                         SEQUENCE LISTING

<110>  Heinrichs, Volker
       Williams, Jayme
 
<120>  AXMI205 VARIANT PROTEINS AND METHODS FOR THEIR USE

<130>  APA116029

<150>  61/512,539
<151>  2011-07-28

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  1608
<212>  DNA
<213>  Chromobacterium sp.

<400>  1
atggcatccg cagcaaatgc aggtcagctt ggcaacctcc ccggcgttac ttccatgggc       60

atgggctatg acgtgaatgg tttgtacgcc agcccggaaa gcctgcttgg ccaacccttg      120

ttcgatttcg gcggcgagct ggacagcatc gaaatcgagg gccgcagcta cacctttccc      180

cgcagcatgc atgtacacac ctatttccat tccgacttca aacaggatgt cagcaaggaa      240

atcgaagagt atcgggagaa aatgagccag cacgtgggcg tgtccggccg ctacaagttg      300

ttcagcgctt cgctgagcgt ggatttcacc accacggacc agcaactgac cgagattacc      360

tacagctcca cccgcgaagc ccatgtgctg tggtacatca gcctgcctgg cgcggccacg      420

ctgcgttcga tgctgcgccg cgatttccgc gacgacctga acaaccccaa tatgccggcc      480

atggagctgt tcaagcgcta tggtccctac tacatatcgg aagcggcggt gggcggccgg      540

ctggactaca gcgcggccag caagaccttg aagatggaca gcagccagtc gctgtccacc      600

accgccgaaa tgtcctacaa ggcgctggtg ggcgagatca agatcgagca tggctcggag      660

atggaaaagc aggtcaacag cttccgcagc aactccacca tccgtctcac cgccaccggc      720

ggcaagccgg gcatgaccga tcgcatactg cacggtccgg attcgcagca ggcgttctcg      780

caatgggcgg aatcgctgct cgactatgcg acgctgatgg acttttccac cgaaagcctg      840

caaccgatct gggcgctggc cgacaagccc gagcgccgcg tcgagcttga ggacgccttc      900

cccgaattca tgaagcagtc gcagcagtcc atccccaagg tggacaaggt gctgctgatg      960

gacgcgcggc cgcctatggt gaaggctggg gaggatagcg gctccggcgc gtcggaggat     1020

ctggctgtgt tcaatcccag cacctccaat ggctacaaga tggttggcca gttcggtcag     1080

cgcaaccatg ccagcgtggc ggatggccat gcgccgattt tcaaggatct gttcgatctg     1140

ggcgtgctga aggcgccggt gggttggcag cgggtgtggg acgacgccgg ctccggcaag     1200

tccaaggact acgcgtgctg gcgcgcgatt ccgccgcagg gctaccgcgc gctgggcgat     1260

gtgatgatgc tggccaccag cggctataac ccgccgaatc tgccggacta tgtttgcgtg     1320

catcaaagcc tgtgcgcgga tgtgcagacg ctgcaaaacc gggtgtggtg ggacaagggc     1380

accggcgcgc gcaaggatgt cagcctgtgg caaccgggcg cggccggcgc ggtggcgtcc     1440

tcttgcttcg ccggcgtgcc taattacaac aacccgccca attccggcga catcgagcgc     1500

ttgcgcggca gcatcgcatg cgtgaagacc agcgcgatcg cgtccatgca ggaaatgaag     1560

tccatgctca gccagcacca aggcatggaa gcgatgatgt ccaagctg                  1608


<210>  2
<211>  536
<212>  PRT
<213>  Chromobacterium sp.

<400>  2

Met Ala Ser Ala Ala Asn Ala Gly Gln Leu Gly Asn Leu Pro Gly Val 
1               5                   10                  15      


Thr Ser Met Gly Met Gly Tyr Asp Val Asn Gly Leu Tyr Ala Ser Pro 
            20                  25                  30          


Glu Ser Leu Leu Gly Gln Pro Leu Phe Asp Phe Gly Gly Glu Leu Asp 
        35                  40                  45              


Ser Ile Glu Ile Glu Gly Arg Ser Tyr Thr Phe Pro Arg Ser Met His 
    50                  55                  60                  


Val His Thr Tyr Phe His Ser Asp Phe Lys Gln Asp Val Ser Lys Glu 
65                  70                  75                  80  


Ile Glu Glu Tyr Arg Glu Lys Met Ser Gln His Val Gly Val Ser Gly 
                85                  90                  95      


Arg Tyr Lys Leu Phe Ser Ala Ser Leu Ser Val Asp Phe Thr Thr Thr 
            100                 105                 110         


Asp Gln Gln Leu Thr Glu Ile Thr Tyr Ser Ser Thr Arg Glu Ala His 
        115                 120                 125             


Val Leu Trp Tyr Ile Ser Leu Pro Gly Ala Ala Thr Leu Arg Ser Met 
    130                 135                 140                 


Leu Arg Arg Asp Phe Arg Asp Asp Leu Asn Asn Pro Asn Met Pro Ala 
145                 150                 155                 160 


Met Glu Leu Phe Lys Arg Tyr Gly Pro Tyr Tyr Ile Ser Glu Ala Ala 
                165                 170                 175     


Val Gly Gly Arg Leu Asp Tyr Ser Ala Ala Ser Lys Thr Leu Lys Met 
            180                 185                 190         


Asp Ser Ser Gln Ser Leu Ser Thr Thr Ala Glu Met Ser Tyr Lys Ala 
        195                 200                 205             


Leu Val Gly Glu Ile Lys Ile Glu His Gly Ser Glu Met Glu Lys Gln 
    210                 215                 220                 


Val Asn Ser Phe Arg Ser Asn Ser Thr Ile Arg Leu Thr Ala Thr Gly 
225                 230                 235                 240 


Gly Lys Pro Gly Met Thr Asp Arg Ile Leu His Gly Pro Asp Ser Gln 
                245                 250                 255     


Gln Ala Phe Ser Gln Trp Ala Glu Ser Leu Leu Asp Tyr Ala Thr Leu 
            260                 265                 270         


Met Asp Phe Ser Thr Glu Ser Leu Gln Pro Ile Trp Ala Leu Ala Asp 
        275                 280                 285             


Lys Pro Glu Arg Arg Val Glu Leu Glu Asp Ala Phe Pro Glu Phe Met 
    290                 295                 300                 


Lys Gln Ser Gln Gln Ser Ile Pro Lys Val Asp Lys Val Leu Leu Met 
305                 310                 315                 320 


Asp Ala Arg Pro Pro Met Val Lys Ala Gly Glu Asp Ser Gly Ser Gly 
                325                 330                 335     


