                         SEQUENCE LISTING

<110>  Memorial Sloan-Kettering Cancer Center
       Nimer, Stephen
       Wang, Lan
 
<120>  METHOD OF TREATING AND REDUCING THE RISK OF ACUTE MYELOGENOUS 
       LEUKEMIA

<130>  2003080-0471

<150>  61/572,321
<151>  2011-07-14

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  752
<212>  PRT
<213>  Homo sapiens


<220>
<221>  ACT_SITE
<222>  (24)..(24)
<223>  This site may or may not be acetylated.

<220>
<221>  ACT_SITE
<222>  (43)..(43)
<223>  This site may or may not be acetylated.

<400>  1

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Asn Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp 
            180                 185                 190         


Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro 
        195                 200                 205             


Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu 
    210                 215                 220                 


Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser 
225                 230                 235                 240 


Pro Pro Asn Gly Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser 
                245                 250                 255     


Leu Ala Asn Gln Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser 
            260                 265                 270         


Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile 
        275                 280                 285             


Ser Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val 
    290                 295                 300                 


Asn Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala 
305                 310                 315                 320 


Thr Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn 
                325                 330                 335     


Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys 
            340                 345                 350         


Gln Asn Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp 
        355                 360                 365             


Ala Ser Thr Thr Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val 
    370                 375                 380                 


Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly 
385                 390                 395                 400 


Phe Asp Arg Glu Pro Leu His Ser Glu His Pro Ser Lys Arg Pro Cys 
                405                 410                 415     


Thr Ile Ser Pro Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr 
            420                 425                 430         


Gln Pro Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr 
        435                 440                 445             


Arg Leu Asp Asp Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg 
    450                 455                 460                 


His Pro Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu 
465                 470                 475                 480 


His Gly Thr Arg Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp Arg 
                485                 490                 495     


Glu Trp Ala Glu Glu Trp Lys His Leu Asp His Leu Leu Asn Cys Ile 
            500                 505                 510         


Met Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg 
        515                 520                 525             


Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg Tyr 
    530                 535                 540                 


Ser Asp Ala Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His 
545                 550                 555                 560 


Ser Arg Gln Gln Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp Ala 
                565                 570                 575     


His Arg Glu Phe Leu His Arg Pro Ala Ser Gly Tyr Val Pro Glu Glu 
            580                 585                 590         


Ile Trp Lys Lys Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala 
        595                 600                 605             


Met Thr Glu Leu Gln Lys Ala Val Ser Glu Ala Glu Arg Lys Ala His 
    610                 615                 620                 


Asp Met Ile Thr Thr Glu Arg Ala Lys Met Glu Arg Thr Val Ala Glu 
625                 630                 635                 640 


Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val Ile Asn Gln Gln 
                645                 650                 655     


Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu 
            660                 665                 670         


Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys Gln 
        675                 680                 685             


His Lys Asp Trp Glu Lys His His His Ile Cys Gly Gln Thr Leu Gln 
    690                 695                 700                 


Ala Gln Gln Gln Gly Asp Thr Pro Ala Val Ser Ser Ser Val Thr Pro 
705                 710                 715                 720 


Asn Ser Gly Ala Gly Ser Pro Met Asp Thr Pro Pro Ala Ala Thr Pro 
                725                 730                 735     


Arg Ser Thr Thr Pro Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro Arg 
            740                 745                 750         


<210>  2
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human AML1-ETO delta NHR1

<400>  2

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Asn Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp 
            180                 185                 190         


Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro 
        195                 200                 205             


Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu 
    210                 215                 220                 


Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser 
225                 230                 235                 240 


Pro Pro Asn Gly Phe Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro 
                245                 250                 255     


Met Gly Leu His Gly Thr Arg Gln Glu Glu Met Ile Asp His Arg Leu 
            260                 265                 270         


Thr Asp Arg Glu Trp Ala Glu Glu Trp Lys His Leu Asp His Leu Leu 
        275                 280                 285             


Asn Cys Ile Met Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val 
    290                 295                 300                 


Leu Arg Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn Tyr Trp Ile 
305                 310                 315                 320 


Arg Arg Tyr Ser Asp Ala Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser 
                325                 330                 335     


Ser Ser His Ser Arg Gln Gln Ser Pro Val Asn Pro Asp Pro Val Ala 
            340                 345                 350         


