                         SEQUENCE LISTING

<110>  Centre Lon Brard
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       UNIVERSITE CLAUDE BERNARD LYON 1
        
<120>  PLA2R1 as anti-tumoral compound and as biomarker for the 
       detection of cancer

<130>  D29662

<150>  EP 11305885.3    
<151>  2011-07-08

<150>  US 61/507,887    
<151>  2011-07-08

<160>  16    

<170>  PatentIn version 3.3

<210>  1
<211>  4392
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(4389)

<400>  1
atg ctg ctg tcg ccg tcg ctg ctg ctg ctg ctg ctg ctg ggg gcg ccg       48
Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro         
1               5                   10                  15              

cgg ggc tgc gcc gag ggt gtg gcg gcg gcg ctt acc ccc gag cgg ctc       96
Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu         
            20                  25                  30                  

ctg gag tgg cag gat aaa gga ata ttt gtt atc caa agt gag agt ctc      144
Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu         
        35                  40                  45                      

aag aaa tgc att caa gca ggt aaa tcg gtt ctg acc ctg gag aac tgc      192
Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys         
    50                  55                  60                          

aag caa gca aac aag cac atg ctg tgg aaa tgg gtt tca aac cat ggc      240
Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly         
65                  70                  75                  80          

ctc ttt aac ata gga ggc agc ggt tgc ctg ggc ctg aat ttc tcc gcc      288
Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala         
                85                  90                  95              

cca gag cag cca tta agc tta tat gaa tgt gac tcc acc ctc gtt tcc      336
Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser         
            100                 105                 110                 

tta cgg tgg cgc tgt aac agg aag atg atc aca ggc ccg ctg cag tac      384
Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr         
        115                 120                 125                     

tct gtc cag gtg gcg cat gac aac aca gtg gtg gcc tca cgg aag tat      432
Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr         
    130                 135                 140                         

att cat aag tgg att tct tat ggg tca ggt ggt gga gac att tgt gaa      480
Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu         
145                 150                 155                 160         

tat cta cac aaa gat ttg cat aca atc aaa ggg aac acc cac ggg atg      528
Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met         
                165                 170                 175             

ccg tgt atg ttt ccc ttc cag tat aac cat cag tgg cat cat gaa tgt      576
Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys         
            180                 185                 190                 

acc cgt gaa ggt cgg gaa gat gac tta ctg tgg tgt gcc acg aca agc      624
Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser         
        195                 200                 205                     

cgt tat gaa aga gat gaa aag tgg gga ttt tgc cct gat ccc acc tct      672
Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser         
    210                 215                 220                         

gca gaa gta ggt tgt gat act att tgg gag aag gac ctc aat tca cac      720
Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His         
225                 230                 235                 240         

att tgc tac cag ttc aac ctg ctt tca tct ctc tct tgg agt gag gca      768
Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala         
                245                 250                 255             

cat tct tca tgc cag atg caa gga ggt acg ctg tta agt att aca gat      816
His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp         
            260                 265                 270                 

gaa act gaa gaa aat ttc ata agg gag cac atg agc agt aaa aca gtg      864
Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val         
        275                 280                 285                     

gag gtg tgg gtg ggc ctc aat cag ctg gat gaa gac gct ggc tgg cag      912
Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln         
    290                 295                 300                         

tgg tct gat gga acg ccg ctc aac tat ctg aat tgg agc cca gag gta      960
Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val         
305                 310                 315                 320         

aat ttt gag cca ttt gtt gaa gat cac tgt gga aca ttt agt tca ttt     1008
Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe         
                325                 330                 335             

atg cca agt gcc tgg agg agt cgg gat tgt gag tcc acc ttg cca tat     1056
Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr         
            340                 345                 350                 

ata tgt aaa aaa tat cta aac cac att gat cat gaa ata gtt gaa aaa     1104
Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys         
        355                 360                 365                     

gat gcg tgg aaa tat tat gct acc cac tgt gag cct ggc tgg aat ccc     1152
Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro         
    370                 375                 380                         

tac aat cgt aat tgc tac aaa ctt cag aaa gaa gaa aag acc tgg cat     1200
Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His         
385                 390                 395                 400         

gag gct ctg cgt tct tgt cag gct gat aac agt gca tta ata gac ata     1248
Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile         
                405                 410                 415             

acc tca tta gca gag gtg gag ttt ctt gta acc ctc ctt gga gat gaa     1296
Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu         
            420                 425                 430                 

aat gca tca gaa aca tgg att ggt ttg agc agc aat aaa att cca gtt     1344
Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val         
        435                 440                 445                     

tcc ttt gaa tgg tct aat gac tct tca gtc atc ttt act aat tgg cac     1392
Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His         
    450                 455                 460                         

aca ctt gag ccc cac att ttt cca aat aga agc cag ctg tgt gtc tca     1440
Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser         
465                 470                 475                 480         

gca gag cag tct gag gga cac tgg aaa gtc aaa aat tgt gaa gaa aga     1488
Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg         
                485                 490                 495             

ctt ttt tac att tgt aaa aaa gca ggc cat gtc ctc tct gat gct gaa     1536
Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu         
            500                 505                 510                 

tca gga tgt caa gag gga tgg gag aga cat ggt gga ttc tgt tac aaa     1584
Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys         
        515                 520                 525                     

att gac aca gtc ctt cga agc ttt gac caa gct tcc agc ggt tat tac     1632
Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr         
    530                 535                 540                         

tgt cct cct gca ctt gta acc att aca aac agg ttt gaa cag gct ttt     1680
Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe         
545                 550                 555                 560         

att acc agt ttg atc agt agt gtg gta aaa atg aag gac agt tat ttt     1728
Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe         
                565                 570                 575             

