                                SEQUENCE LISTING

<110> Karsunky, Holger
      Jiang, Ying-Ping
      Cellerant Therapeutics, Inc.

<120> Antibodies That Specifically Bind to TIM3

<130> 92950-845267

<140> WO PCT/US12/45102   
<141> 2012-06-29  

<150> US 61/504,062       
<151> 2011-07-01  

<150> US 61/660,530       
<151> 2012-06-15  

<160> 122

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      heavy chain

<400> 1
gaggtgaagc ttctcgagtc tggaggtggc ctggtgcagc ctggaggatc cctgaaactc 60
tcctgtgcag cctcaggatt cgattttagt agatactgga tgagttgggt ccggcaggct 120
ccagggaaag ggctagaatg gattggagaa attaatccag atagcagtac gataaactat 180
acgccatctc taaaggataa attcatcatc tccagagaca acgccaaaaa tacgctgttc 240
ctgcaaatga gcaaagtgag atctgaggac acagcccttt attactgtgc aagaccgagc 300
tatgatggtt actacgggta tgctatggac tactggggtc aaggaacctc agtcaccgtc 360
tcctca                                                            366

<210> 2
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      heavy chain

<400> 2
Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu
    50                  55                  60                  
Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Ala Arg Pro Ser Tyr Asp Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120         


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      heavy chain CDRH1

<400> 3
Gly Phe Asp Phe Ser Arg Tyr Trp
 1               5              


<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      heavy chain CDRH2

<400> 4
Ile Asn Pro Asp Ser Ser Thr Ile
 1               5              


<210> 5
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      heavy chain CDRH3

<400> 5
Ala Arg Pro Ser Tyr Asp Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr
 1               5                  10                  15  


<210> 6
<211> 335
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      light chain

<400> 6
gacattgtac tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 60
atatcctgca gagccagtga aagtgttgat agttatggca agagttttat gcactggtac 120
cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct 180
gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat 240
cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaagtaatga ggatccgtac 300
acgttcggag gggggaccaa gctggaaata aaacg                            335

<210> 7
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      light chain

<400> 7
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr
            20                  25                  30          
Gly Lys Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn
65                  70                  75                  80  
Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         


<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      light chain CDRL1

<400> 8
Glu Ser Val Asp Ser Tyr Gly Lys Ser Phe
 1               5                  10  


<210> 9
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      light chain CDRL2

<400> 9
Arg Ala Ser
 1          


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 1.7E10
      light chain CDRL3

<400> 10
Gln Gln Ser Asn Glu Asp Pro Tyr Thr
 1               5                  


<210> 11
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      heavy chain

<400> 11
gaggtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaagctc 60
tcctgtgcag cctctggatt cattttcagt ggctatggca tgtcttgggt tcgccagact 120
ccagacaaga ggctggagtt ggtcgcaatc attaatagca atggtggtag tgttgattat 180
ccagacagtg tgaagggccg agtcaccatc tccagagaca atgccaagaa caccctgtac 240
ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagaatctac 300
tatagatgta tggactactg gggtcaagga acctcagtca ccgtctcctc a          351

<210> 12
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      heavy chain

<400> 12
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Gly Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val
        35                  40                  45              
Ala Ile Ile Asn Ser Asn Gly Gly Ser Val Asp Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ile Tyr Tyr Arg Cys Met Asp Tyr Trp Gly Gln Gly Thr Ser
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      heavy chain CDRH1

<400> 13
Gly Phe Ile Phe Ser Gly Tyr Gly
 1               5              


<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      heavy chain CDRH2

<400> 14
Ile Asn Ser Asn Gly Gly Ser Val
 1               5              


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      heavy chain CDRH3

<400> 15
Ala Arg Ile Tyr Tyr Arg Cys Met Asp Tyr
 1               5                  10  


<210> 16
<211> 338
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      light chain

<400> 16
aacattatga tgacacagtc gccatcatct ctggctgtgt ctgcaggaga aaaggtcact 60
atgagttgta agtccagtca aagtctttta tacagttcaa atcagaagaa ctacttggcc 120
tggtaccagc aaaaaccagg acagtctcct aaattgctga tctactgggc ttccgctagg 180
gaatctggtg tccctgatcg cttcacaggc ggtggatctg ggacagattt tactcttacc 240
atcagcagtg tacaagctga agacctggca gtttattact gtcatcaata cctctcctcg 300
tacacgttcg gaggggggac caagctggag ataaaacg                         338

