                         SEQUENCE LISTING

<110>  Bayer Intellectual property GmbH
       Bayer Intellectual Property GmbH
 
<120>  Fusion proteins releasing Relaxin and uses thereof

<130>  BHC 11 1 034

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Relaxin-Fxa cleavage site-hum IgG1 Fc

<400>  1

Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
1               5                   10                  15      


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25                  30          


Ser Gln Glu Asp Ala Pro Gln Thr Pro Arg Pro Val Ala Glu Ile Val 
        35                  40                  45              


Pro Ser Phe Ile Asn Lys Asp Thr Glu Thr Ile Asn Met Met Ser Glu 
    50                  55                  60                  


Phe Val Ala Asn Leu Pro Gln Glu Leu Lys Leu Thr Leu Ser Glu Met 
65                  70                  75                  80  


Gln Pro Ala Leu Pro Gln Leu Gln Gln His Val Pro Val Leu Lys Asp 
                85                  90                  95      


Ser Ser Leu Leu Phe Glu Glu Phe Lys Lys Leu Ile Arg Asn Arg Gln 
            100                 105                 110         


Ser Glu Ala Ala Asp Ser Ser Pro Ser Glu Leu Lys Tyr Leu Gly Leu 
        115                 120                 125             


Asp Thr His Ser Arg Lys Lys Arg Gln Leu Tyr Ser Ala Leu Ala Asn 
    130                 135                 140                 


Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
145                 150                 155                 160 


Ile Glu Gly Arg Met Asp Pro Lys Ala Cys Asp Lys Thr His Thr Cys 
                165                 170                 175     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            180                 185                 190         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        195                 200                 205             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    210                 215                 220                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
225                 230                 235                 240 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                245                 250                 255     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            260                 265                 270         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        275                 280                 285             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    290                 295                 300                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
305                 310                 315                 320 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                325                 330                 335     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            340                 345                 350         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        355                 360                 365             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    370                 375                 380                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395         


<210>  2
<211>  679
<212>  PRT
<213>  Homo Sapiens

<400>  2

Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu His Glu Ala 
1               5                   10                  15      


Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val Ile Pro Ser 
            20                  25                  30          


Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys 
        35                  40                  45              


Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala 
    50                  55                  60                  


Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val 
65                  70                  75                  80  


Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr 
                85                  90                  95      


Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu 
            100                 105                 110         


Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp 
        115                 120                 125             


Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys 
    130                 135                 140                 


Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro 
145                 150                 155                 160 


Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly 
                165                 170                 175     


Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe 
            180                 185                 190         


Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val Lys His Ser 
        195                 200                 205             


Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu 
    210                 215                 220                 


Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp 
225                 230                 235                 240 


Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala Arg Ser Met 
                245                 250                 255     


Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu 
            260                 265                 270         


His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro 
        275                 280                 285             


His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys 
    290                 295                 300                 


Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val 
305                 310                 315                 320 


Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr 
                325                 330                 335     


Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His His Glu Arg 
            340                 345                 350         


Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys 
        355                 360                 365             


Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly 
    370                 375                 380                 


Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly 
385                 390                 395                 400 


Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp 
                405                 410                 415     


Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Val Ala Val Val 
            420                 425                 430         


Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys 
        435                 440                 445             


Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met 
    450                 455                 460                 


Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe 
465                 470                 475                 480 


Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys 
                485                 490                 495     


Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn Asn Lys Glu 
            500                 505                 510         


Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val Glu Lys Gly 
        515                 520                 525             


Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn Thr Gly Gly 
    530                 535                 540                 


Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys Asp Tyr Glu 
545                 550                 555                 560 


Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu Tyr Ala Asn 
                565                 570                 575     


Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr Arg Lys Asp 
            580                 585                 590         


Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln His Leu Phe 
        595                 600                 605             


Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu Phe Arg Ser 
    610                 615                 620                 


Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys Leu Ala Lys 
625                 630                 635                 640 


Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu Glu Tyr Val 
                645                 650                 655     


Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser Leu Leu Glu 
            660                 665                 670         


Ala Cys Thr Phe Arg Arg Pro 
        675                 


<210>  3
<211>  585
<212>  PRT
<213>  Homo Sapiens

<400>  3

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  4
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  4

Pro Lys Ala Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  5
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  5

Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
1               5                   10                  15      


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25                  30          


Ser Gln Glu Asp Ala Pro Gln Thr Pro Arg Pro Val Ala Glu Ile Val 
        35                  40                  45              


Pro Ser Phe Ile Asn Lys Asp Thr Glu Thr Ile Asn Met Met Ser Glu 
    50                  55                  60                  


Phe Val Ala Asn Leu Pro Gln Glu Leu Lys Leu Thr Leu Ser Glu Met 
65                  70                  75                  80  


Gln Pro Ala Leu Pro Gln Leu Gln Gln His Val Pro Val Leu Lys Asp 
                85                  90                  95      


