                         SEQUENCE LISTING

<110>  The Sir Mortimer B. Davis - Jewish General Hospital
       LEBLANC, Andrea
 
<120>  TRANSGENIC NON-HUMAN ANIMAL MODEL OF NEURODEGENERATIVE DISEASE

<130>  780/15562.3

<150>  US 61/514,532
<151>  2011-08-03

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1661
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (79)..(960)

<400>  1
ccgagggcgg ggccgggccc gggagcctgt ggcttcagga agaggagggc aaggtgtctg       60

gctgcgcgtt tggctgca atg agc tcg gcc tcg ggg ctc cgc agg ggg cac        111
                    Met Ser Ser Ala Ser Gly Leu Arg Arg Gly His           
                    1               5                   10                

ccg gca ggt ggg gaa gaa aac atg aca gaa aca gat gcc ttc tat aaa        159
Pro Ala Gly Gly Glu Glu Asn Met Thr Glu Thr Asp Ala Phe Tyr Lys           
            15                  20                  25                    

aga gaa atg ttt gat ccg gca gaa aag tac aaa atg gac cac agg agg        207
Arg Glu Met Phe Asp Pro Ala Glu Lys Tyr Lys Met Asp His Arg Arg           
        30                  35                  40                        

aga gga att gct tta atc ttc aat cat gag agg ttc ttt tgg cac tta        255
Arg Gly Ile Ala Leu Ile Phe Asn His Glu Arg Phe Phe Trp His Leu           
    45                  50                  55                            

aca ctg cca gaa agg cgg ggc acc tgc gca gat aga gac aat ctt acc        303
Thr Leu Pro Glu Arg Arg Gly Thr Cys Ala Asp Arg Asp Asn Leu Thr           
60                  65                  70                  75            

cgc agg ttt tca gat cta gga ttt gaa gtg aaa tgc ttt aat gat ctt        351
Arg Arg Phe Ser Asp Leu Gly Phe Glu Val Lys Cys Phe Asn Asp Leu           
                80                  85                  90                

aaa gca gaa gaa cta ctg ctc aaa att cat gag gtg tca act gtt agc        399
Lys Ala Glu Glu Leu Leu Leu Lys Ile His Glu Val Ser Thr Val Ser           
            95                  100                 105                   

cac gca gat gcc gat tgc ttt gtg tgt gtc ttc ctg agc cat ggc gaa        447
His Ala Asp Ala Asp Cys Phe Val Cys Val Phe Leu Ser His Gly Glu           
        110                 115                 120                       

ggc aat cac att tat gca tat gat gct aaa atc gaa att cag aca tta        495
Gly Asn His Ile Tyr Ala Tyr Asp Ala Lys Ile Glu Ile Gln Thr Leu           
    125                 130                 135                           

act ggc ttg ttc aaa gga gac aag tgt cac agc ctg gtt gga aaa ccc        543
Thr Gly Leu Phe Lys Gly Asp Lys Cys His Ser Leu Val Gly Lys Pro           
140                 145                 150                 155           

aag ata ttt atc att cag gca tgt cgg gga aac cag cac gat gtg cca        591
Lys Ile Phe Ile Ile Gln Ala Cys Arg Gly Asn Gln His Asp Val Pro           
                160                 165                 170               

gtc att cct ttg gat gta gta gat aat cag aca gag aag ttg gac acc        639
Val Ile Pro Leu Asp Val Val Asp Asn Gln Thr Glu Lys Leu Asp Thr           
            175                 180                 185                   

aac ata act gag gtg gat gca gcc tcc gtt tac acg ctg cct gct gga        687
Asn Ile Thr Glu Val Asp Ala Ala Ser Val Tyr Thr Leu Pro Ala Gly           
        190                 195                 200                       

gct gac ttc ctc atg tgt tac tct gtt gca gaa gga tat tat tct cac        735
Ala Asp Phe Leu Met Cys Tyr Ser Val Ala Glu Gly Tyr Tyr Ser His           
    205                 210                 215                           

cgg gaa act gtg aac ggc tca tgg tac att caa gat ttg tgt gag atg        783
Arg Glu Thr Val Asn Gly Ser Trp Tyr Ile Gln Asp Leu Cys Glu Met           
220                 225                 230                 235           

ttg gga aaa tat ggc tcc tcc tta gag ttc aca gaa ctc ctc aca ctg        831
Leu Gly Lys Tyr Gly Ser Ser Leu Glu Phe Thr Glu Leu Leu Thr Leu           
                240                 245                 250               

gtg aac agg aaa gtt tct cag cgc cga gtg gac ttt tgc aaa gac cca        879
Val Asn Arg Lys Val Ser Gln Arg Arg Val Asp Phe Cys Lys Asp Pro           
            255                 260                 265                   

agt gca att gga aag aag cag gtt ccc tgt ttt gcc tca atg cta act        927
Ser Ala Ile Gly Lys Lys Gln Val Pro Cys Phe Ala Ser Met Leu Thr           
        270                 275                 280                       

aaa aag ctg cat ttc ttt cca aaa tct aat taa ttaatagagg ctatctaatt      980
Lys Lys Leu His Phe Phe Pro Lys Ser Asn                                   
    285                 290                                               

ttacactctg tattgaaaat ggctttctca gccaggcgtg gttactcaca cctgtaatcc     1040

cagcactttg ggagtccaag gtgggcggat cacctgaggt cgggagttcg agaccagcct     1100

gaccaacatg gagaagcccc gtctctacta aaaatgcaaa aaaaaattta gctaggcatg     1160

gcggcgcatg cctgcaatcc cagctacttg gaaggctgag gcaggagaat cacttgaacc     1220

caggaggtgg aggctgcggt gagccgagat tgcgccattg cactccagcc tgggcaacga     1280

gtgaaactcc gtctcaaaaa aaagaaaatg tctttctctt ccttttatat aaatatcgtt     1340

agggtgaagc attatggtct aatgattcaa atgttttaaa gtttaatgcc tagcagagaa     1400

ctgccttaaa aaaaaaaaaa aaaagttcat gttggccatg gtgaaagggt ttgatatgga     1460

gaaacaaaat cctcaggaaa ttagataaat aaaaatttat aagcatttgt attatttttt     1520

aataaactgc agggttacac aaaaatctag ctgatttaac ttgtattttg tcactttttt     1580

ataaaagttt attgtttgat gtttttaaag gtttttgaaa tccaggaatt aaatcatccc     1640

ttaataaaat attcgaaatt c                                               1661


<210>  2
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Ala Ser Gly Leu Arg Arg Gly His Pro Ala Gly Gly Glu 
1               5                   10                  15      


Glu Asn Met Thr Glu Thr Asp Ala Phe Tyr Lys Arg Glu Met Phe Asp 
            20                  25                  30          


Pro Ala Glu Lys Tyr Lys Met Asp His Arg Arg Arg Gly Ile Ala Leu 
        35                  40                  45              


