                         SEQUENCE LISTING

<110>  Amgen Inc.
 
<120>  APELIN ANTIGEN-BINDING PROTEINS AND USES THEREOF

<130>  A-1633-WO-PCT

<140>  Not Yet Known
<141>  2012-07-17

<150>  61/508,862
<151>  2011-07-18

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody light chain

<400>  1

Met Asp Ser Gln Ala Gln Val Leu Ile Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asp Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Ser Trp Ala Ser Ile Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Ser Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Lys Gln Ser Tyr Tyr Leu Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg 
    130             


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody light chain

<400>  2

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Ser Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Tyr Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  3
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asn Leu Arg Leu Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Leu Thr Ala Val Cys Gly Gly Ser Leu Met Pro Leu Pro Asp Gly Asn 
            20                  25                  30          


Gly Leu Glu Asp Gly Asn Val Arg His Leu Val Gln Pro Arg Gly Ser 
        35                  40                  45              


Arg Asn Gly Pro Gly Pro Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  


Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          


<210>  4
<211>  77
<212>  PRT
<213>  Mus musculus

<400>  4

Met Asn Leu Arg Leu Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Leu Thr Ala Val Cys Gly Val Pro Leu Met Leu Pro Pro Asp Gly Thr 
            20                  25                  30          


Gly Leu Glu Glu Gly Ser Met Arg Tyr Leu Val Lys Pro Arg Thr Ser 
        35                  40                  45              


Arg Thr Gly Pro Gly Ala Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  


Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          


<210>  5
<211>  77
<212>  PRT
<213>  Rattus rattus

<400>  5

Met Asn Leu Ser Phe Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Leu Thr Ala Val Cys Gly Val Pro Leu Met Leu Pro Pro Asp Gly Lys 
            20                  25                  30          


Gly Leu Glu Glu Gly Asn Met Arg Tyr Leu Val Lys Pro Arg Thr Ser 
        35                  40                  45              


Arg Thr Gly Pro Gly Ala Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  


Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          


<210>  6
<211>  77
<212>  PRT
<213>  Bos taurus

<400>  6

Met Asn Leu Arg Arg Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Cys 
1               5                   10                  15      


Leu Ser Ala Val Cys Gly Gly Pro Leu Leu Gln Thr Ser Asp Gly Lys 
            20                  25                  30          


Glu Met Glu Glu Gly Thr Ile Arg Tyr Leu Val Gln Pro Arg Gly Pro 
        35                  40                  45              


Arg Ser Gly Pro Gly Pro Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  


Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          


<210>  7
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Ala 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              


<210>  12
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10      


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10  


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser His Lys Gly Pro Met Pro Phe 
1               5               


<210>  16
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  16

His Lys Gly Pro Met Pro Phe 
1               5           


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro 
1               5                   10      


<210>  18
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Pro Arg Leu Ser His Lys Gly Pro Met 
1               5                   10  


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Pro Arg Leu Ser His Lys Gly Pro 
1               5                   


<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Pro Arg Leu Ser His Lys Gly 
1               5               


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Pro Arg Leu Ser His Lys 
1               5           


<210>  22
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Pro Gly Ala Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
1               5                   10                  


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR region

<400>  23

Lys Ser Ser Gln Ser Leu Leu Asp Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR region

<400>  24

Trp Ala Ser Ile Arg Glu Ser 
1               5           


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR region

<400>  25

Lys Gln Ser Tyr Tyr Leu Leu Thr 
1               5               


<210>  26
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody heavy chain

<400>  26

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asn Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe 
        35                  40                  45              


Ser Asp Tyr Val Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ile Tyr Thr Ser Tyr Pro 
65                  70                  75                  80  


Asp Asn Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn 
                85                  90                  95      


Lys Leu Tyr Leu Gln Met Ser His Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Phe Cys Ser Arg Ala Ala Ile Thr Ser Asp Asp Phe Asp Phe Trp 
        115                 120                 125             


Gly Gln Gly Thr Ala Leu Thr Val Ser Ser 
    130                 135             


<210>  27
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody heavy chain

<400>  27

Asn Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Gly Gly Ile Tyr Thr Ser Tyr Pro Asp Asn Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Lys Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser His Leu Arg Ser Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ser Arg Ala Ala Ile Thr Ser Asp Asp Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Ala Leu Thr Val Ser Ser 
        115                 


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR region

<400>  28

Asp Tyr Val Met Ser 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR region

<400>  29

Thr Ile Ser Asp Gly Gly Ile Tyr Thr Ser Tyr Pro Asp Asn Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR region

<400>  30

Ala Ala Ile Thr Ser Asp Asp Phe Asp Phe 
1               5                   10  


<210>  31
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              


<210>  32
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  32

Pro Arg Leu Ser His Lys Gly 
1               5           