Ser Ser Leu Leu Phe Glu Glu Phe Lys Lys Leu Ile Arg Asn Arg Gln 
            100                 105                 110         


Ser Glu Ala Ala Asp Ser Ser Pro Ser Glu Leu Lys Tyr Leu Gly Leu 
        115                 120                 125             


Asp Thr His Ser Arg Lys Lys Arg Gln Leu Tyr Ser Ala Leu Ala Asn 
    130                 135                 140                 


Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
145                 150                 155                 160 


<210>  6
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  6

Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      


Lys Arg Ser Leu Ala Arg Phe Cys 
            20                  


<210>  7
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  7

Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
1               5                   10                  15      


<210>  8
<211>  28
<212>  PRT
<213>  Homo Sapiens

<400>  8

Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
1               5                   10                  15      


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
            20                  25              


<210>  9
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  9

Arg Ala Ala Pro Tyr Gly Val Arg Leu Cys Gly Arg Glu Phe Ile Arg 
1               5                   10                  15      


Ala Val Ile Phe Thr Cys Gly Gly Ser Arg Trp Arg Arg Ser Asp Ile 
            20                  25                  30          


Leu Ala His Glu Ala Met Gly Asp Thr Phe Pro Asp Ala Asp Ala Asp 
        35                  40                  45              


Glu Asp Ser Leu Ala Gly Glu Leu Asp Glu Ala Met Gly Ser Ser Glu 
    50                  55                  60                  


Trp Leu Ala Leu Thr Lys Ser Pro Gln Ala Phe Tyr Arg Gly Arg Pro 
65                  70                  75                  80  


Ser Trp Gln Gly Thr Pro Gly Val Leu Arg Gly Ser Arg Asp Val Leu 
                85                  90                  95      


Ala Gly Leu Ser Ser Ser Cys Cys Lys Trp Gly Cys Ser Lys Ser Glu 
            100                 105                 110         


Ile Ser Ser Leu Cys 
        115         


<210>  10
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  10

Asp Val Leu Ala Gly Leu Ser Ser Ser Cys Cys Lys Trp Gly Cys Ser 
1               5                   10                  15      


Lys Ser Glu Ile Ser Ser Leu Cys 
            20                  


<210>  11
<211>  27
<212>  PRT
<213>  Homo Sapiens

<400>  11

Arg Ala Ala Pro Tyr Gly Val Arg Leu Cys Gly Arg Glu Phe Ile Arg 
1               5                   10                  15      


Ala Val Ile Phe Thr Cys Gly Gly Ser Arg Trp 
            20                  25          


<210>  12
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  12

Cys Cys Lys Trp Gly Cys Ser Lys Ser Glu Ile Ser Ser Leu Cys 
1               5                   10                  15  


<210>  13
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Relaxin - MMP9 cleavage site - humFc IgG1

<400>  13

Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
1               5                   10                  15      


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25                  30          


Ser Gln Glu Asp Ala Pro Gln Thr Pro Arg Pro Val Ala Glu Ile Val 
        35                  40                  45              


Pro Ser Phe Ile Asn Lys Asp Thr Glu Thr Ile Asn Met Met Ser Glu 
    50                  55                  60                  


Phe Val Ala Asn Leu Pro Gln Glu Leu Lys Leu Thr Leu Ser Glu Met 
65                  70                  75                  80  


Gln Pro Ala Leu Pro Gln Leu Gln Gln His Val Pro Val Leu Lys Asp 
                85                  90                  95      


Ser Ser Leu Leu Phe Glu Glu Phe Lys Lys Leu Ile Arg Asn Arg Gln 
            100                 105                 110         


Ser Glu Ala Ala Asp Ser Ser Pro Ser Glu Leu Lys Tyr Leu Gly Leu 
        115                 120                 125             


Asp Thr His Ser Arg Lys Lys Arg Gln Leu Tyr Ser Ala Leu Ala Asn 
    130                 135                 140                 


Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
145                 150                 155                 160 


Arg Ala Lys Arg Phe Ala Ser Leu Pro Lys Ala Cys Asp Lys Thr His 
                165                 170                 175     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            180                 185                 190         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        195                 200                 205             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    210                 215                 220                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
225                 230                 235                 240 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                245                 250                 255     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            260                 265                 270         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        275                 280                 285             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    290                 295                 300                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
305                 310                 315                 320 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                325                 330                 335     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            340                 345                 350         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        355                 360                 365             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    370                 375                 380                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395                 


<210>  14
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Relaxin - Chymase cleavage site- humFc IgG1

<400>  14

Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
1               5                   10                  15      


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25                  30          


Ser Gln Glu Asp Ala Pro Gln Thr Pro Arg Pro Val Ala Glu Ile Val 
        35                  40                  45              


Pro Ser Phe Ile Asn Lys Asp Thr Glu Thr Ile Asn Met Met Ser Glu 
    50                  55                  60                  


