                         SEQUENCE LISTING

<110>  ZICHE et al, Maria
 
<120>  Proteine ad attivit apoptotica e antitelomerasica su cellule 
       cancerose, loro preparazione ed uso

<130>  11312PTWO

<150>  FI2011A000168
<151>  2011-08-05

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  182
<212>  PRT
<213>  Python sebae


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  methylproline

<400>  1

His Lys Cys Glu Ile Cys His Gly Phe Gly Asp Asp Cys Asp Gly Tyr 
1               5                   10                  15      


Glu Glu Glu Cys Pro Ser Pro Glu Asp Lys Cys Gly Lys Ile Leu Ile 
            20                  25                  30          


Asp Ile Ala Leu Ala Xaa Val Ser Phe Arg Ala Thr His Lys Asn Cys 
        35                  40                  45              


Phe Ser Ser Ser Ile Cys Lys Leu Gly Arg Val Asp Ile His Val Trp 
    50                  55                  60                  


Asp Gly Val Tyr Met Arg Gly Arg Thr Asn Cys Cys Asp Asn Asp Gln 
65                  70                  75                  80  


Cys Glu Asp Gln Pro Leu Pro Gly Leu Pro Leu Ser Leu Gln Asn Gly 
                85                  90                  95      


Leu Tyr Cys Pro Gly Ala Phe Gly Ile Phe Thr Glu Asp Ser Thr Glu 
            100                 105                 110         


His Glu Val Lys Cys Arg Gly Thr Glu Thr Met Cys Leu Asp Leu Val 
        115                 120                 125             


Gly Tyr Arg Gln Glu Ser Tyr Ala Gly Asn Ile Thr Tyr Asn Ile Lys 
    130                 135                 140                 


Gly Cys Val Ser Ser Cys Pro Leu Val Thr Leu Ser Glu Arg Gly His 
145                 150                 155                 160 


Glu Gly Arg Lys Asn Asp Leu Lys Lys Val Glu Cys Arg Glu Ala Leu 
                165                 170                 175     


Lys Pro Ala Ser Ser Asp 
            180         


<210>  2
<211>  182
<212>  PRT
<213>  Python sebae

<400>  2

His Lys Cys Glu Ile Cys His Gly Phe Gly Asp Asp Cys Asp Gly Tyr 
1               5                   10                  15      


Gln Glu Glu Cys Pro Ser Pro Glu Asp Arg Cys Gly Lys Ile Leu Ile 
            20                  25                  30          


Asp Ile Ala Leu Ala Pro Val Ser Phe Arg Ala Thr His Lys Asn Cys 
        35                  40                  45              


Phe Ser Ser Ser Ile Cys Lys Leu Gly Arg Val Asp Ile His Val Trp 
    50                  55                  60                  


Glu Gly Val Tyr Ile Arg Gly Arg Thr Asn Cys Cys Asp Asn Asp Gln 
65                  70                  75                  80  


Cys Glu Asp Gln Pro Leu Pro Gly Leu Pro Leu Ser Leu Gln Asn Gly 
                85                  90                  95      


Leu Tyr Cys Pro Gly Ala Phe Gly Ile Phe Thr Glu Asp Ser Thr Glu 
            100                 105                 110         


His Glu Val Lys Cys Arg Gly Thr Glu Thr Met Cys Leu Asp Leu Val 
        115                 120                 125             


Gly Tyr Arg Gln Glu Ser Tyr Ala Gly Asn Ile Thr Tyr Asn Ile Lys 
    130                 135                 140                 


Gly Cys Val Ser Ser Cys Pro Leu Val Thr Leu Ser Glu Arg Gly His 
145                 150                 155                 160 


Glu Gly Arg Lys Asn Asp Leu Lys Lys Val Glu Cys Arg Glu Ala Leu 
                165                 170                 175     


Lys Tyr Glu Ser Ser Asp 
            180         


<210>  3
<211>  182
<212>  PRT
<213>  Python sebae

<400>  3

His Lys Cys Glu Ile Cys His Gly Phe Gly Asp Asp Cys Asp Gly Tyr 
1               5                   10                  15      


