                         SEQUENCE LISTING

<110>  INOVIO PHARMACEUTICALS, INC.
 
<120>  LINEAR EXPRESSION CASSETTES AND USES THEREOF

<130>  VGX0124

<150>  US 61/513133
<151>  2011-07-29

<160>  249   

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  neuraminidase antigen  NP147

<400>  1

Thr Tyr Gln Arg Thr Arg Ala Leu Val 
1               5                   


<210>  2
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M2 antigen M2e

<400>  2

Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys 
1               5                   10                  15      


Arg Cys Asn Asp Ser Ser Asp 
            20              


<210>  3
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA H1

<400>  3
atgaaggcta tcctcgtcgt gctgctgtac accttcgcca ccgccaacgc cgataccctg       60

tgcatcggct accacgccaa caacagcacc gacaccgtgg ataccgtgct ggaaaagaac      120

gtgaccgtga cccacagcgt gaacctgctg gaagataagc acaacggcaa gctgtgcaag      180

ctgagaggcg tggcccctct gcacctgggc aagtgcaata tcgccggctg gattctgggc      240

aaccccgagt gcgagagcct gtctaccgct agctcctggt cctacatcgt ggagacaagc      300

agcagcgaca acggcacctg ttaccccggc gacttcatcg actacgagga actgcgggag      360

cagctgagca gcgtgtccag cttcgagcgg ttcgagatct tccccaagac cagctcctgg      420

cccaaccacg acagcaacaa gggcgtgacc gccgcctgtc ctcacgctgg cgccaagagc      480

ttctacaaga acctgatctg gctggtcaag aagggcaaca gctaccccaa gctgagcaag      540

agctacatca acgacaaggg caaagaggtc ctcgtcctct ggggcatcca ccaccctagc      600

accagcgccg accagcagag cctgtaccag aacgccgacg cctacgtgtt cgtgggctca      660

tctcggtaca gcaagaagtt caagcccgag atcgccatca gacccaaagt gcgggaccag      720

gaaggccgga tgaactacta ctggaccctg gtggagcccg gcgacaagat caccttcgag      780

gccaccggca atctggtggt gcccagatac gccttcgcca tggaaagaaa cgccggcagc      840

ggcatcatca tcagcgacac ccccgtgcac gactgcaaca ccacctgtca gacccccaag      900

ggcgccatca acaccagcct gcccttccag aacatccacc ccatcaccat cggcaagtgc      960

cctaagtacg tgaagtccac taagctcaga ctggccaccg gcctgagaaa cgtgcccagc     1020

atccagagca gaggcctgtt tggcgccatt gccggcttta tcgagggcgg ctggaccgga     1080

atggtggacg ggtggtacgg ctaccaccac cagaatgagc agggcagcgg ctacgccgcc     1140

gacctgaagt ccacacagaa cgccatcgac gagatcacca acaaagtgaa cagcgtgatc     1200

gagaagatga acacccagtt caccgccgtg ggcaaagagt tcaaccacct ggaaaagcgg     1260

atcgagaacc tgaacaagaa ggtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctgg tgctgctgga aaacgagcgg accctggact accacgactc caacgtgaag     1380

aatctgtacg agaaagtgcg gagccagctg aagaacaacg ccaaagagat cggcaacggc     1440

tgcttcgagt tctaccacaa gtgcgacaac acctgtatgg aaagcgtgaa gaacggcacc     1500

tacgactacc ccaagtacag cgaggaagcc aagctgaacc gggaagagat cgacggcgtg     1560

aagctggaaa gcacccggat ctaccagatc ctggccatct actctactgt ggccagctca     1620

ctggtgctgg tggtgtccct gggcgccatc tccttttgga tgtgctccaa cggcagcctg     1680

cagtgccgga tctgc                                                      1695


<210>  4
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein H1

<400>  4

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  5
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA H2

<400>  5
ggtaccaagc ttgccaccat ggccatcatc tacctgatcc tgctgttcac cgccgtgcgg       60

ggcgaccaga tctgcatcgg ctaccacgcc aacaacagca ccgagaaggt ggacaccatc      120

ctggaacgga acgtgaccgt gacccacgcc aaggacatcc tggaaaagac ccacaacggc      180

aagctgtgca agctgaacgg catccccccc ctggaactgg gcgactgcag cattgccggc      240

tggctgctgg gcaaccccga gtgcgaccgg ctgctgtccg tgcccgagtg gagctacatc      300

atggaaaaag agaacccccg ggacggcctg tgctaccccg gcagcttcaa cgactacgag      360

gaactgaagc acctgctgtc cagcgtgaag cacttcgaga aggtgaaaat cctgcccaag      420

gaccggtgga cccagcacac caccaccggc ggcagcagag cctgtgccgt gagcggcaac      480

cccagcttct tccggaacat ggtgtggctg accaagaagg gcagcaacta ccccgtggcc      540

aagggcagct acaacaacac ctccggagaa cagatgctga tcatctgggg cgtgcaccac      600

cccaacgacg agacagagca gcggaccctg taccagaacg tgggcaccta cgtgagcgtg      660

ggcaccagca ccctgaacaa gcggagcacc cccgagatcg ccacccggcc caaggtgaac      720

ggcctgggca gccggatgga attcagctgg accctgctgg acatgtggga caccatcaac      780

ttcgagagca ccggcaacct gatcgccccc gagtacggct tcaagatcag caagcggggc      840

agcagcggca tcatgaaaac cgagggcacc ctggaaaact gcgagacaaa gtgccagacc      900

cccctgggcg ccatcaacac caccctgccc ttccacaacg tgcaccccct gaccatcggc      960

gagtgcccca agtacgtgaa gagcgagaag ctggtgctgg ccaccggcct gcggaacgtg     1020

ccccagatcg agagcagggg cctgttcggc gccattgccg gattcatcga gggcggctgg     1080

cagggcatgg tggacgggtg gtacggctac caccacagca acgaccaggg cagcggctac     1140

gccgccgaca aagagagcac ccagaaggcc ttcgacggca tcaccaacaa ggtgaacagc     1200

gtgatcgaga agatgaacac ccagttcgag gccgtgggca aagagttcag caacctggaa     1260

cggcggctgg aaaacctgaa caagaaaatg gaagatggct tcctggacgt gtggacctac     1320

aacgccgagc tgctggtgct gatggaaaac gagaggaccc tggacttcca cgacagcaac     1380

gtgaagaacc tgtacgacaa agtgcggatg cagctgcggg acaacgtgaa agagctgggc     1440

aacggctgct tcgagttcta ccacaagtgc gacgacgagt gcatgaactc cgtgaagaac     1500

ggcacctacg actaccctaa gtacgaggaa gagtccaagc tgaaccggaa cgagatcaag     1560

ggcgtgaagc tgtccagcat gggcgtgtac cagatcctgg ccatctacgc caccgtggcc     1620

ggcagcctga gcctggctat tatgatggct ggcatcagct tttggatgtg cagcaacggc     1680

agcctgcagt gccggatctg catctgatga ctcgagctc                            1719


<210>  6
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein H2

<400>  6

Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Asp 
1               5                   10                  15      


Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Lys Val Asp 
            20                  25                  30          


Thr Ile Leu Glu Arg Asn Val Thr Val Thr His Ala Lys Asp Ile Leu 
        35                  40                  45              


Glu Lys Thr His Asn Gly Lys Leu Cys Lys Leu Asn Gly Ile Pro Pro 
    50                  55                  60                  


Leu Glu Leu Gly Asp Cys Ser Ile Ala Gly Trp Leu Leu Gly Asn Pro 
65                  70                  75                  80  


Glu Cys Asp Arg Leu Leu Ser Val Pro Glu Trp Ser Tyr Ile Met Glu 
                85                  90                  95      


Lys Glu Asn Pro Arg Asp Gly Leu Cys Tyr Pro Gly Ser Phe Asn Asp 
            100                 105                 110         


Tyr Glu Glu Leu Lys His Leu Leu Ser Ser Val Lys His Phe Glu Lys 
        115                 120                 125             


Val Lys Ile Leu Pro Lys Asp Arg Trp Thr Gln His Thr Thr Thr Gly 
    130                 135                 140                 


Gly Ser Arg Ala Cys Ala Val Ser Gly Asn Pro Ser Phe Phe Arg Asn 
145                 150                 155                 160 


Met Val Trp Leu Thr Lys Lys Gly Ser Asn Tyr Pro Val Ala Lys Gly 
                165                 170                 175     


Ser Tyr Asn Asn Thr Ser Gly Glu Gln Met Leu Ile Ile Trp Gly Val 
            180                 185                 190         


His His Pro Asn Asp Glu Thr Glu Gln Arg Thr Leu Tyr Gln Asn Val 
        195                 200                 205             


Gly Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Lys Arg Ser Thr 
    210                 215                 220                 


Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Leu Gly Ser Arg Met 
225                 230                 235                 240 


Glu Phe Ser Trp Thr Leu Leu Asp Met Trp Asp Thr Ile Asn Phe Glu 
                245                 250                 255     


Ser Thr Gly Asn Leu Ile Ala Pro Glu Tyr Gly Phe Lys Ile Ser Lys 
            260                 265                 270         


Arg Gly Ser Ser Gly Ile Met Lys Thr Glu Gly Thr Leu Glu Asn Cys 
        275                 280                 285             


Glu Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Thr Thr Leu Pro 
    290                 295                 300                 


Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val 
305                 310                 315                 320 


Lys Ser Glu Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Val Pro Gln 
                325                 330                 335     


Ile Glu Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
            340                 345                 350         


Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn 
        355                 360                 365             


Asp Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala 
    370                 375                 380                 


Phe Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn 
385                 390                 395                 400 


Thr Gln Phe Glu Ala Val Gly Lys Glu Phe Ser Asn Leu Glu Arg Arg 
                405                 410                 415     


Leu Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp 
            420                 425                 430         


Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu 
        435                 440                 445             


Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Met 
    450                 455                 460                 


Gln Leu Arg Asp Asn Val Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe 
465                 470                 475                 480 


Tyr His Lys Cys Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr 
                485                 490                 495     


Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu 
            500                 505                 510         


Ile Lys Gly Val Lys Leu Ser Ser Met Gly Val Tyr Gln Ile Leu Ala 
        515                 520                 525             


Ile Tyr Ala Thr Val Ala Gly Ser Leu Ser Leu Ala Ile Met Met Ala 
    530                 535                 540                 


Gly Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
545                 550                 555                 560 


Cys Ile 
        


<210>  7
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA H1 hybrid U2

<400>  7
aaggccaagc tgctggtgct gctgtgcacc ttcgccgcca ccaacgccga caccatctgc       60

atcggctacc acgccaacaa cagcaccgac accgtggata ccgtgctgga aaagaacgtg      120

accgtgaccc acagcgtgaa cctgctggaa gataagcaca acggcaagct gtgcaagctg      180

aagggaatcg cccccctgca gctgggcaag tgcaatatcg ccggctggat tctgggcaac      240

cccgagtgcg agagcctgag cagcaagagc agctggtcct acatcgtgga aacccccaac      300

agcgagaacg gcacctgtta ccccggcgac ttcgccgact acgaggaact gcgcgagcag      360

ctgagcagcg tgtccagctt cgagagattc gagatcttcc ccaagaccag cagctggccc      420

aaccacgacg tgaccaaggg cgtgaccgct agctgtagcc acgcaggcgc cagcagcttc      480

tacaagaacc tgctgtggct gaccaagaag aacggcagct accccaagct gagcaagagc      540

tacatcaaca acaaagaaaa agaggtgctg gtcctctggg gcgtccacca ccccagcaca      600

atcgccgacc agcagagcct gtaccagaac gagaacgcct acgtgtccgt gggcagcagc      660

cactacagcc ggaagttcac ccccgagatc gccaagcggc ccaaagtgcg ggaccaggaa      720

ggccggatca actactactg gaccctgctg gaacccggcg acaccatcat cttcgaggcc      780

aacggcaacc tgatcgcccc cagatacgcc ttcgccctga gcagaggctt cggcagcggc      840

atcatcatca gcaacgcccc catgcacgac tgcgacacca agtgccagac ccctcagggc      900

gccatcaaca gcagcctgcc cttccagaac atccaccccg tgaccatcgg cgagtgcccc      960

aaatacgtgc ggagcaccaa gctgcggatg gccaccggcc tgcggaacat ccccagcatc     1020

cagagcagag gcctgttcgg cgccattgcc ggcttcatcg agggcggctg gaccggaatg     1080

gtggacgggt ggtacggcta ccaccaccag aatgagcagg gcagcggcta cgccgccgac     1140

cagaagtcca cccagaacgc catcgacggc atcaccaaca aagtgaacag cgtgatcgag     1200

aagatgaaca cccagttcac cgccgtgggc aaagagttca acaagctgga aaagcggatg     1260

gaaaacctga acaagaaggt ggacgacggc ttcctggaca tctggaccta caacgccgaa     1320

ctgctcgtgc tgctggaaaa cgagcggacc ctggacttcc acgacagcaa cgtgaagaac     1380

ctgtacgaga aagtgaagtc ccagctgaag aacaacgcca aagagatcgg caacggctgc     1440

ttcgagttct accacaagtg caacaacgag tgcatggaaa gcgtgaagaa cggaacctac     1500

gactacccca agtacagcga ggaaagcaag ctgaaccggg aagagatcga cggcgtgaag     1560

ctggaatcca tgggcgtgta ccagatcctg gccatctaca gcaccgtggc tagcagcctg     1620

gtgctgctgg tgtccctggg cgccatctcc ttttggatgt gctccaacgg cagcctgcag     1680

tgccggatct gcatc                                                      1695


<210>  8
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein H1 hybrid U2

<400>  8

Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Ala Ala Thr Asn Ala 
1               5                   10                  15      


Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val 
            20                  25                  30          


Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu 
        35                  40                  45              


Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile Ala 
    50                  55                  60                  


Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly Asn 
65                  70                  75                  80  


Pro Glu Cys Glu Ser Leu Ser Ser Lys Ser Ser Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe Ala 
            100                 105                 110         


Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu 
        115                 120                 125             


Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp Val 
    130                 135                 140                 


Thr Lys Gly Val Thr Ala Ser Cys Ser His Ala Gly Ala Ser Ser Phe 
145                 150                 155                 160 


Tyr Lys Asn Leu Leu Trp Leu Thr Lys Lys Asn Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ile Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Ser Thr Ile Ala Asp Gln Gln Ser Leu Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Gly Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Ile Ser Asn Ala Pro Met 
        275                 280                 285             


His Asp Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  9
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA type B hemagluttinin

<400>  9
aaggccatca tcgtgctgct gatggtggtc acaagcaacg ccgaccggat ctgcaccggc       60

atcaccagca gcaacagccc ccacgtggtc aaaaccgcca cccagggcga agtgaacgtg      120

accggcgtga tccccctgac caccaccccc accaagagcc acttcgccaa cctgaagggc      180

accaagaccc ggggaaagct gtgccccaag tgcctgaact gcaccgacct ggacgtggcc      240

ctgggcagac ctatgtgcgt gggcaccacc cctagcgcca aggccagcat cctgcacgaa      300

gtgcggcccg tgaccagcgg ctgcttcccc atcatgcacg accggaccaa gatccggcag      360

ctccccaacc tgctgcgggg ctacgagaac atccggctga gcacccagaa cgtgatcaac      420

gccgagaagg cccctggcgg cccttacaga ctgggcacaa gcggctcttg ccccaacgcc      480

accagcaaga gcggcttttt cgccacaatg gcctgggccg tgcccaagga caacaacaag      540

accgccacca accccctgac cgtggaagtg ccctacatct gcaccgaggg cgaggaccag      600

atcaccgtgt ggggcttcca cagcgataac aagacccaga tgaagaacct gtacggcgac      660

agcaaccccc agaagttcac cagctccgcc aacggcgtga ccacccacta cgtgtcccag      720

atcggcggct tccccgacca gacagaggat ggcggcctgc cccagagcgg cagaatcgtg      780

gtggactaca tggtgcagaa gcccggcaag accggcacca tcgtgtacca gcggggcatc      840

ctgctgcccc agaaagtgtg gtgcgccagc ggccggtcca aagtgatcaa gggcagcctg      900

cctctgatcg gcgaggccga ttgcctgcac gagaagtacg gcggcctgaa caagagcaag      960

ccctactaca ccggcgagca cgccaaagcc atcggcaact gccccatctg ggtcaaaacc     1020

cccctgaagc tggccaacgg caccaagtac cggcctcccg ccaagctgct gaaagagcgg     1080

ggcttcttcg gcgctatcgc cggctttctg gaaggcggct gggagggcat gatcgccggc     1140

tggcacggct acacatctca cggcgctcat ggcgtggccg tggccgctga tctgaagtcc     1200

acccaggaag ccatcaacaa gatcaccaag aacctgaaca gcctgagcga gctggaagtg     1260

aagaatctgc agcggctgag cggcgccatg gacgagctgc acaacgagat cctggaactg     1320

gacgagaagg tggacgacct gcgggccgac accatctcca gccagatcga gctggccgtg     1380

ctgctgtcca acgagggcat catcaacagc gaggacgagc atctgctggc cctggaacgg     1440

aagctgaaga agatgctggg ccctagcgcc gtggacatcg gcaacggctg cttcgagaca     1500

aagcacaagt gcaaccagac ctgcctggac cggatcgctg ccggcacctt caacgccggc     1560

gagttcagcc tgcccacctt cgacagcctg aacatcaccg ccgccagcct gaacgacgac     1620

ggcctggaca accacaccat cctgctgtac tacagcaccg cagcctccag cctggccgtg     1680

accctgatga tcgccatctt catcgtgtac atggtgtctc gggacaacgt gtcctgcagc     1740

atctgcctg                                                             1749


<210>  10
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein type B hemagluttinin

<400>  10

Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp Arg 
1               5                   10                  15      


Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys Thr 
            20                  25                  30          


Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr Thr 
        35                  40                  45              


Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr Arg 
    50                  55                  60                  


Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val Ala 
65                  70                  75                  80  


Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala Ser 
                85                  90                  95      


Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile Met 
            100                 105                 110         


His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly Tyr 
        115                 120                 125             


Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asn Ala Glu Lys Ala 
    130                 135                 140                 


Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn Ala 
145                 150                 155                 160 


Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro Lys 
                165                 170                 175     


Asp Asn Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
            180                 185                 190         


Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
        195                 200                 205             


Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln 
    210                 215                 220                 


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
225                 230                 235                 240 


Ile Gly Gly Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser 
                245                 250                 255     


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
            260                 265                 270         


Thr Ile Val Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys 
        275                 280                 285             


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
    290                 295                 300                 


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
305                 310                 315                 320 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
                325                 330                 335     


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
            340                 345                 350         


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
        355                 360                 365             


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
    370                 375                 380                 


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
385                 390                 395                 400 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
                405                 410                 415     


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
            420                 425                 430         


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
        435                 440                 445             


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    450                 455                 460                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
465                 470                 475                 480 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
                485                 490                 495     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            500                 505                 510         


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        515                 520                 525             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
    530                 535                 540                 


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
545                 550                 555                 560 


Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn 
                565                 570                 575     


Val Ser Cys Ser Ile Cys Leu 
            580             


<210>  11
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype A consensus Envelope DNA sequence construct

<400>  11
ggatccatgg actggacctg gattctgttc ctggtggccg ccgccaccag agtgcacagc       60

agagtgatgg gcatccagcg gaattgccag cacctgtgga gatggggcac catgatcctg      120

ggcatgatca tcatctgctc tgccgccgag aacctgtggg tgaccgtgta ctacggcgtg      180

cctgtgtgga aggacgccga gaccaccctg ttctgcgcca gcgacgccaa ggcctacgat      240

accgaagtgc acaatgtgtg ggccacccac gcctgcgtgc ctaccgatcc caacccccag      300

gagatcaacc tggagaacgt gaccgaggag ttcaacatgt ggaagaacaa catggtggag      360

cagatgcaca ccgacatcat cagcctgtgg gaccagagcc tgaagccttg cgtgaagctg      420

acccctctgt gcgtgaccct gaactgcagc aacgtgaacg tgaccaccaa catcatgaag      480

ggcgagatca agaactgcag cttcaacatg accaccgagc tgcgggacaa gaagcagaaa      540

gtgtacagcc tgttctacaa gctggacgtg gtgcagatca acaagagcaa cagcagcagc      600

cagtaccggc tgatcaactg caacaccagc gccatcaccc aggcctgccc caaagtgagc      660

ttcgagccca tccccatcca ctactgcgcc cctgccggct tcgccatcct gaagtgcaag      720

gacaaggagt ttaacggcac cggcccctgc aagaatgtga gcaccgtgca gtgcacccac      780

ggcatcaagc ccgtggtgtc cacccagctg ctgctgaacg gcagcctggc cgaggaggaa      840

gtgatgatcc ggagcgagaa catcaccaac aacgccaaga acatcatcgt gcagctgacc      900

aagcccgtga agatcaattg cacccggccc aacaacaaca cccggaagag catcagaatc      960

ggccctggcc aggccttcta cgccaccggc gacatcatcg gcgatatcag gcaggcccac     1020

tgcaatgtga gccggaccga gtggaacgag accctgcaga aagtggccaa gcagctgcgg     1080

aagtacttca acaacaagac catcatcttc accaacagca gcggcggcag actgagaatc     1140

accacccaca gcttcaattg tggcggcgag ttcttctact gcaatacctc cggcctgttc     1200

aacagcacct ggaacggcaa cggcaccaag aagaagaaca gcaccgagag caacgacacc     1260

atcaccctgc cctgccggat caagcagatc atcaatatgt ggcagagggt gggccaggcc     1320

atgtacgccc ctcccatcca gggcgtgatc agatgcgaga gcaacatcac cggcctgctg     1380

ctgaccagag atggcggcga caacaacagc aagaacgaga ccttcagacc tggcggcgga     1440

gacatgaggg acaactggcg gagcgagctg tacaagtaca aagtggtgaa gatcgagccc     1500

ctgggcgtgg cccccaccaa ggccaagaga agagtggtgg agcgggagaa gagagctgtg     1560

ggcatcggcg ccgtgttcct gggcttcctg ggagccgccg gaagcaccat gggagccgcc     1620

agcatcaccc tgaccgtgca ggccagacag ctgctgagcg gcattgtgca gcagcagagc     1680

aacctgctga gagccatcga ggcccagcag cacctgctga agctgacagt gtggggcatc     1740

aaacagctgc aggcccgcgt gctggccgtg gagagatacc tgaaggacca gcagctgctg     1800

ggcatctggg gctgcagcgg caagctgatc tgcaccacca acgtgccctg gaatagcagc     1860

tggagcaaca agagccagag cgagatctgg gacaacatga cctggctgca gtgggacaag     1920

gagatcagca actacaccga tatcatctac aacctgatcg aggagagcca gaaccagcag     1980

gagaagaacg agcaggatct gctggccctg gacaagtggg ccaacctgtg gaactggttc     2040

gacatcagca actggctgtg gtacatcaag atcttcatca tgattgtggg cggcctgatc     2100

ggcctgagaa tcgtgttcgc cgtgctgtct gtgtgactcg ag                        2142


<210>  12
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype A consensus Envelope protein sequence construct

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Met Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg 
            20                  25                  30          


Trp Gly Thr Met Ile Leu Gly Met Ile Ile Ile Cys Ser Ala Ala Glu 
        35                  40                  45              


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala 
    50                  55                  60                  


Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
65                  70                  75                  80  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Ile Asn Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Ser Asn Val Asn Val Thr Thr Asn Ile Met Lys Gly Glu 
145                 150                 155                 160 


Ile Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys 
                165                 170                 175     


Gln Lys Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Gln Ile Asn 
            180                 185                 190         


Lys Ser Asn Ser Ser Ser Gln Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys 
225                 230                 235                 240 


Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu Asn Ile Thr Asn 
        275                 280                 285             


Asn Ala Lys Asn Ile Ile Val Gln Leu Thr Lys Pro Val Lys Ile Asn 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Val Ser Arg Thr Glu Trp Asn Glu Thr Leu Gln Lys 
            340                 345                 350         


Val Ala Lys Gln Leu Arg Lys Tyr Phe Asn Asn Lys Thr Ile Ile Phe 
        355                 360                 365             


Thr Asn Ser Ser Gly Gly Arg Leu Arg Ile Thr Thr His Ser Phe Asn 
    370                 375                 380                 


Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser 
385                 390                 395                 400 


Thr Trp Asn Gly Asn Gly Thr Lys Lys Lys Asn Ser Thr Glu Ser Asn 
                405                 410                 415     


Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
            420                 425                 430         


Gln Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile 
        435                 440                 445             


Arg Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
    450                 455                 460                 


Asp Asn Asn Ser Lys Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu 
            500                 505                 510         


Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln 
    610                 615                 620                 


Ser Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile 
625                 630                 635                 640 


Ser Asn Tyr Thr Asp Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala 
            660                 665                 670         


Asn Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
        675                 680                 685             


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
    690                 695                 700                 


Ala Val Leu Ser Val 
705                 


<210>  13
<211>  2734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Envelope DNA sequence construct

<400>  13
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgccgc caccagagtg       60

cacagcagag tgaagggcat ccggaagaac taccagcacc tgtggagatg gggcaccatg      120

ctgctgggca tgctgatgat ctgttctgcc gccgagaagc tgtgggtgac cgtgtactac      180

ggcgtgcctg tgtggaagga ggccaccacc accctgttct gcgccagcga cgccaaggcc      240

tacgataccg aagtgcacaa tgtgtgggcc acccacgcct gcgtgcctac cgatcccaac      300

cctcaggaag tggtgctgga gaacgtgacc gagaacttca acatgtggaa gaacaacatg      360

gtggagcaga tgcacgagga catcatcagc ctgtgggacc agagcctgaa gccttgcgtg      420

aagctgaccc ctctgtgcgt gaccctgaac tgcaccgacc tgagcggcga gaagatggag      480

aagggcgaga tcaagaactg cagcttcaac atcaccacct ccatccggga caaagtgcag      540

aaggagtacg ccctgttcta caagctggac gtggtgccca tcgacaacga caacaccagc      600

taccggctga tcagctgcaa caccagcgtg atcacccagg cctgccccaa agtgagcttc      660

gagcccatcc ccatccacta ctgcgcccct gccggcttcg ccatcctgaa gtgcaacgac      720

aagaagttca acggcaccgg cccttgcacc aatgtgagca ccgtgcagtg cacccacggc      780

atcagacccg tggtgtccac ccagctgctg ctgaacggca gcctggccga ggaagaagtg      840

gtgatccgga gcgagaattt caccaacaac gccaagacca tcatcgtgca gctgaacgag      900

agcgtggaga tcaactgcac ccggcccaac aacaataccc ggaagagcat ccacatcggc      960

cctggccagg ccttctacac caccggcgag atcatcggcg atatcaggca ggcccactgc     1020

aatatcagcc gggccaagtg gaacaacacc ctgaagcaga tcgtgaagaa gctgcgggag     1080

cagttcggca acaagaccat cgtgttcaac cagagcagcg gcggcagacc tagaatcgtg     1140

atgcacagct tcaactgtgg cggcgagttc ttctactgca acacaaccca gctgttcaac     1200

agcacctgga acgtgaacgg gacctggaac aacaacaccg agggcaacga caccatcacc     1260

ctgccctgcc ggatcaagca gatcatcaat atgtggcagg aggtgggcaa ggccatgtac     1320

gcccctccca tcagaggcca gatccggtgc agcagcaata tcaccggcct gctgctgacc     1380

agagatggcg gcaacaataa caccaacgag accgagatct ttagacctgg cggcggagac     1440

atgagggaca actggcggag cgagctgtac aagtacaaag tggtgaagat cgagcccctg     1500

ggcgtggccc ccaccaaggc caagagaaga gtggtgcagc gggagaagag agctgtgggc     1560

atcggcgcca tgtttctggg ctttctggga gccgccggaa gcaccatggg agccgccagc     1620

atgaccctga ccgtgcaggc cagacagctg ctgagcggca tcgtgcagca gcagaacaac     1680

ctgctgagag ccatcgaggc ccagcagcac ctgctgcagc tgacagtgtg gggcatcaag     1740

cagctgcagg cccgcgtgct ggccgtggag agatacctga aggaccagca gctgctggga     1800

atctggggct gcagcggcaa gctgatctgc accaccaccg tgccctggaa cgccagctgg     1860

agcaacaaga gcctggacga gatctgggac aacatgacct ggatggagtg ggagcgggag     1920

atcgacaact acaccagcct gatctacacc ctgatcgagg agagccagaa ccagcaggag     1980

aagaacgagc aggagctgct ggagctggac aagtgggcca gcctgtggaa ctggttcgac     2040

atcaccaact ggctgtggta catcaagatc ttcatcatga ttgtgggcgg cctgatcggc     2100

ctgagaatcg tgttcgccgt gctgagcatc tacccctacg acgtgcccga ttacgcctga     2160

gaattcgtaa gtaagtgtca tatgggagag ctcgactaga ctggacagcc aatgacgggt     2220

aagagagtga catttctcac taacctaaga caggagggcc gtcaaagcta ctgcctaatc     2280

caatgacggg taatagtgac aagaaatgta tcactccaac ctaagacagg cgcagcctcc     2340

gagggatgtg tcttttgttt tttataatta aaaagggtga catgtccgga gccgtgctgc     2400

ccggatgatg tcttggcctc tgtttgctac cggtatcgat gttaacgtcg accccgggct     2460

cgaggtaagt aagtgtcata tgggagagct cgactagact ggacagccaa tgacgggtaa     2520

gagagtgaca tttctcacta acctaagaca ggagggccgt caaagctact gcctaatcca     2580

atgacgggta atagtgacaa gaaatgtatc actccaacct aagacaggcg cagcctccga     2640

gggatgtgtc ttttgttttt tataattaaa aagggtgaca tgtccggagc cgtgctgccc     2700

ggatgatgtc ttggcctctg tttgctgcgg ccgc                                 2734


<210>  14
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Envelope protein sequence construct

<400>  14

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg 
            20                  25                  30          


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu 
        35                  40                  45              


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
    50                  55                  60                  


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
65                  70                  75                  80  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Thr Asp Leu Ser Gly Glu Lys Met Glu Lys Gly Glu Ile 
145                 150                 155                 160 


Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser Ile Arg Asp Lys Val Gln 
                165                 170                 175     


Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn 
            180                 185                 190         


Asp Asn Thr Ser Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
        275                 280                 285             


Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Gln Ala 
305                 310                 315                 320 


Phe Tyr Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
                325                 330                 335     


Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Lys 
            340                 345                 350         


Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser 
        355                 360                 365             


Ser Gly Gly Arg Pro Arg Ile Val Met His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn 
385                 390                 395                 400 


Val Asn Gly Thr Trp Asn Asn Asn Thr Glu Gly Asn Asp Thr Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Thr 
    450                 455                 460                 


Asn Glu Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu 
                485                 490                 495     


Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys 
            500                 505                 510         


Arg Ala Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala 
        515                 520                 525             


Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg 
    530                 535                 540                 


Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala 
545                 550                 555                 560 


Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys 
                565                 570                 575     


Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 
            580                 585                 590         


Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr 
        595                 600                 605             


Thr Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp Glu Ile 
    610                 615                 620                 


Trp Asp Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr 
625                 630                 635                 640 


Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 
                645                 650                 655     


Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
            660                 665                 670         


Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile 
        675                 680                 685             


Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu 
    690                 695                 700                 


Ser Ile Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
705                 710                 715 


<210>  15
<211>  2140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype C consensus Envelope DNA sequence construct

<400>  15
ggatccgcca ccatggattg gacctggatt ctgttcctgg tggccgccgc cacaagagtg       60

cacagcagag tgcggggcat cctgagaaat tgccagcagt ggtggatctg gggcattctg      120

gggttctgga tgctgatgat ctgcaacgtg atgggcaacc tgtgggtgac cgtgtactac      180

ggcgtgcctg tgtggaagga ggccaagacc accctgttct gtgccagcga tgccaaggcc      240

tacgagaccg aggtgcacaa tgtgtgggcc acccacgcct gtgtgcccac cgatcccaac      300

cctcaggaga tggtgctgga gaacgtgacc gagaacttca acatgtggaa gaacgacatg      360

gtggaccaga tgcacgagga catcatcagc ctgtgggacc agagcctgaa gccttgcgtg      420

aagctgaccc ctctgtgcgt gaccctgaac tgccggaaca acgtgaacaa caacaacacc      480

atgaaggagg agatcaagaa ctgcagcttc aacatcacca ccgagctgcg ggacaagaag      540

cagaaggtgt acgccctgtt ctaccggctg gacatcgtgc ccctgaacga gaagaacaac      600

agcaacgact accggctgat caactgcaac accagcgcca tcacccaggc ctgtcccaag      660

gtgtccttcg accccatccc catccactat tgtgcccctg ccggctacgc catcctgaag      720

tgcaacaaca agaccttcaa cggcaccggc ccctgcaata atgtgagcac cgtgcagtgt      780

acccacggca tcaagcctgt ggtgtccacc cagctgctgc tgaatggcag cctggccgag      840

gaggagatta tcatccggag cgagaacctg accaacaacg ccaagaccat cattgtgcac      900

ctgaatgaga gcgtggagat cgtgtgtacc cggcccaaca acaatacccg gaagagcatc      960

agaatcggcc ctggccagac cttttacgcc accggcgaca tcatcggcga tatcaggcag     1020

gcccactgca atatcagcga ggagaagtgg aacaagaccc tgcagcgggt gtccgagaag     1080

ctgaaggagc acttccccaa taagaccatc aagttcgccc ctagcagcgg cggcagactg     1140

gagatcacca cccacagctt caactgcagg ggcgagttct tctactgcaa taccagcaag     1200

ctgttcaaca gcacctacat gcccaacagc accaacaata ccaacaccac catcaccctg     1260

ccctgccgga tcaagcagat catcaatatg tggcaggaag tgggcagagc catgtacgcc     1320

cctcccatcg agggcaacat cacctgcaag tccaacatca ccggcctgct gctgacaaga     1380

gatggcggca agaacgacac caatgacacc gagaccttca gacctggcgg cggagacatg     1440

agggacaact ggcggagcga gctgtacaag tacaaggtgg tggagatcaa gcctctgggc     1500

gtggccccta ccaaggccaa gaggagagtg gtggagaggg agaagagagc cgtgggcatc     1560

ggcgccgtgt ttctgggctt tctgggagcc gccggatcta caatgggagc cgccagcatc     1620

acactgaccg tgcaggccag acagctgctg agcggcatcg tgcagcagca gagcaatctg     1680

ctgagagcca tcgaggccca gcagcacatg ctgcagctga cagtgtgggg catcaagcag     1740

ctgcagacca gagtgctggc catcgagcgc tacctgaagg atcagcagct gctgggcatc     1800

tggggctgta gcggcaagct gatctgtacc accgccgtgc cttggaatag cagctggagc     1860

aacaagagcc aggaggacat ctgggacaac atgacctgga tgcagtggga ccgggagatc     1920

agcaactaca ccgacaccat ctacaggctg ctggaggaca gccagaacca gcaggagaag     1980

aacgagaagg acctgctggc cctggacagc tggaagaacc tgtggaactg gttcgacatc     2040

accaactggc tgtggtacat caagatcttc atcatgattg tgggcggcct gatcggcctg     2100

agaatcatct tcgccgtgct gagcatctga tagcggccgc                           2140


<210>  16
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype C consensus Envelope protein sequence construct

<400>  16

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Arg Gly Ile Leu Arg Asn Cys Gln Gln Trp Trp Ile 
            20                  25                  30          


Trp Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Met Gly 
        35                  40                  45              


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
    50                  55                  60                  


Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu 
65                  70                  75                  80  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Arg Asn Asn Val Asn Asn Asn Asn Thr Met Lys Glu Glu 
145                 150                 155                 160 


Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu Arg Asp Lys Lys 
                165                 170                 175     


Gln Lys Val Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asn 
            180                 185                 190         


Glu Lys Asn Asn Ser Asn Asp Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
225                 230                 235                 240 


Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn 
        275                 280                 285             


Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Val 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Ile Ser Glu Glu Lys Trp Asn Lys Thr Leu Gln Arg 
            340                 345                 350         


Val Ser Glu Lys Leu Lys Glu His Phe Pro Asn Lys Thr Ile Lys Phe 
        355                 360                 365             


Ala Pro Ser Ser Gly Gly Arg Leu Glu Ile Thr Thr His Ser Phe Asn 
    370                 375                 380                 


Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Phe Asn Ser 
385                 390                 395                 400 


Thr Tyr Met Pro Asn Ser Thr Asn Asn Thr Asn Thr Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Asn Asp Thr Asn 
    450                 455                 460                 


Asp Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly 
                485                 490                 495     


Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg 
            500                 505                 510         


Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly 
        515                 520                 525             


Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln 
    530                 535                 540                 


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
545                 550                 555                 560 


Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
                565                 570                 575     


Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln 
            580                 585                 590         


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala 
        595                 600                 605             


Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp 
    610                 615                 620                 


Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr 
625                 630                 635                 640 


Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys 
                645                 650                 655     


Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn 
            660                 665                 670         


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
        675                 680                 685             


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser 
    690                 695                 700                 


Ile 
705 


<210>  17
<211>  2089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype D consensus Envelope DNA sequence construct

<400>  17
gggcatcaag cggaattacc agcacctgtg gaagtggggc accatgctgc tgggcatgct       60

gatgacctgc agcgtggccg agaacctgtg ggtgaccgtg tactacggcg tgcctgtgtg      120

gaaggaagcc accaccaccc tgttctgcgc cagcgatgcc aagagctaca agaccgaggc      180

ccacaatatc tgggccaccc acgcctgcgt gcctaccgat cccaaccctc aggagatcga      240

gctggagaac gtgaccgaga acttcaacat gtggaagaac aacatggtgg agcagatgca      300

cgaggacatc atcagcctgt gggaccagag cctgaagcct tgcgtgaagc tgacccctct      360

gtgcgtgacc ctgaactgca ccgacggcat gaggaacgac accaacgata ccaacgtgac      420

catggaggag ggcgagatga agaactgcag cttcaacatc accaccgaag tgcgggacaa      480

gaagaagcag gtgcacgccc tgttctacaa gctggacgtg gtgcccatcg acgacaacaa      540

caccaacaac agcaactacc ggctgatcaa ctgcaacacc agcgccatca cccaggcctg      600

ccccaaagtg accttcgagc ccatccccat ccactactgc gcccctgccg gcttcgccat      660

cctgaagtgc aaggataaga agttcaacgg caccggcccc tgcaagaatg tgagcaccgt      720

gcagtgcacc cacggcatca gacccgtggt gtccacccag ctgctgctga acggcagcct      780

ggccgaggag gagatcatca tccggagcga gaacctgacc aacaacgcca agatcatcat      840

tgtgcagctg aacgagagcg tgaccatcaa ttgcacccgg ccctacaaca atacccggaa      900

gcgcatcccc atcggcctgg gccaggcctt ctacaccacc agaggcatca tcggcgacat      960

cagacaggcc cactgcaata tcagcggagc cgagtggaat aagaccctgc agcaggtggc     1020

caagaagctg ggcgacctgc tgaacaagac caccatcatc ttcaagccta gcagcggcgg     1080

cagacctaga atcaccaccc acagcttcaa ttgtggcggc gagttcttct actgcaatac     1140

cagccggctg ttcaacagca cctggagcaa gaacagcacc agcaactcca ccaaggagaa     1200

caacaccatc accctgccct gccggatcaa gcagatcatc aatatgtggc agggagtggg     1260

caaggccatg tacgcccctc ccatcgaggg cctgatcaag tgcagcagca acatcaccgg     1320

cctgctgctg accagagatg gcggagccaa caactcccac aacgagacct tcagacctgg     1380

cggcggagac atgagggaca actggcggag cgagctgtac aagtacaaag tggtgaagat     1440

cgagcccctg ggcgtggccc ccaccagagc caagagaaga gtggtggagc gggagaagag     1500

agccatcgga ctgggcgcca tgttcctggg cttcctggga gccgccggaa gcaccatggg     1560

agccgccagc ctgaccctga ccgtgcaggc cagacagctg ctgagcggca tcgtgcagca     1620

gcagaacaac ctgctgagag ccattgaggc ccagcagcac ctgctgcagc tgacagtgtg     1680

gggcattaag cagctgcagg ccaggattct ggccgtggag cgctacctga aggatcagca     1740

gctgctggga atctggggct gcagcggcaa gcacatctgc accaccaccg tgccttggaa     1800

tagcagctgg agcaacaaga gcctggacga gatctggaac aacatgacct ggatggagtg     1860

ggagagggag atcgacaact acaccggcct gatctacagc ctgatcgagg agagccagac     1920

ccagcaggag aagaacgagc aggagctgct ggagctggac aagtgggcca gcctgtggaa     1980

ctggttcagc atcacccagt ggctgtggta catcaagatc ttcatcatga ttgtgggcgg     2040

cctgatcggc ctgagaatcg tgttcgccgt gctgagcctg tgactcgag                 2089


<210>  18
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype D consensus Envelope protein sequence construct

