                         SEQUENCE LISTING

<110>  CSL
 
<120>  Antibodies

<130>  A172

<150>  EP11175105
<151>  2011-07-22

<150>  US 61/510801
<151>  2011-07-22

<150>  EP12153310
<151>  2012-01-31

<160>  77    

<170>  PatentIn version 3.3

<210>  1
<211>  615
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys 
            20                  25                  30          


Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys 
    50                  55                  60                  


Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn 
            100                 105                 110         


Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe 
    130                 135                 140                 


His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg 
145                 150                 155                 160 


Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln 
                165                 170                 175     


Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val 
            180                 185                 190         


Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Ala Phe 
        195                 200                 205             


Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro 
225                 230                 235                 240 


Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg 
                245                 250                 255     


Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu 
        275                 280                 285             


Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro 
    290                 295                 300                 


Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro 
305                 310                 315                 320 


Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln 
                325                 330                 335     


Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr 
            340                 345                 350         


Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser 
        355                 360                 365             


Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His 
    370                 375                 380                 


Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser 
385                 390                 395                 400 


Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp 
                405                 410                 415     


Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg 
            420                 425                 430         


Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg 
        435                 440                 445             


Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu 
    450                 455                 460                 


Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro 
465                 470                 475                 480 


Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu 
                485                 490                 495     


Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala 
            500                 505                 510         


Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser 
        515                 520                 525             


Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro 
    530                 535                 540                 


Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln 
545                 550                 555                 560 


Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg 
                565                 570                 575     


Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp 
            580                 585                 590         


Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp 
        595                 600                 605             


Ile Arg Glu His Thr Val Ser 
    610                 615 


<210>  2
<211>  597
<212>  PRT
<213>  Mus musculus

<400>  2

Met Thr Ala Leu Leu Phe Leu Gly Ser Leu Leu Met Ser Leu Asp Leu 
1               5                   10                  15      


Thr Leu Ser Ala Pro Pro Trp Lys Asp Ser Lys Lys Phe Lys Asp Ala 
            20                  25                  30          


Pro Asp Gly Pro Thr Val Val Leu Thr Val Asp Gly Arg Leu Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu His His Lys Cys Ile His Lys 
    50                  55                  60                  


Arg Arg Pro Gly Ser Arg Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Glu Asp Gln Gln Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Asn Pro Cys His Lys Gly Gly Thr Cys Ile Asn 
            100                 105                 110         


Thr Pro Asn Gly Pro His Cys Leu Cys Pro Glu His Leu Thr Gly Lys 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Lys Phe Phe 
    130                 135                 140                 


His Glu Asn Glu Leu Trp Phe Arg Thr Gly Pro Gly Gly Val Ala Arg 
145                 150                 155                 160 


Cys Glu Cys Lys Gly Ser Glu Ala His Cys Lys Pro Val Ala Ser Gln 
                165                 170                 175     


Ala Cys Ser Ile Asn Pro Cys Leu Asn Gly Gly Ser Cys Leu Leu Val 
            180                 185                 190         


Glu Asp His Pro Leu Cys Arg Cys Pro Thr Gly Tyr Thr Gly Tyr Phe 
        195                 200                 205             


Cys Asp Leu Asp Leu Trp Ala Thr Cys Tyr Glu Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Gln Ala Gly Thr Thr Gln Ser Gly Ala Pro Cys Gln Arg 
225                 230                 235                 240 


Trp Thr Val Glu Ala Thr Tyr Arg Asn Met Thr Glu Lys Gln Ala Leu 
                245                 250                 255     


Ser Trp Gly Leu Gly His His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Thr Arg Pro Trp Cys Phe Val Trp Ser Gly Asp Arg Leu Ser Trp Asp 
        275                 280                 285             


Tyr Cys Gly Leu Glu Gln Cys Gln Thr Pro Thr Phe Ala Pro Leu Val 
    290                 295                 300                 


Val Pro Glu Ser Gln Glu Glu Ser Pro Ser Gln Ala Pro Ser Leu Ser 
305                 310                 315                 320 


His Ala Pro Asn Asp Ser Thr Asp His Gln Thr Ser Leu Ser Lys Thr 
                325                 330                 335     


Asn Thr Met Gly Cys Gly Gln Arg Phe Arg Lys Gly Leu Ser Ser Phe 
            340                 345                 350         


Met Arg Val Val Gly Gly Leu Val Ala Leu Pro Gly Ser His Pro Tyr 
        355                 360                 365             


Ile Ala Ala Leu Tyr Trp Gly Asn Asn Phe Cys Ala Gly Ser Leu Ile 
    370                 375                 380                 


Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asn Arg Pro 
385                 390                 395                 400 


Ala Pro Glu Glu Leu Thr Val Val Leu Gly Gln Asp Arg His Asn Gln 
                405                 410                 415     


Ser Cys Glu Trp Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg Leu His 
            420                 425                 430         


Glu Gly Phe Ser Ser Ile Thr Tyr Gln His Asp Leu Ala Leu Leu Arg 
        435                 440                 445             


Leu Gln Glu Ser Lys Thr Asn Ser Cys Ala Ile Leu Ser Pro His Val 
    450                 455                 460                 


Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Pro Pro Ser Glu Thr Val 
465                 470                 475                 480 


Leu Cys Glu Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala Glu Glu 
                485                 490                 495     


Tyr Ser Thr Phe Leu Gln Glu Ala Gln Val Pro Phe Ile Ala Leu Asp 
            500                 505                 510         


Arg Cys Ser Asn Ser Asn Val His Gly Asp Ala Ile Leu Pro Gly Met 
        515                 520                 525             


Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln Gly Asp 
    530                 535                 540                 


Ser Gly Gly Pro Leu Val Cys Glu Glu Gly Thr Ala Glu His Gln Leu 
545                 550                 555                 560 


Thr Leu Arg Gly Val Ile Ser Trp Gly Ser Gly Cys Gly Asp Arg Asn 
                565                 570                 575     


Lys Pro Gly Val Tyr Thr Asp Val Ala Asn Tyr Leu Ala Trp Ile Gln 
            580                 585                 590         


Lys His Ile Ala Ser 
        595         


<210>  3
<211>  595
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Thr Ala Leu Leu Phe Leu Gly Ser Leu Leu Met Ser Leu Asp Leu 
1               5                   10                  15      


Thr Leu Ser Ala Pro Pro Trp Lys Ser Lys Glu Phe Lys Asp Gly Ala 
            20                  25                  30          


Gly Asp Pro Ser Val Val Leu Thr Val Asp Gly Lys Leu Cys His Phe 
        35                  40                  45              


Pro Phe Gln Tyr His Arg Arg Leu Tyr His Lys Cys Ile His Lys Gly 
    50                  55                  60                  


Gln Pro Gly Ser Arg Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp Glu 
65                  70                  75                  80  


Asp Gln Gln Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp His 
                85                  90                  95      


Cys Ser Lys His Ser Pro Cys His Lys Gly Gly Thr Cys Val Asn Thr 
            100                 105                 110         


Pro Asn Gly Pro His Cys Leu Cys Pro Glu His Leu Thr Gly Lys His 
        115                 120                 125             


Cys Gln Arg Glu Lys Cys Phe Glu Ser Gln Leu Leu Lys Phe Phe His 
    130                 135                 140                 


Glu Asn Glu Ile Trp Phe Arg Thr Gly Pro Gly Gly Val Ala Arg Cys 
145                 150                 155                 160 


Gln Cys Lys Gly Pro Gln Ala Val Cys Lys Leu Leu Thr Ser Gln Val 
                165                 170                 175     


Cys Arg Val Asn Pro Cys Leu Asn Gly Gly Thr Cys Leu Leu Val Glu 
            180                 185                 190         


Asp His Arg Leu Cys His Cys Pro Ala Gly Tyr Ala Gly Pro Phe Cys 
        195                 200                 205             


Asp Leu Asp Leu Lys Ala Thr Cys Tyr Glu Asp Arg Gly Leu Ser Tyr 
    210                 215                 220                 


Arg Gly Gln Ala Lys Thr Thr Leu Ser Gly Ala Pro Cys Gln Arg Trp 
225                 230                 235                 240 


Ala Ser Glu Ala Thr Tyr Arg Asn Met Thr Glu Thr Gln Ala Leu Ser 
                245                 250                 255     


Trp Gly Leu Gly His His Ala Phe Cys Arg Asn Pro Asp Asn Asp Thr 
            260                 265                 270         


Arg Pro Trp Cys Tyr Val Trp Ser Gly Asp Arg Leu Ser Trp Asp Tyr 
        275                 280                 285             


Cys Asp Leu Glu Gln Cys Gln Met Pro Thr Leu Thr Ser Pro Val Ser 
    290                 295                 300                 


Pro Glu Ser His Asp Met Leu Lys Pro Arg Pro Pro Ile Leu Gln Ser 
305                 310                 315                 320 


