                         SEQUENCE LISTING

<110>  CARMEL-HAIFA UNIVERSITY ECONOMIC CORP
       ARIEL , Amiram
       LUTATI , Aviv
 
<120>  LACTOFERRIN FRAGMENTS AND USE THEREOF

<130>  CRML/002 PCT

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  172
<212>  PRT
<213>  Bos taurus

<400>  1

Phe Phe Ser Ala Ser Cys Val Pro Cys Ile Asp Arg Gln Ala Tyr Pro 
1               5                   10                  15      


Asn Leu Cys Gln Leu Cys Lys Gly Glu Gly Glu Asn Gln Cys Ala Cys 
            20                  25                  30          


Ser Ser Arg Glu Pro Tyr Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu 
        35                  40                  45              


Gln Asp Gly Ala Gly Asp Val Ala Phe Val Lys Glu Thr Thr Val Phe 
    50                  55                  60                  


Glu Asn Leu Pro Glu Lys Ala Asp Arg Asp Gln Tyr Glu Leu Leu Cys 
65                  70                  75                  80  


Leu Asn Asn Ser Arg Ala Pro Val Asp Ala Phe Lys Glu Cys His Leu 
                85                  90                  95      


Ala Gln Val Pro Ser His Ala Val Val Ala Arg Ser Val Asp Gly Lys 
            100                 105                 110         


Glu Asp Leu Ile Trp Lys Leu Leu Ser Lys Ala Gln Glu Lys Phe Gly 
        115                 120                 125             


Lys Asn Lys Ser Arg Ser Phe Gln Leu Phe Gly Ser Pro Pro Gly Gln 
    130                 135                 140                 


Arg Asp Leu Leu Phe Lys Asp Ser Ala Leu Gly Phe Leu Arg Ile Pro 
145                 150                 155                 160 


Ser Lys Val Asp Ser Ala Leu Tyr Leu Gly Ser Arg 
                165                 170         


<210>  2
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Phe Ser Ala Ser Cys Val Pro Gly Ala Asp Lys Gly Gln Phe Pro 
1               5                   10                  15      


Asn Leu Cys Arg Leu Cys Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe 
            20                  25                  30          


Ser Ser Gln Glu Pro Tyr Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu 
        35                  40                  45              


Arg Asp Gly Ala Gly Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe 
    50                  55                  60                  


Glu Asp Leu Ser Asp Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys 
65                  70                  75                  80  


Pro Asp Asn Thr Arg Lys Pro Val Asp Lys Phe Lys Asp Cys His Leu 
                85                  90                  95      


Ala Arg Val Pro Ser His Ala Val Val Ala Arg Ser Val Asn Gly Lys 
            100                 105                 110         


Glu Asp Ala Ile Trp Asn Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly 
        115                 120                 125             


Lys Asp Lys Ser Pro Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln 
    130                 135                 140                 


Lys Asp Leu Leu Phe Lys Asp Ser Ala Ile Gly Phe Ser Arg Val Pro 
145                 150                 155                 160 


Pro Arg Ile Asp Ser Gly Leu Tyr Leu Gly Ser Gly 
                165                 170         


<210>  3
<211>  163
<212>  PRT
<213>  Bos taurus

<400>  3

Ala Pro Arg Lys Asn Val Arg Trp Cys Thr Ile Ser Gln Pro Glu Trp 
1               5                   10                  15      


Phe Lys Cys Arg Arg Trp Gln Trp Arg Met Lys Lys Leu Gly Ala Pro 
            20                  25                  30          


Ser Ile Thr Cys Val Arg Arg Ala Phe Ala Leu Glu Cys Ile Arg Ala 
        35                  40                  45              


Ile Ala Glu Lys Lys Ala Asp Ala Val Thr Leu Asp Gly Gly Met Val 
    50                  55                  60                  


Phe Glu Ala Gly Arg Asp Pro Tyr Lys Leu Arg Pro Val Ala Ala Glu 
65                  70                  75                  80  


Ile Tyr Gly Thr Lys Glu Ser Pro Gln Thr His Tyr Tyr Ala Val Ala 
                85                  90                  95      


Val Val Lys Lys Gly Ser Asn Phe Gln Leu Asp Gln Leu Gln Gly Arg 
            100                 105                 110         


Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp Val Ile Pro 
        115                 120                 125             


Met Gly Ile Leu Arg Pro Tyr Leu Ser Trp Thr Glu Ser Leu Glu Pro 
    130                 135                 140                 


Leu Gln Gly Ala Val Ala Lys Phe Phe Ser Ala Ser Cys Val Pro Cys 
145                 150                 155                 160 


Ile Asp Arg 
            


<210>  4
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Gly Arg Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln Pro 
1               5                   10                  15      


Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg 
            20                  25                  30          


Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys Ile 
        35                  40                  45              


Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly Gly 
    50                  55                  60                  


Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val Ala 
65                  70                  75                  80  


Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr Ala 
                85                  90                  95      


Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu Gln 
            100                 105                 110         


Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp Asn 
        115                 120                 125             


Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro Pro 
    130                 135                 140                 


Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys Val 
145                 150                 155                 160 


Pro Gly Ala Asp Lys 
                165 


<210>  5
<211>  708
<212>  PRT
<213>  Bos taurus

<400>  5

Met Lys Leu Phe Val Pro Ala Leu Leu Ser Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Ala Pro Arg Lys Asn Val Arg Trp Cys Thr Ile Ser Gln 
            20                  25                  30          


Pro Glu Trp Phe Lys Cys Arg Arg Trp Gln Trp Arg Met Lys Lys Leu 
        35                  40                  45              


Gly Ala Pro Ser Ile Thr Cys Val Arg Arg Ala Phe Ala Leu Glu Cys 
    50                  55                  60                  


Ile Arg Ala Ile Ala Glu Lys Lys Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Met Val Phe Glu Ala Gly Arg Asp Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Ile Tyr Gly Thr Lys Glu Ser Pro Gln Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Ser Asn Phe Gln Leu Asp Gln Leu 
        115                 120                 125             


Gln Gly Arg Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp 
    130                 135                 140                 


Val Ile Pro Met Gly Ile Leu Arg Pro Tyr Leu Ser Trp Thr Glu Ser 
145                 150                 155                 160 


Leu Glu Pro Leu Gln Gly Ala Val Ala Lys Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Cys Ile Asp Arg Gln Ala Tyr Pro Asn Leu Cys Gln Leu Cys 
            180                 185                 190         


Lys Gly Glu Gly Glu Asn Gln Cys Ala Cys Ser Ser Arg Glu Pro Tyr 
        195                 200                 205             


Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Gln Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Val Lys Glu Thr Thr Val Phe Glu Asn Leu Pro Glu Lys 
225                 230                 235                 240 


Ala Asp Arg Asp Gln Tyr Glu Leu Leu Cys Leu Asn Asn Ser Arg Ala 
                245                 250                 255     


Pro Val Asp Ala Phe Lys Glu Cys His Leu Ala Gln Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Ser Val Asp Gly Lys Glu Asp Leu Ile Trp Lys 
        275                 280                 285             


Leu Leu Ser Lys Ala Gln Glu Lys Phe Gly Lys Asn Lys Ser Arg Ser 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Pro Gly Gln Arg Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Leu Gly Phe Leu Arg Ile Pro Ser Lys Val Asp Ser Ala 
                325                 330                 335     


Leu Tyr Leu Gly Ser Arg Tyr Leu Thr Thr Leu Lys Asn Leu Arg Glu 
            340                 345                 350         


Thr Ala Glu Glu Val Lys Ala Arg Tyr Thr Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Pro Glu Glu Gln Lys Lys Cys Gln Gln Trp Ser Gln Gln Ser 
    370                 375                 380                 


Gly Gln Asn Val Thr Cys Ala Thr Ala Ser Thr Thr Asp Asp Cys Ile 
385                 390                 395                 400 


Val Leu Val Leu Lys Gly Glu Ala Asp Ala Leu Asn Leu Asp Gly Gly 
                405                 410                 415     


Tyr Ile Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Arg Lys Thr Ser Lys Tyr Ser Ser Leu Asp Cys Val Leu Arg Pro 
        435                 440                 445             


Thr Glu Gly Tyr Leu Ala Val Ala Val Val Lys Lys Ala Asn Glu Gly 
    450                 455                 460                 


Leu Thr Trp Asn Ser Leu Lys Asp Lys Lys Ser Cys His Thr Ala Val 
465                 470                 475                 480 


Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Ile Val Asn Gln 
                485                 490                 495     


Thr Gly Ser Cys Ala Phe Asp Glu Phe Phe Ser Gln Ser Cys Ala Pro 
            500                 505                 510         


Gly Arg Asp Pro Lys Ser Arg Leu Cys Ala Leu Cys Ala Gly Asp Asp 
        515                 520                 525             


Gln Gly Leu Asp Lys Cys Val Pro Asn Ser Lys Glu Lys Tyr Tyr Gly 
    530                 535                 540                 


Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asp Val Gly Asp Val Ala 
545                 550                 555                 560 


Phe Val Lys Asn Asp Thr Val Trp Glu Asn Thr Asn Gly Glu Ser Thr 
                565                 570                 575     


Ala Asp Trp Ala Lys Asn Leu Asn Arg Glu Asp Phe Arg Leu Leu Cys 
            580                 585                 590         


Leu Asp Gly Thr Arg Lys Pro Val Thr Glu Ala Gln Ser Cys His Leu 
        595                 600                 605             


Ala Val Ala Pro Asn His Ala Val Val Ser Arg Ser Asp Arg Ala Ala 
    610                 615                 620                 


His Val Lys Gln Val Leu Leu His Gln Gln Ala Leu Phe Gly Lys Asn 
625                 630                 635                 640 