Phe Val Ala Asn Leu Pro Gln Glu Leu Lys Leu Thr Leu Ser Glu Met 
65                  70                  75                  80  


Gln Pro Ala Leu Pro Gln Leu Gln Gln His Val Pro Val Leu Lys Asp 
                85                  90                  95      


Ser Ser Leu Leu Phe Glu Glu Phe Lys Lys Leu Ile Arg Asn Arg Gln 
            100                 105                 110         


Ser Glu Ala Ala Asp Ser Ser Pro Ser Glu Leu Lys Tyr Leu Gly Leu 
        115                 120                 125             


Asp Thr His Ser Arg Lys Lys Arg Gln Leu Tyr Ser Ala Leu Ala Asn 
    130                 135                 140                 


Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
145                 150                 155                 160 


Arg Val Gly Phe Tyr Glu Ser Asp Pro Lys Ala Cys Asp Lys Thr His 
                165                 170                 175     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            180                 185                 190         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        195                 200                 205             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    210                 215                 220                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
225                 230                 235                 240 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                245                 250                 255     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            260                 265                 270         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        275                 280                 285             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    290                 295                 300                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
305                 310                 315                 320 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                325                 330                 335     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            340                 345                 350         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        355                 360                 365             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    370                 375                 380                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395                 


<210>  15
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Relaxin - Trypsin cleavage site- humFc IgG1

<400>  15

Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
1               5                   10                  15      


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25                  30          


Ser Gln Glu Asp Ala Pro Gln Thr Pro Arg Pro Val Ala Glu Ile Val 
        35                  40                  45              


Pro Ser Phe Ile Asn Lys Asp Thr Glu Thr Ile Asn Met Met Ser Glu 
    50                  55                  60                  


Phe Val Ala Asn Leu Pro Gln Glu Leu Lys Leu Thr Leu Ser Glu Met 
65                  70                  75                  80  


Gln Pro Ala Leu Pro Gln Leu Gln Gln His Val Pro Val Leu Lys Asp 
                85                  90                  95      


Ser Ser Leu Leu Phe Glu Glu Phe Lys Lys Leu Ile Arg Asn Arg Gln 
            100                 105                 110         


Ser Glu Ala Ala Asp Ser Ser Pro Ser Glu Leu Lys Tyr Leu Gly Leu 
        115                 120                 125             


Asp Thr His Ser Arg Lys Lys Arg Gln Leu Tyr Ser Ala Leu Ala Asn 
    130                 135                 140                 


Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
145                 150                 155                 160 


Ile Asn Ala Arg Val Ser Thr Ile Pro Lys Ala Cys Asp Lys Thr His 
                165                 170                 175     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            180                 185                 190         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        195                 200                 205             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    210                 215                 220                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
225                 230                 235                 240 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                245                 250                 255     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            260                 265                 270         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        275                 280                 285             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    290                 295                 300                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
305                 310                 315                 320 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                325                 330                 335     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            340                 345                 350         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        355                 360                 365             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    370                 375                 380                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395                 


<210>  16
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Relaxin - Elastase cleavage site- humFc IgG1

<400>  16

Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
1               5                   10                  15      


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25                  30          


Ser Gln Glu Asp Ala Pro Gln Thr Pro Arg Pro Val Ala Glu Ile Val 
        35                  40                  45              


Pro Ser Phe Ile Asn Lys Asp Thr Glu Thr Ile Asn Met Met Ser Glu 
    50                  55                  60                  


Phe Val Ala Asn Leu Pro Gln Glu Leu Lys Leu Thr Leu Ser Glu Met 
65                  70                  75                  80  


Gln Pro Ala Leu Pro Gln Leu Gln Gln His Val Pro Val Leu Lys Asp 
                85                  90                  95      


Ser Ser Leu Leu Phe Glu Glu Phe Lys Lys Leu Ile Arg Asn Arg Gln 
            100                 105                 110         


Ser Glu Ala Ala Asp Ser Ser Pro Ser Glu Leu Lys Tyr Leu Gly Leu 
        115                 120                 125             


Asp Thr His Ser Arg Lys Lys Arg Gln Leu Tyr Ser Ala Leu Ala Asn 
    130                 135                 140                 


Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
145                 150                 155                 160 


Gly Leu Arg Val Gly Phe Tyr Glu Pro Lys Ala Cys Asp Lys Thr His 
                165                 170                 175     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            180                 185                 190         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        195                 200                 205             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    210                 215                 220                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
225                 230                 235                 240 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                245                 250                 255     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            260                 265                 270         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        275                 280                 285             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    290                 295                 300                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
305                 310                 315                 320 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                325                 330                 335     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            340                 345                 350         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        355                 360                 365             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    370                 375                 380                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395                 


<210>  17
<211>  1191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Relaxin - Fxa cleavage site- hum IgG1 Fc

