                               SEQUENCE LISTING

<110> CALIFORNIA INSTITUTE OF TECHNOLOGY 
      THE ROCKEFELLER UNIVERSITY
 
<120> COMPOSITIONS AND METHODS FOR IMPROVING POTENCY AND BREADTH OF HIV
      ANTIBODIES

<130> C766 69598.WO

<140>
<141>

<150> 61/523,244
<151> 2011-08-12

<150> 61/511,425
<151> 2011-07-25

<160> 46    

<170> PatentIn version 3.5

<210> 1
<211> 104
<212> PRT
<213> Homo sapiens

<400> 1
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210> 2
<211> 49
<212> PRT
<213> Homo sapiens

<400> 2
Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly 
    


<210> 3
<211> 104
<212> PRT
<213> Homo sapiens

<400> 3
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Arg Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Leu Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210> 4
<211> 121
<212> PRT
<213> Homo sapiens

<400> 4
Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Gln Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Val Arg Leu Ala Pro Gly Arg Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210> 5
<211> 107
<212> PRT
<213> Homo sapiens

<400> 5
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Ser Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Ala Asp Tyr Asn Leu Ser Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg Thr Val Ala 
            100                 105         


<210> 6
<211> 125
<212> PRT
<213> Homo sapiens

<400> 6
Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Leu Ser Cys Arg Ala Ser Gly Tyr Glu Phe Leu Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Arg Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Asp Phe 
            100                 105                 110         


Glu His Trp Gly Arg Gly Ala Pro Val Thr Val Ser Ser 
        115                 120                 125 


<210> 7
<211> 103
<212> PRT
<213> Homo sapiens

<400> 7
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ala Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Val Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Ile Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala 
            100             


<210> 8
<211> 123
<212> PRT
<213> Homo sapiens

<400> 8
Gln Val His Leu Ser Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Lys Ile Ser Asp His 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg Gln Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Tyr Ser Phe Tyr Met Asp Leu Lys Ala Val Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Ile Tyr Phe Cys Ala Arg Gln Arg Ser Asp Phe Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210> 9
<211> 103
<212> PRT
<213> Homo sapiens

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Ile Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Val Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala 
            100             


<210> 10
<211> 123
<212> PRT
<213> Homo sapiens

<400> 10
Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210> 11
<211> 103
<212> PRT
<213> Homo sapiens

<400> 11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Thr Gly Val Pro Ser Arg Phe Thr Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Ile Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Ile Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala 
            100             


<210> 12
<211> 123
<212> PRT
<213> Homo sapiens

<400> 12
Gln Val Arg Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Glu Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg Gln Ala Ser Trp Asp Phe Asp Ser 
65                  70                  75                  80  


Tyr Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp Asp Thr Gly 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210> 13
<211> 103
<212> PRT
<213> Homo sapiens

<400> 13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Ile Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Ile Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala 
            100             


<210> 14
<211> 123
<212> PRT
<213> Homo sapiens

<400> 14
Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Leu Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Phe Ser Phe Tyr Met Asp Leu Lys Ala Val Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210> 15
<211> 103
<212> PRT
<213> Homo sapiens

<400> 15
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Ala Glu Asp Ile Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Ala Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala 
            100             


<210> 16
<211> 123
<212> PRT
<213> Homo sapiens

<400> 16
Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Phe Ser Phe Tyr Met Asp Leu Lys Gly Leu Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Ile Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210> 17
<211> 107
<212> PRT
<213> Homo sapiens

<400> 17
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Gly Gln Gly Ile Gly Ser Ser 
            20                  25                  30          


Leu Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


His Gly Ala Ser Asn Leu His Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Thr Phe Ser Leu Thr Ile Ser Gly Leu Gln Arg 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Phe Cys Ala Val Leu Glu Phe Phe Gly Pro 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105         


<210> 18
<211> 122
<212> PRT
<213> Homo sapiens

<400> 18
Ser Gln His Leu Val Gln Ser Gly Thr Gln Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Gln Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Val Leu His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Val Tyr Gly Ala Arg Asn Tyr Ala Arg Arg Phe 
    50                  55                  60                  


Gln Gly Arg Ile Asn Phe Asp Arg Asp Ile Tyr Arg Glu Ile Ala Phe 
65                  70                  75                  80  


Met Asp Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Gly Asp Asp Thr Ser Trp His Leu Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Ile Val Ser Ala 
        115                 120         


<210> 19
<211> 102
<212> PRT
<213> Homo sapiens

<400> 19
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Leu Ser Cys Thr Ala Ala Ser Tyr Gly His Met Thr 
            20                  25                  30          