Ala Ser Glu Asp Leu Ala Val Phe Asn Pro Ser Thr Ser Asn Gly Tyr 
            340                 345                 350         


Lys Met Val Gly Gln Phe Gly Gln Arg Asn His Ala Ser Val Ala Asp 
        355                 360                 365             


Gly His Ala Pro Ile Phe Lys Asp Leu Phe Asp Leu Gly Val Leu Lys 
    370                 375                 380                 


Ala Pro Val Gly Trp Gln Arg Val Trp Asp Asp Ala Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Lys Asp Tyr Ala Cys Trp Arg Ala Ile Pro Pro Gln Gly Tyr Arg 
                405                 410                 415     


Ala Leu Gly Asp Val Met Met Leu Ala Thr Ser Gly Tyr Asn Pro Pro 
            420                 425                 430         


Asn Leu Pro Asp Tyr Val Cys Val His Gln Ser Leu Cys Ala Asp Val 
        435                 440                 445             


Gln Thr Leu Gln Asn Arg Val Trp Trp Asp Lys Gly Thr Gly Ala Arg 
    450                 455                 460                 


Lys Asp Val Ser Leu Trp Gln Pro Gly Ala Ala Gly Ala Val Ala Ser 
465                 470                 475                 480 


Ser Cys Phe Ala Gly Val Pro Asn Tyr Asn Asn Pro Pro Asn Ser Gly 
                485                 490                 495     


Asp Ile Glu Arg Leu Arg Gly Ser Ile Ala Cys Val Lys Thr Ser Ala 
            500                 505                 510         


Ile Ala Ser Met Gln Glu Met Lys Ser Met Leu Ser Gln His Gln Gly 
        515                 520                 525             


Met Glu Ala Met Met Ser Lys Leu 
    530                 535     


<210>  3
<211>  536
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Axmi205(evo25) mutant

<400>  3

Met Ala Ser Ala Ala Asn Ala Gly Gln Leu Gly Asn Leu Pro Gly Val 
1               5                   10                  15      


Thr Ser Met Gly Met Gly Tyr Asp Val Asn Gly Leu Tyr Ala Ser Pro 
            20                  25                  30          


Glu Ser Leu Leu Gly Gln Pro Leu Phe Asp Phe Gly Gly Glu Leu Asp 
        35                  40                  45              


Ser Ile Glu Ile Glu Gly Arg Ser Tyr Thr Phe Pro Arg Ser Met His 
    50                  55                  60                  


Val His Thr Tyr Phe His Ser Asp Phe Lys Gln Asp Val Ser Lys Glu 
65                  70                  75                  80  


Ile Glu Glu Tyr Arg Glu Lys Met Ser Gln His Val Gly Val Ser Gly 
                85                  90                  95      


Arg Tyr Lys Leu Phe Ser Ala Ser Leu Ser Val Asp Phe Thr Thr Thr 
            100                 105                 110         


Asp Gln Gln Leu Thr Glu Ile Thr Tyr Ser Ser Thr Arg Glu Ala His 
        115                 120                 125             


Val Leu Trp Tyr Ile Ser Leu Pro Gly Ala Ala Thr Leu Arg Ser Met 
    130                 135                 140                 


Leu Arg Arg Asp Phe Arg Asp Asp Leu Asn Asn Pro Asn Met Pro Ala 
145                 150                 155                 160 


Met Glu Leu Phe Lys Arg Tyr Gly Pro Tyr Tyr Ile Ser Glu Ala Ala 
                165                 170                 175     


Val Gly Gly Arg Leu Asp Tyr Ser Ala Ala Ser Lys Thr Leu Lys Met 
            180                 185                 190         


Asp Ser Ser Gln Ser Leu Ser Thr Thr Ala Glu Met Ser Tyr Lys Ala 
        195                 200                 205             


Leu Val Gly Glu Ile Lys Ile Glu His Gly Ser Glu Met Glu Lys Gln 
    210                 215                 220                 


Val Asn Ser Phe Arg Ser Asn Ser Thr Ile Arg Leu Thr Ala Thr Gly 
225                 230                 235                 240 


Gly Lys Pro Gly Met Thr Asp Arg Ile Leu His Gly Pro Asp Ser Gln 
                245                 250                 255     


Gln Ala Phe Ser Gln Trp Ala Glu Ser Leu Leu Asp Tyr Ala Thr Leu 
            260                 265                 270         


Met Asp Phe Ser Thr Glu Ser Leu Gln Pro Ile Trp Ala Leu Ala Asp 
        275                 280                 285             


Lys Pro Glu Arg Arg Val Glu Leu Glu Asp Ala Phe Pro Glu Phe Met 
    290                 295                 300                 


Lys Gln Ser Gln Gln Ser Ile Pro Lys Val Asp Lys Val Leu Leu Met 
305                 310                 315                 320 


Asp Ala Arg Pro Pro Met Val Lys Ala Gly Glu Asp Ser Gly Ser Gly 
                325                 330                 335     


Ala Ser Glu Asp Leu Ala Val Phe Asn Pro Ser Thr Ser Asn Gly Tyr 
            340                 345                 350         


Lys Met Val Gly Gln Phe Gly Gln Arg Asn His Ala Ser Val Ala Asp 
        355                 360                 365             


Gly His Ala Pro Ile Phe Lys Asp Leu Phe Asp Leu Gly Val Leu Lys 
    370                 375                 380                 


Ala Pro Val Gly Trp Gln Arg Val Trp Asp Asp Ala Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Lys Asp Tyr Ala Cys Trp Arg Ala Ile Pro Pro Gln Gly Tyr Arg 
                405                 410                 415     


Ala Leu Gly Asp Val Met Met Leu Ala Thr Ser Gly Tyr Asn Pro Pro 
            420                 425                 430         


Asn Leu Pro Asp Tyr Val Cys Val His Gln Ser Leu Cys Ala Asp Val 
        435                 440                 445             


Gln Thr Leu Gln Asn Arg Val Trp Trp Asp Lys Gly Thr Gly Ala Arg 
    450                 455                 460                 


Lys Asp Ala Ser Leu Trp Gln Pro Gly Ala Ala Gly Ala Val Ala Ser 
465                 470                 475                 480 


Ser Cys Phe Ala Gly Val Pro Asn Tyr Asn Asn Pro Pro Asn Ser Gly 
                485                 490                 495     


Asp Ile Glu Arg Leu Arg Gly Ser Ile Ala Cys Val Lys Thr Ser Ala 
            500                 505                 510         


Ile Ala Ser Met Gln Glu Met Lys Ser Met Leu Ser Gln His Gln Gly 
        515                 520                 525             