<400>  17
agctggatgg aagaagtgat taaactgtgc ggccgcgaac tggtgcgcgc gcagattgcg       60

atttgcggca tgagcacctg gagcaaacgc agcctgagcc aggaagatgc gccgcagacc      120

ccgcgcccgg tggcggaaat tgtgccgagc tttattaaca aagataccga aaccattaac      180

atgatgagcg aatttgtggc gaacctgccg caggaactga aactgaccct gagcgaaatg      240

cagccggcgc tgccgcagct gcagcagcat gtgccggtgc tgaaagatag cagcctgctg      300

tttgaagaat ttaaaaaact gattcgcaac cgccagagcg aagcggcgga tagcagcccg      360

agcgaactga aatatctggg cctggatacc catagccgca aaaaacgcca gctgtatagc      420

gcgctggcga acaaatgctg ccatgtgggc tgcaccaaac gcagcctggc gcgcttttgc      480

attgaaggcc gcatggatcc gaaagcgtgc gataaaaccc atacctgccc gccgtgcccg      540

gcgccggaac tgctgggcgg cccgagcgtg tttctgtttc cgccgaaacc gaaagatacc      600

ctgatgatta gccgcacccc ggaagtgacc tgcgtggtgg tggatgtgag ccatgaagat      660

ccggaagtga aatttaactg gtatgtggat ggcgtggaag tgcataacgc gaaaaccaaa      720

ccgcgcgaag aacagtataa cagcacctat cgcgtggtga gcgtgctgac cgtgctgcat      780

caggattggc tgaacggcaa agaatataaa tgcaaagtga gcaacaaagc gctgccggcg      840

ccgattgaaa aaaccattag caaagcgaaa ggccagccgc gcgaaccgca ggtgtatacc      900

ctgccgccga gccgcgatga actgaccaaa aaccaggtga gcctgacctg cctggtgaaa      960

ggcttttatc cgagcgatat tgcggtggaa tgggaaagca acggccagcc ggaaaacaac     1020

tataaaacca ccccgccggt gctggatagc gatggcagct tttttctgta tagcaaactg     1080

accgtggata aaagccgctg gcagcagggc aacgtgttta gctgcagcgt gatgcatgaa     1140

gcgctgcata accattatac ccagaaaagc ctgagcctga gcccgggcaa a              1191


<210>  18
<211>  2037
<212>  DNA
<213>  Homo Sapiens

<400>  18
gtgccggata aaaccgtgcg ctggtgcgcg gtgagcgaac atgaagcgac caaatgccag       60