Trp Tyr Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Ala 
        35                  40                  45              


Thr Ser Lys Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gln 
    50                  55                  60                  


Phe Gly Lys Gln Tyr Thr Leu Thr Ile Thr Arg Met Glu Pro Glu Asp 
65                  70                  75                  80  


Phe Ala Arg Tyr Tyr Cys Gln Gln Leu Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Arg Leu Glu Ile Arg Arg 
            100         


<210> 20
<211> 125
<212> PRT
<213> Homo sapiens

<400> 20
Gln Val Gln Leu Val Gln Ser Gly Ser Gly Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Trp Thr Ser Glu Asp Ile Phe Glu Arg Thr 
            20                  25                  30          


Glu Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Val Lys Thr Val Thr Gly Ala Val Asn Phe Gly Ser Pro 
    50                  55                  60                  


Asp Phe Arg Gln Arg Val Ser Leu Thr Arg Asp Arg Asp Leu Phe Thr 
65                  70                  75                  80  


Ala His Met Asp Ile Arg Gly Leu Thr Gln Gly Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Gln Lys Phe Tyr Thr Gly Gly Gln Gly Trp Tyr Phe 
            100                 105                 110         


Asp Leu Trp Gly Arg Gly Thr Leu Ile Val Val Ser Ser 
        115                 120                 125 


<210> 21
<211> 103
<212> PRT
<213> Homo sapiens

<400> 21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Arg Gly Ile Gly Lys Asp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Ser Asp Ala Ser Ile Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Gln Asn Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Glu Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys 
            100             


<210> 22
<211> 131
<212> PRT
<213> Homo sapiens

<400> 22
Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Phe Ala Glu Asp Asp Asp Tyr Ser Pro 
            20                  25                  30          


His Trp Val Asn Pro Ala Pro Glu His Tyr Ile His Phe Leu Arg Gln 
        35                  40                  45              


Ala Pro Gly Gln Gln Leu Glu Trp Leu Ala Trp Met Asn Pro Thr Asn 
    50                  55                  60                  


Gly Ala Val Asn Tyr Ala Trp Gln Leu His Gly Arg Leu Thr Ala Thr 
65                  70                  75                  80  


Arg Asp Gly Ser Met Thr Thr Ala Phe Leu Glu Val Arg Ser Leu Arg 
                85                  90                  95      


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gln Lys Arg Gly 
            100                 105                 110         


Arg Ser Glu Trp Ala Tyr Ala His Trp Gly Gln Gly Thr Pro Val Leu 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 23
<211> 103
<212> PRT
<213> Homo sapiens

<400> 23
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Arg Gly Ile Gly Lys Asp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Ser Asp Ala Ser Thr Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Gln Asn Phe Ser Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Glu Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys 
            100             


<210> 24
<211> 131
<212> PRT
<213> Homo sapiens

<400> 24
Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Phe Ala Glu Asp Asp Asp Tyr Ser Pro 
            20                  25                  30          


Tyr Trp Val Asn Pro Ala Pro Glu His Phe Ile His Phe Leu Arg Gln 
        35                  40                  45              


Ala Pro Gly Gln Gln Leu Glu Trp Leu Ala Trp Met Asn Pro Thr Asn 
    50                  55                  60                  


Gly Ala Val Asn Tyr Ala Trp Tyr Leu Asn Gly Arg Val Thr Ala Thr 
65                  70                  75                  80  


Arg Asp Arg Ser Met Thr Thr Ala Phe Leu Glu Val Lys Ser Leu Arg 
                85                  90                  95      


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gln Lys Arg Gly 
            100                 105                 110         


Arg Ser Glu Trp Ala Tyr Ala His Trp Gly Gln Gly Thr Pro Val Val 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 25
<211> 103
<212> PRT
<213> Homo sapiens

<400> 25
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Arg Gly Ile Gly Lys Asp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Ser Asp Ala Ser Ile Leu Glu Gly Gly Val Pro Thr Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Gln Asn Phe Ser Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Glu Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys 
            100             


<210> 26
<211> 131
<212> PRT
<213> Homo sapiens

<400> 26
Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Phe Ala Glu Asp Asp Asp Phe Ser Pro 
            20                  25                  30          


His Trp Val Asn Pro Ala Pro Glu His Tyr Ile His Phe Leu Arg Gln 
        35                  40                  45              


Ala Pro Gly Gln Gln Leu Glu Trp Leu Ala Trp Met Lys Pro Thr Asn 
    50                  55                  60                  


Gly Ala Val Asn Tyr Ala Trp Gln Leu Gln Gly Arg Val Thr Val Thr 
65                  70                  75                  80  