Glu Glu Glu Cys Pro Ser Pro Glu Asp Lys Cys Gly Lys Ile Leu Ile 
            20                  25                  30          


Asp Ile Ala Leu Ala Pro Val Ser Phe Arg Ala Thr His Lys Asn Cys 
        35                  40                  45              


Phe Ser Ser Ser Ile Cys Lys Leu Gly Arg Val Asp Ile His Val Trp 
    50                  55                  60                  


Asp Gly Val Tyr Met Arg Gly Arg Thr Asn Cys Cys Asp Asn Asp Gln 
65                  70                  75                  80  


Cys Glu Asp Gln Pro Leu Pro Gly Leu Pro Leu Ser Leu Lys Asn Gly 
                85                  90                  95      


Leu Tyr Cys Pro Gly Ala Phe Gly Ile Phe Thr Glu Asp Ser Thr Glu 
            100                 105                 110         


His Glu Val Lys Cys Arg Gly Thr Glu Thr Met Cys Leu Asp Leu Val 
        115                 120                 125             


Gly Tyr Arg Glu Glu Asn Tyr Ala Gly Asn Ile Thr Tyr Asn Ile Lys 
    130                 135                 140                 


Gly Cys Val Ser Ser Cys Pro Leu Leu Thr Leu Ser Glu Arg Gly His 
145                 150                 155                 160 


Glu Gly Arg Lys Asn Asp Leu Lys Lys Val Glu Cys Arg Glu Ala Leu 
                165                 170                 175     


Lys Pro Ala Ser Ser Asp 
            180         


<210>  4
<211>  182
<212>  PRT
<213>  Python sebae

<400>  4

His Lys Cys Glu Ile Cys His Gly Phe Gly Asp Asp Cys Asp Gly Tyr 
1               5                   10                  15      


Gln Glu Glu Cys Pro Ser Pro Glu Asp Lys Cys Gly Lys Ile Leu Ile 
            20                  25                  30          


Asp Ile Ala Leu Ala Pro Val Ser Phe Arg Ala Thr His Lys Asn Cys 
        35                  40                  45              


Phe Ser Ser Ser Ile Cys Lys Leu Gly Arg Val Asp Ile His Val Trp 
    50                  55                  60                  


Glu Gly Val Tyr Ile Arg Gly Arg Thr Asn Cys Cys Asp Asn Asp Gln 
65                  70                  75                  80  


Cys Glu Asp Gln Pro Leu Pro Gly Leu Pro Leu Ser Leu Lys Asn Gly 
                85                  90                  95      


Leu Tyr Cys Pro Gly Ala Phe Gly Ile Phe Thr Glu Tyr Ser Thr Glu 
            100                 105                 110         


His Glu Val Lys Cys Arg Gly Thr Glu Thr Met Cys Leu Asp Leu Val 
        115                 120                 125             


Gly Tyr Arg Glu Glu Asn Tyr Val Gly Asn Ile Thr Tyr Asn Ile Lys 
    130                 135                 140                 


Gly Cys Val Ser Ser Cys Pro Leu Val Thr Leu Ser Glu Arg Gly His 
145                 150                 155                 160 


Glu Gly Arg Lys Asn Asp Leu Lys Lys Val Glu Cys Arg Glu Ala Leu 
                165                 170                 175     


Lys Tyr Glu Ser Ser Asp 
            180         


<210>  5
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  preparate mediante tecniche di biologia molecolare a partire 
       dalla sequenza amminoacidica delle proteine denominate P3 e P4

<400>  5

His Lys Cys Glu Ile Cys His Gly Phe Gly Asp Asp Cys Asp Gly Tyr 
1               5                   10                  15      


Glu Glu Glu Cys Pro Ser Pro Glu Asp Gln Cys Gly Lys Ile Leu Ile 
            20                  25                  30          


Asp Ile Ala Leu Ala Pro Leu Ser Phe Arg Ala Thr His Lys Asn Cys 
        35                  40                  45              


Phe Ser Ser Ser Ile Cys Lys Leu Gly Arg Val Asp Ile His Val Trp 
    50                  55                  60                  


Asp Gly Val Tyr Met Arg Gly Arg Thr Asn Cys Cys Asp Asn Asp Gln 
65                  70                  75                  80  


