                         SEQUENCE LISTING

<110>  University of Rochester
       Tieu, Kim
       Rappold, Phillip
 
<120>  TREATING NEUROLOGICAL DISEASE OR INJURY WITH A DYNAMIN-RELATED 
       PROTEIN 1 (DRP1) ENCODING NUCLEIC ACID

<130>  10028-069WO1

<140>  US 61/506,873
<141>  2011-07-12

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  4612
<212>  DNA
<213>  Homo sapiens

<400>  1
gcatggcctg ccgggagggg gcaggtagcc ggcgggcccg gtccaatggg tgccggcttc       60

cgaggagagg gcggaggaga ggaggaagga ggcgaactgt gggccccggc cccattcatt      120

gccgtggccg gcgggcactg gggccccgtg ttttcagagt catggaggcg ctaattcctg      180

tcataaacaa gctccaggac gtcttcaaca cggtgggcgc cgacatcatc cagctgcctc      240

aaatcgtcgt agtgggaacg cagagcagcg gaaagagctc agtgctagaa agcctggtgg      300

ggagggacct gcttcccaga ggtactggaa ttgtcacccg gagacctctc attctgcaac      360

tggtccatgt ttcacaagaa gataaacgga aaacaacagg agaagaaaat ggggtggaag      420

cagaagaatg gggtaaattt cttcacacca aaaataagct ttacacggat tttgatgaaa      480

ttcgacaaga aattgaaaat gaaacagaaa gaatttcagg aaataataag ggagtaagcc      540

ctgaaccaat tcatcttaag attttttcac ccaacgttgt caatttgaca cttgtggatt      600

tgccaggaat gaccaaggtg cctgtaggtg atcaacctaa ggatattgag cttcaaatca      660

gagagctcat tcttcggttc atcagtaatc ctaattccat tatcctcgct gtcactgctg      720

ctaatacaga tatggcaaca tcagaggcac ttaaaatttc aagagaggta gatccagatg      780

gtcgcagaac cctagctgta atcactaaac ttgatctcat ggatgcgggt actgatgcca      840

tggatgtatt gatgggaagg gttattccag tcaaacttgg aataattgga gtagttaaca      900

ggagccagct agatattaac aacaagaaga gtgtaactga ttcaatccgt gatgagtatg      960

cttttcttca aaagaaatat ccatctctgg ccaatagaaa tggaacaaag tatcttgcta     1020

ggactctaaa caggttactg atgcatcaca tcagagattg tttaccagag ttgaaaacaa     1080

gaataaatgt tctagctgct cagtatcagt ctcttctaaa tagctacggt gaacccgtgg     1140

atgataaaag tgctacttta ctccaactta ttaccaaatt tgccacagaa tattgtaaca     1200

ctattgaagg aactgcaaaa tatattgaaa cttcggagct atgcggtggt gctagaattt     1260

gttatatttt ccatgagact tttgggcgaa ccttagaatc tgttgatcca cttggtggcc     1320

ttaacactat tgacattttg actgccatta gaaatgctac tggtcctcgt cctgctttat     1380

ttgtgcctga ggtttcattt gagttactgg tgaagcggca aatcaaacgt ctagaagagc     1440

ccagcctccg ctgtgtggaa ctggttcatg aggaaatgca aaggatcatt cagcactgta     1500

gcaattacag tacacaggaa ttgttacgat ttcctaaact tcatgatgcc atagttgaag     1560

tggtgacttg tcttcttcgt aaaaggttgc ctgttacaaa tgaaatggtc cataacttag     1620

tggcaattga actggcttat atcaacacaa aacatccaga ctttgctgat gcttgtgggc     1680

taatgaacaa taatatagag gaacaaagga gaaacaggct agccagagaa ttaccttcag     1740

ctgtatcacg agacaagtct tctaaagttc caagtgcttt ggcacctgcc tcccaggagc     1800

cctcccccgc tgcttctgct gaggctgatg gcaagttaat tcaggacagc agaagagaaa     1860

ctaaaaatgt tgcatctgga ggtggtgggg ttggagatgg tgttcaagaa ccaaccacag     1920

gcaactggag aggaatgctg aaaacttcaa aagctgaaga gttattagca gaagaaaaat     1980

caaaacccat tccaattatg ccagccagtc cacaaaaagg tcatgccgtg aacctgctag     2040

atgtgccagt tcctgttgca cgaaaactat ctgctcggga acagcgagat tgtgaggtta     2100

ttgaacgact cattaaatca tattttctca ttgtcagaaa gaatattcaa gacagtgtgc     2160

caaaggcagt aatgcatttt ttggttaatc atgtgaaaga cactcttcag agtgagctag     2220

taggccagct gtataaatca tccttattgg atgatcttct gacagaatct gaggacatgg     2280

cacagcgcag gaaagaagca gctgatatgc taaaggcatt acaaggagcc agtcaaatta     2340

ttgctgaaat ccgggagact catctttggt gaagagaact atgtaatact gagactttgt     2400

tgactcaaaa cttgctagtt actgcctacc tgagtagaat cttatttatg aactcctgtg     2460

tattgcaatg gtatgaatct gctcatgtgg agactggcta taaactgaaa agtgtattcc     2520

aaattgcaga acacatcaca catttaatcc aaataataaa tggctgtttc taaagtttcc     2580

cagtatatat aaaatacatc aagtctgtct tgtgacagtt tcatctgaac ttaacttaaa     2640

aacaactgtt aatgttctag ttgtgcaaag cagtttgcct gtggataaga tgacctgtgt     2700