<210> 17
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      light chain

<400> 17
Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln
                85                  90                  95      
Tyr Leu Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    

<210> 18
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      light chain CDRL1

<400> 18
Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr
 1               5                  10          


<210> 19
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      light chain CDRL2

<400> 19
Trp Ala Ser
 1          


<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 7.10F6
      light chain CDRL3

<400> 20
His Gln Tyr Leu Ser Ser Tyr Thr
 1               5              


<210> 21
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      heavy chain

<400> 21
cagatccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata 60
tcctacaagg cttctggcta caccttcact gactactata taaactgggt gaagcagaag 120
cctggacagg gacttgagtg gattggatgg atttatcctg gaagcggtat tactaagtac 180
aatgagaagt tcaagggcaa ggccacattg actgtagact catcctccag cacagcctac 240
atgcagctca gcagcctgac atctgaggac actgctgtct atttctgtgc gatatatggt 300
tacgacgggg gatatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca 360


<210> 22
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      heavy chain

<400> 22
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Tyr Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Asn Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Ser Gly Ile Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Ser Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Ile Tyr Gly Tyr Asp Gly Gly Tyr Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      heavy chain CDRH1

<400> 23
Gly Tyr Thr Phe Thr Asp Tyr Tyr
 1               5              


<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      heavy chain CDRH2

<400> 24
Ile Tyr Pro Gly Ser Gly Ile Thr
 1               5              


<210> 25
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      heavy chain CDRH3

<400> 25
Ala Ile Tyr Gly Tyr Asp Gly Gly Tyr Ala Met Asp Tyr
 1               5                  10              


<210> 26
<211> 326
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      light chain

<400> 26
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctcctgggga gaaggtcacc 60
ttgacctgca gtgccagctc aagtgtaagt tccagctact tgtactggta tcagcagaag 120
ccaggatcct cccccaaact ctggatttat agcacatcca acctggcttc tggagtccct 180
gctcgcttca gtggcggtgg gtctgggacc tcttactctc tcacaatcag cagcatggag 240
gctgaagatg ctgcctctta tttctgccat cagtggagta cttacccgta cacgttcgga 300
ggggggacca agctggaaat aaagcg                                      326

<210> 27
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      light chain

<400> 27
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Gly Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65                  70                  75                  80  
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Thr Tyr Pro
                85                  90                  95      
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 


<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      light chain CDRL1

<400> 28
Ser Ser Val Ser Ser Ser Tyr
 1               5          


<210> 29
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      light chain CDRL2

<400> 29
Ser Thr Ser
 1          


<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 8.16C10
      light chain CDRL3

<400> 30
His Gln Trp Ser Thr Tyr Pro Tyr Thr
 1               5                  


<210> 31
<211> 233
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) heavy chain

<400> 31
ggcctgaaca gggcctggag tggattggat ggattgatcc tgagactggt aatactatat 60
atgacccgaa gttccagggc aaggccagta taacagctga cacatcctcc agcacagcct 120
acctgcagct caacagcctg acatctgagg acactgccgt ctattgctgt gctagaggct 180
ggtcctatgc tatggactac tggggtcaag gaacctcagt catcgtctcc tca        233

<210> 32
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) heavy chain

<400> 32
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys His Tyr
            20                  25                  30          
Tyr Ile His Trp Val Asn Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Ile Asp Pro Glu Thr Gly Asn Thr Ile Tyr Asp Pro Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Cys Cys
                85                  90                  95      
Ala Arg Gly Trp Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
            100                 105                 110         
Val Ile Val Ser Ser
        115         


<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) heavy chain CDRH1

<400> 33
Gly Phe Asn Ile Lys His Tyr Tyr
 1               5              


<210> 34
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) heavy chain CDRH2

<400> 34
Ile Asp Pro Glu Thr Gly Asn Thr
 1               5              


<210> 35
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) heavy chain CDRH3

<400> 35
Ala Arg Gly Trp Ser Tyr Ala Met Asp Tyr
 1               5                  10  


<210> 36
<211> 322
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) light chain

<400> 36
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc 60
atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca acagaaacca 120
ggacattctc ctaaactact gatttactcg gcatcctacc actacactgg agtccctgat 180
cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct 240
gaagacctgg cagtttatta ctgtcagcaa cattatagta ctccgtggac gttcggtgga 300
ggcaccaagc tggaaatcaa ac                                          322