tgg ata gct ctt cag gac caa aat gat acg gga gaa tac act tgg aag     1776
Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys         
            580                 585                 590                 

cca gta ggg cag aaa ccc gag ccg gtg cag tac aca cac tgg aac aca     1824
Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr         
        595                 600                 605                     

cac cag ccg cgc tac agt ggt ggc tgt gtt gcc atg cga gga agg cat     1872
His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His         
    610                 615                 620                         

cca ctt ggt cgc tgg gaa gtg aag cac tgt cgg cac ttt aag gca atg     1920
Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met         
625                 630                 635                 640         

tcc ttg tgc aag cag cca gtt gaa aat cag gaa aaa gca gag tat gaa     1968
Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu         
                645                 650                 655             

gag aga tgg ccc ttt cac ccc tgc tat ttg gac tgg gag tca gag cct     2016
Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro         
            660                 665                 670                 

ggt ctg gcc agt tgc ttc aag gta ttt cat agt gaa aaa gtt ctg atg     2064
Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met         
        675                 680                 685                     

aaa aga aca tgg aga gaa gct gaa gca ttt tgc gaa gaa ttt gga gct     2112
Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala         
    690                 695                 700                         

cat ctt gca agc ttt gcc cat att gag gaa gag aat ttt gtg aat gag     2160
His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu         
705                 710                 715                 720         

ctc tta cat tca aaa ttt aat tgg aca gaa gaa agg cag ttc tgg att     2208
Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile         
                725                 730                 735             

gga ttt aat aaa aga aac cca ctg aat gcc ggc tca tgg gag tgg tct     2256
Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser         
            740                 745                 750                 

gat aga act cct gtt gtc tct tcg ttt tta gac aac act tat ttt gga     2304
Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly         
        755                 760                 765                     

gaa gat gca aga aac tgt gct gtt tat aag gca aac aaa aca ttg ctg     2352
Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu         
    770                 775                 780                         

ccc tta cac tgt ggt tcc aaa cgt gaa tgg ata tgc aaa atc cca aga     2400
Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg         
785                 790                 795                 800         

gat gtg aaa ccc aag att ccg ttc tgg tac cag tac gat gta ccc tgg     2448
Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp         
                805                 810                 815             

ctc ttt tat cag gat gca gaa tac ctt ttt cat acc ttt gcc tca gaa     2496
Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu         
            820                 825                 830                 

tgg ttg aac ttt gag ttt gtc tgt agc tgg ctg cac agt gat ctt ctc     2544
Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu         
        835                 840                 845                     

aca att cat tct gca cat gag caa gaa ttc atc cac agc aaa ata aaa     2592
Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys         
    850                 855                 860                         

gcg cta tca aag tat ggt gca agt tgg tgg att gga ctt caa gaa gaa     2640
Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu         
865                 870                 875                 880         

aga gcc aat gat gaa ttt cgc tgg aga gat gga aca cca gtg ata tac     2688
Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr         
                885                 890                 895             

cag aac tgg gac aca gga aga gaa aga act gtg aat aat cag agc cag     2736
Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln         
            900                 905                 910                 

aga tgt ggc ttt att tct tct ata aca gga ctc tgg ggt agt gaa gag     2784
Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu         
        915                 920                 925                     

tgt tca gtt tct atg cct agt atc tgt aag cga aaa aag gtt tgg ctc     2832
Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu         
    930                 935                 940                         

ata gag aaa aag aaa gat aca cca aaa caa cat gga acg tgt ccc aaa     2880
Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys         
945                 950                 955                 960         

gga tgg cta tat ttt aac tat aag tgc ctt ctg ctg aat atc ccc aaa     2928
Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys         
                965                 970                 975             

gac cca agc agt tgg aag aac tgg acg cat gct caa cat ttc tgt gct     2976
Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala         
            980                 985                 990                 

gaa gaa ggg ggg acc ctg gtc gcc  att gaa agt gag gtg  gag caa gct   3024
Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala       
        995                 1000                 1005                   

ttc att  act atg aat ctt ttt  ggc cag acc acc agt  gtg tgg ata      3069
Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile          
    1010                 1015                 1020                      

ggt tta  caa aat gat gat tat  gaa aca tgg cta aat  gga aag cct      3114
Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro          
    1025                 1030                 1035                      

gtg gta  tat tct aac tgg tct  cca ttt gat ata ata  aat att cca      3159
Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro          
    1040                 1045                 1050                      

agt cac  aat acc act gaa gtt  cag aaa cac att cct  ctc tgt gcc      3204
Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala          
    1055                 1060                 1065                      

tta ctc  tca agt aat cct aat  ttt cat ttc act gga  aaa tgg tat      3249
Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr          
    1070                 1075                 1080                      

ttt gaa  gac tgt gga aag gaa  ggc tat ggg ttt gtt  tgt gaa aaa      3294
Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys          
    1085                 1090                 1095                      

atg caa  gat act tct gga cac  ggt gta aat aca tct  gat atg tat      3339
Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr          
    1100                 1105                 1110                      

cca atg  ccc aat acc tta gaa  tat gga aac aga act  tac aaa ata      3384
Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile          
    1115                 1120                 1125                      

att aat  gca aat atg act tgg  tat gca gca ata aaa  acc tgc ctg      3429
Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu          
    1130                 1135                 1140                      

atg cac  aaa gca caa ctg gtc  agc atc aca gac cag  tat cac cag      3474
Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln          
    1145                 1150                 1155                      

tcc ttc  ctc act gtt gtc ctc  aac cgg cta gga tat  gcc cac tgg      3519
Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp          
    1160                 1165                 1170                      

att gga  ctg ttc acc aca gat  aat ggt ctt aat ttt  gac tgg tct      3564
Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser          
    1175                 1180                 1185                      