aataatcttt gttagtagtc ttaaagctgc tgccatagtc ctccaagaag aaagcaccaa     2760

gacaacattt catatgacta taatgcatgt actatataag ctgatctggc tttgaaagat     2820

gtgagttggc aagttcctca catagagtca ttgtattcca cctgtccttc aatttagttt     2880

tttctgagct tctttgcagc ctttgatgtg tttttaagaa agctgaatgc acaagaggat     2940

ctgtgacact gacatggctg tggtgtgcat actgtgtagt tacatagccc ttccaattct     3000

gggtccattt gcactagcaa attaaaatat gctttgattc atacttaaac ctgaaagcag     3060

gaatgcctac attaattcct acattaaaaa cagccatcta cccttgatta tctagaaaga     3120

cttggtaatg atggtcagtt ccttttagat ttcagaaaat caaatgatga cctaaatttc     3180

ccttaatttg caaatacagt agtaattaag gtacatctct aaagtggagc acttacacca     3240

ggctctaaga ttcactttga ggtggaactt aaaaccagtg tactgtatgt atgcattggt     3300

aatagctact tttgcttcat agcttcatac caacaaaata tatttattag aatagtatga     3360

aagtactgga ggagctgaaa gaaaaacacc caaggctggg cgtggtggca cacgcctgta     3420

atcccagcac tttgggaggc cgaggcaggt ggatcacctg aggttgggag ttggagacca     3480

gcttgaccaa catggagaaa ccccgtctct actaaaaata caaaattggc cgggcgtggt     3540

ggcgcatgcc tgtaatccca gctactcggg agggtgaggc aggagaattg cttgaccctg     3600

ggaggtggag gttgtggtga gctaagatcg tgccattgca ctccagcctt ggcaacaaga     3660

gcgaaactcc gtctcaaaaa aaaaaaataa aacaacaccc agatagatac acatactcct     3720

tcagacttac agacctaagc tgcatttatg gggtagtgat gaggtttaga acatatacat     3780

attttgttaa aattccccag atgattcttg gtatgaacga ctatattata aattttaaga     3840

tgtacttaga aatccttaag acatctagcc ccgtctctaa tagacaacac atttatattg     3900

cagatattac ttttttttca gtttatgacc aggtatttat gaaggactat tggcagggaa     3960

aatatgaata tgttaacttt agcttatggc atcaatttac taaggaacaa caggctcacc     4020

aactgatgtc aaacataaaa acccccacat cagtctgata cgatatggta ctactttgaa     4080

tctgttacta gtaccatctt gacagaggat acatgctccc aaaacgtttg ttaccacact     4140

taaaaatcac tgccatcatt aagcatcagt ttcaaaatta tagccattca tgatttactt     4200

tttccagatg actatcatta ttctagtcct ttgaatttgt aaggggaaaa aaaacaaaaa     4260

caaaaactta cgatgcactt ttctccagca catcagattt caaattgaaa attaaagaca     4320

tgctatggta atgcacttgc tagtactaca cactttgtac aacaaaaaac agaggcaaga     4380

aacaacggaa agagaaaagc cttcctttgt tggcccttaa actgagtcaa gatctgaaat     4440

gtagagatga tctctgacga tacctgtatg ttcttattgt gtaaataaaa ttgctggtat     4500

gaaatgacac taaagtttgt caaaaaatga attcttaact tttctcccag agaaagggag     4560

acaaaaggag ctttttaata cctaatctac tttggaacat aaccgtatag ag             4612


<210>  2
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                85                  90                  95      


Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
            100                 105                 110         


Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
        115                 120                 125             


Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
    130                 135                 140                 


Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
145                 150                 155                 160 


Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                165                 170                 175     


Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
            180                 185                 190         


Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
        195                 200                 205             


Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
    210                 215                 220                 


Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
225                 230                 235                 240 


Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                245                 250                 255     


Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