Leu Asp Ala His Arg Glu Phe Leu His Arg Pro Ala Ser Gly Tyr Val 
        355                 360                 365             


Pro Glu Glu Ile Trp Lys Lys Ala Glu Glu Ala Val Asn Glu Val Lys 
    370                 375                 380                 


Arg Gln Ala Met Thr Glu Leu Gln Lys Ala Val Ser Glu Ala Glu Arg 
385                 390                 395                 400 


Lys Ala His Asp Met Ile Thr Thr Glu Arg Ala Lys Met Glu Arg Thr 
                405                 410                 415     


Val Ala Glu Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val Ile 
            420                 425                 430         


Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys 
        435                 440                 445             


Ala Ser Glu Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly Ser 
    450                 455                 460                 


Phe Cys Gln His Lys Asp Trp Glu Lys His His His Ile Cys Gly Gln 
465                 470                 475                 480 


Thr Leu Gln Ala Gln Gln Gln Gly Asp Thr Pro Ala Val Ser Ser Ser 
                485                 490                 495     


Val Thr Pro Asn Ser Gly Ala Gly Ser Pro Met Asp Thr Pro Pro Ala 
            500                 505                 510         


Ala Thr Pro Arg Ser Thr Thr Pro Gly Thr Pro Ser Thr Ile Glu Thr 
        515                 520                 525             


Thr Pro Arg 
    530     


<210>  3
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human AML1-ETO delta NHR2

<400>  3

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Asn Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp 
            180                 185                 190         


Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro 
        195                 200                 205             


Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu 
    210                 215                 220                 


Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser 
225                 230                 235                 240 


Pro Pro Asn Gly Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser 
                245                 250                 255     


Leu Ala Asn Gln Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser 
            260                 265                 270         


Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile 
        275                 280                 285             


Ser Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val 
    290                 295                 300                 


Asn Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala 
305                 310                 315                 320 


Thr Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn 
                325                 330                 335     


Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys 
            340                 345                 350         


Gln Asn Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp 
        355                 360                 365             


Ala Ser Thr Thr Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val 
    370                 375                 380                 


Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly 
385                 390                 395                 400 


Phe Asp Arg Glu Pro Leu His Ser Glu His Pro Ser Lys Arg Pro Cys 
                405                 410                 415     


Thr Ile Ser Pro Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr 
            420                 425                 430         


Gln Pro Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr 
        435                 440                 445             


Arg Leu Asp Asp Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg 
    450                 455                 460                 


His Pro Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu 
465                 470                 475                 480 


Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His Ser Arg Gln 
                485                 490                 495     


Gln Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp Ala His Arg Glu 
            500                 505                 510         


Phe Leu His Arg Pro Ala Ser Gly Tyr Val Pro Glu Glu Ile Trp Lys 
        515                 520                 525             


Lys Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala Met Thr Glu 
    530                 535                 540                 


Leu Gln Lys Ala Val Ser Glu Ala Glu Arg Lys Ala His Asp Met Ile 
545                 550                 555                 560 


Thr Thr Glu Arg Ala Lys Met Glu Arg Thr Val Ala Glu Ala Lys Arg 
                565                 570                 575     


Gln Ala Ala Glu Asp Ala Leu Ala Val Ile Asn Gln Gln Glu Asp Ser 
            580                 585                 590         


Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu Thr Cys Ser 
        595                 600                 605             


Gly Cys Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys Gln His Lys Asp 
    610                 615                 620                 


Trp Glu Lys His His His Ile Cys Gly Gln Thr Leu Gln Ala Gln Gln 
625                 630                 635                 640 


Gln Gly Asp Thr Pro Ala Val Ser Ser Ser Val Thr Pro Asn Ser Gly 
                645                 650                 655     


Ala Gly Ser Pro Met Asp Thr Pro Pro Ala Ala Thr Pro Arg Ser Thr 
            660                 665                 670         


Thr Pro Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro Arg 
        675                 680                 685 


<210>  4
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human AML1-ETO delta Runt

<400>  4

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Lys His Ser Thr Met Pro Asp Ser Pro Val Asp Val Lys Thr Gln Ser 
    50                  55                  60                  


Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro Thr Thr Gln Gly Ala 
65                  70                  75                  80  


Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu Thr Asn Gly Thr Ser 
                85                  90                  95      