gat ggc  acc aaa tct tct ttc  act ttt tgg aaa gat  gag gag tcc      3609
Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser          
    1190                 1195                 1200                      

tcc ctc  ctt ggt gac tgc gtt  ttt gcc gac agc aac  gga cgc tgg      3654
Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp          
    1205                 1210                 1215                      

cat agc  aca gcc tgc gag tca  ttt ctg caa ggt gcc  att tgt cat      3699
His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His          
    1220                 1225                 1230                      

gtg cca  cct gaa aca aga caa  tct gaa cac cca gag  ttg tgc tca      3744
Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser          
    1235                 1240                 1245                      

gaa aca  tct att ccc tgg ata  aaa ttt aaa agt aat  tgc tac agt      3789
Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser          
    1250                 1255                 1260                      

ttt tct  aca gtc cta gac agt  atg agt ttt gag gct  gct cat gaa      3834
Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu          
    1265                 1270                 1275                      

ttt tgc  aaa aag gaa ggt tct  aat ctt tta aca atc  aag gat gag      3879
Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu          
    1280                 1285                 1290                      

gct gaa  aat gca ttt ctc cta  gaa gag ctg ttt gct  ttt ggt tct      3924
Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser          
    1295                 1300                 1305                      

tct gtc  cag atg gtt tgg ttg  aat gct caa ttt gat  ggt aac aat      3969
Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn          
    1310                 1315                 1320                      

gaa acc  ata aag tgg ttt gat  gga act ccc aca gac  cag tca aac      4014
Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn          
    1325                 1330                 1335                      

tgg ggc  att cgg aag cca gac  aca gac tac ttc aag  ccc cat cat      4059
Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His          
    1340                 1345                 1350                      

tgt gtt  gcc ttg agg atc cct  gaa gga tta tgg cag  cta tcc ccg      4104
Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro          
    1355                 1360                 1365                      

tgt caa  gaa aaa aaa ggc ttt  ata tgt aaa atg gag  gca gat att      4149
Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile          
    1370                 1375                 1380                      

cac act  gca gag gcg ctg cca  gaa aaa gga cca agt  cac agc atc      4194
His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile          
    1385                 1390                 1395                      

att cct  ctt gcg gtt gta ctg  aca ctg ata gtc att  gtg gcc att      4239
Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile          
    1400                 1405                 1410                      

tgc aca  ctt tcc ttc tgc ata  tac aag cat aac ggt  ggc ttc ttc      4284
Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe          
    1415                 1420                 1425                      

agg aga  ctt gca ggg ttt cgg  aat cct tac tat cct  gca acc aac      4329
Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn          
    1430                 1435                 1440                      

ttt agt  aca gta tat tta gaa  gaa aat att ctc att  tct gat ctt      4374
Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu          
    1445                 1450                 1455                      

gag aag  agt gac caa taa                                            4392
Glu Lys  Ser Asp Gln                                                    
    1460                                                                


<210>  2
<211>  1463
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210>  3
<211>  3969
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3966)

<400>  3
atg ctg ctg tcg ccg tcg ctg ctg ctg ctg ctg ctg ctg ggg gcg ccg       48
Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro         
1               5                   10                  15              

cgg ggc tgc gcc gag ggt gtg gcg gcg gcg ctt acc ccc gag cgg ctc       96
Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu         
            20                  25                  30                  

ctg gag tgg cag gat aaa gga ata ttt gtt atc caa agt gag agt ctc      144
Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu         
        35                  40                  45                      

aag aaa tgc att caa gca ggt aaa tcg gtt ctg acc ctg gag aac tgc      192
Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys         
    50                  55                  60                          

aag caa gca aac aag cac atg ctg tgg aaa tgg gtt tca aac cat ggc      240
Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly         
65                  70                  75                  80          

ctc ttt aac ata gga ggc agc ggt tgc ctg ggc ctg aat ttc tcc gcc      288
Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala         
                85                  90                  95              

cca gag cag cca tta agc tta tat gaa tgt gac tcc acc ctc gtt tcc      336
Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser         
            100                 105                 110                 

tta cgg tgg cgc tgt aac agg aag atg atc aca ggc ccg ctg cag tac      384
Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr         
        115                 120                 125                     

tct gtc cag gtg gcg cat gac aac aca gtg gtg gcc tca cgg aag tat      432
Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr         
    130                 135                 140                         

att cat aag tgg att tct tat ggg tca ggt ggt gga gac att tgt gaa      480
Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu         
145                 150                 155                 160         

tat cta cac aaa gat ttg cat aca atc aaa ggg aac acc cac ggg atg      528
Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met         
                165                 170                 175             

ccg tgt atg ttt ccc ttc cag tat aac cat cag tgg cat cat gaa tgt      576
Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys         
            180                 185                 190                 

acc cgt gaa ggt cgg gaa gat gac tta ctg tgg tgt gcc acg aca agc      624
Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser         
        195                 200                 205                     

cgt tat gaa aga gat gaa aag tgg gga ttt tgc cct gat ccc acc tct      672
Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser         
    210                 215                 220                         

gca gaa gta ggt tgt gat act att tgg gag aag gac ctc aat tca cac      720
Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His         
225                 230                 235                 240         

att tgc tac cag ttc aac ctg ctt tca tct ctc tct tgg agt gag gca      768
Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala         
                245                 250                 255             

cat tct tca tgc cag atg caa gga ggt acg ctg tta agt att aca gat      816
His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp         
            260                 265                 270                 

gaa act gaa gaa aat ttc ata agg gag cac atg agc agt aaa aca gtg      864
Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val         
        275                 280                 285                     

gag gtg tgg gtg ggc ctc aat cag ctg gat gaa gac gct ggc tgg cag      912
Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln         
    290                 295                 300                         