Arg Asp Arg Ser Gln Thr Thr Ala Phe Leu Glu Val Lys Asn Leu Arg 
                85                  90                  95      


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gln Lys Arg Gly 
            100                 105                 110         


Arg Ser Glu Trp Ala Tyr Ala His Trp Gly Gln Gly Thr Pro Val Val 
        115                 120                 125             


Ile Ser Ala 
    130     


<210> 27
<211> 103
<212> PRT
<213> Homo sapiens

<400> 27
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Arg Gly Ile Gly Lys Asp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Arg Gly Arg Ala Pro Arg Leu Leu Val 
        35                  40                  45              


Ser Asp Ala Ser Val Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Gln Asn Phe Ser Leu Thr Ile Ser Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Glu Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys 
            100             


<210> 28
<211> 131
<212> PRT
<213> Homo sapiens

<400> 28
Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Ile Ser Val Ser Cys Lys Phe Ala Asp Ala Asp Asp Tyr Ser Pro 
            20                  25                  30          


His Trp Met Asn Pro Ala Pro Glu His Tyr Ile His Phe Leu Arg Gln 
        35                  40                  45              


Ala Pro Gly Gln Gln Leu Glu Trp Leu Ala Trp Met Asn Pro Thr Asn 
    50                  55                  60                  


Gly Ala Val Asn Tyr Ala Trp Tyr Leu Asn Gly Arg Val Thr Ala Thr 
65                  70                  75                  80  


Arg Asp Arg Ser Met Thr Thr Ala Phe Leu Glu Val Arg Ser Leu Arg 
                85                  90                  95      


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gln Lys Arg Ala 
            100                 105                 110         


Arg Ser Glu Trp Ala Tyr Ala His Trp Gly Gln Gly Thr Pro Val Val 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 29
<211> 103
<212> PRT
<213> Homo sapiens

<400> 29
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Arg Gly Ile Gly Lys Asp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Ser Asp Ala Ser Ile Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Gln Asn Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Glu Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys 
            100             


<210> 30
<211> 131
<212> PRT
<213> Homo sapiens

<400> 30
Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Phe Ala Glu Asp Asp Asp Trp Ser Pro 
            20                  25                  30          


His Trp Val Asn Pro Ala Pro Glu His Tyr Ile His Phe Leu Arg Gln 
        35                  40                  45              


Ala Pro Gly Gln Gln Leu Glu Trp Leu Ala Trp Met Asn Pro Thr Asn 
    50                  55                  60                  


Gly Ala Val Asn Tyr Ala Trp Gln Leu Asn Gly Arg Leu Thr Ala Thr 
65                  70                  75                  80  


Arg Asp Thr Ser Met Thr Thr Ala Phe Leu Glu Val Lys Ser Leu Arg 
                85                  90                  95      


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gln Lys Arg Gly 
            100                 105                 110         


Arg Ser Glu Trp Ala Tyr Ala His Trp Gly Gln Gly Thr Pro Val Val 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 31
<211> 103
<212> PRT
<213> Homo sapiens

<400> 31
Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Phe Cys Lys Ala Ser Gln Gly Gly Asn Ala Met 
            20                  25                  30          


Thr Trp Tyr Gln Lys Arg Arg Gly Gln Val Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Arg Arg Ala Ser Gly Val Pro Asp Arg Phe Val Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Phe Leu Thr Ile Asn Lys Leu Asp Arg Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Glu Phe Phe Gly Leu Gly 
                85                  90                  95      


Ser Glu Leu Glu Val His Arg 
            100             


<210> 32
<211> 130
<212> PRT
<213> Homo sapiens

<400> 32
Gln Val Gln Leu Val Gln Ser Gly Ala Val Ile Lys Thr Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Asn Phe Arg Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Leu Ile Pro Asp Lys Gly Phe Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Trp Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Val Ala Tyr Met Glu Phe Ser Gly Leu Thr Pro Ala 
                85                  90                  95      


Asp Thr Ala Glu Tyr Phe Cys Val Arg Arg Gly Ser Cys Asp Tyr Cys 
            100                 105                 110         


Gly Asp Phe Pro Trp Gln Tyr Trp Gly Gln Gly Thr Val Val Val Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 33
<211> 104
<212> PRT
<213> Homo sapiens

<400> 33
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Thr Ser Ala Gly Tyr Leu Asn Trp 
            20                  25                  30          


Tyr Gln Gln Arg Arg Gly Arg Ala Pro Lys Leu Leu Met Tyr Asp Gly 
        35                  40                  45              


