                         SEQUENCE LISTING

<110>  Protaffin Biotechnologie AG
 
<120>  Novel SDF-1 based glycosaminoglycan antagonist and methods for 
       using same

<130>  PA011P

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  68
<212>  PRT
<213>  human

<400>  1

Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys 
65              


<210>  2
<211>  61
<212>  PRT
<213>  artificial

<220>
<223>  mutant SDF1

<400>  2

Met Cys Pro Cys Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val 
1               5                   10                  15      


Lys His Leu Lys Ile Lys Asn Thr Pro Asn Cys Ala Leu Gln Ile Lys 
            20                  25                  30          


Ala Arg Leu Lys Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu 
        35                  40                  45              


Lys Trp Ile Gln Lys Tyr Leu Glu Lys Ala Leu Asn Lys 
    50                  55                  60      


<210>  3
<211>  61
<212>  PRT
<213>  artificial

<220>
<223>  mutant SDF1

<400>  3

Met Cys Pro Cys Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val 
1               5                   10                  15      


Lys His Leu Lys Ile Lys Asn Thr Pro Asn Cys Ala Leu Gln Ile Lys 
            20                  25                  30          


Ala Arg Leu Lys Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu 
        35                  40                  45              


Lys Trp Ile Gln Lys Tyr Leu Glu Lys Ala Leu Lys Lys 
    50                  55                  60      


<210>  4
<211>  61
<212>  PRT
<213>  artificial

<220>
<223>  mutant SDF1

<400>  4

Met Cys Pro Cys Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val 
1               5                   10                  15      


Lys His Leu Lys Ile Lys Asn Thr Pro Asn Cys Ala Leu Gln Ile Lys 
            20                  25                  30          


Ala Arg Leu Lys Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu 
        35                  40                  45              


Lys Trp Ile Gln Lys Tyr Leu Glu Lys Ala Leu Lys Arg 
    50                  55                  60      


<210>  5
<211>  61
<212>  PRT
<213>  artificial

<220>
<223>  mutant SDF1

<400>  5

Met Cys Pro Cys Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val 
1               5                   10                  15      


Lys His Leu Lys Ile Lys Asn Thr Pro Asn Cys Ala Leu Gln Ile Lys 
            20                  25                  30          


Ala Arg Leu Lys Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu 
        35                  40                  45              


Lys Trp Ile Gln Lys Tyr Leu Glu Lys Ala Leu Asn Arg 
    50                  55                  60      


<210>  6
<211>  99
<212>  PRT
<213>  artificial

<220>
<223>  mutant SDF1


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Arg or Lys

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Pro or Gly

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is Leu, Arg, His or Lys

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa is Val, Arg, His or Lys

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa is Val or Ala

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa is Glu, Arg, His or Lys

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa is Asn, Arg, His or Lys

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa is Arg, His or Lys

<400>  6

Met Xaa Xaa Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu 
1               5                   10                  15      


Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Xaa Asn Thr 
            20                  25                  30          


Pro Asn Cys Ala Leu Gln Ile Xaa Ala Arg Leu Lys Asn Asn Asn Arg 
        35                  40                  45              


Gln Xaa Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Xaa Tyr Leu Glu 
    50                  55                  60                  


Lys Ala Leu Xaa Xaa Gly Arg Arg Glu Glu Lys Val Gly Lys Lys Glu 
65                  70                  75                  80  


Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys Ala Ala Gln Lys 
                85                  90                  95      


Arg Lys Asn 
            


<210>  7
<211>  183
<212>  DNA
<213>  artificial

<220>
<223>  mutant SDF1

<400>  7
atgtgcccat gccgcttctt cgaatcccac gtcgctcgcg ctaacgttaa gcatctgaag     60

atcaaaaaca ccccgaattg tgcgctgcag atcaaagcgc gtctgaagaa caacaatcgt    120

caggtgtgta ttgacccgaa gctgaaatgg atccaaaagt atctggagaa agcattgaac    180

aag                                                                  183


<210>  8
<211>  183
<212>  DNA
<213>  artificial

<220>
<223>  mutant SDF1

<400>  8
atgtgcccat gccgcttctt cgaatcccac gtcgctcgcg ctaacgttaa gcatctgaag     60