agctttcgcg atcatatgaa aagcgtgatt ccgagcgatg gcccgagcgt ggcgtgcgtg      120

aaaaaagcga gctatctgga ttgcattcgc gcgattgcgg cgaacgaagc ggatgcggtg      180

accctggatg cgggcctggt gtatgatgcg tatctggcgc cgaacaacct gaaaccggtg      240

gtggcggaat tttatggcag caaagaagat ccgcagacct tttattatgc ggtggcggtg      300

gtgaaaaaag atagcggctt tcagatgaac cagctgcgcg gcaaaaaaag ctgccatacc      360

ggcctgggcc gcagcgcggg ctggaacatt ccgattggcc tgctgtattg cgatctgccg      420

gaaccgcgca aaccgctgga aaaagcggtg gcgaactttt ttagcggcag ctgcgcgccg      480

tgcgcggatg gcaccgattt tccgcagctg tgccagctgt gcccgggctg cggctgcagc      540

accctgaacc agtattttgg ctatagcggc gcgtttaaat gcctgaaaga tggcgcgggc      600

gatgtggcgt ttgtgaaaca tagcaccatt tttgaaaacc tggcgaacaa agcggatcgc      660

gatcagtatg aactgctgtg cctggataac acccgcaaac cggtggatga atataaagat      720

tgccatctgg cgcaggtgcc gagccatacc gtggtggcgc gcagcatggg cggcaaagaa      780

gatctgattt gggaactgct gaaccaggcg caggaacatt ttggcaaaga taaaagcaaa      840

gaatttcagc tgtttagcag cccgcatggc aaagatctgc tgtttaaaga tagcgcgcat      900

ggctttctga aagtgccgcc gcgcatggat gcgaaaatgt atctgggcta tgaatatgtg      960

accgcgattc gcaacctgcg cgaaggcacc tgcccggaag cgccgaccga tgaatgcaaa     1020

ccggtgaaat ggtgcgcgct gagccatcat gaacgcctga aatgcgatga atggagcgtg     1080

aacagcgtgg gcaaaattga atgcgtgagc gcggaaacca ccgaagattg cattgcgaaa     1140

attatgaacg gcgaagcgga tgcgatgagc ctggatggcg gctttgtgta tattgcgggc     1200

aaatgcggcc tggtgccggt gctggcggaa aactataaca aaagcgataa ctgcgaagat     1260

accccggaag cgggctattt tgcggtggcg gtggtgaaaa aaagcgcgag cgatctgacc     1320

tgggataacc tgaaaggcaa aaaaagctgc cataccgcgg tgggccgcac cgcgggctgg     1380

aacattccga tgggcctgct gtataacaaa attaaccatt gccgctttga tgaatttttt     1440

agcgaaggct gcgcgccggg cagcaaaaaa gatagcagcc tgtgcaaact gtgcatgggc     1500

agcggcctga acctgtgcga accgaacaac aaagaaggct attatggcta taccggcgcg     1560

tttcgctgcc tggtggaaaa aggcgatgtg gcgtttgtga aacatcagac cgtgccgcag     1620

aacaccggcg gcaaaaaccc ggatccgtgg gcgaaaaacc tgaacgaaaa agattatgaa     1680

ctgctgtgcc tggatggcac ccgcaaaccg gtggaagaat atgcgaactg ccatctggcg     1740

cgcgcgccga accatgcggt ggtgacccgc aaagataaag aagcgtgcgt gcataaaatt     1800

ctgcgccagc agcagcatct gtttggcagc aacgtgaccg attgcagcgg caacttttgc     1860

ctgtttcgca gcgaaaccaa agatctgctg tttcgcgatg ataccgtgtg cctggcgaaa     1920

ctgcatgatc gcaacaccta tgaaaaatat ctgggcgaag aatatgtgaa agcggtgggc     1980

aacctgcgca aatgcagcac cagcagcctg ctggaagcgt gcacctttcg ccgcccg        2037


<210>  19
<211>  1755
<212>  DNA
<213>  Homo Sapiens

<400>  19
gatgcgcata aaagcgaagt ggcgcatcgc tttaaagatc tgggcgaaga aaactttaaa       60

gcgctggtgc tgattgcgtt tgcgcagtat ctgcagcagt gcccgtttga agatcatgtg      120

aaactggtga acgaagtgac cgaatttgcg aaaacctgcg tggcggatga aagcgcggaa      180

aactgcgata aaagcctgca taccctgttt ggcgataaac tgtgcaccgt ggcgaccctg      240

cgcgaaacct atggcgaaat ggcggattgc tgcgcgaaac aggaaccgga acgcaacgaa      300

tgctttctgc agcataaaga tgataacccg aacctgccgc gcctggtgcg cccggaagtg      360

gatgtgatgt gcaccgcgtt tcatgataac gaagaaacct ttctgaaaaa atatctgtat      420

gaaattgcgc gccgccatcc gtatttttat gcgccggaac tgctgttttt tgcgaaacgc      480

tataaagcgg cgtttaccga atgctgccag gcggcggata aagcggcgtg cctgctgccg      540

aaactggatg aactgcgcga tgaaggcaaa gcgagcagcg cgaaacagcg cctgaaatgc      600

gcgagcctgc agaaatttgg cgaacgcgcg tttaaagcgt gggcggtggc gcgcctgagc      660

cagcgctttc cgaaagcgga atttgcggaa gtgagcaaac tggtgaccga tctgaccaaa      720

gtgcataccg aatgctgcca tggcgatctg ctggaatgcg cggatgatcg cgcggatctg      780

gcgaaatata tttgcgaaaa ccaggatagc attagcagca aactgaaaga atgctgcgaa      840

aaaccgctgc tggaaaaaag ccattgcatt gcggaagtgg aaaacgatga aatgccggcg      900

gatctgccga gcctggcggc ggattttgtg gaaagcaaag atgtgtgcaa aaactatgcg      960

gaagcgaaag atgtgtttct gggcatgttt ctgtatgaat atgcgcgccg ccatccggat     1020

tatagcgtgg tgctgctgct gcgcctggcg aaaacctatg aaaccaccct ggaaaaatgc     1080

tgcgcggcgg cggatccgca tgaatgctat gcgaaagtgt ttgatgaatt taaaccgctg     1140

gtggaagaac cgcagaacct gattaaacag aactgcgaac tgtttgaaca gctgggcgaa     1200

tataaatttc agaacgcgct gctggtgcgc tataccaaaa aagtgccgca ggtgagcacc     1260

ccgaccctgg tggaagtgag ccgcaacctg ggcaaagtgg gcagcaaatg ctgcaaacat     1320

ccggaagcga aacgcatgcc gtgcgcggaa gattatctga gcgtggtgct gaaccagctg     1380

tgcgtgctgc atgaaaaaac cccggtgagc gatcgcgtga ccaaatgctg caccgaaagc     1440

ctggtgaacc gccgcccgtg ctttagcgcg ctggaagtgg atgaaaccta tgtgccgaaa     1500

gaatttaacg cggaaacctt tacctttcat gcggatattt gcaccctgag cgaaaaagaa     1560

cgccagatta aaaaacagac cgcgctggtg gaactggtga aacataaacc gaaagcgacc     1620

aaagaacagc tgaaagcggt gatggatgat tttgcggcgt ttgtggaaaa atgctgcaaa     1680

gcggatgata aagaaacctg ctttgcggaa gaaggcaaaa aactggtggc ggcgagccag     1740

gcggcgctgg gcctg                                                      1755


<210>  20
<211>  693
<212>  DNA
<213>  Homo Sapiens

<400>  20
ccgaaagcgt gcgataaaac ccatacctgc ccgccgtgcc cggcgccgga actgctgggc       60