Ile Phe Asn His Glu Arg Phe Phe Trp His Leu Thr Leu Pro Glu Arg 
    50                  55                  60                  


Arg Gly Thr Cys Ala Asp Arg Asp Asn Leu Thr Arg Arg Phe Ser Asp 
65                  70                  75                  80  


Leu Gly Phe Glu Val Lys Cys Phe Asn Asp Leu Lys Ala Glu Glu Leu 
                85                  90                  95      


Leu Leu Lys Ile His Glu Val Ser Thr Val Ser His Ala Asp Ala Asp 
            100                 105                 110         


Cys Phe Val Cys Val Phe Leu Ser His Gly Glu Gly Asn His Ile Tyr 
        115                 120                 125             


Ala Tyr Asp Ala Lys Ile Glu Ile Gln Thr Leu Thr Gly Leu Phe Lys 
    130                 135                 140                 


Gly Asp Lys Cys His Ser Leu Val Gly Lys Pro Lys Ile Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Asn Gln His Asp Val Pro Val Ile Pro Leu Asp 
                165                 170                 175     


Val Val Asp Asn Gln Thr Glu Lys Leu Asp Thr Asn Ile Thr Glu Val 
            180                 185                 190         


Asp Ala Ala Ser Val Tyr Thr Leu Pro Ala Gly Ala Asp Phe Leu Met 
        195                 200                 205             


Cys Tyr Ser Val Ala Glu Gly Tyr Tyr Ser His Arg Glu Thr Val Asn 
    210                 215                 220                 


Gly Ser Trp Tyr Ile Gln Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly 
225                 230                 235                 240 


Ser Ser Leu Glu Phe Thr Glu Leu Leu Thr Leu Val Asn Arg Lys Val 
                245                 250                 255     


Ser Gln Arg Arg Val Asp Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys 
            260                 265                 270         


Lys Gln Val Pro Cys Phe Ala Ser Met Leu Thr Lys Lys Leu His Phe 
        275                 280                 285             


Phe Pro Lys Ser Asn 
    290             


<210>  3
<211>  21845
<212>  DNA
<213>  Homo sapiens

<400>  3
cacatgcaag gcaactgggg taggtaatga ggaaaccaaa aaatgccact gctgtttcca       60

