                         SEQUENCE LISTING

<110>  Roche Diagnostics GmbH
       F. Hoffmann-LaRoche AG
 
<120>  An antibody specifically binding to neuropilin-1

<130>  27379 WO

<150>  EP11173464
<151>  2011-07-11

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  2
<211>  17
<212>  PRT
<213>  partial sequence of NRP-1

<400>  2

Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  7
<212>  PRT
<213>  partial sequence of NRP-1

<400>  3

Ser Val Leu Thr Ser Lys Thr 
1               5           


<210>  4
<211>  8
<212>  PRT
<213>  partial sequence of NRP-1

<400>  4

Trp Ser Val Leu Thr Ser Lys Thr 
1               5               


<210>  5
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  5

Asp Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  6

Asn His Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  7

His Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  8

Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  9

Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  10

Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  11

Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  12

Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  13

Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
1               5                   10                  15  


<210>  14
<211>  12
<212>  PRT
<213>  partial sequence of NRP-1

<400>  14

Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser 
1               5                   10          


<210>  15
<211>  20
<212>  PRT
<213>  partial sequence of NRP-1

<400>  15

Ser His Val Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu 
1               5                   10                  15      


Glu Tyr Asp Gln 
            20  


<210>  16
<211>  15
<212>  PRT
<213>  partial sequence of NRP-1

<400>  16

Tyr Asp Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His 
1               5                   10                  15  