His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser Pro Pro Asn Gly Phe 
            100                 105                 110         


Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser Leu Ala Asn Gln Gln 
        115                 120                 125             


Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg Phe 
    130                 135                 140                 


Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile Gly 
145                 150                 155                 160 


Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val Asn Ser Thr Leu Thr 
                165                 170                 175     


Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala Thr Asn Phe Pro Leu 
            180                 185                 190         


Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu Gln 
        195                 200                 205             


Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys Gln Asn Pro Ala Gln 
    210                 215                 220                 


Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp Ala Ser Thr Thr Ser 
225                 230                 235                 240 


Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val Asn Glu Asn Gly Lys 
                245                 250                 255     


Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly Phe Asp Arg Glu Pro 
            260                 265                 270         


Leu His Ser Glu His Pro Ser Lys Arg Pro Cys Thr Ile Ser Pro Gly 
        275                 280                 285             


Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr Gln Pro Asn Gly Leu 
    290                 295                 300                 


Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr Arg Leu Asp Asp Met 
305                 310                 315                 320 


Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg His Pro Ser His Arg 
                325                 330                 335     


Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu His Gly Thr Arg Gln 
            340                 345                 350         


Glu Glu Met Ile Asp His Arg Leu Thr Asp Arg Glu Trp Ala Glu Glu 
        355                 360                 365             


Trp Lys His Leu Asp His Leu Leu Asn Cys Ile Met Asp Met Val Glu 
    370                 375                 380                 


Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg Cys Gln Glu Ala Asp 
385                 390                 395                 400 


Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg Tyr Ser Asp Ala Glu Asp 
                405                 410                 415     


Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His Ser Arg Gln Gln Ser 
            420                 425                 430         


Pro Val Asn Pro Asp Pro Val Ala Leu Asp Ala His Arg Glu Phe Leu 
        435                 440                 445             


His Arg Pro Ala Ser Gly Tyr Val Pro Glu Glu Ile Trp Lys Lys Ala 
    450                 455                 460                 


Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala Met Thr Glu Leu Gln 
465                 470                 475                 480 


Lys Ala Val Ser Glu Ala Glu Arg Lys Ala His Asp Met Ile Thr Thr 
                485                 490                 495     


Glu Arg Ala Lys Met Glu Arg Thr Val Ala Glu Ala Lys Arg Gln Ala 
            500                 505                 510         


Ala Glu Asp Ala Leu Ala Val Ile Asn Gln Gln Glu Asp Ser Ser Glu 
        515                 520                 525             


Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu Thr Cys Ser Gly Cys 
    530                 535                 540                 


Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys Gln His Lys Asp Trp Glu 
545                 550                 555                 560 


Lys His His His Ile Cys Gly Gln Thr Leu Gln Ala Gln Gln Gln Gly 
                565                 570                 575     


Asp Thr Pro Ala Val Ser Ser Ser Val Thr Pro Asn Ser Gly Ala Gly 
            580                 585                 590         


Ser Pro Met Asp Thr Pro Pro Ala Ala Thr Pro Arg Ser Thr Thr Pro 
        595                 600                 605             


Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro Arg 
    610                 615                 


<210>  5
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human AML1-ETO K24R

<400>  5

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Arg Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Asn Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp 
            180                 185                 190         


Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro 
        195                 200                 205             


Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu 
    210                 215                 220                 


Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser 
225                 230                 235                 240 


Pro Pro Asn Gly Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser 
                245                 250                 255     


Leu Ala Asn Gln Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser 
            260                 265                 270         


Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile 
        275                 280                 285             


Ser Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val 
    290                 295                 300                 


Asn Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala 
305                 310                 315                 320 


Thr Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn 
                325                 330                 335     


Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys 
            340                 345                 350         


Gln Asn Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp 
        355                 360                 365             


Ala Ser Thr Thr Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val 
    370                 375                 380                 


Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly 
385                 390                 395                 400 


Phe Asp Arg Glu Pro Leu His Ser Glu His Pro Ser Lys Arg Pro Cys 
                405                 410                 415     


Thr Ile Ser Pro Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr 
            420                 425                 430         


Gln Pro Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr 
        435                 440                 445             


Arg Leu Asp Asp Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg 
    450                 455                 460                 


His Pro Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu 
465                 470                 475                 480 


His Gly Thr Arg Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp Arg 
                485                 490                 495     