ggcccgagcg tgtttctgtt tccgccgaaa ccgaaagata ccctgatgat tagccgcacc      120

ccggaagtga cctgcgtggt ggtggatgtg agccatgaag atccggaagt gaaatttaac      180

tggtatgtgg atggcgtgga agtgcataac gcgaaaacca aaccgcgcga agaacagtat      240

aacagcacct atcgcgtggt gagcgtgctg accgtgctgc atcaggattg gctgaacggc      300

aaagaatata aatgcaaagt gagcaacaaa gcgctgccgg cgccgattga aaaaaccatt      360

agcaaagcga aaggccagcc gcgcgaaccg caggtgtata ccctgccgcc gagccgcgat      420

gaactgacca aaaaccaggt gagcctgacc tgcctggtga aaggctttta tccgagcgat      480

attgcggtgg aatgggaaag caacggccag ccggaaaaca actataaaac caccccgccg      540

gtgctggata gcgatggcag cttttttctg tatagcaaac tgaccgtgga taaaagccgc      600

tggcagcagg gcaacgtgtt tagctgcagc gtgatgcatg aagcgctgca taaccattat      660

acccagaaaa gcctgagcct gagcccgggc aaa                                   693


<210>  21
<211>  480
<212>  DNA
<213>  Homo Sapiens

<400>  21
agctggatgg aagaagtgat taaactgtgc ggccgcgaac tggtgcgcgc gcagattgcg       60

atttgcggca tgagcacctg gagcaaacgc agcctgagcc aggaagatgc gccgcagacc      120

ccgcgcccgg tggcggaaat tgtgccgagc tttattaaca aagataccga aaccattaac      180

atgatgagcg aatttgtggc gaacctgccg caggaactga aactgaccct gagcgaaatg      240

cagccggcgc tgccgcagct gcagcagcat gtgccggtgc tgaaagatag cagcctgctg      300

tttgaagaat ttaaaaaact gattcgcaac cgccagagcg aagcggcgga tagcagcccg      360

agcgaactga aatatctggg cctggatacc catagccgca aaaaacgcca gctgtatagc      420

gcgctggcga acaaatgctg ccatgtgggc tgcaccaaac gcagcctggc gcgcttttgc      480


<210>  22
<211>  72
<212>  DNA
<213>  Homo Sapiens

<400>  22
cagctgtata gcgcgctggc gaacaaatgc tgccatgtgg gctgcaccaa acgcagcctg       60

gcgcgctttt gc                                                           72


<210>  23
<211>  48
<212>  DNA
<213>  Homo Sapiens

<400>  23
aaatgctgcc atgtgggctg caccaaacgc agcctggcgc gcttttgc                    48


<210>  24
<211>  84
<212>  DNA
<213>  Homo Sapiens

<400>  24
agctggatgg aagaagtgat taaactgtgc ggccgcgaac tggtgcgcgc gcagattgcg       60

atttgcggca tgagcacctg gagc                                              84


<210>  25
<211>  351
<212>  DNA
<213>  Homo Sapiens

<400>  25
cgcgcggcgc cgtatggcgt gcgcctgtgc ggccgcgaat ttattcgcgc ggtgattttt       60

acctgcggcg gcagccgctg gcgccgcagc gatattctgg cgcatgaagc gatgggcgat      120

acctttccgg atgcggatgc ggatgaagat agcctggcgg gcgaactgga tgaagcgatg      180

ggcagcagcg aatggctggc gctgaccaaa agcccgcagg cgttttatcg cggccgcccg      240

agctggcagg gcaccccggg cgtgctgcgc ggcagccgcg atgtgctggc gggcctgagc      300

agcagctgct gcaaatgggg ctgcagcaaa agcgaaatta gcagcctgtg c               351


<210>  26
<211>  72
<212>  DNA
<213>  Homo Sapiens

<400>  26
gatgtgctgg cgggcctgag cagcagctgc tgcaaatggg gctgcagcaa aagcgaaatt       60

agcagcctgt gc                                                           72


<210>  27
<211>  81
<212>  DNA
<213>  Homo Sapiens

<400>  27
cgcgcggcgc cgtatggcgt gcgcctgtgc ggccgcgaat ttattcgcgc ggtgattttt       60

acctgcggcg gcagccgctg g                                                 81


<210>  28
<211>  45
<212>  DNA
<213>  Homo Sapiens

<400>  28
tgctgcaaat ggggctgcag caaaagcgaa attagcagcc tgtgc                       45