Met Glu Ala Met Met Ser Lys Leu 
    530                 535     


<210>  4
<211>  1611
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleotide sequence encoding Axmi205(evo30)

<400>  4
atggcatccg cagcaaatgc aggtcagctt ggcaacctcc ccggcgttac ttccatgggc       60

atgggctatg acgtgaatgg tttgtacgcc agcccggaaa gcctgcttgg ccaacccttg      120

ttcgatttcg gcggcgagct ggacagcatc gaaatcgagg gccgcagcta cacctttccc      180

cgcagcatgc atgtacacac ctatttccat tccgacttca aacaggatgt cagcaaggaa      240

atcgaagagt atcgggagaa aatgagccag cacgtgggcg tgtccggccg ctacaagttg      300

ttcagcgctt cgctgagcgt ggatttcacc accacggacc agcaactgac cgagattacc      360

tacagctcca cccgcgaagc ccatgtgctg tggtacatca gcctgcctgg cgcggccacg      420

ctgcgttcga tgctgcgccg cgatttccgc gacgacctga acaaccccaa tatgccggcc      480

atggagctgt tcaagcgcta tggtccctac tacatatcgg aagcggcggt gggcggccgg      540

ctggactaca gcgcggccag caagaccttg aagatggaca gcagccagtc gctgtccacc      600

accgccgaaa tgtcctacaa ggcgctggtg ggcgagatca agatcgagca tggctcggag      660

atggaaaagc aggtcaacag cttccgcagc aactccacca tccgtctcac cgccaccggc      720

ggcaagccgg gcatgaccga tcgcatactg cacggtccgg attcgcagca ggcgttctcg      780

caatgggcgg aatcgctgct cgactatgcg acgctgatgg acttttccac cgaaagcctg      840

caaccgatct gggcgctggc cgacaagccc gagcgccgcg tcgagcttga ggacgccttc      900

cccgaattca tgaagcagtc gcagcagtcc atccccaagg tggacaaggt gctgctgatg      960

gacgcgcggc cgcctatggt gaaggctggg gaggatagcg gctccggcgc gtcggaggat     1020

ctggctgtgt tcaatcccag cacctccaat ggctacaaga tggttggcca gttcggtcag     1080

cgcaaccatg ccagcgtggc ggatggccat gcgccgattt tcaaggatct gttcgatctg     1140

ggcgtgctga aggcgccggt gggttggcag cgggtgtggg acgacgccgg ctccggcaag     1200

tccaaggact acgcgtgctg gcgcgcgatt ccgccgcagg gctaccgcgc gctgggcgat     1260

gtgatgatgc tggccaccag cggctataac ccgccgaatc tgccggacta tgtttgcgtg     1320

catcaaagcc tgtgcgcgga tgtgcagacg ctgcaaaacc gggtgtggtg ggacaagggc     1380

accggcgcgc gcaaggattt gagcctgtgg caaccgggcg cggccggcgc ggtggcgtcc     1440

tcttgcttcg ccggcgtgcc taattacaac aacccgccca attccggcga catcgagcgc     1500

ttgcgcggca gcatcgcatg cgtgaagacc agcgcgatcg cgtccatgca ggaaatgaag     1560

tccatgctca gccagcacca aggcatggaa gcgatgatgt ccaagctgtg a              1611


<210>  5
<211>  1755
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding Axmi205(evo34)

<400>  5
atggcatccg cagcaaatgc aggtcagctt ggcaacctcc ccggcgttac ttccatgggc       60

atgggctatg acgtgaatgg tttgtacgcc agcccggaaa gcctgcttgg ccaacccttg      120

ttcgatttcg gcggcgagct ggacagcatc gaaatcgagg gccgcagcta cacctttccc      180

cgcagcatgc atgtacacac ctatttccat tccgacttca aacaggatgt cagcaaggaa      240

atcgaagagt atcggaccaa aatgagccag cacgtgggcg tgtccggccg ctacaagttg      300

ttcagcgctt cgctgagcgt ggatttcacc accacggacc agcaactgac cgagattacc      360

tacagctcca cccgcgaagc ccatgtgctg tggtacatca gcctgcctgg cgcggccacg      420

ctgcgttcga tgctgcgccg cgatttccgc gacgacctga acaaccccaa tatgccggcc      480

atggagctgt tcaagcgcta tggtccctac tacatatcgg aagcggcggt gggcggccgg      540

ctggactaca gcgcggccag caagaccttg aagatggaca gcagccagtc gctgtccacc      600

accgccgaaa tgtcctacaa ggcgctggtg ggcgagatca agatcgagca tggctcggag      660

atggaaaagc aggtcaacag cttccgcagc aactccacca tccgtctcac cgccaccggc      720

ggcaagccgg gcatgaccga tcgcatactg cacggtccgg attcgcagca ggcgttctcg      780

caatgggcgg aatcgctgct cgactatgcg acgctgatgg acttttccac cgaaagcctg      840

caaccgatct gggcgctggc cgacaagccc gagcgccgcg tcgagcttga ggacgccttc      900

cccgaattca tgaagcagtc gcagcagtcc atccccaagg tggacaaggt gctgctgatg      960

gacgcgcggc cgcctatggt gaaggctggg gaggatagcg gctccggcgc gtcggaggat     1020

ctggctgtgt tcaatcccag cacctccaat ggctacaaga tggttggcca gttcggtcag     1080

cgcaaccatg ccagcgtggc ggatggccat gcgccgattt tcaaggatct gttcgatctg     1140

ggcgtgctga aggcgccggt gggttggcag cgggtgtggg acgacgccgg ctccggcaag     1200

tccaaggact acgcgtgctg gcgcgcgatt ccgccgcagg gctaccgcgc gctgggcgat     1260

gtgatgatgc tggccaccag cggctataac ccgccgaatc tgccggacta tgtttgcgtg     1320

catcaaagcc tgtgcgcgga tgtgcagacg ctgcaaaacc gggtgtggtg ggacaagggc     1380

accggcgcgc gcaaggatgt cagcctgtgg caaccgggcg cggccggcgc ggtggcgtcc     1440

tcttgcttcg ccggcgtgcc taattacaac aacccgccca attccggcga catcgagcgc     1500

ttgcgcggca gcatcgcatg cgtgaagacc agcgcgatcg cgtccatgca ggaaatgaag     1560

tccatgctca gccagcacca aggcatggaa gcgatgatgt ccaagctgtg atcggcgcgc     1620

cggtcgacaa gcttgcggcc gcactcgagt ctggtaaaga aaccgctgct gcgaaatttg     1680

aacgccagca catggactcg tctactagcg cagcttaatt aacctaggct gctgccaccg     1740

ctgagcaata actag                                                      1755


<210>  6
<211>  1608
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding Axmi205(evo35)