Ser Pro Arg Asp Ser Thr Arg Asn Gln Asn Val Val Ser Arg Thr Ser 
                325                 330                 335     


Thr Val Val Cys Gly Gln Arg Phe Arg Lys Arg Leu Ser Ser Leu Arg 
            340                 345                 350         


Arg Val Val Gly Gly Leu Val Ala Leu Pro Gly Ser His Pro Tyr Ile 
        355                 360                 365             


Ala Ala Leu Tyr Trp Gly Asp Ser Phe Cys Ala Gly Ser Leu Ile Asp 
    370                 375                 380                 


Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Lys Arg Pro Ala 
385                 390                 395                 400 


Pro Glu Glu Leu Thr Val Val Leu Gly Gln Asp Arg His Asn Gln Ser 
                405                 410                 415     


Cys Glu Arg Cys Gln Thr Leu Ala Val His Ser Tyr Arg Leu His Glu 
            420                 425                 430         


Gly Phe Ser Ser Lys Thr Tyr Gln His Asp Leu Ala Leu Leu Arg Leu 
        435                 440                 445             


Arg Gly Arg Lys Asn Ser Cys Ala Ile Leu Ser Pro His Val Gln Pro 
    450                 455                 460                 


Val Cys Leu Pro Ser Ser Ala Ala Pro Pro Ser Glu Thr Val Leu Cys 
465                 470                 475                 480 


Glu Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala Glu Glu Tyr Ala 
                485                 490                 495     


Thr Phe Leu Gln Glu Ala Gln Val Pro Phe Ile Ser Leu Asp Arg Cys 
            500                 505                 510         


Ser Ser Ser Asn Val His Gly Asp Ala Ile Leu Pro Gly Met Leu Cys 
        515                 520                 525             


Ala Gly Phe Leu Glu Gly Gly Ala Asp Ala Cys Gln Gly Asp Ser Gly 
    530                 535                 540                 


Gly Pro Leu Val Cys Asp Glu Gly Val Thr Glu Arg Gln Leu Thr Leu 
545                 550                 555                 560 


Arg Gly Val Ile Ser Trp Gly Ser Gly Cys Gly Asp Arg Asn Lys Pro 
                565                 570                 575     


Gly Val Tyr Thr Asp Val Ala Asn Tyr Leu Asp Trp Ile Gln Glu His 
            580                 585                 590         


Thr Ala Phe 
        595 


<210>  4
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  5
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu 
                85                  90                  95      


Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  6
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Tyr Ile Met Gln 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain CDR2 showing variations

<220>  
<221>  V-segment
<222>  (3)..(3)
<223>  Xaa is selected from Arg, Asn, and Asp

<220>  
<221>  V-segment
<222>  (4)..(4)
<223>  Xaa is selcted from Pro, Val, Ile and Met

<220>  
<221>  V-segment
<222>  (5)..(5)
<223>  Xaa is selected from Ser, Pro and Ala

<220>  
<221>  V-segment
<222>  (6)..(6)
<223>  Xaa is selected from Gly, Leu, Val and Thr

<220>  
<221>  V-segment
<222>  (7)..(7)
<223>  Xaa is selected from Gly, Tyr, Gln, Lys, Arg, Asn and Met

<220>  
<221>  V-segment
<222>  (8)..(8)
<223>  Xaa is selected from Thr, Gly and Ser



<400>  8

Gly Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain CDR3 showing variations

<220>  
<221>  V-segment
<222>  (9)..(9)
<223>  Xaa is selected from Ala, Met and Val

<220>  
<221>  V-segment
<222>  (10)..(10)
<223>  Xaa is selcted from Ser and Lys

<220>  
<221>  V-segment
<222>  (11)..(11)
<223>  Xaa is selected from Pro, Lys, Thr and His

<220>  
<221>  V-segment
<222>  (12)..(12)
<223>  Xaa is selected from His, Asn, Gly and Gln

<400>  10

Ala Leu Pro Arg Ser Gly Tyr Leu Xaa Xaa Xaa Xaa Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  11
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Tyr Val Tyr 
1               5                   10              


<210>  12
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Ala Trp Asp Ala Ser Leu Arg Gly Val 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain CDR3 showing variations

<220>  
<221>  V-segment
<222>  (2)..(2)
<223>  Xaa is selected from Ala and Ser

<220>  
<221>  V-segment
<222>  (4)..(6)
<223>  Xaa can be any amino acid

<220>  
<221>  V-segment
<222>  (7)..(7)
<223>  Xaa is selected from Leu and Val

<220>  
<221>  V-segment
<222>  (9)..(10)
<223>  Xaa can be any amino acid

<400>  14

Ala Xaa Trp Xaa Xaa Xaa Xaa Arg Xaa Xaa 
1               5                   10  


<210>  15
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  stop template to generate diverse antibodies

