                         SEQUENCE LISTING

<110>  NOVADIGM THERAPEUTICS, INC.
 
<120>  METHODS AND COMPOSITIONS FOR VACCINATING AGAINST STAPHYLOCOCCUS 
       AUREUS

<130>  50665-014WO2

<140>  PCT/US12/00328
<141>  2012-07-20

<150>  61/510,896
<151>  2011-07-22

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1119
<212>  PRT
<213>  Candida albicans


<220>
<221>  PROTEIN
<222>  (1)..(1119)
<223>  Agglutinin-like sequence 3 protein (Als3p)

<400>  1

Met Leu Gln Gln Tyr Thr Leu Leu Leu Ile Tyr Leu Ser Val Ala Thr 
1               5                   10                  15      


Ala Lys Thr Ile Thr Gly Val Phe Asn Ser Phe Asn Ser Leu Thr Trp 
            20                  25                  30          


Ser Asn Ala Ala Thr Tyr Asn Tyr Lys Gly Pro Gly Thr Pro Thr Trp 
        35                  40                  45              


Asn Ala Val Leu Gly Trp Ser Leu Asp Gly Thr Ser Ala Ser Pro Gly 
    50                  55                  60                  


Asp Thr Phe Thr Leu Asn Met Pro Cys Val Phe Lys Phe Thr Thr Ser 
65                  70                  75                  80  


Gln Thr Ser Val Asp Leu Thr Ala His Gly Val Lys Tyr Ala Thr Cys 
                85                  90                  95      


Gln Phe Gln Ala Gly Glu Glu Phe Met Thr Phe Ser Thr Leu Thr Cys 
            100                 105                 110         


Thr Val Ser Asn Thr Leu Thr Pro Ser Ile Lys Ala Leu Gly Thr Val 
        115                 120                 125             


Thr Leu Pro Leu Ala Phe Asn Val Gly Gly Thr Gly Ser Ser Val Asp 
    130                 135                 140                 


Leu Glu Asp Ser Lys Cys Phe Thr Ala Gly Thr Asn Thr Val Thr Phe 
145                 150                 155                 160 


Asn Asp Gly Gly Lys Lys Ile Ser Ile Asn Val Asp Phe Glu Arg Ser 
                165                 170                 175     


Asn Val Asp Pro Lys Gly Tyr Leu Thr Asp Ser Arg Val Ile Pro Ser 
            180                 185                 190         


Leu Asn Lys Val Ser Thr Leu Phe Val Ala Pro Gln Cys Ala Asn Gly 
        195                 200                 205             


Tyr Thr Ser Gly Thr Met Gly Phe Ala Asn Thr Tyr Gly Asp Val Gln 
    210                 215                 220                 


Ile Asp Cys Ser Asn Ile His Val Gly Ile Thr Lys Gly Leu Asn Asp 
225                 230                 235                 240 


Trp Asn Tyr Pro Val Ser Ser Glu Ser Phe Ser Tyr Thr Lys Thr Cys 
                245                 250                 255     


Ser Ser Asn Gly Ile Phe Ile Thr Tyr Lys Asn Val Pro Ala Gly Tyr 
            260                 265                 270         


Arg Pro Phe Val Asp Ala Tyr Ile Ser Ala Thr Asp Val Asn Ser Tyr 
        275                 280                 285             


Thr Leu Ser Tyr Ala Asn Glu Tyr Thr Cys Ala Gly Gly Tyr Trp Gln 
    290                 295                 300                 


Arg Ala Pro Phe Thr Leu Arg Trp Thr Gly Tyr Arg Asn Ser Asp Ala 
305                 310                 315                 320 


Gly Ser Asn Gly Ile Val Ile Val Ala Thr Thr Arg Thr Val Thr Asp 
                325                 330                 335     


Ser Thr Thr Ala Val Thr Thr Leu Pro Phe Asp Pro Asn Arg Asp Lys 
            340                 345                 350         


Thr Lys Thr Ile Glu Ile Leu Lys Pro Ile Pro Thr Thr Thr Ile Thr 
        355                 360                 365             


Thr Ser Tyr Val Gly Val Thr Thr Ser Tyr Ser Thr Lys Thr Ala Pro 
    370                 375                 380                 


Ile Gly Glu Thr Ala Thr Val Ile Val Asp Ile Pro Tyr His Thr Thr 
385                 390                 395                 400 