<400>  6
atggcatccg cagcaaatgc aggtcagctt ggcaacctcc ccggcgttac ttccatgggc       60

atgggctatg acgtgaatgg tttgtacgcc agcccggaaa gcctgcttgg ccaacccttg      120

ttcgatttcg gcggcgagct ggacagcatc gaaatcgagg gccgcagcta cacctttccc      180

cgcagcatgc atgtacacac ctatttccat tccgacttca aacaggatgt cagcaaggaa      240

atcgaagagt atcgggagaa aatgagccag cacgtgggcg tgtccggccg ctacaagttg      300

ttcagcgctt cgctgagcgt ggatttcacc accacggacc agcaactgac cgagattacc      360

tacagctcca cccgcgaagc ccatgtgctg tggtacatca gcctgcctgg cgcggccacg      420

ctgcgttcga tgctgcgccg cgatttccgc gacgacctga acaaccccaa tatgccggcc      480

atggagctgt tcaagcgcta tggtccctac tacatatcgg aagcggcggt gggcggccgg      540

ctggactaca gcgcggccag caagaccttg aagatggaca gcagccagtc gctgtccacc      600

accgccgaaa tgtcctacaa ggcgctggtg ggcgagatca agatcgagca tggctcggag      660

atggaaaagc aggtcaacag cttccgcagc aactccacca tccgtctcac cgccaccggc      720

ggcaagccgg gcatgaccga tcgcatactg cacggtccgg attcgcagca ggcgttctcg      780

caatgggcgg aatcgctgct cgactatgcg acgctgatgg acttttccac cgaaagcctg      840

caaccgatct gggcgctggc cgacaagccc gagcgccgcg tcgagcttga ggacgccttc      900

cccgaattca tgaagcagtc gcagcagtcc atccccaagg tggacaaggt gctgctgatg      960

gacgcgcggc cgcctatggt gaaggctggg gaggatagcg gctccggcgc gtcggaggat     1020

ctggctgtgt tcaatcccag cacctccaat ggctacaaga tggttggcca gttcggtcag     1080

cgcaaccatg ccagcgtggc ggatggccat gcgccgattt tcaaggatct gttcgatctg     1140

ggcgtgctga aggcgccggt gggttggcag cgggtgtggg acgacgccgg ctccggcaag     1200

tccaaggact acgcgtgctg gcgcgcgatt ccgccgcagg gctaccgcgc gctgggcgat     1260

gtgatgatgc tggccaccag cggctataac ccgccgaatc tgccggacta tgtttgcgtg     1320

catcaaagcc tgtgcgcgga tgtgcagacg ctgcaaaacc gggtgtggtg ggacaagggc     1380

accggcgcgc gcaaggatgt cagcctgtgg caaccgggcg cggccggcgc ggtggcgtcc     1440

tcttgcttcg ccggcgtgcc taattacaac aacccgccca attccggcga catcgagcgc     1500

ttgcgcggca gcatcgcatg cgtgaagacc agcgcgatcg cgtccatgcg ggaaatgaag     1560

tccatgctca gccagcacca aggcatggaa gcgatgatgt ccaagctg                  1608


<210>  7
<211>  536
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Axmi205(evo30) mutant

<400>  7

Met Ala Ser Ala Ala Asn Ala Gly Gln Leu Gly Asn Leu Pro Gly Val 
1               5                   10                  15      


Thr Ser Met Gly Met Gly Tyr Asp Val Asn Gly Leu Tyr Ala Ser Pro 
            20                  25                  30          


Glu Ser Leu Leu Gly Gln Pro Leu Phe Asp Phe Gly Gly Glu Leu Asp 
        35                  40                  45              


Ser Ile Glu Ile Glu Gly Arg Ser Tyr Thr Phe Pro Arg Ser Met His 
    50                  55                  60                  


Val His Thr Tyr Phe His Ser Asp Phe Lys Gln Asp Val Ser Lys Glu 
65                  70                  75                  80  


Ile Glu Glu Tyr Arg Glu Lys Met Ser Gln His Val Gly Val Ser Gly 
                85                  90                  95      


Arg Tyr Lys Leu Phe Ser Ala Ser Leu Ser Val Asp Phe Thr Thr Thr 
            100                 105                 110         


Asp Gln Gln Leu Thr Glu Ile Thr Tyr Ser Ser Thr Arg Glu Ala His 
        115                 120                 125             


Val Leu Trp Tyr Ile Ser Leu Pro Gly Ala Ala Thr Leu Arg Ser Met 
    130                 135                 140                 


Leu Arg Arg Asp Phe Arg Asp Asp Leu Asn Asn Pro Asn Met Pro Ala 
145                 150                 155                 160 


Met Glu Leu Phe Lys Arg Tyr Gly Pro Tyr Tyr Ile Ser Glu Ala Ala 
                165                 170                 175     


Val Gly Gly Arg Leu Asp Tyr Ser Ala Ala Ser Lys Thr Leu Lys Met 
            180                 185                 190         


Asp Ser Ser Gln Ser Leu Ser Thr Thr Ala Glu Met Ser Tyr Lys Ala 
        195                 200                 205             


Leu Val Gly Glu Ile Lys Ile Glu His Gly Ser Glu Met Glu Lys Gln 
    210                 215                 220                 


Val Asn Ser Phe Arg Ser Asn Ser Thr Ile Arg Leu Thr Ala Thr Gly 
225                 230                 235                 240 


Gly Lys Pro Gly Met Thr Asp Arg Ile Leu His Gly Pro Asp Ser Gln 
                245                 250                 255     


Gln Ala Phe Ser Gln Trp Ala Glu Ser Leu Leu Asp Tyr Ala Thr Leu 
            260                 265                 270         


Met Asp Phe Ser Thr Glu Ser Leu Gln Pro Ile Trp Ala Leu Ala Asp 
        275                 280                 285             


Lys Pro Glu Arg Arg Val Glu Leu Glu Asp Ala Phe Pro Glu Phe Met 
    290                 295                 300                 


Lys Gln Ser Gln Gln Ser Ile Pro Lys Val Asp Lys Val Leu Leu Met 
305                 310                 315                 320 


Asp Ala Arg Pro Pro Met Val Lys Ala Gly Glu Asp Ser Gly Ser Gly 
                325                 330                 335     


Ala Ser Glu Asp Leu Ala Val Phe Asn Pro Ser Thr Ser Asn Gly Tyr 
            340                 345                 350         