<220>  
<221>  misc_feature
<222>  (30)..(35)
<223>  Xaa can be any naturally occurring amino acid (except Cys)

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 


<210>  16
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic trimer mix


<220>
<221>  misc_feature
<222>  (20)..(37)
<223>  n is a, c, g, or t

<400>  16
agcaagcggt tttacctttn nnnnnnnnnn nnnnnnntgg gttcgccagg cac            53


<210>  17
<211>  133
<212>  PRT
<213>  Artificial

<220>
<223>  stop template to generate diverse antibodies


<220>
<221>  misc_feature
<222>  (52)..(57)
<223>  Xaa can be any naturally occurring amino acid (except Cys)

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  18
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic trimer mix


<220>
<221>  misc_feature
<222>  (20)..(37)
<223>  n is a, c, g, or t

<400>  18
ggaatgggtt agcggtattn nnnnnnnnnn nnnnnnnacc gtttatgcag atagcg         56


<210>  19
<211>  133
<212>  PRT
<213>  Artificial

<220>
<223>  stop template to generate diverse antibodies


<220>
<221>  misc_feature
<222>  (100)..(105)
<223>  Xaa can be any naturally occurring amino acid (except Cys)

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Xaa Xaa Xaa Xaa Xaa Xaa Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  20
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic trimer mix


<220>
<221>  misc_feature
<222>  (20)..(37)
<223>  n is a, c, g, or t

<400>  20
ttattattgc gcacgtgcan nnnnnnnnnn nnnnnnnctg atttctccgc attatta        57


<210>  21
<211>  133
<212>  PRT
<213>  Artificial

<220>
<223>  stop template to generate diverse antibodies


<220>
<221>  misc_feature
<222>  (105)..(110)
<223>  Xaa can be any naturally occurring amino acid (except Cys)

<400>  21

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Xaa Xaa Xaa Xaa Xaa Xaa Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys 
    130             


<210>  22
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic trimer mix


<220>
<221>  misc_feature
<222>  (18)..(35)
<223>  n is a, c, g, or t

<400>  22
cactgcctcg tagcggtnnn nnnnnnnnnn nnnnntatta ttattatgcc ctggat         56


<210>  23
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  stop template to generate diverse antibodies


<220>
<221>  misc_feature
<222>  (27)..(32)
<223>  Xaa can be any naturally occurring amino acid (except Cys)

<400>  23

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu 
                85                  90                  95      


Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120 


<210>  24
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic trimer mix


<220>
<221>  misc_feature
<222>  (18)..(35)
<223>  n is a, c, g, or t

<400>  24
gctgtagcgg tagcagcnnn nnnnnnnnnn nnnnntatgt gtattggtat cagca          55


<210>  25
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  stop template to generate diverse antibodies


<220>
<221>  misc_feature
<222>  (90)..(95)
<223>  Xaa can be any naturally occurring amino acid (except Cys)

<400>  25

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Leu 
                85                  90                  95      


Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120 


<210>  26
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic trimer mix


<220>
<221>  misc_feature
<222>  (22)..(39)
<223>  n is a, c, g, or t

<400>  26
gatgaagccg attattattg tnnnnnnnnn nnnnnnnnnc tgcgtggtgt ttttggt        57


<210>  27
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  stop template to generate diverse antibodies


<220>
<221>  misc_feature
<222>  (94)..(99)
<223>  Xaa can be any naturally occurring amino acid (except Cys)

<400>  27

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120 


<210>  28
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic trimer mix


<220>
<221>  misc_feature
<222>  (20)..(37)
<223>  n is a, c, g, or t

<400>  28
ttattgtgca gcatgggatn nnnnnnnnnn nnnnnnnttt ggtggtggca ccaaa          55


<210>  29
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  29

Gly Ile Asn Val Pro Leu Tyr Gly Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  30

Gly Ile Asn Val Pro Val Gln Gly Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  31

Gly Ile Asp Ile Pro Thr Lys Gly Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  32

Gly Ile Asp Met Pro Thr Lys Gly Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  33

Gly Ile Asn Pro Ala Thr Arg Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  34

Gly Ile Asn Pro Ala Thr Lys Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  35

Gly Ile Asp Val Pro Val Arg Gly Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  36