<210>  29
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Relaxin - MMP9 cleavage site- humFc IgG1

<400>  29
agctggatgg aagaagtgat taaactgtgc ggccgcgaac tggtgcgcgc gcagattgcg       60

atttgcggca tgagcacctg gagcaaacgc agcctgagcc aggaagatgc gccgcagacc      120

ccgcgcccgg tggcggaaat tgtgccgagc tttattaaca aagataccga aaccattaac      180

atgatgagcg aatttgtggc gaacctgccg caggaactga aactgaccct gagcgaaatg      240

cagccggcgc tgccgcagct gcagcagcat gtgccggtgc tgaaagatag cagcctgctg      300

tttgaagaat ttaaaaaact gattcgcaac cgccagagcg aagcggcgga tagcagcccg      360

agcgaactga aatatctggg cctggatacc catagccgca aaaaacgcca gctgtatagc      420

gcgctggcga acaaatgctg ccatgtgggc tgcaccaaac gcagcctggc gcgcttttgc      480

cgcgcgaaac gctttgcgag cctgccgaaa gcgtgcgata aaacccatac ctgcccgccg      540

tgcccggcgc cggaactgct gggcggcccg agcgtgtttc tgtttccgcc gaaaccgaaa      600

gataccctga tgattagccg caccccggaa gtgacctgcg tggtggtgga tgtgagccat      660

gaagatccgg aagtgaaatt taactggtat gtggatggcg tggaagtgca taacgcgaaa      720

accaaaccgc gcgaagaaca gtataacagc acctatcgcg tggtgagcgt gctgaccgtg      780

ctgcatcagg attggctgaa cggcaaagaa tataaatgca aagtgagcaa caaagcgctg      840

ccggcgccga ttgaaaaaac cattagcaaa gcgaaaggcc agccgcgcga accgcaggtg      900

tataccctgc cgccgagccg cgatgaactg accaaaaacc aggtgagcct gacctgcctg      960

gtgaaaggct tttatccgag cgatattgcg gtggaatggg aaagcaacgg ccagccggaa     1020

aacaactata aaaccacccc gccggtgctg gatagcgatg gcagcttttt tctgtatagc     1080

aaactgaccg tggataaaag ccgctggcag cagggcaacg tgtttagctg cagcgtgatg     1140

catgaagcgc tgcataacca ttatacccag aaaagcctga gcctgagccc gggcaaa        1197


<210>  30
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Relaxin - Chymase cleavage site- humFc IgG1

<400>  30
agctggatgg aagaagtgat taaactgtgc ggccgcgaac tggtgcgcgc gcagattgcg       60

atttgcggca tgagcacctg gagcaaacgc agcctgagcc aggaagatgc gccgcagacc      120

ccgcgcccgg tggcggaaat tgtgccgagc tttattaaca aagataccga aaccattaac      180

atgatgagcg aatttgtggc gaacctgccg caggaactga aactgaccct gagcgaaatg      240

cagccggcgc tgccgcagct gcagcagcat gtgccggtgc tgaaagatag cagcctgctg      300

tttgaagaat ttaaaaaact gattcgcaac cgccagagcg aagcggcgga tagcagcccg      360

agcgaactga aatatctggg cctggatacc catagccgca aaaaacgcca gctgtatagc      420

gcgctggcga acaaatgctg ccatgtgggc tgcaccaaac gcagcctggc gcgcttttgc      480

cgcgtgggct tttatgaaag cgatccgaaa gcgtgcgata aaacccatac ctgcccgccg      540

tgcccggcgc cggaactgct gggcggcccg agcgtgtttc tgtttccgcc gaaaccgaaa      600

gataccctga tgattagccg caccccggaa gtgacctgcg tggtggtgga tgtgagccat      660

gaagatccgg aagtgaaatt taactggtat gtggatggcg tggaagtgca taacgcgaaa      720

accaaaccgc gcgaagaaca gtataacagc acctatcgcg tggtgagcgt gctgaccgtg      780

ctgcatcagg attggctgaa cggcaaagaa tataaatgca aagtgagcaa caaagcgctg      840

ccggcgccga ttgaaaaaac cattagcaaa gcgaaaggcc agccgcgcga accgcaggtg      900

tataccctgc cgccgagccg cgatgaactg accaaaaacc aggtgagcct gacctgcctg      960

gtgaaaggct tttatccgag cgatattgcg gtggaatggg aaagcaacgg ccagccggaa     1020

aacaactata aaaccacccc gccggtgctg gatagcgatg gcagcttttt tctgtatagc     1080

aaactgaccg tggataaaag ccgctggcag cagggcaacg tgtttagctg cagcgtgatg     1140

catgaagcgc tgcataacca ttatacccag aaaagcctga gcctgagccc gggcaaa        1197


<210>  31
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Relaxin - Trypsin cleavage site- humFc IgG1