Lys Met Val Gly Gln Phe Gly Gln Arg Asn His Ala Ser Val Ala Asp 
        355                 360                 365             


Gly His Ala Pro Ile Phe Lys Asp Leu Phe Asp Leu Gly Val Leu Lys 
    370                 375                 380                 


Ala Pro Val Gly Trp Gln Arg Val Trp Asp Asp Ala Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Lys Asp Tyr Ala Cys Trp Arg Ala Ile Pro Pro Gln Gly Tyr Arg 
                405                 410                 415     


Ala Leu Gly Asp Val Met Met Leu Ala Thr Ser Gly Tyr Asn Pro Pro 
            420                 425                 430         


Asn Leu Pro Asp Tyr Val Cys Val His Gln Ser Leu Cys Ala Asp Val 
        435                 440                 445             


Gln Thr Leu Gln Asn Arg Val Trp Trp Asp Lys Gly Thr Gly Ala Arg 
    450                 455                 460                 


Lys Asp Leu Ser Leu Trp Gln Pro Gly Ala Ala Gly Ala Val Ala Ser 
465                 470                 475                 480 


Ser Cys Phe Ala Gly Val Pro Asn Tyr Asn Asn Pro Pro Asn Ser Gly 
                485                 490                 495     


Asp Ile Glu Arg Leu Arg Gly Ser Ile Ala Cys Val Lys Thr Ser Ala 
            500                 505                 510         


Ile Ala Ser Met Gln Glu Met Lys Ser Met Leu Ser Gln His Gln Gly 
        515                 520                 525             


Met Glu Ala Met Met Ser Lys Leu 
    530                 535     


<210>  8
<211>  536
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Axmi205(evo34) mutant

<400>  8

Met Ala Ser Ala Ala Asn Ala Gly Gln Leu Gly Asn Leu Pro Gly Val 
1               5                   10                  15      


Thr Ser Met Gly Met Gly Tyr Asp Val Asn Gly Leu Tyr Ala Ser Pro 
            20                  25                  30          


Glu Ser Leu Leu Gly Gln Pro Leu Phe Asp Phe Gly Gly Glu Leu Asp 
        35                  40                  45              


Ser Ile Glu Ile Glu Gly Arg Ser Tyr Thr Phe Pro Arg Ser Met His 
    50                  55                  60                  


Val His Thr Tyr Phe His Ser Asp Phe Lys Gln Asp Val Ser Lys Glu 
65                  70                  75                  80  


Ile Glu Glu Tyr Arg Thr Lys Met Ser Gln His Val Gly Val Ser Gly 
                85                  90                  95      


Arg Tyr Lys Leu Phe Ser Ala Ser Leu Ser Val Asp Phe Thr Thr Thr 
            100                 105                 110         


Asp Gln Gln Leu Thr Glu Ile Thr Tyr Ser Ser Thr Arg Glu Ala His 
        115                 120                 125             


Val Leu Trp Tyr Ile Ser Leu Pro Gly Ala Ala Thr Leu Arg Ser Met 
    130                 135                 140                 


Leu Arg Arg Asp Phe Arg Asp Asp Leu Asn Asn Pro Asn Met Pro Ala 
145                 150                 155                 160 


Met Glu Leu Phe Lys Arg Tyr Gly Pro Tyr Tyr Ile Ser Glu Ala Ala 
                165                 170                 175     


Val Gly Gly Arg Leu Asp Tyr Ser Ala Ala Ser Lys Thr Leu Lys Met 
            180                 185                 190         


Asp Ser Ser Gln Ser Leu Ser Thr Thr Ala Glu Met Ser Tyr Lys Ala 
        195                 200                 205             


Leu Val Gly Glu Ile Lys Ile Glu His Gly Ser Glu Met Glu Lys Gln 
    210                 215                 220                 


Val Asn Ser Phe Arg Ser Asn Ser Thr Ile Arg Leu Thr Ala Thr Gly 
225                 230                 235                 240 


Gly Lys Pro Gly Met Thr Asp Arg Ile Leu His Gly Pro Asp Ser Gln 
                245                 250                 255     


Gln Ala Phe Ser Gln Trp Ala Glu Ser Leu Leu Asp Tyr Ala Thr Leu 
            260                 265                 270         


Met Asp Phe Ser Thr Glu Ser Leu Gln Pro Ile Trp Ala Leu Ala Asp 
        275                 280                 285             


Lys Pro Glu Arg Arg Val Glu Leu Glu Asp Ala Phe Pro Glu Phe Met 
    290                 295                 300                 


Lys Gln Ser Gln Gln Ser Ile Pro Lys Val Asp Lys Val Leu Leu Met 
305                 310                 315                 320 


Asp Ala Arg Pro Pro Met Val Lys Ala Gly Glu Asp Ser Gly Ser Gly 
                325                 330                 335     


Ala Ser Glu Asp Leu Ala Val Phe Asn Pro Ser Thr Ser Asn Gly Tyr 
            340                 345                 350         


Lys Met Val Gly Gln Phe Gly Gln Arg Asn His Ala Ser Val Ala Asp 
        355                 360                 365             


Gly His Ala Pro Ile Phe Lys Asp Leu Phe Asp Leu Gly Val Leu Lys 
    370                 375                 380                 


Ala Pro Val Gly Trp Gln Arg Val Trp Asp Asp Ala Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Lys Asp Tyr Ala Cys Trp Arg Ala Ile Pro Pro Gln Gly Tyr Arg 
                405                 410                 415     


Ala Leu Gly Asp Val Met Met Leu Ala Thr Ser Gly Tyr Asn Pro Pro 
            420                 425                 430         


Asn Leu Pro Asp Tyr Val Cys Val His Gln Ser Leu Cys Ala Asp Val 
        435                 440                 445             


Gln Thr Leu Gln Asn Arg Val Trp Trp Asp Lys Gly Thr Gly Ala Arg 
    450                 455                 460                 


Lys Asp Val Ser Leu Trp Gln Pro Gly Ala Ala Gly Ala Val Ala Ser 
465                 470                 475                 480 


Ser Cys Phe Ala Gly Val Pro Asn Tyr Asn Asn Pro Pro Asn Ser Gly 
                485                 490                 495     


Asp Ile Glu Arg Leu Arg Gly Ser Ile Ala Cys Val Lys Thr Ser Ala 
            500                 505                 510         


Ile Ala Ser Met Gln Glu Met Lys Ser Met Leu Ser Gln His Gln Gly 
        515                 520                 525             


Met Glu Ala Met Met Ser Lys Leu 
    530                 535     


<210>  9
<211>  536
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Axmi205(evo35)