<210> 37
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) light chain

<400> 37
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Tyr His Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 38
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) light chain CDRL1

<400> 38
Gln Asp Val Asn Thr Ala
 1               5      


<210> 39
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) light chain CDRL2

<400> 39
Ser Ala Ser
 1          


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.2H4
      (D2.1) light chain CDRL3

<400> 40
Gln Gln His Tyr Ser Thr Pro Trp Thr
 1               5                  


<210> 41
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) heavy chain

<400> 41
gaagtgaagc tggtggagtc tgggggaggt ttagtgcagc ctggagggtc cctgaatctc 60
tcctgtgcag cctctggatt cactttcagt agctatacca tgtcttgggt tcgccagact 120
ccagagaaga ggctggagtg ggtcgcatac attagtagtg gtggtcatag cacctacttt 180
ccagacactg taaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac 240
ctgcagatga gcagtctgaa gtctgaggac acggccgtgt attactgtgc aagagggggg 300
tatggtaact acgggcccta ctataatatg gactactggg gtcaaggaac ctcagtcacc 360
gtctcctca                                                         369

<210> 42
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) heavy chain

<400> 42
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Asn Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Gly His Ser Thr Tyr Phe Pro Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Gly Tyr Gly Asn Tyr Gly Pro Tyr Tyr Asn Met Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120             


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) heavy chain CDRH1

<400> 43
Gly Phe Thr Phe Ser Ser Tyr Thr
 1               5              


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) heavy chain CDRH2

<400> 44
Ile Ser Ser Gly Gly His Ser Thr
 1               5              


<210> 45
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) heavy chain CDRH3

<400> 45
Ala Arg Gly Gly Tyr Gly Asn Tyr Gly Pro Tyr Tyr Asn Met Asp Tyr
 1               5                  10                  15      


<210> 46
<211> 337
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) light chain

<400> 46
aacattatga tgacacagtc gccatcatct ctggctgtgt ctgcaggaga aaaggtcact 60
atgagctgta agtccagtca aagtgtttta tacagttcaa atcagaagaa ctacttggcc 120
tggtaccagc agaaaccagg gcagtctcct aaattgctga tctattgggc atccactagg 180
gaatctggtg tccctgatcg cttcacaggc agtggatctg ggacagattt tactcttacc 240
atcaacaatg tacaagctga agacctggca gtttattact gtcatcaata cctctcctcg 300
tggacgttcg gtggaggcac caagctggaa atcaaac                          337

<210> 47
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) light chain

<400> 47
Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Asn Asn Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln
                85                  90                  95      
Tyr Leu Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 48
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) light chain CDRL1

<400> 48
Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr
 1               5                  10          


<210> 49
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) light chain CDRL2

<400> 49
Trp Ala Ser
 1          


<210> 50
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12A6
      (D2.2) light chain CDRL3

<400> 50
His Gln Tyr Leu Ser Ser Trp Thr
 1               5              


<210> 51
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) heavy chain

<400> 51
tctgatgtgc agcttcagga gtcgggacct ggcctggtga aaccttctca gtctctgtcc 60
ctcacctgca ctgtcactgg ctactcaatc accagtgatt atgcctggaa ctggatccgg 120
cagtttccag gaaacaaact ggagtggatg ggctacataa gctacagtgg tagtattagc 180
tacaacccat ctctcaaaag tcgaatctct atcactcgag acacatccaa gaaccagttc 240
ttcctgcagt tgaattctgt gactactgag gacacagcca catattactg tgcaagatcc 300
gggaggttac gacgggactt tgactactgg ggccaaggca ccactctcac a          351

<210> 52
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) heavy chain

<400> 52
Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
 1               5                  10                  15      
Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser
            20                  25                  30          
Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu
        35                  40                  45              
Trp Met Gly Tyr Ile Ser Tyr Ser Gly Ser Ile Ser Tyr Asn Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr
                85                  90                  95      
Cys Ala Arg Ser Gly Arg Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Leu Thr
        115         


<210> 53
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) heavy chain CDRH1

<400> 53
Gly Tyr Ser Ile Thr Ser Asp Tyr Ala
 1               5                  


<210> 54
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) heavy chain CDRH2

<400> 54
Ile Ser Tyr Ser Gly Ser Ile
 1               5          


<210> 55
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) heavy chain CDRH3

<400> 55
Ala Arg Ser Gly Arg Leu Arg Arg Asp Phe Asp Tyr
 1               5                  10          