<400>  18

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Arg Gly Ile Lys Arg Asn Tyr Gln His Leu Trp Lys 
            20                  25                  30          


Trp Gly Thr Met Leu Leu Gly Met Leu Met Thr Cys Ser Val Ala Glu 
        35                  40                  45              


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
    50                  55                  60                  


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Lys Thr Glu 
65                  70                  75                  80  


Ala His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Ile Glu Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Thr Asp Gly Met Arg Asn Asp Thr Asn Asp Thr Asn Val 
145                 150                 155                 160 


Thr Met Glu Glu Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr 
                165                 170                 175     


Glu Val Arg Asp Lys Lys Lys Gln Val His Ala Leu Phe Tyr Lys Leu 
            180                 185                 190         


Asp Val Val Pro Ile Asp Asp Asn Asn Thr Asn Asn Ser Asn Tyr Arg 
        195                 200                 205             


Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val 
    210                 215                 220                 


Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
225                 230                 235                 240 


Ile Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys 
                245                 250                 255     


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
            260                 265                 270         


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile 
        275                 280                 285             


Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu 
    290                 295                 300                 


Asn Glu Ser Val Thr Ile Asn Cys Thr Arg Pro Tyr Asn Asn Thr Arg 
305                 310                 315                 320 


Lys Arg Ile Pro Ile Gly Leu Gly Gln Ala Phe Tyr Thr Thr Arg Gly 
                325                 330                 335     


Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gly Ala Glu 
            340                 345                 350         


Trp Asn Lys Thr Leu Gln Gln Val Ala Lys Lys Leu Gly Asp Leu Leu 
        355                 360                 365             


Asn Lys Thr Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Arg Pro Arg 
    370                 375                 380                 


Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
385                 390                 395                 400 


Thr Ser Arg Leu Phe Asn Ser Thr Trp Ser Lys Asn Ser Thr Ser Asn 
                405                 410                 415     


Ser Thr Lys Glu Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln 
            420                 425                 430         


Ile Ile Asn Met Trp Gln Gly Val Gly Lys Ala Met Tyr Ala Pro Pro 
        435                 440                 445             


Ile Glu Gly Leu Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
    450                 455                 460                 


Thr Arg Asp Gly Gly Ala Asn Asn Ser His Asn Glu Thr Phe Arg Pro 
465                 470                 475                 480 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
                485                 490                 495     


Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys 
            500                 505                 510         


Arg Arg Val Val Glu Arg Glu Lys Arg Ala Ile Gly Leu Gly Ala Met 
        515                 520                 525             


Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser 
    530                 535                 540                 


Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 
545                 550                 555                 560 


Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 
                565                 570                 575     


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala 
            580                 585                 590         


Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys 
        595                 600                 605             


Ser Gly Lys His Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp 
    610                 615                 620                 


Ser Asn Lys Ser Leu Asp Glu Ile Trp Asn Asn Met Thr Trp Met Glu 
625                 630                 635                 640 


Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Ile 
                645                 650                 655     


Glu Glu Ser Gln Thr Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 
            660                 665                 670         


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Ser Ile Thr Gln Trp 
        675                 680                 685             


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly 
    690                 695                 700                 


Leu Arg Ile Val Phe Ala Val Leu Ser Leu 
705                 710                 


<210>  19
<211>  1049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Nef-Rev DNA sequence construct

<400>  19
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgctgc caccagagtg       60

cacagcagca agagaagcgt ggtgggttgg cctacagtgc gggagaggat gagaagagcc      120

gagcctgccg ccgatggagt gggcgccgtg tctagagatc tggagaagca cggcgccatc      180

accagcagca ataccgccgc caacaatgcc gactgcgcct ggctggaggc ccaggaggag      240

gaggaagtgg gcttccctgt gagagcccag gtggccctga gagccatgac ctacaaggcc      300

gccgtggatc tgagccactt cctgaaggag aagggcggcc tggagggcct gatctacagc      360

cagaagcggc aggacatcct ggatctgtgg gtgtaccaca cccagggcta cttccccgac      420

tggcagaatt acacccctgg ccctggcatc agataccctc tgaccttcgg ctggtgcttc      480

aagctggtgc ctgtggagcc tgagaaagtg gaggaggcca acgagggcga gaacaattct      540

gccgcccacc ctatgagcct gcacggcatg gacgatcccg agagggaagt gctggtgtgg      600

aagttcgaca gcaggctggc cttccaccac atggccagag agctgcaccc cgagtactac      660

aaggactgcc ggggcaggaa gagaagaagc gccggcagaa gcggcgacag cgacgaggag      720

ctgctgaaaa cagtgcggct gatcaagttc ctgtaccaga gcaaccctcc tcccagcccc      780

gagggcacca gacaggcccg gagaaaccgg aggaggcggt ggagagagag gcagcggcag      840

atcagaagca tcagcgagtg gattctgagc acctacctgg gcagacccgc cgagcccgtg      900

cccctgcagc tgccccccct ggagagactg accctggact gcaacgagga ctgcggcacc      960

agcggcaccc agggagtggg cagcccccag atcctggtgg agagccctgc cgtgctggag     1020

agcggcacca aggagtgatg agcggccgc                                       1049


<210>  20
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Nef-Rev protein sequence construct

<400>  20

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Lys Arg Ser Val Val Gly Trp Pro Thr Val Arg Glu Arg 
            20                  25                  30          


Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala Val Ser Arg 
        35                  40                  45              


Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr Ala Ala Asn 
    50                  55                  60                  


Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly 
65                  70                  75                  80  


Phe Pro Val Arg Ala Gln Val Ala Leu Arg Ala Met Thr Tyr Lys Ala 
                85                  90                  95      


Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu Glu Gly 
            100                 105                 110         


Leu Ile Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu Trp Val Tyr 
        115                 120                 125             


His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro 
    130                 135                 140                 


Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val Pro 
145                 150                 155                 160 


Val Glu Pro Glu Lys Val Glu Glu Ala Asn Glu Gly Glu Asn Asn Ser 
                165                 170                 175     


Ala Ala His Pro Met Ser Leu His Gly Met Asp Asp Pro Glu Arg Glu 
            180                 185                 190         


Val Leu Val Trp Lys Phe Asp Ser Arg Leu Ala Phe His His Met Ala 
        195                 200                 205             


Arg Glu Leu His Pro Glu Tyr Tyr Lys Asp Cys Arg Gly Arg Lys Arg 
    210                 215                 220                 


Arg Ser Ala Gly Arg Ser Gly Asp Ser Asp Glu Glu Leu Leu Lys Thr 
225                 230                 235                 240 


Val Arg Leu Ile Lys Phe Leu Tyr Gln Ser Asn Pro Pro Pro Ser Pro 
                245                 250                 255     


Glu Gly Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu 
            260                 265                 270         


Arg Gln Arg Gln Ile Arg Ser Ile Ser Glu Trp Ile Leu Ser Thr Tyr 
        275                 280                 285             


Leu Gly Arg Pro Ala Glu Pro Val Pro Leu Gln Leu Pro Pro Leu Glu 
    290                 295                 300                 


Arg Leu Thr Leu Asp Cys Asn Glu Asp Cys Gly Thr Ser Gly Thr Gln 
305                 310                 315                 320 


Gly Val Gly Ser Pro Gln Ile Leu Val Glu Ser Pro Ala Val Leu Glu 
                325                 330                 335     


Ser Gly Thr Lys Glu 
            340     


<210>  21
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gag consensus DNA sequence of subtype A, B, C and D construct

<400>  21
ggatccgcca ccatggactg gacctggatt ctgtttctgg tcgccgccgc cacaagagtg       60

cacagcggcg ccagagccag cgtgctgtcc ggcggcaagc tggacgcctg ggagaagatc      120

agactgaggc ctggcggcaa gaagaagtac cggctgaagc accttgtgtg ggccagcaga      180

gagctggaga gattcgccct gaatcctggc ctgctggaga ccagcgaggg ctgtaagcag      240

atcatcggcc agctgcagcc cgccctgcag accggcagcg aggagctgag aagcctgtac      300

aacaccgtgg ccaccctgta ctgcgtgcac gagaagatcg aggtgaagga caccaaggag      360

gccctggaca agatcgagga ggagcagaac aagagcaagc agaaggccca gcaggccgcc      420

gccgacaccg gcaacagcag ccaggtgtcc cagaactacc ccatcgtgca gaatctgcag      480

ggccagatgg tgcaccaggc catcagcccc agaaccctga atgcctgggt gaaggtgatc      540

gaggagaagg ccttcagccc tgaggtgatc cctatgttca gcgccctgag cgagggcgcc      600

acacctcagg acctgaacac catgctgaac acagtggggg gccaccaggc cgccatgcag      660

atgctgaagg ataccatcaa cgaggaggcc gccgagtggg acagactgca ccccgtgcac      720

gccggaccta tcgcccctgg ccagatgaga gagcccagag gcagcgacat cgccggcacc      780

acctccaccc tgcaagagca gatcggctgg atgaccagca acccccccat ccctgtgggc      840

gacatctaca agcggtggat catcctgggc ctgaacaaga ttgtgaggat gtacagcccc      900

gtgtccatcc tggatatcag gcagggcccc aaggagccct tcagagacta cgtggaccgg      960

ttcttcaaga ccctgagagc cgagcaggcc agccaggacg tgaagaactg gatgaccgag     1020

accctgctgg tgcagaacgc caaccccgac tgtaagacca tcctgagagc cctgggccct     1080

ggcgccaccc tggaggagat gatgaccgcc tgccagggag tgggcggacc cggccacaag     1140

gccagagtgc tggccgaggc catgagccag gccaccaaca gcaacatcat gatgcagcgg     1200

ggcaacttca gaggccccag gaggatcgtg aagtgcttca actgtggcaa ggagggccac     1260

atcgccagaa actgtagggc ccccaggaag aagggctgct ggaagtgtgg caaagagggg     1320

caccagatga aggactgtac cgagcggcag gccaatttcc tggggaagat ctggcccagc     1380

cacaagggca gacccggcaa tttcctgcag agcagacctg agcccaccgc ccctcccgcc     1440

gagagcttcg gcttcggcga ggagatcacc cccagcccca agcaggagcc caaggacaga     1500

gagctgtacc ctctggccag cctgaagagc ctgttcggca acgatcccct gagccagtac     1560

ccctacgacg tgcccgatta cgcctgagaa ttcgtaagta agtgtcatat gggagagctc     1620

gactagactg gacagccaat gacgggtaag agagtgacat ttctcactaa cctaagacag     1680

gagggccgtc aaagctactg cctaatccaa tgacgggtaa tagtgacaag aaatgtatca     1740

ctccaaccta agacaggcgc agcctccgag ggatgtgtct tttgtttttt ataattaaaa     1800

agggtgacat gtccggagcc gtgctgcccg gatgatgtct tggcctctgt ttgctgcggc     1860

cgc                                                                   1863


<210>  22
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gag consensus protein sequence of subtype A, B, C and D construct

<400>  22

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala 
            20                  25                  30          


Trp Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu 
        35                  40                  45              


Lys His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn 
    50                  55                  60                  


Pro Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Gly Gln 
65                  70                  75                  80  


Leu Gln Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr 
                85                  90                  95      


Asn Thr Val Ala Thr Leu Tyr Cys Val His Glu Lys Ile Glu Val Lys 
            100                 105                 110         


Asp Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser 
        115                 120                 125             


Lys Gln Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln 
    130                 135                 140                 


Val Ser Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val 
145                 150                 155                 160 


His Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile 
                165                 170                 175     


Glu Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu 
            180                 185                 190         


Ser Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val 
        195                 200                 205             


Gly Gly His Gln Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu 
    210                 215                 220                 


Glu Ala Ala Glu Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile 
225                 230                 235                 240 


Ala Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr 
                245                 250                 255     


Thr Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Ser Asn Pro Pro 
            260                 265                 270         


Ile Pro Val Gly Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn 
        275                 280                 285             


Lys Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln 
    290                 295                 300                 


Gly Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr 
305                 310                 315                 320 


Leu Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu 
                325                 330                 335     


Thr Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg 
            340                 345                 350         


Ala Leu Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln 
        355                 360                 365             


Gly Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met 
    370                 375                 380                 


Ser Gln Ala Thr Asn Ser Asn Ile Met Met Gln Arg Gly Asn Phe Arg 
385                 390                 395                 400 


Gly Pro Arg Arg Ile Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
                405                 410                 415     


Ile Ala Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
            420                 425                 430         


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
        435                 440                 445             


Phe Leu Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe 
    450                 455                 460                 


Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Gly 
465                 470                 475                 480 


Phe Gly Glu Glu Ile Thr Pro Ser Pro Lys Gln Glu Pro Lys Asp Arg 
                485                 490                 495     


Glu Leu Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp Pro 
            500                 505                 510         


Leu Ser Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
        515                 520                 


<210>  23
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype A consensus Envelope protein sequence

<400>  23

Ser Arg Val Met Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Ile Ile Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asn Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Val Thr Thr Asn Ile Met Lys Gly Glu Ile 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln 
145                 150                 155                 160 


Lys Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Gln Ile Asn Lys 
                165                 170                 175     


Ser Asn Ser Ser Ser Gln Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala 
            180                 185                 190         


Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Glu 
    210                 215                 220                 


Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu Asn Ile Thr Asn Asn 
            260                 265                 270         


Ala Lys Asn Ile Ile Val Gln Leu Thr Lys Pro Val Lys Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


His Cys Asn Val Ser Arg Thr Glu Trp Asn Glu Thr Leu Gln Lys Val 
                325                 330                 335     


Ala Lys Gln Leu Arg Lys Tyr Phe Asn Asn Lys Thr Ile Ile Phe Thr 
            340                 345                 350         


Asn Ser Ser Gly Gly Arg Leu Arg Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr 
    370                 375                 380                 


Trp Asn Gly Asn Gly Thr Lys Lys Lys Asn Ser Thr Glu Ser Asn Asp 
385                 390                 395                 400 


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
                405                 410                 415     


Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg 
            420                 425                 430         


Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asp 
        435                 440                 445             


Asn Asn Ser Lys Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
    450                 455                 460                 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
465                 470                 475                 480 


Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg 
                485                 490                 495     


Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Ser 
        595                 600                 605             


Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Asp Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn 
                645                 650                 655     


Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala 
        675                 680                 685             


Val Leu Ser Val 
    690         


<210>  24
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Envelope protein sequence

<400>  24

Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp Gly 
1               5                   10                  15      


Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asp Leu Ser Gly Glu Lys Met Glu Lys Gly Glu Ile Lys Asn 
    130                 135                 140                 


Cys Ser Phe Asn Ile Thr Thr Ser Ile Arg Asp Lys Val Gln Lys Glu 
145                 150                 155                 160 


Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Asn 
                165                 170                 175     


Thr Ser Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala 
            180                 185                 190         


Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
        195                 200                 205             


Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr 
    210                 215                 220                 


Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg 
225                 230                 235                 240 


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu 
                245                 250                 255     


Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile 
            260                 265                 270         


Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn 
        275                 280                 285             


Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Gln Ala Phe Tyr 
    290                 295                 300                 


Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile 
305                 310                 315                 320 


Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Lys Lys Leu 
                325                 330                 335     


Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser Ser Gly 
            340                 345                 350         


Gly Arg Pro Arg Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn Val Asn 
    370                 375                 380                 


Gly Thr Trp Asn Asn Asn Thr Glu Gly Asn Asp Thr Ile Thr Leu Pro 
385                 390                 395                 400 


Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala 
                405                 410                 415     


Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile 
            420                 425                 430         


Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Thr Asn Glu 
        435                 440                 445             


Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
465                 470                 475                 480 


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
                485                 490                 495     


Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
            500                 505                 510         


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
        515                 520                 525             


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
    530                 535                 540                 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
545                 550                 555                 560 


Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
                565                 570                 575     


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val 
            580                 585                 590         


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp Glu Ile Trp Asp 
        595                 600                 605             


Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Ser 
    610                 615                 620                 


Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
625                 630                 635                 640 


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
                645                 650                 655     


Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile 
            660                 665                 670         


Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
        675                 680                 685             


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
    690                 695         


<210>  25
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype C consensus Envelope protein sequence

<400>  25

Arg Val Arg Gly Ile Leu Arg Asn Cys Gln Gln Trp Trp Ile Trp Gly 
1               5                   10                  15      


Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Met Gly Asn Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Arg Asn Asn Val Asn Asn Asn Asn Thr Met Lys Glu Glu Ile Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys 
145                 150                 155                 160 


Val Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asn Glu Lys 
                165                 170                 175     


Asn Asn Ser Asn Asp Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile 
            180                 185                 190         


Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr 
        195                 200                 205             


Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe 
    210                 215                 220                 


Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His 
225                 230                 235                 240 


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
                245                 250                 255     


Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala 
            260                 265                 270         


Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Val Cys Thr 
        275                 280                 285             


Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln 
    290                 295                 300                 


Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His 
305                 310                 315                 320 


Cys Asn Ile Ser Glu Glu Lys Trp Asn Lys Thr Leu Gln Arg Val Ser 
                325                 330                 335     


Glu Lys Leu Lys Glu His Phe Pro Asn Lys Thr Ile Lys Phe Ala Pro 
            340                 345                 350         


Ser Ser Gly Gly Arg Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg 
        355                 360                 365             


Gly Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Phe Asn Ser Thr Tyr 
    370                 375                 380                 


Met Pro Asn Ser Thr Asn Asn Thr Asn Thr Thr Ile Thr Leu Pro Cys 
385                 390                 395                 400 


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met 
                405                 410                 415     


Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr 
            420                 425                 430         


Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Asn Asp Thr Asn Asp Thr 
        435                 440                 445             


Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser 
    450                 455                 460                 


Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala 
465                 470                 475                 480 


Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val 
                485                 490                 495     


Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
            500                 505                 510         


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
        515                 520                 525             


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
    530                 535                 540                 


Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
545                 550                 555                 560 


Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
                565                 570                 575     


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro 
            580                 585                 590         


Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp Asp Asn 
        595                 600                 605             


Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Thr 
    610                 615                 620                 


Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu 
625                 630                 635                 640 


Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe 
                645                 650                 655     


Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
            660                 665                 670         


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile 
        675                 680                 685         


<210>  26
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype D consensus Envelope protein sequence

<400>  26

Arg Val Arg Gly Ile Lys Arg Asn Tyr Gln His Leu Trp Lys Trp Gly 
1               5                   10                  15      


Thr Met Leu Leu Gly Met Leu Met Thr Cys Ser Val Ala Glu Asn Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Lys Thr Glu Ala His 
    50                  55                  60                  


Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Ile Glu Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asp Gly Met Arg Asn Asp Thr Asn Asp Thr Asn Val Thr Met 
    130                 135                 140                 


Glu Glu Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Val 
145                 150                 155                 160 


Arg Asp Lys Lys Lys Gln Val His Ala Leu Phe Tyr Lys Leu Asp Val 
                165                 170                 175     


Val Pro Ile Asp Asp Asn Asn Thr Asn Asn Ser Asn Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Thr Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser 
            260                 265                 270         


Glu Asn Leu Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Glu 
        275                 280                 285             


Ser Val Thr Ile Asn Cys Thr Arg Pro Tyr Asn Asn Thr Arg Lys Arg 
    290                 295                 300                 


Ile Pro Ile Gly Leu Gly Gln Ala Phe Tyr Thr Thr Arg Gly Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gly Ala Glu Trp Asn 
                325                 330                 335     


Lys Thr Leu Gln Gln Val Ala Lys Lys Leu Gly Asp Leu Leu Asn Lys 
            340                 345                 350         


Thr Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Arg Pro Arg Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Arg Leu Phe Asn Ser Thr Trp Ser Lys Asn Ser Thr Ser Asn Ser Thr 
385                 390                 395                 400 


Lys Glu Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Gly Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Glu 
            420                 425                 430         


Gly Leu Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Ala Asn Asn Ser His Asn Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
465                 470                 475                 480 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Arg Arg 
                485                 490                 495     


Val Val Glu Arg Glu Lys Arg Ala Ile Gly Leu Gly Ala Met Phe Leu 
            500                 505                 510         


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr 
        515                 520                 525             


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
    530                 535                 540                 


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
545                 550                 555                 560 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 
                565                 570                 575     


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
            580                 585                 590         


Lys His Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp Ser Asn 
        595                 600                 605             


Lys Ser Leu Asp Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu 
    610                 615                 620                 


Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Ile Glu Glu 
625                 630                 635                 640 


Ser Gln Thr Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 
                645                 650                 655     


Lys Trp Ala Ser Leu Trp Asn Trp Phe Ser Ile Thr Gln Trp Leu Trp 
            660                 665                 670         


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
        675                 680                 685             


Ile Val Phe Ala Val Leu Ser Leu 
    690                 695     


<210>  27
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Nef-Rev protein sequence

<400>  27

Ser Lys Arg Ser Val Val Gly Trp Pro Thr Val Arg Glu Arg Met Arg 
1               5                   10                  15      


Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala Val Ser Arg Asp Leu 
            20                  25                  30          


Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr Ala Ala Asn Asn Ala 
        35                  40                  45              


Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly Phe Pro 
    50                  55                  60                  


Val Arg Ala Gln Val Ala Leu Arg Ala Met Thr Tyr Lys Ala Ala Val 
65                  70                  75                  80  


Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu Glu Gly Leu Ile 
                85                  90                  95      


Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu Trp Val Tyr His Thr 
            100                 105                 110         


Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro Gly Ile 
        115                 120                 125             


Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val Pro Val Glu 
    130                 135                 140                 


Pro Glu Lys Val Glu Glu Ala Asn Glu Gly Glu Asn Asn Ser Ala Ala 
145                 150                 155                 160 


His Pro Met Ser Leu His Gly Met Asp Asp Pro Glu Arg Glu Val Leu 
                165                 170                 175     


Val Trp Lys Phe Asp Ser Arg Leu Ala Phe His His Met Ala Arg Glu 
            180                 185                 190         


Leu His Pro Glu Tyr Tyr Lys Asp Cys Arg Gly Arg Lys Arg Arg Ser 
        195                 200                 205             


Ala Gly Arg Ser Gly Asp Ser Asp Glu Glu Leu Leu Lys Thr Val Arg 
    210                 215                 220                 


Leu Ile Lys Phe Leu Tyr Gln Ser Asn Pro Pro Pro Ser Pro Glu Gly 
225                 230                 235                 240 


Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln 
                245                 250                 255     


Arg Gln Ile Arg Ser Ile Ser Glu Trp Ile Leu Ser Thr Tyr Leu Gly 
            260                 265                 270         


Arg Pro Ala Glu Pro Val Pro Leu Gln Leu Pro Pro Leu Glu Arg Leu 
        275                 280                 285             


Thr Leu Asp Cys Asn Glu Asp Cys Gly Thr Ser Gly Thr Gln Gly Val 
    290                 295                 300                 


Gly Ser Pro Gln Ile Leu Val Glu Ser Pro Ala Val Leu Glu Ser Gly 
305                 310                 315                 320 


Thr Lys Glu 
            


<210>  28
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gag consensus protein sequence of subtype A, B, C and D

<400>  28

Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala Trp Glu 
1               5                   10                  15      


Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys His 
            20                  25                  30          


Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro Gly 
        35                  40                  45              


Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Gly Gln Leu Gln 
    50                  55                  60                  


Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr 
65                  70                  75                  80  


Val Ala Thr Leu Tyr Cys Val His Glu Lys Ile Glu Val Lys Asp Thr 
                85                  90                  95      


Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys Gln 
            100                 105                 110         


Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val Ser 
        115                 120                 125             


Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln 
    130                 135                 140                 


Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu 
145                 150                 155                 160 


Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu 
                165                 170                 175     


Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly 
            180                 185                 190         


His Gln Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala 
        195                 200                 205             


Ala Glu Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile Ala Pro 
    210                 215                 220                 


Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser 
225                 230                 235                 240 


Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Ser Asn Pro Pro Ile Pro 
                245                 250                 255     


Val Gly Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile 
            260                 265                 270         


Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly Pro 
        275                 280                 285             


Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg 
    290                 295                 300                 


Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr Leu 
305                 310                 315                 320 


Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu 
                325                 330                 335     


Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val 
            340                 345                 350         


Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln 
        355                 360                 365             


Ala Thr Asn Ser Asn Ile Met Met Gln Arg Gly Asn Phe Arg Gly Pro 
    370                 375                 380                 


Arg Arg Ile Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala 
385                 390                 395                 400 


Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys 
                405                 410                 415     


Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu 
            420                 425                 430         


Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln 
        435                 440                 445             


Ser Arg Pro Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Gly Phe Gly 
    450                 455                 460                 


Glu Glu Ile Thr Pro Ser Pro Lys Gln Glu Pro Lys Asp Arg Glu Leu 
465                 470                 475                 480 


Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp Pro Leu Ser 
                485                 490                 495     


Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            500                 505     


<210>  29
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H5N1 HA consensus sequence

<400>  29
atggaaaaga tcgtgctgct gttcgccatc gtgagcctgg tgaagagcga ccagatctgc       60

atcggctacc acgccaacaa cagcaccgag caggtggaca ccatcatgga aaaaaacgtg      120

accgtgaccc acgcccagga catcctggaa aagacccaca acggcaagct gtgcgacctg      180

gacggcgtga agcccctgat cctgcgggac tgcagcgtgg ccggctggct gctgggcaac      240

cccatgtgcg acgagttcat caacgtgccc gagtggagct acatcgtgga gaaggccaac      300

cccgtgaacg acctgtgcta ccccggcgac ttcaacgact acgaggaact gaagcacctg      360

ctgtcccgga tcaaccactt cgagaagatc cagatcatcc ccaagagcag ctggtccagc      420

cacgaggcca gcctgggcgt gagcagcgcc tgcccatacc agggcaagtc cagcttcttc      480

cggaacgtgg tgtggctgat caagaagaac agcacctacc ccaccatcaa gcggagctac      540

aacaacacca accaggaaga tctgctggtc ctgtggggca tccaccaccc caacgacgcc      600

gccgagcaga ccaagctgta ccagaacccc accacctaca tcagcgtggg caccagcacc      660

ctgaaccagc ggctggtgcc ccggatcgcc acccggtcca aggtgaacgg ccagagcggc      720

cggatggaat tcttctggac catcctgaag cccaacgatg ccatcaactt cgagagcaac      780

ggcaacttca tcgcccccga gtacgcctac aagatcgtga agaagggcga cagcaccatc      840

atgaagagcg agctggaata cggcaactgc aacaccaagt gccagacccc catgggcgcc      900

atcaacagca gcatgccctt ccacaacatc caccccctga ccatcggcga gtgccccaag      960

tacgtgaaga gcaacaggct ggtgctggcc accggcctgc ggaacagccc ccagcgggag     1020

cggcgggccg ccgcccgggg cctgttcggc gccatcgccg gcttcatcga gggcggctgg     1080

cagggcatgg tggacgggtg gtacggctac caccacagca atgagcaggg cagcggctac     1140

gccgccgaca aagagagcac ccagaaggcc atcgacggcg tcaccaacaa ggtgaacagc     1200

atcatcgaca agatgaacac ccagttcgag gccgtgggcc gggagttcaa caacctggaa     1260

cggcggatcg agaacctgaa caagaaaatg gaagatggct tcctggacgt gtggacctac     1320

aacgccgagc tgctggtgct gatggaaaac gagcggaccc tggacttcca cgacagcaac     1380

gtgaagaacc tgtacgacaa agtgcggctg cagctgcggg acaacgccaa agagctgggc     1440

aacggctgct tcgagttcta ccacaagtgc gacaacgagt gcatggaaag cgtgcggaac     1500

ggcacctacg actaccccca gtacagcgag gaagcccggc tgaagcggga ggaaatcagc     1560

ggcgtgaaac tggaaagcat cggcatctac cagatcctga gcatctacag caccgtggcc     1620

agcagcctgg ccctggccat catggtggcc ggcctgagcc tgtggatgtg cagcaacggc     1680

agcctgcagt gccggatctg catctag                                         1707


<210>  30
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5N1 HA consensus sequence

<400>  30

Glu Lys Ile Val Leu Leu Phe Ala Ile Val Ser Leu Val Lys Ser Asp 
1               5                   10                  15      


Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val Asp 
            20                  25                  30          


Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile Leu 
        35                  40                  45              


Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro 
    50                  55                  60                  


Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro 
65                  70                  75                  80  


Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val Glu 
                85                  90                  95      


Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn Asp 
            100                 105                 110         


Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu Lys 
        115                 120                 125             


Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser Leu 
    130                 135                 140                 


Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe Arg 
145                 150                 155                 160 


Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile Lys 
                165                 170                 175     


Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly 
            180                 185                 190         


Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln Asn 
        195                 200                 205             


Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu 
    210                 215                 220                 


Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg 
225                 230                 235                 240 


Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe 
                245                 250                 255     


Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile Val 
            260                 265                 270         


Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn 
        275                 280                 285             


Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met 
    290                 295                 300                 


Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr 
305                 310                 315                 320 


Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser Pro 
                325                 330                 335     


Gln Arg Glu Arg Arg Ala Ala Ala Arg Gly Leu Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu 
    370                 375                 380                 


Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile 
385                 390                 395                 400 


Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn 
                405                 410                 415     


Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly 
            420                 425                 430         


Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu 
        435                 440                 445             


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
    450                 455                 460                 


Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser 
                485                 490                 495     


Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg 
            500                 505                 510         


Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Ile 
        515                 520                 525             


Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu 
    530                 535                 540                 


Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser 
545                 550                 555                 560 


Leu Gln Cys Arg Ile Cys Ile 
                565         


<210>  31
<211>  1466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H1N1&H5N1 NA consensus Sequence

<400>  31
ggtaccgaat tcgccaccat ggactggacc tggatcctgt tcctggtggc cgctgccacc       60

cgggtgcaca gcatgaaccc caaccagaag atcatcacca tcggcagcat ctgcatggtg      120

atcggcatcg tgagcctgat gctgcagatc ggcaacatga tcagcatctg ggtgtcccac      180

agcatccaga ccggcaacca gcaccaggcc gagcccatca gcaacaccaa ctttctgacc      240

gagaaggccg tggccagcgt gaccctggcc ggcaacagca gcctgtgccc catcagcggc      300

tgggccgtgt acagcaagga caacagcatc cggatcggca gcaagggcga cgtgttcgtg      360

atccgggagc ccttcatcag ctgcagccac ctggaatgcc ggaccttctt cctgacccag      420

ggggccctgc tgaacgacaa gcacagcaac ggcaccgtga aggacagaag cccctaccgg      480

accctgatga gctgccccgt gggcgaggcc cccagcccct acaacagccg gttcgagagc      540

gtggcctggt ccgccagcgc ctgccacgac ggcaccagct ggctgaccat cggcatcagc      600

ggccctgaca acggcgccgt ggccgtgctg aagtacaacg gcatcatcac cgacaccatc      660

aagagctggc ggaacaacat cctgcggacc caggaaagcg agtgcgcctg cgtgaacggc      720

agctgcttca ccgtgatgac cgacggcccc agcaacggcc aggccagcta caagatcttc      780

aagatggaaa agggcaaggt ggtgaagagc gtggagctgg acgcccccaa ctaccactac      840

gaggaatgca gctgctaccc cgacgccggc gagatcacct gcgtgtgccg ggacaactgg      900

cacggcagca accggccctg ggtgtccttc aaccagaacc tggaatacca gatcggctac      960

atctgcagcg gcgtgttcgg cgacaacccc aggcccaacg atggcaccgg cagctgcggc     1020

cctgtgagcg ccaacggcgc ctacggcgtg aagggcttca gcttcaagta cggcaacggc     1080

gtgtggatcg gccggaccaa gagcaccaac agcagatccg gcttcgagat gatctgggac     1140

cccaacggct ggaccgagac cgacagcagc ttcagcgtga agcaggacat cgtggccatc     1200

accgactggt ccggctacag cggcagcttc gtgcagcacc ccgagctgac cggcctggac     1260

tgcatccggc cctgcttttg ggtggagctg atcagaggca ggcccaaaga gagcaccatc     1320

tggaccagcg gcagcagcat cagcttttgc ggcgtgaaca gcgacaccgt gagctggtcc     1380

tggcccgacg gcgccgagct gcccttcacc atcgacaagt acccctacga cgtgcccgac     1440

tacgcctgat gagcggccgc gagctc                                          1466


<210>  32
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H1N1&H5N1 NA consensus protein Sequence

<400>  32

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys 
            20                  25                  30          


Met Val Ile Gly Ile Val Ser Leu Met Leu Gln Ile Gly Asn Met Ile 
        35                  40                  45              


Ser Ile Trp Val Ser His Ser Ile Gln Thr Gly Asn Gln His Gln Ala 
    50                  55                  60                  


Glu Pro Ile Ser Asn Thr Asn Phe Leu Thr Glu Lys Ala Val Ala Ser 
65                  70                  75                  80  


Val Thr Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Ser Gly Trp Ala 
                85                  90                  95      


Val Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val 
            100                 105                 110         


Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg 
        115                 120                 125             


Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn 
    130                 135                 140                 


Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro 
145                 150                 155                 160 


Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala 
                165                 170                 175     


Trp Ser Ala Ser Ala Cys His Asp Gly Thr Ser Trp Leu Thr Ile Gly 
            180                 185                 190         


Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly 
        195                 200                 205             


Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Val Met 
225                 230                 235                 240 


Thr Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe Lys Met 
                245                 250                 255     


Glu Lys Gly Lys Val Val Lys Ser Val Glu Leu Asp Ala Pro Asn Tyr 
            260                 265                 270         


His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ala Gly Glu Ile Thr Cys 
        275                 280                 285             


Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe 
    290                 295                 300                 


Asn Gln Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe 
305                 310                 315                 320 


Gly Asp Asn Pro Arg Pro Asn Asp Gly Thr Gly Ser Cys Gly Pro Val 
                325                 330                 335     


Ser Ala Asn Gly Ala Tyr Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly 
            340                 345                 350         


Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Thr Asn Ser Arg Ser Gly 
        355                 360                 365             


Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Ser 
    370                 375                 380                 


Phe Ser Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser Gly Tyr 
385                 390                 395                 400 


Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile 
                405                 410                 415     


Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Ser 
            420                 425                 430         


Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser 
        435                 440                 445             


Asp Thr Val Ser Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr 
    450                 455                 460                 


Ile Asp Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
465                 470                 475     


<210>  33
<211>  875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H1N1&H5N1 M1 consensus sequence

<400>  33
ggtaccggat ccgccaccat ggactggacc tggattctgt tcctggtggc cgctgccacc       60

cgggtgcaca gcatgagcct gctgaccgag gtggagacct acgtgctgtc catcatcccc      120

agcggccctc tgaaggccga gatcgcccag cggctggaag atgtgttcgc cggcaagaac      180

accgacctgg aagccctgat ggaatggctg aaaacccggc ccatcctgag ccccctgacc      240

aagggcatcc tgggcttcgt gttcaccctg accgtgccca gcgagcgggg cctgcagcgg      300

cggagattcg tgcagaacgc cctgaacggc aacggcgacc ccaacaacat ggaccgggcc      360

gtgaagctgt acaagaagct gaagcgggag atcaccttcc acggcgccaa agaggtggcc      420

ctgagctaca gcacaggcgc cctggccagc tgcatgggcc tgatctacaa ccggatgggc      480

accgtgacca ccgaggtggc cttcggcctg gtgtgcgcca cctgcgagca gatcgccgac      540

agccagcaca gatcccaccg gcagatggcc accaccacca accccctgat ccggcacgag      600

aaccggatgg tcctggcctc caccaccgcc aaggccatgg aacagatggc cggcagcagc      660

gagcaggccg ccgaagccat ggaagtggcc agccaggcca ggcagatggt gcaggccatg      720

cggaccatcg gcacccaccc cagcagcagc gccggactgc gggacgacct gctggaaaac      780

ctgcaggcct accagaaacg gatgggcgtg cagatgcagc ggttcaagta cccctacgac      840

gtgcccgact acgcctgatg agcggccgcg agctc                                 875


<210>  34
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H1N1&H5N1 M1 consensus protein sequence

<400>  34

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile 
            20                  25                  30          


Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp 
        35                  40                  45              


Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Ala Leu Met Glu Trp Leu 
    50                  55                  60                  


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
65                  70                  75                  80  


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
                85                  90                  95      


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
            100                 105                 110         


Arg Ala Val Lys Leu Tyr Lys Lys Leu Lys Arg Glu Ile Thr Phe His 
        115                 120                 125             


Gly Ala Lys Glu Val Ala Leu Ser Tyr Ser Thr Gly Ala Leu Ala Ser 
    130                 135                 140                 


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Thr Val Thr Thr Glu Val 
145                 150                 155                 160 


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
                165                 170                 175     


His Arg Ser His Arg Gln Met Ala Thr Thr Thr Asn Pro Leu Ile Arg 
            180                 185                 190         


His Glu Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu 
        195                 200                 205             


Gln Met Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala 
    210                 215                 220                 


Ser Gln Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His 
225                 230                 235                 240 


Pro Ser Ser Ser Ala Gly Leu Arg Asp Asp Leu Leu Glu Asn Leu Gln 
                245                 250                 255     


Ala Tyr Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys Tyr Pro 
            260                 265                 270         


Tyr Asp Val Pro Asp Tyr Ala 
        275                 


<210>  35
<211>  1700
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H5N1 M2E-NP consensus sequence

<400>  35
ggtaccgaat tcgccaccat ggactggacc tggatcctgt tcctggtcgc tgccgccacc       60

agggtgcaca gcagcctgct gaccgaggtg gagaccccca cccggaacga gtggggctgc      120

cggtgcagcg acagcagcga ccggggcagg aagcggagaa gcgccagcca gggcaccaag      180

cggagctacg agcagatgga aacaggcggc gagcggcaga acgccaccga gatccgggcc      240

agcgtgggca gaatggtcgg cggcatcggc cggttctaca tccagatgtg caccgagctg      300

aagctgtccg actacgaggg ccggctgatc cagaacagca tcaccatcga gcggatggtg      360

ctgtccgcct tcgacgagcg gcggaacaga tacctggaag agcaccccag cgccggcaag      420

gaccccaaga aaaccggcgg acccatctac cggcggaggg acggcaagtg ggtgcgggag      480

ctgatcctgt acgacaaaga ggaaatccgg cggatctggc ggcaggccaa caacggcgag      540

gacgccacag ccggcctgac ccacctgatg atctggcaca gcaacctgaa cgacgccacc      600

taccagcgga caagggctct ggtccggacc ggcatggacc cccggatgtg cagcctgatg      660

cagggcagca cactgcccag aagaagcgga gccgctggcg cagccgtgaa gggcgtgggc      720

accatggtga tggaactgat ccggatgatc aagcggggca tcaacgaccg gaatttttgg      780

aggggcgaga acggcaggcg gacccggatc gcctacgagc ggatgtgcaa catcctgaag      840

ggcaagttcc agacagccgc ccagcgggcc atgatggacc aggtccggga gagccggaac      900

cccggcaacg ccgagatcga ggacctgatc ttcctggcca gaagcgccct gatcctgcgg      960

ggcagcgtgg cccacaagag ctgcctgccc gcctgcgtgt acggactggc cgtggccagc     1020

ggctacgact tcgagcggga gggctacagc ctggtcggca tcgacccctt ccggctgctg     1080

cagaactccc aggtgttcag cctgatccgg cccaacgaga accccgccca caagtcccag     1140

ctggtctgga tggcctgcca cagcgccgcc ttcgaggatc tgagagtgag cagcttcatc     1200

cggggcacca gagtggtgcc caggggccag ctgtccacca ggggcgtgca gatcgccagc     1260

aacgagaaca tggaagccat ggacagcaac accctggaac tgcggagccg gtactgggcc     1320

atccggacca gaagcggcgg caacaccaac cagcagcggg ccagcgccgg acagatcagc     1380

gtgcagccca ccttctccgt gcagcggaac ctgcccttcg agagggccac catcatggcc     1440

gccttcaccg gcaacaccga gggccggacc agcgacatgc ggaccgagat catcaggatg     1500

atggaaagcg ccaggcccga ggacgtgagc ttccagggca ggggcgtgtt cgagctgtcc     1560

gatgagaagg ccaccaaccc catcgtgccc agcttcgaca tgaacaacga gggcagctac     1620

ttcttcggcg acaacgccga ggaatacgac aactacccct acgacgtgcc cgactacgcc     1680

tgatgagcgg ccgcgagctc                                                 1700


<210>  36
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5N1 M2E-NP consensus protein sequence