<400>  9

Met Ala Ser Ala Ala Asn Ala Gly Gln Leu Gly Asn Leu Pro Gly Val 
1               5                   10                  15      


Thr Ser Met Gly Met Gly Tyr Asp Val Asn Gly Leu Tyr Ala Ser Pro 
            20                  25                  30          


Glu Ser Leu Leu Gly Gln Pro Leu Phe Asp Phe Gly Gly Glu Leu Asp 
        35                  40                  45              


Ser Ile Glu Ile Glu Gly Arg Ser Tyr Thr Phe Pro Arg Ser Met His 
    50                  55                  60                  


Val His Thr Tyr Phe His Ser Asp Phe Lys Gln Asp Val Ser Lys Glu 
65                  70                  75                  80  


Ile Glu Glu Tyr Arg Glu Lys Met Ser Gln His Val Gly Val Ser Gly 
                85                  90                  95      


Arg Tyr Lys Leu Phe Ser Ala Ser Leu Ser Val Asp Phe Thr Thr Thr 
            100                 105                 110         


Asp Gln Gln Leu Thr Glu Ile Thr Tyr Ser Ser Thr Arg Glu Ala His 
        115                 120                 125             


Val Leu Trp Tyr Ile Ser Leu Pro Gly Ala Ala Thr Leu Arg Ser Met 
    130                 135                 140                 


Leu Arg Arg Asp Phe Arg Asp Asp Leu Asn Asn Pro Asn Met Pro Ala 
145                 150                 155                 160 


Met Glu Leu Phe Lys Arg Tyr Gly Pro Tyr Tyr Ile Ser Glu Ala Ala 
                165                 170                 175     


Val Gly Gly Arg Leu Asp Tyr Ser Ala Ala Ser Lys Thr Leu Lys Met 
            180                 185                 190         


Asp Ser Ser Gln Ser Leu Ser Thr Thr Ala Glu Met Ser Tyr Lys Ala 
        195                 200                 205             


Leu Val Gly Glu Ile Lys Ile Glu His Gly Ser Glu Met Glu Lys Gln 
    210                 215                 220                 


Val Asn Ser Phe Arg Ser Asn Ser Thr Ile Arg Leu Thr Ala Thr Gly 
225                 230                 235                 240 


Gly Lys Pro Gly Met Thr Asp Arg Ile Leu His Gly Pro Asp Ser Gln 
                245                 250                 255     


Gln Ala Phe Ser Gln Trp Ala Glu Ser Leu Leu Asp Tyr Ala Thr Leu 
            260                 265                 270         


Met Asp Phe Ser Thr Glu Ser Leu Gln Pro Ile Trp Ala Leu Ala Asp 
        275                 280                 285             


Lys Pro Glu Arg Arg Val Glu Leu Glu Asp Ala Phe Pro Glu Phe Met 
    290                 295                 300                 


Lys Gln Ser Gln Gln Ser Ile Pro Lys Val Asp Lys Val Leu Leu Met 
305                 310                 315                 320 


Asp Ala Arg Pro Pro Met Val Lys Ala Gly Glu Asp Ser Gly Ser Gly 
                325                 330                 335     


Ala Ser Glu Asp Leu Ala Val Phe Asn Pro Ser Thr Ser Asn Gly Tyr 
            340                 345                 350         


Lys Met Val Gly Gln Phe Gly Gln Arg Asn His Ala Ser Val Ala Asp 
        355                 360                 365             


Gly His Ala Pro Ile Phe Lys Asp Leu Phe Asp Leu Gly Val Leu Lys 
    370                 375                 380                 


Ala Pro Val Gly Trp Gln Arg Val Trp Asp Asp Ala Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Lys Asp Tyr Ala Cys Trp Arg Ala Ile Pro Pro Gln Gly Tyr Arg 
                405                 410                 415     


Ala Leu Gly Asp Val Met Met Leu Ala Thr Ser Gly Tyr Asn Pro Pro 
            420                 425                 430         


Asn Leu Pro Asp Tyr Val Cys Val His Gln Ser Leu Cys Ala Asp Val 
        435                 440                 445             


Gln Thr Leu Gln Asn Arg Val Trp Trp Asp Lys Gly Thr Gly Ala Arg 
    450                 455                 460                 


Lys Asp Val Ser Leu Trp Gln Pro Gly Ala Ala Gly Ala Val Ala Ser 
465                 470                 475                 480 


Ser Cys Phe Ala Gly Val Pro Asn Tyr Asn Asn Pro Pro Asn Ser Gly 
                485                 490                 495     


Asp Ile Glu Arg Leu Arg Gly Ser Ile Ala Cys Val Lys Thr Ser Ala 
            500                 505                 510         


Ile Ala Ser Met Arg Glu Met Lys Ser Met Leu Ser Gln His Gln Gly 
        515                 520                 525             


Met Glu Ala Met Met Ser Lys Leu 
    530                 535     


<210>  10
<211>  536
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Axmi205 (PMlib1 Pool 1G2_p2a11) mutant

<400>  10

Met Ala Ser Ala Ala Asn Ala Gly Gln Leu Gly Asn Leu Pro Gly Val 
1               5                   10                  15      


Thr Ser Met Gly Met Gly Tyr Asp Val Asn Gly Leu Tyr Ala Ser Pro 
            20                  25                  30          


Glu Ser Leu Leu Gly Gln Pro Leu Phe Asp Phe Gly Gly Glu Leu Asp 
        35                  40                  45              


Ser Ile Glu Ile Glu Gly Arg Ser Tyr Thr Phe Pro Arg Ser Met His 
    50                  55                  60                  


Val His Thr Tyr Phe His Ser Asp Phe Lys Gln Asp Val Ser Lys Glu 
65                  70                  75                  80  


Ile Glu Glu Tyr Arg Glu Lys Met Ser Gln His Val Gly Val Ser Gly 
                85                  90                  95      


Arg Tyr Lys Leu Phe Ser Ala Ser Leu Ser Val Asp Phe Thr Thr Thr 
            100                 105                 110         


Asp Gln Gln Leu Thr Glu Ile Thr Tyr Ser Ser Thr Arg Glu Ala His 
        115                 120                 125             


Val Leu Trp Tyr Ile Ser Leu Pro Gly Ala Ala Thr Leu Arg Ser Met 
    130                 135                 140                 


Leu Arg Arg Asp Phe Arg Asp Asp Leu Asn Asn Pro Asn Met Pro Ala 
145                 150                 155                 160 


Met Glu Leu Phe Lys Arg Tyr Gly Pro Tyr Tyr Ile Ser Glu Ala Ala 
                165                 170                 175     