acgagtacaa caagatggta ataaccaata ttcattgagc tcttcacatg gcaggcagta      120

ttctgagtcc ttcacagtca cttaacccaa tcatcacaac caccatacaa gggaaatatg      180

gaaattccat gtctttgttg caggataagt tactaagaca gtgatttctg aaatatttta      240

tgcatacaat gaacagtaaa tggtttgagt aaaaaccctt ctttgatttc gtactctaat      300

gacatcaaga cttgaaccac aggcacatgt agaagttacc aaattagatt ttttctctcc      360

caaataatag tatgagatga gttccttata cttatttctt aagtattcat tatacttatt      420

ttaatatatt agaagtggtg ccttaacaca ttttaatttt tttcccactc taaggttgct      480

tacttttaaa attacaaggt ccagaggaat tacaaaagat aaagccaccg tttcatcaaa      540

tctgaaagca ttgtcaaagt aaatttttta caatagccaa ccacccaagg aggagctaaa      600

ttaaatccaa cattgagcac cccatggcac cttgttggca cactgtttgg ctgctatttt      660

tggggtagga caacatgctc tccccaggaa acaccattat ctagagaccc tcatcattct      720

gtgaatttct gcatggttct gtccctgaat tagctctacc tatgaaagcc agatttgaaa      780

aatccaggag aagccaggtg tcgtggctca tgcccgtaat cccaacattc tgggaggcca      840

aggtgggcag ataccaggtc gggagtttga taccagcctg accaacatgg agaaacccca      900

tctctactaa aaatacaaaa ttagccaggc atggtagtgc acgcctgtaa tcctagctac      960

ttgggaggcc aaggcaggag aatcgcttga acccgggcgg cagaggttgc ggtgagctga     1020

gatcatgcca ttgcactcca gcctgggcaa caacagctaa actgtctcaa aaaaaaaaaa     1080

aaaaaatcca ggagttacct ccagtttact ttggcccaag tttcatatac aaagaacatt     1140

taaaataagt tactgcaagt cctacaaagt aacttgcact ggggaaagga ctacacatga     1200

aacaggaaca tatatgccac cccctatggg atacctcaga gggatttcga gtttggttcc     1260

agaccaccaa taaaagagtc acacaaattt tctggtttcc cagtgcatat gaaagttttt     1320

catactaaag tgtagtctgt taagtgtgca ataacatgtc taaaaaaata atgtatatac     1380

cttaatttta aaatattgct aaaagatgct agggatcatc tgagccttca gcgagttata     1440

aatgttggtg tggggtattg ttgagggctg ctgactgatt agggtggtag ttgctgaagg     1500

ctgggatgac tggcaatctc ttaaaataag gcaataagga agtttgcttc atttttttgt     1560

ttgttttgag atggagtctc gttctgtcac tcaggctgga gtgcagtggc atgatcttgg     1620

ctcactgcaa cctctgcctc ctggttcaag tgattcttgt gcctcagcct cctgagtagc     1680

tgggattaca ggtgcctgcc accgtgcccg gctaattttt gttattttta gtagagacag     1740

ggttttgcca tgttggccag tctgggctcg aactcctggc ctcccaaagt cctgggatta     1800

caggcatgag ccactgcacc tggccatcca ttgattgttc cattcactaa agatttccct     1860

gtagcatgtg atgctgtttg gtagcatttt atccacagac cttctttcaa aattggggtc     1920

aatcccccca aaccctgcca ctgctttgtc aactaatacc ctgaatcctt tgttgtcatt     1980

taaacacaat tcacagcata ttcaccagga gtagattcta tctcaataaa ccactttctt     2040

tgctcatccg taaaaagcat ctcctcatct atcaaagttt tatcatgaga tggcaacaat     2100

gcagccacat tttcaggccc cacttccaat tctatttgtc ttgctacttc tgccacatct     2160

acagtgactt ccctcactga agtcttgaac ccctcaacat cagtgatgag gattggaatt     2220

aacttctttc aaactcctgt taatgtggag atatatgcat atacctatgt ataatgtatg     2280

tgtgtgtgta tatgtgtgtg tgtatatata tatatatata tatatatata tatatatata     2340

taaaatggat aggtatgttg tcctgcctgt aaaataccac ccagtgtgcc aattgaaata     2400

tatataattt ttaaatattt atatatgtat tttatatata ttatatatat atatatatat     2460

atatatatat attttttttt tttttttttt ttttttttta aagagtgtct tactctgtca     2520

cccagactgg agtgcagtgg cacagtcagc tgactgcagc ctcaaacttg ggctcaaata     2580

atcctgccat cttagtgtcc tgagttgctg ggaatacagg catgtgccac cactcttggc     2640

taattaaaaa aaaaaaaaaa ttgtagagac agggtcttgc attgttgcct aggctggtct     2700

caaaactcct ggcctcaagc aatccacctt ggcctcccaa agtgctgggt ttacaggcat     2760

gagccactgt ggctgataca tgtactttta atttttcgtt tttctttttt tccccctcta     2820

gtctctagtt acataccgta agtggatatt ttgacctccc atgaatcaca aatgttctta     2880

atggcatctc gaatgatgaa tcctttccag aagattttca atttactttg ctcagaacta     2940

tcagaggaat catgatgaca gctatagcct tatgaaatgt attttgtaaa taagacttga     3000

aagtcaaaat ttctccttga tccctgggct tcagaatgga tgttgtgtta gcaagcacga     3060

taacagcatc agtctctgta catctctatc agaactcttg gatgaccagg tgtattgtca     3120

atgaggagta atattttgaa aggaaccttt cttctgagca ctagagctca acagtgggct     3180

ttaaatattc tctaagccat gctgtaaata gatgtgctgt cactaactag cctttgttgg     3240

tccatttata gatcatattt agcataattc ttaagggcac taggattttc agaatggtaa     3300

aggaatgttg gctttaaagt catcagttgt attagcccct aacaagagca tcagcctgtt     3360

ctttgaagct ttgaagacag gcattgactt ctctctagct atgaaagtct tagatggaat     3420

cttcttccaa tagaaggccg tttcatatac atttaagatc tgttgttttg gctgggcacg     3480

gtggctcaca cctgtaatcc cagcactttg ggagaccgag gcgggcagat tgctcaaggt     3540

caggagttca agaccagcct ggccaaacat ggtgaaactc tgtctctact aaaaatacaa     3600

aattaacctg gacatggtgg cacatcctgt aatcccagtt acttgggagg ctgaggcaga     3660

agaatcgttt gaacccagga ggcagaggtt gcaaaagatc gcaccactgt actccagcct     3720

tggtgacaaa gcaagactgt ctcaaaaaca aaagattgtt gtttagtgta gctgccttta     3780

tcaatgattt tagctagatc tggataacct gatgcagctt ctacgttagc acctgctgct     3840

tcaccttgca cttttatgtc atgaagatag tttctttcct taaacctcag gaaccatcct     3900

ctctgctagc ttccagcttt tcttttgcaa ttccctcacc tctctcagcc tccatagaat     3960

tgaagagtta gggccttgct ctggattagg ctttggctta agggaatgtt gtggctgttt     4020

ttatcttcta tccagaccaa ctagaacttt ctccatatca gcaataaggc tgtttagctt     4080

tattgtcttt tgtgtgttta ctggagtagc atttttaatt tccttcaaaa ttttttcctt     4140

tgcattcatg acttggcttt tctcctttgc actcacaact tggctaactg gagcaagaag     4200

cctagctttc tgcctaccaa cattacttcc tcactaactt aatcatgttt gcttttgatt     4260

taaagtgaca ggctcttcct ttcatttgga cacttagagg cctttgtagg attattagtt     4320

ggcctaattt caaaattgtg tttccaggaa tagggaggcc ccaggagggg gagagagaag     4380

ggaaagttcg gtggaacagt ccaaacacat acagggctta tggattaatt tccccttcct     4440