atcaaaaaca ccccgaattg tgcgctgcag atcaaagcgc gtctgaagaa caacaatcgt    120

caggtgtgta ttgacccgaa gctgaaatgg atccagaagt acctggagaa agcattgaaa    180

aag                                                                  183


<210>  9
<211>  183
<212>  DNA
<213>  artificial

<220>
<223>  mutant SDF1

<400>  9
atgtgcccat gccgcttctt cgaatcccac gtcgctcgcg ctaacgttaa gcatctgaag     60

atcaaaaaca ccccgaattg tgcgctgcag atcaaagcgc gtctgaagaa caataaccgt    120

caggtgtgta ttgacccgaa gctgaaatgg atccaaaagt atctggagaa agcattgaaa    180

cgc                                                                  183


<210>  10
<211>  183
<212>  DNA
<213>  artificial

<220>
<223>  mutant SDF1

<400>  10
atgtgcccat gccgcttctt cgaatcccac gtcgctcgcg ctaacgttaa gcatctgaaa     60

atcaaaaaca ccccgaattg tgcgctgcag atcaaagcac gtctgaaaaa caataatcgt    120

caagtgtgta ttgacccgaa gctgaagtgg attcagaagt acttggagaa agcgctgaac    180

cgt                                                                  183


<210>  11
<211>  4131
<212>  DNA
<213>  artificial

<220>
<223>  pjExpress Vector with SDF1 insert

<400>  11
ctcatgacca aaatccctta acgtgagtta cgcgcgcgtc gttccactga gcgtcagacc     60