Val Gly Gly Arg Leu Asp Tyr Ser Ala Ala Ser Lys Thr Leu Lys Met 
            180                 185                 190         


Asp Ser Ser Gln Ser Leu Ser Thr Thr Ala Glu Met Ser Tyr Lys Ala 
        195                 200                 205             


Leu Val Gly Glu Ile Lys Ile Glu His Gly Ser Glu Met Glu Lys Gln 
    210                 215                 220                 


Val Asn Ser Phe Arg Ser Asn Ser Thr Ile Arg Leu Thr Ala Thr Gly 
225                 230                 235                 240 


Gly Lys Pro Gly Met Thr Asp Arg Ile Leu His Gly Pro Asp Ser Gln 
                245                 250                 255     


Gln Ala Phe Ser Gln Trp Ala Glu Ser Leu Leu Asp Tyr Ala Thr Leu 
            260                 265                 270         


Met Asp Phe Ser Thr Glu Ser Leu Gln Pro Ile Trp Ala Leu Ala Asp 
        275                 280                 285             


Lys Pro Glu Arg Arg Val Glu Leu Glu Asp Ala Phe Pro Glu Phe Met 
    290                 295                 300                 


Lys Gln Ser Gln Gln Ser Ile Pro Lys Val Asp Lys Val Leu Leu Met 
305                 310                 315                 320 


Asp Ala Arg Pro Pro Met Val Lys Ala Gly Glu Asp Ser Gly Ser Gly 
                325                 330                 335     


Ala Ser Glu Asp Leu Ala Val Phe Asn Pro Ser Thr Ser Asn Gly Tyr 
            340                 345                 350         


Lys Met Val Gly Gln Phe Gly Gln Arg Asn His Ala Ser Val Ala Asp 
        355                 360                 365             


Gly His Ala Pro Ile Phe Lys Asp Leu Phe Asp Leu Gly Val Leu Lys 
    370                 375                 380                 


Ala Pro Val Gly Trp Gln Arg Val Trp Asp Asp Ala Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Lys Asp Tyr Ala Cys Trp Arg Ala Ile Pro Pro Gln Gly Tyr Arg 
                405                 410                 415     


Ala Leu Gly Asp Val Met Met Leu Ala Thr Ser Gly Tyr Asn Pro Pro 
            420                 425                 430         


Asn Leu Pro Asp Tyr Val Cys Val His Gln Ser Leu Cys Ala Asp Val 
        435                 440                 445             


Gln Thr Leu Gln Asn Arg Val Trp Trp Asp Lys Gly Thr Gly Ala Arg 
    450                 455                 460                 


Lys Asp Val Ser Leu Trp Gln Pro Gly Ala Ala Gly Ala Val Ala Ser 
465                 470                 475                 480 


Ser Cys Phe Ala Gly Val Pro Asn Tyr Asn Asn Pro Pro Asn Ser Gly 
                485                 490                 495     


Asp Ile Glu Arg Leu Arg Gly Ser Ile Ala Cys Val Lys Thr Ser Ala 
            500                 505                 510         


Ile Ala Ser Met Gln Glu Met Lys Ser Met Leu Ser Gln His Gln Gly 
        515                 520                 525             


Met Glu Ala Met Met Ser Lys Leu 
    530                 535     


<210>  11
<211>  536
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Axmi205 PMlib1 Pool 1G2_p1c1 mutant

<400>  11

Met Ala Ser Ala Ala Asn Ala Gly Gln Leu Gly Asn Leu Pro Gly Val 
1               5                   10                  15      


Thr Ser Met Gly Met Gly Tyr Asp Val Asn Gly Leu Tyr Ala Ser Pro 
            20                  25                  30          


Glu Ser Leu Leu Gly Gln Pro Leu Phe Asp Phe Gly Gly Glu Leu Asp 
        35                  40                  45              


Ser Ile Glu Ile Glu Gly Arg Ser Tyr Thr Phe Pro Arg Ser Met His 
    50                  55                  60                  


Val His Thr Tyr Phe His Ser Asp Phe Lys Gln Asp Val Ser Lys Glu 
65                  70                  75                  80  


Ile Glu Glu Tyr Arg Glu Lys Met Ser Gln His Val Gly Val Ser Gly 
                85                  90                  95      


Arg Tyr Lys Leu Phe Ser Ala Ser Leu Ser Val Asp Phe Thr Thr Thr 
            100                 105                 110         


Asp Gln Gln Leu Thr Glu Ile Thr Tyr Ser Ser Thr Arg Glu Ala His 
        115                 120                 125             


Val Leu Trp Tyr Ile Ser Leu Pro Gly Ala Ala Thr Leu Arg Ser Met 
    130                 135                 140                 


Leu Arg Arg Asp Phe Arg Asp Asp Leu Asn Asn Pro Asn Met Pro Ala 
145                 150                 155                 160 


Met Glu Leu Phe Lys Arg Tyr Gly Pro Tyr Tyr Ile Ser Glu Ala Ala 
                165                 170                 175     


Val Gly Gly Arg Leu Asp Tyr Ser Ala Ala Ser Lys Thr Leu Lys Met 
            180                 185                 190         


Asp Ser Ser Gln Ser Leu Ser Thr Thr Ala Glu Met Ser Tyr Lys Ala 
        195                 200                 205             


Leu Val Gly Glu Ile Lys Ile Glu His Gly Ser Glu Met Glu Lys Gln 
    210                 215                 220                 


Val Asn Ser Phe Arg Ser Asn Ser Thr Ile Arg Leu Thr Ala Thr Gly 
225                 230                 235                 240 


Gly Lys Pro Gly Met Thr Asp Arg Ile Leu His Gly Pro Asp Ser Gln 
                245                 250                 255     


Gln Ala Phe Ser Gln Trp Ala Glu Ser Leu Leu Asp Tyr Ala Thr Leu 
            260                 265                 270         


Met Asp Phe Ser Thr Glu Ser Leu Gln Pro Ile Trp Ala Leu Ala Asp 
        275                 280                 285             


Lys Pro Glu Arg Arg Val Glu Leu Glu Asp Ala Phe Pro Glu Phe Met 
    290                 295                 300                 


Lys Gln Ser Gln Gln Ser Ile Pro Lys Val Asp Lys Val Leu Leu Met 
305                 310                 315                 320 


Asp Ala Arg Pro Pro Met Val Lys Ala Gly Glu Asp Ser Gly Ser Gly 
                325                 330                 335     


Ala Ser Glu Asp Leu Ala Val Phe Asn Pro Ser Thr Ser Asn Gly Tyr 
            340                 345                 350         


Lys Met Val Gly Gln Phe Gly Gln Arg Asn His Ala Ser Val Ala Asp 
        355                 360                 365             