tgg tct gat gga acg ccg ctc aac tat ctg aat tgg agc cca gag gta      960
Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val         
305                 310                 315                 320         

aat ttt gag cca ttt gtt gaa gat cac tgt gga aca ttt agt tca ttt     1008
Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe         
                325                 330                 335             

atg cca agt gcc tgg agg agt cgg gat tgt gag tcc acc ttg cca tat     1056
Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr         
            340                 345                 350                 

ata tgt aaa aaa tat cta aac cac att gat cat gaa ata gtt gaa aaa     1104
Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys         
        355                 360                 365                     

gat gcg tgg aaa tat tat gct acc cac tgt gag cct ggc tgg aat ccc     1152
Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro         
    370                 375                 380                         

tac aat cgt aat tgc tac aaa ctt cag aaa gaa gaa aag acc tgg cat     1200
Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His         
385                 390                 395                 400         

gag gct ctg cgt tct tgt cag gct gat aac agt gca tta ata gac ata     1248
Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile         
                405                 410                 415             

acc tca tta gca gag gtg gag ttt ctt gta acc ctc ctt gga gat gaa     1296
Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu         
            420                 425                 430                 

aat gca tca gaa aca tgg att ggt ttg agc agc aat aaa att cca gtt     1344
Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val         
        435                 440                 445                     

tcc ttt gaa tgg tct aat gac tct tca gtc atc ttt act aat tgg cac     1392
Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His         
    450                 455                 460                         

aca ctt gag ccc cac att ttt cca aat aga agc cag ctg tgt gtc tca     1440
Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser         
465                 470                 475                 480         

gca gag cag tct gag gga cac tgg aaa gtc aaa aat tgt gaa gaa aga     1488
Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg         
                485                 490                 495             

ctt ttt tac att tgt aaa aaa gca ggc cat gtc ctc tct gat gct gaa     1536
Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu         
            500                 505                 510                 

tca gga tgt caa gag gga tgg gag aga cat ggt gga ttc tgt tac aaa     1584
Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys         
        515                 520                 525                     

att gac aca gtc ctt cga agc ttt gac caa gct tcc agc ggt tat tac     1632
Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr         
    530                 535                 540                         

tgt cct cct gca ctt gta acc att aca aac agg ttt gaa cag gct ttt     1680
Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe         
545                 550                 555                 560         

att acc agt ttg atc agt agt gtg gta aaa atg aag gac agt tat ttt     1728
Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe         
                565                 570                 575             

tgg ata gct ctt cag gac caa aat gat acg gga gaa tac act tgg aag     1776
Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys         
            580                 585                 590                 

cca gta ggg cag aaa ccc gag ccg gtg cag tac aca cac tgg aac aca     1824
Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr         
        595                 600                 605                     

cac cag ccg cgc tac agt ggt ggc tgt gtt gcc atg cga gga agg cat     1872
His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His         
    610                 615                 620                         

cca ctt ggt cgc tgg gaa gtg aag cac tgt cgg cac ttt aag gca atg     1920
Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met         
625                 630                 635                 640         

tcc ttg tgc aag cag cca gtt gaa aat cag gaa aaa gca gag tat gaa     1968
Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu         
                645                 650                 655             

gag aga tgg ccc ttt cac ccc tgc tat ttg gac tgg gag tca gag cct     2016
Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro         
            660                 665                 670                 

ggt ctg gcc agt tgc ttc aag gta ttt cat agt gaa aaa gtt ctg atg     2064
Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met         
        675                 680                 685                     

aaa aga aca tgg aga gaa gct gaa gca ttt tgc gaa gaa ttt gga gct     2112
Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala         
    690                 695                 700                         

cat ctt gca agc ttt gcc cat att gag gaa gag aat ttt gtg aat gag     2160
His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu         
705                 710                 715                 720         

ctc tta cat tca aaa ttt aat tgg aca gaa gaa agg cag ttc tgg att     2208
Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile         
                725                 730                 735             

gga ttt aat aaa aga aac cca ctg aat gcc ggc tca tgg gag tgg tct     2256
Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser         
            740                 745                 750                 

gat aga act cct gtt gtc tct tcg ttt tta gac aac act tat ttt gga     2304
Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly         
        755                 760                 765                     

gaa gat gca aga aac tgt gct gtt tat aag gca aac aaa aca ttg ctg     2352
Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu         
    770                 775                 780                         

ccc tta cac tgt ggt tcc aaa cgt gaa tgg ata tgc aaa atc cca aga     2400
Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg         
785                 790                 795                 800         

gat gtg aaa ccc aag att ccg ttc tgg tac cag tac gat gta ccc tgg     2448
Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp         
                805                 810                 815             

ctc ttt tat cag gat gca gaa tac ctt ttt cat acc ttt gcc tca gaa     2496
Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu         
            820                 825                 830                 

tgg ttg aac ttt gag ttt gtc tgt agc tgg ctg cac agt gat ctt ctc     2544
Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu         
        835                 840                 845                     

aca att cat tct gca cat gag caa gaa ttc atc cac agc aaa ata aaa     2592
Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys         
    850                 855                 860                         

gcg cta tca aag tat ggt gca agt tgg tgg att gga ctt caa gaa gaa     2640
Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu         
865                 870                 875                 880         

aga gcc aat gat gaa ttt cgc tgg aga gat gga aca cca gtg ata tac     2688
Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr         
                885                 890                 895             

cag aac tgg gac aca gga aga gaa aga act gtg aat aat cag agc cag     2736
Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln         
            900                 905                 910                 

aga tgt ggc ttt att tct tct ata aca gga ctc tgg ggt agt gaa gag     2784
Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu         
        915                 920                 925                     

tgt tca gtt tct atg cct agt atc tgt aag cga aaa aag gtt tgg ctc     2832
Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu         
    930                 935                 940                         

