                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  OSCAR ANTAGONISTS

<130>  anti OSCAR

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  263
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Val Pro Pro Ala Ser Tyr His Pro Lys 
            20                  25                  30          


Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr Pro Gly Val Asn 
        35                  40                  45              


Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp Arg Phe Gly Leu 
    50                  55                  60                  


Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg Asp Val Ser Ser 
65                  70                  75                  80  


Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro Ala Gln Gly Gly 
                85                  90                  95      


Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly Pro Gly Val Trp 
            100                 105                 110         


Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr Glu Glu Leu Pro 
        115                 120                 125             


Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val Gly Pro Gly Ala 
    130                 135                 140                 


Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn Met Ser Phe Val 
145                 150                 155                 160 


Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr Arg His Ser Ala 
                165                 170                 175     


Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg Ala Pro Gly Thr 
            180                 185                 190         


Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr Val Leu Ser Gln 
        195                 200                 205             


Arg Ser Glu Val Leu Val Ile Ser Trp Glu Asp Ser Gly Ser Ser Asp 
    210                 215                 220                 


Tyr Thr Arg Gly Asn Leu Val Arg Leu Gly Leu Ala Gly Leu Val Leu 
225                 230                 235                 240 


Ile Ser Leu Gly Ala Leu Val Thr Phe Asp Trp Arg Ser Gln Asn Arg 
                245                 250                 255     


Ala Pro Ala Gly Ile Arg Pro 
            260             


<210>  2
<211>  209
<212>  PRT
<213>  HOMO SAPIENS

<400>  2

Asp Ile Thr Pro Ser Val Pro Pro Ala Ser Tyr His Pro Lys Pro Trp 
1               5                   10                  15      


Leu Gly Ala Gln Pro Ala Thr Val Val Thr Pro Gly Val Asn Val Thr 
            20                  25                  30          


Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp Arg Phe Gly Leu Phe Lys 
        35                  40                  45              


Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg Asp Val Ser Ser Glu Leu 
    50                  55                  60                  


Ala Glu Phe Phe Leu Glu Glu Val Thr Pro Ala Gln Gly Gly Ser Tyr 
65                  70                  75                  80  


Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly Pro Gly Val Trp Ser Gln 
                85                  90                  95      


Pro Ser Asp Val Leu Glu Leu Leu Val Thr Glu Glu Leu Pro Arg Pro 
            100                 105                 110         


Ser Leu Val Ala Leu Pro Gly Pro Val Val Gly Pro Gly Ala Asn Val 
        115                 120                 125             


Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn Met Ser Phe Val Leu Tyr 
    130                 135                 140                 


Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr Arg His Ser Ala Gln Pro 
145                 150                 155                 160 


Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg Ala Pro Gly Thr Tyr Ser 
                165                 170                 175     


Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr Val Leu Ser Gln Arg Ser 
            180                 185                 190         


Glu Val Leu Val Ile Ser Trp Glu Asp Ser Gly Ser Ser Asp Tyr Thr 
        195                 200                 205             


Arg 
    


<210>  3
<211>  264
<212>  PRT
<213>  homo sapiens

<400>  3

Asp Ile Thr Pro Ser Val Pro Pro Ala Ser Tyr His Pro Lys Pro Trp 
1               5                   10                  15      


Leu Gly Ala Gln Pro Ala Thr Val Val Thr Pro Gly Val Asn Val Thr 
            20                  25                  30          


Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp Arg Phe Gly Leu Phe Lys 
        35                  40                  45              


Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg Asp Val Ser Ser Glu Leu 
    50                  55                  60                  


Ala Glu Phe Phe Leu Glu Glu Val Thr Pro Ala Gln Gly Gly Ser Tyr 
65                  70                  75                  80  


Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly Pro Gly Val Trp Ser Gln 
                85                  90                  95      


Pro Ser Asp Val Leu Glu Leu Leu Val Thr Glu Glu Leu Pro Arg Pro 
            100                 105                 110         


Ser Leu Val Ala Leu Pro Gly Pro Val Val Gly Pro Gly Ala Asn Val 
        115                 120                 125             


Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn Met Ser Phe Val Leu Tyr 
    130                 135                 140                 


Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr Arg His Ser Ala Gln Pro 
145                 150                 155                 160 


Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg Ala Pro Gly Thr Tyr Ser 
                165                 170                 175     


Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr Val Leu Ser Gln Arg Ser 
            180                 185                 190         


Glu Val Leu Val Ile Ser Trp Glu Gly Glu Gly Pro Glu Ala Arg Pro 
        195                 200                 205             


Ala Ser Ser Ala Pro Gly Met Gln Ala Pro Gly Pro Pro Pro Ser Asp 
    210                 215                 220                 


Pro Gly Ala Gln Ala Pro Ser Leu Ser Ser Phe Arg Pro Arg Gly Leu 
225                 230                 235                 240 


Val Leu Gln Pro Leu Leu Pro Gln Thr Gln Asp Ser Trp Asp Pro Ala 
                245                 250                 255     


Pro Pro Pro Ser Asp Pro Gly Val 
            260                 


<210>  4
<211>  268
<212>  PRT
<213>  homo sapiens

<400>  4

Asp Ile Thr Pro Ser Val Ala Ile Ile Val Pro Pro Ala Ser Tyr His 
1               5                   10                  15      


Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr Pro Gly 
            20                  25                  30          


Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp Arg Phe 
        35                  40                  45              


Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg Asp Val 
    50                  55                  60                  


Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro Ala Gln 
65                  70                  75                  80  


Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly Pro Gly 
                85                  90                  95      


Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr Glu Glu 
            100                 105                 110         


Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val Gly Pro 
        115                 120                 125             


Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn Met Ser 
    130                 135                 140                 


Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr Arg His 
145                 150                 155                 160 


Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg Ala Pro 
                165                 170                 175     


Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr Val Leu 
            180                 185                 190         


Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Gly Glu Gly Pro 
        195                 200                 205             


Glu Ala Arg Pro Ala Ser Ser Ala Pro Gly Met Gln Ala Pro Gly Pro 
    210                 215                 220                 


Pro Pro Ser Asp Pro Gly Ala Gln Ala Pro Ser Leu Ser Ser Phe Arg 
225                 230                 235                 240 


Pro Arg Gly Leu Val Leu Gln Pro Leu Leu Pro Gln Thr Gln Asp Ser 
                245                 250                 255     


Trp Asp Pro Ala Pro Pro Pro Ser Asp Pro Gly Val 
            260                 265             


<210>  5
<211>  232
<212>  PRT
<213>  artificial

<220>
<223>  7F1A1 Light Chain

<400>  5

Met Lys Leu Pro Val Arg Leu Leu Val Leu Leu Trp Leu Thr Asp Ala 
1               5                   10                  15      


Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser 
            20                  25                  30          


Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Lys Ile Tyr 
        35                  40                  45              


Ser Asn Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu 
    50                  55                  60                  


Leu Val Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu 
                85                  90                  95      


Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Ile 
            100                 105                 110         


Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
        115                 120                 125             


Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr 
    130                 135                 140                 


Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys 
145                 150                 155                 160 


Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly 
                165                 170                 175     


Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn 
        195                 200                 205             


Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val 
    210                 215                 220                 


Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230         


<210>  6
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  7F1A1 Heavy Chain

<400>  6

Met Gly Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Asn Tyr Met Ile Glu Trp Val Lys Lys Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Glu Asn Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Leu Asp Phe Asp Gly Ala Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
145                 150                 155                 160 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
225                 230                 235                 240 


Cys 
    


<210>  7
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  7F6A1 Light Chain

<400>  7

Met Asp Leu Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Glu Asn Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Ile Ser Tyr Met His Trp Tyr Arg Gln Lys Ser Phe Thr Ser 
    50                  55                  60                  


Pro Gln Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Ser Gly Ser Gly Ile Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly 
            100                 105                 110         


Ser Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 


<210>  8
<211>  238
<212>  PRT
<213>  artificial

<220>
<223>  7F6A1 Heavy chain

<400>  8

Met Asp Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Val Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Glu Gly Gly Asn Ser Pro Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235             


<210>  9
<211>  238
<212>  PRT
<213>  artificial

<220>
<223>  7F9A1 Light Chain

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Thr Ser Asn Ser Ser Tyr Met His Trp Cys Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln His Ser Trp Glu Ile Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  10
<211>  242
<212>  PRT
<213>  artificial

<220>
<223>  7F9A1 Heavy Chain

<400>  10

Met Glu Trp Ser Trp Val Phe Ile Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Gly Asn Tyr Asp Trp Trp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys 
        