Gly Lys Asn Cys Pro Asp Lys Phe Cys Leu Phe Lys Ser Glu Thr Lys 
                645                 650                 655     


Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Lys Leu Gly Gly 
            660                 665                 670         


Arg Pro Thr Tyr Glu Glu Tyr Leu Gly Thr Glu Tyr Val Thr Ala Ile 
        675                 680                 685             


Ala Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Ala 
    690                 695                 700                 


Phe Leu Thr Arg 
705             


<210>  6
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser 
            20                  25                  30          


Gln Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys 
        35                  40                  45              


Val Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln 
    50                  55                  60                  


Cys Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp 
65                  70                  75                  80  


Gly Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro 
                85                  90                  95      


Val Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr 
            100                 105                 110         


Tyr Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu 
        115                 120                 125             


Leu Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly 
    130                 135                 140                 


Trp Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser 
                165                 170                 175     


Cys Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu 
            180                 185                 190         


Cys Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro 
        195                 200                 205             


Tyr Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly 
    210                 215                 220                 


Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp 
225                 230                 235                 240 


Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg 
                245                 250                 255     


Lys Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser 
            260                 265                 270         


His Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp 
        275                 280                 285             


Asn Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro 
    290                 295                 300                 


Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe 
305                 310                 315                 320 


Lys Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser 
                325                 330                 335     


Gly Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg 
            340                 345                 350         


Lys Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys 
        355                 360                 365             


Ala Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu 
    370                 375                 380                 


Ser Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys 
385                 390                 395                 400 


Ile Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Glu 
                405                 410                 415     


Gly Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala 
            420                 425                 430         


Glu Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val 
        435                 440                 445             


Asp Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser 
    450                 455                 460                 


Asp Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His 
465                 470                 475                 480 


Thr Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu 
                485                 490                 495     


Phe Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser 
            500                 505                 510         


Cys Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile 
        515                 520                 525             


Gly Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg 
    530                 535                 540                 


Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly 
545                 550                 555                 560 


Asp Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly 
                565                 570                 575     


Asn Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala 
            580                 585                 590         


Leu Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser 
        595                 600                 605             


Cys His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp 
    610                 615                 620                 


Lys Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe 
625                 630                 635                 640 


Gly Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser 
                645                 650                 655     


Glu Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg 
            660                 665                 670         


Leu His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val 
        675                 680                 685             


Ala Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu 
    690                 695                 700                 


Ala Cys Glu Phe Leu Arg Lys 
705                 710     


<210>  7
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  7

Glu Pro Tyr Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Gln Asp Gly 
1               5                   10                  15      


Ala Gly Asp Val Ala Phe Val Lys Glu Thr Thr Val Phe Glu Asn Leu 
            20                  25                  30          


Pro Glu Lys 
        35  


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  8

Ser Val Asp Gly Lys Glu Asp Leu Ile Trp Lys 
1               5                   10      


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  9

Val Asp Ser Ala Leu Tyr Leu Gly Ser Arg 
1               5                   10  


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  10

Phe Phe Ser Ala Ser Cys Val Pro Cys Ile Asp Arg 
1               5                   10          


<210>  11
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  11

Trp Phe Lys Cys Arg Arg Trp Gln Trp Arg Met Lys Lys Leu Gly Ala 
1               5                   10                  15      


Pro Ser Ile Thr Cys Val Arg Arg Ala Phe 
            20                  25      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  12

Trp Cys Thr Ile Ser Gln Pro Glu Trp Phe Lys 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  13

Lys Leu Gly Ala Pro Ser Ile Thr Cys Val Arg 
1               5                   10      


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  14

Arg Ala Phe Ala Leu Glu Cys Ile Arg 
1               5                   


<210>  15
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  15

Lys Ala Asp Ala Val Thr Leu Asp Gly Gly Met Val Phe Glu Ala Gly 
1               5                   10                  15      


Arg Asp Pro Tyr Lys 
            20      


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  16

Leu Arg Pro Val Ala Ala Glu Ile Tyr Gly Thr Lys 
1               5                   10          


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  17

Glu Ser Pro Gln Thr His Tyr Tyr Ala Val Ala Val Val Lys 
1               5                   10                  


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  18

Lys Gly Ser Asn Phe Gln Leu Asp Gln Leu Gln Gly Arg 
1               5                   10              


<210>  19
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  19

Leu Gln Gly Ala Val Ala Lys Phe Phe Ser Ala Ser Cys Val Pro Cys 
1               5                   10                  15      


Ile Asp Arg Gln Ala Tyr Pro Asn Leu Cys Gln Leu Cys Lys Gly Glu 
            20                  25                  30          


Gly Glu Asn Gln Cys Ala Cys Ser Ser Arg Glu Pro Tyr Phe Gly Tyr 
        35                  40                  45              


Ser Gly Ala Phe Lys Cys Leu Gln Asp Gly Ala Gly Asp Val Ala Phe 
    50                  55                  60                  


Val 
65  