Gly His Ala Pro Ile Phe Lys Asp Leu Phe Asp Leu Gly Val Leu Lys 
    370                 375                 380                 


Ala Pro Val Gly Trp Gln Arg Val Trp Asp Asp Ala Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Lys Asp Tyr Ala Cys Trp Arg Ala Ile Pro Pro Gln Gly Tyr Arg 
                405                 410                 415     


Ala Leu Gly Asp Val Met Met Leu Ala Thr Ser Gly Tyr Asn Pro Pro 
            420                 425                 430         


Asn Leu Pro Asp Tyr Val Cys Val His Gln Ser Leu Cys Ala Asp Val 
        435                 440                 445             


Gln Thr Leu Gln Asn Arg Val Trp Trp Asp Lys Gly Thr Gly Ala Arg 
    450                 455                 460                 


Lys Asp Thr Ser Leu Trp Gln Pro Gly Ala Ala Gly Ala Val Ala Ser 
465                 470                 475                 480 


Ser Cys Phe Ala Gly Val Pro Asn Tyr Asn Asn Pro Pro Asn Ser Gly 
                485                 490                 495     


Asp Ile Glu Arg Leu Arg Gly Ser Ile Ala Cys Val Lys Thr Ser Ala 
            500                 505                 510         


Ile Ala Ser Met Gln Glu Met Lys Ser Met Leu Ser Gln His Gln Gly 
        515                 520                 525             


Met Glu Ala Met Met Ser Lys Leu 
    530                 535     


<210>  12
<211>  536
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Axmi205 PMlib1 Pool 1G2_p1a4

<400>  12

Met Ala Ser Ala Ala Asn Ala Gly Gln Leu Gly Asn Leu Pro Gly Val 
1               5                   10                  15      


Thr Ser Met Gly Met Gly Tyr Asp Val Asn Gly Leu Tyr Ala Ser Pro 
            20                  25                  30          


Glu Ser Leu Leu Gly Gln Pro Leu Phe Asp Phe Gly Gly Glu Leu Asp 
        35                  40                  45              


Ser Ile Glu Ile Glu Gly Arg Ser Tyr Thr Phe Pro Arg Ser Met His 
    50                  55                  60                  


Val His Thr Tyr Phe His Ser Asp Phe Lys Gln Asp Val Ser Lys Glu 
65                  70                  75                  80  


Ile Glu Glu Tyr Arg Glu Lys Met Ser Gln His Val Gly Val Ser Gly 
                85                  90                  95      


Arg Tyr Lys Leu Phe Ser Ala Ser Leu Ser Val Asp Phe Thr Thr Thr 
            100                 105                 110         


Asp Gln Gln Leu Thr Glu Ile Thr Tyr Ser Ser Thr Arg Glu Ala His 
        115                 120                 125             


Val Leu Trp Tyr Ile Ser Leu Pro Gly Ala Ala Thr Leu Arg Ser Met 
    130                 135                 140                 


Leu Arg Arg Asp Phe Arg Asp Asp Leu Asn Asn Pro Asn Met Pro Ala 
145                 150                 155                 160 


Met Glu Leu Phe Lys Arg Tyr Gly Pro Tyr Tyr Ile Ser Glu Ala Ala 
                165                 170                 175     


Val Gly Gly Arg Leu Asp Tyr Ser Ala Ala Ser Lys Thr Leu Lys Met 
            180                 185                 190         


Asp Ser Ser Gln Ser Leu Ser Thr Thr Ala Glu Met Ser Tyr Lys Ala 
        195                 200                 205             


Leu Val Gly Glu Ile Lys Ile Glu His Gly Ser Glu Met Glu Lys Gln 
    210                 215                 220                 


Val Asn Ser Phe Arg Ser Asn Ser Thr Ile Arg Leu Thr Ala Thr Gly 
225                 230                 235                 240 


Gly Lys Pro Gly Met Thr Asp Arg Ile Leu His Gly Pro Asp Ser Gln 
                245                 250                 255     


Gln Ala Phe Ser Gln Trp Ala Glu Ser Leu Leu Asp Tyr Ala Thr Leu 
            260                 265                 270         


Met Asp Phe Ser Thr Glu Ser Leu Gln Pro Ile Trp Ala Leu Ala Asp 
        275                 280                 285             


Lys Pro Glu Arg Arg Val Glu Leu Glu Asp Ala Phe Pro Glu Phe Met 
    290                 295                 300                 


Lys Gln Ser Gln Gln Ser Ile Pro Lys Val Asp Lys Val Leu Leu Met 
305                 310                 315                 320 


Asp Ala Arg Pro Pro Met Val Lys Ala Gly Glu Asp Ser Gly Ser Gly 
                325                 330                 335     


Ala Ser Glu Asp Leu Ala Val Phe Asn Pro Ser Thr Ser Asn Gly Tyr 
            340                 345                 350         


Lys Met Val Gly Gln Phe Gly Gln Arg Asn His Ala Ser Val Ala Asp 
        355                 360                 365             


Gly His Ala Pro Ile Phe Lys Asp Leu Phe Asp Leu Gly Val Leu Lys 
    370                 375                 380                 


Ala Pro Val Gly Trp Gln Arg Val Trp Asp Asp Ala Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Lys Asp Tyr Ala Cys Trp Arg Ala Ile Pro Pro Gln Gly Tyr Arg 
                405                 410                 415     


Ala Leu Gly Asp Val Met Met Leu Ala Thr Ser Gly Tyr Asn Pro Pro 
            420                 425                 430         


Asn Leu Pro Asp Tyr Val Cys Val His Gln Ser Leu Cys Ala Asp Val 
        435                 440                 445             


Gln Thr Leu Gln Asn Arg Val Trp Trp Asp Lys Gly Thr Gly Ala Asn 
    450                 455                 460                 


Lys Asp Val Ser Leu Trp Gln Pro Gly Ala Ala Gly Ala Val Ala Ser 
465                 470                 475                 480 


Ser Cys Phe Ala Gly Val Pro Asn Tyr Asn Asn Pro Pro Asn Ser Gly 
                485                 490                 495     


Asp Ile Glu Arg Leu Arg Gly Ser Ile Ala Cys Val Lys Thr Ser Ala 
            500                 505                 510         


Ile Ala Ser Met Gln Glu Met Lys Ser Met Leu Ser Gln His Gln Gly 
        515                 520                 525             


Met Glu Ala Met Met Ser Lys Leu 
    530                 535     


<210>  13
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  endoplasmic reticulum targeting peptide

<400>  13

Lys Asp Glu Leu 
1               


