                         SEQUENCE LISTING

<110>  Case Western Reserve University
 
<120>  NON-STANDARD INSULIN ANALOGUES

<130>  200512.00164

<150>  61/507,324
<151>  2011-07-13

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  86
<212>  PRT
<213>  Homo sapien

<400>  1

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is His or Asp

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Asp, Pro, Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lys or Pro

<400>  4

Phe Val Asn Gln His Leu Cys Gly Ser Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is His or Asp

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Asp, Pro, ornithine, diaminobutyric acid, 
       diaminoproprionic acid, norleucine, aminobutric acid, or 
       aminoproprionic acid

<400>  5

Phe Val Asn Gln His Leu Cys Gly Ser Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Cyclohexanylalanine

<400>  6

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  7
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Cyclohexanylalanine

<400>  7

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  8
<211>  86
<212>  PRT
<213>  homosapien


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is His or Phe

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Pro, Lys or Asp

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lys or Pro

<220>
<221>  MISC_FEATURE
<222>  (31)..(65)
<223>  Xaa is 0-35 of any amino acid or a break in the amino acid chain

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is His or Glu

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  Xaa is His or Thr

<400>  8

Xaa Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Xaa Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Gly Ile Val Xaa Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  9
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Cyclohexanylalanine

<400>  9

Phe Val Lys Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Glu Thr 
            20                  25                  30  


<210>  10
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is His or Asp

<400>  10

Phe Val Asn Gln His Leu Cys Gly Ser Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg 
            20          


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Phe Phe Tyr Thr Pro Lys Thr 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Phe or Cyclohexanylalanine

<400>  12

Gly Xaa Phe Tyr Thr Pro Lys Thr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Phe or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ornithine

<400>  13

Gly Xaa Phe Tyr Thr Pro Xaa Thr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Phe or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Norleucine

<400>  14

Gly Xaa Phe Tyr Thr Pro Xaa Thr 
1               5               


<210>  15
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  15
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg       60

gaacgaggct agttctacac acccaagacc                                        90


<210>  16
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  16
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt       60

gaaagaggtt agttttacac tccaaagact                                        90


<210>  17
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  17
tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg       60

gaacgaggct agttctacac acccaagacc cgccgggagg cagaggacct gcaggtgggg      120

caggtggagc tgggcggcgg ccctggtgca ggcagcctgc agcccttggc cctggagggg      180

tccctgcaga agcgtggcat tgtggaacaa tgctgtacca gcatctgctc cctctaccag      240

ctggagaact actgcaacta g                                                261


<210>  18
<211>  261
<212>  DNA
<213>  homosapien

<400>  18
tttgttaacc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt       60

gaaagaggtt agttttacac tccaaagact agaagagaag ctgaagattt gcaagttggt      120

caagttgaat tgggtggtgg tccaggtgct ggttctttgc aaccattggc tttggaaggt      180

tctttgcaaa agagaggtat tgttgaacaa tgttgtactt ctatttgttc tttgtaccaa      240

ttggaaaact actgtaacta a                                                261


<210>  19
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Ile Val Glu Gln Cys Cys Glu Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  20
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  20

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  21
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Cyclohexanylalanine

<400>  21

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  22
<211>  30
<212>  PRT
<213>  Homo sapien


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Cyclohexanylalanine

<400>  22

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Xaa Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  23

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