ata gag aaa aag aaa gat aca cca aaa caa cat gga acg tgt ccc aaa     2880
Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys         
945                 950                 955                 960         

gga tgg cta tat ttt aac tat aag tgc ctt ctg ctg aat atc ccc aaa     2928
Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys         
                965                 970                 975             

gac cca agc agt tgg aag aac tgg acg cat gct caa cat ttc tgt gct     2976
Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala         
            980                 985                 990                 

gaa gaa ggg ggg acc ctg gtc gcc  att gaa agt gag gtg  gag caa gct   3024
Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala       
        995                 1000                 1005                   

ttc att  act atg aat ctt ttt  ggc cag acc acc agt  gtg tgg ata      3069
Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile          
    1010                 1015                 1020                      

ggt tta  caa aat gat gat tat  gaa aca tgg cta aat  gga aag cct      3114
Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro          
    1025                 1030                 1035                      

gtg gta  tat tct aac tgg tct  cca ttt gat ata ata  aat att cca      3159
Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro          
    1040                 1045                 1050                      

agt cac  aat acc act gaa gtt  cag aaa cac att cct  ctc tgt gcc      3204
Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala          
    1055                 1060                 1065                      

tta ctc  tca agt aat cct aat  ttt cat ttc act gga  aaa tgg tat      3249
Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr          
    1070                 1075                 1080                      

ttt gaa  gac tgt gga aag gaa  ggc tat ggg ttt gtt  tgt gaa aaa      3294
Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys          
    1085                 1090                 1095                      

atg caa  gat act tct gga cac  ggt gta aat aca tct  gat atg tat      3339
Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr          
    1100                 1105                 1110                      

cca atg  ccc aat acc tta gaa  tat gga aac aga act  tac aaa ata      3384
Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile          
    1115                 1120                 1125                      

att aat  gca aat atg act tgg  tat gca gca ata aaa  acc tgc ctg      3429
Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu          
    1130                 1135                 1140                      

atg cac  aaa gca caa ctg gtc  agc atc aca gac cag  tat cac cag      3474
Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln          
    1145                 1150                 1155                      

tcc ttc  ctc act gtt gtc ctc  aac cgg cta gga tat  gcc cac tgg      3519
Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp          
    1160                 1165                 1170                      

att gga  ctg ttc acc aca gat  aat ggt ctt aat ttt  gac tgg tct      3564
Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser          
    1175                 1180                 1185                      

gat ggc  acc aaa tct tct ttc  act ttt tgg aaa gat  gag gag tcc      3609
Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser          
    1190                 1195                 1200                      

tcc ctc  ctt ggt gac tgc gtt  ttt gcc gac agc aac  gga cgc tgg      3654
Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp          
    1205                 1210                 1215                      

cat agc  aca gcc tgc gag tca  ttt ctg caa ggt gcc  att tgt cat      3699
His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His          
    1220                 1225                 1230                      

gtg cca  cct gaa aca aga caa  tct gaa cac cca gag  ttg tgc tca      3744
Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser          
    1235                 1240                 1245                      

gaa aca  tct att ccc tgg ata  aaa ttt aaa agt aat  tgc tac agt      3789
Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser          
    1250                 1255                 1260                      

ttt tct  aca gtc cta gac agt  atg agt ttt gag gct  gct cat gaa      3834
Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu          
    1265                 1270                 1275                      

ttt tgc  aaa aag gaa ggt tct  aat ctt tta aca atc  aag gat gag      3879
Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu          
    1280                 1285                 1290                      

gct gaa  aat gca ttt ctc cta  gaa gag ctg ttt gct  ttt ggt tct      3924
Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser          
    1295                 1300                 1305                      

tct gtc  cag atg gtt tgg ttg  aat gct caa ttt gat  ggt aac taa      3969
Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn              
    1310                 1315                 1320                      


<210>  4
<211>  1322
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn 
    1310                 1315                 1320         


<210>  5
<211>  3297
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3294)

<400>  5
atg ctg ctg tcg ccg tcg ctg ctg ctg ctg ctg ctg ctg ggg gcg ccg       48
Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro         
1               5                   10                  15              

cgg ggc tgc gcc gag ggt gtg gcg gcg gcg ctt acc ccc gag cgg ctc       96
Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu         
            20                  25                  30                  

ctg gag tgg cag gat aaa gga ata ttt gtt atc caa agt gag agt ctc      144
Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu         
        35                  40                  45                      

aag aaa tgc att caa gca ggt aaa tcg gtt ctg acc ctg gag aac tgc      192
Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys         
    50                  55                  60                          

aag caa gca aac aag cac atg ctg tgg aaa tgg gtt tca aac cat ggc      240
Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly         
65                  70                  75                  80          

ctc ttt aac ata gga ggc agc ggt tgc ctg ggc ctg aat ttc tcc gcc      288
Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala         
                85                  90                  95              

cca gag cag cca tta agc tta tat gaa tgt gac tcc acc ctc gtt tcc      336
Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser         
            100                 105                 110                 

tta cgg tgg cgc tgt aac agg aag atg atc aca ggc ccg ctg cag tac      384
Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr         
        115                 120                 125                     

tct gtc cag gtg gcg cat gac aac aca gtg gtg gcc tca cgg aag tat      432
Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr         
    130                 135                 140                         

att cat aag tgg att tct tat ggg tca ggt ggt gga gac att tgt gaa      480
Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu         
145                 150                 155                 160         

tat cta cac aaa gat ttg cat aca atc aaa ggg aac acc cac ggg atg      528
Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met         
                165                 170                 175             

ccg tgt atg ttt ccc ttc cag tat aac cat cag tgg cat cat gaa tgt      576
Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys         
            180                 185                 190                 