Thr Thr Val Thr Ser Lys Trp Thr Gly Thr Ile Thr Ser Thr Thr Thr 
                405                 410                 415     


His Thr Asn Pro Thr Asp Ser Ile Asp Thr Val Ile Val Gln Val Pro 
            420                 425                 430         


Ser Pro Asn Pro Thr Val Thr Thr Thr Glu Tyr Trp Ser Gln Ser Phe 
        435                 440                 445             


Ala Thr Thr Thr Thr Ile Thr Gly Pro Pro Gly Asn Thr Asp Thr Val 
    450                 455                 460                 


Leu Ile Arg Glu Pro Pro Asn His Thr Val Thr Thr Thr Glu Tyr Trp 
465                 470                 475                 480 


Ser Glu Ser Tyr Thr Thr Thr Ser Thr Phe Thr Ala Pro Pro Gly Gly 
                485                 490                 495     


Thr Asp Ser Val Ile Ile Lys Glu Pro Pro Asn Pro Thr Val Thr Thr 
            500                 505                 510         


Thr Glu Tyr Trp Ser Glu Ser Tyr Thr Thr Thr Ser Thr Phe Thr Ala 
        515                 520                 525             


Pro Pro Gly Gly Thr Asp Ser Val Ile Ile Lys Glu Pro Pro Asn His 
    530                 535                 540                 


Thr Val Thr Thr Thr Glu Tyr Trp Ser Gln Ser Tyr Thr Thr Thr Thr 
545                 550                 555                 560 


Thr Val Thr Ala Pro Pro Gly Gly Thr Asp Thr Val Leu Val Arg Glu 
                565                 570                 575     


Pro Pro Asn His Thr Val Thr Thr Thr Glu Tyr Trp Ser Gln Ser Tyr 
            580                 585                 590         


Thr Thr Thr Thr Thr Val Ile Ala Pro Pro Gly Gly Thr Asp Ser Val 
        595                 600                 605             


Ile Ile Arg Glu Pro Pro Asn Pro Thr Val Thr Thr Thr Glu Tyr Trp 
    610                 615                 620                 


Ser Gln Ser Tyr Ala Thr Thr Thr Thr Ile Thr Ala Pro Pro Gly Glu 
625                 630                 635                 640 


Thr Asp Thr Val Leu Ile Arg Glu Pro Pro Asn His Thr Val Thr Thr 
                645                 650                 655     


Thr Glu Tyr Trp Ser Gln Ser Tyr Ala Thr Thr Thr Thr Ile Thr Ala 
            660                 665                 670         


Pro Pro Gly Glu Thr Asp Thr Val Leu Ile Arg Glu Pro Pro Asn His 
        675                 680                 685             


Thr Val Thr Thr Thr Glu Tyr Trp Ser Gln Ser Phe Ala Thr Thr Thr 
    690                 695                 700                 


Thr Val Thr Ala Pro Pro Gly Gly Thr Asp Thr Val Ile Ile Arg Glu 
705                 710                 715                 720 


Pro Pro Asn His Thr Val Thr Thr Thr Glu Tyr Trp Ser Gln Ser Tyr 
                725                 730                 735     


Ala Thr Thr Thr Thr Ile Thr Ala Pro Pro Gly Glu Thr Asp Thr Val 
            740                 745                 750         


Leu Ile Arg Glu Pro Pro Asn His Thr Val Thr Thr Thr Glu Tyr Trp 
        755                 760                 765             


Ser Gln Ser Tyr Ala Thr Thr Thr Thr Ile Ile Ala Pro Pro Gly Glu 
    770                 775                 780                 


Thr Asp Thr Val Leu Ile Arg Glu Pro Pro Asn Pro Thr Val Thr Thr 
785                 790                 795                 800 


Thr Glu Tyr Trp Ser Gln Ser Tyr Thr Thr Ala Thr Thr Val Thr Ala 
                805                 810                 815     


Pro Pro Gly Gly Thr Asp Thr Val Ile Ile Tyr Asp Thr Met Ser Ser 
            820                 825                 830         


Ser Glu Ile Ser Ser Phe Ser Arg Pro His Tyr Thr Asn His Thr Thr 
        835                 840                 845             


Leu Trp Ser Thr Thr Trp Val Ile Glu Thr Lys Thr Ile Thr Glu Thr 
    850                 855                 860                 


Ser Cys Glu Gly Asp Lys Gly Cys Ser Trp Val Ser Val Ser Thr Arg 
865                 870                 875                 880 