            260                 265                 270         


Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
        275                 280                 285             


Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
    290                 295                 300                 


Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
305                 310                 315                 320 


Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                325                 330                 335     


Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
            340                 345                 350         


Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
        355                 360                 365             


Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
    370                 375                 380                 


Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
385                 390                 395                 400 


Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                405                 410                 415     


Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
            420                 425                 430         


Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
        435                 440                 445             


Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
    450                 455                 460                 


Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
465                 470                 475                 480 


Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                485                 490                 495     


Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
            500                 505                 510         


Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
        515                 520                 525             


Ser Arg Asp Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser 
    530                 535                 540                 


Gln Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Leu Ile 
545                 550                 555                 560 


Gln Asp Ser Arg Arg Glu Thr Lys Asn Val Ala Ser Gly Gly Gly Gly 
                565                 570                 575     


Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met 
            580                 585                 590         


Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys 
        595                 600                 605             


Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn 
    610                 615                 620                 


Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu 
625                 630                 635                 640 


Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu 
                645                 650                 655     


Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro Lys Ala Val Met His 
            660                 665                 670         


Phe Leu Val Asn His Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly 
        675                 680                 685             


Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu 
    690                 695                 700                 


Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu 
705                 710                 715                 720 


Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp 
                725                 730                 735     


<210>  3
<211>  2515
<212>  DNA
<213>  rattus norvegicus

<400>  3
ggcgcgtggc ctgccgggag cgggctggga ggtggcggcc tagcccaatg ggtgcgtgct       60