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct    120

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa    180

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag    240

tgtagccgta gttagcccac cacttcaaga actctgtagc accgcctaca tacctcgctc    300

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg    360

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca    420

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat    480

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg    540

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc    600

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc    660

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc    720

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg    780

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga    840

gcgaggaagc ggaaggcgag agtagggaac tgccaggcat caaactaagc agaaggcccc    900

tgacggatgg cctttttgcg tttctacaaa ctctttctgt gttgtaaaac gacggccagt    960

cttaagctcg ggccccctgg gcggttctga taacgagtaa tcgttaatcc gcaaataacg   1020

taaaaacccg cttcggcggg tttttttatg gggggagttt agggaaagag catttgtcag   1080

aatatttaag ggcgcctgtc actttgcttg atatatgaga attatttaac cttataaatg   1140

agaaaaaagc aacgcacttt aaataagata cgttgctttt tcgattgatg aacacctata   1200

attaaactat tcatctatta tttatgattt tttgtatata caatatttct agtttgttaa   1260

agagaattaa gaaaataaat ctcgaaaata ataaagggaa aatcagtttt tgatatcaaa   1320

attatacatg tcaacgataa tacaaaatat aatacaaact ataagatgtt atcagtattt   1380

attatgcatt tagaataaat tttgtgtcgc ccttccgcga aattaatacg actcactata   1440

ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa cttttaggag   1500

gtaaaacata tgtgcccatg ccgcttcttc gaatcccacg tcgctcgcgc taacgttaag   1560

catctgaaga tcaaaaacac cccgaattgt gcgctgcaga tcaaagcgcg tctgaagaac   1620

aacaatcgtc aggtgtgtat tgacccgaag ctgaaatgga tccaaaagta tctggagaaa   1680

gcattgaaca agtaataact cgagccccct agcataaccc cttggggcct ctaaacgggt   1740

cttgaggggt tttttgcccc tgagacgcgt caatcgagtt cgtacctaag ggcgacaccc   1800

cctaattagc ccgggcgaaa ggcccagtct ttcgactgag cctttcgttt tatttgatgc   1860

ctggcagttc cctactctcg catggggagt ccccacacta ccatcggcgc tacggcgttt   1920

cacttctgag ttcggcatgg ggtcaggtgg gaccaccgcg ctactgccgc caggcaaaca   1980

aggggtgtta tgagccatat tcaggtataa atgggctcgc gataatgttc agaattggtt   2040

aattggttgt aacactgacc cctatttgtt tatttttcta aatacattca aatatgtatc   2100

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagaatatga   2160

gccatattca acgggaaacg tcgaggccgc gattaaattc caacatggat gctgatttat   2220