Ser Arg Leu Val Thr Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp 
    50                  55                  60                  


Gly Thr Gln Tyr Asn Leu Thr Ile Gly Ser Leu Gln Pro Glu Asp Ile 
65                  70                  75                  80  


Ala Thr Tyr Tyr Cys Gln Val Tyr Glu Phe Phe Gly Pro Gly Thr Arg 
                85                  90                  95      


Leu Asp Leu Lys Ser Thr Val Ala 
            100                 


<210> 34
<211> 119
<212> PRT
<213> Homo sapiens

<400> 34
Gln Val Gln Leu Val Gln Ser Gly Thr Ala Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Phe Ile Tyr Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu Thr Ser Gln Pro Ser Tyr Pro Ser Arg Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Arg Asp Thr Phe Asp Glu Met Leu Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Gly Leu Arg Ser Asp Asp Thr Gly Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg His Ser Asp Tyr Cys Asp Phe Asp Ile Trp Gly Ser Gly 
            100                 105                 110         


Thr Gln Ile Ile Val Ser Ser 
        115                 


<210> 35
<211> 103
<212> PRT
<213> Homo sapiens

<400> 35
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Arg Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Ile Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Ala Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala 
            100             


<210> 36
<211> 123
<212> PRT
<213> Homo sapiens

<400> 36
Gln Val Gln Leu Leu Gln Ser Gly Ala Val Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Lys Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Gln Thr Gly Gln Pro Asn Ile Pro Arg Pro Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Ile Tyr Phe Cys Ala Arg Arg Arg Ser Asp Tyr Cys Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr His Val Thr Val Ser Ser 
        115                 120             


<210> 37
<211> 107
<212> PRT
<213> Homo sapiens

<400> 37
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Gln Ala Ser Arg Asp Thr Gly Ser Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Val Gly Arg Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Ala Val Ser Asn Leu Gly Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Arg Ser Gly Thr Gln Ser Thr Leu Thr Ile Asn Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Tyr Glu Phe Phe Gly Pro 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala 
            100                 105         


<210> 38
<211> 125
<212> PRT
<213> Homo sapiens

<400> 38
Glu Val Gln Leu Val Gln Ser Gly Ser Asp Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Thr Val Ser Cys Lys Ala Asp Glu Asp Glu Asp Asp Phe Thr 
            20                  25                  30          


Ala Tyr Asn Tyr Phe Met His Trp Val Arg Gln Ala Pro Gly His Gly 
        35                  40                  45              


Leu Glu Trp Ile Gly Trp Ile Asn Pro Arg Thr Gly Gln Pro Asn His 
    50                  55                  60                  


Ala Lys Gln Phe Gln Gly Arg Val Thr Leu Thr Arg Glu Arg Ser Thr 
65                  70                  75                  80  


Ser Thr Val Phe Met Lys Leu Thr Asn Leu Arg Leu Asp Asp Thr Ala 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Pro Leu Arg Gly Gly Asp Thr Trp His Tyr 
            100                 105                 110         


His Ser Trp Gly Arg Gly Thr Ser Leu Thr Val Ser Ser 
        115                 120                 125 


<210> 39
<211> 104
<212> PRT
<213> Homo sapiens

<400> 39
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Thr Ser Ala Gly Tyr Leu Asn Trp 
            20                  25                  30          


Tyr Gln Gln Arg Arg Gly Arg Ala Pro Lys Leu Leu Met Tyr Asp Gly 
        35                  40                  45              


Ser Arg Leu Val Thr Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp 
    50                  55                  60                  


Gly Thr Gln Tyr Asn Leu Thr Ile Gly Ser Leu Gln Pro Glu Asp Val 
65                  70                  75                  80  


Ala Thr Tyr Tyr Cys Gln Val Tyr Glu Phe Phe Gly Pro Gly Thr Arg 
                85                  90                  95      


Leu Asp Leu Lys Arg Thr Val Ala 
            100                 


<210> 40
<211> 119
<212> PRT
<213> Homo sapiens

<400> 40
Gln Val Gln Leu Val Gln Ser Gly Thr Ala Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Ala Ser Gly Tyr Thr Phe Ile Asp His 
            20                  25                  30          


Phe Ile Tyr Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu Thr Ser Gln Pro Ser Tyr Pro Ser Arg Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Arg Asp Thr Phe Asp Glu Met Leu Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Gly Leu Arg Ser Asp Asp Thr Gly Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg His Ser Asp Tyr Cys Asp Phe Asp Ile Trp Gly Ser Gly 
            100                 105                 110         