cccgaggaga gggcggagga gaaaaggaag caagcgggct gcgggctgcg tccccattca      120

ttgcagtggt ctgctgggtt ggggtccagt gtttccggag tcatggaggc gctgatcccg      180

gtcatcaata agctgcaaga cgtcttcaac accgtgggcg ccgacatcat ccagctgcct      240

cagattgtcg tagtgggaac tcagagcagt ggaaagagct cagtgctgga aagcctagtg      300

gggagggacc ttcttcccag agggactggt gtggtcaccc ggagacctct tattctgcag      360

ctggtccacg tttcaccaga agataaaaga aaaacaacag gagaagaaaa tggagttgaa      420

gcagaagaat ggggtaaatt tcttcacacc aaaaacaagc tttacacaga ttttgatgaa      480

attcgacaag aaattgaaaa tgaaactgaa agaatttcag gaaataataa gggagtaagc      540

cctgagccaa tccatctcaa ggttttctcg cccaacgttg tcaacctgac gcttgtggat      600

ttaccaggaa tgaccaaagt acctgtaggt gatcagccca aggatattga gcttcaaatc      660

agagaactta ttcttcggtt catcagtaat cccaattcca ttatccttgc tgtcactgct      720

gcaaatacag atatggcaac gtcagaggca cttaagattt ccagagaggt agatccagat      780

gggcgcagaa ctctagctgt aatcaccaag cttgatctca tggatgcggg tactgatgcc      840

atggatgtat tgatgggaag ggttattcca gtcaagcttg gaataattgg agtagttaac      900

aggagccaac tggacattaa caataagaag agtgtaactg attcaatccg tgatgagtat      960

gcttttcttc aaaagaagta cccatctctg gccaacagaa atggaacaaa gtatcttgct     1020

aggactctga ataggttact tatgcatcat atcagagact gtttaccaga gctgaaaaca     1080

agaataaatg tcttagctgc tcagtatcag tctcttctaa atagctatgg tgagcccgtg     1140

gatgataaaa gtgctacttt actccagctc attaccaagt ttgccacaga gtattgtaac     1200

actattgaag gaacggcaaa gtacattgaa acttctgagc tatgtggtgg tgctaggatt     1260

tgttatattt tccatgagac ttttgggcga accttagaat ctgttgatcc actaggtggc     1320

cttaacacta ttgacatctt gaccgccatt agaaatgcta ctggcccccg tccagcttta     1380

tttgtgcctg aagtttcatt tgagttactg gtcaaacgtc agattaagcg tctagaggag     1440

cccagcctcc gctgtgtgga gctggtccac gaggaaatgc agaggatcat tcagcactgt     1500

agcaactaca gcacacagga actgttacgg ttccctaaac tccatgatgc catagttgaa     1560

gtagtgactt gtcttcttcg taaaaggttg cccgtgacaa atgaaatggt acataactta     1620

gtggcaattg agctagcata tatcaacaca aaacaccccg actttgctga tgcctgtggg     1680

ctaatgaaca ataacataga ggaacaaaga agaaacagac tagcaagaga actaccttcc     1740

gctgtatcgc gagacaagtt aattcaggac aacagaagag aaactaaaaa tgttgcatct     1800

gcaggtggtg gaattggaga tggtggtcga attggagatg gtggtcagga accgacaaca     1860

ggcaactgga gaggaatgct gaaaacttca aaagctgaag aattacttgc tgaagaaaaa     1920

tcaaaaccaa ttccaattat gccagcaagt ccacaaaaag gccatgctgt caatttgcta     1980

gatgtgccag ttccagttgc acgaaaactg tctgcccgag aacagcgaga ttgtgaggtt     2040

attgaaagac tcatcaaatc atattttcta attgtcagaa agaatattca agacagcgtc     2100

ccaaaggcag taatgcattt tttggttaat catgtgaaag atactcttca gagtgaatta     2160

gtagggcagc tgtataagtc atccttatta gatgaccttc tgactgaatc cgaggacatg     2220

gcacagcgaa gaaaagaagc ggctgacatg ctgaaggcat tacaaggagc cagtcaaatt     2280

attgctgaaa tccgagagac tcatctttgg tgaacagaac tgtttggtct tctacacttt     2340

gctgacttga acctactagc tactgcctac ctgagtagaa atttatttat ggacttttgt     2400

gtatcgcagt gtatgaattt gcttgtgtga agactggcta taagctgaaa agtatattat     2460

tcattacaag acaaatcaca tgtttaattc aaaaaaaaaa aaaaaaaaaa aaaaa          2515


<210>  4
<211>  716
<212>  PRT
<213>  rattus norvegicus

<400>  4

Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Val Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Pro Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                85                  90                  95      


Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
            100                 105                 110         


Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
        115                 120                 125             


Pro Ile His Leu Lys Val Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
    130                 135                 140                 


Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
145                 150                 155                 160 


Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                165                 170                 175     


Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
            180                 185                 190         


Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
        195                 200                 205             


Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
    210                 215                 220                 


Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
225                 230                 235                 240 


Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                245                 250                 255     


Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
            260                 265                 270         


Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
        275                 280                 285             


Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
    290                 295                 300                 


Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
305                 310                 315                 320 


Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                325                 330                 335     


Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
            340                 345                 350         


Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
        355                 360                 365             


Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
    370                 375                 380                 


Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
385                 390                 395                 400 


Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                405                 410                 415     


Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
            420                 425                 430         


Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
        435                 440                 445             


Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
    450                 455                 460                 


Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
465                 470                 475                 480 


Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                485                 490                 495     


Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
            500                 505                 510         


Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
        515                 520                 525             


Ser Arg Asp Lys Leu Ile Gln Asp Asn Arg Arg Glu Thr Lys Asn Val 
    530                 535                 540                 


Ala Ser Ala Gly Gly Gly Ile Gly Asp Gly Gly Arg Ile Gly Asp Gly 
545                 550                 555                 560 


Gly Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met Leu Lys Thr Ser 
                565                 570                 575     


Lys Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys Pro Ile Pro Ile 
            580                 585                 590         


Met Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn Leu Leu Asp Val 
        595                 600                 605             


Pro Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu Gln Arg Asp Cys 
    610                 615                 620                 


Glu Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu Ile Val Arg Lys 
625                 630                 635                 640 


Asn Ile Gln Asp Ser Val Pro Lys Ala Val Met His Phe Leu Val Asn 
                645                 650                 655     


His Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly Gln Leu Tyr Lys 
            660                 665                 670         


Ser Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu Asp Met Ala Gln 
        675                 680                 685             


Arg Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu Gln Gly Ala Ser 
    690                 695                 700                 


Gln Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp 
705                 710                 715     


<210>  5
<211>  4078
<212>  DNA
<213>  Mus musculus

<400>  5
gtcgtggcgc gtggcctgcc gggagcgggc tgggtgctgg cccggcccaa tgggtgcggg       60