atgggtataa atgggctcgc gataatgtcg ggcaatcagg tgcgacaatc tatcgcttgt   2280

atgggaagcc cgatgcgcca gagttgtttc tgaaacatgg caaaggtagc gttgccaatg   2340

atgttacaga tgagatggtc agactaaact ggctgacgga atttatgcca cttccgacca   2400

tcaagcattt tatccgtact cctgatgatg catggttact caccactgcg atccccggaa   2460

aaacagcgtt ccaggtatta gaagaatatc ctgattcagg tgaaaatatt gttgatgcgc   2520

tggcagtgtt cctgcgccgg ttgcactcga ttcctgtttg taattgtcct tttaacagcg   2580

atcgcgtatt tcgcctcgct caggcgcaat cacgaatgaa taacggtttg gttgatgcga   2640

gtgattttga tgacgagcgt aatggctggc ctgttgaaca agtctggaaa gaaatgcata   2700

aacttttgcc attctcaccg gattcagtcg tcactcatgg tgatttctca cttgataacc   2760

ttatttttga cgaggggaaa ttaataggtt gtattgatgt tggacgagtc ggaatcgcag   2820

accgatacca ggatcttgcc atcctatgga actgcctcgg tgagttttct ccttcattac   2880

agaaacggct ttttcaaaaa tatggtattg ataatcctga tatgaataaa ttgcagtttc   2940

atttgatgct cgatgagttt ttctaagcgg cgcgccatcg aatggcgcaa aacctttcgc   3000

ggtatggcat gatagcgccc ggaagagagt caattcaggg tggtgaatat gaaaccagta   3060

acgttatacg atgtcgcaga gtatgccggt gtctcttatc agaccgtttc ccgcgtggtg   3120

aaccaggcca gccacgtttc tgcgaaaacg cgggaaaaag tggaagcggc gatggcggag   3180

ctgaattaca ttcccaaccg cgtggcacaa caactggcgg gcaaacagtc gttgctgatt   3240

ggcgttgcca cctccagtct ggccctgcac gcgccgtcgc aaattgtcgc ggcgattaaa   3300

tctcgcgccg atcaactggg tgccagcgtg gtggtgtcga tggtagaacg aagcggcgtc   3360

gaagcctgta aagcggcggt gcacaatctt ctcgcgcaac gcgtcagtgg gctgatcatt   3420

aactatccgc tggatgacca ggatgccatt gctgtggaag ctgcctgcac taatgttccg   3480

gcgttatttc ttgatgtctc tgaccagaca cccatcaaca gtattatttt ctcccatgag   3540

gacggtacgc gactgggcgt ggagcatctg gtcgcattgg gtcaccagca aatcgcgctg   3600

ttagcgggcc cattaagttc tgtctcggcg cgtctgcgtc tggctggctg gcataaatat   3660

ctcactcgca atcaaattca gccgatagcg gaacgggaag gcgactggag tgccatgtcc   3720

ggttttcaac aaaccatgca aatgctgaat gagggcatcg ttcccactgc gatgctggtt   3780

gccaacgatc agatggcgct gggcgcaatg cgcgccatta ccgagtccgg gctgcgcgtt   3840

ggtgcggata tctcggtagt gggatacgac gataccgaag atagctcatg ttatatcccg   3900

ccgttaacca ccatcaaaca ggattttcgc ctgctggggc aaaccagcgt ggaccgcttg   3960

ctgcaactct ctcagggcca ggcggtgaag ggcaatcagc tgttgccagt ctcactggtg   4020

aaaagaaaaa ccaccctggc gcccaatacg caaaccgcct ctccccgcgc gttggccgat   4080

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg a            4131


<210>  12
<211>  4131
<212>  DNA
<213>  artificial

<220>
<223>  pJExpress vector with SDF1 insert

<400>  12
ctcatgacca aaatccctta acgtgagtta cgcgcgcgtc gttccactga gcgtcagacc     60