Ile Val Thr Ile Pro Asn Asn Ile Glu Thr Pro Met Val Thr Asn Thr 
                885                 890                 895     


Val Asp Ser Thr Thr Thr Glu Ser Thr Ser Gln Ser Pro Ser Gly Ile 
            900                 905                 910         


Phe Ser Glu Ser Gly Val Ser Val Glu Thr Glu Ser Ser Thr Val Thr 
        915                 920                 925             


Thr Ala Gln Thr Asn Pro Ser Val Pro Thr Thr Glu Ser Glu Val Val 
    930                 935                 940                 


Phe Thr Thr Lys Gly Asn Asn Glu Asn Gly Pro Tyr Glu Ser Pro Ser 
945                 950                 955                 960 


Thr Asn Val Lys Ser Ser Met Asp Glu Asn Ser Glu Phe Thr Thr Ser 
                965                 970                 975     


Thr Ala Ala Ser Thr Ser Thr Asp Ile Glu Asn Glu Thr Ile Ala Thr 
            980                 985                 990         


Thr Gly Ser Val Glu Ala Ser Ser  Pro Ile Ile Ser Ser  Ser Ala Asp 
        995                 1000                 1005             


Glu Thr  Thr Thr Val Thr Thr  Thr Ala Glu Ser Thr  Ser Val Ile 
    1010                 1015                 1020             


Glu Gln  Pro Thr Asn Asn Asn  Gly Gly Gly Lys Ala  Pro Ser Ala 
    1025                 1030                 1035             


Thr Ser  Ser Pro Ser Thr Thr  Thr Thr Ala Asn Asn  Asp Ser Val 
    1040                 1045                 1050             


Ile Thr  Gly Thr Thr Ser Thr  Asn Gln Ser Gln Ser  Gln Ser Gln 
    1055                 1060                 1065             


Tyr Asn  Ser Asp Thr Gln Gln  Thr Thr Leu Ser Gln  Gln Met Thr 
    1070                 1075                 1080             


Ser Ser  Leu Val Ser Leu His  Met Leu Thr Thr Phe  Asp Gly Ser 
    1085                 1090                 1095             


Gly Ser  Val Ile Gln His Ser  Thr Trp Leu Cys Gly  Leu Ile Thr 
    1100                 1105                 1110             


Leu Leu  Ser Leu Phe Ile 
    1115                 


<210>  2
<211>  416
<212>  PRT
<213>  Candida albicans


<220>
<221>  PROTEIN
<222>  (1)..(416)
<223>  Agglutinin-like sequence 3 protein (Als3p)

<400>  2

Lys Thr Ile Thr Gly Val Phe Asn Ser Phe Asn Ser Leu Thr Trp Ser 
1               5                   10                  15      


Asn Ala Ala Thr Tyr Asn Tyr Lys Gly Pro Gly Thr Pro Thr Trp Asn 
            20                  25                  30          


Ala Val Leu Gly Trp Ser Leu Asp Gly Thr Ser Ala Ser Pro Gly Asp 
        35                  40                  45              


Thr Phe Thr Leu Asn Met Pro Cys Val Phe Lys Phe Thr Thr Ser Gln 
    50                  55                  60                  


Thr Ser Val Asp Leu Thr Ala His Gly Val Lys Tyr Ala Thr Cys Gln 
65                  70                  75                  80  


Phe Gln Ala Gly Glu Glu Phe Met Thr Phe Ser Thr Leu Thr Cys Thr 
                85                  90                  95      


Val Ser Asn Thr Leu Thr Pro Ser Ile Lys Ala Leu Gly Thr Val Thr 
            100                 105                 110         


Leu Pro Leu Ala Phe Asn Val Gly Gly Thr Gly Ser Ser Val Asp Leu 
        115                 120                 125             


Glu Asp Ser Lys Cys Phe Thr Ala Gly Thr Asn Thr Val Thr Phe Asn 
    130                 135                 140                 


Asp Gly Gly Lys Lys Ile Ser Ile Asn Val Asp Phe Glu Arg Ser Asn 
145                 150                 155                 160 


Val Asp Pro Lys Gly Tyr Leu Thr Asp Ser Arg Val Ile Pro Ser Leu 
                165                 170                 175     


Asn Lys Val Ser Thr Leu Phe Val Ala Pro Gln Cys Ala Asn Gly Tyr 
            180                 185                 190         