ctcccgagga aagggcggag gagaagagga agcaagcggg ctgtgggtcg agtccccatt      120

cattgcagtg gcctgctggg ttgggggtcc agtgtttcgg gggtcatgga ggcgctgatc      180

ccggtcatca ataagctgca ggacgtcttc aacacagtgg gtgcggacat catccagctg      240

cctcagatcg tcgtagtggg aacgcagagc agtgggaaga gctcagtgct ggaaagccta      300

gtgggcaggg accttcttcc cagaggaact ggtgtggtca cccggagacc tctcattctg      360

cagctagtcc acgtttcacc agaagataaa agaaaaacaa caggagaaga aaatgaccct      420

gccacatgga aaaactcaag acacctttcc aaaggagttg aagcagaaga atggggtaaa      480

tttcttcaca ccaaaaacaa gctttacaca gattttgatg aaattcgaca agaaattgaa      540

aatgaaactg aaagaatttc aggaaataat aagggggtaa gccctgagcc aatccatctc      600

aaggttttct cgcccaacgt tgtcaacctg acacttgtgg atttaccggg aatgaccaaa      660

gtacctgtag gcgatcagcc caaggacatc gagcttcaga tcagagaact tattcttcgg      720

ttcatcagta atcccaattc cattatcctc gccgtcactg ctgcaaatac agatatggca      780

acatcagaag cactcaagat ttccagagag gtagatccag atgggcgcag aactctagct      840

gtaatcacta aacttgatct catggatgcg ggtactgatg ccatggatgt attgatggga      900

agggttattc cagtcaagct tggaataatt ggagtagtta acagaagcca actggatatt      960

aacaataaga agagtgtaac tgattcaatc cgtgatgagt atgcttttct tcaaaagaag     1020

tacccatctc tggccaacag aaatggaaca aagtatcttg ctaggaccct gaataggtta     1080

cttatgcatc atatcagaga ttgtttacca gagctgaaaa caagaataaa tgtcttagct     1140

gctcagtatc agtctcttct aaatagctat ggtgaaccgg tggatgataa aagtgctact     1200

ttactccagc ttattaccaa atttgccaca gagtattgta acacgattga aggaaccgca     1260

aagtacattg aaacttctga gctatgcggt ggtgctagga tttgttatat tttccatgag     1320

actttcgggc gaaccttaga atctgtggac ccactaggtg gccttaacac tattgacatc     1380

ctgactgcca tcagaaatgc tactggcccc cgtcctgctt tatttgtgcc tgaagtttca     1440

tttgagttac tggtcaaacg tcagattaag cgtctagaag agcccagcct acggtgtgtg     1500

gagctggtcc atgaggagat gcagaggatc attcagcatt gtagcaatta cagcacacag     1560

gaattgttac ggttccctaa acttcacgat gccatagttg aagtagtgac ctgtcttctt     1620

cgtaaaaggt tgcccgtgac aaatgaaatg gtgcataact tagtggcaat tgagctagcg     1680

tatatcaaca caaaacaccc cgactttgct gatgcctgtg ggctaatgaa caataatata     1740

gaggaacaaa gaagaaacag gctagcaaga gagctgcctt cagctggatc acgggacaag     1800

gtcccatctg caggtggtgg gattggagac ggtggtcagg aaccaacaac aggcaactgg     1860

agaggaatgc tgaaaacttc aaaagctgaa gaattacttg ctgaagaaaa atcaaaacca     1920

attccaatta tgccagcaag tccacagaaa ggccatgctg tcaatttgct agatgtgcca     1980

gttccagttg caagaaaact gtctgcccga gaacagcgag attgtgaggt tattgaaaga     2040

cttatcaaat catattttct aattgtcaga aagaatattc aagacagtgt cccaaaggca     2100

gtaatgcatt ttttggttaa tcatgtgaaa gatactcttc agagtgaact ggtagggcag     2160

ctgtataagt catccttatt agatgacctt ctgactgaat ccgaggacat ggcccaacga     2220

agaaaagaag cagcggatat gctgaaggca ttacaaggag ccagtcaaat tattgctgaa     2280

atccgagaga ctcatctttg gtgaacagaa ctgtttgata tccacacttt gctgacttga     2340

acctgctgct gcctacctga gtagaagttt atgaactttt gtgtattgca gtgtatgaat     2400

ttgctcgtgt gaagactggc tataagctga aaagtatatt attcgttaca aaacaaatca     2460

catgtttaat tcacattttt caagtttcct atgacgtata tcaagtctgt ccgtttcagt     2520

cgaacttaca agagcaattg atattctagt tgtacaaagc agtttgcctg tgcatatgac     2580

ccatgtaact ttcttagtct caaagctgca gctgtagtcc tcagaaagga agctccagga     2640

catttcatga ctataatgca tgcactattt atatagactg acctggcttt aaaagatgga     2700

gcctggcaag ttcctcacat aatcaatgta tccacctatc cttcattttt atagtcttaa     2760

aaaacaaaca aaactctttt gcagtttcaa gaaatatata agatcttaaa gactcatcaa     2820

gatgtaggaa cagactgtgt aattaatggc tcctgagtct acactgccct ggtgcattag     2880

aaattaaaaa tactttgatt ctaaaaaagc ctgaaaattt aatgacttcc tgcattaaaa     2940

acaactattg ggaactgtta gtaacaatgg ctagtcctat tagtctctaa atgatccaat     3000

gataacctaa atttctctta tttacaaata cagcaattgc aatccagata cacccttaaa     3060

atggggcact taaattgggc tccaagactc acagttaaat ggaacctaaa attccactct     3120

ttatccactg gtaatagcta ctttagttcc acgccaacag aatacattag actaatggta     3180

tgaaaacact agtggacctt tattaaagaa aaacatctgg acacacacat acatacacct     3240

aaaagcttat ggacttcatt cagggggtta gggtaatgtt tacaacctat tttgtgaaaa     3300

ctgcctgtac aaatcgtctt ttaaactaag cattgaaaag ttttctcacc tagctgggca     3360

gtggtggtgc aagcctttaa tcccagcact tgggaggcag acgtgggtgg aggatctctg     3420

agttcaaggc caccgtggtt ccagacaact agaactacag agaaaccttg tcttgaaaaa     3480

cccaaaaaat tgaaacctaa gtagaaatcc ttgatgtatc tagttgtctc tgaccaaatg     3540

atacattcgt tttataaata ctaaaattct tttcaggtta tggtcaggca tcttatgaaa     3600

tactattagc aaggaaaaca agaacatgtt atctttagtt tatgatgccc actgagcaat     3660

ctcaaaatca taaaagcagt ttgatacagt accggcttga cagtgagtac acactgccta     3720

aatgtgttag catactttaa aaaaataccc tcttatccaa ctattaggta tcagtgactt     3780

aattttttaa gaaagatgac caccactgta gcctttttga atttgtaagg acaaagaaat     3840

gcacctttat ccaacatttc aaataaattt taaatggaag atgtttagca ctacacactt     3900

tgtacaaagg aaaacaagca agaaacaggg aaaggggaag cttcctttgt gtgcttttac     3960

actgatgtgt tctgaaacat ggagataatt tctggcatat ttataagacg actgtatgtt     4020

ctatgtaaat aaaaatgctg gtgtgcaatt gccagtaaaa aaaaaaaaaa aaaaaaaa       4078


<210>  6
<211>  712
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Val Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Pro Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Asp Pro Ala Thr Trp Lys Asn Ser Arg His Leu Ser Lys 