Glu Trp Ala Glu Glu Trp Lys His Leu Asp His Leu Leu Asn Cys Ile 
            500                 505                 510         


Met Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg 
        515                 520                 525             


Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg Tyr 
    530                 535                 540                 


Ser Asp Ala Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His 
545                 550                 555                 560 


Ser Arg Gln Gln Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp Ala 
                565                 570                 575     


His Arg Glu Phe Leu His Arg Pro Ala Ser Gly Tyr Val Pro Glu Glu 
            580                 585                 590         


Ile Trp Lys Lys Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala 
        595                 600                 605             


Met Thr Glu Leu Gln Lys Ala Val Ser Glu Ala Glu Arg Lys Ala His 
    610                 615                 620                 


Asp Met Ile Thr Thr Glu Arg Ala Lys Met Glu Arg Thr Val Ala Glu 
625                 630                 635                 640 


Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val Ile Asn Gln Gln 
                645                 650                 655     


Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu 
            660                 665                 670         


Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys Gln 
        675                 680                 685             


His Lys Asp Trp Glu Lys His His His Ile Cys Gly Gln Thr Leu Gln 
    690                 695                 700                 


Ala Gln Gln Gln Gly Asp Thr Pro Ala Val Ser Ser Ser Val Thr Pro 
705                 710                 715                 720 


Asn Ser Gly Ala Gly Ser Pro Met Asp Thr Pro Pro Ala Ala Thr Pro 
                725                 730                 735     


Arg Ser Thr Thr Pro Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro Arg 
            740                 745                 750         


<210>  6
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human AML1-ETO K43R

<400>  6

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Arg Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Asn Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp 
            180                 185                 190         


Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro 
        195                 200                 205             


Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu 
    210                 215                 220                 


Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser 
225                 230                 235                 240 


Pro Pro Asn Gly Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser 
                245                 250                 255     


Leu Ala Asn Gln Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser 
            260                 265                 270         


Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile 
        275                 280                 285             


Ser Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val 
    290                 295                 300                 


Asn Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala 
305                 310                 315                 320 


Thr Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn 
                325                 330                 335     


Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys 
            340                 345                 350         


Gln Asn Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp 
        355                 360                 365             


Ala Ser Thr Thr Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val 
    370                 375                 380                 


Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly 
385                 390                 395                 400 


Phe Asp Arg Glu Pro Leu His Ser Glu His Pro Ser Lys Arg Pro Cys 
                405                 410                 415     


Thr Ile Ser Pro Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr 
            420                 425                 430         


Gln Pro Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr 
        435                 440                 445             


Arg Leu Asp Asp Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg 
    450                 455                 460                 


His Pro Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu 
465                 470                 475                 480 


His Gly Thr Arg Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp Arg 
                485                 490                 495     


Glu Trp Ala Glu Glu Trp Lys His Leu Asp His Leu Leu Asn Cys Ile 
            500                 505                 510         


Met Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg 
        515                 520                 525             


Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg Tyr 
    530                 535                 540                 


Ser Asp Ala Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His 
545                 550                 555                 560 


Ser Arg Gln Gln Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp Ala 
                565                 570                 575     


His Arg Glu Phe Leu His Arg Pro Ala Ser Gly Tyr Val Pro Glu Glu 
            580                 585                 590         


Ile Trp Lys Lys Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala 
        595                 600                 605             


Met Thr Glu Leu Gln Lys Ala Val Ser Glu Ala Glu Arg Lys Ala His 
    610                 615                 620                 


Asp Met Ile Thr Thr Glu Arg Ala Lys Met Glu Arg Thr Val Ala Glu 
625                 630                 635                 640 


Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val Ile Asn Gln Gln 
                645                 650                 655     


Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu 
            660                 665                 670         


Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys Gln 
        675                 680                 685             


His Lys Asp Trp Glu Lys His His His Ile Cys Gly Gln Thr Leu Gln 
    690                 695                 700                 


Ala Gln Gln Gln Gly Asp Thr Pro Ala Val Ser Ser Ser Val Thr Pro 
705                 710                 715                 720 


Asn Ser Gly Ala Gly Ser Pro Met Asp Thr Pro Pro Ala Ala Thr Pro 
                725                 730                 735     


Arg Ser Thr Thr Pro Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro Arg 
            740                 745                 750         


<210>  7
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human AML1-ETO K24R K43R