<400>  36

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Glu Trp 
            20                  25                  30          


Gly Cys Arg Cys Ser Asp Ser Ser Asp Arg Gly Arg Lys Arg Arg Ser 
        35                  40                  45              


Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Gly Gly 
    50                  55                  60                  


Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met Val 
65                  70                  75                  80  


Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys Leu 
                85                  90                  95      


Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu Arg 
            100                 105                 110         


Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu Glu 
        115                 120                 125             


His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile Tyr 
    130                 135                 140                 


Arg Arg Arg Asp Gly Lys Trp Val Arg Glu Leu Ile Leu Tyr Asp Lys 
145                 150                 155                 160 


Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp Ala 
                165                 170                 175     


Thr Ala Gly Leu Thr His Leu Met Ile Trp His Ser Asn Leu Asn Asp 
            180                 185                 190         


Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp Pro 
        195                 200                 205             


Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser Gly 
    210                 215                 220                 


Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu Leu 
225                 230                 235                 240 


Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg Gly 
                245                 250                 255     


Glu Asn Gly Arg Arg Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn Ile 
            260                 265                 270         


Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp Gln 
        275                 280                 285             


Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu Ile 
    290                 295                 300                 


Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His Lys 
305                 310                 315                 320 


Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Ala Ser Gly Tyr 
                325                 330                 335     


Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe Arg 
            340                 345                 350         


Leu Leu Gln Asn Ser Gln Val Phe Ser Leu Ile Arg Pro Asn Glu Asn 
        355                 360                 365             


Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala Ala 
    370                 375                 380                 


Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Arg Val Val 
385                 390                 395                 400 


Pro Arg Gly Gln Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn Glu 
                405                 410                 415     


Asn Met Glu Ala Met Asp Ser Asn Thr Leu Glu Leu Arg Ser Arg Tyr 
            420                 425                 430         


Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg Ala 
        435                 440                 445             


Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg Asn 
    450                 455                 460                 


Leu Pro Phe Glu Arg Ala Thr Ile Met Ala Ala Phe Thr Gly Asn Thr 
465                 470                 475                 480 


Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met Glu 
                485                 490                 495     


Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe Glu 
            500                 505                 510         


Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp Met 
        515                 520                 525             


Asn Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr Asp 
    530                 535                 540                 


Asn Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
545                 550                 


<210>  37
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE leader sequence

<400>  37

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  38
<211>  818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV genotype 16 E6-E7 DNA sequence

<400>  38
gaattcgcca ccatggactg gacctggatc ctgttcctgg tggccgccgc cacacgggtg       60

cacagcttcc aggaccccca ggagagcggc agaaagctgc ctcagctgtg taccgagctg      120

cagaccacca tccacgacat catcctggag tgtgtgtact gtaagcagca gctgctgagg      180

agagaggtgt acgaccggga cctgtgtatc gtgtacaggg acggcaatcc ctacgccgtg      240

tgtgacaagt gcctgaagtt ctacagcaag atcagcgagt accggcacta ctgctacagc      300

ctgtacggca ccaccctgga gcagcagtac aacaagcccc tgtgtgacct gctgatccgg      360

tgtatcaact gccagaagcc cctgcagaga cacctggaca agaagcagcg gttccacaac      420

atcaggggca gatggaccgg cagatgtatg agctgctgcc ggagcagcag aaccagaagg      480

gagacccagc tgagaggccg gaagagaaga agccacggcg atacccccac cctgcacgag      540

tacatgctgg acctgcagcc tgagaccacc gatctgtacg gctacggcca gctgaatgac      600

agcagcgagg aggaggatga gatcgacggc cctgccggcc aggccgagcc cgacagagcc      660

cactacaaca tcgtgacctt ttgctgtaag tgtgacagca ccctgagact gtgcgtgcag      720

agcacccacg tggacatcag aaccctggag gatctgctga tgggcaccct gggcatcgtg      780

tgtcccatct gctcccagaa accctgatga gcggccgc                              818


<210>  39
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV genotype 16 E6-E7 protein sequence

<400>  39

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Gln Asp Pro Gln Glu Ser Gly Arg Lys Leu Pro Gln Leu 
            20                  25                  30          


Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val 
        35                  40                  45              


Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Arg Asp Leu 
    50                  55                  60                  


Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys 
65                  70                  75                  80  


Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser 
                85                  90                  95      


Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp 
            100                 105                 110         


Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Gln Arg His Leu 
        115                 120                 125             


Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg 
    130                 135                 140                 


Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155                 160 


Arg Gly Arg Lys Arg Arg Ser His Gly Asp Thr Pro Thr Leu His Glu 
                165                 170                 175     


Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly 
            180                 185                 190         


Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala 
        195                 200                 205             


Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
    210                 215                 220                 


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
225                 230                 235                 240 


Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
                245                 250                 255     


Cys Pro Ile Cys Ser Gln Lys Pro 
            260                 


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E6 immunodominant epitope

<400>  40

Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E7 immunodominant epitope

<400>  41

Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys 
1               5                   10                  15  


<210>  42
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E6 consensus sequence

<400>  42

Phe Gln Asp Pro Gln Glu Ser Gly Arg Lys Leu Pro Gln Leu Cys Thr 
1               5                   10                  15      


Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr Cys 
            20                  25                  30          


Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Arg Asp Leu Cys Ile 
        35                  40                  45              


Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys 
    50                  55                  60                  


Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr 
65                  70                  75                  80  


Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu 
                85                  90                  95      


Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Gln Arg His Leu Asp Lys 
            100                 105                 110         


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
        115                 120                 125             


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
    130                 135                 140         


<210>  43
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E7 consensus sequence

<400>  43

His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro 
1               5                   10                  15      


Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser Glu 
            20                  25                  30          


Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg 
        35                  40                  45              


Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu 
    50                  55                  60                  


Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp 
65                  70                  75                  80  


Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys 
                85                  90                  95      


Pro 
    


<210>  44
<211>  1766
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCV genotype 1a and 1b consensus E1-E2 DNA sequence

<400>  44
gaattcgcca ccatggactg gacctggatc ctgttcctgg tggccgctgc aacacgggtg       60

cacagctacc aagtgaggaa tagcagcggc ctgtaccacg tgaccaacga ctgctccaac      120

agcagcatcg tgtacgaggc cgccgacatg atcatgcaca cccccggctg tgtgccctgt      180

gtgagagagg gcaacagctc cagatgctgg gtggccctga cccctaccgt ggccgccaga      240

gatggcagcc tgcccaccac caccctgagg agacacgtgg acctgcttgt gggcagcgcc      300

accctgtgta gcgccatgta tgtgggcgat ctgtgtggca gcgtgtttct tgtgggccag      360

ctgttcacct tcagccccag aaggcactgg accgtgcagg actgtaactg ctccatctac      420

cccggccaca tcaccggcca cagaatggcc tgggacatga tgatgaactg gagccctacc      480

accgccctgg tggtgtccca gctgctgaga atccctcagg ccatcgtgga catggtggcc      540

ggagcccact ggggcgtgct ggccggcatc gcctacttca gcatggtggg caactgggcc      600

aaggtgctcg tggtgctgct gctgttcgcc ggcgtggacg gcagaggcag gaagagaagg      660

agcgagaccc acgtgaccgg cggcaccgcc ggcagaacca cagccggcct tgtgggcctg      720

ttcacccctg gcgccaagca gaacatccag ctgatcaaca ccaacggcag ctggcacatc      780

aacagcaccg ccctgaactg taacgacagc ctgaacaccg gctggctggc cggcctgttc      840

taccagcaca agttcaacag cagcggctgc cccgagagaa tggccagctg tagacccctg      900

gatgagttcg cccagggctg gggccccatc acctacgcca atggcagcgg ccctgaccag      960

agaccctact gctggcacta cgcccccaga ccctgtggca tcgtgcccgc caagagcgtg     1020

tgtggccccg tgtactgctt cacccctagc cccgtggttg tgggcaccac cgacagaagc     1080

ggagccccca cctacagctg gggcgagaac gagaccgacg tgctggtgct gaacaacacc     1140

agaccccccc tgggcaattg gttcggctgt acctggatga acagcaccgg cttcaccaaa     1200

gtgtgtggcg cccctccctg tgtgatcggc ggagtgggca acaacaccct gacctgcccc     1260

accgactgct tcagaaagca ccccgaggcc acctactcca gatgtggcag cggaccttgg     1320

ctgaccccca gatgtatggt ggactacccc tacaggctgt ggcactaccc ctgtaccgtg     1380

aacttcacca tcttcaaagt gaggatgtat gtggggggcg tggagcacag actggaggcc     1440

gcctgtaatt ggaccagggg cgagagatgt gacctggagg accgggatag aagcgagctg     1500

tcccctctgc tgctgtccac caccgagtgg caggtgctgc cttgtagctt caccaccctg     1560

cccgccctga gcaccggcct gatccacctg caccagaaca tcgtggacgt gcagtacctg     1620

tacggagtgg gctctagcat cgtgtcctgg gccatcaagt gggagtacgt ggtgctgctg     1680

ttcctgctgc tggccgacgc cagagtgtgt agctgcctgt ggatgatgct gctgatcagc     1740

caggccgagg cctgatgagc ggccgc                                          1766


<210>  45
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV genotype 1a and 1b consensus E1-E2 protein sequence

<400>  45

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Tyr Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn 
            20                  25                  30          


Asp Cys Ser Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met 
        35                  40                  45              


His Thr Pro Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg 
    50                  55                  60                  


Cys Trp Val Ala Leu Thr Pro Thr Val Ala Ala Arg Asp Gly Ser Leu 
65                  70                  75                  80  


Pro Thr Thr Thr Leu Arg Arg His Val Asp Leu Leu Val Gly Ser Ala 
                85                  90                  95      


Thr Leu Cys Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe 
            100                 105                 110         


Leu Val Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Val 
        115                 120                 125             


Gln Asp Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg 
    130                 135                 140                 


Met Ala Trp Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val 
145                 150                 155                 160 


Val Ser Gln Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala 
                165                 170                 175     


Gly Ala His Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val 
            180                 185                 190         


Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val 
        195                 200                 205             


Asp Gly Arg Gly Arg Lys Arg Arg Ser Glu Thr His Val Thr Gly Gly 
    210                 215                 220                 


Thr Ala Gly Arg Thr Thr Ala Gly Leu Val Gly Leu Phe Thr Pro Gly 
225                 230                 235                 240 


Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile 
                245                 250                 255     


Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser Leu Asn Thr Gly Trp Leu 
            260                 265                 270         


Ala Gly Leu Phe Tyr Gln His Lys Phe Asn Ser Ser Gly Cys Pro Glu 
        275                 280                 285             


Arg Met Ala Ser Cys Arg Pro Leu Asp Glu Phe Ala Gln Gly Trp Gly 
    290                 295                 300                 


Pro Ile Thr Tyr Ala Asn Gly Ser Gly Pro Asp Gln Arg Pro Tyr Cys 
305                 310                 315                 320 


Trp His Tyr Ala Pro Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val 
                325                 330                 335     


Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr 
            340                 345                 350         


Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser Trp Gly Glu Asn Glu Thr 
        355                 360                 365             


Asp Val Leu Val Leu Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe 
    370                 375                 380                 


Gly Cys Thr Trp Met Asn Ser Thr Gly Phe Thr Lys Val Cys Gly Ala 
385                 390                 395                 400 


Pro Pro Cys Val Ile Gly Gly Val Gly Asn Asn Thr Leu Thr Cys Pro 
                405                 410                 415     


Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly 
            420                 425                 430         


Ser Gly Pro Trp Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg 
        435                 440                 445             


Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Ile Phe Lys Val Arg 
    450                 455                 460                 


Met Tyr Val Gly Gly Val Glu His Arg Leu Glu Ala Ala Cys Asn Trp 
465                 470                 475                 480 


Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Leu 
                485                 490                 495     


Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp Gln Val Leu Pro Cys Ser 
            500                 505                 510         


Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln 
        515                 520                 525             


Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Ser Ile Val 
    530                 535                 540                 


Ser Trp Ala Ile Lys Trp Glu Tyr Val Val Leu Leu Phe Leu Leu Leu 
545                 550                 555                 560 


Ala Asp Ala Arg Val Cys Ser Cys Leu Trp Met Met Leu Leu Ile Ser 
                565                 570                 575     


Gln Ala Glu Ala 
            580 


<210>  46
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV E1 consensus sequence

<400>  46

Tyr Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys 
1               5                   10                  15      


Ser Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr 
            20                  25                  30          


Pro Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp 
        35                  40                  45              


Val Ala Leu Thr Pro Thr Val Ala Ala Arg Asp Gly Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Leu Arg Arg His Val Asp Leu Leu Val Gly Ser Ala Thr Leu 
65                  70                  75                  80  


Cys Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val 
                85                  90                  95      


Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Val Gln Asp 
            100                 105                 110         


Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala 
        115                 120                 125             


Trp Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser 
    130                 135                 140                 


Gln Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala 
145                 150                 155                 160 


His Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn 
                165                 170                 175     


Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Gly 
            180                 185                 190         


<210>  47
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV E2 consensus sequence

<400>  47

Glu Thr His Val Thr Gly Gly Thr Ala Gly Arg Thr Thr Ala Gly Leu 
1               5                   10                  15      


Val Gly Leu Phe Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Asp 
65                  70                  75                  80  


Glu Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Asn Gly Ser Gly 
                85                  90                  95      


Pro Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly 
            100                 105                 110         


Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        115                 120                 125             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr 
    130                 135                 140                 


Ser Trp Gly Glu Asn Glu Thr Asp Val Leu Val Leu Asn Asn Thr Arg 
145                 150                 155                 160 


Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
                165                 170                 175     


Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly 
            180                 185                 190         


Asn Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
        195                 200                 205             


Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
    210                 215                 220                 


Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn 
225                 230                 235                 240 


Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
                245                 250                 255     


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
            260                 265                 270         


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu 
        275                 280                 285             


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
    290                 295                 300                 


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val 
                325                 330                 335     


Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu 
            340                 345                 350         


Trp Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
        355                 360             


<210>  48
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proinsulin antigen

<400>  48

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  49
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insulin antigen 1

<400>  49

Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Ser His Leu Val Glu 
1               5                   10                  15      


Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly 
            20                  25      


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insulin antigen 2

<400>  50

Leu Tyr Leu Val Cys Gly Glu Arg Gly 
1               5                   


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insulin antigen 3

<400>  51

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
1               5                   10                  15  


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6P antigen IGRP13-25

<400>  52

Gln His Leu Gln Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6P antigen IGRP23-35

<400>  53

Tyr Thr Phe Leu Asn Phe Met Ser Asn Val Gly Asp Pro 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6P antigen IGRP226-238

<400>  54

Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6P antigen IGRP247-259

<400>  55

Asp Trp Ile His Ile Asp Thr Thr Pro Phe Ala Gly Leu 
1               5                   10              


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6Pase-alpha228-240

<400>  56

Lys Gly Leu Gly Val Asp Leu Leu Trp Thr Leu Glu Lys 
1               5                   10              


<210>  57
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6Pase-alpha249-261

<400>  57

Glu Trp Val His Ile Asp Thr Thr Pro Phe Ala Ser Leu 
1               5                   10              


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGRP218-230

<400>  58

Phe Thr Leu Gly Leu Asp Leu Ser Trp Ser Ile Ser Leu 
1               5                   10              


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGRP239-251

<400>  59

Glu Trp Ile His Val Asp Ser Arg Pro Phe Ala Ser Leu 
1               5                   10              


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG antigen 1

<400>  60

His Pro Ile Arg Ala Leu Val Gly Asp Glu Val Glu Leu Pro 
1               5                   10                  


<210>  61
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG antigen 2

<400>  61

Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg 
1               5                   10                  15      


Asn Gly Lys Asp 
            20  


<210>  62
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG antigen 3

<400>  62

Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val 
1               5                   10                  15      


Leu Leu Ala Val Leu Pro Val Leu Leu Leu 
            20                  25      


<210>  63
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZP3 PEPTIDE 330-342

<400>  63

Asn Ser Ser Ser Ser Gln Phe Gln Ile His Gly Pro Arg 
1               5                   10              


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZP3 PEPTIDE 335-342

<400>  64

Gln Phe Gln Ile His Gly Pro Arg 
1               5               


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZP3 PEPTIDE 330-340

<400>  65

Asn Ser Ser Ser Ser Gln Phe Gln Ile His Gly 
1               5                   10      


<210>  66
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myocarditis  antigen with amino acids 614-643

<400>  66

Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Thr Tyr Ala Ser Ala Asp 
1               5                   10                  15      


Thr Gly Asp Ser Gly Lys Gly Lys Gly Gly Lys Lys Lys Gly 
            20                  25                  30  


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myocarditis antigen with amino acids 735-747

<400>  67

Gly Gln Phe Ile Asp Ser Gly Lys Ala Gly Ala Glu Lys Leu 
1               5                   10                  


<210>  68
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myocarditis antigen with amino acids 947-960

<400>  68

Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu Glu 
1               5                   10                  


<210>  69
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP4  1-20

<400>  69

Met Gly Ala Gln Val Ser Thr Gln Lys Thr Gly Ala His Glu Thr Ser 
1               5                   10                  15      


Leu Ser Ala Ser 
            20  


<210>  70
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP4 21-40

<400>  70

Gly Asn Ser Ile Ile His Tyr Thr Asn Ile Asn Tyr Tyr Lys Asp Ala 
1               5                   10                  15      


Ala Ser Asn Ser 
            20  


<210>  71
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP4  31-50

<400>  71

Asn Tyr Tyr Lys Asp Ala Ala Ser Asn Ser Ala Asn Arg Gln Asp Phe 
1               5                   10                  15      


Thr Gln Asp Pro 
            20  


<210>  72
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP4  41-60

<400>  72

Ala Asn Arg Gln Asp Phe Thr Gln Asp Pro Ser Lys Phe Thr Glu Pro 
1               5                   10                  15      


Val Lys Asp Val 
            20  


<210>  73
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP4 51-70

<400>  73

Ser Lys Phe Thr Glu Pro Val Lys Asp Val Met Ile Lys Ser Leu Pro 
1               5                   10                  15      


Ala Leu Asn Ser 
            20  


<210>  74
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2  61-80

<400>  74

Met Ile Lys Ser Leu Pro Ala Leu Asn Ser Pro Thr Val Glu Glu Cys 
1               5                   10                  15      


Gly Tyr Ser Asp 
            20  


<210>  75
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2  71-90

<400>  75

Pro Thr Val Glu Glu Cys Gly Tyr Ser Asp Arg Val Arg Ser Ile Thr 
1               5                   10                  15      


Leu Gly Asn Ser 
            20  


<210>  76
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2 81-100

<400>  76

Arg Val Arg Ser Ile Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
1               5                   10                  15      


Cys Ala Asn Val 
            20  


<210>  77
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2  91-110

<400>  77

Thr Ile Thr Thr Gln Glu Cys Ala Asn Val Val Val Gly Tyr Gly Val 
1               5                   10                  15      


Trp Pro Asp Tyr 
            20  


<210>  78
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2  111-130

<400>  78

Leu Ser Asp Glu Glu Ala Thr Ala Glu Asp Gln Pro Thr Gln Pro Asp 
1               5                   10                  15      


Val Ala Thr Cys 
            20  


<210>  79
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2  121-140

<400>  79

Gln Pro Thr Gln Pro Asp Val Ala Thr Cys Arg Phe Tyr Thr Leu Asn 
1               5                   10                  15      


Ser Val Lys Trp 
            20  


<210>  80
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2  131-150

<400>  80

Arg Phe Tyr Thr Leu Asn Ser Val Lys Trp Glu Met Gln Ser Ala Gly 
1               5                   10                  15      


Trp Trp Trp Lys 
            20  


<210>  81
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2  151-170

<400>  81

Phe Pro Asp Ala Leu Ser Glu Met Gly Leu Phe Gly Gln Asn Met Gln 
1               5                   10                  15      


Tyr His Tyr Leu 
            20  


<210>  82
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2  161-180

<400>  82

Phe Gly Gln Asn Met Gln Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
1               5                   10                  15      


Ile His Val Gln 
            20  


<210>  83
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2  171-190

<400>  83

Gly Arg Ser Gly Tyr Thr Ile His Val Gln Cys Asn Ala Ser Lys Phe 
1               5                   10                  15      


His Gln Gly Cys 
            20  


<210>  84
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2 181-200

<400>  84

Cys Asn Ala Ser Lys Phe His Gln Gly Cys Leu Leu Val Val Cys Val 
1               5                   10                  15      


Pro Glu Ala Glu 
            20  


<210>  85
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2 211-230

<400>  85

Ala Tyr Gly Asp Leu Cys Gly Gly Glu Thr Ala Lys Ser Phe Glu Gln 
1               5                   10                  15      


Asn Ala Ala Thr 
            20  


<210>  86
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2 221-240

<400>  86

Ala Lys Ser Phe Glu Gln Asn Ala Ala Thr Gly Lys Thr Ala Val Gln 
1               5                   10                  15      


Thr Ala Val Cys 
            20  


<210>  87
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2 231-250

<400>  87

Gly Lys Thr Ala Val Gln Thr Ala Val Cys Asn Ala Gly Met Gly Val 
1               5                   10                  15      


Gly Val Gly Asn 
            20  


<210>  88
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2 251-270

<400>  88

Leu Thr Ile Tyr Pro His Gln Trp Ile Asn Leu Arg Thr Asn Asn Ser 
1               5                   10                  15      


Ala Thr Ile Val 
            20  


<210>  89
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2 261-280

<400>  89

Leu Arg Thr Asn Asn Ser Ala Thr Ile Val Met Pro Tyr Ile Asn Ser 
1               5                   10                  15      


Val Pro Met Asp 
            20  


<210>  90
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2 271-290

<400>  90

Met Pro Tyr Ile Asn Ser Val Pro Met Asp Asn Met Phe Arg His Asn 
1               5                   10                  15      


Asn Phe Thr Leu 
            20  


<210>  91
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2 281-300

<400>  91

Asn Met Phe Arg His Asn Asn Phe Thr Leu Met Ile Ile Pro Phe Ala 
1               5                   10                  15      


Pro Leu Asp Tyr 
            20  


<210>  92
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 321-340

<400>  92

Tyr Asn Gly Leu Arg Leu Ala Gly His Gln Gly Leu Pro Thr Met Leu 
1               5                   10                  15      


Thr Pro Gly Ser 
            20  


<210>  93
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 351-370

<400>  93

Ser Pro Ser Ala Met Pro Gln Phe Asp Val Thr Pro Glu Met Asn Ile 
1               5                   10                  15      


Pro Gly Gln Val 
            20  


<210>  94
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 361-380

<400>  94

Thr Pro Glu Met Asn Ile Pro Gly Gln Val Arg Asn Leu Met Glu Ile 
1               5                   10                  15      


Ala Glu Val Asp 
            20  


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 371-390

<400>  95

Arg Asn Leu Met Glu Ile Ala Glu Val Asp Ser Val Val Pro Ile Asn 
1               5                   10                  15      


Asn Leu Lys Ala 
            20  


<210>  96
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 381-400

<400>  96

Ser Val Val Pro Ile Asn Asn Leu Lys Ala Asn Leu Met Thr Met Glu 
1               5                   10                  15      


Ala Tyr Arg Val 
            20  


<210>  97
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 391-410

<400>  97

Asn Leu Met Thr Met Glu Ala Tyr Arg Val Gln Val Arg Ser Thr Asp 
1               5                   10                  15      


Glu Met Gly Gly 
            20  


<210>  98
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 401-420

<400>  98

Gln Val Arg Ser Thr Asp Glu Met Gly Gly Gln Ile Phe Gly Phe Pro 
1               5                   10                  15      


Leu Gln Pro Gly 
            20  


<210>  99
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 411-430

<400>  99

Gln Ile Phe Gly Phe Pro Leu Gln Pro Gly Ala Ser Ser Val Leu Gln 
1               5                   10                  15      


Arg Thr Leu Leu 
            20  


<210>  100
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 421-440

<400>  100

Ala Ser Ser Val Leu Gln Arg Thr Leu Leu Gly Glu Ile Leu Asn Tyr 
1               5                   10                  15      


Tyr Thr His Trp 
            20  


<210>  101
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 431-450

<400>  101

Gly Glu Ile Leu Asn Tyr Tyr Thr His Trp Ser Gly Ser Leu Lys Leu 
1               5                   10                  15      


Thr Phe Val Phe 
            20  


<210>  102
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 441-460

<400>  102

Ser Gly Ser Leu Lys Leu Thr Phe Val Phe Cys Gly Ser Ala Met Ala 
1               5                   10                  15      


Thr Gly Lys Phe 
            20  


<210>  103
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 511-530

<400>  103

Asp Asp Lys Tyr Thr Ala Ser Gly Phe Ile Ser Cys Trp Tyr Gln Thr 
1               5                   10                  15      


Asn Val Ile Val 
            20  


<210>  104
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3 541-560

<400>  104

Met Cys Phe Val Ser Ala Cys Asn Asp Phe Ser Val Arg Met Leu Arg 
1               5                   10                  15      


Asp Thr Gln Phe 
            20  


<210>  105
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 671-690

<400>  105

Leu Arg Arg Lys Met Glu Met Phe Thr Tyr Ile Arg Cys Asp Met Glu 
1               5                   10                  15      


Leu Thr Phe Val 
            20  


<210>  106
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 721-740

<400>  106

Val Pro Thr Ser Val Asn Asp Tyr Val Trp Gln Thr Ser Thr Asn Pro 
1               5                   10                  15      


Ser Ile Phe Trp 
            20  


<210>  107
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 731-750

<400>  107

Gln Thr Ser Thr Asn Pro Ser Ile Phe Trp Thr Glu Gly Asn Ala Pro 
1               5                   10                  15      


Pro Arg Met Ser 
            20  


<210>  108
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 741-760

<400>  108

Thr Glu Gly Asn Ala Pro Pro Arg Met Ser Ile Pro Phe Met Ser Ile 
1               5                   10                  15      


Gly Asn Ala Tyr 
            20  


<210>  109
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 751-770

<400>  109

Ile Pro Phe Met Ser Ile Gly Asn Ala Tyr Thr Met Phe Tyr Asp Gly 
1               5                   10                  15      


Trp Ser Asn Phe 
            20  


<210>  110
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 771-790

<400>  110

Ser Arg Asp Gly Ile Tyr Gly Tyr Asn Ser Leu Asn Asn Met Gly Thr 
1               5                   10                  15      


Ile Tyr Ala Arg 
            20  


<210>  111
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 781-800

<400>  111

Leu Asn Asn Met Gly Thr Ile Tyr Ala Arg His Val Asn Asp Ser Ser 
1               5                   10                  15      


Pro Gly Gly Leu 
            20  


<210>  112
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 791-810

<400>  112

His Val Asn Asp Ser Ser Pro Gly Gly Leu Thr Ser Thr Ile Arg Ile 
1               5                   10                  15      


Tyr Phe Lys Pro 
            20  


<210>  113
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 831-850

<400>  113

Ser Val Asn Phe Asp Val Glu Ala Val Thr Ala Glu Arg Ala Ser Leu 
1               5                   10                  15      


Ile Thr Thr Gly 
            20  


<210>  114
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  group A streptococcal M5 protein  NT4

<400>  114

Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu 
1               5                   10                  15      


Lys Thr Glu 
            


<210>  115
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  group A streptococcal M5 protein NT5

<400>  115

Lys Lys Glu His Glu Ala Glu Asn Asp Lys Leu Lys Gln Gln Arg Asp 
1               5                   10                  15      


Thr Leu 
        


<210>  116
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  group A streptococcal M5 protein B1B2

<400>  116

Val Lys Asp Lys Ile Ala Lys Glu Gln Glu Asn Lys Glu Thr Ile Gly 
1               5                   10                  15      


Thr Leu 
        


<210>  117
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  group A streptococcal M5 protein B2

<400>  117

Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys 
1               5                   10                  15      


Ile Ala 
        


<210>  118
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  group A streptococcal M5 protein  B3A

<400>  118

Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys Leu 
1               5                   10                  15      


Ala Lys 
        


<210>  119
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  group A streptococcal M5 protein C3

<400>  119

Lys Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln 
1               5                   10                  15      


<210>  120
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 27-44

<400>  120

Leu Lys Thr Lys Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys 
1               5                   10                  15      


Thr Glu 
        


<210>  121
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 59-76 (NT5)

<400>  121

Lys Lys Glu His Glu Ala Glu Asn Asp Lys Leu Lys Gln Gln Arg Asp 
1               5                   10                  15      


Thr Leu 
        


<210>  122
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 72-89 (NT6)

<400>  122

Gln Arg Asp Thr Leu Ser Thr Gln Lys Glu Thr Leu Glu Arg Glu Val 
1               5                   10                  15      


Gln Asn 
        


<210>  123
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 85-102 (NT7)

<400>  123

Arg Glu Val Gln Asn Thr Gln Tyr Asn Asn Glu Thr Leu Lys Ile Lys 
1               5                   10                  15      


Asn Gly 
        


<210>  124
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 98-115 (NT8)

<400>  124

Lys Ile Lys Asn Gly Asp Leu Thr Lys Glu Leu Asn Lys Thr Arg Gln 
1               5                   10                  15      


Glu Leu 
        


<210>  125
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein  111-129 (B1A)

<400>  125

Thr Arg Gln Glu Leu Ala Asn Lys Gln Gln Glu Ser Lys Glu Asn Glu 
1               5                   10                  15      


Lys Ala Leu 
            


<210>  126
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 150-167 (B2)

<400>  126

Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys 
1               5                   10                  15      


Ile Ala 
        


<210>  127
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 176-193 (B3A)

<400>  127

Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys Leu 
1               5                   10                  15      


Ala Lys 
        


<210>  128
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 1-35

<400>  128

Ala Val Thr Arg Gly Thr Ile Asn Asp Pro Gln Arg Ala Lys Glu Ala 
1               5                   10                  15      


Leu Asp Lys Tyr Glu Leu Glu Asn His Asp Leu Lys Thr Lys Asn Glu 
            20                  25                  30          


Gly Leu Lys 
        35  


<210>  129
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 28-54

<400>  129

Lys Thr Lys Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys Thr 
1               5                   10                  15      


Glu Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly 
            20                  25          


<210>  130
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 55-70

<400>  130

Leu Lys Thr Glu Lys Lys Glu His Glu Ala Glu Asn Asp Lys Leu Lys 
1               5                   10                  15      


<210>  131
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 103-132

<400>  131

Asp Leu Thr Lys Glu Leu Asn Lys Thr Arg Gln Glu Leu Ala Asn Lys 
1               5                   10                  15      


Gln Gln Glu Ser Lys Glu Asn Glu Lys Ala Ile Asn Glu Leu 
            20                  25                  30  


<210>  132
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein  133-162

<400>  132

Leu Glu Lys Thr Val Lys Asp Lys Ile Ala Lys Glu Gln Glu Asn Lys 
1               5                   10                  15      


Glu Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val 
            20                  25                  30  


<210>  133
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 209-223

<400>  133

Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys 
1               5                   10                  15      


<210>  134
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 217-237

<400>  134

Ile Ser Asp Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu Asp Ala Ser 
1               5                   10                  15      


Arg Glu Ala Lys Lys 
            20      


<210>  135
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 300-319

<400>  135

Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Ile Glu Glu 
1               5                   10                  15      


Ala Asn Ser Lys 
            20  


<210>  136
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 312-331

<400>  136

Ala Leu Glu Glu Ala Asn Ser Lys Leu Ala Ala Leu Glu Lys Leu Asn 
1               5                   10                  15      


Lys Glu Leu Glu 
            20  


<210>  137
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 329-359

<400>  137

Glu Leu Glu Glu Ser Lys Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu 
1               5                   10                  15      


Gln Ala Lys Leu Glu Ala Glu Ala Lys Gln Leu Lys Glu Gln Leu 
            20                  25                  30      


<210>  138
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 359-388

<400>  138

Ala Lys Gln Ala Glu Glu Leu Ala Lys Leu Arg Ala Gly Lys Ala Ser 
1               5                   10                  15      


Asp Ser Gln Thr Pro Asp Thr Lys Pro Gly Asn Lys Ala Val 
            20                  25                  30  


<210>  139
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 389-425

<400>  139

Val Pro Gly Lys Gly Gln Ala Pro Gln Ala Gly Thr Lys Pro Asn Gln 
1               5                   10                  15      


Asn Lys Ala Pro Met Lys Glu Thr Lys Arg Gln Leu Pro Ser Thr Gly 
            20                  25                  30          


Glu Thr Ala Asn Pro 
        35          


<210>  140
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 295-313

<400>  140

Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu 
1               5                   10                  15      


Lys Ala Ile 
            


<210>  141
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 305-324

<400>  141

Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Glu Ala Asn Ser Lys Leu 
1               5                   10                  15      


Ala Ala Leu Glu 
            20  


<210>  142
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 335-354

<400>  142

Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys Leu Glu Ala 
1               5                   10                  15      


Glu Ala Lys Ala 
            20  


<210>  143
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 345-364

<400>  143

Gln Ala Lys Leu Glu Ala Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala 
1               5                   10                  15      


Lys Gln Ala Glu 
            20  


<210>  144
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 355-374

<400>  144

Leu Lys Glu Gln Leu Ala Lys Gln Ala Glu Glu Leu Ala Lys Leu Arg 
1               5                   10                  15      


Ala Gly Lys Ala 
            20  


<210>  145
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 1-25

<400>  145

Thr Val Thr Arg Gly Thr Ile Ser Asp Pro Gln Arg Ala Lys Glu Ala 
1               5                   10                  15      


Leu Asp Lys Tyr Glu Leu Glu Asn His 
            20                  25  


<210>  146
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 81-96

<400>  146

Asp Lys Leu Lys Gln Gln Arg Asp Thr Leu Ser Thr Gln Lys Glu Thr 
1               5                   10                  15      


Leu Glu Arg Glu Val Gln Asn Ile 
            20                  


<210>  147
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 163-177

<400>  147

Glu Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys 
1               5                   10                  15  


<210>  148
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 1-18

<400>  148

Ala Val Thr Arg Gly Thr Ile Asn Asp Pro Gln Arg Ala Lys Glu Ala 
1               5                   10                  15      


Leu Asp 
        


<210>  149
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 14-31

<400>  149

Lys Glu Ala Leu Asp Lys Tyr Glu Leu Glu Asn His Asp Leu Lys Thr 
1               5                   10                  15      


Lys Asn 
        


<210>  150
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 27-44

<400>  150

Leu Lys Thr Lys Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys 
1               5                   10                  15      


Thr Glu 
        


<210>  151
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 40-58

<400>  151

Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu 
1               5                   10                  15      


Lys Thr Glu 
            


<210>  152
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 59-76

<400>  152

Lys Lys Glu His Glu Ala Glu Asn Asp Lys Leu Lys Gln Gln Arg Asp 
1               5                   10                  15      


Thr Leu 
        


<210>  153
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 72-89

<400>  153

Gln Arg Asp Thr Leu Ser Thr Gln Lys Glu Thr Leu Glu Arg Glu Val 
1               5                   10                  15      


Gln Asn 
        


<210>  154
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 85-102

<400>  154

Arg Glu Val Gln Asn Thr Gln Tyr Asn Asn Glu Thr Leu Lys Ile Lys 
1               5                   10                  15      


Asn Gly 
        


<210>  155
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 98-115

<400>  155

Lys Ile Lys Asn Gly Asp Leu Thr Lys Glu Leu Asn Lys Thr Arg Gln 
1               5                   10                  15      


Glu Leu 
        


<210>  156
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 111-129

<400>  156

Thr Arg Gln Glu Leu Ala Asn Lys Gln Gln Glu Ser Lys Glu Asn Glu 
1               5                   10                  15      


Lys Ala Leu 
            


<210>  157
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 124-141

<400>  157

Glu Asn Glu Lys Ala Leu Asn Glu Leu Leu Glu Lys Thr Val Lys Asp 
1               5                   10                  15      


Lys Ile 
        


<210>  158
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 137-154

<400>  158

Val Lys Asp Lys Ile Ala Lys Glu Gln Glu Asn Lys Glu Thr Ile Gly 
1               5                   10                  15      


Thr Leu 
        


<210>  159
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 150-167

<400>  159

Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys 
1               5                   10                  15      


Ile Ala 
        


<210>  160
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 163-180

<400>  160

Lys Asp Lys Ile Ala Lys Glu Gln Glu Asn Lys Glu Thr Ile Gly Thr 
1               5                   10                  15      


Leu Lys 
        


<210>  161
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 176-193

<400>  161

Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys Leu 
1               5                   10                  15      


Ala Lys 
        


<210>  162
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 189-206

<400>  162

Asp Lys Leu Ala Lys Glu Gln Lys Ser Lys Gln Asn Ile Gly Ala Leu 
1               5                   10                  15      


Lys Gln 
        


<210>  163
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 202-219

<400>  163

Gly Ala Leu Lys Gln Glu Leu Ala Lys Lys Asp Glu Ala Asn Lys Ile 
1               5                   10                  15      


Ser Asp 
        


<210>  164
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 215-232

<400>  164

Asn Lys Ile Ser Asp Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu Asp 
1               5                   10                  15      


Ala Ser 
        


<210>  165
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 228-245

<400>  165

Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Leu Glu Ala Glu His 
1               5                   10                  15      


Gln Lys 
        


<210>  166
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 241-258

<400>  166

Ala Glu His Gln Lys Leu Glu Glu Gln Asn Lys Ile Ser Glu Ala Ser 
1               5                   10                  15      


Arg Lys 
        


<210>  167
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 254-271

<400>  167

Glu Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu 
1               5                   10                  15      


Ala Lys 
        


<210>  168
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 267-284

<400>  168

Ser Arg Glu Ala Lys Lys Gln Leu Glu Ala Glu Gln Gln Lys Leu Glu 
1               5                   10                  15      


Glu Gln 
        


<210>  169
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 280-297

<400>  169

Lys Leu Glu Glu Gln Asn Lys Ile Ser Glu Ala Ser Arg Lys Gly Leu 
1               5                   10                  15      


Arg Arg 
        


<210>  170
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 epitope protein 293-308

<400>  170

Lys Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln 
1               5                   10                  15      


<210>  171
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thyroglobulin antigen 1


<220>
<221>  X
<222>  (5)..(5)
<223>  Xaa is 3,5,3',5'-tetraiodothyronine (thyroxine)

<400>  171

Asn Ile Phe Glu Xaa Gln Val Asp Ala Gln Pro Leu 
1               5                   10          


<210>  172
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thyroglobulin antigen-2


<220>
<221>  X
<222>  (10)..(10)
<223>  Xaa is 3,5,3',5'-tetraiodothyronine (thyroxine)

<400>  172

Tyr Ser Leu Glu His Ser Thr Asp Asp Xaa Ala Ser Phe Ser Arg Ala 
1               5                   10                  15      


Leu Glu Asn Ala Thr Arg 
            20          


<210>  173
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thyroglobulin antigen-3


<220>
<221>  X
<222>  (10)..(10)
<223>  Xaa is 3,5,3',5'-tetraiodothyronine (thyroxine)

<400>  173

Arg Ala Leu Glu Asn Ala Thr Arg Asp Xaa Phe Ile Ile Cys Pro Ile 
1               5                   10                  15      


Ile Asp Met Ala 
            20  


<210>  174
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thyroglobulin antigen-4


<220>
<221>  X
<222>  (12)..(12)
<223>  Xaa is 3,5,3',5'-tetraiodothyronine (thyroxine)

<400>  174

Leu Leu Ser Leu Gln Glu Pro Gly Ser Lys Thr Xaa Ser Lys 
1               5                   10                  