Thr Ser Gly Thr Met Gly Phe Ala Asn Thr Tyr Gly Asp Val Gln Ile 
        195                 200                 205             


Asp Cys Ser Asn Ile His Val Gly Ile Thr Lys Gly Leu Asn Asp Trp 
    210                 215                 220                 


Asn Tyr Pro Val Ser Ser Glu Ser Phe Ser Tyr Thr Lys Thr Cys Ser 
225                 230                 235                 240 


Ser Asn Gly Ile Phe Ile Thr Tyr Lys Asn Val Pro Ala Gly Tyr Arg 
                245                 250                 255     


Pro Phe Val Asp Ala Tyr Ile Ser Ala Thr Asp Val Asn Ser Tyr Thr 
            260                 265                 270         


Leu Ser Tyr Ala Asn Glu Tyr Thr Cys Ala Gly Gly Tyr Trp Gln Arg 
        275                 280                 285             


Ala Pro Phe Thr Leu Arg Trp Thr Gly Tyr Arg Asn Ser Asp Ala Gly 
    290                 295                 300                 


Ser Asn Gly Ile Val Ile Val Ala Thr Thr Arg Thr Val Thr Asp Ser 
305                 310                 315                 320 


Thr Thr Ala Val Thr Thr Leu Pro Phe Asp Pro Asn Arg Asp Lys Thr 
                325                 330                 335     


Lys Thr Ile Glu Ile Leu Lys Pro Ile Pro Thr Thr Thr Ile Thr Thr 
            340                 345                 350         


Ser Tyr Val Gly Val Thr Thr Ser Tyr Leu Thr Lys Thr Ala Pro Ile 
        355                 360                 365             


Gly Glu Thr Ala Thr Val Ile Val Asp Ile Pro Tyr His Thr Thr Thr 
    370                 375                 380                 


Thr Val Thr Ser Lys Trp Thr Gly Thr Ile Thr Ser Thr Thr Thr His 
385                 390                 395                 400 


Thr Asn Pro Thr Asp Ser Ile Asp Thr Val Ile Val Gln Val Pro Leu 
                405                 410                 415     


<210>  3
<211>  1251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
aagacaatca ctggtgtttt caacagtttt aattcattga cttggtctaa tgctgctacg       60

tataattata agggaccagg aaccccaact tggaatgctg ttttgggttg gtctttagat      120

ggtactagtg caagtccggg agatacattc acattgaata tgccatgtgt gtttaaattt      180

actacttctc aaacatctgt tgatttgact gctcatggtg ttaaatatgc tacatgtcaa      240

tttcaggcag gtgaagaatt tatgaccttt tctacattaa catgtactgt gagcaatact      300

ttgactccat ctattaaggc tttgggtact gtcactttac cacttgcatt caatgtaggt      360

ggaactggtt cttctgttga tttggaagat tctaaatgtt ttactgctgg tactaacaca      420

gttacattta atgatggtgg caagaaaatc tcaattaatg ttgattttga aaggtcaaat      480

gtcgatccaa aagggtactt aactgattcc agagttatac caagtctcaa caaagtgtca      540

actctttttg ttgcaccaca atgtgcaaat ggttacacat ctggtacaat gggattcgct      600

aacacttatg gtgatgttca aattgactgt tcaaatattc atgttggtat tacaaaagga      660

ttgaatgatt ggaattatcc ggtttcatct gaatcattta gttacaccaa aacttgttca      720

tctaatggta tctttatcac atataaaaac gttcctgccg gttatcgtcc atttgttgac      780

gcttatattt ctgctacaga tgttaattcg tacaccttgt cgtatgctaa tgaatatact      840

tgtgctggtg gttattggca acgtgcacct ttcacattaa gatggactgg atacagaaat      900

agtgatgctg gatctaacgg tattgttatt gtggctacta ccagaacagt tacagacagt      960

actaccgccg tgaccacctt accattcgat cctaaccgcg acaaaactaa gacaattgaa     1020

attttgaaac ctattccaac aactacaatc acaacatcat atgttggtgt gactacttcc     1080

tacctgacca aaactgcacc aattggggaa actgctactg ttattgttga tattccatat     1140

cacactacca ctactgttac cagtaaatgg acaggaacaa ttacttccac cacaacacat     1200

actaatccaa ctgactcaat agacactgtc attgtacaag ttccactgtg a              1251