ttatgagcgc ggttcatggt gccccaaaac aattgcaata atattaaaga ttactgatca     4500

cagatcacaa cagcagacat aataacaatg aaaaattttg aaatattgcg agagtaccaa     4560

aatgtgacac agagacacaa agcgagccaa tgttgaaata caggcagtat ctgctaagcg     4620

gtataaaaca atctatgcct gtacctctag aaagtacagg catagcaaag taaggaatag     4680

caaatgtttg gggcagctgg gattaaatga gtccgagctc acacaagtga tgtgaaattg     4740

cctcgggcta ggcggtctgt gtgtcccccc gggtggcaac tggcatgtcc ccagggcacg     4800

gttagtccca gcgggcctgg aggcgaagac cgcgtacctc tccctgcccc cgcgctcttg     4860

gtccccgcgg gctccggagc gactgggagg agctttaact ctgggaagga ccagcccgat     4920

ccacgggagc ccgggcggcg cgcaatcaga accaactggc cccacgctcg ggggcagggg     4980

gcggggccgc cgaggaaggg ccgagggcgg ggccgggccc gggagcctgt ggcttcagga     5040

agaggagggc aaggtgtctg gctgcgcgtt tggctgcaat gagctcggcc tcggggctcc     5100

gcagggggca cccggcaggt aggcaggggg cgtcgactgg gcaccgagca ggtctgcgtc     5160

ttgctccggc tggaggggaa acgagggtta gtggaccggg cgcgcggacc ggagtggggc     5220

cgcgggttcc ttcggctttg cagggcggcc tggagaagtt gcactcttgg attgaagcgc     5280

tcagggcggg tggggacggt ttcgcgcttc agtctaagaa acactcgggg acctggctgc     5340

cgcctcctgg cggtcccgag tagcgacgcc ggcgccgggg cgtgcccctg ccgcctttgt     5400

cctccggggc gatgagcgct ttcggggcgc cccggctgtt taaaccttaa aaggctgtcc     5460

ccacgcgggc ctggcgttcc cccacacctg gccgtttgaa atgttggggg ttggatcttt     5520

tgtttgctca cttcgaaaag tgaaaaggag gggttgttcc gccgagtcat aatgaaaaca     5580

taacaggccc gcggggtgcc cgggccaaga ccctgggtcc tcccgggctt cagctggagg     5640

cggccagttc ctggcggcca gcacaccccg gtatctctct tcttcatcca ggaaacctgc     5700

tgctgtctgt cggtttgagc caaaaccaca ataacttttt tctgcaaagt aatcaactgc     5760

taagagcgta cgttctgtca cttattactg gtaaagttta gaaacttcaa gcctggccag     5820

agtgaaacaa acaaaaaggt cgaaacgcct gcagttggcc ggccgtggtg gctcacgcct     5880

tgtaatccca acactttggg aggccgaggc gggcggatca ccagaggtcg ggagttctcg     5940

accagcctaa ctaacacggt gaaaccccgt ctctactaaa aatacaaaaa aattagccag     6000

gcctgggcgc aagctactgg ggaggctgag acaagagaat cgtttgaacc ctggaggtgg     6060

aggttgcagt gagccgagat cgccccactg cactccaacc tcggcgacag agtgagactt     6120

cgaatcaaga agaaaaaaaa aaaaaaagaa cgaaacgcct gcagttggtt agagtgcctt     6180

tgtttaagaa ctctttatat tttgctgcac aaaggaaatg gtgctccaga ggcaagctgt     6240

aaaagtcaca tggtcgtaga ggaggtagat aggtagcctt gtcctggagg cacagtgcag     6300

ggtccagttg cagtctctag gggcgggaag ccggggcttt ccttcactca cctgctccct     6360

tcctcttctt cctccaccgc actccccagt gcatgttcta ggcctgatgg aggttactct     6420

acatagggtt actaaataca ttgttgatgg agccgatggg tagattttca tagagagtgc     6480

agtgaatgaa gacgatgaca gtagaatgac cgaagtcgtt tgggaagttg aacaaagttt     6540

agaaaggtag ccggtctcgg gtgggagggg ctgcgtgggg atgggcctac agagactttg     6600

gaatctgtag gtgggctggc tttcaatccc agcttcactt tgccgacctt ggcacgcctg     6660

gcccactttc tctgtccctg ttcctgagct gtggagctgt gagataaggt atctaaggca     6720

tcaggccatc aacaaatggt agctggcagg attatctgga gggactatca aattagagtg     6780

aggtgaaaaa aggaatgatt agttttgtaa aacctaagct gatttaagga ataaggaggt     6840

ggcagttaca ttatcctgca aaggaagaga agtgaaaaga gggccagaca cagtggtggg     6900

cgcctctagt cccagctact ggggagactg aggcaggaga atcgcttgaa acctggaggt     6960

ggacttgcag tgagccaaga ttgcgccact gcactgcagc ctgggcgaca gagggaggct     7020

ctgtctcaaa aaaaaaaagt gaaaagaggt caagaatcag gtttaaagaa gggcacattt     7080

ttgataagta gattgcagat gaaaaggaat ttctatatct gttatacagg gtagctcctt     7140

cattaaaatt tattttctcc atatcaataa agctatttct tactttatcc aggtttttaa     7200

atattaacgc aggccgggcg tggtggctca tgcttgtaat cccagcactt ccaggaggct     7260

gaggcaggtg gatcacttga ggccaggagt tcaagaccag ccaggacaac atagcaaaac     7320

cctgtctcta ctgaaaatac aaaaaaaaag tagctgggtg tggtggcgca tgcctgtaat     7380

cccagctact caggaggctg aggcgggaga atcgcttgaa cccggaggcg gaggttgtgg     7440

tgagccgaga ccacgccact gcactccagc ctaggcaaca gagcaagact ccatcccaaa     7500

aagatagtaa taaaaaataa atattaatgc ggcataatga tacttaagtg cccccttctg     7560

gaaagcttgt cttcttggga tacacagctc aaggtggtca tgatgtgtta ttttctctca     7620

atctgtgggt aaagtttatc aactccagaa aagtattgga acttaggtcc tggcatctgt     7680

ctccatagct ttttgttctg attcagtgtt tgctagagtg gccactggac ctggtcatta     7740

actggtactg caggatgcag ggtgcacttt gtgagagtga aggtaagtta cagctggcca     7800

gcatcagaat tgggatgtcc agagcctagg tttttttcta catccgtagc attaacaaac     7860

aacaacaaca acaaaaaact taaaaaaaaa atccctcact gaggttgcca aatctgttaa     7920

ctttgaaact gaatgtatta agagatgggg tctagctctg ttacccaggc tggagtatgg     7980

tgactattca caggggcagt catagcacac tatgtcctag aactcttggg ctcaagagat     8040

cctcctgcct tggccttcca ggtaaccggg actataggct tgccactatg cccggccaga     8100

acgtcatttt aaacagattt tcttgagcag ctacttaata ctagttagcc attcctaaac     8160

ctgtaggtct tgactaatgt gagggcatat ttgagacaac ccaaactcac atcttaagtt     8220

attaatttta atgtgtcagc taacaactgg gaagctactt ctttggcaat atgagaaaca     8280

agagttttaa agacccaagc aagaatacat ctccagtgtt ttcaccctga gggatatgag     8340

ttagtttgct gagcagccat ttggcacagc ttccatgagt taggttgtga gccgccttcg     8400

gctcagcagt cagtatggag cagaagccac aggaggtgag ccgctggcct gctgccaccg     8460

aggaggacac tgagacatga gtgctttcca agttgtgcag aattttggca tgtgaggagg     8520

atggttgtga catatggatt taattttctt gaagttattg tttctttata ctctaattgg     8580

ttaaaagata agcaggtgag gttatcaaaa ggcagtagat tccgacagct tttgaaaatg     8640

ggaagagtga aatccctgtg ctgtcttcat agagcagtgt gtggagtagg aagtacctcg     8700

ttactgtgct cacctagggc aaaggtcgga ttaaacagct ttctcatctg ccatgcagcg     8760

gggaggacca gttggagagg ttgcttttgg ctctcacacc ttagtgtaaa aatcactttg     8820