Thr Gln Ile Ile Val Ser Ser 
        115                 


<210> 41
<211> 122
<212> PRT
<213> Homo sapiens

<400> 41
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Gly Gln Gly Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Lys Lys Pro Gly Arg Ala Pro Lys Leu Leu Val 
        35                  40                  45              


His Gly Ala Ser Asn Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Thr Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Val Ala Thr Tyr Phe Cys Ala Val Phe Gln Trp Phe Gly Pro 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120         


<210> 42
<211> 127
<212> PRT
<213> Homo sapiens

<400> 42
Ser Gln His Leu Val Gln Ser Gly Thr Gln Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ile Leu His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Lys Pro Val Phe Gly Ala Val Asn Tyr Ala Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Ile Gln Leu Thr Arg Asp Ile Tyr Arg Glu Ile Ala Phe 
65                  70                  75                  80  


Leu Asp Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Ser Gly Asp Asp Leu Lys Trp His Leu His Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Ile Val Ser Pro Ala Ser Thr Lys Gly 
        115                 120                 125         


<210> 43
<211> 101
<212> PRT
<213> Homo sapiens

<400> 43
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Leu Ser Cys Thr Ala Ala Ser Tyr Gly His Met Thr 
            20                  25                  30          


Trp Tyr Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Ala 
        35                  40                  45              


Thr Ser Lys Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gln 
    50                  55                  60                  


Phe Gly Lys Gln Tyr Thr Leu Thr Ile Thr Arg Met Glu Pro Glu Asp 
65                  70                  75                  80  


Phe Ala Gly Tyr Tyr Cys Gln Gln Val Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Arg Leu Glu Ile Arg 
            100     


<210> 44
<211> 125
<212> PRT
<213> Homo sapiens

<400> 44
Gln Val Gln Leu Val Gln Ser Gly Ser Gly Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Trp Thr Ser Glu Asp Ile Phe Glu Arg Thr 
            20                  25                  30          


Glu Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Val Lys Thr Val Thr Gly Ala Val Asn Phe Gly Ser Pro 
    50                  55                  60                  


Asn Phe Arg His Arg Val Ser Leu Thr Arg Asp Arg Asp Leu Phe Thr 
65                  70                  75                  80  


Ala His Met Asp Ile Arg Gly Leu Thr Gln Gly Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Gln Lys Phe Glu Arg Gly Gly Gln Gly Trp Tyr Phe 
            100                 105                 110         


Asp Leu Trp Gly Arg Gly Thr Leu Ile Val Val Ser Ser 
        115                 120                 125 


<210> 45
<211> 128
<212> PRT
<213> Homo sapiens

<400> 45
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Ala Ser Phe Ser Cys Arg Thr Ser Asp Asp Ile Tyr Asp Asn Glu 
            20                  25                  30          


Phe Phe Asp Ser Ala Phe Met His Trp Val Arg Leu Ile Pro Gly Gln 
        35                  40                  45              


Arg Pro Glu Trp Met Gly Trp Met Asn Pro Arg Ser Gly Ala Val Asn 
    50                  55                  60                  


Tyr Ala Arg Gln Leu Gln Pro Arg Val Ser Met Tyr Arg Asp Arg Asp 
65                  70                  75                  80  


Leu Ser Thr Ala Tyr Met Glu Phe Lys Ser Leu Thr Ser Ala Asp Thr 
                85                  90                  95      


Gly Thr Tyr Phe Cys Ala Arg Lys Lys Arg Gly Asp Gly Phe Asn Leu 
            100                 105                 110         


Tyr Phe Asp Leu Trp Gly Arg Gly Ser Gln Val Ile Val Ser Ser Ala 
        115                 120                 125             


<210> 46
<211> 126
<212> PRT
<213> Homo sapiens

<400> 46
Gln Val Gln Leu Val Gln Ser Gly Ser Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Trp Thr Ser Glu Asp Ile Phe Asp Thr Thr 
            20                  25                  30          


Glu Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Trp Val Lys Ala Val Ser Gly Ala Val Asn Tyr Gly Ser Leu 
    50                  55                  60                  


Asp Phe Arg His Arg Val Ser Leu Thr Arg Asp Arg Asp Leu Ser Thr 
65                  70                  75                  80  


Ala His Met Asp Ile Arg Gly Leu Thr Gln Asp Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Gln Lys Phe Ala Arg Gly Asp Gln Gly Trp Phe Phe 
            100                 105                 110         


Asp Leu Trp Gly Arg Gly Thr Leu Ile Val Val Ser Ser Ala 
        115                 120                 125     