<400>  7

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Arg Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Arg Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Asn Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp 
            180                 185                 190         


Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro 
        195                 200                 205             


Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu 
    210                 215                 220                 


Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser 
225                 230                 235                 240 


Pro Pro Asn Gly Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser 
                245                 250                 255     


Leu Ala Asn Gln Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser 
            260                 265                 270         


Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile 
        275                 280                 285             


Ser Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val 
    290                 295                 300                 


Asn Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala 
305                 310                 315                 320 


Thr Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn 
                325                 330                 335     


Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys 
            340                 345                 350         


Gln Asn Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp 
        355                 360                 365             


Ala Ser Thr Thr Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val 
    370                 375                 380                 


Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly 
385                 390                 395                 400 


Phe Asp Arg Glu Pro Leu His Ser Glu His Pro Ser Lys Arg Pro Cys 
                405                 410                 415     


Thr Ile Ser Pro Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr 
            420                 425                 430         


Gln Pro Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr 
        435                 440                 445             


Arg Leu Asp Asp Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg 
    450                 455                 460                 


His Pro Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu 
465                 470                 475                 480 


His Gly Thr Arg Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp Arg 
                485                 490                 495     


Glu Trp Ala Glu Glu Trp Lys His Leu Asp His Leu Leu Asn Cys Ile 
            500                 505                 510         


Met Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg 
        515                 520                 525             


Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg Tyr 
    530                 535                 540                 


Ser Asp Ala Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His 
545                 550                 555                 560 


Ser Arg Gln Gln Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp Ala 
                565                 570                 575     


His Arg Glu Phe Leu His Arg Pro Ala Ser Gly Tyr Val Pro Glu Glu 
            580                 585                 590         


Ile Trp Lys Lys Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala 
        595                 600                 605             


Met Thr Glu Leu Gln Lys Ala Val Ser Glu Ala Glu Arg Lys Ala His 
    610                 615                 620                 


Asp Met Ile Thr Thr Glu Arg Ala Lys Met Glu Arg Thr Val Ala Glu 
625                 630                 635                 640 


Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val Ile Asn Gln Gln 
                645                 650                 655     


Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu 
            660                 665                 670         


Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys Gln 
        675                 680                 685             


His Lys Asp Trp Glu Lys His His His Ile Cys Gly Gln Thr Leu Gln 
    690                 695                 700                 


Ala Gln Gln Gln Gly Asp Thr Pro Ala Val Ser Ser Ser Val Thr Pro 
705                 710                 715                 720 


Asn Ser Gly Ala Gly Ser Pro Met Asp Thr Pro Pro Ala Ala Thr Pro 
                725                 730                 735     


Arg Ser Thr Thr Pro Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro Arg 
            740                 745                 750         


<210>  8
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human AML1-ETO 9a

<400>  8

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Asn Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp 
            180                 185                 190         


Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro 
        195                 200                 205             


Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu 
    210                 215                 220                 


Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser 
225                 230                 235                 240 


Pro Pro Asn Gly Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser 
                245                 250                 255     


Leu Ala Asn Gln Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser 
            260                 265                 270         


Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile 
        275                 280                 285             


Ser Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val 
    290                 295                 300                 


Asn Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala 
305                 310                 315                 320 


Thr Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn 
                325                 330                 335     


Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys 
            340                 345                 350         


Gln Asn Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp 
        355                 360                 365             


Ala Ser Thr Thr Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val 
    370                 375                 380                 


Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly 
385                 390                 395                 400 


Phe Asp Arg Glu Pro Leu His Ser Glu His Pro Ser Lys Arg Pro Cys 
                405                 410                 415     


Thr Ile Ser Pro Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr 
            420                 425                 430         


Gln Pro Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr 
        435                 440                 445             


Arg Leu Asp Asp Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg 
    450                 455                 460                 


His Pro Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu 
465                 470                 475                 480 


His Gly Thr Arg Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp Arg 
                485                 490                 495     


Glu Trp Ala Glu Glu Trp Lys His Leu Asp His Leu Leu Asn Cys Ile 
            500                 505                 510         


Met Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg 
        515                 520                 525             


Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg Tyr 
    530                 535                 540                 


Ser Asp Ala Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His 
545                 550                 555                 560 


Ser Arg Gln Gln Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp 
                565                 570                 575 