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct    120

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa    180

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag    240

tgtagccgta gttagcccac cacttcaaga actctgtagc accgcctaca tacctcgctc    300

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg    360

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca    420

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat    480

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg    540

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc    600

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc    660

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc    720

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg    780

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga    840

gcgaggaagc ggaaggcgag agtagggaac tgccaggcat caaactaagc agaaggcccc    900

tgacggatgg cctttttgcg tttctacaaa ctctttctgt gttgtaaaac gacggccagt    960

cttaagctcg ggccccctgg gcggttctga taacgagtaa tcgttaatcc gcaaataacg   1020

taaaaacccg cttcggcggg tttttttatg gggggagttt agggaaagag catttgtcag   1080

aatatttaag ggcgcctgtc actttgcttg atatatgaga attatttaac cttataaatg   1140

agaaaaaagc aacgcacttt aaataagata cgttgctttt tcgattgatg aacacctata   1200

attaaactat tcatctatta tttatgattt tttgtatata caatatttct agtttgttaa   1260

agagaattaa gaaaataaat ctcgaaaata ataaagggaa aatcagtttt tgatatcaaa   1320

attatacatg tcaacgataa tacaaaatat aatacaaact ataagatgtt atcagtattt   1380

attatgcatt tagaataaat tttgtgtcgc ccttccgcga aattaatacg actcactata   1440

ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa cttttaggag   1500

gtaaaacata tgtgcccatg ccgcttcttc gaatcccacg tcgctcgcgc taacgttaag   1560

catctgaaga tcaaaaacac cccgaattgt gcgctgcaga tcaaagcgcg tctgaagaac   1620

aacaatcgtc aggtgtgtat tgacccgaag ctgaaatgga tccagaagta cctggagaaa   1680

gcattgaaaa agtaataact cgagccccct agcataaccc cttggggcct ctaaacgggt   1740

cttgaggggt tttttgcccc tgagacgcgt caatcgagtt cgtacctaag ggcgacaccc   1800

cctaattagc ccgggcgaaa ggcccagtct ttcgactgag cctttcgttt tatttgatgc   1860

ctggcagttc cctactctcg catggggagt ccccacacta ccatcggcgc tacggcgttt   1920

cacttctgag ttcggcatgg ggtcaggtgg gaccaccgcg ctactgccgc caggcaaaca   1980

aggggtgtta tgagccatat tcaggtataa atgggctcgc gataatgttc agaattggtt   2040

aattggttgt aacactgacc cctatttgtt tatttttcta aatacattca aatatgtatc   2100

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagaatatga   2160

gccatattca acgggaaacg tcgaggccgc gattaaattc caacatggat gctgatttat   2220

atgggtataa atgggctcgc gataatgtcg ggcaatcagg tgcgacaatc tatcgcttgt   2280

atgggaagcc cgatgcgcca gagttgtttc tgaaacatgg caaaggtagc gttgccaatg   2340

atgttacaga tgagatggtc agactaaact ggctgacgga atttatgcca cttccgacca   2400

tcaagcattt tatccgtact cctgatgatg catggttact caccactgcg atccccggaa   2460

aaacagcgtt ccaggtatta gaagaatatc ctgattcagg tgaaaatatt gttgatgcgc   2520

tggcagtgtt cctgcgccgg ttgcactcga ttcctgtttg taattgtcct tttaacagcg   2580

atcgcgtatt tcgcctcgct caggcgcaat cacgaatgaa taacggtttg gttgatgcga   2640

gtgattttga tgacgagcgt aatggctggc ctgttgaaca agtctggaaa gaaatgcata   2700

aacttttgcc attctcaccg gattcagtcg tcactcatgg tgatttctca cttgataacc   2760

ttatttttga cgaggggaaa ttaataggtt gtattgatgt tggacgagtc ggaatcgcag   2820

accgatacca ggatcttgcc atcctatgga actgcctcgg tgagttttct ccttcattac   2880

agaaacggct ttttcaaaaa tatggtattg ataatcctga tatgaataaa ttgcagtttc   2940

atttgatgct cgatgagttt ttctaagcgg cgcgccatcg aatggcgcaa aacctttcgc   3000

ggtatggcat gatagcgccc ggaagagagt caattcaggg tggtgaatat gaaaccagta   3060

acgttatacg atgtcgcaga gtatgccggt gtctcttatc agaccgtttc ccgcgtggtg   3120

aaccaggcca gccacgtttc tgcgaaaacg cgggaaaaag tggaagcggc gatggcggag   3180

ctgaattaca ttcccaaccg cgtggcacaa caactggcgg gcaaacagtc gttgctgatt   3240

ggcgttgcca cctccagtct ggccctgcac gcgccgtcgc aaattgtcgc ggcgattaaa   3300

tctcgcgccg atcaactggg tgccagcgtg gtggtgtcga tggtagaacg aagcggcgtc   3360

gaagcctgta aagcggcggt gcacaatctt ctcgcgcaac gcgtcagtgg gctgatcatt   3420

aactatccgc tggatgacca ggatgccatt gctgtggaag ctgcctgcac taatgttccg   3480

gcgttatttc ttgatgtctc tgaccagaca cccatcaaca gtattatttt ctcccatgag   3540

gacggtacgc gactgggcgt ggagcatctg gtcgcattgg gtcaccagca aatcgcgctg   3600

ttagcgggcc cattaagttc tgtctcggcg cgtctgcgtc tggctggctg gcataaatat   3660

ctcactcgca atcaaattca gccgatagcg gaacgggaag gcgactggag tgccatgtcc   3720

ggttttcaac aaaccatgca aatgctgaat gagggcatcg ttcccactgc gatgctggtt   3780

gccaacgatc agatggcgct gggcgcaatg cgcgccatta ccgagtccgg gctgcgcgtt   3840

ggtgcggata tctcggtagt gggatacgac gataccgaag atagctcatg ttatatcccg   3900

ccgttaacca ccatcaaaca ggattttcgc ctgctggggc aaaccagcgt ggaccgcttg   3960

ctgcaactct ctcagggcca ggcggtgaag ggcaatcagc tgttgccagt ctcactggtg   4020

aaaagaaaaa ccaccctggc gcccaatacg caaaccgcct ctccccgcgc gttggccgat   4080

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg a            4131


<210>  13
<211>  4131
<212>  DNA
<213>  artificial

<220>
<223>  pJExpress Vector with insert

<400>  13
ctcatgacca aaatccctta acgtgagtta cgcgcgcgtc gttccactga gcgtcagacc     60