tgaaaaatgc agctgtcacc tccttcctcc aagattctga ttctgcctca gttaggatcc     8880

aggaatctgc attttaacat gcacaccagg aattctgatg cccaaggttg agcaaaactg     8940

acttagggcg tacagacaga ggatgcctta gtgtggggtc ttagttgggt ctcattgctt     9000

ggggcagttc caggaggaat aggctaaaag ggacttgaac tgaattcccc accttgtatt     9060

ttttttgagg agaagtgagg ttagatcaat caggtgatgg gggctagtaa tggggagatc     9120

tctaaggaga ggggaaccaa cccttttggc taggagatga tgggtaagag tccatgcttt     9180

agggtcattc ttcctcaact gaagggtgca tcttgctata ctgctaatat ttcagtttat     9240

tcattgctgt ctcccctcta agctgttgag ctatcaggta aaaacagatg catgagtgga     9300

tggggccttt attgtagaag atgccacact ttgcactgtc cagtgtagaa gccactggcc     9360

aattcattta aattgacaat aaaatcgagt tcctcagttg cattagctgc atttaaatgc     9420

tcagtagaca catgtggcca gtggctacct tatgagacag tgcaaatacg gaacaattcc     9480

accatcacag acacttccat gacatagcac tgctctagag agtagagagg aattcagtgg     9540

aaggctgtcc agggagtagg gagtccagtt gagaatggag agcagagggc tccccttaca     9600

gggttggaaa tgcagatgtg tcatgcagga gatccaaggt ccaagtcttt gcccttgccc     9660

ttcccttcct ccacccaaac ttctacctct tccaggctta caccactgct aatccagcat     9720

taaccacaaa ctatatttca gttttcctgt aggacttaat tctttttcag aaaatgtgca     9780

aaaacatttt ctgcataaca aagcaacttc atatttcaac tccgtaatca cagaactgtt     9840

actctaggca tattttgcag tgaatgcatt tgtgtaatat tttctccatt tctgtttata     9900

agattgttat tttgcaggtc aagttggggg tgagaaagca tagagctgtt atagtttgtt     9960

tattagtaag cagtttccct tcatttcctt ttcttcacat actttggctt ttaaactaac    10020

caaaacagaa gggtcttaag agtttgggag tcagaagggg gatgggagtt cctactatat    10080

tttactgcca taagtaaaaa ataattaaca aaaatcaact ttttttaata ggtggggaag    10140

aaaacatgac agaaacagat gccttctata aaaggtaaag ctgtgctctt ttctaataaa    10200

ggtctcttcc tttgatggtc atgatcagcc tacagaaatc aaagcaagaa tgggtcctgg    10260

gagctaggaa gtaaaactga gtaggccaag ttttagcctt tggggagctc atttgtagat    10320

aggcaggttg tgctgcccct ggttgtcgag ggacccggag tgatgttcag aatgcatatt    10380

aattggcatg gcatgagcct agagctagaa cttggttctg agcctcgtgg ttattcctgg    10440

ttgctggatc ctgggggcca ggggaaagac atcaaggcag agggttaggg atgtgtcagg    10500

atggcacatg gctgctcttt accaattggc agagagatat ttcaggactt tccttattag    10560

catggccttt cctggagcac acccatggaa catcagcctg gcaaggagga agctcagatc    10620

tctatctaca tgttgaccta gaacttggag gggctcatta tttaatatga cttgaagtga    10680

ttgtttttca acttttcatt aacagagaaa tgtttgatcc ggcagaaaag tacaaaatgg    10740

accacaggag gagaggaatt gctttaatct tcaatcatga gaggttcttt tggcacttaa    10800

cactgccaga aaggcggggc acctgcgcag atagagacaa tcttacccgc aggtagtagt    10860

tttatctacc tatcaagatg aggcagttaa gtgataaaat tacttttggc caggtgtggt    10920

ggttcatgct ggtaatccca gcactttggg aagccaaggt gggaggatca cttaaggcaa    10980

ggagtttgag acaagtctgg gcaacagagt gagacctggt ctctacaaaa aataaaaatc    11040

aattagctgg gcatggtggc ggtagtccca gctactctgg aggctgaagg gggaggattg    11100

cttgatccca ggagttcaag gctgcacgga gctgtgatca tgccactgca ctccaggctg    11160

ggcaacagag tgagaccttg tctctaaaat aaaaaataaa ataatttttt tccatgtttc    11220

caaatgaaaa gttaaaaaaa attaaaaatt aaaaaaattc cagacttcta gatgtaggga    11280

aaagttactt atcataactt gtcaacacta atgaggtaac aacagatcaa gagtgttgga    11340

gcatgggcct tgctttgatg cagcctccct taagaacttg cctgagttgg ccgggcatgg    11400

tggctcactc ctgtaatccc ggcactttgg gaggctgagg cgggtggatc ataaggtcag    11460

gagattgaga ccatcctggc taacatggtg aaaccctgtc tctcctaaaa aatacaaaaa    11520

attagccggg cgtggtggtg ggagcctgta gtcccagcta ctcgggaggc tgaggcagga    11580

gaatggcatg aagccaggag gcggagcttg cagtgagcca agatcaagcc actgcactcc    11640

agcctgggcg acagagtgag cctctgtctc aaaaaaaaaa aaaaaaaaaa aacttgcctg    11700

agttattttc cttactctgt tctattaaat gttgacaggc ttttgcattt gtactaacat    11760

ttgcatagta gacaacaaca ctctaaattg aatcggctgt cattatgatt aaatcctttc    11820

cgaccatggt gaatgaaggg aaaaccacca ttgttatatt tcatttcttt tctcctaaag    11880

aaagcaaatt tatgtgtcgt taaaatgtgt atagattctt ccaaagtaag ggtatttgac    11940

aactttgaaa agtttatagg ctaacatttc atttaatata ccactaggtt ttcagatcta    12000

ggatttgaag tgaaatgctt taatgatctt aaagcagaag aactactgct caaaattcat    12060

gagggtaggt agttttgcta tcatatagtt catcttcctc taatgaaacc gagtccttta    12120

tcctatctgt aaagacaggt acaagtaatt acttgtgtga caaaaaaagt attaatttag    12180

cacaggttac aggttttggg tatgctgctg tgtttccgtt acccagcaca tttagagacc    12240

cttgcaaata attatgcctc taaagtttat atttagcata ccactagtta cagtctcttg    12300

tagaaatgaa tgaaatgacc ccttcaattg gcagtaaaag cctaaaatgc aagtactaca    12360

ggtgctgggc agtcaacagg ctcattttct cattgactcc tttcatgcct cattttctca    12420

ctggtttcca aatagtgttg gtttacatac attacctcct ttaattctca cagcgtcaat    12480

agggggtagg tattctaatt ataacaacct atattataat catcgctgca tgccaaccat    12540

tatatttgca taattacttt aaactttctt cagagctctt ctttaaactg cacatcattc    12600

taactttggc tgcttttacc agcttttcta ctttgctcag aagctttgga ggacatcagt    12660

ctcatggcac cgcacctggc tttgagtact cttttggaag ctctaagtgc tataatcttt    12720

tttttttttt tttgagatgg agtctcgctg tccgccccag gctggagtgc agtggtgtga    12780

tctcagctca ctgcagcctc cacctcctgg gttcaagcaa ttctcctgcc tcagcttccc    12840

aggtagctcg cccccatgcc cagctaattt ttgtattttt agtagagatg gggtttcacc    12900

gtgttggcca ggctggtctt gaacactggc ctcaagtgat ccacctgcct cggcctccca    12960

aaatgctggg attccaggcg tgagccactg cgcctggccc taagtgctgt attcctatag    13020

tgaaagtgca gcaatgcgtg gggagctgtt gagcagcagt ttctgggtct ttccactctg    13080

ctctaaggtc tctgctgatt caaggaaatt tttagtttat tgccaaaata acttggatct    13140

taagtgagat tccctatcgt aatcccttta tgttttccac atcattctgt gttttagaaa    13200