<210>  175
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thyroglobulin antigen-5


<220>
<221>  X
<222>  (7)..(7)
<223>  Xaa is 3,5,3',5'-tetraiodothyronine (thyroxine)

<400>  175

Glu His Ser Thr Asp Asp Xaa Ala Ser Phe Ser Arg Ala Leu Glu Asn 
1               5                   10                  15      


<210>  176
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-1

<400>  176

Leu Lys Lys Arg Gly Ile Leu Ser Pro Ala Gln Leu Leu Ser 
1               5                   10                  


<210>  177
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-2

<400>  177

Ser Gly Val Ile Ala Arg Ala Ala Glu Ile Met Glu Thr Ser Ile Gln 
1               5                   10                  15      


<210>  178
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-3

<400>  178

Pro Pro Val Arg Glu Val Thr Arg His Val Ile Gln Val Ser 
1               5                   10                  


<210>  179
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-4

<400>  179

Pro Arg Gln Gln Met Asn Gly Leu Thr Ser Phe Leu Asp Ala Ser 
1               5                   10                  15  


<210>  180
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-5

<400>  180

Leu Thr Ala Leu His Thr Leu Trp Leu Arg Glu His Asn Arg Leu 
1               5                   10                  15  


<210>  181
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-6

<400>  181

His Asn Arg Leu Ala Ala Ala Leu Lys Ala Leu Asn Ala His Trp 
1               5                   10                  15  


<210>  182
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-7

<400>  182

Ala Arg Lys Val Val Gly Ala Leu His Gln Ile Ile Thr Leu 
1               5                   10                  


<210>  183
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-7

<400>  183

Leu Pro Gly Leu Trp Leu His Gln Ala Phe Phe Ser Pro Trp Thr Leu 
1               5                   10                  15      


<210>  184
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-8

<400>  184

Met Asn Glu Glu Leu Thr Glu Arg Leu Phe Val Leu Ser Asn Ser Ser 
1               5                   10                  15      


Thr 
    


<210>  185
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-9

<400>  185

Leu Asp Leu Ala Ser Ile Asn Leu Gln Arg Gly 
1               5                   10      


<210>  186
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-10

<400>  186

Arg Ser Val Ala Asp Lys Ile Leu Asp Leu Tyr Lys His Pro Asp Asn 
1               5                   10                  15      


<210>  187
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPO antigen-11

<400>  187

Ile Asp Val Trp Leu Gly Gly Leu Ala Glu Asn Phe Leu Pro 
1               5                   10                  


<210>  188
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 34-44 in human pendrin

<400>  188

Gln Gln Gln His Glu Arg Arg Lys Gln Glu Arg Lys 
1               5                   10          


<210>  189
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 630-643 in human pendrin

<400>  189

Pro Thr Lys Glu Ile Glu Ile Gln Val Asp Trp Asn Ser Glu 
1               5                   10                  


<210>  190
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human S-Antigen Peptide 19

<400>  190

Val Gln His Ala Pro Leu Glu Met Gly Pro Gln Pro Arg Ala Glu Ala 
1               5                   10                  15      


Thr Trp Gln Phe 
            20  


<210>  191
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human S-Antigen Peptide 35

<400>  191

Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala Thr Glu Val Pro 
1               5                   10                  15      


Phe Arg Leu Met 
            20  


<210>  192
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human S-Antigen Peptide 36

<400>  192

Val Ala Thr Glu Val Pro Phe Arg Leu Met His Pro Gln Pro Glu Asp 
1               5                   10                  15      


Pro Ala Lys Glu 
            20  


<210>  193
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IRBP peptide

<400>  193

Tyr Leu Leu Thr Ser His Arg Thr Ala Thr Ala Ala Glu Glu Phe Ala 
1               5                   10                  15      


Phe Leu Met Gln 
            20  


<210>  194
<211>  3512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTERT nucleic acid

<400>  194
ggtaccgaat tcgccaccat ggactggacc tggatcctgt tcctggtggc cgctgccaca       60

agagtgcaca gccccagggc ccccaggtgc agagccgtgc ggagcctgct gcggagccac      120

taccgggagg tgctgcccct ggccaccttc gtgcggaggc tgggccctca ggggtggcgg      180

ctggtgcaga gaggcgaccc tgccgccttc agagccctgg tggcccagtg cctggtgtgc      240

gtgccctggg acgccagacc tccccctgcc gcccctagct tccggcaggt gtcctgcctg      300

aaagaactgg tggcccgggt gctgcagcgg ctgtgcgaga ggggcgccaa gaacgtgctg      360

gccttcggct tcgccctgct ggacggcgcc agaggcggcc ctcccgaggc cttcaccacc      420

tccgtgagaa gctacctgcc caacaccgtg accgacgccc tgagaggcag cggcgcttgg      480

ggcctgctgc tgcgcagagt gggcgacgac gtgctggtgc acctgctggc cagatgcgcc      540

ctgttcgtgc tggtcgcccc cagctgcgcc taccaggtgt gcggcccacc cctgtaccag      600

ctgggagccg ccacccaggc cagaccccct cctcacgcct ccggccccag gcggagactg      660

ggctgcgagc gggcctggaa ccacagcgtg cgggaggccg gcgtgcccct gggcctgcca      720

gcccctggcg ccagaagaag gggcggcagc gccagcagaa gcctgcccct gcccaagcgg      780

cccagacgcg gagccgcccc tgagcccgag agaacccccg tgggccaggg ctcttgggcc      840

caccctggcc ggaccagagg ccccagcgac cggggcttct gcgtggtgtc ccccgccaga      900

cccgccgagg aagccacctc cctggaaggc gccctgagcg gcaccaggca cagccacccc      960

agcgtgggcc gccagcacca cgccggaccc cccagcacct ccaggccccc caggccctgg     1020

gacacccctt gcccccctgt gtacgccgag accaagcact tcctgtacag cagcggcgac     1080

aaagagcagc tgcggcccag cttcctgctg tccagcctga ggccctccct gaccggcgct     1140

aggcgcctgg tggagaccat ctttctgggc agccggccct ggatgcccgg cacccccagg     1200

cggctgccca ggctgcccca gcggtactgg cagatgaggc ctctgttcct ggaactgctg     1260

ggcaaccacg cccagtgccc ctacggcgtg ctgctgaaaa cccactgccc cctgagagcc     1320

gccgtgaccc cagccgccgg agtgtgcgcc agagagaagc ctcagggcag cgtggccgct     1380

cccgaggaag aggacaccga ccccagacgc ctggtgcagc tgctgcggca gcacagcagc     1440

ccttggcagg tgtacggctt cgtgcgggcc tgcctgagaa ggctggtgcc ccctggcctg     1500

tggggcagca ggcacaacga gcggcggttt ctgcggaaca ccaagaagtt catcagcctg     1560

gggaagcacg ccaagctgtc cctgcaggaa ctgacctgga agatgagcgt gcggggctgc     1620

gcctggctga gaagatcccc tggcgtgggc tgcgtgcctg ccgccgagca ccggctgcgg     1680

gaggaaatcc tggccaagtt cctgcactgg ctgatgagcg tgtacgtggt ggagctgctg     1740

agatccttct tctacgtgac cgagaccacc ttccagaaga actacctgtt cttctaccgg     1800

aagagcgtgt ggagcaagct gcagagcatc ggcatccggc agcacctgaa gcgggtgcag     1860

ctgagagagc tgtccgaggc cgaagtgagg cagcaccggg aggccagacc tgccctgctg     1920

accagccggc tgcggttcat ccccaagccc gacggcctgc ggcccatcgt gaacatggac     1980

tacgtggtgg gcgccaggac cttccggcgg gagaagcggg ccgagcggct gacctcgagg     2040

gtgaaggccc tgttcagcgt gctgaactac gagcgggcca ggcggccagg cctgctgggc     2100

gccagcgtgc tgggcctgga cgacatccac cgggcctggc ggaccttcgt gctgagagtg     2160

cgggcccagg acccccctcc cgagctgtac ttcgtgaagg tggacgtgac aggcgcctac     2220

gacaccatcc cccaggaccg gctgaccgag gtgatcgcca gcatcatcaa gccccagaac     2280

acctactgcg tgcggagata cgccgtggtg cagaaggccg cccacggcca cgtgcggaag     2340

gccttcaaga gccacgtgag caccctgacc gacctgcagc cctacatgcg gcagttcgtg     2400

gcccacctgc aggaaaccag ccccctgcgg gatgccgtgg tgatcgagca gagcagcagc     2460

ctgaacgagg ccagcagcgg cctgttcgac gtgttcctga gattcatgtg ccaccacgcc     2520

gtgcggatcc ggggcaagag ctacgtgcag tgccagggca tcccacaggg cagcatcctg     2580

tccaccctgc tgtgctccct gtgctacggc gacatggaaa acaagctgtt cgccggcatc     2640

aggcgggacg gactgctgct gagactggtg gacgacttcc tgctggtgac cccccacctg     2700

acccacgcca agacctttct gcggaccctg gtgcgcggcg tgcccgagta cggctgcgtg     2760

gtgaacctga gaaagaccgt ggtgaacttc cccgtggagg acgaggccct gggcggcaca     2820

gccttcgtgc agatgcctgc ccatggactg ttcccttggt gcgggctgct gctggacacc     2880

cggaccctgg aagtgcagag cgactacagc agctacgccc ggaccagcat ccgggcctcc     2940

ctgaccttca acaggggctt caaggccggc aggaacatgc ggcggaagct gtttggcgtg     3000

ctgcggctga agtgccacag cctgtttctg tacctgcagg tgaacagcct gcagaccgtg     3060

tgcaccaaca tctacaagat cctgctgctg caggcctacc ggttccacgc ctgcgtgctg     3120

cagctgccct ttcaccagca ggtgtggaag aaccctacct tcttcctgcg ggtgatcagc     3180

gacaccgcca gcctgtgcta cagcatcctg aaggccaaga acgccggcat gagcctgggc     3240

gccaagggag ccgccggacc tctgcccagc gaggccgtgc agtggctgtg ccaccaggcc     3300

tttctgctga agctgacccg gcaccgggtg acctacgtgc ccctgctggg cagcctgcgg     3360

accgcccaga cccagctgtc ccggaagctg cctggcacca ccctgacagc cctggaagcc     3420

gccgccaacc ccgccctgcc ctccgacttc aagaccatcc tggactaccc ctacgacgtg     3480

cccgactacg cctgatgagc ggccgcgagc tc                                   3512


<210>  195
<211>  1158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTERT amino acid sequence

<400>  195

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg 
            20                  25                  30          


Ser His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu 
        35                  40                  45              


Gly Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe 
    50                  55                  60                  


Arg Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg 
65                  70                  75                  80  


Pro Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu 
                85                  90                  95      


Leu Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn 
            100                 105                 110         


Val Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val 
    130                 135                 140                 


Thr Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg 
145                 150                 155                 160 


Val Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe 
                165                 170                 175     


Val Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu 
            180                 185                 190         


Tyr Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser 
        195                 200                 205             


Gly Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val 
    210                 215                 220                 


Arg Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg 
225                 230                 235                 240 


Arg Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg 
                245                 250                 255     


Arg Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser 
            260                 265                 270         


Trp Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys 
        275                 280                 285             


Val Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly 
    290                 295                 300                 


Ala Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His 
305                 310                 315                 320 


His Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr 
                325                 330                 335     


Pro Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser 
            340                 345                 350         


Gly Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg 
        355                 360                 365             


Pro Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly 
    370                 375                 380                 


Ser Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro 
385                 390                 395                 400 


Gln Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn 
                405                 410                 415     


His Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu 
            420                 425                 430         


Arg Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro 
        435                 440                 445             


Gln Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg 
    450                 455                 460                 


Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly 
465                 470                 475                 480 


Phe Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly 
                485                 490                 495     


Ser Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile 
            500                 505                 510         


Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys 
        515                 520                 525             


Met Ser Val Arg Gly Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly 
    530                 535                 540                 


Cys Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys 
545                 550                 555                 560 


Phe Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser 
                565                 570                 575     


Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Tyr Leu Phe Phe 
            580                 585                 590         


Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln 
        595                 600                 605             


His Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg 
    610                 615                 620                 


Gln His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe 
625                 630                 635                 640 


Ile Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val 
                645                 650                 655     


Val Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr 
            660                 665                 670         


Ser Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg 
        675                 680                 685             


Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His 
    690                 695                 700                 


Arg Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro 
705                 710                 715                 720 


Pro Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr 
                725                 730                 735     


Ile Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro 
            740                 745                 750         


Gln Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala 
        755                 760                 765             


His Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr 
    770                 775                 780                 


Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr 
785                 790                 795                 800 


Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn 
                805                 810                 815     


Glu Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His 
            820                 825                 830         


His Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile 
        835                 840                 845             


Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly 
    850                 855                 860                 


Asp Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu 
865                 870                 875                 880 


Leu Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His 
                885                 890                 895     


Ala Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly 
            900                 905                 910         


Cys Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp 
        915                 920                 925             


Glu Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu 
    930                 935                 940                 


Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln 
945                 950                 955                 960 


Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                965                 970                 975     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            980                 985                 990         


Gly Val Leu Arg Leu Lys Cys His  Ser Leu Phe Leu Tyr  Leu Gln Val 
        995                 1000                 1005             


Asn Ser  Leu Gln Thr Val Cys  Thr Asn Ile Tyr Lys  Ile Leu Leu 
    1010                 1015                 1020             


Leu Gln  Ala Tyr Arg Phe His  Ala Cys Val Leu Gln  Leu Pro Phe 
    1025                 1030                 1035             


His Gln  Gln Val Trp Lys Asn  Pro Thr Phe Phe Leu  Arg Val Ile 
    1040                 1045                 1050             


Ser Asp  Thr Ala Ser Leu Cys  Tyr Ser Ile Leu Lys  Ala Lys Asn 
    1055                 1060                 1065             


Ala Gly  Met Ser Leu Gly Ala  Lys Gly Ala Ala Gly  Pro Leu Pro 
    1070                 1075                 1080             


Ser Glu  Ala Val Gln Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys 
    1085                 1090                 1095             


Leu Thr  Arg His Arg Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu 
    1100                 1105                 1110             


Arg Thr  Ala Gln Thr Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr 
    1115                 1120                 1125             


Leu Thr  Ala Leu Glu Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp 
    1130                 1135                 1140             


Phe Lys  Thr Ile Leu Asp Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1145                 1150                 1155             


<210>  196
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSA antigen 1 nucleic acid

<400>  196
atgtgggtcc tggtggtgtt cctgactctg agcgtcacat ggatcggcgc cgctccactg       60

attctgagcc gcctggtggg cgggtgggag tgcgaaaagc actcccagcc atggcaggtg      120

ctggtcgctt ctaggggccg agcagtgtgc ggaggcgtgc tggtccaccc tcagtgggtc      180

ctgaccgcag cccattgtat ccgacagaag agcgtgattc tgctggggcg acaccagcca      240

ttctaccccg aggacacagg acaggtgttc caggtctctc acagttttcc ccatcctctg      300

tacaacatga gcctgctgaa aaacagatat ctgggacctg gcgacgatag ctcccatgat      360

ctgatgctgc tgaggctgtc cgagccagcc gaactgactg acgctgtgca ggtcctggat      420

ctgcccaccc aggagcctgc cctgggaacc acatgttatg cttcaggctg ggggagcatc      480

gaaccagagg aacatctgac tcccaagaaa ctgcagtgcg tggacctgca cctgattagt      540

aacgatgtgt gtgcacaggt ccattcacag aaggtgacaa agttcatgct gtgcgccggc      600

tcttggatgg gcggcaagtc aacttgcagc ggggactccg gcgggccact ggtgtgtgat      660

ggagtcctgc agggcatcac ctcttggggc agtcagcctt gtgccctgcc tcggagacca      720

agtctgtaca ctaaggtggt ccggtatagg aaatggattc aggacactat tgccgctaac      780

ccctgataa                                                              789


<210>  197
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSA antigen 1 amino acid

<400>  197

Met Trp Val Leu Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Leu Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Gln Lys Ser Val Ile Leu Leu Gly Arg His Gln Pro 
65                  70                  75                  80  


Phe Tyr Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys Asn Arg Tyr Leu Gly 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Gln Val Leu Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu His Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Leu Ile Ser Asn Asp Val Cys Ala Gln Val His Ser Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Ser Trp Met Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Gln Pro Cys Ala Leu Pro Arg Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val Arg Tyr Arg Lys Trp Ile Gln Asp Thr 
                245                 250                 255     


Ile Ala Ala Asn Pro 
            260     


<210>  198
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSA antigen 2 nucliec acid

<400>  198
atggactgga catggattct gttcctggtc gccgccgcaa ctcgcgtgca ttcctgggtc       60

ctggtggtgt tcctgactct gagcgtcaca tggatcggcg ccgctccact gattctgagc      120

cgcctggtgg gcgggtggga gtgcgaaaag cactcccagc catggcaggt gctggtcgct      180

tctaggggcc gagcagtgtg cggaggcgtg ctggtccacc ctcagtgggt cctgaccgca      240

gcccattgta tccgacagaa gagcgtgatt ctgctggggc gacaccagcc attctacccc      300

gaggacacag gacaggtgtt ccaggtctct cacagttttc cccatcctct gtacaacatg      360

agcctgctga aaaacagata tctgggacct ggcgacgata gctcccatga tctgatgctg      420

ctgaggctgt ccgagccagc cgaactgact gacgctgtgc aggtcctgga tctgcccacc      480

caggagcctg ccctgggaac cacatgttat gcttcaggct gggggagcat cgaaccagag      540

gaacatctga ctcccaagaa actgcagtgc gtggacctgc acctgattag taacgatgtg      600

tgtgcacagg tccattcaca gaaggtgaca aagttcatgc tgtgcgccgg ctcttggatg      660

ggcggcaagt caacttgcag cggggactcc ggcgggccac tggtgtgtga tggagtcctg      720

cagggcatca cctcttgggg cagtcagcct tgtgccctgc ctcggagacc aagtctgtac      780

actaaggtgg tccggtatag gaaatggatt caggacacta ttgccgctaa cccctgataa      840


<210>  199
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSA antigen 2 amino acid

<400>  199

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Trp Val Leu Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile 
            20                  25                  30          


Gly Ala Ala Pro Leu Ile Leu Ser Arg Leu Val Gly Gly Trp Glu Cys 
        35                  40                  45              


Glu Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg 
    50                  55                  60                  


Ala Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala 
65                  70                  75                  80  


Ala His Cys Ile Arg Gln Lys Ser Val Ile Leu Leu Gly Arg His Gln 
                85                  90                  95      


Pro Phe Tyr Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser 
            100                 105                 110         


Phe Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys Asn Arg Tyr Leu 
        115                 120                 125             


Gly Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser 
    130                 135                 140                 


Glu Pro Ala Glu Leu Thr Asp Ala Val Gln Val Leu Asp Leu Pro Thr 
145                 150                 155                 160 


Gln Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser 
                165                 170                 175     


Ile Glu Pro Glu Glu His Leu Thr Pro Lys Lys Leu Gln Cys Val Asp 
            180                 185                 190         


Leu His Leu Ile Ser Asn Asp Val Cys Ala Gln Val His Ser Gln Lys 
        195                 200                 205             


Val Thr Lys Phe Met Leu Cys Ala Gly Ser Trp Met Gly Gly Lys Ser 
    210                 215                 220                 


Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Val Leu 
225                 230                 235                 240 


Gln Gly Ile Thr Ser Trp Gly Ser Gln Pro Cys Ala Leu Pro Arg Arg 
                245                 250                 255     


Pro Ser Leu Tyr Thr Lys Val Val Arg Tyr Arg Lys Trp Ile Gln Asp 
            260                 265                 270         


Thr Ile Ala Ala Asn Pro 
        275             


<210>  200
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA antigen 1 nucleic acid

<400>  200
atgtggaacg cactgcatga gactgattct gctgtcgcac tgggacggag accccggtgg       60

ctgtgcgctg gagcactggt gctggccggc gggggattcc tgctgggatt cctgtttggc      120

tggtttatca aaagctccag cgaggctacc aatattaccc ctaagcacaa taagaaagca      180

ttcctggatg aactgaaagc cgagaacatc aagaaattcc tgtacaactt cacaagaatt      240

ccacatctgg ctggcactga gcagaacttc cagctggcaa aacagatcca gagtcagtgg      300

aaggaatttg ggctggactc agtggagctg acccactacg atgtcctgct gtcctatcca      360

aataagactc atcccaacta catctctatc attaacgaag acggaaatga gattttcaac      420

acctctctgt ttgaaccccc tccacccggc tatgagaatg tcagtgacgt ggtccctcca      480

ttctcagcct tcagccccca ggggatgcct gagggagatc tggtgtacgt caattatgct      540

agaacagaag acttctttaa gctggagagg gatatgaaaa tcaactgttc cggcaagatc      600

gtgattgccc ggtacgggaa ggtgttcaga ggaaataagg tcaaaaacgc tcagctggcc      660

ggagctaccg gcgtgatcct gtacagcgac cccgctgatt attttgcacc tggcgtgaag      720

tcctatccag acggatggaa tctgcccggc gggggagtgc agaggggaaa catcctgaac      780

ctgaatggag ccggcgatcc tctgactcca ggataccccg ccaacgaata cgcttatcgc      840

cggggaattg cagaggccgt gggcctgcct agcatcccag tccatcccat tggctattac      900

gatgcccaga agctgctgga gaaaatgggc gggagcgctc cccctgactc tagttggaag      960

ggctccctga aagtgcctta caatgtcggg ccaggattca ctgggaactt ttctacccag     1020

aaggtgaaaa tgcacatcca tagtaccagc gaggtgacac gaatctacaa cgtcattggc     1080

accctgagag gcgccgtgga gcctgatcgc tatgtcattc tgggaggcca cagagactca     1140

tgggtgttcg ggggaatcga tccacagagc ggagcagctg tggtccatga aattgtgcgc     1200

agctttggga ccctgaagaa agagggatgg cgacccaggc gcacaatcct gttcgcatcc     1260

tgggacgccg aggaatttgg gctgctgggc agcacagaat gggccgagga aaattctcgc     1320

ctgctgcagg agcgaggggt ggcttacatc aatgcagact caagcattga aggaaactat     1380

accctgcggg tggattgcac acccctgatg tacagtctgg tctataacct gacaaaggag     1440

ctgaaatcac ctgacgaggg cttcgaaggg aaaagcctgt acgaatcctg gactgagaag     1500

agcccatccc ccgaattcag cggcatgcct aggatctcta agctgggcag tgggaacgat     1560

tttgaggtgt tctttcagcg cctgggaatt gcctctggcc gagctcggta cacaaaaaat     1620

tgggagacta acaagttctc ctcttaccca ctgtatcaca gcgtgtacga gacttatgaa     1680

ctggtcgaga aattctacga ccccactttt aagtatcatc tgaccgtggc acaggtcagg     1740

ggcgggatgg tgttcgaact ggccaatagc atcgtcctgc catttgactg tcgagattac     1800

gctgtggtcc tgcggaagta cgcagacaag atctataaca tctccatgaa gcacccccag     1860

gagatgaagg cctattctgt gagtttcgat tccctgtttt ctgccgtcaa aaatttcacc     1920

gaaatcgcta gtaagttttc agagcgcctg caggacctgg ataagtccaa tcccatcctg     1980

ctgcggatta tgaacgatca gctgatgttc ctggaaagag cctttatcga ccctctgggc     2040

ctgcctgata gaccattcta caggcacgtg atctacgcac ctagttcaca taacaagtac     2100

gccggcgagt ctttcccagg gatctatgac gctctgtttg atattgaatc aaaggtggac     2160

cccagcaaag catggggcga ggtcaagaga cagatcagca ttgcagcctt tacagtgcag     2220

gccgccgccg aaaccctgtc cgaagtcgct tacccatacg atgtccccga ttacgcatga     2280

taa                                                                   2283


<210>  201
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA antigen 1 amino acid

<400>  201

Met Trp Asn Ala Leu His Glu Thr Asp Ser Ala Val Ala Leu Gly Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Gly 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Ser Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Lys Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Arg Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Thr His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Val Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Thr Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Lys 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Ser Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val Tyr Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Glu Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Ser Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Thr Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Asn Ile Ser Met Lys His Pro Gln Glu Met Lys Ala 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Leu Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Leu Leu Arg Ile Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Ser Ile Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  202
<211>  2334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA antigen 2 nucleic acid

<400>  202
atggactgga catggattct gttcctggtc gccgccgcaa ctcgcgtgca ttcctggaac       60

gcactgcatg agactgattc tgctgtcgca ctgggacgga gaccccggtg gctgtgcgct      120

ggagcactgg tgctggccgg cgggggattc ctgctgggat tcctgtttgg ctggtttatc      180

aaaagctcca gcgaggctac caatattacc cctaagcaca ataagaaagc attcctggat      240

gaactgaaag ccgagaacat caagaaattc ctgtacaact tcacaagaat tccacatctg      300

gctggcactg agcagaactt ccagctggca aaacagatcc agagtcagtg gaaggaattt      360

gggctggact cagtggagct gacccactac gatgtcctgc tgtcctatcc aaataagact      420

catcccaact acatctctat cattaacgaa gacggaaatg agattttcaa cacctctctg      480

tttgaacccc ctccacccgg ctatgagaat gtcagtgacg tggtccctcc attctcagcc      540

ttcagccccc aggggatgcc tgagggagat ctggtgtacg tcaattatgc tagaacagaa      600

gacttcttta agctggagag ggatatgaaa atcaactgtt ccggcaagat cgtgattgcc      660

cggtacggga aggtgttcag aggaaataag gtcaaaaacg ctcagctggc cggagctacc      720

ggcgtgatcc tgtacagcga ccccgctgat tattttgcac ctggcgtgaa gtcctatcca      780

gacggatgga atctgcccgg cgggggagtg cagaggggaa acatcctgaa cctgaatgga      840

gccggcgatc ctctgactcc aggatacccc gccaacgaat acgcttatcg ccggggaatt      900

gcagaggccg tgggcctgcc tagcatccca gtccatccca ttggctatta cgatgcccag      960

aagctgctgg agaaaatggg cgggagcgct ccccctgact ctagttggaa gggctccctg     1020

aaagtgcctt acaatgtcgg gccaggattc actgggaact tttctaccca gaaggtgaaa     1080

atgcacatcc atagtaccag cgaggtgaca cgaatctaca acgtcattgg caccctgaga     1140

ggcgccgtgg agcctgatcg ctatgtcatt ctgggaggcc acagagactc atgggtgttc     1200

gggggaatcg atccacagag cggagcagct gtggtccatg aaattgtgcg cagctttggg     1260

accctgaaga aagagggatg gcgacccagg cgcacaatcc tgttcgcatc ctgggacgcc     1320

gaggaatttg ggctgctggg cagcacagaa tgggccgagg aaaattctcg cctgctgcag     1380

gagcgagggg tggcttacat caatgcagac tcaagcattg aaggaaacta taccctgcgg     1440

gtggattgca cacccctgat gtacagtctg gtctataacc tgacaaagga gctgaaatca     1500

cctgacgagg gcttcgaagg gaaaagcctg tacgaatcct ggactgagaa gagcccatcc     1560

cccgaattca gcggcatgcc taggatctct aagctgggca gtgggaacga ttttgaggtg     1620

ttctttcagc gcctgggaat tgcctctggc cgagctcggt acacaaaaaa ttgggagact     1680

aacaagttct cctcttaccc actgtatcac agcgtgtacg agacttatga actggtcgag     1740

aaattctacg accccacttt taagtatcat ctgaccgtgg cacaggtcag gggcgggatg     1800

gtgttcgaac tggccaatag catcgtcctg ccatttgact gtcgagatta cgctgtggtc     1860

ctgcggaagt acgcagacaa gatctataac atctccatga agcaccccca ggagatgaag     1920

gcctattctg tgagtttcga ttccctgttt tctgccgtca aaaatttcac cgaaatcgct     1980

agtaagtttt cagagcgcct gcaggacctg gataagtcca atcccatcct gctgcggatt     2040

atgaacgatc agctgatgtt cctggaaaga gcctttatcg accctctggg cctgcctgat     2100

agaccattct acaggcacgt gatctacgca cctagttcac ataacaagta cgccggcgag     2160

tctttcccag ggatctatga cgctctgttt gatattgaat caaaggtgga ccccagcaaa     2220

gcatggggcg aggtcaagag acagatcagc attgcagcct ttacagtgca ggccgccgcc     2280

gaaaccctgt ccgaagtcgc ttacccatac gatgtccccg attacgcatg ataa           2334


<210>  203
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA antigen 2 amino acid

<400>  203

Met Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His 
1               5                   10                  15      


Ser Trp Asn Ala Leu His Glu Thr Asp Ser Ala Val Ala Leu Gly Arg 
            20                  25                  30          


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Gly 
        35                  40                  45              


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Ser Glu 
    50                  55                  60                  


Ala Thr Asn Ile Thr Pro Lys His Asn Lys Lys Ala Phe Leu Asp Glu 
65                  70                  75                  80  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Arg Ile 
                85                  90                  95      


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
            100                 105                 110         


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Thr His 
        115                 120                 125             


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
    130                 135                 140                 


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
145                 150                 155                 160 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Val Val Pro Pro 
                165                 170                 175     


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
            180                 185                 190         


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
        195                 200                 205             


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
    210                 215                 220                 


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Thr Gly 
225                 230                 235                 240 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
                245                 250                 255     


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
            260                 265                 270         


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
        275                 280                 285             


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
    290                 295                 300                 


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
305                 310                 315                 320 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Lys 
                325                 330                 335     


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
            340                 345                 350         


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Ser Glu Val 
        355                 360                 365             


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
    370                 375                 380                 


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
385                 390                 395                 400 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
                405                 410                 415     


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
            420                 425                 430         


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
        435                 440                 445             


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
    450                 455                 460                 


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
465                 470                 475                 480 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val Tyr Asn Leu Thr Lys Glu 
                485                 490                 495     


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
            500                 505                 510         


Trp Thr Glu Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
        515                 520                 525             


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
    530                 535                 540                 


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
545                 550                 555                 560 


Lys Phe Ser Ser Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
                565                 570                 575     


Leu Val Glu Lys Phe Tyr Asp Pro Thr Phe Lys Tyr His Leu Thr Val 
            580                 585                 590         


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
        595                 600                 605             


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
    610                 615                 620                 


Asp Lys Ile Tyr Asn Ile Ser Met Lys His Pro Gln Glu Met Lys Ala 
625                 630                 635                 640 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
                645                 650                 655     


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Leu Asp Lys Ser 
            660                 665                 670         


Asn Pro Ile Leu Leu Arg Ile Met Asn Asp Gln Leu Met Phe Leu Glu 
        675                 680                 685             


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
    690                 695                 700                 


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
705                 710                 715                 720 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
                725                 730                 735     


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Ser Ile Ala Ala 
            740                 745                 750         


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
        755                 760                 765     


<210>  204
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STEAP antigen 1 nucleic acid

<400>  204
atggagagcc gcaaggacat cacaaatcag gaagagctgt ggaagatgaa accacggaga       60

aacctggagg aagacgatta cctgcacaag gacaccggcg aaacaagtat gctgaaaaga      120

ccagtgctgc tgcacctgca tcagactgct catgcagacg agtttgattg cccctctgaa      180

ctgcagcaca cccaggagct gttcccacag tggcatctgc ccatcaagat tgccgctatc      240

attgcttcac tgacatttct gtatactctg ctgagagaag tgatccaccc tctggccacc      300

agccatcagc agtacttcta taagatccct attctggtca tcaacaaggt cctgccaatg      360

gtgagcatca cactgctggc cctggtctac ctgcctggcg tgatcgcagc cattgtccag      420

ctgcacaacg gaacaaagta caagaagttc ccacattggc tggataagtg gatgctgact      480

aggaaacagt tcgggctgct gtccttcttt ttcgccgtgc tgcacgctat ctacagcctg      540

tcctatccca tgaggcgctc ttaccgatat aagctgctga actgggctta ccagcaggtg      600

cagcagaaca aggaggacgc atggattgaa cacgatgtgt ggcggatgga aatctatgtg      660

tctctgggca ttgtcgggct ggccatcctg gctctgctgg cagtgaccag tatcccttct      720

gtcagtgact cactgacatg gcgcgagttt cactacattc agagcaagct gggaatcgtg      780

tccctgctgc tgggcaccat ccatgcactg atttttgcct ggaataagtg gatcgatatc      840

aagcagttcg tgtggtatac tccccctacc tttatgattg ccgtcttcct gcccatcgtg      900

gtcctgattt ttaagtccat cctgttcctg ccttgtctgc gaaagaaaat cctgaaaatc      960

cgacatgggt gggaagacgt gacaaaaatc aataagaccg aaatctcaag ccagctgtga     1020

taa                                                                   1023


<210>  205
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STEAP antigen 1 amino acid

<400>  205

Met Glu Ser Arg Lys Asp Ile Thr Asn Gln Glu Glu Leu Trp Lys Met 
1               5                   10                  15      


Lys Pro Arg Arg Asn Leu Glu Glu Asp Asp Tyr Leu His Lys Asp Thr 
            20                  25                  30          


Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu His Gln 
        35                  40                  45              


Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His Thr 
    50                  55                  60                  


Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala Ile 
65                  70                  75                  80  


Ile Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile His 
                85                  90                  95      


Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu 
            100                 105                 110         


Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala Leu 
        115                 120                 125             


Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Leu His Asn Gly 
    130                 135                 140                 


Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu Thr 
145                 150                 155                 160 


Arg Lys Gln Phe Gly Leu Leu Ser Phe Phe Phe Ala Val Leu His Ala 
                165                 170                 175     


Ile Tyr Ser Leu Ser Tyr Pro Met Arg Arg Ser Tyr Arg Tyr Lys Leu 
            180                 185                 190         


Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala Trp 
        195                 200                 205             


Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile 
    210                 215                 220                 


Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser 
225                 230                 235                 240 


Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ser Lys 
                245                 250                 255     


Leu Gly Ile Val Ser Leu Leu Leu Gly Thr Ile His Ala Leu Ile Phe 
            260                 265                 270         


Ala Trp Asn Lys Trp Ile Asp Ile Lys Gln Phe Val Trp Tyr Thr Pro 
        275                 280                 285             


Pro Thr Phe Met Ile Ala Val Phe Leu Pro Ile Val Val Leu Ile Phe 
    290                 295                 300                 


Lys Ser Ile Leu Phe Leu Pro Cys Leu Arg Lys Lys Ile Leu Lys Ile 
305                 310                 315                 320 


Arg His Gly Trp Glu Asp Val Thr Lys Ile Asn Lys Thr Glu Ile Ser 
                325                 330                 335     


Ser Gln Leu 
            


<210>  206
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STEAP antigen 2 nucleic acid

<400>  206
atggactgga catggattct gtttctggtc gctgccgcaa cccgcgtgca ttcagagagc       60

cgcaaggaca tcacaaatca ggaagagctg tggaagatga aaccacggag aaacctggag      120

gaagacgatt acctgcacaa ggacaccggc gaaacaagta tgctgaaaag accagtgctg      180

ctgcacctgc atcagactgc tcatgcagac gagtttgatt gcccctctga actgcagcac      240

acccaggagc tgttcccaca gtggcatctg cccatcaaga ttgccgctat cattgcttca      300

ctgacatttc tgtatactct gctgagagaa gtgatccacc ctctggccac cagccatcag      360

cagtacttct ataagatccc tattctggtc atcaacaagg tcctgccaat ggtgagcatc      420

acactgctgg ccctggtcta cctgcctggc gtgatcgcag ccattgtcca gctgcacaac      480

ggaacaaagt acaagaagtt cccacattgg ctggataagt ggatgctgac taggaaacag      540

ttcgggctgc tgtccttctt tttcgccgtg ctgcacgcta tctacagcct gtcctatccc      600

atgaggcgct cttaccgata taagctgctg aactgggctt accagcaggt gcagcagaac      660

aaggaggacg catggattga acacgatgtg tggcggatgg aaatctatgt gtctctgggc      720

attgtcgggc tggccatcct ggctctgctg gcagtgacca gtatcccttc tgtcagtgac      780

tcactgacat ggcgcgagtt tcactacatt cagagcaagc tgggaatcgt gtccctgctg      840

ctgggcacca tccatgcact gatttttgcc tggaataagt ggatcgatat caagcagttc      900

gtgtggtata ctccccctac ctttatgatt gccgtcttcc tgcccatcgt ggtcctgatt      960

tttaagtcca tcctgttcct gccttgtctg cgaaagaaaa tcctgaaaat ccgacatggg     1020

tgggaagacg tgacaaaaat caataagacc gaaatctcaa gccagctgtg ataa           1074


<210>  207
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STEAP antigen 2 amino acid

<400>  207

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Ser Arg Lys Asp Ile Thr Asn Gln Glu Glu Leu Trp Lys 
            20                  25                  30          


Met Lys Pro Arg Arg Asn Leu Glu Glu Asp Asp Tyr Leu His Lys Asp 
        35                  40                  45              


Thr Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu His 
    50                  55                  60                  


Gln Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His 
65                  70                  75                  80  


Thr Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala 
                85                  90                  95      


Ile Ile Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile 
            100                 105                 110         


His Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile 
        115                 120                 125             


Leu Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala 
    130                 135                 140                 


Leu Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Leu His Asn 
145                 150                 155                 160 


Gly Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu 
                165                 170                 175     


Thr Arg Lys Gln Phe Gly Leu Leu Ser Phe Phe Phe Ala Val Leu His 
            180                 185                 190         


Ala Ile Tyr Ser Leu Ser Tyr Pro Met Arg Arg Ser Tyr Arg Tyr Lys 
        195                 200                 205             


Leu Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala 
    210                 215                 220                 


Trp Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly 
225                 230                 235                 240 


Ile Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro 
                245                 250                 255     


Ser Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ser 
            260                 265                 270         


Lys Leu Gly Ile Val Ser Leu Leu Leu Gly Thr Ile His Ala Leu Ile 
        275                 280                 285             


Phe Ala Trp Asn Lys Trp Ile Asp Ile Lys Gln Phe Val Trp Tyr Thr 
    290                 295                 300                 


Pro Pro Thr Phe Met Ile Ala Val Phe Leu Pro Ile Val Val Leu Ile 
305                 310                 315                 320 


Phe Lys Ser Ile Leu Phe Leu Pro Cys Leu Arg Lys Lys Ile Leu Lys 
                325                 330                 335     


Ile Arg His Gly Trp Glu Asp Val Thr Lys Ile Asn Lys Thr Glu Ile 
            340                 345                 350         


Ser Ser Gln Leu 
        355     


<210>  208
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSCA antigen  nucleic acid

<400>  208
atggactgga catggattct gtttctggtc gccgccgcaa cccgcgtgca ttctgctggc       60

ctggcactgc agcctggaac cgccctgctg tgctactctt gtaaggccca ggtgagtaac      120

gaggactgcc tgcaggtcga aaattgtact cagctgggag agcagtgctg gaccgcacgg      180

atcagagcag tgggactgct gacagtcatt agcaaagggt gctccctgaa ctgtgtggac      240

gatagccagg attactatgt cggaaagaaa aacatcacct gctgtgacac agatctgtgt      300

aatgcttctg gcgcccacgc tctgcagccc gcagccgcta ttctggctct gctgcccgct      360

ctgggactgc tgctgtgggg acccggacag ctgtgataa                             399


<210>  209
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA antigen amino acid

<400>  209

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr 
            20                  25                  30          


Ser Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn 
        35                  40                  45              


Cys Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val 
    50                  55                  60                  


Gly Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp 
65                  70                  75                  80  


Asp Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp 
                85                  90                  95      


Thr Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala 
            100                 105                 110         


Ala Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro 
        115                 120                 125             


Gly Gln Leu 
    130     


<210>  210
<211>  2916
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype A and consensus C3 amino acid