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct    120

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa    180

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag    240

tgtagccgta gttagcccac cacttcaaga actctgtagc accgcctaca tacctcgctc    300

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg    360

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca    420

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat    480

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg    540

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc    600

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc    660

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc    720

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg    780

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga    840

gcgaggaagc ggaaggcgag agtagggaac tgccaggcat caaactaagc agaaggcccc    900

tgacggatgg cctttttgcg tttctacaaa ctctttctgt gttgtaaaac gacggccagt    960

cttaagctcg ggccccctgg gcggttctga taacgagtaa tcgttaatcc gcaaataacg   1020

taaaaacccg cttcggcggg tttttttatg gggggagttt agggaaagag catttgtcag   1080

aatatttaag ggcgcctgtc actttgcttg atatatgaga attatttaac cttataaatg   1140

agaaaaaagc aacgcacttt aaataagata cgttgctttt tcgattgatg aacacctata   1200

attaaactat tcatctatta tttatgattt tttgtatata caatatttct agtttgttaa   1260

agagaattaa gaaaataaat ctcgaaaata ataaagggaa aatcagtttt tgatatcaaa   1320

attatacatg tcaacgataa tacaaaatat aatacaaact ataagatgtt atcagtattt   1380

attatgcatt tagaataaat tttgtgtcgc ccttccgcga aattaatacg actcactata   1440

ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa cttttaggag   1500

gtaaaacata tgtgcccatg ccgcttcttc gaatcccacg tcgctcgcgc taacgttaag   1560

catctgaaga tcaaaaacac cccgaattgt gcgctgcaga tcaaagcgcg tctgaagaac   1620

aataaccgtc aggtgtgtat tgacccgaag ctgaaatgga tccaaaagta tctggagaaa   1680

gcattgaaac gctaataact cgagccccct agcataaccc cttggggcct ctaaacgggt   1740

cttgaggggt tttttgcccc tgagacgcgt caatcgagtt cgtacctaag ggcgacaccc   1800

cctaattagc ccgggcgaaa ggcccagtct ttcgactgag cctttcgttt tatttgatgc   1860

ctggcagttc cctactctcg catggggagt ccccacacta ccatcggcgc tacggcgttt   1920

cacttctgag ttcggcatgg ggtcaggtgg gaccaccgcg ctactgccgc caggcaaaca   1980

aggggtgtta tgagccatat tcaggtataa atgggctcgc gataatgttc agaattggtt   2040

aattggttgt aacactgacc cctatttgtt tatttttcta aatacattca aatatgtatc   2100

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagaatatga   2160

gccatattca acgggaaacg tcgaggccgc gattaaattc caacatggat gctgatttat   2220

atgggtataa atgggctcgc gataatgtcg ggcaatcagg tgcgacaatc tatcgcttgt   2280

atgggaagcc cgatgcgcca gagttgtttc tgaaacatgg caaaggtagc gttgccaatg   2340

atgttacaga tgagatggtc agactaaact ggctgacgga atttatgcca cttccgacca   2400

tcaagcattt tatccgtact cctgatgatg catggttact caccactgcg atccccggaa   2460

aaacagcgtt ccaggtatta gaagaatatc ctgattcagg tgaaaatatt gttgatgcgc   2520

tggcagtgtt cctgcgccgg ttgcactcga ttcctgtttg taattgtcct tttaacagcg   2580

atcgcgtatt tcgcctcgct caggcgcaat cacgaatgaa taacggtttg gttgatgcga   2640

gtgattttga tgacgagcgt aatggctggc ctgttgaaca agtctggaaa gaaatgcata   2700

aacttttgcc attctcaccg gattcagtcg tcactcatgg tgatttctca cttgataacc   2760

ttatttttga cgaggggaaa ttaataggtt gtattgatgt tggacgagtc ggaatcgcag   2820

accgatacca ggatcttgcc atcctatgga actgcctcgg tgagttttct ccttcattac   2880

agaaacggct ttttcaaaaa tatggtattg ataatcctga tatgaataaa ttgcagtttc   2940

atttgatgct cgatgagttt ttctaagcgg cgcgccatcg aatggcgcaa aacctttcgc   3000

ggtatggcat gatagcgccc ggaagagagt caattcaggg tggtgaatat gaaaccagta   3060

acgttatacg atgtcgcaga gtatgccggt gtctcttatc agaccgtttc ccgcgtggtg   3120

aaccaggcca gccacgtttc tgcgaaaacg cgggaaaaag tggaagcggc gatggcggag   3180

ctgaattaca ttcccaaccg cgtggcacaa caactggcgg gcaaacagtc gttgctgatt   3240

ggcgttgcca cctccagtct ggccctgcac gcgccgtcgc aaattgtcgc ggcgattaaa   3300

tctcgcgccg atcaactggg tgccagcgtg gtggtgtcga tggtagaacg aagcggcgtc   3360

gaagcctgta aagcggcggt gcacaatctt ctcgcgcaac gcgtcagtgg gctgatcatt   3420

aactatccgc tggatgacca ggatgccatt gctgtggaag ctgcctgcac taatgttccg   3480

gcgttatttc ttgatgtctc tgaccagaca cccatcaaca gtattatttt ctcccatgag   3540

gacggtacgc gactgggcgt ggagcatctg gtcgcattgg gtcaccagca aatcgcgctg   3600

ttagcgggcc cattaagttc tgtctcggcg cgtctgcgtc tggctggctg gcataaatat   3660

ctcactcgca atcaaattca gccgatagcg gaacgggaag gcgactggag tgccatgtcc   3720

ggttttcaac aaaccatgca aatgctgaat gagggcatcg ttcccactgc gatgctggtt   3780

gccaacgatc agatggcgct gggcgcaatg cgcgccatta ccgagtccgg gctgcgcgtt   3840

ggtgcggata tctcggtagt gggatacgac gataccgaag atagctcatg ttatatcccg   3900

ccgttaacca ccatcaaaca ggattttcgc ctgctggggc aaaccagcgt ggaccgcttg   3960

ctgcaactct ctcagggcca ggcggtgaag ggcaatcagc tgttgccagt ctcactggtg   4020

aaaagaaaaa ccaccctggc gcccaatacg caaaccgcct ctccccgcgc gttggccgat   4080

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg a            4131


<210>  14
<211>  3931
<212>  DNA
<213>  artificial

<220>
<223>  pJExpress vector with SDF1 insert

<400>  14
ctcatgacca aaatccctta acgtgagtta cgcgcgcgtc gttccactga gcgtcagacc     60