Gly Ile Asn Pro Ala Thr Arg Ser Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  37

Gly Ile Asn Pro Ala Thr Asn Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR2

<400>  38

Gly Ile Asn Pro Ala Thr Met Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR3

<400>  39

Ala Leu Pro Arg Ser Gly Tyr Leu Met Lys Lys Asn Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR3

<400>  40

Ala Leu Pro Arg Ser Gly Tyr Leu Met Lys Thr Gly Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR3

<400>  41

Ala Leu Pro Arg Ser Gly Tyr Leu Val Lys Lys Gln Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR3

<400>  42

Ala Leu Pro Arg Ser Gly Tyr Leu Val Lys His Gly Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured HCDR3

<400>  43

Ala Leu Pro Arg Ser Gly Tyr Leu Met Lys Pro Gly Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  44
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR1

<400>  44

Ser Gly Ser Ser Glu Met Thr Val His His Tyr Val Tyr 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR1

<400>  45

Ser Gly Ser Ser Phe Ser His Pro His His Tyr Val Tyr 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR1

<400>  46

Ser Gly Ser Ser Glu Phe Val Glu Tyr Asn Tyr Val Tyr 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR1

<400>  47

Ser Gly Ser Ser Asp Thr Asn Ser His His Tyr Val Tyr 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR1

<400>  48

Ser Gly Ser Ser Trp Thr Glu Gln His Asn Tyr Val Tyr 
1               5                   10              


<210>  49
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR1

<400>  49

Ser Gly Ser Ser Val Met Val Thr Asn His Tyr Val Tyr 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR1

<400>  50

Ser Gly Ser Ser Gly Met Val Glu Gln Asn Tyr Val Tyr 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR1

<400>  51

Ser Gly Ser Ser Phe Lys Val Glu Glu Thr Tyr Val Tyr 
1               5                   10              


<210>  52
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  52

Ala Ser Trp Tyr Asn Asp Leu Arg Gly Val 
1               5                   10  


<210>  53
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  53

Ala Ser Trp Glu Ile Pro Leu Arg Gly Val 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  54

Ala Ser Trp Thr Asn Glu Leu Arg Gly Val 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  55

Ala Ser Trp Trp Asn Asp Leu Arg Gly Val 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  56

Ala Ser Trp Glu Leu Pro Leu Arg Gly Val 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  57

Ala Ser Trp Ser Ile Pro Leu Arg Gly Val 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  58

Ala Ser Trp Glu Val Pro Leu Arg Gly Val 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  59

Ala Ala Trp Asp Pro Gln Val Arg Leu Ala 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  60

Ala Ala Trp Asp Gln Gln Val Arg Leu Asp 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  61

Ala Ala Trp Asp Gln Gln Val Arg Lys Thr 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  62

Ala Ala Trp Asp Glu Arg Val Arg Leu Met 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured LCDR3

<400>  63

Ala Ala Trp Asp Asn Gln Val Arg Leu Gly 
1               5                   10  


<210>  64
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sequencing primer

<400>  64
gtccttgacc aggcagccca g                                               21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sequencing primer

<400>  65
gtgagttagc tcactcatta g                                               21


<210>  66
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sequencing primer

<400>  66
ttttcatcgg cattttcggt c                                               21


<210>  67
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Sequencing primer

<400>  67
ccatctgatg agcagttgaa atct                                            24


<210>  68
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Sequencing primer

<400>  68
gttcccgccc tcctctgagg agct                                            24


<210>  69
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Sequencing primer

<400>  69
agcggataac aatttcacac agg                                             23


<210>  70
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequencing primer

<400>  70
ggttctggca aatattctg                                                  19


<210>  71
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequencing primer

<400>  71
gttgcaccga ccgaatgta                                                  19


<210>  72
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Sequencing primer

<400>  72
accgtgagct ggaacagcgg tgcgc                                           25


<210>  73
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured vH region

<400>  73

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Ile Pro Thr Lys Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  74
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured vH region

<400>  74

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Val Pro Val Gln Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  75
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured vL region

<400>  75

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Glu Met Thr Val His His 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu 
                85                  90                  95      


Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120 


<210>  76
<211>  130
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured vH region

<400>  76

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Met Pro Thr Lys Gly Gly Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr 
            100                 105                 110         


Tyr Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  77
<211>  131
<212>  PRT
<213>  Artificial

<220>
<223>  Affinity-matured vH region

<400>  77

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Val Pro Leu Tyr Gly Gly Gly Thr Val Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His 
            100                 105                 110         


Tyr Tyr Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