<210>  9
<211>  4272
<212>  DNA
<213>  Homo sapiens

<400>  9
catagagcca gcgggcgcgg gcgggacggg cgccccgcgg ccggacccag ccagggcacc       60

acgctgcccg gccctgcgcc gccaggcact tctttccggg gctcctaggg acgccagaag      120

gaagtcaacc tctgctgctt ctccttggcc tgcgttggac cttccttttt ttgttgtttt      180

tttttgtttt tcccctttct tccttttgaa ttaactggct tcttggctgg atgttttcaa      240

cttctttcct ggctgcgaac ttttccccaa ttgttttcct tttacaacag ggggagaaag      300

tgctctgtgg tccgaggcga gccgtgaagt tgcgtgtgcg tggcagtgtg cgtggcagga      360

tgtgcgtgcg tgtgtaaccc gagccgcccg atctgtttcg atctgcgccg cggagccctc      420

cctcaaggcc cgctccacct gctgcggtta cgcggcgctc gtgggtgttc gtgcctcgga      480

gcagctaacc ggcgggtgct gggcgacggt ggaggagtat cgtctcgctg ctgcccgagt      540

cagggctgag tcacccagct gatgtagaca gtggctgcct tccgaagagt gcgtgtttgc      600

atgtgtgtga ctctgcggct gctcaactcc caacaaacca gaggaccagc cacaaactta      660

accaacatcc ccaaacccga gttcacagat gtgggagagc tgtagaaccc tgagtgtcat      720

cgactgggcc ttcttatgat tgttgtttta agattagctg aagatctctg aaacgctgaa      780

ttttctgcac tgagcgtttt gacagaattc attgagagaa cagagaacat gacaagtact      840

tctagctcag cactgctcca actactgaag ctgattttca aggctactta aaaaaatctg      900

cagcgtacat taatggattt ctgttgtgtt taaattctcc acagattgta ttgtaaatat      960

tttatgaagt agagcatatg tatatattta tatatacgtg cacatacatt agtagcacta     1020

cctttggaag tctcagctct tgcttttcgg gactgaagcc agttttgcat gataaaagtg     1080

gccttgttac gggagataat tgtgttctgt tgggacttta gacaaaactc acctgcaaaa     1140

aactgacagg cattaactac tggaacttcc aaataatgtg tttgctgatc gttttactct     1200

tcgcataaat attttaggaa gtgtatgaga attttgcctt caggaacttt tctaacagcc     1260

aaagacagaa cttaacctct gcaagcaaga ttcgtggaag atagtctcca ctttttaatg     1320

cactaagcaa tcggttgcta ggagcccatc ctgggtcaga ggccgatccg cagaaccaga     1380

acgttttccc ctcctggact gttagtaact tagtctccct cctcccctaa ccacccccgc     1440

ccccccccac cccccgcagt aataaaggcc cctgaacgtg tatgttggtc tcccgggagc     1500

tgcttgctga agatccgcgc ccctgtcgcc gtctggtagg agctgtttgc agggtcctaa     1560

ctcaatcggc ttgttgtgat gcgtatcccc gtagatgcca gcacgagccg ccgcttcacg     1620

ccgccttcca ccgcgctgag cccaggcaag atgagcgagg cgttgccgct gggcgccccg     1680

gacgccggcg ctgccctggc cggcaagctg aggagcggcg accgcagcat ggtggaggtg     1740

ctggccgacc acccgggcga gctggtgcgc accgacagcc ccaacttcct ctgctccgtg     1800

ctgcctacgc actggcgctg caacaagacc ctgcccatcg ctttcaaggt ggtggcccta     1860

ggggatgttc cagatggcac tctggtcact gtgatggctg gcaatgatga aaactactcg     1920

gctgagctga gaaatgctac cgcagccatg aagaaccagg ttgcaagatt taatgacctc     1980

aggtttgtcg gtcgaagtgg aagagggaaa agcttcactc tgaccatcac tgtcttcaca     2040

aacccaccgc aagtcgccac ctaccacaga gccatcaaaa tcacagtgga tgggccccga     2100

gaacctcgaa atcgtactga gaagcactcc acaatgccag actcacctgt ggatgtgaag     2160

acgcaatcta ggctgactcc tccaacaatg ccacctcccc caactactca aggagctcca     2220

agaaccagtt catttacacc gacaacgtta actaatggca cgagccattc tcctacagcc     2280

ttgaatggcg ccccctcacc acccaatggc ttcagcaatg ggccttcctc ttcttcctcc     2340

tcctctctgg ctaatcaaca gctgccccca gcctgtggtg ccaggcaact cagcaagctg     2400