                85                  90                  95      


Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr Lys Asn Lys 
            100                 105                 110         


Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu Asn Glu Thr 
        115                 120                 125             


Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu Pro Ile His 
    130                 135                 140                 


Leu Lys Val Phe Ser Pro Asn Val Val Asn Leu Thr Leu Val Asp Leu 
145                 150                 155                 160 


Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys Asp Ile Glu 
                165                 170                 175     


Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn Pro Asn Ser 
            180                 185                 190         


Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala Thr Ser Glu 
        195                 200                 205             


Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg Arg Thr Leu 
    210                 215                 220                 


Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr Asp Ala Met 
225                 230                 235                 240 


Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly Ile Ile Gly 
                245                 250                 255     


Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys Ser Val Thr 
            260                 265                 270         


Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys Tyr Pro Ser 
        275                 280                 285             


Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr Leu Asn Arg 
    290                 295                 300                 


Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu Lys Thr Arg 
305                 310                 315                 320 


Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn Ser Tyr Gly 
                325                 330                 335     


Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu Ile Thr Lys 
            340                 345                 350         


Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala Lys Tyr Ile 
        355                 360                 365             


Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr Ile Phe His 
    370                 375                 380                 


Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu Gly Gly Leu 
385                 390                 395                 400 


Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr Gly Pro Arg 
                405                 410                 415     


Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu Val Lys Arg 
            420                 425                 430         


Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val Glu Leu Val 
        435                 440                 445             


His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn Tyr Ser Thr 
    450                 455                 460                 


Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile Val Glu Val 
465                 470                 475                 480 


Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn Glu Met Val 
                485                 490                 495     


His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr Lys His Pro 
            500                 505                 510         


Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile Glu Glu Gln 
        515                 520                 525             


Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Gly Ser Arg Asp 
    530                 535                 540                 


Lys Val Pro Ser Ala Gly Gly Gly Ile Gly Asp Gly Gly Gln Glu Pro 
545                 550                 555                 560 


Thr Thr Gly Asn Trp Arg Gly Met Leu Lys Thr Ser Lys Ala Glu Glu 
                565                 570                 575     


Leu Leu Ala Glu Glu Lys Ser Lys Pro Ile Pro Ile Met Pro Ala Ser 
            580                 585                 590         


Pro Gln Lys Gly His Ala Val Asn Leu Leu Asp Val Pro Val Pro Val 
        595                 600                 605             


Ala Arg Lys Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu Val Ile Glu 
    610                 615                 620                 


Arg Leu Ile Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn Ile Gln Asp 
625                 630                 635                 640 


Ser Val Pro Lys Ala Val Met His Phe Leu Val Asn His Val Lys Asp 
                645                 650                 655     


Thr Leu Gln Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser Ser Leu Leu 
            660                 665                 670         


Asp Asp Leu Leu Thr Glu Ser Glu Asp Met Ala Gln Arg Arg Lys Glu 
        675                 680                 685             


Ala Ala Asp Met Leu Lys Ala Leu Gln Gly Ala Ser Gln Ile Ile Ala 
    690                 695                 700                 


Glu Ile Arg Glu Thr His Leu Trp 
705                 710         