<210>  11
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  7F10A1 Light Chain

<400>  11

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Leu Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Phe Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Ile Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg 
            100                 105                 110         


Ser Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 


<210>  12
<211>  242
<212>  PRT
<213>  artificial

<220>
<223>  7F10A1 Heavy Chain

<400>  12

Met Gly Trp Ser Trp Val Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Asn Tyr Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Ala Asn Arg Tyr Asp Arg Gly Asp Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Pro Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys 
        


<210>  13
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  7F14A1 Light Chain

<400>  13

Met Asp Phe Gln Val Gln Ile Ile Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Ile Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Asn Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
    50                  55                  60                  


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Thr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 


<210>  14
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  7F14A1 Heavy Chain

<400>  14

Arg Leu Trp Leu Val Leu Gly Leu Leu Phe Cys Leu Val Ala Phe Pro 
1               5                   10                  15      


Ser Cys Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Ser Val Ser Gly Phe 
        35                  40                  45              


Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Val Met Trp Ala Gly Gly Ser Thr Asn Tyr 
65                  70                  75                  80  


Asn Ser Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys 
                85                  90                  95      


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Ser Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Leu Gln Lys Gly Tyr Gly Asn Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
145                 150                 155                 160 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
225                 230                 235                 240 


Cys 
    


<210>  15
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  7F21A1 Light Chain

<400>  15

Met Ser Val Leu Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Val Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Lys 
        35                  40                  45              


Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Val Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn 
                85                  90                  95      


Asn Leu Gln Ser Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp 
            100                 105                 110         


Gly Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  16
<211>  241
<212>  PRT
<213>  artificial

<220>
<223>  7F21A1 Heavy Chain

<400>  16

Met Gly Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Arg Ser Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Asn Tyr Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Thr Pro Gly Ser Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Asn Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Thr Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Phe Asp Tyr Asp Gly Ala Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
145                 150                 155                 160 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
225                 230                 235                 240 


Cys 
    


<210>  17
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  4F3B Light Chain

<400>  17

Met Glu Ser Gln Ile Leu Val Leu Met Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr 
            20                  25                  30          


Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 240 


<210>  18
<211>  238
<212>  PRT
<213>  artificial

<220>
<223>  4F3B Heavy Chain

<400>  18

Met Gly Trp Ser Gly Ile Phe Ile Phe Leu Phe Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Asp Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Ser Pro Phe Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235             


<210>  19
<211>  234
<212>  PRT
<213>  artificial

<220>
<223>  3F7A9-1 Light Chain

<400>  19

Met Arg Ala Pro Ala Gln Ile Leu Gly Ile Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Ser Phe Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asp Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  20
<211>  238
<212>  PRT
<213>  artificial

<220>
<223>  3F7A9 Heavy Chain

<400>  20

Met Gly Trp Ser Gly Val Phe Leu Phe Leu Leu Ser Gly Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Val Phe 
        35                  40                  45              


Thr Ser Tyr Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Asp Tyr Tyr Gly Asn Phe Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235             


<210>  21
<211>  109
<212>  PRT
<213>  artificial

<220>
<223>  13F5A5 Variable Light Chain

<400>  21

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  22
<211>  128
<212>  PRT
<213>  artificial

<220>
<223>  13F5A5 Variable Heavy Chain

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Val Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Tyr Pro Gly Asp Ser Asp Ala Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Ile Thr Met Val Arg Gly Val Ile Ile Thr Pro Leu 
            100                 105                 110         


Asp Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  23
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  13F56 Variable Light Chain

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105             


<210>  24
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  13F56 Variable Heavy Chain

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Lys Ile Ile Pro Ile Leu Gly Ile Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Pro Leu Thr Phe Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  25
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  16F56 Variable Light Chain

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Gly Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  26
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  16F56 Variable Heavy Chain

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala His Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Ser Ser Gly Lys Gly Leu Pro Tyr Trp Phe Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  27
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  16F119 Variable Light Chain

<400>  27

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  28
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  16F56 Variable Heavy Chain

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Ala Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Ile Thr Ala Asp Lys Phe Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gln Leu Gly Thr Pro Tyr Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  6F3A Variable Light Chain

<400>  29

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Thr Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  30
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  6F3A Variable Heavy Chain

<400>  30

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Val His Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ile Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Ile Thr Ala Asp Ser Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Tyr Gly Asn Tyr Gly Leu Asp Tyr Ser Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


