gly Thr Glu Glu Pro Ala 
        35                  40                  45              


Gly Asp Thr Lys Lys Lys Ile Asp Ile Leu Leu Lys Ala Val Gly Asp 
    50                  55                  60                  


Thr Pro Ile Met Lys Thr Lys Lys Trp Ala Val Glu Arg Thr Arg Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Ile Asp Phe Ile Lys Lys Phe Leu Lys Leu Val Ala 
                85                  90                  95      


Ser Glu Gln Leu Phe Ile Tyr Val Asn Gln Ser Phe Ala Pro Ser Pro 
            100                 105                 110         


Asp Gln Glu Val Gly Thr Leu Tyr Glu Cys Phe Gly Ser Asp Gly Lys 
        115                 120                 125             


Leu Val Leu His Tyr Cys Lys Ser Gln Ala Trp Gly 
    130                 135                 140 


<210>  3
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  3

Ile Asp Val Leu Leu Lys Ala Val Gly Asp Thr Pro 
1               5                   10          


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  4

Lys Leu Val Ala Ser 
1               5   


<210>  5
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  5

Ile Asp Val Leu Leu Lys Ala Val Gly Asp Asp Pro 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  6

Ile Asp Val Leu Leu Lys Ala Val Gly Asp Glu Pro 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  7

Ile Asp Ile Leu Leu Lys Ala Val Gly Asp Ala Pro 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = Ala, Ile, Leu, Asn, Lys, Met, Phe, Gln, Trp, Gly, Val, Pro,
       Arg or His

<400>  8

Ile Asp Ile Leu Leu Lys Ala Val Gly Asp Xaa Pro 
1               5                   10          


<210>  9
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Thr Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Arg Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  10
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  11
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Ala His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210>  12
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Thr Pro Ala Ser Ala Pro Asp Thr Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Thr Arg Phe Arg Arg Thr Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Thr Pro Gly Ser Ala Gln Gln Arg Phe Thr 
65                  70                  75                  80  


Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      


Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         


Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             


Tyr Leu Glu Thr Arg Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 


Ala Glu Phe Thr Ala Leu Tyr Gly Asp Gly Ala Leu Glu Glu Ala Arg 
145                 150                 155                 160 


Arg Leu Arg Glu Gly Asn Trp Ala Ser Val Arg Thr Val Leu Thr Gly 
                165                 170                 175     


Ala Val Ala Leu Gly Ala Leu Val Thr Val Gly Ala Phe Phe Ala Ser 
            180                 185                 190         


Lys 
    


<210>  13
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val Asp Gln Leu Arg Glu Arg Thr Thr Met Ala Asp Pro Leu Arg 
1               5                   10                  15      


Glu Arg Thr Glu Leu Leu Leu Ala Asp Tyr Leu Gly Tyr Cys Ala Arg 
            20                  25                  30          


Glu Pro Gly Thr Pro Glu Pro Ala Pro Ser Thr Pro Glu Ala Ala Val 
        35                  40                  45              


Leu Arg Ser Ala Ala Ala Arg Leu Arg Gln Ile His Arg Ser Phe Phe 
    50                  55                  60                  


Ser Ala Tyr Leu Gly Tyr Pro Gly Asn Arg Phe Glu Leu Val Ala Leu 
65                  70                  75                  80  


Met Ala Asp Ser Val Leu Ser Asp Ser Pro Gly Pro Thr Trp Gly Arg 
                85                  90                  95      


Val Val Thr Leu Val Thr Phe Ala Gly Thr Leu Leu Glu Arg Gly Pro 
            100                 105                 110         


Leu Val Thr Ala Arg Trp Lys Lys Trp Gly Phe Gln Pro Arg Leu Lys 
        115                 120                 125             


Glu Gln Glu Gly Asp Val Ala Arg Asp Cys Gln Arg Leu Val Ala Leu 
    130                 135                 140                 


Leu Ser Ser Arg Leu Met Gly Gln His Arg Ala Trp Leu Gln Ala Gln 
145                 150                 155                 160 


Gly Gly Trp Asp Gly Phe Cys His Phe Phe Arg Thr Pro Phe Pro Leu 
                165                 170                 175     


Ala Phe Trp Arg Lys Gln Leu Val Gln Ala Phe Leu Ser Cys Leu Leu 
            180                 185                 190         


Thr Thr Ala Phe Ile Tyr Leu Trp Thr Arg Leu Leu 
        195                 200                 


<210>  14
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      


Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          


Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              


Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  


Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  


Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      


Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         


Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             


Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 


Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 


Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Asp Leu Tyr Arg 
                165                 170                 175     


Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         


Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             


Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 


Glu Thr Ala Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu 
225                 230                 235                 240 


Asp Asp Val Lys Ser Leu Ser Arg Val Met Ile His Val Phe Ser Asp 
                245                 250                 255     


Gly Val Thr Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala 
            260                 265                 270         


Phe Val Ala Lys His Leu Lys Thr Ile Asn Gln Glu Ser Cys Ile Glu 
        275                 280                 285             


Pro Leu Ala Glu Ser Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp 
    290                 295                 300                 


Trp Leu Val Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His 
305                 310                 315                 320 


Val Glu Asp Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala 
                325                 330                 335     


Gly Val Ala Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
            340                 345                 350 


<210>  15
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Asp Cys Glu Phe Gly Tyr Ile Tyr Arg Leu Ala Gln Asp Tyr 
1               5                   10                  15      


Leu Gln Cys Val Leu Gln Ile Pro Gln Pro Gly Ser Gly Pro Ser Lys 
            20                  25                  30          


Thr Ser Arg Val Leu Gln Asn Val Ala Phe Ser Val Gln Lys Glu Val 
        35                  40                  45              


Glu Lys Asn Leu Lys Ser Cys Leu Asp Asn Val Asn Val Val Ser Val 
    50                  55                  60                  


Asp Thr Ala Arg Thr Leu Phe Asn Gln Val Met Glu Lys Glu Phe Glu 
65                  70                  75                  80  


Asp Gly Ile Ile Asn Trp Gly Arg Ile Val Thr Ile Phe Ala Phe Glu 
                85                  90                  95      


Gly Ile Leu Ile Lys Lys Leu Leu Arg Gln Gln Ile Ala Pro Asp Val 
            100                 105                 110         


Asp Thr Tyr Lys Glu Ile Ser Tyr Phe Val Ala Glu Phe Ile Met Asn 
        115                 120                 125             


Asn Thr Gly Glu Trp Ile Arg Gln Asn Gly Gly Trp Glu Asn Gly Phe 
    130                 135                 140                 


Val Lys Lys Phe Glu Pro Lys Ser Gly Trp Met Thr Phe Leu Glu Val 
145                 150                 155                 160 


Thr Gly Lys Ile Cys Glu Met Leu Ser Leu Leu Lys Gln Tyr Cys 
                165                 170                 175 