acc cgt gaa ggt cgg gaa gat gac tta ctg tgg tgt gcc acg aca agc      624
Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser         
        195                 200                 205                     

cgt tat gaa aga gat gaa aag tgg gga ttt tgc cct gat ccc acc tct      672
Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser         
    210                 215                 220                         

gca gaa gta ggt tgt gat act att tgg gag aag gac ctc aat tca cac      720
Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His         
225                 230                 235                 240         

att tgc tac cag ttc aac ctg ctt tca tct ctc tct tgg agt gag gca      768
Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala         
                245                 250                 255             

cat tct tca tgc cag atg caa gga ggt acg ctg tta agt att aca gat      816
His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp         
            260                 265                 270                 

gaa act gaa gaa aat ttc ata agg gag cac atg agc agt aaa aca gtg      864
Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val         
        275                 280                 285                     

gag gtg tgg gtg ggc ctc aat cag ctg gat gaa gac gct ggc tgg cag      912
Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln         
    290                 295                 300                         

tgg tct gat gga acg ccg ctc aac tat ctg aat tgg agc cca gag gta      960
Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val         
305                 310                 315                 320         

aat ttt gag cca ttt gtt gaa gat cac tgt gga aca ttt agt tca ttt     1008
Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe         
                325                 330                 335             

atg cca agt gcc tgg agg agt cgg gat tgt gag tcc acc ttg cca tat     1056
Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr         
            340                 345                 350                 

ata tgt aaa aaa tat cta aac cac att gat cat gaa ata gtt gaa aaa     1104
Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys         
        355                 360                 365                     

gat gcg tgg aaa tat tat gct acc cac tgt gag cct ggc tgg aat ccc     1152
Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro         
    370                 375                 380                         

tac aat cgt aat tgc tac aaa ctt cag aaa gaa gaa aag acc tgg cat     1200
Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His         
385                 390                 395                 400         

gag gct ctg cgt tct tgt cag gct gat aac agt gca tta ata gac ata     1248
Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile         
                405                 410                 415             

acc tca tta gca gag gtg gag ttt ctt gta acc ctc ctt gga gat gaa     1296
Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu         
            420                 425                 430                 

aat gca tca gaa aca tgg att ggt ttg agc agc aat aaa att cca gtt     1344
Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val         
        435                 440                 445                     

tcc ttt gaa tgg tct aat gac tct tca gtc atc ttt act aat tgg cac     1392
Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His         
    450                 455                 460                         

aca ctt gag ccc cac att ttt cca aat aga agc cag ctg tgt gtc tca     1440
Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser         
465                 470                 475                 480         

gca gag cag tct gag gga cac tgg aaa gtc aaa aat tgt gaa gaa aga     1488
Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg         
                485                 490                 495             

ctt ttt tac att tgt aaa aaa gca ggc cat gtc ctc tct gat gct gaa     1536
Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu         
            500                 505                 510                 

tca gga tgt caa gag gga tgg gag aga cat ggt gga ttc tgt tac aaa     1584
Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys         
        515                 520                 525                     

att gac aca gtc ctt cga agc ttt gac caa gct tcc agc ggt tat tac     1632
Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr         
    530                 535                 540                         

tgt cct cct gca ctt gta acc att aca aac agg ttt gaa cag gct ttt     1680
Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe         
545                 550                 555                 560         

att acc agt ttg atc agt agt gtg gta aaa atg aag gac agt tat ttt     1728
Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe         
                565                 570                 575             

tgg ata gct ctt cag gac caa aat gat acg gga gaa tac act tgg aag     1776
Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys         
            580                 585                 590                 

cca gta ggg cag aaa ccc gag ccg gtg cag tac aca cac tgg aac aca     1824
Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr         
        595                 600                 605                     

cac cag ccg cgc tac agt ggt ggc tgt gtt gcc atg cga gga agg cat     1872
His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His         
    610                 615                 620                         

cca ctt ggt cgc tgg gaa gtg aag cac tgt cgg cac ttt aag gca atg     1920
Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met         
625                 630                 635                 640         

tcc ttg tgc aag cag cca gtt gaa aat cag gaa aaa gca gag tat gaa     1968
Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu         
                645                 650                 655             

gag aga tgg ccc ttt cac ccc tgc tat ttg gac tgg gag tca gag cct     2016
Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro         
            660                 665                 670                 

ggt ctg gcc agt tgc ttc aag gta ttt cat agt gaa aaa gtt ctg atg     2064
Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met         
        675                 680                 685                     

aaa aga aca tgg aga gaa gct gaa gca ttt tgc gaa gaa ttt gga gct     2112
Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala         
    690                 695                 700                         

cat ctt gca agc ttt gcc cat att gag gaa gag aat ttt gtg aat gag     2160
His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu         
705                 710                 715                 720         

ctc tta cat tca aaa ttt aat tgg aca gaa gaa agg cag ttc tgg att     2208
Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile         
                725                 730                 735             

gga ttt aat aaa aga aac cca ctg aat gcc ggc tca tgg gag tgg tct     2256
Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser         
            740                 745                 750                 

gat aga act cct gtt gtc tct tcg ttt tta gac aac act tat ttt gga     2304
Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly         
        755                 760                 765                     

gaa gat gca aga aac tgt gct gtt tat aag gca aac aaa aca ttg ctg     2352
Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu         
    770                 775                 780                         

ccc tta cac tgt ggt tcc aaa cgt gaa tgg ata tgc aaa atc cca aga     2400
Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg         
785                 790                 795                 800         

gat gtg aaa ccc aag att ccg ttc tgg tac cag tac gat gta ccc tgg     2448
Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp         
                805                 810                 815             

ctc ttt tat cag gat gca gaa tac ctt ttt cat acc ttt gcc tca gaa     2496
Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu         
            820                 825                 830                 