<210> 56
<211> 322
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) light chain

<400> 56
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt 60
ctcacttgtc gggcaagtca ggaaattagt ggttacttaa gttggcttca gcagaaacca 120
gatggaacta ttaaacgcct gatctacgcc gcatccactt tagattctgg tgtcccaaaa 180
aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct 240
gaagattttg cagactatta ctgtctacaa tatgctagtt atcctctcac gttcggtgct 300
gggaccaagc tggagctgaa ac                                          322

<210> 57
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) light chain

<400> 57
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr
            20                  25                  30          
Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
    50                  55                  60                  
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 58
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) light chain CDRL1

<400> 58
Gln Glu Ile Ser Gly Tyr
 1               5      


<210> 59
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) light chain CDRL2

<400> 59
Ala Ala Ser
 1          


<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.14B9
      (D2.3) light chain CDRL3

<400> 60
Leu Gln Tyr Ala Ser Tyr Pro Leu Thr
 1               5                  


<210> 61
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) heavy chain

<400> 61
gaagtgaacc tggtggagtc tgggggaggt ttagtgcagc ctggagggtc cctgaaactc 60
tcctgtgcag cctctggatt cactttcagt agctatacca tgtcttgggt tcgccagagt 120
ccagagaaga ggctggagtg ggtcgcatac actagtagta gtggtgccag cacctactat 180
ccagacactg taaagggccg attcaccatc tccagagaca atgccaagaa caccctgcac 240
ctgcaaatga gtagtctcaa gtctgaggac acggccatgt attactgtgc aagagggggg 300
tatggtaact acgggcccta ctatgctttg gactactggg gtcaaggaac ctcagtcacc 360
gtctcctca                                                         369

<210> 62
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) heavy chain

<400> 62
Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Thr Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Thr Ser Ser Ser Gly Ala Ser Thr Tyr Tyr Pro Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu His
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Gly Tyr Gly Asn Tyr Gly Pro Tyr Tyr Ala Leu Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120             


<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) heavy chain CDRH1

<400> 63
Gly Phe Thr Phe Ser Ser Tyr Thr
 1               5              


<210> 64
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) heavy chain CDRH2

<400> 64
Thr Ser Ser Ser Gly Ala Ser Thr
 1               5              


<210> 65
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) heavy chain CDRH3

<400> 65
Ala Arg Gly Gly Tyr Gly Asn Tyr Gly Pro Tyr Tyr Ala Leu Asp Tyr
 1               5                  10                  15      


<210> 66
<211> 337
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) light chain

<400> 66
aacattatga tgacacagtc gccatcatct ctggctgtgt ctgcaggaga aaaggtcact 60
atgagctgta agtccagtca aagtgtttta tacagttcaa atcagaagaa ctacttggcc 120
tggtaccagc agaaaccagg gcagtctcct aagctgctga tctactgggc atccactagg 180
gaatctggtg tccctgatcg cttcacaggc agtggatctg agacagattt tactcttacc 240
atcagcagtg tacaaactga agacctggca gtttattact gtcatcaata cctctcctcg 300
tggacgttcg gtggaggcac caagctggaa atcaaac                          337

<210> 67
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) light chain

<400> 67
Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Gln Thr Glu Asp Leu Ala Val Tyr Tyr Cys His Gln
                85                  90                  95      
Tyr Leu Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 68
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) light chain CDRL1

<400> 68
Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr
 1               5                  10          


<210> 69
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) light chain CDRL2

<400> 69
Trp Ala Ser
 1          


<210> 70
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 6.16F9
      (D2.4) light chain CDRL3

<400> 70
His Gln Tyr Leu Ser Ser Trp Thr
 1               5              


<210> 71
<211> 358
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      heavy chain

<400> 71
gaggttcagt tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata 60
tcctgcaagg cttctggtta ctcatttact ggctacttaa tgaactgggt gatgcagagc 120
catggaaaga gtcttgagtg gattggacgt attaatcctt acaatggtga tattttctac 180
aaccagaagt tcaaggacaa ggccacattg actgtagaca aatcctctag tacagcccac 240
atggagctcc ggagcctggc atctgaggac tctgcagtct attattgtgc aagaagggat 300
gagaactttg attatgacaa tgctatggac tactggggtc aaggaacctc agtcaccg   358

<210> 72
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      heavy chain

<400> 72
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
            20                  25                  30          
Leu Met Asn Trp Val Met Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asn Pro Tyr Asn Gly Asp Ile Phe Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Asp Glu Asn Phe Asp Tyr Asp Asn Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Leu
        115                 120 