<400>  210
atgctgaacg gcgactggaa ggccaaggtg cagcgcaagc tgaagggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaccaacac ccagaacaac      240

gactggttca gcaagctggc cagcagcgcc ttcaccggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgcaacggc      360

cacaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacag caccaccgag      420

gaccacgtgg ccggccccaa caccagcggc ctggagaccc gcgtggtgca ggccgagcgc      480

ttcttcaaga agttcctgtt cgactggacc accgacaagc ccttcggcca cctgcacaag      540

ctggagctgc ccaccgacca ccacggcgtg ttcggccacc tggtggacag ctacgcctac      600

atgcgcaacg gctgggacgt ggaggtgagc gccgtgggca accagttcaa cggcggctgc      660

ctgctggtgg ccatggtgcc cgagtggaag gagttcgaca cccgcgagaa gtaccagctg      720

accctgttcc cccaccagtt catcagcccc cgcaccaaca tgaccgccca catcaccgtg      780

ccctacctgg gcgtgaaccg ctacgaccag tacaagaagc acaagccctg gaccctggtg      840

gtgatggtgg tgagccccct gaccgtgaac accgccgccc agatcaaggt gtacgccaac      900

atcgccccca cctacgtgca cgtggccggc gagctgccca gcaaggaggg catcttcccc      960

gtggcctgcg ccgacggcta cggcggcctg gtgaccaccg accccaagac cgccgacccc     1020

gcctacggca aggtgtacaa ccccccccgc accaactacc ccggccgctt caccaacctg     1080

ctggacgtgg ccgaggcctg ccccaccttc ctgtgcttcg acgacggcaa gccctacgtg     1140

accacccgca ccgacgagac ccgcctgctg gccaagttcg acgtgagcct ggccgccaag     1200

cacatgagca acacctacct gagcggcatc gcccagtact acacccagta cagcggcacc     1260

atcaacctgc acttcatgtt caccggcagc accgacagca aggcccgcta catggtggcc     1320

tacatccccc ccggcgtgga gacccccccc gacacccccg agcgcgccgc ccactgcatc     1380

cacgccgagt gggacaccgg cctgaacagc aagttcacct tcagcatccc ctacgtgagc     1440

gccgccgact acgcctacac cgccagcgac accgccgaga ccaccaacgt gcagggctgg     1500

gtgtgcgtgt accagatcac ccacggcaag gccgagaacg acaccctggt ggtgagcgtg     1560

agcgccggca aggacttcga gctgcgcctg cccatcgacc cccgccagca gaccaccgcc     1620

accggcgaga gcgccgaccc cgtgaccacc accgtggaga actacggcgg cgagacccag     1680

gtgcagcgcc gccaccacac cgacgtgggc ttcatcatgg accgcttcgt gaagatcaac     1740

agccccaagc ccacccacgt gatcgacctg atgcagaccc accagcacgg cctggtgggc     1800

gccctgctgc gcgccgccac ctactacttc agcgacctgg agatcgtggt gcgccacgac     1860

ggcctgacct gggtgcccaa cggcgccccc gagagcgccc tgagcaacac cagcaacccc     1920

accgcctaca acaaggcccc cttcacccgc ctggccctgc cctacaccgc cccccaccgc     1980

gtgctggcca ccgtgtacaa cggcaccagc aagtacaccg tgagcggcag cagccgccgc     2040

ggcgacctgg gcagcctggc cgcccgcgtg gccaagcagc tgcccgccag cttcaactac     2100

ggcgccatca aggccgacac catccacgag ctgctggtgc gcatgaagcg cgccgagctg     2160

tactgcgtga agaagcccgt ggccctgaag gtgaaggcca agaacaccct gatcgtgacc     2220

gagagcggcg ccccccccac cgacctgcag aagatggtga tgggcaacac caagcccgtg     2280

gagctgatcc tggacggcaa gaccgtggcc atctgctgcg ccaccggcgt gttcggcacc     2340

gcctacctgg tgccccgcca cctgttcgcc gagaagtacg acaagatcat gctggacggc     2400

cgcgccatga ccgacagcga ctaccgcgtg ttcgagttcg agatcaaggt gaagggccag     2460

gacatgctga gcgacgccgc cctgatggtg ctgcaccgcg gcaaccgcgt gcgcgacatc     2520

accaagcact tccgcgacac cgcccgcatg aagaagggca cccccgtggt gggcgtgatc     2580

aacaacgccg acgtgggccg cctgatcttc agcggcgagg ccctgaccta caaggacatc     2640

gtggtgtgca tggacggcga caccatgccc ggcctgttcg cctacaaggc cgccaccaag     2700

gccggctact gcggcggcgc cgtgctggcc aaggacggcg ccgacacctt catcgtgggc     2760

acccacagcg ccggcggccg caacggcgtg ggctactgca gctgcgtgag ccgcagcatg     2820

ctgctgaaga tgaaggccca catcgacccc gagccccacc acgagggcct gatcgtggac     2880

acccgcgacg tggaggagcg cgtgcacgtg atgtga                               2916


<210>  211
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype A and consensus C3 amino acid


<220>
<221>  misc_feature
<222>  (625)..(625)
<223>  Xaa can be any naturally occurring amino acid

<400>  211

Met Leu Asn Gly Asp Trp Lys Ala Lys Val Gln Arg Lys Leu Lys Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Thr Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Ser Thr Thr Glu Asp His Val Ala 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Lys Phe Leu Phe Asp Trp Thr Thr Asp Lys Pro Phe Gly 
                165                 170                 175     


His Leu His Lys Leu Glu Leu Pro Thr Asp His His Gly Val Phe Gly 
            180                 185                 190         


His Leu Val Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu 
        195                 200                 205             


Val Ser Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Trp Lys Glu Phe Asp Thr Arg Glu Lys Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Ile Ser Pro Arg Thr Asn Met Thr Ala 
                245                 250                 255     


His Ile Thr Val Pro Tyr Leu Gly Val Asn Arg Tyr Asp Gln Tyr Lys 
            260                 265                 270         


Lys His Lys Pro Trp Thr Leu Val Val Met Val Val Ser Pro Leu Thr 
        275                 280                 285             


Val Asn Thr Ala Ala Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr 
    290                 295                 300                 


Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu Gly Ile Phe Pro 
305                 310                 315                 320 


Val Ala Cys Ala Asp Gly Tyr Gly Gly Leu Val Thr Thr Asp Pro Lys 
                325                 330                 335     


Thr Ala Asp Pro Ala Tyr Gly Lys Val Tyr Asn Pro Pro Arg Thr Asn 
            340                 345                 350         


Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala Glu Ala Cys Pro 
        355                 360                 365             


Thr Phe Leu Cys Phe Asp Asp Gly Lys Pro Tyr Val Thr Thr Arg Thr 
    370                 375                 380                 


Asp Glu Thr Arg Leu Leu Ala Lys Phe Asp Val Ser Leu Ala Ala Lys 
385                 390                 395                 400 


His Met Ser Asn Thr Tyr Leu Ser Gly Ile Ala Gln Tyr Tyr Thr Gln 
                405                 410                 415     


Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr Gly Ser Thr Asp 
            420                 425                 430         


Ser Lys Ala Arg Tyr Met Val Ala Tyr Ile Pro Pro Gly Val Glu Thr 
        435                 440                 445             


Pro Pro Asp Thr Pro Glu Arg Ala Ala His Cys Ile His Ala Glu Trp 
    450                 455                 460                 


Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Val Ser 
465                 470                 475                 480 


Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala Glu Thr Thr Asn 
                485                 490                 495     


Val Gln Gly Trp Val Cys Val Tyr Gln Ile Thr His Gly Lys Ala Glu 
            500                 505                 510         


Asn Asp Thr Leu Val Val Ser Val Ser Ala Gly Lys Asp Phe Glu Leu 
        515                 520                 525             


Arg Leu Pro Ile Asp Pro Arg Gln Gln Thr Thr Ala Thr Gly Glu Ser 
    530                 535                 540                 


Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln 
545                 550                 555                 560 


Val Gln Arg Arg His His Thr Asp Val Gly Phe Ile Met Asp Arg Phe 
                565                 570                 575     


Val Lys Ile Asn Ser Pro Lys Pro Thr His Val Ile Asp Leu Met Gln 
            580                 585                 590         


Thr His Gln His Gly Leu Val Gly Ala Leu Leu Arg Ala Ala Thr Tyr 
        595                 600                 605             


Tyr Phe Ser Asp Leu Glu Ile Val Val Arg His Asp Gly Leu Thr Trp 
    610                 615                 620                 


Xaa Pro Asn Gly Ala Pro Glu Ser Ala Leu Ser Asn Thr Ser Asn Pro 
625                 630                 635                 640 


Thr Ala Tyr Asn Lys Ala Pro Phe Thr Arg Leu Ala Leu Pro Tyr Thr 
                645                 650                 655     


Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Thr Ser Lys Tyr 
            660                 665                 670         


Thr Val Ser Gly Ser Ser Arg Arg Gly Asp Leu Gly Ser Leu Ala Ala 
        675                 680                 685             


Arg Val Ala Lys Gln Leu Pro Ala Ser Phe Asn Tyr Gly Ala Ile Lys 
    690                 695                 700                 


Ala Asp Thr Ile His Glu Leu Leu Val Arg Met Lys Arg Ala Glu Leu 
705                 710                 715                 720 


Tyr Cys Val Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Thr 
                725                 730                 735     


Leu Ile Val Thr Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met 
            740                 745                 750         


Val Met Gly Asn Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr 
        755                 760                 765             


Val Ala Ile Cys Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val 
    770                 775                 780                 


Pro Arg His Leu Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly 
785                 790                 795                 800 


Arg Ala Met Thr Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys 
                805                 810                 815     


Val Lys Gly Gln Asp Met Leu Ser Asp Ala Ala Leu Met Val Leu His 
            820                 825                 830         


Arg Gly Asn Arg Val Arg Asp Ile Thr Lys His Phe Arg Asp Thr Ala 
        835                 840                 845             


Arg Met Lys Lys Gly Thr Pro Val Val Gly Val Ile Asn Asn Ala Asp 
    850                 855                 860                 


Val Gly Arg Leu Ile Phe Ser Gly Glu Ala Leu Thr Tyr Lys Asp Ile 
865                 870                 875                 880 


Val Val Cys Met Asp Gly Asp Thr Met Pro Gly Leu Phe Ala Tyr Lys 
                885                 890                 895     


Ala Ala Thr Lys Ala Gly Tyr Cys Gly Gly Ala Val Leu Ala Lys Asp 
            900                 905                 910         


Gly Ala Asp Thr Phe Ile Val Gly Thr His Ser Ala Gly Gly Arg Asn 
        915                 920                 925             


Gly Val Gly Tyr Cys Ser Cys Val Ser Arg Ser Met Leu Leu Lys Met 
    930                 935                 940                 


Lys Ala His Ile Asp Pro Glu Pro His His Glu Gly Leu Ile Val Asp 
945                 950                 955                 960 


Thr Arg Asp Val Glu Glu Arg Val His Val Met 
                965                 970     


<210>  212
<211>  2916
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype Asia 1 and consensus C3 nucleic acid

<400>  212
atgctgaacg gcgagtggaa ggccaaggtg cagaagcgcc tgaagggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaacaacac ccagaacaac      240

gactggttca gccgcctggc cagcagcgcc ttcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgcaacggc      360

cacaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacgc cgtggccgag      420

gacgccgtga gcggccccaa caccagcggc ctggagaccc gcgtgcagca ggccgagcgc      480

ttcttcaaga agcacctgtt cgactggacc cccaacctgg ccttcggcca ctgccactac      540

ctggagctgc ccaccgagca caagggcgtg tacggcagcc tgatggacag ctacgcctac      600

atgcgcaacg gctgggacat cgaggtgacc gccgtgggca accagttcaa cggcggctgc      660

ctgctggtgg ccctggtgcc cgagctgaag agcctggaca cccgccagaa gtaccagctg      720

accctgttcc cccaccagtt catcaacccc cgcaccaaca tgaccgccca catcaacgtg      780

cccttcgtgg gcgtgaaccg ctacgaccag tacgccctgc acaagccctg gaccctggtg      840

gtgatggtgg tggcccccct gaccgtgaag accggcggca gcgagcagat caaggtgtac      900

atgaacgccg cccccaccta cgtgcacgtg gccggcgagc tgcccagcaa ggagggcatc      960

gtgcccgtgg cctgcgccga cggctacggc aacatggtga ccaccgaccc caagaccgcc     1020

gaccccgtgt acggcaaggt gttcaacccc ccccgcacca acctgcccgg ccgcttcacc     1080

aacttcctgg acgtggccga ggcctgcccc accttcctgc gcttcggcga ggtgcccttc     1140

gtgaagaccg tgaacagcgg cgaccgcctg ctggccaagt tcgacgtgag cctggccgcc     1200

ggccacatga gcaacaccta cctggccggc ctggcccagt actacaccca gtacagcggc     1260

accatgaacg tgcacttcat gttcaccggc cccaccgacg ccaaggcccg ctacatggtg     1320

gcctacatcc cccccggcat gacccccccc accgaccccg agcgcgccgc ccactgcatc     1380

cacagcgagt gggacaccgg cctgaacagc aagttcacct tcagcatccc ctacctgagc     1440

gccgccgact acgcctacac cgccagcgac accgccgaga ccaccagcgt gcagggctgg     1500

gtgtgcatct accagatcac ccacggcaag gccgagggcg acgccctggt ggtgagcgtg     1560

agcgccggca aggacttcga gttccgcctg cccgtggacg cccgccgcca gaccaccacc     1620

accggcgaga gcgccgaccc cgtgaccacc accgtggaga actacggcgg cgagacccag     1680

accgcccgcc gcctgcacac cgacgtggcc ttcgtgctgg accgcttcgt gaagctgacc     1740

gcccccaaga acacccagac cctggacctg atgcagatcc ccagccacac cctggtgggc     1800

gccctgctgc gcagcgccac ctactacttc agcgacctgg aggtggccct ggtgcacacc     1860

ggccccgtga cctgggtgcc caacggcagc cccaaggacg ccctggacaa ccagaccaac     1920

cccaccgcct accagaagca gcccatcacc cgcctggccc tgccctacac cgccccccac     1980

cgcgtgctgg ccaccgtgta caacggcaag accacctacg gcgagacccc cagccgccgc     2040

ggcgacatgg ccgccctggc ccagcgcctg agcgagcgcc tgcccaccag cttcaactac     2100

ggcgccgtga aggccgagac catcaccgag ctgctgatcc gcatgaagcg cgccgagacc     2160

tactgcgtga agaagcccgt ggccctgaag gtgaaggcca agaacaccct gatcgtgacc     2220

gagagcggcg ccccccccac cgacctgcag aagatggtga tgggcaacac caagcccgtg     2280

gagctgatcc tggacggcaa gaccgtggcc atctgctgcg ccaccggcgt gttcggcacc     2340

gcctacctgg tgccccgcca cctgttcgcc gagaagtacg acaagatcat gctggacggc     2400

cgcgccatga ccgacagcga ctaccgcgtg ttcgagttcg agatcaaggt gaagggccag     2460

gacatgctga gcgacgccgc cctgatggtg ctgcaccgcg gcaaccgcgt gcgcgacatc     2520

accaagcact tccgcgacac cgcccgcatg aagaagggca cccccgtggt gggcgtgatc     2580

aacaacgccg acgtgggccg cctgatcttc agcggcgagg ccctgaccta caaggacatc     2640

gtggtgtgca tggacggcga caccatgccc ggcctgttcg cctacaaggc cgccaccaag     2700

gccggctact gcggcggcgc cgtgctggcc aaggacggcg ccgacacctt catcgtgggc     2760

acccacagcg ccggcggccg caacggcgtg ggctactgca gctgcgtgag ccgcagcatg     2820

ctgctgaaga tgaaggccca catcgacccc gagccccacc acgagggcct gatcgtggac     2880

acccgcgacg tggaggagcg cgtgcacgtg atgtga                               2916


<210>  213
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype Asia 1 and consensus C3 amino acid

<400>  213

Met Leu Asn Gly Glu Trp Lys Ala Lys Val Gln Lys Arg Leu Lys Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Arg Leu Ala Ser Ser Ala Phe Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Ala Val Ala Glu Asp Ala Val Ser 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Gln Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Lys His Leu Phe Asp Trp Thr Pro Asn Leu Ala Phe Gly 
                165                 170                 175     


His Cys His Tyr Leu Glu Leu Pro Thr Glu His Lys Gly Val Tyr Gly 
            180                 185                 190         


Ser Leu Met Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Ile Glu 
        195                 200                 205             


Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Leu Val Pro Glu Leu Lys Ser Leu Asp Thr Arg Gln Lys Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala 
                245                 250                 255     


His Ile Asn Val Pro Phe Val Gly Val Asn Arg Tyr Asp Gln Tyr Ala 
            260                 265                 270         


Leu His Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr 
        275                 280                 285             


Val Lys Thr Gly Gly Ser Glu Gln Ile Lys Val Tyr Met Asn Ala Ala 
    290                 295                 300                 


Pro Thr Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu Gly Ile 
305                 310                 315                 320 


Val Pro Val Ala Cys Ala Asp Gly Tyr Gly Asn Met Val Thr Thr Asp 
                325                 330                 335     


Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Phe Asn Pro Pro Arg 
            340                 345                 350         


Thr Asn Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val Ala Glu Ala 
        355                 360                 365             


Cys Pro Thr Phe Leu Arg Phe Gly Glu Val Pro Phe Val Lys Thr Val 
    370                 375                 380                 


Asn Ser Gly Asp Arg Leu Leu Ala Lys Phe Asp Val Ser Leu Ala Ala 
385                 390                 395                 400 


Gly His Met Ser Asn Thr Tyr Leu Ala Gly Leu Ala Gln Tyr Tyr Thr 
                405                 410                 415     


Gln Tyr Ser Gly Thr Met Asn Val His Phe Met Phe Thr Gly Pro Thr 
            420                 425                 430         


Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Ile Pro Pro Gly Met Thr 
        435                 440                 445             


Pro Pro Thr Asp Pro Glu Arg Ala Ala His Cys Ile His Ser Glu Trp 
    450                 455                 460                 


Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Leu Ser 
465                 470                 475                 480 


Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala Glu Thr Thr Ser 
                485                 490                 495     


Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His Gly Lys Ala Glu 
            500                 505                 510         


Gly Asp Ala Leu Val Val Ser Val Ser Ala Gly Lys Asp Phe Glu Phe 
        515                 520                 525             


Arg Leu Pro Val Asp Ala Arg Arg Gln Thr Thr Thr Thr Gly Glu Ser 
    530                 535                 540                 


Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln 
545                 550                 555                 560 


Thr Ala Arg Arg Leu His Thr Asp Val Ala Phe Val Leu Asp Arg Phe 
                565                 570                 575     


Val Lys Leu Thr Ala Pro Lys Asn Thr Gln Thr Leu Asp Leu Met Gln 
            580                 585                 590         


Ile Pro Ser His Thr Leu Val Gly Ala Leu Leu Arg Ser Ala Thr Tyr 
        595                 600                 605             


Tyr Phe Ser Asp Leu Glu Val Ala Leu Val His Thr Gly Pro Val Thr 
    610                 615                 620                 


Trp Val Pro Asn Gly Ser Pro Lys Asp Ala Leu Asp Asn Gln Thr Asn 
625                 630                 635                 640 


Pro Thr Ala Tyr Gln Lys Gln Pro Ile Thr Arg Leu Ala Leu Pro Tyr 
                645                 650                 655     


Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Lys Thr Thr 
            660                 665                 670         


Tyr Gly Glu Thr Pro Ser Arg Arg Gly Asp Met Ala Ala Leu Ala Gln 
        675                 680                 685             


Arg Leu Ser Glu Arg Leu Pro Thr Ser Phe Asn Tyr Gly Ala Val Lys 
    690                 695                 700                 


Ala Glu Thr Ile Thr Glu Leu Leu Ile Arg Met Lys Arg Ala Glu Thr 
705                 710                 715                 720 


Tyr Cys Val Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Thr 
                725                 730                 735     


Leu Ile Val Thr Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met 
            740                 745                 750         


Val Met Gly Asn Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr 
        755                 760                 765             


Val Ala Ile Cys Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val 
    770                 775                 780                 


Pro Arg His Leu Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly 
785                 790                 795                 800 


Arg Ala Met Thr Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys 
                805                 810                 815     


Val Lys Gly Gln Asp Met Leu Ser Asp Ala Ala Leu Met Val Leu His 
            820                 825                 830         


Arg Gly Asn Arg Val Arg Asp Ile Thr Lys His Phe Arg Asp Thr Ala 
        835                 840                 845             


Arg Met Lys Lys Gly Thr Pro Val Val Gly Val Ile Asn Asn Ala Asp 
    850                 855                 860                 


Val Gly Arg Leu Ile Phe Ser Gly Glu Ala Leu Thr Tyr Lys Asp Ile 
865                 870                 875                 880 


Val Val Cys Met Asp Gly Asp Thr Met Pro Gly Leu Phe Ala Tyr Lys 
                885                 890                 895     


Ala Ala Thr Lys Ala Gly Tyr Cys Gly Gly Ala Val Leu Ala Lys Asp 
            900                 905                 910         


Gly Ala Asp Thr Phe Ile Val Gly Thr His Ser Ala Gly Gly Arg Asn 
        915                 920                 925             


Gly Val Gly Tyr Cys Ser Cys Val Ser Arg Ser Met Leu Leu Lys Met 
    930                 935                 940                 


Lys Ala His Ile Asp Pro Glu Pro His His Glu Gly Leu Ile Val Asp 
945                 950                 955                 960 


Thr Arg Asp Val Glu Glu Arg Val His Val Met 
                965                 970     


<210>  214
<211>  2913
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype C and consensus C3 nucleic acid

<400>  214
atgctgaacg agggctggaa ggccagcgtg cagcgcaagc tgaagggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaccaacac ccagaacaac      240

gactggttca gcaagctggc cagcagcgcc ttcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgcaacggc      360

cacaccacca gcaccaccca gagcagcgtg ggcgtgacct tcggctacgc caccgccgag      420

gacagcacca gcggccccaa caccagcggc ctggagaccc gcgtgcacca ggccgagcgc      480

ttcttcaaga tggccctgtt cgactgggtg cccagccaga acttcggcca catgcacaag      540

gtggtgctgc cccacgagcc caagggcgtg tacggcggcc tggtgaagag ctacgcctac      600

atgcgcaacg gctgggacgt ggaggtgacc gccgtgggca accagttcaa cggcggctgc      660

ctgctggtgg ccctggtgcc cgagatgggc gacatcagcg accgcgagaa gtaccagctg      720

accctgtacc cccaccagtt catcaacccc cgcaccaaca tgaccgccca catcaccgtg      780

ccctacgtgg gcgtgaaccg ctacgaccag tacaagcagc accgcccctg gaccctggtg      840

gtgatggtgg tggcccccct gaccaccaac accgccggcg cccagcagat caaggtgtac      900

gccaacatcg cccccaccaa cgtgcacgtg gccggcgagc tgcccagcaa ggagggcatc      960

ttccccgtgg cctgcagcga cggctacggc aacatggtga ccaccgaccc caagaccgcc     1020

gaccccgtgt acggcaaggt gtacaacccc ccccgcaccg ccctgcccgg ccgcttcacc     1080

aactacctgg acgtggccga ggcctgcccc accttcctga tgttcgagaa cgtgccctac     1140

gtgagcaccc gcaccgacgg ccagcgcctg ctggccaagt tcgacgtgag cctggccgcc     1200

aagcacatga gcaacaccta cctggccggc ctggcccagt actacaccca gtacaccggc     1260

accatcaacc tgcacttcat gttcaccggc cccaccgacg ccaaggcccg ctacatggtg     1320

gcctacgtgc cccccggcat ggacgccccc gacaaccccg aggaggccgc ccactgcatc     1380

cacgccgagt gggacaccgg cctgaacagc aagttcacct tcagcatccc ctacatcagc     1440

gccgccgact acgcctacac cgccagccac aaggccgaga ccacctgcgt gcagggctgg     1500

gtgtgcgtgt accagatcac ccacggcaag gccgacgccg acgccctggt ggtgagcgcc     1560

agcgccggca aggacttcga gctgcgcctg cccgtggacg cccgcaagca gaccaccacc     1620

accggcgaga gcgccgaccc cgtgaccacc accgtggaga actacggcgg cgagacccag     1680

gtgcagcgcc gccaccacac cgacgtggcc ttcgtgctgg accgcttcgt ggaggtgacc     1740

gtgagcggcc gcaaccagca caccctggac gtgatgcagg cccacaagga caacatcgtg     1800

ggcgccctgc tgcgcgccgc cacctactac ttcagcgacc tggagatcgc cgtgacccac     1860

accggcaagc tgacctgggt gcccaacggc gcccccgtga gcgccctgaa caacaccacc     1920

aaccccaccg cctaccacaa gggccccgtg acccgcctgg ccctgcccta caccgccccc     1980

caccgcgtgc tggccaccgc ctacaccggc accaccacct acaccgccag cgcccgcggc     2040

gacctggccc acctgaccac cacccacgcc cgccacctgc ccaccagctt caacttcggc     2100

gccgtgaagg ccgagaccat caccgagctg ctggtgcgca tgaagcgcgc cgagctgtac     2160

tgcgtgaaga agcccgtggc cctgaaggtg aaggccaaga acaccctgat cgtgaccgag     2220

agcggcgccc cccccaccga cctgcagaag atggtgatgg gcaacaccaa gcccgtggag     2280

ctgatcctgg acggcaagac cgtggccatc tgctgcgcca ccggcgtgtt cggcaccgcc     2340

tacctggtgc cccgccacct gttcgccgag aagtacgaca agatcatgct ggacggccgc     2400

gccatgaccg acagcgacta ccgcgtgttc gagttcgaga tcaaggtgaa gggccaggac     2460

atgctgagcg acgccgccct gatggtgctg caccgcggca accgcgtgcg cgacatcacc     2520

aagcacttcc gcgacaccgc ccgcatgaag aagggcaccc ccgtggtggg cgtgatcaac     2580

aacgccgacg tgggccgcct gatcttcagc ggcgaggccc tgacctacaa ggacatcgtg     2640

gtgtgcatgg acggcgacac catgcccggc ctgttcgcct acaaggccgc caccaaggcc     2700

ggctactgcg gcggcgccgt gctggccaag gacggcgccg acaccttcat cgtgggcacc     2760

cacagcgccg gcggccgcaa cggcgtgggc tactgcagct gcgtgagccg cagcatgctg     2820

ctgaagatga aggcccacat cgaccccgag ccccaccacg agggcctgat cgtggacacc     2880

cgcgacgtgg aggagcgcgt gcacgtgatg tga                                  2913


<210>  215
<211>  970
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype C and consensus C3 amino acid

<400>  215

Met Leu Asn Glu Gly Trp Lys Ala Ser Val Gln Arg Lys Leu Lys Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Phe Gly Tyr Ala Thr Ala Glu Asp Ser Thr Ser 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val His Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Met Ala Leu Phe Asp Trp Val Pro Ser Gln Asn Phe Gly 
                165                 170                 175     


His Met His Lys Val Val Leu Pro His Glu Pro Lys Gly Val Tyr Gly 
            180                 185                 190         


Gly Leu Val Lys Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu 
        195                 200                 205             


Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Leu Val Pro Glu Met Gly Asp Ile Ser Asp Arg Glu Lys Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Tyr Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala 
                245                 250                 255     


His Ile Thr Val Pro Tyr Val Gly Val Asn Arg Tyr Asp Gln Tyr Lys 
            260                 265                 270         


Gln His Arg Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr 
        275                 280                 285             


Thr Asn Thr Ala Gly Ala Gln Gln Ile Lys Val Tyr Ala Asn Ile Ala 
    290                 295                 300                 


Pro Thr Asn Val His Val Ala Gly Glu Leu Pro Ser Lys Glu Gly Ile 
305                 310                 315                 320 


Phe Pro Val Ala Cys Ser Asp Gly Tyr Gly Asn Met Val Thr Thr Asp 
                325                 330                 335     


Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Tyr Asn Pro Pro Arg 
            340                 345                 350         


Thr Ala Leu Pro Gly Arg Phe Thr Asn Tyr Leu Asp Val Ala Glu Ala 
        355                 360                 365             


Cys Pro Thr Phe Leu Met Phe Glu Asn Val Pro Tyr Val Ser Thr Arg 
    370                 375                 380                 


Thr Asp Gly Gln Arg Leu Leu Ala Lys Phe Asp Val Ser Leu Ala Ala 
385                 390                 395                 400 


Lys His Met Ser Asn Thr Tyr Leu Ala Gly Leu Ala Gln Tyr Tyr Thr 
                405                 410                 415     


Gln Tyr Thr Gly Thr Ile Asn Leu His Phe Met Phe Thr Gly Pro Thr 
            420                 425                 430         


Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Val Pro Pro Gly Met Asp 
        435                 440                 445             


Ala Pro Asp Asn Pro Glu Glu Ala Ala His Cys Ile His Ala Glu Trp 
    450                 455                 460                 


Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Ile Ser 
465                 470                 475                 480 


Ala Ala Asp Tyr Ala Tyr Thr Ala Ser His Lys Ala Glu Thr Thr Cys 
                485                 490                 495     


Val Gln Gly Trp Val Cys Val Tyr Gln Ile Thr His Gly Lys Ala Asp 
            500                 505                 510         


Ala Asp Ala Leu Val Val Ser Ala Ser Ala Gly Lys Asp Phe Glu Leu 
        515                 520                 525             


Arg Leu Pro Val Asp Ala Arg Lys Gln Thr Thr Thr Thr Gly Glu Ser 
    530                 535                 540                 


Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln 
545                 550                 555                 560 


Val Gln Arg Arg His His Thr Asp Val Ala Phe Val Leu Asp Arg Phe 
                565                 570                 575     


Val Glu Val Thr Val Ser Gly Arg Asn Gln His Thr Leu Asp Val Met 
            580                 585                 590         


Gln Ala His Lys Asp Asn Ile Val Gly Ala Leu Leu Arg Ala Ala Thr 
        595                 600                 605             


Tyr Tyr Phe Ser Asp Leu Glu Ile Ala Val Thr His Thr Gly Lys Leu 
    610                 615                 620                 


Thr Trp Val Pro Asn Gly Ala Pro Val Ser Ala Leu Asn Asn Thr Thr 
625                 630                 635                 640 


Asn Pro Thr Ala Tyr His Lys Gly Pro Val Thr Arg Leu Ala Leu Pro 
                645                 650                 655     


Tyr Thr Ala Pro His Arg Val Leu Ala Thr Ala Tyr Thr Gly Thr Thr 
            660                 665                 670         


Thr Tyr Thr Ala Ser Ala Arg Gly Asp Leu Ala His Leu Thr Thr Thr 
        675                 680                 685             


His Ala Arg His Leu Pro Thr Ser Phe Asn Phe Gly Ala Val Lys Ala 
    690                 695                 700                 


Glu Thr Ile Thr Glu Leu Leu Val Arg Met Lys Arg Ala Glu Leu Tyr 
705                 710                 715                 720 


Cys Val Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Thr Leu 
                725                 730                 735     


Ile Val Thr Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met Val 
            740                 745                 750         


Met Gly Asn Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr Val 
        755                 760                 765             


Ala Ile Cys Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val Pro 
    770                 775                 780                 


Arg His Leu Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly Arg 
785                 790                 795                 800 


Ala Met Thr Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys Val 
                805                 810                 815     


Lys Gly Gln Asp Met Leu Ser Asp Ala Ala Leu Met Val Leu His Arg 
            820                 825                 830         


Gly Asn Arg Val Arg Asp Ile Thr Lys His Phe Arg Asp Thr Ala Arg 
        835                 840                 845             


Met Lys Lys Gly Thr Pro Val Val Gly Val Ile Asn Asn Ala Asp Val 
    850                 855                 860                 


Gly Arg Leu Ile Phe Ser Gly Glu Ala Leu Thr Tyr Lys Asp Ile Val 
865                 870                 875                 880 


Val Cys Met Asp Gly Asp Thr Met Pro Gly Leu Phe Ala Tyr Lys Ala 
                885                 890                 895     


Ala Thr Lys Ala Gly Tyr Cys Gly Gly Ala Val Leu Ala Lys Asp Gly 
            900                 905                 910         


Ala Asp Thr Phe Ile Val Gly Thr His Ser Ala Gly Gly Arg Asn Gly 
        915                 920                 925             


Val Gly Tyr Cys Ser Cys Val Ser Arg Ser Met Leu Leu Lys Met Lys 
    930                 935                 940                 


Ala His Ile Asp Pro Glu Pro His His Glu Gly Leu Ile Val Asp Thr 
945                 950                 955                 960 


Arg Asp Val Glu Glu Arg Val His Val Met 
                965                 970 


<210>  216
<211>  2925
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype O and consensus C3 nucleic acid

<400>  216
atgctgaacg gcgagtggaa ggccaaggtg cagaagcgcc tgcgcggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaccaacac ccagaacaac      240

gactggttca gcaagctggc cagcagcgcc ttcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgcaacggc      360

cacaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacgc caccgccgag      420

gacttcgtga gcggccccaa caccagcggc ctggagaccc gcgtggtgca ggccgagcgc      480

ttcttcaaga cccacctgtt cgactgggtg accagcgacc ccttcggccg ctgctacctg      540

ctggagctgc ccaccgacca caagggcgtg tacggcagcc tgaccgacag ctacgcctac      600

atgcgcaacg gctgggacgt ggaggtgacc gccgtgggca accagttcaa cggcggctgc      660

ctgctggtgg ccatggtgcc cgagctgtgc agcatcgaca agcgcgagct gtaccagctg      720

accctgttcc cccaccagtt catcaacccc cgcaccaaca tgaccgccca catcaccgtg      780

cccttcgtgg gcgtgaaccg ctacgaccag tacaaggtgc acaagccctg gaccctggtg      840

gtgatggtgg tggcccccct gaccgtgaac accgagggcg ccccccagat caaggtgtac      900

gccaacatcg cccccaccaa cgtgcacgtg gccggcgagt tccccagcaa ggagggcatc      960

ttccccgtgg cctgcagcga cggctacggc ggcctggtga ccaccgaccc caagaccgcc     1020

gaccccgcct acggcaaggt gttcaacccc ccccgcaaca tgctgcccgg ccgcttcacc     1080

aacttcctgg acgtggccga ggcctgcccc accttcctgc acttcgaggg cggcgtgccc     1140

tacgtgacca ccaagaccga cagcgaccgc gtgctggccc agttcgacct gagcctggcc     1200

gccaagcaca tgagcaacac cttcctggcc ggcctggccc agtactacac ccagtacagc     1260

ggcaccatca acctgcactt catgttcacc ggccccaccg acgccaaggc ccgctacatg     1320

atcgcctacg ccccccccgg catggagccc cccaagaccc ccgaggccgc cgcccactgc     1380

atccacgccg agtgggacac cggcctgaac agcaagttca ccttcagcat cccctacctg     1440

agcgccgccg actacgccta caccgccagc gacgccgccg agaccaccaa cgtgcagggc     1500

tgggtgtgcc tgttccagat cacccacggc aaggccgacg gcgacgccct ggtggtgctg     1560

gccagcgccg gcaaggactt cgagctgcgc ctgcccgtgg acgcccgcac ccagaccacc     1620

agcgccggcg agagcgccga ccccgtgacc gccaccgtgg agaactacgg cggcgagacc     1680

caggtgcagc gccgccagca caccgacgtg agcttcatcc tggaccgctt cgtgaaggtg     1740

acccccaagg accagatcaa cgtgctggac ctgatgcaga cccccgccca caccctggtg     1800

ggcgccctgc tgcgcaccgc cacctactac ttcgccgacc tggaggtggc cgtgaagcac     1860

gagggcaacc tgacctgggt gcccaacggc gcccccgaga ccgccctgga caacaccacc     1920

aaccccaccg cctaccacaa ggcccccctg acccgcctgg ccctgcccta caccgccccc     1980

caccgcgtgc tggccaccgt gtacaacggc aactgcaagt acggcgagag ccccgtgacc     2040

aacgtgcgcg gcgacctgca ggtgctggcc cagaaggccg cccgcaccct gcccaccagc     2100

ttcaactacg gcgccatcaa ggccacccgc gtgaccgagc tgctgtaccg catgaagcgc     2160

gccgagacct actgcgtgaa gaagcccgtg gccctgaagg tgaaggccaa gaacaccctg     2220

atcgtgaccg agagcggcgc cccccccacc gacctgcaga agatggtgat gggcaacacc     2280

aagcccgtgg agctgatcct ggacggcaag accgtggcca tctgctgcgc caccggcgtg     2340

ttcggcaccg cctacctggt gccccgccac ctgttcgccg agaagtacga caagatcatg     2400

ctggacggcc gcgccatgac cgacagcgac taccgcgtgt tcgagttcga gatcaaggtg     2460

aagggccagg acatgctgag cgacgccgcc ctgatggtgc tgcaccgcgg caaccgcgtg     2520

cgcgacatca ccaagcactt ccgcgacacc gcccgcatga agaagggcac ccccgtggtg     2580

ggcgtgatca acaacgccga cgtgggccgc ctgatcttca gcggcgaggc cctgacctac     2640

aaggacatcg tggtgtgcat ggacggcgac accatgcccg gcctgttcgc ctacaaggcc     2700

gccaccaagg ccggctactg cggcggcgcc gtgctggcca aggacggcgc cgacaccttc     2760

atcgtgggca cccacagcgc cggcggccgc aacggcgtgg gctactgcag ctgcgtgagc     2820

cgcagcatgc tgctgaagat gaaggcccac atcgaccccg agccccacca cgagggcctg     2880

atcgtggaca cccgcgacgt ggaggagcgc gtgcacgtga tgtga                     2925


<210>  217
<211>  974
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype O and consensus C3 amino acid

<400>  217

Met Leu Asn Gly Glu Trp Lys Ala Lys Val Gln Lys Arg Leu Arg Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Ala Thr Ala Glu Asp Phe Val Ser 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Thr His Leu Phe Asp Trp Val Thr Ser Asp Pro Phe Gly 
                165                 170                 175     


Arg Cys Tyr Leu Leu Glu Leu Pro Thr Asp His Lys Gly Val Tyr Gly 
            180                 185                 190         


Ser Leu Thr Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu 
        195                 200                 205             


Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Leu Cys Ser Ile Asp Lys Arg Glu Leu Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala 
                245                 250                 255     


His Ile Thr Val Pro Phe Val Gly Val Asn Arg Tyr Asp Gln Tyr Lys 
            260                 265                 270         


Val His Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr 
        275                 280                 285             


Val Asn Thr Glu Gly Ala Pro Gln Ile Lys Val Tyr Ala Asn Ile Ala 
    290                 295                 300                 


Pro Thr Asn Val His Val Ala Gly Glu Phe Pro Ser Lys Glu Gly Ile 
305                 310                 315                 320 


Phe Pro Val Ala Cys Ser Asp Gly Tyr Gly Gly Leu Val Thr Thr Asp 
                325                 330                 335     


Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val Phe Asn Pro Pro Arg 
            340                 345                 350         


Asn Met Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val Ala Glu Ala 
        355                 360                 365             


Cys Pro Thr Phe Leu His Phe Glu Gly Gly Val Pro Tyr Val Thr Thr 
    370                 375                 380                 


Lys Thr Asp Ser Asp Arg Val Leu Ala Gln Phe Asp Leu Ser Leu Ala 
385                 390                 395                 400 


Ala Lys His Met Ser Asn Thr Phe Leu Ala Gly Leu Ala Gln Tyr Tyr 
                405                 410                 415     


Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr Gly Pro 
            420                 425                 430         


Thr Asp Ala Lys Ala Arg Tyr Met Ile Ala Tyr Ala Pro Pro Gly Met 
        435                 440                 445             


Glu Pro Pro Lys Thr Pro Glu Ala Ala Ala His Cys Ile His Ala Glu 
    450                 455                 460                 


Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Leu 
465                 470                 475                 480 


Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Ala Ala Glu Thr Thr 
                485                 490                 495     


Asn Val Gln Gly Trp Val Cys Leu Phe Gln Ile Thr His Gly Lys Ala 
            500                 505                 510         


Asp Gly Asp Ala Leu Val Val Leu Ala Ser Ala Gly Lys Asp Phe Glu 
        515                 520                 525             


Leu Arg Leu Pro Val Asp Ala Arg Thr Gln Thr Thr Ser Ala Gly Glu 
    530                 535                 540                 


Ser Ala Asp Pro Val Thr Ala Thr Val Glu Asn Tyr Gly Gly Glu Thr 
545                 550                 555                 560 