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct    120

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa    180

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag    240

tgtagccgta gttagcccac cacttcaaga actctgtagc accgcctaca tacctcgctc    300

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg    360

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca    420

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat    480

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg    540

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc    600

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc    660

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc    720

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg    780

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga    840

gcgaggaagc ggaaggcgag agtagggaac tgccaggcat caaactaagc agaaggcccc    900

tgacggatgg cctttttgcg tttctacaaa ctctttctgt gttgtaaaac gacggccagt    960

cttaagctcg ggccccctgg gcggttctga taacgagtaa tcgttaatcc gcaaataacg   1020

taaaaacccg cttcggcggg tttttttatg gggggagttt agggaaagag catttgtcag   1080

aatatttaag ggcgcctgtc actttgcttg atatatgaga attatttaac cttataaatg   1140

agaaaaaagc aacgcacttt aaataagata cgttgctttt tcgattgatg aacacctata   1200

attaaactat tcatctatta tttatgattt tttgtatata caatatttct agtttgttaa   1260

agagaattaa gaaaataaat ctcgaaaata ataaagggaa aatcagtttt tgatatcaaa   1320

attatacatg tcaacgataa tacaaaatat aatacaaact ataagatgtt atcagtattt   1380

attatgcatt tagaataaat tttgtgtcgc ccttccgcga aattaatacg actcactata   1440

ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa cttttaggag   1500

cgagccccct agcataaccc cttggggcct ctaaacgggt cttgaggggt tttttgcccc   1560

tgagacgcgt caatcgagtt cgtacctaag ggcgacaccc cctaattagc ccgggcgaaa   1620

ggcccagtct ttcgactgag cctttcgttt tatttgatgc ctggcagttc cctactctcg   1680

catggggagt ccccacacta ccatcggcgc tacggcgttt cacttctgag ttcggcatgg   1740

ggtcaggtgg gaccaccgcg ctactgccgc caggcaaaca aggggtgtta tgagccatat   1800

tcaggtataa atgggctcgc gataatgttc agaattggtt aattggttgt aacactgacc   1860

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc   1920

tgataaatgc ttcaataata ttgaaaaagg aagaatatga gccatattca acgggaaacg   1980

tcgaggccgc gattaaattc caacatggat gctgatttat atgggtataa atgggctcgc   2040

gataatgtcg ggcaatcagg tgcgacaatc tatcgcttgt atgggaagcc cgatgcgcca   2100

gagttgtttc tgaaacatgg caaaggtagc gttgccaatg atgttacaga tgagatggtc   2160

agactaaact ggctgacgga atttatgcca cttccgacca tcaagcattt tatccgtact   2220

cctgatgatg catggttact caccactgcg atccccggaa aaacagcgtt ccaggtatta   2280

gaagaatatc ctgattcagg tgaaaatatt gttgatgcgc tggcagtgtt cctgcgccgg   2340

ttgcactcga ttcctgtttg taattgtcct tttaacagcg atcgcgtatt tcgcctcgct   2400

caggcgcaat cacgaatgaa taacggtttg gttgatgcga gtgattttga tgacgagcgt   2460

aatggctggc ctgttgaaca agtctggaaa gaaatgcata aacttttgcc attctcaccg   2520

gattcagtcg tcactcatgg tgatttctca cttgataacc ttatttttga cgaggggaaa   2580

ttaataggtt gtattgatgt tggacgagtc ggaatcgcag accgatacca ggatcttgcc   2640

atcctatgga actgcctcgg tgagttttct ccttcattac agaaacggct ttttcaaaaa   2700

tatggtattg ataatcctga tatgaataaa ttgcagtttc atttgatgct cgatgagttt   2760

ttctaagcgg cgcgccatcg aatggcgcaa aacctttcgc ggtatggcat gatagcgccc   2820

ggaagagagt caattcaggg tggtgaatat gaaaccagta acgttatacg atgtcgcaga   2880

gtatgccggt gtctcttatc agaccgtttc ccgcgtggtg aaccaggcca gccacgtttc   2940

tgcgaaaacg cgggaaaaag tggaagcggc gatggcggag ctgaattaca ttcccaaccg   3000

cgtggcacaa caactggcgg gcaaacagtc gttgctgatt ggcgttgcca cctccagtct   3060

ggccctgcac gcgccgtcgc aaattgtcgc ggcgattaaa tctcgcgccg atcaactggg   3120

tgccagcgtg gtggtgtcga tggtagaacg aagcggcgtc gaagcctgta aagcggcggt   3180

gcacaatctt ctcgcgcaac gcgtcagtgg gctgatcatt aactatccgc tggatgacca   3240

ggatgccatt gctgtggaag ctgcctgcac taatgttccg gcgttatttc ttgatgtctc   3300

tgaccagaca cccatcaaca gtattatttt ctcccatgag gacggtacgc gactgggcgt   3360

ggagcatctg gtcgcattgg gtcaccagca aatcgcgctg ttagcgggcc cattaagttc   3420

tgtctcggcg cgtctgcgtc tggctggctg gcataaatat ctcactcgca atcaaattca   3480

gccgatagcg gaacgggaag gcgactggag tgccatgtcc ggttttcaac aaaccatgca   3540

aatgctgaat gagggcatcg ttcccactgc gatgctggtt gccaacgatc agatggcgct   3600

gggcgcaatg cgcgccatta ccgagtccgg gctgcgcgtt ggtgcggata tctcggtagt   3660

gggatacgac gataccgaag atagctcatg ttatatcccg ccgttaacca ccatcaaaca   3720

ggattttcgc ctgctggggc aaaccagcgt ggaccgcttg ctgcaactct ctcagggcca   3780

ggcggtgaag ggcaatcagc tgttgccagt ctcactggtg aaaagaaaaa ccaccctggc   3840

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg   3900

acaggtttcc cgactggaaa gcgggcagtg a                                  3931


<210>  15
<211>  99
<212>  PRT
<213>  artificial

<220>
<223>  mutant SDF-1


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Pro or Lys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arg, Lys or His