ggctaatgaa atttggtcaa actctattac tctgaacttt aataaatttg gattttttta    13260

aaaaaataag atacagtacg gtatattgtt tgattaaaga ctaagttgtt tcatcacaga    13320

tattttacac ttattaaaga gtaggccggg catggtggct catgcctgta atcccagcac    13380

tttgggaggc tgaggcgagg tggatcacct gaggtcagga gttcgagact agcctggcta    13440

catggcaaaa ccccgtctct actaaaaata caaaaattag ctggatatgg tttcaaatct    13500

gtaatcccag ctacttggga ggctgaggca ggagaatcgc ttgaacccgg gaggtggagg    13560

ttgcagtgag ccaagatcgc gccactgcac tccagccctg ggcaccaaga gtgaaactct    13620

gtctcaaaaa aacaaaaaag acaaaaccac aaattttcct cctccccaat catgtggatg    13680

taactttatt cttgtgttaa taaactgaat ttttatgtgt agataacaag catcatattt    13740

tcatttctat attctctttt gggtccttta tagtgtcaac tgttagccac gcagatgccg    13800

attgctttgt gtgtgtcttc ctgagccatg gcgaaggcaa tcacatttat gcatatgatg    13860

ctaaaatcga aattcagaca ttaactggct tgttcaaagg agacaagtgt cacagcctgg    13920

ttggaaaacc caagatattt atcattcagg taagactgag tacattatca tcttaattat    13980

aaagtctgtc attctgaaca tgtgataaag gtctaaaagc cagttttgaa agtaactttc    14040

tccagtaatt ggacaggccg tttttgaatt ctggccaatc atagttgcac tttgagctgt    14100

tagtaataat tctttgacac tctcattgtc tatattacaa aataacagca tttggattga    14160

gatttgaagt gactcacaaa gtaaccaatg tgctactccc tgtccgagcc tgataccaag    14220

gagagccatt ggaaagcgta cctgctgatt gaagagtgcc gcacaaggca acctcatcag    14280

actaggtttg cttctttggg aggtggagag catataaacc agtggaaaga atggaaaaat    14340

aaagccttct agtcttatcc tgtctcatcc ctttcacatt gccccttaaa ccaagattgt    14400

ttccccgctg ccaaattggt tttagggata aaagtatttt ttacaggcgt gatggctcac    14460

acctgtaatc ccagcacttt gggaggccga ggcaggcaga tcacctgagg agttcaagac    14520

cagcctggca aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgggcat    14580

ggtggcaggt gcctgtaatc ccagccattc gggaagctga ggcatgagaa ttgcttgaac    14640

ctgggaggca gaggctgtag ttagccgaga gcataccact gcactccagc ctgggcgtca    14700

gagcgagact ctgtctaaaa aaaaaaaaaa attttttttt ttgcatgaat attacttggc    14760

acatcattaa cgattttttt tttttttttg agatggagtc tcgctctgtc ccccaggctg    14820

gagtgcaatg gtgcaatctc ggctcactgc aacctccgcc cccaggttca attattctcc    14880

cacttcagcc tcccgagtag ctgggattac aggcacctgc catcatggct ggctaatttt    14940

tgtattttca tagagatggg gtttcaccat gttggctagt gtggtcttga actcctgacc    15000

tcaggtgatc tgcccgcctt ggcctcccag agtgttggga ttacaggcgt gagccactgt    15060

gcccggccaa agattttgaa ctacaaaaga gaaacctgac atgccagtgt cacaattctg    15120

tatttccatg aatagcatgg aggacatgaa ataacattat gttagtctat tcttgcattg    15180

ctataaagac ctgagactgg gtaatttata aggaagagag atttgattgg cctacagttc    15240

tgcaggctgt acaggaagca tggtgctggc atctgcttct ggtgaggcct taggaagctt    15300

acaattatgg tggaaggtga cagagagcca gcatatgact tgttgggagt gggagcaaga    15360

gagtgccaag ggagaggtcc cagactctct taagtaacca gatttcatgt gaactgagtg    15420

ggagctcact tacaccaaga ggatgatgct aaaccattca tgagagaccc tccccgatga    15480

tccagtcacc ttccaccagg cttcacctcc cacactggga accacatttt aacatgagat    15540

ttggagggga cagacgttca aaccgtatca aacatgaaac tgcatttcgc atcctaccat    15600

aaagccttgt tttggggtga ggaagtggct gtaagtgaag aatgactgcc tcgtttctgg    15660

tttggacaac tgcattggaa tgtctgtggg acatggaatt ggtcatacag gtgtagaacc    15720

taagacaggt ggcctcggct ggagaaataa atcaggaggt ggtcgtggaa gccatgggat    15780

tagatgagtt tactcgtgtt gaatacagcc tgaaaaagga gcataaaaca aaaccgaggg    15840

gcacccatga ggaatgggct gaagagggaa gatactgagg aggatggaca ccaggagaga    15900

aacaagaaac aaataatgac atgattgttt tgtgaaaagg ggagtggcca acactgtcaa    15960

acacaagaga attggaaata actaatgagc tactgtggga agaaagccac aaatgaaatc    16020

gttttccaag ttactttctc tctctatgcc ttagattctt ggtaaaaaga gcacctgcct    16080

catggggtgg ttgtgtgggc aaaatcacct gactgattta atgaatgcaa accacttaga    16140

acagtgcctg gcatacagca cgccctcagt aaaggctcgc tcttactctt attgcagttg    16200

actgggcagg tgatgtcatt aggttaaagg tgttctgtta tatttaggaa ggacagtaga    16260

aaaaaggcct gaaaataagc ctgctgatac gaagattaaa atctgcctat aaaaacggga    16320

tagtagggat tttctattta ttttatgatt tgaaatcatt caggactttc ttttgatgct    16380

cataattctt taaccatttc agaactgatt gatgcattta taatgctaca acagaatctt    16440

attggctggc tgtattcgtg tatagggtga ccataacaaa gtaccacaga ctgtgtggtt    16500

taaacagcag gaatttatcg tcacagtcct ggagctggaa gtctcagatg aacgtgtggg    16560

gaggattggt ttcttctgag gcctcccttt ttggcttgta ggtggccatc ttgtccctgt    16620

gccttcatat ggtctttctt ctgtgcatgt ctgtgtccca atttcttctt atgaagacac    16680

tagtcatgtt ggatttggtt tcacccgtat gacctcattt tccttaatca cctctaaagg    16740

ccctgtcttc caatacagtc agagttgagg tattggggct aggacttcaa catatgaatt    16800

tttggggaac acaattcagc ttgtaaaagt cacttatgag aagagtttaa tgttagcctc    16860

tgagtgagtc agaatttaat gttaattatg agtctaaatt taatgtaaat tctgagtgag    16920

tcagaattag tgggtaaaaa tttgagacct cactttttaa tgggcacaca aggaagatgg    16980

tgcattagta ggtatctcct caggtcaggc tggatgtcat tttaactcct aacaatttat    17040

agcagcagcc aggcaagcaa aagtcaatct ggaaatacac tgcctgccta aacagaaaca    17100

cttaggtcaa tactatagct ttcaaaaggg aaggtaacac cgtgtgccct gggtgtggtt    17160

aatctgtaag aaattttaaa accacaagct ttttcctcta cagtataccc ttctaccaac    17220

ataatttgat gtatacttgg ggatgccaat tttttcttaa aacattaact aaaagaaagc    17280

ctaagtaagg aaacaacttt gttggctttt gtgccctcca aacctgaatg tattgcttct    17340

gaactgctca gaatgtggtt tctgttgtaa tgaaggggta ctggcttaca cattcactgc    17400

acacattaag cactgggaag gaaacagtag gcaaagaggt gggtttttcc tccttgtctt    17460

gtaggcatgt cggggaaacc agcacgatgt gccagtcatt cctttggatg tagtagataa    17520

tcagacagag aagttggaca ccaacataac tgaggtggat gcagcctccg tttacacgct    17580