Gln Val Gln Arg Arg Gln His Thr Asp Val Ser Phe Ile Leu Asp Arg 
                565                 570                 575     


Phe Val Lys Val Thr Pro Lys Asp Gln Ile Asn Val Leu Asp Leu Met 
            580                 585                 590         


Gln Thr Pro Ala His Thr Leu Val Gly Ala Leu Leu Arg Thr Ala Thr 
        595                 600                 605             


Tyr Tyr Phe Ala Asp Leu Glu Val Ala Val Lys His Glu Gly Asn Leu 
    610                 615                 620                 


Thr Trp Val Pro Asn Gly Ala Pro Glu Thr Ala Leu Asp Asn Thr Thr 
625                 630                 635                 640 


Asn Pro Thr Ala Tyr His Lys Ala Pro Leu Thr Arg Leu Ala Leu Pro 
                645                 650                 655     


Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Asn Cys 
            660                 665                 670         


Lys Tyr Gly Glu Ser Pro Val Thr Asn Val Arg Gly Asp Leu Gln Val 
        675                 680                 685             


Leu Ala Gln Lys Ala Ala Arg Thr Leu Pro Thr Ser Phe Asn Tyr Gly 
    690                 695                 700                 


Ala Ile Lys Ala Thr Arg Val Thr Glu Leu Leu Tyr Arg Met Lys Arg 
705                 710                 715                 720 


Ala Glu Thr Tyr Cys Val Lys Lys Pro Val Ala Leu Lys Val Lys Ala 
                725                 730                 735     


Lys Asn Thr Leu Ile Val Thr Glu Ser Gly Ala Pro Pro Thr Asp Leu 
            740                 745                 750         


Gln Lys Met Val Met Gly Asn Thr Lys Pro Val Glu Leu Ile Leu Asp 
        755                 760                 765             


Gly Lys Thr Val Ala Ile Cys Cys Ala Thr Gly Val Phe Gly Thr Ala 
    770                 775                 780                 


Tyr Leu Val Pro Arg His Leu Phe Ala Glu Lys Tyr Asp Lys Ile Met 
785                 790                 795                 800 


Leu Asp Gly Arg Ala Met Thr Asp Ser Asp Tyr Arg Val Phe Glu Phe 
                805                 810                 815     


Glu Ile Lys Val Lys Gly Gln Asp Met Leu Ser Asp Ala Ala Leu Met 
            820                 825                 830         


Val Leu His Arg Gly Asn Arg Val Arg Asp Ile Thr Lys His Phe Arg 
        835                 840                 845             


Asp Thr Ala Arg Met Lys Lys Gly Thr Pro Val Val Gly Val Ile Asn 
    850                 855                 860                 


Asn Ala Asp Val Gly Arg Leu Ile Phe Ser Gly Glu Ala Leu Thr Tyr 
865                 870                 875                 880 


Lys Asp Ile Val Val Cys Met Asp Gly Asp Thr Met Pro Gly Leu Phe 
                885                 890                 895     


Ala Tyr Lys Ala Ala Thr Lys Ala Gly Tyr Cys Gly Gly Ala Val Leu 
            900                 905                 910         


Ala Lys Asp Gly Ala Asp Thr Phe Ile Val Gly Thr His Ser Ala Gly 
        915                 920                 925             


Gly Arg Asn Gly Val Gly Tyr Cys Ser Cys Val Ser Arg Ser Met Leu 
    930                 935                 940                 


Leu Lys Met Lys Ala His Ile Asp Pro Glu Pro His His Glu Gly Leu 
945                 950                 955                 960 


Ile Val Asp Thr Arg Asp Val Glu Glu Arg Val His Val Met 
                965                 970                 


<210>  218
<211>  2952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT1 and consensus C3 nucleis acid

<400>  218
atgctggacg tggactggca ggaccgcgcc ggcctgttcc tgcgcggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaacaacac ccagaacaac      240

gactggttca gcaagctggc ccagagcgcc ttcagcggcc tggtgggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcatgaccac cagccacggc      360

accaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacgc cctggccgac      420

aagttcctgc ccggccccaa caccaacggc ctggagaccc gcgtggagca ggccgagcgc      480

ttcttcaagc acaagctgtt cgactggacc accgaccagc agttcggcac cacccacgtg      540

ctggagctgc ccaccgacca caagggcatc tacggccagc tggtggacag ccacgcctac      600

atccgcaacg gctgggacgt gcaggtgagc gccaccgcca cccagttcaa cggcggctgc      660

ctgctggtgg ccatggtgcc cgagctgtgc aagctggacg accgcgagaa gtaccagctg      720

accctgttcc cccaccagtt cctgaacccc cgcaccaaca ccaccgccca catccaggtg      780

ccctacctgg gcgtggaccg ccacgaccag ggcacccgcc acaaggcctg gaccctggtg      840

gtgatggtgg tggcccccta caccaacgac cagaccatcg gcagcaccaa ggccgaggtg      900

tacgtgaaca tcgcccccac caacgtgtac gtggccggcg agaagcccgc caagcagggc      960

atcctgcccg tggccgtgag cgacggctac ggcggcttcc agaacaccga ccccaagacc     1020

agcgacccca tctacggcca cgtgtacaac cccgcccgca ccctgtaccc cggccgcttc     1080

accaacctgc tggacgtggc cgaggcctgc cccaccctgc tggacttcaa cggcgtgccc     1140

tacgtgcaga cccagaacaa cagcggcagc aaggtgctgg cccgcttcga cctggccttc     1200

ggccacaaga acatgaagaa cacctacatg agcggcctgg cccagtactt cgcccagtac     1260

agcggcaccc tgaacctgca cttcatgtac accggcccca ccaacaacaa ggccaagtac     1320

atggtggcct acatcccccc cggcacccac cccctgcccg agacccccga gatggccagc     1380

cactgctacc acgccgagtg ggacaccggc ctgaacagca ccttcacctt caccgtgccc     1440

tacatcagcg ccgccgacta cgcctacacc tacgccgacg agcccgagca ggccagcgtg     1500

cagggctggg tgggcgtgta ccagatcacc gacacccacg agaaggacgg cgccgtgatc     1560

gtgaccgtga gcgccggccc cgacttcgag ttccgcatgc ccatcagccc cagccgccag     1620

accaccagcg ccggcgaggg cgccgacccc gtgaccaccg acgtgagcga gcacggcggc     1680

gacagccgca ccgcccgccg cgcccacacc gacgtggcct tcctgctgga ccgcttcacc     1740

ctggtgggca agacccagga caacaagctg gtgctggacc tgctgaccac caaggagaag     1800

agcctggtgg gcgccctgct gcgcgccgcc acctactact tcagcgacct ggaggtggcc     1860

tgcgtgggca ccaacaagtg ggtgggctgg acccccaacg gcagccccgt gaagctgagc     1920

gaggtgggcg acaaccccgt ggtgttcagc cacaacggca ccacccgctt cgccctgccc     1980

tacaccgccc cccaccgcgt gctggccacc gtgtacaacg gcgactgcaa gtacaagccc     2040

accggcaccc ccccccgcga gaacatccgc ggcgacctgg ccaccctggc cgcccgcatc     2100

gccagcgaga cccacatccc caccaccttc aactacggca tgatctacac cgaggccgag     2160

gtggacgtgt acctgcgcat gaagcgcgcc gagctgtact gcgtgaagaa gcccgtggcc     2220

ctgaaggtga aggccaagaa caccctgatc gtgaccgaga gcggcgcccc ccccaccgac     2280

ctgcagaaga tggtgatggg caacaccaag cccgtggagc tgatcctgga cggcaagacc     2340

gtggccatct gctgcgccac cggcgtgttc ggcaccgcct acctggtgcc ccgccacctg     2400

ttcgccgaga agtacgacaa gatcatgctg gacggccgcg ccatgaccga cagcgactac     2460

cgcgtgttcg agttcgagat caaggtgaag ggccaggaca tgctgagcga cgccgccctg     2520

atggtgctgc accgcggcaa ccgcgtgcgc gacatcacca agcacttccg cgacaccgcc     2580

cgcatgaaga agggcacccc cgtggtgggc gtgatcaaca acgccgacgt gggccgcctg     2640

atcttcagcg gcgaggccct gacctacaag gacatcgtgg tgtgcatgga cggcgacacc     2700

atgcccggcc tgttcgccta caaggccgcc accaaggccg gctactgcgg cggcgccgtg     2760

ctggccaagg acggcgccga caccttcatc gtgggcaccc acagcgccgg cggccgcaac     2820

ggcgtgggct actgcagctg cgtgagccgc agcatgctgc tgaagatgaa ggcccacatc     2880

gaccccgagc cccaccacga gggcctgatc gtggacaccc gcgacgtgga ggagcgcgtg     2940

cacgtgatgt ga                                                         2952


<210>  219
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT1 and consensus C3 amino acid

<400>  219

Met Leu Asp Val Asp Trp Gln Asp Arg Ala Gly Leu Phe Leu Arg Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Gln Ser Ala Phe Ser Gly Leu Val Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Met Thr Thr Ser His Gly Thr Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Ala Leu Ala Asp Lys Phe Leu Pro 
    130                 135                 140                 


Gly Pro Asn Thr Asn Gly Leu Glu Thr Arg Val Glu Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys His Lys Leu Phe Asp Trp Thr Thr Asp Gln Gln Phe Gly 
                165                 170                 175     


Thr Thr His Val Leu Glu Leu Pro Thr Asp His Lys Gly Ile Tyr Gly 
            180                 185                 190         


Gln Leu Val Asp Ser His Ala Tyr Ile Arg Asn Gly Trp Asp Val Gln 
        195                 200                 205             


Val Ser Ala Thr Ala Thr Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Leu Cys Lys Leu Asp Asp Arg Glu Lys Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Leu Asn Pro Arg Thr Asn Thr Thr Ala 
                245                 250                 255     


His Ile Gln Val Pro Tyr Leu Gly Val Asp Arg His Asp Gln Gly Thr 
            260                 265                 270         


Arg His Lys Ala Trp Thr Leu Val Val Met Val Val Ala Pro Tyr Thr 
        275                 280                 285             


Asn Asp Gln Thr Ile Gly Ser Thr Lys Ala Glu Val Tyr Val Asn Ile 
    290                 295                 300                 


Ala Pro Thr Asn Val Tyr Val Ala Gly Glu Lys Pro Ala Lys Gln Gly 
305                 310                 315                 320 


Ile Leu Pro Val Ala Val Ser Asp Gly Tyr Gly Gly Phe Gln Asn Thr 
                325                 330                 335     


Asp Pro Lys Thr Ser Asp Pro Ile Tyr Gly His Val Tyr Asn Pro Ala 
            340                 345                 350         


Arg Thr Leu Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala Glu 
        355                 360                 365             


Ala Cys Pro Thr Leu Leu Asp Phe Asn Gly Val Pro Tyr Val Gln Thr 
    370                 375                 380                 


Gln Asn Asn Ser Gly Ser Lys Val Leu Ala Arg Phe Asp Leu Ala Phe 
385                 390                 395                 400 


Gly His Lys Asn Met Lys Asn Thr Tyr Met Ser Gly Leu Ala Gln Tyr 
                405                 410                 415     


Phe Ala Gln Tyr Ser Gly Thr Leu Asn Leu His Phe Met Tyr Thr Gly 
            420                 425                 430         


Pro Thr Asn Asn Lys Ala Lys Tyr Met Val Ala Tyr Ile Pro Pro Gly 
        435                 440                 445             


Thr His Pro Leu Pro Glu Thr Pro Glu Met Ala Ser His Cys Tyr His 
    450                 455                 460                 


Ala Glu Trp Asp Thr Gly Leu Asn Ser Thr Phe Thr Phe Thr Val Pro 
465                 470                 475                 480 


Tyr Ile Ser Ala Ala Asp Tyr Ala Tyr Thr Tyr Ala Asp Glu Pro Glu 
                485                 490                 495     


Gln Ala Ser Val Gln Gly Trp Val Gly Val Tyr Gln Ile Thr Asp Thr 
            500                 505                 510         


His Glu Lys Asp Gly Ala Val Ile Val Thr Val Ser Ala Gly Pro Asp 
        515                 520                 525             


Phe Glu Phe Arg Met Pro Ile Ser Pro Ser Arg Gln Thr Thr Ser Ala 
    530                 535                 540                 


Gly Glu Gly Ala Asp Pro Val Thr Thr Asp Val Ser Glu His Gly Gly 
545                 550                 555                 560 


Asp Ser Arg Thr Ala Arg Arg Ala His Thr Asp Val Ala Phe Leu Leu 
                565                 570                 575     


Asp Arg Phe Thr Leu Val Gly Lys Thr Gln Asp Asn Lys Leu Val Leu 
            580                 585                 590         


Asp Leu Leu Thr Thr Lys Glu Lys Ser Leu Val Gly Ala Leu Leu Arg 
        595                 600                 605             


Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Val Ala Cys Val Gly Thr 
    610                 615                 620                 


Asn Lys Trp Val Gly Trp Thr Pro Asn Gly Ser Pro Val Lys Leu Ser 
625                 630                 635                 640 


Glu Val Gly Asp Asn Pro Val Val Phe Ser His Asn Gly Thr Thr Arg 
                645                 650                 655     


Phe Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr 
            660                 665                 670         


Asn Gly Asp Cys Lys Tyr Lys Pro Thr Gly Thr Pro Pro Arg Glu Asn 
        675                 680                 685             


Ile Arg Gly Asp Leu Ala Thr Leu Ala Ala Arg Ile Ala Ser Glu Thr 
    690                 695                 700                 


His Ile Pro Thr Thr Phe Asn Tyr Gly Met Ile Tyr Thr Glu Ala Glu 
705                 710                 715                 720 


Val Asp Val Tyr Leu Arg Met Lys Arg Ala Glu Leu Tyr Cys Val Lys 
                725                 730                 735     


Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Thr Leu Ile Val Thr 
            740                 745                 750         


Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met Val Met Gly Asn 
        755                 760                 765             


Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr Val Ala Ile Cys 
    770                 775                 780                 


Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val Pro Arg His Leu 
785                 790                 795                 800 


Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly Arg Ala Met Thr 
                805                 810                 815     


Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys Val Lys Gly Gln 
            820                 825                 830         


Asp Met Leu Ser Asp Ala Ala Leu Met Val Leu His Arg Gly Asn Arg 
        835                 840                 845             


Val Arg Asp Ile Thr Lys His Phe Arg Asp Thr Ala Arg Met Lys Lys 
    850                 855                 860                 


Gly Thr Pro Val Val Gly Val Ile Asn Asn Ala Asp Val Gly Arg Leu 
865                 870                 875                 880 


Ile Phe Ser Gly Glu Ala Leu Thr Tyr Lys Asp Ile Val Val Cys Met 
                885                 890                 895     


Asp Gly Asp Thr Met Pro Gly Leu Phe Ala Tyr Lys Ala Ala Thr Lys 
            900                 905                 910         


Ala Gly Tyr Cys Gly Gly Ala Val Leu Ala Lys Asp Gly Ala Asp Thr 
        915                 920                 925             


Phe Ile Val Gly Thr His Ser Ala Gly Gly Arg Asn Gly Val Gly Tyr 
    930                 935                 940                 


Cys Ser Cys Val Ser Arg Ser Met Leu Leu Lys Met Lys Ala His Ile 
945                 950                 955                 960 


Asp Pro Glu Pro His His Glu Gly Leu Ile Val Asp Thr Arg Asp Val 
                965                 970                 975     


Glu Glu Arg Val His Val Met 
            980             


<210>  220
<211>  2940
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT2 and consensus C3 nucleic acid

<400>  220
atgctggacg tggactggca ggacaaggcc ggcctgttcc tgcgcggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaacaacac ccagaacaac      240

gactggttca gcaagctggc ccagagcgcc atcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgccacggc      360

accaccacca gcaccaccca gagcagcgtg ggcatcacct acggctacgc cgacgccgac      420

agcttccgcc ccggccccaa caccagcggc ctggagaccc gcgtggagca ggccgagcgc      480

ttcttcaagg agaagctgtt cgactggacc agcgacaagc ccttcggcac cctgtacgtg      540

ctggagctgc ccaaggacca caagggcatc tacggcagcc tgaccgacgc ctacacctac      600

atgcgcaacg gctgggacgt gcaggtgagc gccaccagca cccagttcaa cggcggcagc      660

ctgctggtgg ccatggtgcc cgagctgtgc agcctgaagg accgcgagga gttccagctg      720

accctgtacc cccaccagtt catcaacccc cgcaccaaca ccaccgccca catccaggtg      780

ccctacctgg gcgtgaaccg ccacgaccag ggcaagcgcc accaggcctg gagcctggtg      840

gtgatggtgc tgacccccct gaccaccgag gcccagatga acagcggcac cgtggaggtg      900

tacgccaaca tcgcccccac caacgtgttc gtggccggcg agaagcccgc caagcagggc      960

atcatccccg tggcctgcgc cgacggctac ggcggcttcc agaacaccga ccccaagacc     1020

gccgacccca tctacggcta cgtgtacaac cccagccgca acgactgcca cggccgctac     1080

agcaacctgc tggacgtggc cgaggcctgc cccaccctgc tgaacttcga cggcaagccc     1140

tacgtggtga ccaagaacaa cggcgacaag gtgatggccg ccttcgacgt ggccttcacc     1200

cacaaggtgc acaagaacac cttcctggcc ggcctggccg actactacac ccagtaccag     1260

ggcagcctga actaccactt catgtacacc ggccccaccc accacaaggc caagttcatg     1320

gtggcctaca tcccccccgg catcgagacc gacaagctgc ccaagacccc cgaggacgcc     1380

gcccactgct accacagcga gtgggacacc ggcctgaaca gccagttcac cttcgccgtg     1440

ccctacgtga gcgccagcga cttcagctac acccacaccg acacccccgc catggccacc     1500

accaacggct gggtggccgt gttccaggtg accgacaccc acagcgccga ggccgccgtg     1560

gtggtgagcg tgagcgccgg ccccgacctg gagttccgct tccccatcga ccccgtgcgc     1620

cagaccacca gcgccggcga gggcgccgag gtggtgacca ccgaccccag cacccacggc     1680

ggcaaggtga ccgagaagcg ccgcgtgcac accgacgtgg ccttcgtgct ggaccgcttc     1740

acccacgtgc acaccaacaa gaccaccttc gccgtggacc tgatggacac caaggagaag     1800

accctggtgg gcgccctgct gcgcgccgcc acctactact tctgcgacct ggagatcgcc     1860

tgcgtgggcg agcacaagcg cgtgttctgg cagcccaacg gcgccccccg caccacccag     1920

ctgggcgaca accccatggt gttcagccac aacaaggtga cccgcttcgc catcccctac     1980

accgcccccc accgcctgct gagcaccgtg tacaacggcg agtgcgagta caccaagacc     2040

gtgaccgcca tccgcggcga ccgcgaggtg ctggccgcca agtacagcag cgccaagcac     2100

accctgccca gcaccttcaa cttcggcttc gtgaccgccg acgagcccgt ggacgtgtac     2160

taccgcatga agcgcgccga gctgtactgc gtgaagaagc ccgtggccct gaaggtgaag     2220

gccaagaaca ccctgatcgt gaccgagagc ggcgcccccc ccaccgacct gcagaagatg     2280

gtgatgggca acaccaagcc cgtggagctg atcctggacg gcaagaccgt ggccatctgc     2340

tgcgccaccg gcgtgttcgg caccgcctac ctggtgcccc gccacctgtt cgccgagaag     2400

tacgacaaga tcatgctgga cggccgcgcc atgaccgaca gcgactaccg cgtgttcgag     2460

ttcgagatca aggtgaaggg ccaggacatg ctgagcgacg ccgccctgat ggtgctgcac     2520

cgcggcaacc gcgtgcgcga catcaccaag cacttccgcg acaccgcccg catgaagaag     2580

ggcacccccg tggtgggcgt gatcaacaac gccgacgtgg gccgcctgat cttcagcggc     2640

gaggccctga cctacaagga catcgtggtg tgcatggacg gcgacaccat gcccggcctg     2700

ttcgcctaca aggccgccac caaggccggc tactgcggcg gcgccgtgct ggccaaggac     2760

ggcgccgaca ccttcatcgt gggcacccac agcgccggcg gccgcaacgg cgtgggctac     2820

tgcagctgcg tgagccgcag catgctgctg aagatgaagg cccacatcga ccccgagccc     2880

caccacgagg gcctgatcgt ggacacccgc gacgtggagg agcgcgtgca cgtgatgtga     2940


<210>  221
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT2 and consensus C3 amino acid

<400>  221

Met Leu Asp Val Asp Trp Gln Asp Lys Ala Gly Leu Phe Leu Arg Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Gln Ser Ala Ile Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg His Gly Thr Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Ile Thr Tyr Gly Tyr Ala Asp Ala Asp Ser Phe Arg Pro 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Glu Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Glu Lys Leu Phe Asp Trp Thr Ser Asp Lys Pro Phe Gly 
                165                 170                 175     


Thr Leu Tyr Val Leu Glu Leu Pro Lys Asp His Lys Gly Ile Tyr Gly 
            180                 185                 190         


Ser Leu Thr Asp Ala Tyr Thr Tyr Met Arg Asn Gly Trp Asp Val Gln 
        195                 200                 205             


Val Ser Ala Thr Ser Thr Gln Phe Asn Gly Gly Ser Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Leu Cys Ser Leu Lys Asp Arg Glu Glu Phe Gln Leu 
225                 230                 235                 240 


Thr Leu Tyr Pro His Gln Phe Ile Asn Pro Arg Thr Asn Thr Thr Ala 
                245                 250                 255     


His Ile Gln Val Pro Tyr Leu Gly Val Asn Arg His Asp Gln Gly Lys 
            260                 265                 270         


Arg His Gln Ala Trp Ser Leu Val Val Met Val Leu Thr Pro Leu Thr 
        275                 280                 285             


Thr Glu Ala Gln Met Asn Ser Gly Thr Val Glu Val Tyr Ala Asn Ile 
    290                 295                 300                 


Ala Pro Thr Asn Val Phe Val Ala Gly Glu Lys Pro Ala Lys Gln Gly 
305                 310                 315                 320 


Ile Ile Pro Val Ala Cys Ala Asp Gly Tyr Gly Gly Phe Gln Asn Thr 
                325                 330                 335     


Asp Pro Lys Thr Ala Asp Pro Ile Tyr Gly Tyr Val Tyr Asn Pro Ser 
            340                 345                 350         


Arg Asn Asp Cys His Gly Arg Tyr Ser Asn Leu Leu Asp Val Ala Glu 
        355                 360                 365             


Ala Cys Pro Thr Leu Leu Asn Phe Asp Gly Lys Pro Tyr Val Val Thr 
    370                 375                 380                 


Lys Asn Asn Gly Asp Lys Val Met Ala Ala Phe Asp Val Ala Phe Thr 
385                 390                 395                 400 


His Lys Val His Lys Asn Thr Phe Leu Ala Gly Leu Ala Asp Tyr Tyr 
                405                 410                 415     


Thr Gln Tyr Gln Gly Ser Leu Asn Tyr His Phe Met Tyr Thr Gly Pro 
            420                 425                 430         


Thr His His Lys Ala Lys Phe Met Val Ala Tyr Ile Pro Pro Gly Ile 
        435                 440                 445             


Glu Thr Asp Lys Leu Pro Lys Thr Pro Glu Asp Ala Ala His Cys Tyr 
    450                 455                 460                 


His Ser Glu Trp Asp Thr Gly Leu Asn Ser Gln Phe Thr Phe Ala Val 
465                 470                 475                 480 


Pro Tyr Val Ser Ala Ser Asp Phe Ser Tyr Thr His Thr Asp Thr Pro 
                485                 490                 495     


Ala Met Ala Thr Thr Asn Gly Trp Val Ala Val Phe Gln Val Thr Asp 
            500                 505                 510         


Thr His Ser Ala Glu Ala Ala Val Val Val Ser Val Ser Ala Gly Pro 
        515                 520                 525             


Asp Leu Glu Phe Arg Phe Pro Ile Asp Pro Val Arg Gln Thr Thr Ser 
    530                 535                 540                 


Ala Gly Glu Gly Ala Glu Val Val Thr Thr Asp Pro Ser Thr His Gly 
545                 550                 555                 560 


Gly Lys Val Thr Glu Lys Arg Arg Val His Thr Asp Val Ala Phe Val 
                565                 570                 575     


Leu Asp Arg Phe Thr His Val His Thr Asn Lys Thr Thr Phe Ala Val 
            580                 585                 590         


Asp Leu Met Asp Thr Lys Glu Lys Thr Leu Val Gly Ala Leu Leu Arg 
        595                 600                 605             


Ala Ala Thr Tyr Tyr Phe Cys Asp Leu Glu Ile Ala Cys Val Gly Glu 
    610                 615                 620                 


His Lys Arg Val Phe Trp Gln Pro Asn Gly Ala Pro Arg Thr Thr Gln 
625                 630                 635                 640 


Leu Gly Asp Asn Pro Met Val Phe Ser His Asn Lys Val Thr Arg Phe 
                645                 650                 655     


Ala Ile Pro Tyr Thr Ala Pro His Arg Leu Leu Ser Thr Val Tyr Asn 
            660                 665                 670         


Gly Glu Cys Glu Tyr Thr Lys Thr Val Thr Ala Ile Arg Gly Asp Arg 
        675                 680                 685             


Glu Val Leu Ala Ala Lys Tyr Ser Ser Ala Lys His Thr Leu Pro Ser 
    690                 695                 700                 


Thr Phe Asn Phe Gly Phe Val Thr Ala Asp Glu Pro Val Asp Val Tyr 
705                 710                 715                 720 


Tyr Arg Met Lys Arg Ala Glu Leu Tyr Cys Val Lys Lys Pro Val Ala 
                725                 730                 735     


Leu Lys Val Lys Ala Lys Asn Thr Leu Ile Val Thr Glu Ser Gly Ala 
            740                 745                 750         


Pro Pro Thr Asp Leu Gln Lys Met Val Met Gly Asn Thr Lys Pro Val 
        755                 760                 765             


Glu Leu Ile Leu Asp Gly Lys Thr Val Ala Ile Cys Cys Ala Thr Gly 
    770                 775                 780                 


Val Phe Gly Thr Ala Tyr Leu Val Pro Arg His Leu Phe Ala Glu Lys 
785                 790                 795                 800 


Tyr Asp Lys Ile Met Leu Asp Gly Arg Ala Met Thr Asp Ser Asp Tyr 
                805                 810                 815     


Arg Val Phe Glu Phe Glu Ile Lys Val Lys Gly Gln Asp Met Leu Ser 
            820                 825                 830         


Asp Ala Ala Leu Met Val Leu His Arg Gly Asn Arg Val Arg Asp Ile 
        835                 840                 845             


Thr Lys His Phe Arg Asp Thr Ala Arg Met Lys Lys Gly Thr Pro Val 
    850                 855                 860                 


Val Gly Val Ile Asn Asn Ala Asp Val Gly Arg Leu Ile Phe Ser Gly 
865                 870                 875                 880 


Glu Ala Leu Thr Tyr Lys Asp Ile Val Val Cys Met Asp Gly Asp Thr 
                885                 890                 895     


Met Pro Gly Leu Phe Ala Tyr Lys Ala Ala Thr Lys Ala Gly Tyr Cys 
            900                 905                 910         


Gly Gly Ala Val Leu Ala Lys Asp Gly Ala Asp Thr Phe Ile Val Gly 
        915                 920                 925             


Thr His Ser Ala Gly Gly Arg Asn Gly Val Gly Tyr Cys Ser Cys Val 
    930                 935                 940                 


Ser Arg Ser Met Leu Leu Lys Met Lys Ala His Ile Asp Pro Glu Pro 
945                 950                 955                 960 


His His Glu Gly Leu Ile Val Asp Thr Arg Asp Val Glu Glu Arg Val 
                965                 970                 975     


His Val Met 
            


<210>  222
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT3 and consensus C3 nucleic acid

<400>  222
atgctggacg tggactggca ggaccgcgcc ggcctgttcc tgcgcggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaacaacac ccagaacaac      240

gactggttca gcaagctggc ccagagcgcc atcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac cacccacctg gaggaccgca tcctgaccac ccgccacaac      360

accaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacgt gagcgccgac      420

cgcttcctgc ccggccccaa caccagcggc ctggagagcc gcgtggagca ggccgagcgc      480

ttcttcaagg agaagctgtt cacctggacc gccagccagg agtacgccca cgtgcacctg      540

ctggagctgc ccaccgacca caagggcatc tacggcgcca tggtggacag ccacgcctac      600

gtgcgcaacg gctgggacgt gcaggtgacc gccaccagca cccagttcaa cggcggcacc      660

ctgctggtgg ccatggtgcc cgagctgcac agcctggaca cccgcgacgt gagccagctg      720

accctgttcc cccaccagtt catcaacccc cgcaccaaca ccaccgccca catcgtggtg      780

ccctacgtgg gcgtgaaccg ccacgaccag gtgcagatgc acaaggcctg gaccctggtg      840

gtggccgtga tggcccccct gaccaccagc agcatgggcc aggacaacgt ggaggtgtac      900

gccaacatcg cccccaccaa cgtgtacgtg gccggcgagc gccccagcaa gcagggcatc      960

atccccgtgg cctgcaacga cggctacggc ggcttccaga acaccgaccc caagaccgcc     1020

gaccccatct acggcctggt gagcaacccc ccccgcaccg ccttccccgg ccgcttcacc     1080

aacctgctgg acgtggccga ggcctgcccc accttcctgg acttcgacgg cgtgccctac     1140

gtgaagacca cccacaacag cggcagcaag atcctgaccc acatcgacct ggccttcggc     1200

cacaagagct tcaagaacac ctacctggcc ggcctggccc agtactacgc ccagtacagc     1260

ggcagcatca acctgcactt catgtacacc ggccccaccc agagcaaggc ccgcttcatg     1320

gtggcctaca tcccccccgg caccaccgtg cccaacaccc ccgagcaggc cgcccactgc     1380

taccacagcg agtgggacac cggcctgaac agcaagttca ccttcaccgt gccctacatg     1440

agcgccgccg acttcgccta cacctactgc gacgagcccg agcaggccag cgcccagggc     1500

tgggtgaccc tgtaccagat caccgacacc cacgaccccg acagcgccgt gctggtgagc     1560

gtgagcgccg gcgccgactt cgagctgcgc ctgcccatca accccgccgc ccagaccacc     1620

agcgccggcg agggcgccga cgtggtgacc accgacgtga ccacccacgg cggcgaggtg     1680

agcgtgcccc gccgccagca caccaacgtg gagttcctgc tggaccgctt cacccacatc     1740

ggcaccatca acggccaccg caccatctgc ctgatggaca ccaaggagca caccctggtg     1800

ggcgccatcc tgcgcagcgc cacctactac ttctgcgacc tggaggtggc cgtgctgggc     1860

aacgccaagt acgccgcctg ggtgcccaac ggctgccccc acaccgaccg cgtggaggac     1920

aaccccgtgg tgcacagcaa gggcagcgtg gtgcgcttcg ccctgcccta caccgccccc     1980

cacggcgtgc tggccaccgt gtacaacggc aactgcaagt acagcaccac ccagcgcgtg     2040

gccccccgcc gcggcgacct gggcgtgctg agccagcgcg tggagaacga gaccacccgc     2100

tgcatcccca ccaccttcaa cttcggccgc ctgctgtgcg agagcggcga cgtgtactac     2160

cgcatgaagc gcaccgagct gtactgcgtg aagaagcccg tggccctgaa ggtgaaggcc     2220

aagaacaccc tgatcgtgac cgagagcggc gcccccccca ccgacctgca gaagatggtg     2280

atgggcaaca ccaagcccgt ggagctgatc ctggacggca agaccgtggc catctgctgc     2340

gccaccggcg tgttcggcac cgcctacctg gtgccccgcc acctgttcgc cgagaagtac     2400

gacaagatca tgctggacgg ccgcgccatg accgacagcg actaccgcgt gttcgagttc     2460

gagatcaagg tgaagggcca ggacatgctg agcgacgccg ccctgatggt gctgcaccgc     2520

ggcaaccgcg tgcgcgacat caccaagcac ttccgcgaca ccgcccgcat gaagaagggc     2580

acccccgtgg tgggcgtgat caacaacgcc gacgtgggcc gcctgatctt cagcggcgag     2640

gccctgacct acaaggacat cgtggtgtgc atggacggcg acaccatgcc cggcctgttc     2700

gcctacaagg ccgccaccaa ggccggctac tgcggcggcg ccgtgctggc caaggacggc     2760

gccgacacct tcatcgtggg cacccacagc gccggcggcc gcaacggcgt gggctactgc     2820

agctgcgtga gccgcagcat gctgctgaag atgaaggccc acatcgaccc cgagccccac     2880

cacgagggcc tgatcgtgga cacccgcgac gtggaggagc gcgtgcacgt gatgtga        2937


<210>  223
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT3 and consensus C3 amino acid

<400>  223

Met Leu Asp Val Asp Trp Gln Asp Arg Ala Gly Leu Phe Leu Arg Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Gln Ser Ala Ile Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr His Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg His Asn Thr Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Val Ser Ala Asp Arg Phe Leu Pro 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Ser Arg Val Glu Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Glu Lys Leu Phe Thr Trp Thr Ala Ser Gln Glu Tyr Ala 
                165                 170                 175     


His Val His Leu Leu Glu Leu Pro Thr Asp His Lys Gly Ile Tyr Gly 
            180                 185                 190         


Ala Met Val Asp Ser His Ala Tyr Val Arg Asn Gly Trp Asp Val Gln 
        195                 200                 205             


Val Thr Ala Thr Ser Thr Gln Phe Asn Gly Gly Thr Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Leu His Ser Leu Asp Thr Arg Asp Val Ser Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Thr Thr Ala 
                245                 250                 255     


His Ile Val Val Pro Tyr Val Gly Val Asn Arg His Asp Gln Val Gln 
            260                 265                 270         


Met His Lys Ala Trp Thr Leu Val Val Ala Val Met Ala Pro Leu Thr 
        275                 280                 285             


Thr Ser Ser Met Gly Gln Asp Asn Val Glu Val Tyr Ala Asn Ile Ala 
    290                 295                 300                 


Pro Thr Asn Val Tyr Val Ala Gly Glu Arg Pro Ser Lys Gln Gly Ile 
305                 310                 315                 320 


Ile Pro Val Ala Cys Asn Asp Gly Tyr Gly Gly Phe Gln Asn Thr Asp 
                325                 330                 335     


Pro Lys Thr Ala Asp Pro Ile Tyr Gly Leu Val Ser Asn Pro Pro Arg 
            340                 345                 350         


Thr Ala Phe Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala Glu Ala 
        355                 360                 365             


Cys Pro Thr Phe Leu Asp Phe Asp Gly Val Pro Tyr Val Lys Thr Thr 
    370                 375                 380                 


His Asn Ser Gly Ser Lys Ile Leu Thr His Ile Asp Leu Ala Phe Gly 
385                 390                 395                 400 


His Lys Ser Phe Lys Asn Thr Tyr Leu Ala Gly Leu Ala Gln Tyr Tyr 
                405                 410                 415     


Ala Gln Tyr Ser Gly Ser Ile Asn Leu His Phe Met Tyr Thr Gly Pro 
            420                 425                 430         


Thr Gln Ser Lys Ala Arg Phe Met Val Ala Tyr Ile Pro Pro Gly Thr 
        435                 440                 445             


Thr Val Pro Asn Thr Pro Glu Gln Ala Ala His Cys Tyr His Ser Glu 
    450                 455                 460                 


Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Thr Val Pro Tyr Met 
465                 470                 475                 480 


Ser Ala Ala Asp Phe Ala Tyr Thr Tyr Cys Asp Glu Pro Glu Gln Ala 
                485                 490                 495     


Ser Ala Gln Gly Trp Val Thr Leu Tyr Gln Ile Thr Asp Thr His Asp 
            500                 505                 510         


Pro Asp Ser Ala Val Leu Val Ser Val Ser Ala Gly Ala Asp Phe Glu 
        515                 520                 525             


Leu Arg Leu Pro Ile Asn Pro Ala Ala Gln Thr Thr Ser Ala Gly Glu 
    530                 535                 540                 


Gly Ala Asp Val Val Thr Thr Asp Val Thr Thr His Gly Gly Glu Val 
545                 550                 555                 560 


Ser Val Pro Arg Arg Gln His Thr Asn Val Glu Phe Leu Leu Asp Arg 
                565                 570                 575     


Phe Thr His Ile Gly Thr Ile Asn Gly His Arg Thr Ile Cys Leu Met 
            580                 585                 590         


Asp Thr Lys Glu His Thr Leu Val Gly Ala Ile Leu Arg Ser Ala Thr 
        595                 600                 605             


Tyr Tyr Phe Cys Asp Leu Glu Val Ala Val Leu Gly Asn Ala Lys Tyr 
    610                 615                 620                 


Ala Ala Trp Val Pro Asn Gly Cys Pro His Thr Asp Arg Val Glu Asp 
625                 630                 635                 640 


Asn Pro Val Val His Ser Lys Gly Ser Val Val Arg Phe Ala Leu Pro 
                645                 650                 655     


Tyr Thr Ala Pro His Gly Val Leu Ala Thr Val Tyr Asn Gly Asn Cys 
            660                 665                 670         


Lys Tyr Ser Thr Thr Gln Arg Val Ala Pro Arg Arg Gly Asp Leu Gly 
        675                 680                 685             


Val Leu Ser Gln Arg Val Glu Asn Glu Thr Thr Arg Cys Ile Pro Thr 
    690                 695                 700                 


Thr Phe Asn Phe Gly Arg Leu Leu Cys Glu Ser Gly Asp Val Tyr Tyr 
705                 710                 715                 720 


Arg Met Lys Arg Thr Glu Leu Tyr Cys Val Lys Lys Pro Val Ala Leu 
                725                 730                 735     


Lys Val Lys Ala Lys Asn Thr Leu Ile Val Thr Glu Ser Gly Ala Pro 
            740                 745                 750         


Pro Thr Asp Leu Gln Lys Met Val Met Gly Asn Thr Lys Pro Val Glu 
        755                 760                 765             


Leu Ile Leu Asp Gly Lys Thr Val Ala Ile Cys Cys Ala Thr Gly Val 
    770                 775                 780                 


Phe Gly Thr Ala Tyr Leu Val Pro Arg His Leu Phe Ala Glu Lys Tyr 
785                 790                 795                 800 


Asp Lys Ile Met Leu Asp Gly Arg Ala Met Thr Asp Ser Asp Tyr Arg 
                805                 810                 815     


Val Phe Glu Phe Glu Ile Lys Val Lys Gly Gln Asp Met Leu Ser Asp 
            820                 825                 830         


Ala Ala Leu Met Val Leu His Arg Gly Asn Arg Val Arg Asp Ile Thr 
        835                 840                 845             


Lys His Phe Arg Asp Thr Ala Arg Met Lys Lys Gly Thr Pro Val Val 
    850                 855                 860                 


Gly Val Ile Asn Asn Ala Asp Val Gly Arg Leu Ile Phe Ser Gly Glu 
865                 870                 875                 880 


Ala Leu Thr Tyr Lys Asp Ile Val Val Cys Met Asp Gly Asp Thr Met 
                885                 890                 895     


Pro Gly Leu Phe Ala Tyr Lys Ala Ala Thr Lys Ala Gly Tyr Cys Gly 
            900                 905                 910         


Gly Ala Val Leu Ala Lys Asp Gly Ala Asp Thr Phe Ile Val Gly Thr 
        915                 920                 925             


His Ser Ala Gly Gly Arg Asn Gly Val Gly Tyr Cys Ser Cys Val Ser 
    930                 935                 940                 


Arg Ser Met Leu Leu Lys Met Lys Ala His Ile Asp Pro Glu Pro His 
945                 950                 955                 960 


His Glu Gly Leu Ile Val Asp Thr Arg Asp Val Glu Glu Arg Val His 
                965                 970                 975     