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is Arg , Lys or His

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa is Arg , Lys or His

<400>  15

Met Xaa Xaa Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu 
1               5                   10                  15      


Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Xaa Asn Thr 
            20                  25                  30          


Pro Asn Cys Ala Leu Gln Ile Xaa Ala Arg Leu Lys Asn Asn Asn Arg 
        35                  40                  45              


Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Xaa Tyr Leu Glu 
    50                  55                  60                  


Lys Ala Leu Asn Lys Gly Arg Arg Glu Glu Lys Val Gly Lys Lys Glu 
65                  70                  75                  80  


Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys Ala Ala Gln Lys 
                85                  90                  95      


Arg Lys Asn 
            


<210>  16
<211>  99
<212>  PRT
<213>  artificial

<220>
<223>  SDF-1 Mutant


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Lys or Pro

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Pro or Gly

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Leu, Arg, His or Lys

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is Arg, His or Lys

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa is Arg, His or Lys

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa is Asn, Arg, His or Lys

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is Arg, His or Lys

<400>  16

Met Xaa Xaa Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu 
1               5                   10                  15      


Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Xaa Asn Thr 
            20                  25                  30          


Pro Asn Cys Ala Leu Gln Ile Xaa Ala Arg Leu Lys Asn Asn Asn Arg 
        35                  40                  45              


Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Xaa Tyr Leu Glu 
    50                  55                  60                  


Lys Ala Leu Xaa Xaa Gly Arg Arg Glu Glu Lys Val Gly Lys Lys Glu 
65                  70                  75                  80  


Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys Ala Ala Gln Lys 
                85                  90                  95      


Arg Lys Asn 
            


<210>  17
<211>  99
<212>  PRT
<213>  artificial

<220>
<223>  SDF-1 mutant


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arg, Lys or His

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is Arg, Lys or His

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  Xaa is Arg, Lys or His

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa is Arg, Lys or His

<400>  17

Met Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu 
1               5                   10                  15      


Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Xaa Asn Thr 
            20                  25                  30          


Pro Asn Cys Ala Leu Gln Ile Xaa Ala Arg Leu Lys Asn Asn Asn Arg 
        35                  40                  45              


Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Xaa Tyr Leu Glu 
    50                  55                  60                  


Lys Ala Leu Asn Lys Gly Arg Arg Glu Glu Lys Val Gly Lys Lys Glu 
65                  70                  75                  80  


Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys Ala Ala Gln Lys 
                85                  90                  95      


Arg Lys Asn 
            


<210>  18
<211>  99
<212>  PRT
<213>  artificial

<220>
<223>  SDF-1 mutant


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Leu, Arg, Lys or His

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is Val, Arg, Lys or His

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa is Arg, Lys or His

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa is Asn,  Arg, Lys or His

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is Arg, Lys or His

<400>  18

Met Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu 
1               5                   10                  15      


Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Xaa Asn Thr 
            20                  25                  30          


Pro Asn Cys Ala Leu Gln Ile Xaa Ala Arg Leu Lys Asn Asn Asn Arg 
        35                  40                  45              


Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Xaa Tyr Leu Glu 
    50                  55                  60                  


Lys Ala Leu Xaa Xaa Gly Arg Arg Glu Glu Lys Val Gly Lys Lys Glu 
65                  70                  75                  80  


Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys Ala Ala Gln Lys 
                85                  90                  95      


Arg Lys Asn 
            