gcctgctgga gctgacttcc tcatgtgtta ctctgttgca gaaggtgtgt ggtgtttaaa    17640

acaaacatat aattgcctct cttggctaag gtcctgtaag tttcaccttt gattggtttg    17700

ggtcagatct ttcggttggg acatggtgat tccatcctga agctcacaga cttagaattt    17760

ctttgaccac atggcacaga gtgataaatg aaagtgtaaa gtaccttaca gaaaaataat    17820

tcctgagagt tatgttgagt aaagcaacag tctaattaat tatattagta ttagcagcct    17880

accatcagtt actgagggtg gtagtgccat tgtggtaatt gtcatggaaa gctttaattt    17940

tttttttttt tgagacaagg tctcaactct gtcactgagg ctgaagtgca atggcatgat    18000

catggctcac tgcagcctca atttctcagg ctcaagcaat cctcccacct cagcccccct    18060

gtagctggga ctataggcat gcaccaccat gcttggctaa ctttttaatt tttcggtaga    18120

gattgggtct tgctatgttg cccaggctgg tctcaaacaa tcctccagcc ttggcctccc    18180

aaagtgctgg gagtacaggt atgagccatt gcgtgcgtgc gtgcgttttt tttttttata    18240

gtctcactct gttgcccaga cgtgtgtgtg tgtgtgtatt tttttttttt tttaatagtc    18300

tcactctgtt gcccaggcgg gagtgcagtg gtccaatgtc agctcactgc aacctctgcc    18360

tcctgggttc aagtgattct cctacctcag cctcccgagt agctgggaat acaggtgcct    18420

gccaccacgc caagctaatt tttgtagttt tagtagagat ggggtttcac catgttggcc    18480

aggctggtct cgaactcctg acctcaagtg atctgcctgc ctcagcctcc caaagtgctg    18540

ggattatagg catgagccac catgcccaac tgaaaaatat tttgataatg gttctttgct    18600

tttgtagtaa ataattttga cttcttttta gtaatctcat gtctcaatca ttgtctatct    18660

tgggaatttt ttaggaaatg gaagaaatta tacagaatta accccgtgta tataaaacta    18720

tatagaatta atctcttttc ccatttgaaa agagtcaaaa aaatttaaaa gccatttata    18780

tcatggacac atcttaagac tcttctaagg atttttaaga acttatactt ctgtaactaa    18840

aaagaataca cacagtaatt gaaagccaga aaactgcagc aacattttcc ttctcacttt    18900

tttaggatat tattctcacc gggaaactgt gaacggctca tggtacattc aagatttgtg    18960

tgagatgttg ggaaaatatg gctcctcctt agagttcaca gaactcctca cactggtgaa    19020

caggaaagtt tctcagcgcc gagtggactt ttgcaaagac ccaagtgcaa ttggaaagaa    19080

gcaggttccc tgttttgcct caatgctaac taaaaagctg catttctttc caaaatctaa    19140

ttaattaata gaggctatct aattttacac tctgtattga aaatggcttt ctcagccagg    19200

cgtggttact cacacctgta atcccagcac tttgggagtc caaggtgggc ggatcacctg    19260

aggtcgggag ttcgagacca gcctgaccaa catggagaag ccccgtctct actaaaaatg    19320

caaaaaaaaa tttagctagg catggcggcg catgcctgca atcccagcta cttggaaggc    19380

tgaggcagga gaatcacttg aacccaggag gtggaggctg cggtgagccg agattgcgcc    19440

attgcactcc agcctgggca acgagtgaaa ctccgtctca aaaaaaagaa aatgtctttc    19500

tcttcctttt atataaatat cgttagggtg aagcattatg gtctaatgat tcaaatgttt    19560

taaagtttaa tgcctagcag agaactgcct taaaaaaaaa aaaaaaaagt tcatgttggc    19620

catggtgaaa gggtttgata tggagaaaca aaatcctcag gaaattagat aaataaaaat    19680

ttataagcat ttgtattatt ttttaataaa ctgcagggtt acacaaaaat ctagctgatt    19740

taacttgtat tttgtcactt ttttataaaa gtttattgtt tgatgttttt aaaggttttt    19800

gaaatccagg aattaaatca tcccttaata aaatattcga aattcatatt ttattacatt    19860

tttctaactc acattcttgt tcatttgtgt aattgataga tgttttttac tcggtcattt    19920

aaatgtttaa tatttcatct acatatgaat taccacattt tgtgtatgac tttaattcct    19980

actttaaaaa aaatcagcat tccagaattg ttgtatggca ttctgaggat gaaatagaaa    20040

acataattct tagccactat aggttgaaca cctgcaaaat ctgattctgt cagcatcttc    20100

catgttaagt tcctacaaac agtccaacag tcatcagacc cattcacaca caatcacatt    20160

aatagaataa cagatgttac tttcaaggtt caattcttat taatatgata tagaatctga    20220

ataatactgt tttgttaata atctgccaga ggctgaagaa agttaactgt tttggcttcg    20280

atacctgaaa cttgtgattt gcaggttcaa aagcaatcgt ttatatacac tgtttcagtt    20340

gaagttcaaa aagtaccaac tatactttat ggttggtgga acatttatgc ctttttgata    20400

aatgataaaa agatcttact cccaactact gcatattaaa aaaagaagtt aatgacaaga    20460

cgattccgtg ggaggttgag gcaggagggt tgcttgagcc caggagtttg atttggcaag    20520

acctggtctc tgattttttt aaaaggatga ttccaaatta agtctaagaa tggaagtgaa    20580

tgccaagcac agaccctttc acctccacat agagaataaa cgtgggacaa gctgacaagg    20640

atttttagct aacagcagcc accgttgctt tgatagacgc atacaagccc tttctaacat    20700

tagcaagtca taaaaatcca aaaagtaaaa atctcagttg agaacttcaa acaatacttc    20760

tgttttacaa gaatttaata acaaagatta aacaatcaaa atgaaccatg ggactcaaaa    20820

acatcctaag ttgcaaaatc aatacataat ggaaaatctg acgacattta aaactgtaag    20880

attaattctt ttcattgagt tcttctactt gcatttgcaa acagagagaa tgacgcgcct    20940

gtttcaggga ttctttagcc tgtcatggga aaaagaaaaa gcatgtgatc agaaagaaga    21000

gaaacatacc aacattactg cttgagagga attctataaa cttagcgtct ccttacagca    21060

ataaaatgtt taaactatta gtggcaaatg gctgaaatat atatatattt ttcttgagat    21120

ggggtttcat tctgtcaccc aggcaggagt gcagtgctac catctcagcc cactgcaacc    21180

tctgcctccc tggtgcaagt cattctcctg cctcagcctc ccaagtagct aggaccacag    21240

gtgcccacca ccatgcccac ctaatatttt ttggtatttt ttgtagagat ggagttttgc    21300

catgttgctc tggctggtct tgaactcctg gactcaagtg atttgcccac cttggcttcc    21360

caaagtgacg ggatataaat atttcaattt tatatgtgga tctttttaaa agatgagttt    21420

aagtttacta attcatcctt atgccttaaa aaaaaataca gtttataccc tttataatgg    21480

ttttccactt aatattctta aaaaaaaaac ccttaaccta ccactttatc tttttatctc    21540

cactttatta ccttaaacat aattaacaag gtgttatatt taaatttttt tattttagag    21600

atggggtctt gctctgttgc ccaggctgga gtgcagtggt gtgatcatag ttcactgcag    21660

ctttggaact cttgggttca agggatcttc ctgcttcagc ttcccaagta gctagggcta    21720

caagcatgtg ccaccatgtc cagctaattt aaaaacaaat tttgtagaga tgaggtctca    21780

ctatgttgac tagactggtc tccaatttct ggactcgaga tcctcccacc tcagcctccc    21840

aaatc                                                                21845


<210>  4
<211>  840
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(840)