Val Met 
        


<210>  224
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus C3 amino acid

<400>  224
tactgcgtga agaagcccgt ggccctgaag gtgaaggcca agaacaccct gatcgtgacc       60

gagagcggcg ccccccccac cgacctgcag aagatggtga tgggcaacac caagcccgtg      120

gagctgatcc tggacggcaa gaccgtggcc atctgctgcg ccaccggcgt gttcggcacc      180

gcctacctgg tgccccgcca cctgttcgcc gagaagtacg acaagatcat gctggacggc      240

cgcgccatga ccgacagcga ctaccgcgtg ttcgagttcg agatcaaggt gaagggccag      300

gacatgctga gcgacgccgc cctgatggtg ctgcaccgcg gcaaccgcgt gcgcgacatc      360

accaagcact tccgcgacac cgcccgcatg aagaagggca cccccgtggt gggcgtgatc      420

aacaacgccg acgtgggccg cctgatcttc agcggcgagg ccctgaccta caaggacatc      480

gtggtgtgca tggacggcga caccatgccc ggcctgttcg cctacaaggc cgccaccaag      540

gccggctact gcggcggcgc cgtgctggcc aaggacggcg ccgacacctt catcgtgggc      600

acccacagcg ccggcggccg caacggcgtg ggctactgca gctgcgtgag ccgcagcatg      660

ctgctgaaga tgaaggccca catcgacccc gagccccacc acgagggcct gatcgtggac      720

acccgcgacg tggaggagcg cgtgcacgtg atgtga                                756


<210>  225
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus C3  amino acid

<400>  225

Tyr Cys Val Lys Lys Pro Val Ala Leu Lys Val Lys Ala Lys Asn Thr 
1               5                   10                  15      


Leu Ile Val Thr Glu Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met 
            20                  25                  30          


Val Met Gly Asn Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr 
        35                  40                  45              


Val Ala Ile Cys Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val 
    50                  55                  60                  


Pro Arg His Leu Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly 
65                  70                  75                  80  


Arg Ala Met Thr Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys 
                85                  90                  95      


Val Lys Gly Gln Asp Met Leu Ser Asp Ala Ala Leu Met Val Leu His 
            100                 105                 110         


Arg Gly Asn Arg Val Arg Asp Ile Thr Lys His Phe Arg Asp Thr Ala 
        115                 120                 125             


Arg Met Lys Lys Gly Thr Pro Val Val Gly Val Ile Asn Asn Ala Asp 
    130                 135                 140                 


Val Gly Arg Leu Ile Phe Ser Gly Glu Ala Leu Thr Tyr Lys Asp Ile 
145                 150                 155                 160 


Val Val Cys Met Asp Gly Asp Thr Met Pro Gly Leu Phe Ala Tyr Lys 
                165                 170                 175     


Ala Ala Thr Lys Ala Gly Tyr Cys Gly Gly Ala Val Leu Ala Lys Asp 
            180                 185                 190         


Gly Ala Asp Thr Phe Ile Val Gly Thr His Ser Ala Gly Gly Arg Asn 
        195                 200                 205             


Gly Val Gly Tyr Cys Ser Cys Val Ser Arg Ser Met Leu Leu Lys Met 
    210                 215                 220                 


Lys Ala His Ile Asp Pro Glu Pro His His Glu Gly Leu Ile Val Asp 
225                 230                 235                 240 


Thr Arg Asp Val Glu Glu Arg Val His Val Met 
                245                 250     


<210>  226
<211>  2160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype A nucleic acid

<400>  226
atgctgaacg gcgactggaa ggccaaggtg cagcgcaagc tgaagggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaccaacac ccagaacaac      240

gactggttca gcaagctggc cagcagcgcc ttcaccggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgcaacggc      360

cacaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacag caccaccgag      420

gaccacgtgg ccggccccaa caccagcggc ctggagaccc gcgtggtgca ggccgagcgc      480

ttcttcaaga agttcctgtt cgactggacc accgacaagc ccttcggcca cctgcacaag      540

ctggagctgc ccaccgacca ccacggcgtg ttcggccacc tggtggacag ctacgcctac      600

atgcgcaacg gctgggacgt ggaggtgagc gccgtgggca accagttcaa cggcggctgc      660

ctgctggtgg ccatggtgcc cgagtggaag gagttcgaca cccgcgagaa gtaccagctg      720

accctgttcc cccaccagtt catcagcccc cgcaccaaca tgaccgccca catcaccgtg      780

ccctacctgg gcgtgaaccg ctacgaccag tacaagaagc acaagccctg gaccctggtg      840

gtgatggtgg tgagccccct gaccgtgaac accgccgccc agatcaaggt gtacgccaac      900

atcgccccca cctacgtgca cgtggccggc gagctgccca gcaaggaggg catcttcccc      960

gtggcctgcg ccgacggcta cggcggcctg gtgaccaccg accccaagac cgccgacccc     1020

gcctacggca aggtgtacaa ccccccccgc accaactacc ccggccgctt caccaacctg     1080

ctggacgtgg ccgaggcctg ccccaccttc ctgtgcttcg acgacggcaa gccctacgtg     1140

accacccgca ccgacgagac ccgcctgctg gccaagttcg acgtgagcct ggccgccaag     1200

cacatgagca acacctacct gagcggcatc gcccagtact acacccagta cagcggcacc     1260

atcaacctgc acttcatgtt caccggcagc accgacagca aggcccgcta catggtggcc     1320

tacatccccc ccggcgtgga gacccccccc gacacccccg agcgcgccgc ccactgcatc     1380

cacgccgagt gggacaccgg cctgaacagc aagttcacct tcagcatccc ctacgtgagc     1440

gccgccgact acgcctacac cgccagcgac accgccgaga ccaccaacgt gcagggctgg     1500

gtgtgcgtgt accagatcac ccacggcaag gccgagaacg acaccctggt ggtgagcgtg     1560

agcgccggca aggacttcga gctgcgcctg cccatcgacc cccgccagca gaccaccgcc     1620

accggcgaga gcgccgaccc cgtgaccacc accgtggaga actacggcgg cgagacccag     1680

gtgcagcgcc gccaccacac cgacgtgggc ttcatcatgg accgcttcgt gaagatcaac     1740

agccccaagc ccacccacgt gatcgacctg atgcagaccc accagcacgg cctggtgggc     1800

gccctgctgc gcgccgccac ctactacttc agcgacctgg agatcgtggt gcgccacgac     1860

ggcctgacct gggtgcccaa cggcgccccc gagagcgccc tgagcaacac cagcaacccc     1920

accgcctaca acaaggcccc cttcacccgc ctggccctgc cctacaccgc cccccaccgc     1980

gtgctggcca ccgtgtacaa cggcaccagc aagtacaccg tgagcggcag cagccgccgc     2040

ggcgacctgg gcagcctggc cgcccgcgtg gccaagcagc tgcccgccag cttcaactac     2100

ggcgccatca aggccgacac catccacgag ctgctggtgc gcatgaagcg cgccgagctg     2160


<210>  227
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype A amino acid

<400>  227

Met Leu Asn Gly Asp Trp Lys Ala Lys Val Gln Arg Lys Leu Lys Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Thr Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Ser Thr Thr Glu Asp His Val Ala 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Lys Phe Leu Phe Asp Trp Thr Thr Asp Lys Pro Phe Gly 
                165                 170                 175     


His Leu His Lys Leu Glu Leu Pro Thr Asp His His Gly Val Phe Gly 
            180                 185                 190         


His Leu Val Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu 
        195                 200                 205             


Val Ser Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Trp Lys Glu Phe Asp Thr Arg Glu Lys Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Ile Ser Pro Arg Thr Asn Met Thr Ala 
                245                 250                 255     


His Ile Thr Val Pro Tyr Leu Gly Val Asn Arg Tyr Asp Gln Tyr Lys 
            260                 265                 270         


Lys His Lys Pro Trp Thr Leu Val Val Met Val Val Ser Pro Leu Thr 
        275                 280                 285             


Val Asn Thr Ala Ala Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr 
    290                 295                 300                 


Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu Gly Ile Phe Pro 
305                 310                 315                 320 


Val Ala Cys Ala Asp Gly Tyr Gly Gly Leu Val Thr Thr Asp Pro Lys 
                325                 330                 335     


Thr Ala Asp Pro Ala Tyr Gly Lys Val Tyr Asn Pro Pro Arg Thr Asn 
            340                 345                 350         


Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala Glu Ala Cys Pro 
        355                 360                 365             


Thr Phe Leu Cys Phe Asp Asp Gly Lys Pro Tyr Val Thr Thr Arg Thr 
    370                 375                 380                 


Asp Glu Thr Arg Leu Leu Ala Lys Phe Asp Val Ser Leu Ala Ala Lys 
385                 390                 395                 400 


His Met Ser Asn Thr Tyr Leu Ser Gly Ile Ala Gln Tyr Tyr Thr Gln 
                405                 410                 415     


Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr Gly Ser Thr Asp 
            420                 425                 430         


Ser Lys Ala Arg Tyr Met Val Ala Tyr Ile Pro Pro Gly Val Glu Thr 
        435                 440                 445             


Pro Pro Asp Thr Pro Glu Arg Ala Ala His Cys Ile His Ala Glu Trp 
    450                 455                 460                 


Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Val Ser 
465                 470                 475                 480 


Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala Glu Thr Thr Asn 
                485                 490                 495     


Val Gln Gly Trp Val Cys Val Tyr Gln Ile Thr His Gly Lys Ala Glu 
            500                 505                 510         


Asn Asp Thr Leu Val Val Ser Val Ser Ala Gly Lys Asp Phe Glu Leu 
        515                 520                 525             


Arg Leu Pro Ile Asp Pro Arg Gln Gln Thr Thr Ala Thr Gly Glu Ser 
    530                 535                 540                 


Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln 
545                 550                 555                 560 


Val Gln Arg Arg His His Thr Asp Val Gly Phe Ile Met Asp Arg Phe 
                565                 570                 575     


Val Lys Ile Asn Ser Pro Lys Pro Thr His Val Ile Asp Leu Met Gln 
            580                 585                 590         


Thr His Gln His Gly Leu Val Gly Ala Leu Leu Arg Ala Ala Thr Tyr 
        595                 600                 605             


Tyr Phe Ser Asp Leu Glu Ile Val Val Arg His Asp Gly Leu Thr Trp 
    610                 615                 620                 


Val Pro Asn Gly Ala Pro Glu Ser Ala Leu Ser Asn Thr Ser Asn Pro 
625                 630                 635                 640 


Thr Ala Tyr Asn Lys Ala Pro Phe Thr Arg Leu Ala Leu Pro Tyr Thr 
                645                 650                 655     


Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Thr Ser Lys Tyr 
            660                 665                 670         


Thr Val Ser Gly Ser Ser Arg Arg Gly Asp Leu Gly Ser Leu Ala Ala 
        675                 680                 685             


Arg Val Ala Lys Gln Leu Pro Ala Ser Phe Asn Tyr Gly Ala Ile Lys 
    690                 695                 700                 


Ala Asp Thr Ile His Glu Leu Leu Val Arg Met Lys Arg Ala Glu Leu 
705                 710                 715                 720 


<210>  228
<211>  2160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype Asia1 nucleic acid

<400>  228
atgctgaacg gcgagtggaa ggccaaggtg cagaagcgcc tgaagggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaacaacac ccagaacaac      240

gactggttca gccgcctggc cagcagcgcc ttcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgcaacggc      360

cacaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacgc cgtggccgag      420

gacgccgtga gcggccccaa caccagcggc ctggagaccc gcgtgcagca ggccgagcgc      480

ttcttcaaga agcacctgtt cgactggacc cccaacctgg ccttcggcca ctgccactac      540

ctggagctgc ccaccgagca caagggcgtg tacggcagcc tgatggacag ctacgcctac      600

atgcgcaacg gctgggacat cgaggtgacc gccgtgggca accagttcaa cggcggctgc      660

ctgctggtgg ccctggtgcc cgagctgaag agcctggaca cccgccagaa gtaccagctg      720

accctgttcc cccaccagtt catcaacccc cgcaccaaca tgaccgccca catcaacgtg      780

cccttcgtgg gcgtgaaccg ctacgaccag tacgccctgc acaagccctg gaccctggtg      840

gtgatggtgg tggcccccct gaccgtgaag accggcggca gcgagcagat caaggtgtac      900

atgaacgccg cccccaccta cgtgcacgtg gccggcgagc tgcccagcaa ggagggcatc      960

gtgcccgtgg cctgcgccga cggctacggc aacatggtga ccaccgaccc caagaccgcc     1020

gaccccgtgt acggcaaggt gttcaacccc ccccgcacca acctgcccgg ccgcttcacc     1080

aacttcctgg acgtggccga ggcctgcccc accttcctgc gcttcggcga ggtgcccttc     1140

gtgaagaccg tgaacagcgg cgaccgcctg ctggccaagt tcgacgtgag cctggccgcc     1200

ggccacatga gcaacaccta cctggccggc ctggcccagt actacaccca gtacagcggc     1260

accatgaacg tgcacttcat gttcaccggc cccaccgacg ccaaggcccg ctacatggtg     1320

gcctacatcc cccccggcat gacccccccc accgaccccg agcgcgccgc ccactgcatc     1380

cacagcgagt gggacaccgg cctgaacagc aagttcacct tcagcatccc ctacctgagc     1440

gccgccgact acgcctacac cgccagcgac accgccgaga ccaccagcgt gcagggctgg     1500

gtgtgcatct accagatcac ccacggcaag gccgagggcg acgccctggt ggtgagcgtg     1560

agcgccggca aggacttcga gttccgcctg cccgtggacg cccgccgcca gaccaccacc     1620

accggcgaga gcgccgaccc cgtgaccacc accgtggaga actacggcgg cgagacccag     1680

accgcccgcc gcctgcacac cgacgtggcc ttcgtgctgg accgcttcgt gaagctgacc     1740

gcccccaaga acacccagac cctggacctg atgcagatcc ccagccacac cctggtgggc     1800

gccctgctgc gcagcgccac ctactacttc agcgacctgg aggtggccct ggtgcacacc     1860

ggccccgtga cctgggtgcc caacggcagc cccaaggacg ccctggacaa ccagaccaac     1920

cccaccgcct accagaagca gcccatcacc cgcctggccc tgccctacac cgccccccac     1980

cgcgtgctgg ccaccgtgta caacggcaag accacctacg gcgagacccc cagccgccgc     2040

ggcgacatgg ccgccctggc ccagcgcctg agcgagcgcc tgcccaccag cttcaactac     2100

ggcgccgtga aggccgagac catcaccgag ctgctgatcc gcatgaagcg cgccgagacc     2160


<210>  229
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype Asia 1 amino acid

<400>  229

Met Leu Asn Gly Glu Trp Lys Ala Lys Val Gln Lys Arg Leu Lys Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Arg Leu Ala Ser Ser Ala Phe Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Ala Val Ala Glu Asp Ala Val Ser 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Gln Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Lys His Leu Phe Asp Trp Thr Pro Asn Leu Ala Phe Gly 
                165                 170                 175     


His Cys His Tyr Leu Glu Leu Pro Thr Glu His Lys Gly Val Tyr Gly 
            180                 185                 190         


Ser Leu Met Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Ile Glu 
        195                 200                 205             


Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Leu Val Pro Glu Leu Lys Ser Leu Asp Thr Arg Gln Lys Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala 
                245                 250                 255     


His Ile Asn Val Pro Phe Val Gly Val Asn Arg Tyr Asp Gln Tyr Ala 
            260                 265                 270         


Leu His Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr 
        275                 280                 285             


Val Lys Thr Gly Gly Ser Glu Gln Ile Lys Val Tyr Met Asn Ala Ala 
    290                 295                 300                 


Pro Thr Tyr Val His Val Ala Gly Glu Leu Pro Ser Lys Glu Gly Ile 
305                 310                 315                 320 


Val Pro Val Ala Cys Ala Asp Gly Tyr Gly Asn Met Val Thr Thr Asp 
                325                 330                 335     


Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Phe Asn Pro Pro Arg 
            340                 345                 350         


Thr Asn Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val Ala Glu Ala 
        355                 360                 365             


Cys Pro Thr Phe Leu Arg Phe Gly Glu Val Pro Phe Val Lys Thr Val 
    370                 375                 380                 


Asn Ser Gly Asp Arg Leu Leu Ala Lys Phe Asp Val Ser Leu Ala Ala 
385                 390                 395                 400 


Gly His Met Ser Asn Thr Tyr Leu Ala Gly Leu Ala Gln Tyr Tyr Thr 
                405                 410                 415     


Gln Tyr Ser Gly Thr Met Asn Val His Phe Met Phe Thr Gly Pro Thr 
            420                 425                 430         


Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Ile Pro Pro Gly Met Thr 
        435                 440                 445             


Pro Pro Thr Asp Pro Glu Arg Ala Ala His Cys Ile His Ser Glu Trp 
    450                 455                 460                 


Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Leu Ser 
465                 470                 475                 480 


Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Thr Ala Glu Thr Thr Ser 
                485                 490                 495     


Val Gln Gly Trp Val Cys Ile Tyr Gln Ile Thr His Gly Lys Ala Glu 
            500                 505                 510         


Gly Asp Ala Leu Val Val Ser Val Ser Ala Gly Lys Asp Phe Glu Phe 
        515                 520                 525             


Arg Leu Pro Val Asp Ala Arg Arg Gln Thr Thr Thr Thr Gly Glu Ser 
    530                 535                 540                 


Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln 
545                 550                 555                 560 


Thr Ala Arg Arg Leu His Thr Asp Val Ala Phe Val Leu Asp Arg Phe 
                565                 570                 575     


Val Lys Leu Thr Ala Pro Lys Asn Thr Gln Thr Leu Asp Leu Met Gln 
            580                 585                 590         


Ile Pro Ser His Thr Leu Val Gly Ala Leu Leu Arg Ser Ala Thr Tyr 
        595                 600                 605             


Tyr Phe Ser Asp Leu Glu Val Ala Leu Val His Thr Gly Pro Val Thr 
    610                 615                 620                 


Trp Val Pro Asn Gly Ser Pro Lys Asp Ala Leu Asp Asn Gln Thr Asn 
625                 630                 635                 640 


Pro Thr Ala Tyr Gln Lys Gln Pro Ile Thr Arg Leu Ala Leu Pro Tyr 
                645                 650                 655     


Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Lys Thr Thr 
            660                 665                 670         


Tyr Gly Glu Thr Pro Ser Arg Arg Gly Asp Met Ala Ala Leu Ala Gln 
        675                 680                 685             


Arg Leu Ser Glu Arg Leu Pro Thr Ser Phe Asn Tyr Gly Ala Val Lys 
    690                 695                 700                 


Ala Glu Thr Ile Thr Glu Leu Leu Ile Arg Met Lys Arg Ala Glu Thr 
705                 710                 715                 720 


<210>  230
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype C nucleic acid

<400>  230
atgctgaacg agggctggaa ggccagcgtg cagcgcaagc tgaagggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaccaacac ccagaacaac      240

gactggttca gcaagctggc cagcagcgcc ttcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgcaacggc      360

cacaccacca gcaccaccca gagcagcgtg ggcgtgacct tcggctacgc caccgccgag      420

gacagcacca gcggccccaa caccagcggc ctggagaccc gcgtgcacca ggccgagcgc      480

ttcttcaaga tggccctgtt cgactgggtg cccagccaga acttcggcca catgcacaag      540

gtggtgctgc cccacgagcc caagggcgtg tacggcggcc tggtgaagag ctacgcctac      600

atgcgcaacg gctgggacgt ggaggtgacc gccgtgggca accagttcaa cggcggctgc      660

ctgctggtgg ccctggtgcc cgagatgggc gacatcagcg accgcgagaa gtaccagctg      720

accctgtacc cccaccagtt catcaacccc cgcaccaaca tgaccgccca catcaccgtg      780

ccctacgtgg gcgtgaaccg ctacgaccag tacaagcagc accgcccctg gaccctggtg      840

gtgatggtgg tggcccccct gaccaccaac accgccggcg cccagcagat caaggtgtac      900

gccaacatcg cccccaccaa cgtgcacgtg gccggcgagc tgcccagcaa ggagggcatc      960

ttccccgtgg cctgcagcga cggctacggc aacatggtga ccaccgaccc caagaccgcc     1020

gaccccgtgt acggcaaggt gtacaacccc ccccgcaccg ccctgcccgg ccgcttcacc     1080

aactacctgg acgtggccga ggcctgcccc accttcctga tgttcgagaa cgtgccctac     1140

gtgagcaccc gcaccgacgg ccagcgcctg ctggccaagt tcgacgtgag cctggccgcc     1200

aagcacatga gcaacaccta cctggccggc ctggcccagt actacaccca gtacaccggc     1260

accatcaacc tgcacttcat gttcaccggc cccaccgacg ccaaggcccg ctacatggtg     1320

gcctacgtgc cccccggcat ggacgccccc gacaaccccg aggaggccgc ccactgcatc     1380

cacgccgagt gggacaccgg cctgaacagc aagttcacct tcagcatccc ctacatcagc     1440

gccgccgact acgcctacac cgccagccac aaggccgaga ccacctgcgt gcagggctgg     1500

gtgtgcgtgt accagatcac ccacggcaag gccgacgccg acgccctggt ggtgagcgcc     1560

agcgccggca aggacttcga gctgcgcctg cccgtggacg cccgcaagca gaccaccacc     1620

accggcgaga gcgccgaccc cgtgaccacc accgtggaga actacggcgg cgagacccag     1680

gtgcagcgcc gccaccacac cgacgtggcc ttcgtgctgg accgcttcgt ggaggtgacc     1740

gtgagcggcc gcaaccagca caccctggac gtgatgcagg cccacaagga caacatcgtg     1800

ggcgccctgc tgcgcgccgc cacctactac ttcagcgacc tggagatcgc cgtgacccac     1860

accggcaagc tgacctgggt gcccaacggc gcccccgtga gcgccctgaa caacaccacc     1920

aaccccaccg cctaccacaa gggccccgtg acccgcctgg ccctgcccta caccgccccc     1980

caccgcgtgc tggccaccgc ctacaccggc accaccacct acaccgccag cgcccgcggc     2040

gacctggccc acctgaccac cacccacgcc cgccacctgc ccaccagctt caacttcggc     2100

gccgtgaagg ccgagaccat caccgagctg ctggtgcgca tgaagcgcgc cgagctg        2157


<210>  231
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype C amino acid

<400>  231

Met Leu Asn Glu Gly Trp Lys Ala Ser Val Gln Arg Lys Leu Lys Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Phe Gly Tyr Ala Thr Ala Glu Asp Ser Thr Ser 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val His Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Met Ala Leu Phe Asp Trp Val Pro Ser Gln Asn Phe Gly 
                165                 170                 175     


His Met His Lys Val Val Leu Pro His Glu Pro Lys Gly Val Tyr Gly 
            180                 185                 190         


Gly Leu Val Lys Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu 
        195                 200                 205             


Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Leu Val Pro Glu Met Gly Asp Ile Ser Asp Arg Glu Lys Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Tyr Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala 
                245                 250                 255     


His Ile Thr Val Pro Tyr Val Gly Val Asn Arg Tyr Asp Gln Tyr Lys 
            260                 265                 270         


Gln His Arg Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr 
        275                 280                 285             


Thr Asn Thr Ala Gly Ala Gln Gln Ile Lys Val Tyr Ala Asn Ile Ala 
    290                 295                 300                 


Pro Thr Asn Val His Val Ala Gly Glu Leu Pro Ser Lys Glu Gly Ile 
305                 310                 315                 320 


Phe Pro Val Ala Cys Ser Asp Gly Tyr Gly Asn Met Val Thr Thr Asp 
                325                 330                 335     


Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Tyr Asn Pro Pro Arg 
            340                 345                 350         


Thr Ala Leu Pro Gly Arg Phe Thr Asn Tyr Leu Asp Val Ala Glu Ala 
        355                 360                 365             


Cys Pro Thr Phe Leu Met Phe Glu Asn Val Pro Tyr Val Ser Thr Arg 
    370                 375                 380                 


Thr Asp Gly Gln Arg Leu Leu Ala Lys Phe Asp Val Ser Leu Ala Ala 
385                 390                 395                 400 


Lys His Met Ser Asn Thr Tyr Leu Ala Gly Leu Ala Gln Tyr Tyr Thr 
                405                 410                 415     


Gln Tyr Thr Gly Thr Ile Asn Leu His Phe Met Phe Thr Gly Pro Thr 
            420                 425                 430         


Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Val Pro Pro Gly Met Asp 
        435                 440                 445             


Ala Pro Asp Asn Pro Glu Glu Ala Ala His Cys Ile His Ala Glu Trp 
    450                 455                 460                 


Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Ile Ser 
465                 470                 475                 480 


Ala Ala Asp Tyr Ala Tyr Thr Ala Ser His Lys Ala Glu Thr Thr Cys 
                485                 490                 495     


Val Gln Gly Trp Val Cys Val Tyr Gln Ile Thr His Gly Lys Ala Asp 
            500                 505                 510         


Ala Asp Ala Leu Val Val Ser Ala Ser Ala Gly Lys Asp Phe Glu Leu 
        515                 520                 525             


Arg Leu Pro Val Asp Ala Arg Lys Gln Thr Thr Thr Thr Gly Glu Ser 
    530                 535                 540                 


Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln 
545                 550                 555                 560 


Val Gln Arg Arg His His Thr Asp Val Ala Phe Val Leu Asp Arg Phe 
                565                 570                 575     


Val Glu Val Thr Val Ser Gly Arg Asn Gln His Thr Leu Asp Val Met 
            580                 585                 590         


Gln Ala His Lys Asp Asn Ile Val Gly Ala Leu Leu Arg Ala Ala Thr 
        595                 600                 605             


Tyr Tyr Phe Ser Asp Leu Glu Ile Ala Val Thr His Thr Gly Lys Leu 
    610                 615                 620                 


Thr Trp Val Pro Asn Gly Ala Pro Val Ser Ala Leu Asn Asn Thr Thr 
625                 630                 635                 640 


Asn Pro Thr Ala Tyr His Lys Gly Pro Val Thr Arg Leu Ala Leu Pro 
                645                 650                 655     


Tyr Thr Ala Pro His Arg Val Leu Ala Thr Ala Tyr Thr Gly Thr Thr 
            660                 665                 670         


Thr Tyr Thr Ala Ser Ala Arg Gly Asp Leu Ala His Leu Thr Thr Thr 
        675                 680                 685             


His Ala Arg His Leu Pro Thr Ser Phe Asn Phe Gly Ala Val Lys Ala 
    690                 695                 700                 


Glu Thr Ile Thr Glu Leu Leu Val Arg Met Lys Arg Ala Glu Leu 
705                 710                 715                 


<210>  232
<211>  2169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype O nucleic acid

<400>  232
atgctgaacg gcgagtggaa ggccaaggtg cagaagcgcc tgcgcggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaccaacac ccagaacaac      240

gactggttca gcaagctggc cagcagcgcc ttcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgcaacggc      360

cacaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacgc caccgccgag      420

gacttcgtga gcggccccaa caccagcggc ctggagaccc gcgtggtgca ggccgagcgc      480

ttcttcaaga cccacctgtt cgactgggtg accagcgacc ccttcggccg ctgctacctg      540

ctggagctgc ccaccgacca caagggcgtg tacggcagcc tgaccgacag ctacgcctac      600

atgcgcaacg gctgggacgt ggaggtgacc gccgtgggca accagttcaa cggcggctgc      660

ctgctggtgg ccatggtgcc cgagctgtgc agcatcgaca agcgcgagct gtaccagctg      720

accctgttcc cccaccagtt catcaacccc cgcaccaaca tgaccgccca catcaccgtg      780

cccttcgtgg gcgtgaaccg ctacgaccag tacaaggtgc acaagccctg gaccctggtg      840

gtgatggtgg tggcccccct gaccgtgaac accgagggcg ccccccagat caaggtgtac      900

gccaacatcg cccccaccaa cgtgcacgtg gccggcgagt tccccagcaa ggagggcatc      960

ttccccgtgg cctgcagcga cggctacggc ggcctggtga ccaccgaccc caagaccgcc     1020

gaccccgcct acggcaaggt gttcaacccc ccccgcaaca tgctgcccgg ccgcttcacc     1080

aacttcctgg acgtggccga ggcctgcccc accttcctgc acttcgaggg cggcgtgccc     1140

tacgtgacca ccaagaccga cagcgaccgc gtgctggccc agttcgacct gagcctggcc     1200

gccaagcaca tgagcaacac cttcctggcc ggcctggccc agtactacac ccagtacagc     1260

ggcaccatca acctgcactt catgttcacc ggccccaccg acgccaaggc ccgctacatg     1320

atcgcctacg ccccccccgg catggagccc cccaagaccc ccgaggccgc cgcccactgc     1380

atccacgccg agtgggacac cggcctgaac agcaagttca ccttcagcat cccctacctg     1440

agcgccgccg actacgccta caccgccagc gacgccgccg agaccaccaa cgtgcagggc     1500

tgggtgtgcc tgttccagat cacccacggc aaggccgacg gcgacgccct ggtggtgctg     1560

gccagcgccg gcaaggactt cgagctgcgc ctgcccgtgg acgcccgcac ccagaccacc     1620

agcgccggcg agagcgccga ccccgtgacc gccaccgtgg agaactacgg cggcgagacc     1680

caggtgcagc gccgccagca caccgacgtg agcttcatcc tggaccgctt cgtgaaggtg     1740

acccccaagg accagatcaa cgtgctggac ctgatgcaga cccccgccca caccctggtg     1800

ggcgccctgc tgcgcaccgc cacctactac ttcgccgacc tggaggtggc cgtgaagcac     1860

gagggcaacc tgacctgggt gcccaacggc gcccccgaga ccgccctgga caacaccacc     1920

aaccccaccg cctaccacaa ggcccccctg acccgcctgg ccctgcccta caccgccccc     1980

caccgcgtgc tggccaccgt gtacaacggc aactgcaagt acggcgagag ccccgtgacc     2040

aacgtgcgcg gcgacctgca ggtgctggcc cagaaggccg cccgcaccct gcccaccagc     2100

ttcaactacg gcgccatcaa ggccacccgc gtgaccgagc tgctgtaccg catgaagcgc     2160

gccgagacc                                                             2169


<210>  233
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VPI-VP4 subtype 0 nucleic acid

<400>  233

Met Leu Asn Gly Glu Trp Lys Ala Lys Val Gln Lys Arg Leu Arg Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Ser Ser Ala Phe Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Ala Thr Ala Glu Asp Phe Val Ser 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Thr His Leu Phe Asp Trp Val Thr Ser Asp Pro Phe Gly 
                165                 170                 175     


Arg Cys Tyr Leu Leu Glu Leu Pro Thr Asp His Lys Gly Val Tyr Gly 
            180                 185                 190         


Ser Leu Thr Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu 
        195                 200                 205             


Val Thr Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Leu Cys Ser Ile Asp Lys Arg Glu Leu Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala 
                245                 250                 255     


His Ile Thr Val Pro Phe Val Gly Val Asn Arg Tyr Asp Gln Tyr Lys 
            260                 265                 270         


Val His Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr 
        275                 280                 285             


Val Asn Thr Glu Gly Ala Pro Gln Ile Lys Val Tyr Ala Asn Ile Ala 
    290                 295                 300                 


Pro Thr Asn Val His Val Ala Gly Glu Phe Pro Ser Lys Glu Gly Ile 
305                 310                 315                 320 


Phe Pro Val Ala Cys Ser Asp Gly Tyr Gly Gly Leu Val Thr Thr Asp 
                325                 330                 335     


Pro Lys Thr Ala Asp Pro Ala Tyr Gly Lys Val Phe Asn Pro Pro Arg 
            340                 345                 350         


Asn Met Leu Pro Gly Arg Phe Thr Asn Phe Leu Asp Val Ala Glu Ala 
        355                 360                 365             


Cys Pro Thr Phe Leu His Phe Glu Gly Gly Val Pro Tyr Val Thr Thr 
    370                 375                 380                 


Lys Thr Asp Ser Asp Arg Val Leu Ala Gln Phe Asp Leu Ser Leu Ala 
385                 390                 395                 400 


Ala Lys His Met Ser Asn Thr Phe Leu Ala Gly Leu Ala Gln Tyr Tyr 
                405                 410                 415     


Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr Gly Pro 
            420                 425                 430         


Thr Asp Ala Lys Ala Arg Tyr Met Ile Ala Tyr Ala Pro Pro Gly Met 
        435                 440                 445             


Glu Pro Pro Lys Thr Pro Glu Ala Ala Ala His Cys Ile His Ala Glu 
    450                 455                 460                 


Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro Tyr Leu 
465                 470                 475                 480 


Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Ala Ala Glu Thr Thr 
                485                 490                 495     


Asn Val Gln Gly Trp Val Cys Leu Phe Gln Ile Thr His Gly Lys Ala 
            500                 505                 510         


Asp Gly Asp Ala Leu Val Val Leu Ala Ser Ala Gly Lys Asp Phe Glu 
        515                 520                 525             


Leu Arg Leu Pro Val Asp Ala Arg Thr Gln Thr Thr Ser Ala Gly Glu 
    530                 535                 540                 


Ser Ala Asp Pro Val Thr Ala Thr Val Glu Asn Tyr Gly Gly Glu Thr 
545                 550                 555                 560 


Gln Val Gln Arg Arg Gln His Thr Asp Val Ser Phe Ile Leu Asp Arg 
                565                 570                 575     


Phe Val Lys Val Thr Pro Lys Asp Gln Ile Asn Val Leu Asp Leu Met 
            580                 585                 590         


Gln Thr Pro Ala His Thr Leu Val Gly Ala Leu Leu Arg Thr Ala Thr 
        595                 600                 605             


Tyr Tyr Phe Ala Asp Leu Glu Val Ala Val Lys His Glu Gly Asn Leu 
    610                 615                 620                 


Thr Trp Val Pro Asn Gly Ala Pro Glu Thr Ala Leu Asp Asn Thr Thr 
625                 630                 635                 640 


Asn Pro Thr Ala Tyr His Lys Ala Pro Leu Thr Arg Leu Ala Leu Pro 
                645                 650                 655     


Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr Asn Gly Asn Cys 
            660                 665                 670         


Lys Tyr Gly Glu Ser Pro Val Thr Asn Val Arg Gly Asp Leu Gln Val 
        675                 680                 685             


Leu Ala Gln Lys Ala Ala Arg Thr Leu Pro Thr Ser Phe Asn Tyr Gly 
    690                 695                 700                 


Ala Ile Lys Ala Thr Arg Val Thr Glu Leu Leu Tyr Arg Met Lys Arg 
705                 710                 715                 720 


Ala Glu Thr 
            


<210>  234
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT1 nucleic acid

<400>  234
atgctggacg tggactggca ggaccgcgcc ggcctgttcc tgcgcggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaacaacac ccagaacaac      240

gactggttca gcaagctggc ccagagcgcc ttcagcggcc tggtgggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcatgaccac cagccacggc      360

accaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacgc cctggccgac      420

aagttcctgc ccggccccaa caccaacggc ctggagaccc gcgtggagca ggccgagcgc      480

ttcttcaagc acaagctgtt cgactggacc accgaccagc agttcggcac cacccacgtg      540

ctggagctgc ccaccgacca caagggcatc tacggccagc tggtggacag ccacgcctac      600

atccgcaacg gctgggacgt gcaggtgagc gccaccgcca cccagttcaa cggcggctgc      660

ctgctggtgg ccatggtgcc cgagctgtgc aagctggacg accgcgagaa gtaccagctg      720

accctgttcc cccaccagtt cctgaacccc cgcaccaaca ccaccgccca catccaggtg      780

ccctacctgg gcgtggaccg ccacgaccag ggcacccgcc acaaggcctg gaccctggtg      840

gtgatggtgg tggcccccta caccaacgac cagaccatcg gcagcaccaa ggccgaggtg      900

tacgtgaaca tcgcccccac caacgtgtac gtggccggcg agaagcccgc caagcagggc      960

atcctgcccg tggccgtgag cgacggctac ggcggcttcc agaacaccga ccccaagacc     1020

agcgacccca tctacggcca cgtgtacaac cccgcccgca ccctgtaccc cggccgcttc     1080

accaacctgc tggacgtggc cgaggcctgc cccaccctgc tggacttcaa cggcgtgccc     1140

tacgtgcaga cccagaacaa cagcggcagc aaggtgctgg cccgcttcga cctggccttc     1200

ggccacaaga acatgaagaa cacctacatg agcggcctgg cccagtactt cgcccagtac     1260

agcggcaccc tgaacctgca cttcatgtac accggcccca ccaacaacaa ggccaagtac     1320

atggtggcct acatcccccc cggcacccac cccctgcccg agacccccga gatggccagc     1380

cactgctacc acgccgagtg ggacaccggc ctgaacagca ccttcacctt caccgtgccc     1440

tacatcagcg ccgccgacta cgcctacacc tacgccgacg agcccgagca ggccagcgtg     1500

cagggctggg tgggcgtgta ccagatcacc gacacccacg agaaggacgg cgccgtgatc     1560

gtgaccgtga gcgccggccc cgacttcgag ttccgcatgc ccatcagccc cagccgccag     1620

accaccagcg ccggcgaggg cgccgacccc gtgaccaccg acgtgagcga gcacggcggc     1680

gacagccgca ccgcccgccg cgcccacacc gacgtggcct tcctgctgga ccgcttcacc     1740

ctggtgggca agacccagga caacaagctg gtgctggacc tgctgaccac caaggagaag     1800

agcctggtgg gcgccctgct gcgcgccgcc acctactact tcagcgacct ggaggtggcc     1860

tgcgtgggca ccaacaagtg ggtgggctgg acccccaacg gcagccccgt gaagctgagc     1920

gaggtgggcg acaaccccgt ggtgttcagc cacaacggca ccacccgctt cgccctgccc     1980

tacaccgccc cccaccgcgt gctggccacc gtgtacaacg gcgactgcaa gtacaagccc     2040

accggcaccc ccccccgcga gaacatccgc ggcgacctgg ccaccctggc cgcccgcatc     2100

gccagcgaga cccacatccc caccaccttc aactacggca tgatctacac cgaggccgag     2160

gtggacgtgt acctgcgcat gaagcgcgcc gagctg                               2196


<210>  235
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT1 amino acid

<400>  235

Met Leu Asp Val Asp Trp Gln Asp Arg Ala Gly Leu Phe Leu Arg Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Gln Ser Ala Phe Ser Gly Leu Val Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Met Thr Thr Ser His Gly Thr Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Ala Leu Ala Asp Lys Phe Leu Pro 
    130                 135                 140                 


Gly Pro Asn Thr Asn Gly Leu Glu Thr Arg Val Glu Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys His Lys Leu Phe Asp Trp Thr Thr Asp Gln Gln Phe Gly 
                165                 170                 175     


Thr Thr His Val Leu Glu Leu Pro Thr Asp His Lys Gly Ile Tyr Gly 
            180                 185                 190         


Gln Leu Val Asp Ser His Ala Tyr Ile Arg Asn Gly Trp Asp Val Gln 
        195                 200                 205             


Val Ser Ala Thr Ala Thr Gln Phe Asn Gly Gly Cys Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Leu Cys Lys Leu Asp Asp Arg Glu Lys Tyr Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Leu Asn Pro Arg Thr Asn Thr Thr Ala 
                245                 250                 255     


His Ile Gln Val Pro Tyr Leu Gly Val Asp Arg His Asp Gln Gly Thr 
            260                 265                 270         


Arg His Lys Ala Trp Thr Leu Val Val Met Val Val Ala Pro Tyr Thr 
        275                 280                 285             


Asn Asp Gln Thr Ile Gly Ser Thr Lys Ala Glu Val Tyr Val Asn Ile 
    290                 295                 300                 


Ala Pro Thr Asn Val Tyr Val Ala Gly Glu Lys Pro Ala Lys Gln Gly 
305                 310                 315                 320 


Ile Leu Pro Val Ala Val Ser Asp Gly Tyr Gly Gly Phe Gln Asn Thr 
                325                 330                 335     


Asp Pro Lys Thr Ser Asp Pro Ile Tyr Gly His Val Tyr Asn Pro Ala 
            340                 345                 350         


Arg Thr Leu Tyr Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala Glu 
        355                 360                 365             


Ala Cys Pro Thr Leu Leu Asp Phe Asn Gly Val Pro Tyr Val Gln Thr 
    370                 375                 380                 