<400>  31
agctggatgg aagaagtgat taaactgtgc ggccgcgaac tggtgcgcgc gcagattgcg       60

atttgcggca tgagcacctg gagcaaacgc agcctgagcc aggaagatgc gccgcagacc      120

ccgcgcccgg tggcggaaat tgtgccgagc tttattaaca aagataccga aaccattaac      180

atgatgagcg aatttgtggc gaacctgccg caggaactga aactgaccct gagcgaaatg      240

cagccggcgc tgccgcagct gcagcagcat gtgccggtgc tgaaagatag cagcctgctg      300

tttgaagaat ttaaaaaact gattcgcaac cgccagagcg aagcggcgga tagcagcccg      360

agcgaactga aatatctggg cctggatacc catagccgca aaaaacgcca gctgtatagc      420

gcgctggcga acaaatgctg ccatgtgggc tgcaccaaac gcagcctggc gcgcttttgc      480

attaacgcgc gcgtgagcac cattccgaaa gcgtgcgata aaacccatac ctgcccgccg      540

tgcccggcgc cggaactgct gggcggcccg agcgtgtttc tgtttccgcc gaaaccgaaa      600

gataccctga tgattagccg caccccggaa gtgacctgcg tggtggtgga tgtgagccat      660

gaagatccgg aagtgaaatt taactggtat gtggatggcg tggaagtgca taacgcgaaa      720

accaaaccgc gcgaagaaca gtataacagc acctatcgcg tggtgagcgt gctgaccgtg      780

ctgcatcagg attggctgaa cggcaaagaa tataaatgca aagtgagcaa caaagcgctg      840

ccggcgccga ttgaaaaaac cattagcaaa gcgaaaggcc agccgcgcga accgcaggtg      900

tataccctgc cgccgagccg cgatgaactg accaaaaacc aggtgagcct gacctgcctg      960

gtgaaaggct tttatccgag cgatattgcg gtggaatggg aaagcaacgg ccagccggaa     1020

aacaactata aaaccacccc gccggtgctg gatagcgatg gcagcttttt tctgtatagc     1080

aaactgaccg tggataaaag ccgctggcag cagggcaacg tgtttagctg cagcgtgatg     1140

catgaagcgc tgcataacca ttatacccag aaaagcctga gcctgagccc gggcaaa        1197


<210>  32
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Relaxin - Elastase cleavage site- humFc IgG1

<400>  32
agctggatgg aagaagtgat taaactgtgc ggccgcgaac tggtgcgcgc gcagattgcg       60

atttgcggca tgagcacctg gagcaaacgc agcctgagcc aggaagatgc gccgcagacc      120

ccgcgcccgg tggcggaaat tgtgccgagc tttattaaca aagataccga aaccattaac      180

atgatgagcg aatttgtggc gaacctgccg caggaactga aactgaccct gagcgaaatg      240

cagccggcgc tgccgcagct gcagcagcat gtgccggtgc tgaaagatag cagcctgctg      300

tttgaagaat ttaaaaaact gattcgcaac cgccagagcg aagcggcgga tagcagcccg      360

agcgaactga aatatctggg cctggatacc catagccgca aaaaacgcca gctgtatagc      420

gcgctggcga acaaatgctg ccatgtgggc tgcaccaaac gcagcctggc gcgcttttgc      480

ggcctgcgcg tgggctttta tgaaccgaaa gcgtgcgata aaacccatac ctgcccgccg      540

tgcccggcgc cggaactgct gggcggcccg agcgtgtttc tgtttccgcc gaaaccgaaa      600

gataccctga tgattagccg caccccggaa gtgacctgcg tggtggtgga tgtgagccat      660

gaagatccgg aagtgaaatt taactggtat gtggatggcg tggaagtgca taacgcgaaa      720

accaaaccgc gcgaagaaca gtataacagc acctatcgcg tggtgagcgt gctgaccgtg      780

ctgcatcagg attggctgaa cggcaaagaa tataaatgca aagtgagcaa caaagcgctg      840

ccggcgccga ttgaaaaaac cattagcaaa gcgaaaggcc agccgcgcga accgcaggtg      900

tataccctgc cgccgagccg cgatgaactg accaaaaacc aggtgagcct gacctgcctg      960

gtgaaaggct tttatccgag cgatattgcg gtggaatggg aaagcaacgg ccagccggaa     1020

aacaactata aaaccacccc gccggtgctg gatagcgatg gcagcttttt tctgtatagc     1080

aaactgaccg tggataaaag ccgctggcag cagggcaacg tgtttagctg cagcgtgatg     1140

catgaagcgc tgcataacca ttatacccag aaaagcctga gcctgagccc gggcaaa        1197