<400>  4
atg gcc ttc tat aaa aga gaa atg ttt gat ccg gca gaa aag tac aaa         48
Met Ala Phe Tyr Lys Arg Glu Met Phe Asp Pro Ala Glu Lys Tyr Lys           
1               5                   10                  15                

atg gac cac agg agg aga gga att gct tta atc ttc aat cat gag agg         96
Met Asp His Arg Arg Arg Gly Ile Ala Leu Ile Phe Asn His Glu Arg           
            20                  25                  30                    

ttc ttt tgg cac tta aca ctg cca gaa agg cgg ggc acc tgc gca gat        144
Phe Phe Trp His Leu Thr Leu Pro Glu Arg Arg Gly Thr Cys Ala Asp           
        35                  40                  45                        

aga gac aat ctt acc cgc agg ttt tca gat cta gga ttt gaa gtg aaa        192
Arg Asp Asn Leu Thr Arg Arg Phe Ser Asp Leu Gly Phe Glu Val Lys           
    50                  55                  60                            

tgc ttt aat gat ctt aaa gca gaa gaa cta ctg ctc aaa att cat gag        240
Cys Phe Asn Asp Leu Lys Ala Glu Glu Leu Leu Leu Lys Ile His Glu           
65                  70                  75                  80            

gtg tca act gtt agc cac gca gat gcc gat tgc ttt gtg tgt gtc ttc        288
Val Ser Thr Val Ser His Ala Asp Ala Asp Cys Phe Val Cys Val Phe           
                85                  90                  95                

ctg agc cat ggc gaa ggc aat cac att tat gca tat gat gct aaa atc        336
Leu Ser His Gly Glu Gly Asn His Ile Tyr Ala Tyr Asp Ala Lys Ile           
            100                 105                 110                   

gaa att cag aca tta act ggc ttg ttc aaa gga gac aag tgt cac agc        384
Glu Ile Gln Thr Leu Thr Gly Leu Phe Lys Gly Asp Lys Cys His Ser           
        115                 120                 125                       

ctg gtt gga aaa ccc aag ata ttt atc att cag gca tgt cgg gga aac        432
Leu Val Gly Lys Pro Lys Ile Phe Ile Ile Gln Ala Cys Arg Gly Asn           
    130                 135                 140                           

cag cac gat gtg cca gtc att cct ttg gat gta gta gat aat cag aca        480
Gln His Asp Val Pro Val Ile Pro Leu Asp Val Val Asp Asn Gln Thr           
145                 150                 155                 160           

gag aag ttg gac acc aac ata act gag gtg gat gca gcc tcc gtt tac        528
Glu Lys Leu Asp Thr Asn Ile Thr Glu Val Asp Ala Ala Ser Val Tyr           
                165                 170                 175               

acg ctg cct gct gga gct gac ttc ctc atg tgt tac tct gtt gca gaa        576
Thr Leu Pro Ala Gly Ala Asp Phe Leu Met Cys Tyr Ser Val Ala Glu           
            180                 185                 190                   

gga tat tat tct cac cgg gaa act gtg aac ggc tca tgg tac att caa        624
Gly Tyr Tyr Ser His Arg Glu Thr Val Asn Gly Ser Trp Tyr Ile Gln           
        195                 200                 205                       

gat ttg tgt gag atg ttg gga aaa tat ggc tcc tcc tta gag ttc aca        672
Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly Ser Ser Leu Glu Phe Thr           
    210                 215                 220                           

gaa ctc ctc aca ctg gtg aac agg aaa gtt tct cag cgc cga gtg gac        720
Glu Leu Leu Thr Leu Val Asn Arg Lys Val Ser Gln Arg Arg Val Asp           
225                 230                 235                 240           

ttt tgc aaa gac cca agt gca att gga aag aag cag gtt ccc tgt ttt        768
Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys Lys Gln Val Pro Cys Phe           
                245                 250                 255               

gcc tca atg cta act aaa aag ctg cat ttc ttt cca aaa tct aat ctc        816
Ala Ser Met Leu Thr Lys Lys Leu His Phe Phe Pro Lys Ser Asn Leu           
            260                 265                 270                   

gag cac cac cac cac cac cac tga                                        840
Glu His His His His His His                                               
        275                                                               


<210>  5
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Phe Tyr Lys Arg Glu Met Phe Asp Pro Ala Glu Lys Tyr Lys 
1               5                   10                  15      


Met Asp His Arg Arg Arg Gly Ile Ala Leu Ile Phe Asn His Glu Arg 
            20                  25                  30          


Phe Phe Trp His Leu Thr Leu Pro Glu Arg Arg Gly Thr Cys Ala Asp 
        35                  40                  45              


Arg Asp Asn Leu Thr Arg Arg Phe Ser Asp Leu Gly Phe Glu Val Lys 
    50                  55                  60                  


Cys Phe Asn Asp Leu Lys Ala Glu Glu Leu Leu Leu Lys Ile His Glu 
65                  70                  75                  80  


Val Ser Thr Val Ser His Ala Asp Ala Asp Cys Phe Val Cys Val Phe 
                85                  90                  95      


Leu Ser His Gly Glu Gly Asn His Ile Tyr Ala Tyr Asp Ala Lys Ile 
            100                 105                 110         


Glu Ile Gln Thr Leu Thr Gly Leu Phe Lys Gly Asp Lys Cys His Ser 
        115                 120                 125             


Leu Val Gly Lys Pro Lys Ile Phe Ile Ile Gln Ala Cys Arg Gly Asn 
    130                 135                 140                 


Gln His Asp Val Pro Val Ile Pro Leu Asp Val Val Asp Asn Gln Thr 
145                 150                 155                 160 


Glu Lys Leu Asp Thr Asn Ile Thr Glu Val Asp Ala Ala Ser Val Tyr 
                165                 170                 175     


Thr Leu Pro Ala Gly Ala Asp Phe Leu Met Cys Tyr Ser Val Ala Glu 
            180                 185                 190         


Gly Tyr Tyr Ser His Arg Glu Thr Val Asn Gly Ser Trp Tyr Ile Gln 
        195                 200                 205             


Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly Ser Ser Leu Glu Phe Thr 
    210                 215                 220                 


Glu Leu Leu Thr Leu Val Asn Arg Lys Val Ser Gln Arg Arg Val Asp 
225                 230                 235                 240 


Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys Lys Gln Val Pro Cys Phe 
                245                 250                 255     


Ala Ser Met Leu Thr Lys Lys Leu His Phe Phe Pro Lys Ser Asn Leu 
            260                 265                 270         


Glu His His His His His His 
        275                 