<210> 73
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      heavy chain CDRH1

<400> 73
Gly Tyr Ser Phe Thr Gly Tyr Leu
 1               5              


<210> 74
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      heavy chain CDRH2

<400> 74
Ile Asn Pro Tyr Asn Gly Asp Ile
 1               5              


<210> 75
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      heavy chain CDRH3

<400> 75
Ala Arg Arg Asp Glu Asn Phe Asp Tyr Asp Asn Ala Met Asp Tyr
 1               5                  10                  15  


<210> 76
<211> 334
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      light chain

<400> 76
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 60
atatcctgca gagccagtga aagtgttgat atttatggca atagttttat gcactggtac 120
cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcgtccaa cctagaatct 180
gggatccctg ccaggttcag aggcagtggg tctaggacag acttcaccct caccatttat 240
cctgtggagg ctgatgatgt tgccacctat tactgtcagc aaagtaatga ggatccgtgg 300
acgttcggtg gaggcaccaa gctggaaatc aaac                             334

<210> 77
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      light chain

<400> 77
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ile Tyr
            20                  25                  30          
Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
    50                  55                  60                  
Arg Phe Arg Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Tyr
65                  70                  75                  80  
Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 78
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      light chain CDRL1

<400> 78
Glu Ser Val Asp Ile Tyr Gly Asn Ser Phe
 1               5                  10  


<210> 79
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      light chain CDRL2

<400> 79
Arg Ala Ser
 1          


<210> 80
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.1G12
      light chain CDRL3

<400> 80
Gln Gln Ser Asn Glu Asp Pro Trp Thr
 1               5                  


<210> 81
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      heavy chain

<400> 81
caggtccagc ttcagcagtc tggggctgaa ctggcaaaac ctggggtctc agtgaagatg 60
tcctgcaagg cttctggcta cacctctaat tataactgga tacattggat aaaacagagg 120
cctggacagg gtctggaatg gattggatac attaatcctg ccactggtta tactgactac 180
aatcagaagt tcagggacaa ggtcacattg actgcagaca aatcctccag cacagcctac 240
atgcaactga gtagtctgac atctgaggac tctgcactct attactgtac aacagggagg 300
aacgacgagg ggggctatgc tctggactcc tggggtcaag gaacctcagt caccgtctcc 360
tca                                                               363

<210> 82
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      heavy chain

<400> 82
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Val
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Ser Asn Tyr Asn
            20                  25                  30          
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ala Thr Gly Tyr Thr Asp Tyr Asn Gln Lys Phe
    50                  55                  60                  
Arg Asp Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys
                85                  90                  95      
Thr Thr Gly Arg Asn Asp Glu Gly Gly Tyr Ala Leu Asp Ser Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120     


<210> 83
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      heavy chain CDRH!

<400> 83
Gly Tyr Thr Ser Asn Tyr Asn Trp
 1               5              


<210> 84
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      heavy chain CDRH2

<400> 84
Ile Asn Pro Ala Thr Gly Tyr Thr
 1               5              


<210> 85
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      heavy chain CDRH3

<400> 85
Thr Thr Gly Arg Asn Asp Glu Gly Gly Tyr Ala Leu Asp Ser
 1               5                  10                  


<210> 86
<211> 309
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      light chain

<400> 86
ggcgttgtgg tgacccaatc tccaacttct ttggctgtgt ctctagggca gagggccacc 60
atctcctgca aggccagcca aagtgttgat catgctggtg atagttatat gaactggtac 120
caacagaaag cagggcagcc acccaaactc ctcatctatg gtgcatccta tctagaatct 180
gtgatcccag gcaggtttag tggcagtggg tctgggacag acttcaccct caacatccat 240
cctgtggagg aggaggatgt tgcaacctat ttctgtcagc aaagtaatga ggatccgtac 300
acgttcgga                                                         309

<210> 87
<211> 103
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      light chain

<400> 87
Gly Val Val Val Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp His Ala
            20                  25                  30          
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Gly Ala Ser Tyr Leu Glu Ser Val Ile Pro Gly
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly
            100             


<210> 88
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      light chain CDRL1

<400> 88
Gln Ser Val Asp His Ala Gly Asp Ser Tyr
 1               5                  10  


<210> 89
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      light chain CDRL2