tgg ttg aac ttt gag ttt gtc tgt agc tgg ctg cac agt gat ctt ctc     2544
Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu         
        835                 840                 845                     

aca att cat tct gca cat gag caa gaa ttc atc cac agc aaa ata aaa     2592
Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys         
    850                 855                 860                         

gcg cta tca aag tat ggt gca agt tgg tgg att gga ctt caa gaa gaa     2640
Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu         
865                 870                 875                 880         

aga gcc aat gat gaa ttt cgc tgg aga gat gga aca cca gtg ata tac     2688
Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr         
                885                 890                 895             

cag aac tgg gac aca gga aga gaa aga act gtg aat aat cag agc cag     2736
Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln         
            900                 905                 910                 

aga tgt ggc ttt att tct tct ata aca gga ctc tgg ggt agt gaa gag     2784
Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu         
        915                 920                 925                     

tgt tca gtt tct atg cct agt atc tgt aag cga aaa aag gtt tgg ctc     2832
Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu         
    930                 935                 940                         

ata gag aaa aag aaa gat aca cca aaa caa cat gga acg tgt ccc aaa     2880
Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys         
945                 950                 955                 960         

gga tgg cta tat ttt aac tat aag tgc ctt ctg ctg aat atc ccc aaa     2928
Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys         
                965                 970                 975             

gac cca agc agt tgg aag aac tgg acg cat gct caa cat ttc tgt gct     2976
Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala         
            980                 985                 990                 

gaa gaa ggg ggg acc ctg gtc gcc  att gaa agt gag gtg  gag caa gct   3024
Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala       
        995                 1000                 1005                   

ttc att  act atg aat ctt ttt  ggc cag acc acc agt  gtg tgg ata      3069
Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile          
    1010                 1015                 1020                      

ggt tta  caa aat gat gat tat  gaa aca tgg cta aat  gga aag cct      3114
Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro          
    1025                 1030                 1035                      

gtg gta  tat tct aac tgg tct  cca ttt gat ata ata  aat att cca      3159
Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro          
    1040                 1045                 1050                      

agt cac  aat acc act gaa gtt  cag aaa cac att cct  ctc tgt gcc      3204
Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala          
    1055                 1060                 1065                      

tta ctc  tca agt aat cct aat  ttt cat ttc act gga  aaa tgg tat      3249
Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr          
    1070                 1075                 1080                      

ttt gaa  gac tgt gga aag gaa  ggc tat ggg ttt gtt  tgt gaa aaa      3294
Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys          
    1085                 1090                 1095                      

taa                                                                 3297


<210>  6
<211>  1098
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


<210>  7
<211>  1938
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1935)

<400>  7
atg ctg ctg tcg ccg tcg ctg ctg ctg ctg ctg ctg ctg ggg gcg ccg       48
Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro         
1               5                   10                  15              

cgg ggc tgc gcc gag ggt gtg gcg gcg gcg ctt acc ccc gag cgg ctc       96
Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu         
            20                  25                  30                  

ctg gag tgg cag gat aaa gga ata ttt gtt atc caa agt gag agt ctc      144
Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu         
        35                  40                  45                      

aag aaa tgc att caa gca ggt aaa tcg gtt ctg acc ctg gag aac tgc      192
Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys         
    50                  55                  60                          

aag caa gca aac aag cac atg ctg tgg aaa tgg gtt tca aac cat ggc      240
Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly         
65                  70                  75                  80          

ctc ttt aac ata gga ggc agc ggt tgc ctg ggc ctg aat ttc tcc gcc      288
Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala         
                85                  90                  95              

cca gag cag cca tta agc tta tat gaa tgt gac tcc acc ctc gtt tcc      336
Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser         
            100                 105                 110                 

tta cgg tgg cgc tgt aac agg aag atg atc aca ggc ccg ctg cag tac      384
Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr         
        115                 120                 125                     

tct gtc cag gtg gcg cat gac aac aca gtg gtg gcc tca cgg aag tat      432
Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr         
    130                 135                 140                         

att cat aag tgg att tct tat ggg tca ggt ggt gga gac att tgt gaa      480
Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu         
145                 150                 155                 160         

tat cta cac aaa gat ttg cat aca atc aaa ggg aac acc cac ggg atg      528
Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met         
                165                 170                 175             

ccg tgt atg ttt ccc ttc cag tat aac cat cag tgg cat cat gaa tgt      576
Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys         
            180                 185                 190                 

acc cgt gaa ggt cgg gaa gat gac tta ctg tgg tgt gcc acg aca agc      624
Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser         
        195                 200                 205                     

cgt tat gaa aga gat gaa aag tgg gga ttt tgc cct gat ccc acc tct      672
Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser         
    210                 215                 220                         

gca gaa gta ggt tgt gat act att tgg gag aag gac ctc aat tca cac      720
Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His         
225                 230                 235                 240         

att tgc tac cag ttc aac ctg ctt tca tct ctc tct tgg agt gag gca      768
Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala         
                245                 250                 255             

cat tct tca tgc cag atg caa gga ggt acg ctg tta agt att aca gat      816
His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp         
            260                 265                 270                 

gaa act gaa gaa aat ttc ata agg gag cac atg agc agt aaa aca gtg      864
Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val         
        275                 280                 285                     

gag gtg tgg gtg ggc ctc aat cag ctg gat gaa gac gct ggc tgg cag      912
Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln         
    290                 295                 300                         

tgg tct gat gga acg ccg ctc aac tat ctg aat tgg agc cca gag gta      960
Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val         
305                 310                 315                 320         

aat ttt gag cca ttt gtt gaa gat cac tgt gga aca ttt agt tca ttt     1008
Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe         
                325                 330                 335             

atg cca agt gcc tgg agg agt cgg gat tgt gag tcc acc ttg cca tat     1056
Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr         
            340                 345                 350                 