aaaaggttcc ttactaccct gcagcagttt ggcaatgaca tttcacccga gataggagaa     2460

agagttcgca ccctcgttct gggactagtg aactccactt tgacaattga agaatttcat     2520

tccaaactgc aagaagctac taacttccca ctgagacctt ttgtcatccc atttttgaag     2580

gccaacttgc ccctgctgca gcgtgagctc ctccactgcg caagactggc caaacagaac     2640

cctgcccagt acctcgccca gcatgaacag ctgcttctgg atgccagcac cacctcacct     2700

gttgactcct cagagctgct tctcgatgtg aacgaaaacg ggaagaggcg aactccagac     2760

agaaccaaag aaaatggctt tgacagagag cctttgcact cagaacatcc aagcaagcga     2820

ccatgcacta ttagcccagg ccagcggtac agtccaaata acggcttatc ctaccagccc     2880

aatggcctgc ctcaccctac cccacctcca cctcagcatt accgtttgga tgatatggcc     2940

attgcccacc actacaggga ctcctatcga caccccagcc acagggacct cagggacaga     3000

aacagaccta tggggttgca tggcacacgt caagaagaaa tgattgatca cagactaaca     3060

gacagagaat gggcagaaga gtggaaacat cttgaccatc tgttaaactg cataatggac     3120

atggtagaaa aaacaaggcg atctctcacc gtactaaggc ggtgtcaaga agcagaccgg     3180

gaagaattga attactggat ccggcggtac agtgacgccg aggacttaaa aaaaggtggc     3240

ggcagtagca gcagccactc taggcagcag agtcccgtca acccagaccc agttgcacta     3300

gacgcgcatc gggaattcct tcacaggcct gcgtctggat acgtgccaga ggagatctgg     3360

aagaaagctg aggaggccgt caatgaggtg aagcgccagg cgatgacgga gctgcagaag     3420

gccgtgtctg aggcggagcg gaaagcccac gacatgatca caacagagag ggccaagatg     3480

gagcgcacgg tcgccgaggc caaacggcag gcggcggagg acgcactggc agttatcaat     3540

cagcaggagg attcaagcga gagttgctgg aattgtggcc gtaaagcgag tgaaacctgc     3600

agtggctgta acacagcccg atactgtggc tcattttgcc agcacaaaga ctgggagaag     3660

caccatcaca tctgtggaca gaccctgcag gcccagcagc agggagacac acctgcagtc     3720

agctcctctg tcacgcccaa cagcggggct gggagcccga tggacacacc accagcagcc     3780

actccgaggt caaccacccc gggaacccct tccaccatag agacaacccc tcgctagacg     3840

tgaactcaga actgtcggag gaaagacaac acaaccaacg cgaaaccaat tcctcatcct     3900

cagatgctca aagttgtttt ttttgtttgt ttgtttatta gatgaattat cctatttcag     3960

tacttcagca agagagaacc taactgtatc ttgaggtggt agtaaaacac agagggccag     4020

taacgggtcg taatgactta ttgtggataa caaagatatc ttttctttag agaactgaaa     4080

agagagcaga gaatataaca tgaaatgata gatttgacct cctccctgtt attttcaagt     4140

agctgggatt ttaaactaga tgacctcatt aaccgatgct ttaccaaaca gcaaaccaag     4200

agattgctaa ttgctgttga aagcaaaaat gctaatatta aaagtcacaa tgttctttat     4260

atacaataat gg                                                         4272


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  ACT_SITE
<222>  (7)..(7)
<223>  This site may or may not be acetylated.

<400>  10

Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  ACT_SITE
<222>  (4)..(4)
<223>  This site may or may not be acetylated.

<400>  11

Leu Ala Gly Lys Leu Arg Ser Gly Asp Arg Ser 
1               5                   10      


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide probe

<400>  12
gagtggtgtg gtagtgcggt cgggg                                             25


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide probe

<400>  13
gagtggtgtg gtagtgctag cgggg                                             25