<400> 89
Gly Ala Ser
 1          


<210> 90
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.2A5
      light chain CDRL3

<400> 90
Gln Gln Ser Asn Glu Asp Pro Tyr Thr
 1               5                  


<210> 91
<211> 353
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) heavy chain

<400> 91
caggtccaac tgcagcagtc tgggcctgag ctggtgaggc ctgggccttc aatgaggatg 60
tcctgcaagg cttcaggcta taccttcacc agctactgga tgtactgggt gaaaaagagg 120
cctggacaag gccttgaatg gattggcatg attgatcctt ccaagagtga aactaggtta 180
aatcagaagt gcgaggacaa ggccacattg aatggagaga aagcctccaa cacagcctac 240
atggaggtca gcagcctgac atctgatgac tctgcagtcc attactgtgc ccagtatggt 300
aaccacgtcc ttttgctaac tggggccaag ggacaccggt cactgtctct gca        353

<210> 92
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) heavy chain

<400> 92
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Pro
 1               5                  10                  15      
Ser Met Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met Tyr Trp Val Lys Lys Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile Asp Pro Ser Lys Ser Glu Thr Arg Leu Asn Gln Lys Cys
    50                  55                  60                  
Glu Asp Lys Ala Thr Leu Asn Gly Glu Lys Ala Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met Glu Val Ser Ser Leu Thr Ser Asp Asp Ser Ala Val His Tyr Cys
                85                  90                  95      
Ala Gln Tyr Gly Asn His Val Leu Leu Leu Thr Gly Ala Lys Gly His
            100                 105                 110         
Arg Ser Leu Ser Leu His
        115             


<210> 93
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) heavy chain CDRH1

<400> 93
Gly Tyr Thr Phe Thr Ser Tyr Trp
 1               5              


<210> 94
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) heavy chain CDRH2

<400> 94
Ile Asp Pro Ser Lys Ser Glu Thr
 1               5              


<210> 95
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) heavy chain CDRH3

<400> 95
Ala Gln Tyr Gly Asn His Val Leu Leu Leu Thr Gly Ala Lys Gly His
 1               5                  10                  15      
Arg Ser Leu Ser Leu His
            20          


<210> 96
<211> 325
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) light chain

<400> 96
gaaaatgtgc tcacccagtc tccagcaatc atgtctgcat ctccagggga aaaggtcacc 60
atgacctgca gggccagctc aagtgtgagt tccaattact tgcactggta ccagcagaag 120
tcaggtgcct cccccaaact ctggatttat agcacatcca acttggcttc tggagtccct 180
gatcgcttca ggggcagtgg gtctgggacc tcttactctc tcacaatcac cagtgtggag 240
gctgaagatg ctgccactta ctactgccag ctgtacagtg gttacccact cacgttcggt 300
gctgggacca agctggagct gaaac                                       325

<210> 97
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) light chain

<400> 97
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          
Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Arg
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Thr Ser Val Glu
65                  70                  75                  80  
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Leu Tyr Ser Gly Tyr Pro
                85                  90                  95      
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105             


<210> 98
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) light chain CDRL1

<400> 98
Ser Ser Val Ser Ser Asn Tyr
 1               5          


<210> 99
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) light chain CDRL2

<400> 99
Ser Thr Ser
 1          


<210> 100
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 33.14A5
      (D1.5-1) light chain CDRL3

<400> 100
Gln Leu Tyr Ser Gly Tyr Pro Leu Thr
 1               5                  


<210> 101
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      heavy chain

<400> 101
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctt agtcaagttg 60
tcctgcaaag cttctggctt caacattaaa gactactata tgtattggat gaagcagagg 120
cctgaacagg gcctggagtg gattggatgg attgatcctg agaatgttaa gactatatat 180
gacccgaagt tccagggcag ggccacttta acagcagaca catcctccaa cacagcctac 240
ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtac tagggacttc 300
ggctacgttg ggttcttcga tgtctggggc gcagggacca cggtcaccgt ctcctca    357

<210> 102
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      heavy chain

<400> 102
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr
            20                  25                  30          
Tyr Met Tyr Trp Met Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Ile Asp Pro Glu Asn Val Lys Thr Ile Tyr Asp Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Asp Phe Gly Tyr Val Gly Phe Phe Asp Val Trp Gly Ala Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser
        115                 


<210> 103
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      heavy chain CDRH1

<400> 103
Gly Phe Asn Ile Lys Asp Tyr Tyr
 1               5              


<210> 104
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      heavy chain CDRH2

