                         SEQUENCE LISTING

<110>  Athera Biotechnologies AB
 
<120>  New Antibodies

<130>  ATHBE/P51641PC

<150>  US 61/521593
<151>  2011-08-09

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of X19-A05 antibody

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Ser Gly Gly Gly Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Phe Arg Ser Val Cys Ser Asn Ala Val Cys Arg Pro 
            100                 105                 110         


Thr Ala Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of X19-A05 antibody

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Gln 
            20                  25                  30          


Ser Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Asn Ala Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  3
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of M99-B05 antibody

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Gly Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Tyr Ile Ser Pro Ser Gly Gly Gly Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Arg Phe Arg Ser Val Cys Ser Asn Gly Val Cys Arg Pro Thr 
            100                 105                 110         


Ala Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Ala Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  4
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of M99-B05 antibody

<400>  4

Gln Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr 
            20                  25                  30          


Asn Ser Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ala Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile His Trp Ala Ser Thr Arg Glu Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Asn Leu Gln Ala Glu Asp Val Ala Leu Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Tyr Phe Asn Ala Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210>  5
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of X19-A01 antibody

<400>  5

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Gly Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Tyr Ile Ser Pro Ser Gly Gly Gly Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Arg Phe Arg Ser Val Cys Ser Asn Gly Val Cys Arg Pro Thr 
            100                 105                 110         


Ala Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Ala Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of X19-A01 antibody

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Asn 
            20                  25                  30          


Ser Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile His Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Leu Gln Ala Glu Asp Val Ala Leu Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Asn Ala Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of X19-A03 antibody

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Gly Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Tyr Ile Ser Pro Ser Gly Gly Gly Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Arg Phe Arg Ser Val Cys Ser Asn Ala Val Cys Arg Pro Thr 
            100                 105                 110         


Ala Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of X19-A03 antibody

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Gln 
            20                  25                  30          


Ser Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Asn Ala Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  9
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of X19-A07 antibody

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Gly Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Tyr Ile Ser Pro Ser Gly Gly Gly Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Arg Phe Arg Ser Val Cys Ser Asn Gly Val Cys Arg Pro Thr 
            100                 105                 110         


Ala Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  10
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of X19-A07 antibody

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Asn 
            20                  25                  30          


Ser Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Asn Ala Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  11
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of X19-A09 antibody

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Ser Gly Gly Gly Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Phe Arg Ser Val Cys Ser Asn Gly Val Cys Arg Pro 
            100                 105                 110         


Thr Ala Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  12
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of X19-A09 antibody

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Asn 
            20                  25                  30          


Ser Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Asn Ala Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  13
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of X19-A11 antibody

<400>  13

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Gly Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Tyr Ile Ser Pro Ser Gly Gly Gly Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Arg Phe Arg Ser Val Ser Ser Asn Gly Val Ser Arg Pro Thr 
            100                 105                 110         


Ala Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Ala Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  14
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of the X19-A11 antibody

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Asn 
            20                  25                  30          


Ser Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile His Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Leu Gln Ala Glu Asp Val Ala Leu Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Asn Ala Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  15
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain of X19-C01 antibody

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Gly Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Tyr Ile Ser Pro Ser Gly Gly Gly Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Arg Phe Arg Ser Val Ser Ser Asn Ala Val Ser Arg Pro Thr 
            100                 105                 110         


Ala Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain of the X19-C01 antibody

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Gln 
            20                  25                  30          


Ser Asn Lys Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Asn Ala Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of the VH domain of X19-A05, M99-B05, X19-A01, X19-A03, 
       X19-A07, X19-A09, X19-A11 and X19-C01 antibodies

<400>  17

Gly Tyr Trp Met 
1               


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of the VH domain of X19-A05, M99-B05, X19-A01, X19-A03, 
       X19-A07, X19-A09, X19-A11 and X19-C01 antibodies

<400>  18

Tyr Ile Ser Pro Ser Gly Gly Gly Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH domain of X19-A05 and X19-A03 antibodies

<400>  19

Val Arg Phe Arg Ser Val Cys Ser Asn Ala Val Cys Arg Pro Thr Ala 
1               5                   10                  15      


Tyr Asp Ala Phe Asp Ile 
            20          


<210>  20
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH domain of M99-B05, X19-A01, X19-A07 and X19-A09 
       antibodies

<400>  20

Val Arg Phe Arg Ser Val Cys Ser Asn Gly Val Cys Arg Pro Thr Ala 
1               5                   10                  15      


Tyr Asp Ala Phe Asp Ile 
            20          


<210>  21
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH domain of X19-A11 antibody

<400>  21

Val Arg Phe Arg Ser Val Ser Ser Asn Gly Val Ser Arg Pro Thr Ala 
1               5                   10                  15      


Tyr Asp Ala Phe Asp Ile 
            20          


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH domain of X19-C01 antibody

<400>  22

Val Arg Phe Arg Ser Val Ser Ser Asn Ala Val Ser Arg Pro Thr Ala 
1               5                   10                  15      


Tyr Asp Ala Phe Asp Ile 
            20          


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR4 of the VL domain of X19-A05, X19-A03 and X19-C01 antibodies

<400>  23

Lys Ser Ser Gln Ser Val Phe Tyr Gln Ser Asn Lys Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR4 of the VL domain of M99-B05, X19-A01, X19-A07, X19-A09 and 
       X19-A11 antibodies

<400>  24

Lys Ser Ser Gln Ser Val Phe Tyr Asn Ser Asn Lys Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR5 of the VL domain of X19-A05, M99-B05, X19-A01, X19-A03, 
       X19-A07, X19-A09, X19-A11 and X19-C01 antibodies

<400>  25

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR6 of the VL domain of X19-A05, M99-B05, X19-A01, X19-A03, 
       X19-A07, X19-A09, X19-A11 and X19-C01 antibodies

<400>  26

Gln Gln Tyr Phe Asn Ala Pro Arg Thr 
1               5                   


<210>  27
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH region of M99-B05 antibody

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  28
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH region of X19-A05 antibody

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL region of M99-B05 and X19-A05 antibodies

<400>  29

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