ata tgt aaa aaa tat cta aac cac att gat cat gaa ata gtt gaa aaa     1104
Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys         
        355                 360                 365                     

gat gcg tgg aaa tat tat gct acc cac tgt gag cct ggc tgg aat ccc     1152
Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro         
    370                 375                 380                         

tac aat cgt aat tgc tac aaa ctt cag aaa gaa gaa aag acc tgg cat     1200
Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His         
385                 390                 395                 400         

gag gct ctg cgt tct tgt cag gct gat aac agt gca tta ata gac ata     1248
Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile         
                405                 410                 415             

acc tca tta gca gag gtg gag ttt ctt gta acc ctc ctt gga gat gaa     1296
Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu         
            420                 425                 430                 

aat gca tca gaa aca tgg att ggt ttg agc agc aat aaa att cca gtt     1344
Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val         
        435                 440                 445                     

tcc ttt gaa tgg tct aat gac tct tca gtc atc ttt act aat tgg cac     1392
Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His         
    450                 455                 460                         

aca ctt gag ccc cac att ttt cca aat aga agc cag ctg tgt gtc tca     1440
Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser         
465                 470                 475                 480         

gca gag cag tct gag gga cac tgg aaa gtc aaa aat tgt gaa gaa aga     1488
Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg         
                485                 490                 495             

ctt ttt tac att tgt aaa aaa gca ggc cat gtc ctc tct gat gct gaa     1536
Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu         
            500                 505                 510                 

tca gga tgt caa gag gga tgg gag aga cat ggt gga ttc tgt tac aaa     1584
Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys         
        515                 520                 525                     

att gac aca gtc ctt cga agc ttt gac caa gct tcc agc ggt tat tac     1632
Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr         
    530                 535                 540                         

tgt cct cct gca ctt gta acc att aca aac agg ttt gaa cag gct ttt     1680
Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe         
545                 550                 555                 560         

att acc agt ttg atc agt agt gtg gta aaa atg aag gac agt tat ttt     1728
Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe         
                565                 570                 575             

tgg ata gct ctt cag gac caa aat gat acg gga gaa tac act tgg aag     1776
Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys         
            580                 585                 590                 

cca gta ggg cag aaa ccc gag ccg gtg cag tac aca cac tgg aac aca     1824
Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr         
        595                 600                 605                     

cac cag ccg cgc tac agt ggt ggc tgt gtt gcc atg cga gga agg cat     1872
His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His         
    610                 615                 620                         

cca ctt ggt cgc tgg gaa gtg aag cac tgt cgg cac ttt aag gca atg     1920
Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met         
625                 630                 635                 640         

tcc ttg tgc aag cag taa                                             1938
Ser Leu Cys Lys Gln                                                     
                645                                                     


<210>  8
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln 
                645 


<210>  9
<211>  669
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(666)

<400>  9
atg ctg ctg tcg ccg tcg ctg ctg ctg ctg ctg ctg ctg ggg gcg ccg       48
Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro         
1               5                   10                  15              

cgg ggc tgc gcc gag ggt gtg gcg gcg gcg ctt acc ccc gag cgg ctc       96
Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu         
            20                  25                  30                  

ctg gag tgg cag gat aaa gga ata ttt gtt atc caa agt gag agt ctc      144
Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu         
        35                  40                  45                      

aag aaa tgc att caa gca ggt aaa tcg gtt ctg acc ctg gag aac tgc      192
Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys         
    50                  55                  60                          

aag caa gca aac aag cac atg ctg tgg aaa tgg gtt tca aac cat ggc      240
Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly         
65                  70                  75                  80          

ctc ttt aac ata gga ggc agc ggt tgc ctg ggc ctg aat ttc tcc gcc      288
Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala         
                85                  90                  95              

cca gag cag cca tta agc tta tat gaa tgt gac tcc acc ctc gtt tcc      336
Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser         
            100                 105                 110                 

tta cgg tgg cgc tgt aac agg aag atg atc aca ggc ccg ctg cag tac      384
Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr         
        115                 120                 125                     

tct gtc cag gtg gcg cat gac aac aca gtg gtg gcc tca cgg aag tat      432
Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr         
    130                 135                 140                         

att cat aag tgg att tct tat ggg tca ggt ggt gga gac att tgt gaa      480
Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu         
145                 150                 155                 160         

tat cta cac aaa gat ttg cat aca atc aaa ggg aac acc cac ggg atg      528
Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met         
                165                 170                 175             

ccg tgt atg ttt ccc ttc cag tat aac cat cag tgg cat cat gaa tgt      576
Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys         
            180                 185                 190                 

acc cgt gaa ggt cgg gaa gat gac tta ctg tgg tgt gcc acg aca agc      624
Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser         
        195                 200                 205                     

cgt tat gaa aga gat gaa aag tgg gga ttt tgc cct gat ccc taa          669
Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro                 
    210                 215                 220                         


<210>  10
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro 
    210                 215                 220         


<210>  11
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  11
tactcgagcc accatgctgc tgtcgccgtc gctg                                 34


<210>  12
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  WT reverse primer

<400>  12
tagcggccgc ttattggtca ctcttctcaa gatc                                 34


<210>  13
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  FNII reverse primer

<400>  13
tagcggccgc ttagggatca gggcaaaatc ccc                                  33


<210>  14
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  CTLD3 reverse primer

<400>  14
tagcggccgc ttactgcttg cacaaggaca ttgc                                 34


<210>  15
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  CTLD6 reverse primer

<400>  15
tagcggccgc ttatttttca caaacaaacc catagccttc                           40


<210>  16
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  CTLD8 reverse primer

<400>  16
tagcggccgc tcacttactg ttaccatcaa attgagcatt caa                       43