<400> 104
Ile Asp Pro Glu Asn Val Lys Thr
 1               5              


<210> 105
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      heavy chain CDRH3

<400> 105
Thr Arg Asp Phe Gly Tyr Val Gly Phe Phe Asp Val
 1               5                  10          


<210> 106
<211> 323
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      light chain

<400> 106
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc 60
gtcaattgta aggccagtca gaatgtgggt actaatgtag tctggtatca acagaaacca 120
gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat 180
cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcac tgtgcagtct 240
gaagacttgg cagaatattt ctgtcagcaa tataacagct atcctctaac gttcggaggg 300
gggaccaagc tggaaataaa acg                                         323

<210> 107
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      light chain

<400> 107
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Val Asn Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
            20                  25                  30          
Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Val Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 108
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      light chain CDRL1

<400> 108
Gln Asn Val Gly Thr Asn
 1               5      


<210> 109
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      light chain CDRL2

<400> 109
Ser Ala Ser
 1          


<210> 110
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 27.12E12
      light chain CDRL3

<400> 110
Gln Gln Tyr Asn Ser Tyr Pro Leu Thr
 1               5                  


<210> 111
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      heavy chain

<400> 111
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc 60
tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact 120
ccggagagga agctggagtg ggtcgcaacc attagtagtg gtggtactta tacctactat 180
ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa ccgcctgtac 240
ctgcaaatga gcggtctgag gtctgagggc acggccatgt attactgtgt aagacctgac 300
tatactcacg acgacggcgg ttttgcttac tggggccaag ggactctggt cactgtctct 360
gca                                                               363

<210> 112
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      heavy chain

<400> 112
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Arg Lys Leu Glu Trp Val
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Gly Leu Arg Ser Glu Gly Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Val Arg Pro Asp Tyr Thr His Asp Asp Gly Gly Phe Ala Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ala
        115                 120     


<210> 113
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      heavy chain CDRH1

<400> 113
Gly Phe Thr Phe Ser Ser Tyr Ala
 1               5              


<210> 114
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      heavy chain CDRH2

<400> 114
Ile Ser Ser Gly Gly Thr Tyr Thr
 1               5              


<210> 115
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      heavy chain CDRH3

<400> 115
Val Arg Pro Asp Tyr Thr His Asp Asp Gly Gly Phe Ala Tyr
 1               5                  10                  


<210> 116
<211> 328
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      light chain

<400> 116
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc 60
acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa 120
aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt 180
cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca 240
cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ttgggtgttc 300
ggtggaggaa ccaaactgac tgtcctag                                    328

<210> 117
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      light chain

<400> 117
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
 1               5                  10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe
    50                  55                  60                  
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
65                  70                  75                  80  
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn
                85                  90                  95      
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 


<210> 118
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      light chain CDRL1

<400> 118
Gln Gly Ile Ser Asn Asn
 1               5      


<210> 119
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      light chain CDRL2

<400> 119
Asp Ala Ser
 1          


<210> 120
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic anti-T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) monoclonal antibody 9.1G12
      light chain CDRL3

<400> 120
Leu Gln His Arg Tyr Leu Pro His Val Arg Cys Trp
 1               5                  10          


<210> 121
<211> 2320
<212> DNA
<213> Homo sapiens

<220> 
<223> human T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428) coding sequence