Gln Asn Asn Ser Gly Ser Lys Val Leu Ala Arg Phe Asp Leu Ala Phe 
385                 390                 395                 400 


Gly His Lys Asn Met Lys Asn Thr Tyr Met Ser Gly Leu Ala Gln Tyr 
                405                 410                 415     


Phe Ala Gln Tyr Ser Gly Thr Leu Asn Leu His Phe Met Tyr Thr Gly 
            420                 425                 430         


Pro Thr Asn Asn Lys Ala Lys Tyr Met Val Ala Tyr Ile Pro Pro Gly 
        435                 440                 445             


Thr His Pro Leu Pro Glu Thr Pro Glu Met Ala Ser His Cys Tyr His 
    450                 455                 460                 


Ala Glu Trp Asp Thr Gly Leu Asn Ser Thr Phe Thr Phe Thr Val Pro 
465                 470                 475                 480 


Tyr Ile Ser Ala Ala Asp Tyr Ala Tyr Thr Tyr Ala Asp Glu Pro Glu 
                485                 490                 495     


Gln Ala Ser Val Gln Gly Trp Val Gly Val Tyr Gln Ile Thr Asp Thr 
            500                 505                 510         


His Glu Lys Asp Gly Ala Val Ile Val Thr Val Ser Ala Gly Pro Asp 
        515                 520                 525             


Phe Glu Phe Arg Met Pro Ile Ser Pro Ser Arg Gln Thr Thr Ser Ala 
    530                 535                 540                 


Gly Glu Gly Ala Asp Pro Val Thr Thr Asp Val Ser Glu His Gly Gly 
545                 550                 555                 560 


Asp Ser Arg Thr Ala Arg Arg Ala His Thr Asp Val Ala Phe Leu Leu 
                565                 570                 575     


Asp Arg Phe Thr Leu Val Gly Lys Thr Gln Asp Asn Lys Leu Val Leu 
            580                 585                 590         


Asp Leu Leu Thr Thr Lys Glu Lys Ser Leu Val Gly Ala Leu Leu Arg 
        595                 600                 605             


Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Val Ala Cys Val Gly Thr 
    610                 615                 620                 


Asn Lys Trp Val Gly Trp Thr Pro Asn Gly Ser Pro Val Lys Leu Ser 
625                 630                 635                 640 


Glu Val Gly Asp Asn Pro Val Val Phe Ser His Asn Gly Thr Thr Arg 
                645                 650                 655     


Phe Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Val Tyr 
            660                 665                 670         


Asn Gly Asp Cys Lys Tyr Lys Pro Thr Gly Thr Pro Pro Arg Glu Asn 
        675                 680                 685             


Ile Arg Gly Asp Leu Ala Thr Leu Ala Ala Arg Ile Ala Ser Glu Thr 
    690                 695                 700                 


His Ile Pro Thr Thr Phe Asn Tyr Gly Met Ile Tyr Thr Glu Ala Glu 
705                 710                 715                 720 


Val Asp Val Tyr Leu Arg Met Lys Arg Ala Glu Leu 
                725                 730         


<210>  236
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT2 nucleic acid

<400>  236
atgctggacg tggactggca ggacaaggcc ggcctgttcc tgcgcggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaacaacac ccagaacaac      240

gactggttca gcaagctggc ccagagcgcc atcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac caccctgctg gaggaccgca tcctgaccac ccgccacggc      360

accaccacca gcaccaccca gagcagcgtg ggcatcacct acggctacgc cgacgccgac      420

agcttccgcc ccggccccaa caccagcggc ctggagaccc gcgtggagca ggccgagcgc      480

ttcttcaagg agaagctgtt cgactggacc agcgacaagc ccttcggcac cctgtacgtg      540

ctggagctgc ccaaggacca caagggcatc tacggcagcc tgaccgacgc ctacacctac      600

atgcgcaacg gctgggacgt gcaggtgagc gccaccagca cccagttcaa cggcggcagc      660

ctgctggtgg ccatggtgcc cgagctgtgc agcctgaagg accgcgagga gttccagctg      720

accctgtacc cccaccagtt catcaacccc cgcaccaaca ccaccgccca catccaggtg      780

ccctacctgg gcgtgaaccg ccacgaccag ggcaagcgcc accaggcctg gagcctggtg      840

gtgatggtgc tgacccccct gaccaccgag gcccagatga acagcggcac cgtggaggtg      900

tacgccaaca tcgcccccac caacgtgttc gtggccggcg agaagcccgc caagcagggc      960

atcatccccg tggcctgcgc cgacggctac ggcggcttcc agaacaccga ccccaagacc     1020

gccgacccca tctacggcta cgtgtacaac cccagccgca acgactgcca cggccgctac     1080

agcaacctgc tggacgtggc cgaggcctgc cccaccctgc tgaacttcga cggcaagccc     1140

tacgtggtga ccaagaacaa cggcgacaag gtgatggccg ccttcgacgt ggccttcacc     1200

cacaaggtgc acaagaacac cttcctggcc ggcctggccg actactacac ccagtaccag     1260

ggcagcctga actaccactt catgtacacc ggccccaccc accacaaggc caagttcatg     1320

gtggcctaca tcccccccgg catcgagacc gacaagctgc ccaagacccc cgaggacgcc     1380

gcccactgct accacagcga gtgggacacc ggcctgaaca gccagttcac cttcgccgtg     1440

ccctacgtga gcgccagcga cttcagctac acccacaccg acacccccgc catggccacc     1500

accaacggct gggtggccgt gttccaggtg accgacaccc acagcgccga ggccgccgtg     1560

gtggtgagcg tgagcgccgg ccccgacctg gagttccgct tccccatcga ccccgtgcgc     1620

cagaccacca gcgccggcga gggcgccgag gtggtgacca ccgaccccag cacccacggc     1680

ggcaaggtga ccgagaagcg ccgcgtgcac accgacgtgg ccttcgtgct ggaccgcttc     1740

acccacgtgc acaccaacaa gaccaccttc gccgtggacc tgatggacac caaggagaag     1800

accctggtgg gcgccctgct gcgcgccgcc acctactact tctgcgacct ggagatcgcc     1860

tgcgtgggcg agcacaagcg cgtgttctgg cagcccaacg gcgccccccg caccacccag     1920

ctgggcgaca accccatggt gttcagccac aacaaggtga cccgcttcgc catcccctac     1980

accgcccccc accgcctgct gagcaccgtg tacaacggcg agtgcgagta caccaagacc     2040

gtgaccgcca tccgcggcga ccgcgaggtg ctggccgcca agtacagcag cgccaagcac     2100

accctgccca gcaccttcaa cttcggcttc gtgaccgccg acgagcccgt ggacgtgtac     2160

taccgcatga agcgcgccga gctg                                            2184


<210>  237
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT2 amino acid

<400>  237

Met Leu Asp Val Asp Trp Gln Asp Lys Ala Gly Leu Phe Leu Arg Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Gln Ser Ala Ile Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg His Gly Thr Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Ile Thr Tyr Gly Tyr Ala Asp Ala Asp Ser Phe Arg Pro 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Thr Arg Val Glu Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Glu Lys Leu Phe Asp Trp Thr Ser Asp Lys Pro Phe Gly 
                165                 170                 175     


Thr Leu Tyr Val Leu Glu Leu Pro Lys Asp His Lys Gly Ile Tyr Gly 
            180                 185                 190         


Ser Leu Thr Asp Ala Tyr Thr Tyr Met Arg Asn Gly Trp Asp Val Gln 
        195                 200                 205             


Val Ser Ala Thr Ser Thr Gln Phe Asn Gly Gly Ser Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Leu Cys Ser Leu Lys Asp Arg Glu Glu Phe Gln Leu 
225                 230                 235                 240 


Thr Leu Tyr Pro His Gln Phe Ile Asn Pro Arg Thr Asn Thr Thr Ala 
                245                 250                 255     


His Ile Gln Val Pro Tyr Leu Gly Val Asn Arg His Asp Gln Gly Lys 
            260                 265                 270         


Arg His Gln Ala Trp Ser Leu Val Val Met Val Leu Thr Pro Leu Thr 
        275                 280                 285             


Thr Glu Ala Gln Met Asn Ser Gly Thr Val Glu Val Tyr Ala Asn Ile 
    290                 295                 300                 


Ala Pro Thr Asn Val Phe Val Ala Gly Glu Lys Pro Ala Lys Gln Gly 
305                 310                 315                 320 


Ile Ile Pro Val Ala Cys Ala Asp Gly Tyr Gly Gly Phe Gln Asn Thr 
                325                 330                 335     


Asp Pro Lys Thr Ala Asp Pro Ile Tyr Gly Tyr Val Tyr Asn Pro Ser 
            340                 345                 350         


Arg Asn Asp Cys His Gly Arg Tyr Ser Asn Leu Leu Asp Val Ala Glu 
        355                 360                 365             


Ala Cys Pro Thr Leu Leu Asn Phe Asp Gly Lys Pro Tyr Val Val Thr 
    370                 375                 380                 


Lys Asn Asn Gly Asp Lys Val Met Ala Ala Phe Asp Val Ala Phe Thr 
385                 390                 395                 400 


His Lys Val His Lys Asn Thr Phe Leu Ala Gly Leu Ala Asp Tyr Tyr 
                405                 410                 415     


Thr Gln Tyr Gln Gly Ser Leu Asn Tyr His Phe Met Tyr Thr Gly Pro 
            420                 425                 430         


Thr His His Lys Ala Lys Phe Met Val Ala Tyr Ile Pro Pro Gly Ile 
        435                 440                 445             


Glu Thr Asp Lys Leu Pro Lys Thr Pro Glu Asp Ala Ala His Cys Tyr 
    450                 455                 460                 


His Ser Glu Trp Asp Thr Gly Leu Asn Ser Gln Phe Thr Phe Ala Val 
465                 470                 475                 480 


Pro Tyr Val Ser Ala Ser Asp Phe Ser Tyr Thr His Thr Asp Thr Pro 
                485                 490                 495     


Ala Met Ala Thr Thr Asn Gly Trp Val Ala Val Phe Gln Val Thr Asp 
            500                 505                 510         


Thr His Ser Ala Glu Ala Ala Val Val Val Ser Val Ser Ala Gly Pro 
        515                 520                 525             


Asp Leu Glu Phe Arg Phe Pro Ile Asp Pro Val Arg Gln Thr Thr Ser 
    530                 535                 540                 


Ala Gly Glu Gly Ala Glu Val Val Thr Thr Asp Pro Ser Thr His Gly 
545                 550                 555                 560 


Gly Lys Val Thr Glu Lys Arg Arg Val His Thr Asp Val Ala Phe Val 
                565                 570                 575     


Leu Asp Arg Phe Thr His Val His Thr Asn Lys Thr Thr Phe Ala Val 
            580                 585                 590         


Asp Leu Met Asp Thr Lys Glu Lys Thr Leu Val Gly Ala Leu Leu Arg 
        595                 600                 605             


Ala Ala Thr Tyr Tyr Phe Cys Asp Leu Glu Ile Ala Cys Val Gly Glu 
    610                 615                 620                 


His Lys Arg Val Phe Trp Gln Pro Asn Gly Ala Pro Arg Thr Thr Gln 
625                 630                 635                 640 


Leu Gly Asp Asn Pro Met Val Phe Ser His Asn Lys Val Thr Arg Phe 
                645                 650                 655     


Ala Ile Pro Tyr Thr Ala Pro His Arg Leu Leu Ser Thr Val Tyr Asn 
            660                 665                 670         


Gly Glu Cys Glu Tyr Thr Lys Thr Val Thr Ala Ile Arg Gly Asp Arg 
        675                 680                 685             


Glu Val Leu Ala Ala Lys Tyr Ser Ser Ala Lys His Thr Leu Pro Ser 
    690                 695                 700                 


Thr Phe Asn Phe Gly Phe Val Thr Ala Asp Glu Pro Val Asp Val Tyr 
705                 710                 715                 720 


Tyr Arg Met Lys Arg Ala Glu Leu 
                725             


<210>  238
<211>  2181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT3 nucleic acid

<400>  238
atgctggacg tggactggca ggaccgcgcc ggcctgttcc tgcgcggcgc cggccagagc       60

agccccgcca ccggcagcca gaaccagagc ggcaacaccg gcagcatcat caacaactac      120

tacatgcagc agtaccagaa cagcatggac acccagctgg gcgacaacgc catcagcggc      180

ggcagcaacg agggcagcac cgacaccacc agcacccaca ccaacaacac ccagaacaac      240

gactggttca gcaagctggc ccagagcgcc atcagcggcc tgttcggcgc cctgctggcc      300

gacaagaaga ccgaggagac cacccacctg gaggaccgca tcctgaccac ccgccacaac      360

accaccacca gcaccaccca gagcagcgtg ggcgtgacct acggctacgt gagcgccgac      420

cgcttcctgc ccggccccaa caccagcggc ctggagagcc gcgtggagca ggccgagcgc      480

ttcttcaagg agaagctgtt cacctggacc gccagccagg agtacgccca cgtgcacctg      540

ctggagctgc ccaccgacca caagggcatc tacggcgcca tggtggacag ccacgcctac      600

gtgcgcaacg gctgggacgt gcaggtgacc gccaccagca cccagttcaa cggcggcacc      660

ctgctggtgg ccatggtgcc cgagctgcac agcctggaca cccgcgacgt gagccagctg      720

accctgttcc cccaccagtt catcaacccc cgcaccaaca ccaccgccca catcgtggtg      780

ccctacgtgg gcgtgaaccg ccacgaccag gtgcagatgc acaaggcctg gaccctggtg      840

gtggccgtga tggcccccct gaccaccagc agcatgggcc aggacaacgt ggaggtgtac      900

gccaacatcg cccccaccaa cgtgtacgtg gccggcgagc gccccagcaa gcagggcatc      960

atccccgtgg cctgcaacga cggctacggc ggcttccaga acaccgaccc caagaccgcc     1020

gaccccatct acggcctggt gagcaacccc ccccgcaccg ccttccccgg ccgcttcacc     1080

aacctgctgg acgtggccga ggcctgcccc accttcctgg acttcgacgg cgtgccctac     1140

gtgaagacca cccacaacag cggcagcaag atcctgaccc acatcgacct ggccttcggc     1200

cacaagagct tcaagaacac ctacctggcc ggcctggccc agtactacgc ccagtacagc     1260

ggcagcatca acctgcactt catgtacacc ggccccaccc agagcaaggc ccgcttcatg     1320

gtggcctaca tcccccccgg caccaccgtg cccaacaccc ccgagcaggc cgcccactgc     1380

taccacagcg agtgggacac cggcctgaac agcaagttca ccttcaccgt gccctacatg     1440

agcgccgccg acttcgccta cacctactgc gacgagcccg agcaggccag cgcccagggc     1500

tgggtgaccc tgtaccagat caccgacacc cacgaccccg acagcgccgt gctggtgagc     1560

gtgagcgccg gcgccgactt cgagctgcgc ctgcccatca accccgccgc ccagaccacc     1620

agcgccggcg agggcgccga cgtggtgacc accgacgtga ccacccacgg cggcgaggtg     1680

agcgtgcccc gccgccagca caccaacgtg gagttcctgc tggaccgctt cacccacatc     1740

ggcaccatca acggccaccg caccatctgc ctgatggaca ccaaggagca caccctggtg     1800

ggcgccatcc tgcgcagcgc cacctactac ttctgcgacc tggaggtggc cgtgctgggc     1860

aacgccaagt acgccgcctg ggtgcccaac ggctgccccc acaccgaccg cgtggaggac     1920

aaccccgtgg tgcacagcaa gggcagcgtg gtgcgcttcg ccctgcccta caccgccccc     1980

cacggcgtgc tggccaccgt gtacaacggc aactgcaagt acagcaccac ccagcgcgtg     2040

gccccccgcc gcggcgacct gggcgtgctg agccagcgcg tggagaacga gaccacccgc     2100

tgcatcccca ccaccttcaa cttcggccgc ctgctgtgcg agagcggcga cgtgtactac     2160

cgcatgaagc gcaccgagct g                                               2181


<210>  239
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus VP1-VP4 subtype SAT3 amino acid


<220>
<221>  misc_feature
<222>  (562)..(562)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (570)..(570)
<223>  Xaa can be any naturally occurring amino acid

<400>  239

Met Leu Asp Val Asp Trp Gln Asp Arg Ala Gly Leu Phe Leu Arg Gly 
1               5                   10                  15      


Ala Gly Gln Ser Ser Pro Ala Thr Gly Ser Gln Asn Gln Ser Gly Asn 
            20                  25                  30          


Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn Ser 
        35                  40                  45              


Met Asp Thr Gln Leu Gly Asp Asn Ala Ile Ser Gly Gly Ser Asn Glu 
    50                  55                  60                  


Gly Ser Thr Asp Thr Thr Ser Thr His Thr Asn Asn Thr Gln Asn Asn 
65                  70                  75                  80  


Asp Trp Phe Ser Lys Leu Ala Gln Ser Ala Ile Ser Gly Leu Phe Gly 
                85                  90                  95      


Ala Leu Leu Ala Asp Lys Lys Thr Glu Glu Thr Thr His Leu Glu Asp 
            100                 105                 110         


Arg Ile Leu Thr Thr Arg His Asn Thr Thr Thr Ser Thr Thr Gln Ser 
        115                 120                 125             


Ser Val Gly Val Thr Tyr Gly Tyr Val Ser Ala Asp Arg Phe Leu Pro 
    130                 135                 140                 


Gly Pro Asn Thr Ser Gly Leu Glu Ser Arg Val Glu Gln Ala Glu Arg 
145                 150                 155                 160 


Phe Phe Lys Glu Lys Leu Phe Thr Trp Thr Ala Ser Gln Glu Tyr Ala 
                165                 170                 175     


His Val His Leu Leu Glu Leu Pro Thr Asp His Lys Gly Ile Tyr Gly 
            180                 185                 190         


Ala Met Val Asp Ser His Ala Tyr Val Arg Asn Gly Trp Asp Val Gln 
        195                 200                 205             


Val Thr Ala Thr Ser Thr Gln Phe Asn Gly Gly Thr Leu Leu Val Ala 
    210                 215                 220                 


Met Val Pro Glu Leu His Ser Leu Asp Thr Arg Asp Val Ser Gln Leu 
225                 230                 235                 240 


Thr Leu Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Thr Thr Ala 
                245                 250                 255     


His Ile Val Val Pro Tyr Val Gly Val Asn Arg His Asp Gln Val Gln 
            260                 265                 270         


Met His Lys Ala Trp Thr Leu Val Val Ala Val Met Ala Pro Leu Thr 
        275                 280                 285             


Thr Ser Ser Met Gly Gln Asp Asn Val Glu Val Tyr Ala Asn Ile Ala 
    290                 295                 300                 


Pro Thr Asn Val Tyr Val Ala Gly Glu Arg Pro Ser Lys Gln Gly Ile 
305                 310                 315                 320 


Ile Pro Val Ala Cys Asn Asp Gly Tyr Gly Gly Phe Gln Asn Thr Asp 
                325                 330                 335     


Pro Lys Thr Ala Asp Pro Ile Tyr Gly Leu Val Ser Asn Pro Pro Arg 
            340                 345                 350         


Thr Ala Phe Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala Glu Ala 
        355                 360                 365             


Cys Pro Thr Phe Leu Asp Phe Asp Gly Val Pro Tyr Val Lys Thr Thr 
    370                 375                 380                 


His Asn Ser Gly Ser Lys Ile Leu Thr His Ile Asp Leu Ala Phe Gly 
385                 390                 395                 400 


His Lys Ser Phe Lys Asn Thr Tyr Leu Ala Gly Leu Ala Gln Tyr Tyr 
                405                 410                 415     


Ala Gln Tyr Ser Gly Ser Ile Asn Leu His Phe Met Tyr Thr Gly Pro 
            420                 425                 430         


Thr Gln Ser Lys Ala Arg Phe Met Val Ala Tyr Ile Pro Pro Gly Thr 
        435                 440                 445             


Thr Val Pro Asn Thr Pro Glu Gln Ala Ala His Cys Tyr His Ser Glu 
    450                 455                 460                 


Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Thr Val Pro Tyr Met 
465                 470                 475                 480 


Ser Ala Ala Asp Phe Ala Tyr Thr Tyr Cys Asp Glu Pro Glu Gln Ala 
                485                 490                 495     


Ser Ala Gln Gly Trp Val Thr Leu Tyr Gln Ile Thr Asp Thr His Asp 
            500                 505                 510         


Pro Asp Ser Ala Val Leu Val Ser Val Ser Ala Gly Ala Asp Phe Glu 
        515                 520                 525             


Leu Arg Leu Pro Ile Asn Pro Ala Ala Gln Thr Thr Ser Ala Gly Glu 
    530                 535                 540                 


Gly Ala Asp Val Val Thr Thr Asp Val Thr Thr His Gly Gly Glu Val 
545                 550                 555                 560 


Ser Xaa Pro Arg Arg Gln His Thr Asn Xaa Glu Phe Leu Leu Asp Arg 
                565                 570                 575     


Phe Thr His Ile Gly Thr Ile Asn Gly His Arg Thr Ile Cys Leu Met 
            580                 585                 590         


Asp Thr Lys Glu His Thr Leu Val Gly Ala Ile Leu Arg Ser Ala Thr 
        595                 600                 605             


Tyr Tyr Phe Cys Asp Leu Glu Val Ala Val Leu Gly Asn Ala Lys Tyr 
    610                 615                 620                 


Ala Ala Trp Val Pro Asn Gly Cys Leu His Thr Asp Arg Val Glu Asp 
625                 630                 635                 640 


Asn Pro Val Val His Ser Lys Gly Ser Val Val Arg Phe Ala Leu Pro 
                645                 650                 655     


Tyr Thr Ala Pro His Gly Val Leu Ala Thr Val Tyr Asn Gly Asn Cys 
            660                 665                 670         


Lys Tyr Ser Thr Thr Gln Arg Val Ala Pro Arg Arg Gly Asp Leu Gly 
        675                 680                 685             


Val Leu Ser Gln Arg Val Glu Asn Glu Thr Thr Arg Cys Ile Pro Thr 
    690                 695                 700                 


Thr Phe Asn Phe Gly Arg Leu Leu Cys Glu Ser Gly Asp Val Tyr Tyr 
705                 710                 715                 720 


Arg Met Lys Arg Thr Glu Leu 
                725         


<210>  240
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP1 Asia  subtype nucleic acid

<400>  240
atggactgga cctggatcct gttcctggtc gccgctgcca ctagggtgca cagcaccacc       60

accaccggcg agagcgccga ccccgtgacc accaccgtgg agaactacgg cggcgagaca      120

cagaccgcca ggcgcctcca caccgacgtg gccttcgtgc tggacagatt cgtgaagctg      180

acccagccca agagcaccca gaccctggac ctgatgcaga tccccagcca caccctcgtg      240

ggcgccctgc tgagaagcgc cacctactac ttcagcgacc tggaagtggc cctggtgcac      300

accggccctg tgacctgggt gcccaacggc gctcccaaga ccgccctgaa caaccacacc      360

aaccccaccg cctaccagaa gcagcccatc accaggctgg ccctgcccta caccgcccct      420

cacagggtgc tgtccaccgt gtacaacggc aagaccacct acggcgagga aagcagcaga      480

aggggcgatc tggccgctct cgccaggcgc gtgaacaaca ggctgcccac ctccttcaac      540

tatggcgccg tcaaggccga caccatcacc gagctgctga tcaggatgaa gagggccgag      600

acatactgcc ccaggcccct gctggccctg gacaccaccc aggacaggcg caagcaggaa      660

atcattgccc ccgagaag                                                    678


<210>  241
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 Asia  subtype amino acid

<400>  241

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Thr Thr Thr Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr 
            20                  25                  30          


Val Glu Asn Tyr Gly Gly Glu Thr Gln Thr Ala Arg Arg Leu His Thr 
        35                  40                  45              


Asp Val Ala Phe Val Leu Asp Arg Phe Val Lys Leu Thr Gln Pro Lys 
    50                  55                  60                  


Ser Thr Gln Thr Leu Asp Leu Met Gln Ile Pro Ser His Thr Leu Val 
65                  70                  75                  80  


Gly Ala Leu Leu Arg Ser Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Val 
                85                  90                  95      


Ala Leu Val His Thr Gly Pro Val Thr Trp Val Pro Asn Gly Ala Pro 
            100                 105                 110         


Lys Thr Ala Leu Asn Asn His Thr Asn Pro Thr Ala Tyr Gln Lys Gln 
        115                 120                 125             


Pro Ile Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu 
    130                 135                 140                 


Ser Thr Val Tyr Asn Gly Lys Thr Thr Tyr Gly Glu Glu Ser Ser Arg 
145                 150                 155                 160 


Arg Gly Asp Leu Ala Ala Leu Ala Arg Arg Val Asn Asn Arg Leu Pro 
                165                 170                 175     


Thr Ser Phe Asn Tyr Gly Ala Val Lys Ala Asp Thr Ile Thr Glu Leu 
            180                 185                 190         


Leu Ile Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro Arg Pro Leu Leu 
        195                 200                 205             


Ala Leu Asp Thr Thr Gln Asp Arg Arg Lys Gln Glu Ile Ile Ala Pro 
    210                 215                 220                 


Glu Lys Gln Thr Leu 
225                 


<210>  242
<211>  742
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP1 O  subtype nucleic acid

<400>  242
atggactgga cctggatcct gttcctggtc gccgctgcca ctagggtgca cagcaccacc       60

tctaccgggg agtccgccga tcctgtgaca gccacagtgg aaaattacgg cggggaaacc      120

caggtgcaga ggcggcagca caccgatgtg tctttcatcc tggaccgctt cgtgaaagtg      180

acccccaagg ccgaccagat caacgtgctg gatctcatgc agattcccgc ccatacactc      240

gtcggggctc tgctgcgcac cgccacatac tatttcgccg atctcgaggt ggccgtgaag      300

cacgagggca acctgacatg ggtgccaaat ggcgcccctg aggccgctct ggacaacacc      360

accaatccta cagcctacca caaggccccc ctgaccagac tggctctgcc ttatacagcc      420

ccccaccgcg tgctggccac agtgtataat ggcaactgca agtacggcga agtggccgtc      480

accaacgtgc gcggcgacct ccaggtgctg gcccagaagg ccgccaggac cctgcctacc      540

agctttaact acggggccat caaggccacc agagtgaccg aactgctgta cagaatgaag      600

cgcgccgaaa cctactgccc tagacctctg ctcgccatcc accccagcga ggccaggcac      660

aagcagaaaa ttgtggcccc tgtgaagcag ctgctgtgat gactgcagat atccagcaca      720

gtggcggccg ctcgagtcta ga                                               742


<210>  243
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 O  subtype amino acid

<400>  243

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Thr Thr Ser Thr Gly Glu Ser Ala Asp Pro Val Thr Ala Thr 
            20                  25                  30          


Val Glu Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg Arg Gln His Thr 
        35                  40                  45              


Asp Val Ser Phe Ile Leu Asp Arg Phe Val Lys Val Thr Pro Lys Ala 
    50                  55                  60                  


Asp Gln Ile Asn Val Leu Asp Leu Met Gln Ile Pro Ala His Thr Leu 
65                  70                  75                  80  


Val Gly Ala Leu Leu Arg Thr Ala Thr Tyr Tyr Phe Ala Asp Leu Glu 
                85                  90                  95      


Val Ala Val Lys His Glu Gly Asn Leu Thr Trp Val Pro Asn Gly Ala 
            100                 105                 110         


Pro Glu Ala Ala Leu Asp Asn Thr Thr Asn Pro Thr Ala Tyr His Lys 
        115                 120                 125             


Ala Pro Leu Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val 
    130                 135                 140                 


Leu Ala Thr Val Tyr Asn Gly Asn Cys Lys Tyr Gly Glu Val Ala Val 
145                 150                 155                 160 


Thr Asn Val Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala Arg 
                165                 170                 175     


Thr Leu Pro Thr Ser Phe Asn Tyr Gly Ala Ile Lys Ala Thr Arg Val 
            180                 185                 190         


Thr Glu Leu Leu Tyr Arg Met Lys Arg 
        195                 200     


<210>  244
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP1 A subtype nucleic acid

<400>  244
atggactgga cctggattct gtttctggtg gccgctgcca caagagtgca ctccaccacc       60

tctgccggcg agtccgccga cccagtgacc accaccgtgg agaactacgg cggcgagaca      120

caggtgcagc gcaggcacca caccgacgtg ggcttcatca tggaccgctt cgtgaagatc      180

ggcaacacct cccccaccca cgtgatcgac ctgatgcaga cccaccagca cggactggtg      240

ggagccctgc tgagagccgc cacctactac ttctccgacc tggaaatcgt ggtgcgccac      300

gacggaaacc tgacatgggt gcccaatggc gccccagagg ccgccctgtc caacaccggc      360

aaccccaccg cctacaacaa ggcccccttc accagactgg ccctgccata caccgcccct      420

cacagggtgc tggccaccgt gtacaacggc accaacaagt actccgccgc ctccggaaga      480

acaagaggcg acctgggcac cgtggccgcc agaatcgccg cccagctgcc cgcctccttc      540

aacttcggcg ccatcaaggc cgacgccatc cacgaactgc tggtgcgcat gaagcgcgcc      600

gagctgtact gcccaagacc cctgctggcc gtggaggtgt cctcccagga ccgccacaag      660

cagaagatca tcgccccagc caagcagctg ctgtacccct acgacgtgcc cgactacgcc      720

tccctgggcg gaccatgatg actcgagtct agagggcccg tttaaacccg c               771


<210>  245
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 A  subtype amino acid

<400>  245

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Thr Thr Ser Ala Gly Glu Ser Ala Asp Pro Val Thr Thr Thr 
            20                  25                  30          


Val Glu Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg Arg His His Thr 
        35                  40                  45              


Asp Val Gly Phe Ile Met Asp Arg Phe Val Lys Ile Gly Asn Thr Ser 
    50                  55                  60                  


Pro Thr His Val Ile Asp Leu Met Gln Thr His Gln His Gly Leu Val 
65                  70                  75                  80  


Gly Ala Leu Leu Arg Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile 
                85                  90                  95      


Val Val Arg His Asp Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro 
            100                 105                 110         


Glu Ala Ala Leu Ser Asn Thr Gly Asn Pro Thr Ala Tyr Asn Lys Ala 
        115                 120                 125             


Pro Phe Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu 
    130                 135                 140                 


Ala Thr Val Tyr Asn Gly Thr Asn Lys Tyr Ser Ala Ala Ser Gly Arg 
145                 150                 155                 160 


Thr Arg Gly Asp Leu Gly Thr Val Ala Ala Arg Ile Ala Ala Gln Leu 
                165                 170                 175     


Pro Ala Ser Phe Asn Phe Gly Ala Ile Lys Ala Asp Ala Ile His Glu 
            180                 185                 190         


Leu Leu Val Arg Met Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Leu 
        195                 200                 205             


Leu Ala Val Glu Val Ser Ser Gln Asp Arg His Lys Gln Lys Ile Ile 
    210                 215                 220                 


Ala Pro Ala Lys Gln Leu Leu 
225                 230     


<210>  246
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP1 C  subtype nucleic acid

<400>  246
atggactgga cctggattct gtttctcgtg gccgctgcca caagagtgca cagcaccacc       60

accaccggcg agtccgccga cccagtgacc accaccgtgg agaactacgg cggcgagaca      120

cagacccagc gcaggcacca cacagacgtg gccttcgtgc tggaccgctt cgtgaaggtg      180

caggtgtccg gcaaccagca caccctggac gtgatgcagg tgcacaagga ctccatcgtg      240

ggcgccctgc tgagagccgc cacctactac ttctccgacc tggaaatcgc cgtgacccac      300

accggaaagc tgacctgggt gcccaatggc gccccagtgt ccgccctgga caacaccacc      360

aaccccaccg cctaccacaa gggcccactg accagactgg ccctgccata caccgcccct      420

cacagagtgc tggccacagc ctacaccggc acaaccgcct actccgcctc cgccagaaga      480

ggcgatctgg cccacctcgc cgctgcccac gccagacacc tgcccaccag cttcaacttc      540

ggcgccgtga aggccgagac aatcaccgag ctgctggtgc gcatgaagcg cgccgagctg      600

tactgcccca gacccgtgct gccagtgcag ccatccggcg acagacacaa gcagcccctg      660

atcgccccag ccaagcagct gctgtacccc tacgacgtgc ccgactacgc ctccctgggc      720

ggaccatgat ga                                                          732


<210>  247
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 C subtype amino acid

<400>  247

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Thr Thr Thr Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr 
            20                  25                  30          


Val Glu Asn Tyr Gly Gly Glu Thr Gln Thr Gln Arg Arg His His Thr 
        35                  40                  45              


Asp Val Ala Phe Val Leu Asp Arg Phe Val Lys Val Gln Val Ser Gly 
    50                  55                  60                  


Asn Gln His Thr Leu Asp Val Met Gln Val His Lys Asp Ser Ile Val 
65                  70                  75                  80  


Gly Ala Leu Leu Arg Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile 
                85                  90                  95      


Ala Val Thr His Thr Gly Lys Leu Thr Trp Val Pro Asn Gly Ala Pro 
            100                 105                 110         


Val Ser Ala Leu Asp Asn Thr Thr Asn Pro Thr Ala Tyr His Lys Gly 
        115                 120                 125             


Pro Leu Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu 
    130                 135                 140                 


Ala Thr Ala Tyr Thr Gly Thr Thr Ala Tyr Ser Ala Ser Ala Arg Arg 
145                 150                 155                 160 


Gly Asp Leu Ala His Leu Ala Ala Ala His Ala Arg His Leu Pro Thr 
                165                 170                 175     


Ser Phe Asn Phe Gly Ala Val Lys Ala Glu Thr Ile Thr Glu Leu Leu 
            180                 185                 190         


Val Arg Met Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Val Leu Pro 
        195                 200                 205             


Val Gln Pro Ser Gly Asp Arg His Lys Gln Pro Leu Ile Ala Pro Ala 
    210                 215                 220                 


Lys Gln Leu Leu 
225             


<210>  248
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP1 A  subtype + VP1 C subtype nucleic acid

<400>  248
atggactgga cctggattct gtttctcgtg gccgctgcta caagagtgca ctccaccacc       60

tctgccggcg agtccgccga cccagtgacc accaccgtgg agaactacgg cggcgagaca      120

caggtgcagc gcaggcacca caccgacgtg ggcttcatca tggaccgctt cgtgaagatc      180

ggcaacacct cccccaccca cgtgatcgac ctgatgcaga cccaccagca cggactggtg      240

ggagccctgc tgagagccgc cacctactac ttctccgacc tggaaatcgt ggtgcgccac      300

gacggaaacc tgacctgggt gcccaatggc gctccagagg ccgccctgtc caacaccggc      360

aaccccaccg cctacaacaa ggcccccttc accagactgg ccctgccata caccgcccct      420

cacagggtgc tggccaccgt gtacaacggc accaacaagt actccgccgc ctccggaaga      480

acaagaggcg acctgggcac cgtggccgcc agaatcgccg cccagctgcc cgcctccttc      540

aacttcggcg ccatcaaggc cgacgccatc cacgaactgc tggtgcgcat gaagcgcgcc      600

gagctgtact gcccaagacc cctgctggcc gtggaggtgt cctcccagga ccgccacaag      660

cagaagatca tcgccccagc caagcagctg ctgcgcggca ggaagagaag atccaccacc      720

accacaggcg aaagcgccga tcccgtgaca acaacagtgg aaaattacgg cggggaaacc      780

cagacccagc ggcgccacca cacagatgtg gccttcgtgc tggacagatt cgtgaaggtg      840

caggtgtccg gcaaccagca caccctggac gtgatgcagg tgcacaagga ctccatcgtg      900

ggcgccctgc tgagggccgc cacctactac tttagcgatc tggaaatcgc cgtgacccac      960

accggcaagc tgacatgggt gccaaatggg gcccctgtgt ctgccctgga caacaccacc     1020

aacccaacag cctaccacaa agggccactg acacgcctgg ccctgcctta cacagcccca     1080

caccgcgtgc tggccacagc ctacaccgga accaccgcct actccgcctc cgccagaaga     1140

ggcgatctgg cccatctggc cgctgcccac gccagacacc tgcccaccag cttcaacttt     1200

ggggccgtga aagccgagac aatcaccgag ctgctggtgc ggatgaagag ggccgaactg     1260

tactgtcctc gccccgtgct gccagtgcag ccatccggcg acagacacaa gcagcccctg     1320

atcgcccctg ccaaacagct gctgtacccc tacgacgtgc ccgactacgc ctccctgggc     1380

ggaccatgat gactcgagtc taga                                            1404


<210>  249
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1 A  subtype + VP1 C subtype amino acid

<400>  249

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Thr Thr Ser Ala Gly Glu Ser Ala Asp Pro Val Thr Thr Thr 
            20                  25                  30          


Val Glu Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg Arg His His Thr 
        35                  40                  45              


Asp Val Gly Phe Ile Met Asp Arg Phe Val Lys Ile Gly Asn Thr Ser 
    50                  55                  60                  


Pro Thr His Val Ile Asp Leu Met Gln Thr His Gln His Gly Leu Val 
65                  70                  75                  80  


Gly Ala Leu Leu Arg Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile 
                85                  90                  95      


Val Val Arg His Asp Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro 
            100                 105                 110         


Glu Ala Ala Leu Ser Asn Thr Gly Asn Pro Thr Ala Tyr Asn Lys Ala 
        115                 120                 125             


Pro Phe Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu 
    130                 135                 140                 


Ala Thr Val Tyr Asn Gly Thr Asn Lys Tyr Ser Ala Ala Ser Gly Arg 
145                 150                 155                 160 


Thr Arg Gly Asp Leu Gly Thr Val Ala Ala Arg Ile Ala Ala Gln Leu 
                165                 170                 175     


Pro Ala Ser Phe Asn Phe Gly Ala Ile Lys Ala Asp Ala Ile His Glu 
            180                 185                 190         


Leu Leu Val Arg Met Lys Arg Ala Glu Leu Tyr Cys Pro Arg Pro Leu 
        195                 200                 205             


Leu Ala Val Glu Val Ser Ser Gln Asp Arg His Lys Gln Lys Ile Ile 
    210                 215                 220                 


Ala Pro Ala Lys Gln Leu Leu Arg Gly Arg Lys Arg Arg Ser Thr Thr 
225                 230                 235                 240 


Ala Thr Gly Glu Ser Ala Asp Pro Val Thr Thr Thr Val Glu Asn Tyr 
                245                 250                 255     


Gly Gly Glu Thr Gln Thr Gln Arg Arg His His Thr Asp Val Ala Phe 
            260                 265                 270         


Val Leu Asp Arg Phe Val Lys Val Gln Val Ser Gly Asn Gln His Thr 
        275                 280                 285             


Leu Asp Val Met Gln Val His Lys Asp Ser Ile Val Gly Ala Leu Leu 
    290                 295                 300                 


Arg Ala Ala Thr Tyr Tyr Phe Ser Asp Leu Glu Ile Ala Val Thr His 
305                 310                 315                 320 


Thr Gly Lys Leu Thr Trp Val Pro Asn Gly Ala Pro Val Ser Ala Leu 
                325                 330                 335     


Asp Asn Thr Thr Asn Pro Thr Ala Tyr His Lys Gly Pro Leu Thr Arg 
            340                 345                 350         


Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr Ala Tyr 
        355                 360                 365             


Thr Gly Thr Thr Ala Tyr Ser Ala Ser Ala Arg Arg Gly Asp Leu Ala 
    370                 375                 380                 


His Leu Ala Ala Ala His Ala Arg His Leu Pro Thr Ser Phe Asn Phe 
385                 390                 395                 400 


Gly Ala Val Lys Ala Glu Thr Ile Thr Glu Leu Leu Val Arg Met Lys 
                405                 410                 415     


Arg Ala Glu Leu Tyr Cys Pro Arg Pro Val Leu Pro Val Gln Pro Ser 
            420                 425                 430         


Gly Asp Arg His Lys Gln Pro Leu Ile Ala Pro Ala Lys Gln Leu Leu 
        435                 440                 445             