Cys Glu Asp Glu Pro Leu Pro Gly Leu Pro Leu Ser Leu Lys Asn Gly 
                85                  90                  95      


Leu Tyr Cys Pro Gly Ala Phe Gly Ile Phe Thr Glu Asp Ser Thr Glu 
            100                 105                 110         


His Glu Val Lys Cys Arg Gly Thr Glu Thr Met Cys Leu Asp Leu Val 
        115                 120                 125             


Gly Tyr Arg Glu Glu Asn Tyr Ala Gly Asn Ile Thr Tyr Asn Ile Lys 
    130                 135                 140                 


Gly Cys Val Ser Ser Cys Pro Leu Ile Thr Leu Ser Glu Arg Gly His 
145                 150                 155                 160 


Glu Gly Arg Lys Asn Asp Leu Lys Lys Val Glu Cys Arg Glu Ala Leu 
                165                 170                 175     


Lys Pro Ala Ser Ser Asp 
            180         


<210>  6
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  preparate mediante tecniche di biologia molecolare a partire 
       dalla sequenza amminoacidica delle proteine denominate P3 e P4

<400>  6

His Lys Cys Glu Ile Cys His Gly Phe Gly Asp Asp Cys Asp Gly Tyr 
1               5                   10                  15      


Glu Glu Glu Cys Pro Ser Pro Glu Asp Gln Cys Gly Lys Ile Leu Ile 
            20                  25                  30          


Asp Ile Ala Leu Ala Pro Leu Ser Phe Arg Ala Thr His Lys Asn Cys 
        35                  40                  45              


Phe Ser Ser Ser Ile Cys Lys Leu Gly Arg Val Asp Ile His Val Trp 
    50                  55                  60                  


Glu Gly Val Tyr Ile Arg Gly Lys Thr Asn Cys Cys Asp Asn Asp Gln 
65                  70                  75                  80  


Cys Glu Asp Glu Pro Leu Pro Gly Leu Pro Leu Ser Leu Lys Asn Gly 
                85                  90                  95      


Leu Tyr Cys Pro Gly Ala Phe Gly Ile Phe Thr Glu Tyr Ser Thr Glu 
            100                 105                 110         


His Glu Val Lys Cys Arg Gly Thr Glu Thr Met Cys Leu Asp Leu Val 
        115                 120                 125             


Gly Tyr Arg Glu Glu Asn Tyr Val Gly Asn Ile Thr Tyr Asn Ile Lys 
    130                 135                 140                 


Gly Cys Val Ser Ser Cys Pro Leu Ile Thr Leu Ser Glu Arg Gly His 
145                 150                 155                 160 


Glu Gly Arg Lys Asn Asp Leu Lys Lys Val Glu Cys Arg Glu Ala Leu 
                165                 170                 175     


Lys Tyr Glu Ser Ser Asp 
            180         


<210>  7
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sintentico

<400>  7

Gly Ala Ala Thr Thr Cys Cys Ala Thr Ala Ala Ala Thr Gly Thr Gly 
1               5                   10                  15      


Ala Ala Ala Thr Thr Thr Gly Thr Cys Ala Thr Gly Gly Cys Thr Thr 
            20                  25                  30          


Thr Gly Gly 
        35  


<210>  8
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sintentico

<400>  8

Gly Cys Gly Gly Gly Cys Cys Gly Cys Thr Thr Ala Ala Thr Cys Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Thr Gly Cys Ala Gly Gly Thr Thr Thr Cys Ala 
            20                  25                  30          


Ala Gly Gly Cys Thr Thr Cys Cys Cys Thr Ala Cys Ala Thr Thr Cys 
        35                  40                  45              


<210>  9
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sintentico

<400>  9

Gly Cys Gly Gly Cys Cys Gly Cys Thr Thr Ala Ala Thr Cys Ala Gly 
1               5                   10                  15      


Ala Gly Gly Ala Thr Thr Cys Ala Thr Ala Thr Thr Thr Cys Ala Ala 
            20                  25                  30          


Gly Gly Cys Thr Thr Cys Cys Cys Thr Ala Cys Ala Thr Thr Cys 
        35                  40                  45          