<400> 121
gctcagtggg ggcggctact gctcatgtga ttgtggagta gacagttgga agaagtaccc 60
agtccatttg gagagttaaa actgtgccta acagaggtgt cctctgactt ttcttctgca 120
agctccatgt tttcacatct tccctttgac tgtgtcctgc tgctgctgct gctactactt 180
acaaggtcct cagaagtgga atacagagcg gaggtcggtc agaatgccta tctgccctgc 240
ttctacaccc cagccgcccc agggaacctc gtgcccgtct gctggggcaa aggagcctgt 300
cctgtgtttg aatgtggcaa cgtggtgctc aggactgatg aaagggatgt gaattattgg 360
acatccagat actggctaaa tggggatttc cgcaaaggag atgtgtccct gaccatagag 420
aatgtgattc tagcagacag tgggatctac tgctgccgga tccaaatccc aggcataatg 480
aatgatgaaa aatttaacct gaagttggtc atcaaaccag ccaaggtcac ccctgcaccg 540
actctgcaga gagacttcac tgcagccttt ccaaggatgc ttaccaccag gggacatggc 600
ccagcagaga cacagacact ggggagcctc cctgatataa atctaacaca aatatccaca 660
ttggccaatg agttacggga ctctagattg gccaatgact tacgggactc tggagcaacc 720
atcagaatag gcatctacat cggagcaggg atctgtgctg ggctggctct ggctcttatc 780
ttcggcgctt taattttcaa atggtattct catagcaaag agaagataca gaatttaagc 840
ctcatctctt tggccaacct ccctccctca ggattggcaa atgcagtagc agagggaatt 900
cgctcagaag aaaacatcta taccattgaa gagaacgtat atgaagtgga ggagcccaat 960
gagtattatt gctatgtcag cagcaggcag caaccctcac aacctttggg ttgtcgcttt 1020
gcaatgccat agatccaacc accttatttt tgagcttggt gttttgtctt tttcagaaac 1080
tatgagctgt gtcacctgac tggttttgga ggttctgtcc actgctatgg agcagagttt 1140
tcccattttc agaagataat gactcacatg ggaattgaac tgggacctgc actgaactta 1200
aacaggcatg tcattgcctc tgtatttaag ccaacagagt tacccaaccc agagactgtt 1260
aatcatggat gttagagctc aaacgggctt ttatatacac taggaattct tgacgtgggg 1320
tctctggagc tccaggaaat tcgggcacat catatgtcca tgaaacttca gataaactag 1380
ggaaaactgg gtgctgaggt gaaagcataa cttttttggc acagaaagtc taaaggggcc 1440
actgattttc aaagagatct gtgatccctt tttgtttttt gtttttgaga tggagtcttg 1500
ctctgttgcc caggctggag tgcaatggca caatctcggc tcactgcaag ctccgcctcc 1560
tgggttcaag cgattctcct gcctcagcct cctgagtggc tgggattaca ggcatgcacc 1620
accatgccca gctaatttgt tgtattttta gtagagacag ggtttcacca tgttggccag 1680
tgtggtctca aactcctgac ctcatgattt gcctgcctcg gcctcccaaa gcactgggat 1740
tacaggcgtg agccaccaca tccagccagt gatccttaaa agattaagag atgactggac 1800
taggtctacc ttgatcttga agattccctt ggaatgttga gatttaggct tatttgagca 1860
ctacctgccc aactgtcagt gccagtgcat agcccttctt ttgtctccct tatgaagact 1920
gccctgcagg gctgagatgt ggcaggagct cccagggaaa aaggaagtgc atttgattgg 1980
tgtgtattgg ccaagttttg cttgttgtgt gcttgaaaga aaatatctct gaccaacttc 2040
tgtattcgtg gaccaaactg aagctatatt tttcacagaa gaagaagcag tgacggggac 2100
acaaattctg ttgcctggtg gaaagaaggc aaaggccttc agcaatctat attaccagcg 2160
ctggatcctt tgacagagag tggtccctaa acttaaattt caagacggta taggcttgat 2220
ctgtcttgct tattgttgcc ccctgcgcct agcacaattt tgacacacaa ttggaactta 2280
ctaaaaattt ttttttactg ttaaaaaaaa aaaaaaaaaa                       2320

<210> 122
<211> 301
<212> PRT
<213> Homo sapiens

<220> 
<223> human T cell immunoglobulin- and mucin
      domain-containing molecule 3 (TIM3, HAVCR2, KIM-3,
      TIMD3, and FLJ14428)

<220> 
<221> DOMAIN         
<222> (22)...(202)
<223> extracellular domain

<220> 
<221> DOMAIN         
<222> (203)...(223)
<223> transmembrane domain

<220> 
<221> DOMAIN         
<222> (224)...(301)
<223> cytoplasmic domain

<400> 122
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln
            20                  25                  30          
Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu
        35                  40                  45              
Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly
    50                  55                  60                  
Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser
65                  70                  75                  80  
Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr
                85                  90                  95      
Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile
            100                 105                 110         
Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val
        115                 120                 125             
Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe
    130                 135                 140                 
Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala
145                 150                 155                 160 
Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile
                165                 170                 175     
Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu
            180                 185                 190         
Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly
        195                 200                 205             
Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe
    210                 215                 220                 
Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile
225                 230                 235                 240 
Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu
                245                 250                 255     
Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr
            260                 265                 270         
Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln
        275                 280                 285             
Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro
    290                 295                 300     



