                         SEQUENCE LISTING

<110>  University of Washington
       Schief, William
       Correia, Bruno
 
<120>  Methods for Design of Epitope Scaffold for mAb b12

<130>  12-653-PCT

<150>  61/503526
<151>  2011-06-30

<150>  61/548661
<151>  2011-10-18

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is N or D

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X is P or V

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is D or G

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is G, T, or v

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  X is D or S

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  X is N or Q

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is F, E or P

<220>
<221>  MISC_FEATURE
<222>  (84)..(85)
<223>  X is E or A

<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  X is G or L

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  X is G or Y

<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  X is A, V or L

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (120)..(120)
<223>  X is A or E

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  X is A or W

<220>
<221>  MISC_FEATURE
<222>  (122)..(122)
<223>  X is W or L

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  X is F, T, M or s

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  X is Q or K

<220>
<221>  MISC_FEATURE
<222>  (156)..(156)
<223>  X is M or W

<220>
<221>  MISC_FEATURE
<222>  (158)..(158)
<223>  X is A, P or R

<400>  1

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Xaa Xaa Xaa Pro Xaa Gly Asp Met Xaa 
65                  70                  75                  80  


Xaa Gly Xaa Xaa Xaa Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Asp Pro Xaa Xaa Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Xaa Xaa Ala Xaa Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala 
        


<210>  2
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is T or V

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is E or P

<220>
<221>  MISC_FEATURE
<222>  (84)..(85)
<223>  X is E or A

<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  X is V or L

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  X is T, M or S

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  X is Q or K

<220>
<221>  MISC_FEATURE
<222>  (156)..(156)
<223>  X is M or W

<220>
<221>  MISC_FEATURE
<222>  (158)..(158)
<223>  X is A, P or R

<400>  2

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Val Gly Pro Xaa Gly Asp Met Ser 
65                  70                  75                  80  


Gln Gly Xaa Xaa Xaa Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Asp Pro Leu Tyr Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Xaa Gln Glu Trp Leu Arg Xaa Val Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Xaa Xaa Ala Xaa Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala 
        


<210>  3
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asn Pro Asp Pro Gly Gly Asp Met Asp 
65                  70                  75                  80  


Asn Gly Phe Glu Glu Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Asp Pro Gly Gly Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Ala Glu Ala Ala Trp Arg Phe Ala Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Gln Met Ala Ala Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala 
        


<210>  4
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Val Gly Pro Thr Gly Asp Met Ser 
65                  70                  75                  80  


Gln Gly Glu Glu Ala Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Tyr Pro Leu Tyr Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Val Gln Glu Trp Leu Arg Thr Val Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Gln Met Ala Ala Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala 
        


<210>  5
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Val Gly Pro Thr Gly Asp Met Ser 
65                  70                  75                  80  


Gln Gly Pro Glu Ala Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Tyr Pro Leu Tyr Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Val Gln Glu Trp Leu Arg Met Val Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Gln Met Ala Ala Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala 
        


<210>  6
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Val Gly Pro Thr Gly Asp Met Ser 
65                  70                  75                  80  


Gln Gly Glu Glu Ala Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Tyr Pro Leu Tyr Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Ala Gln Glu Trp Leu Arg Thr Val Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Gln Met Ala Ala Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala 
        


<210>  7
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Val Gly Pro Val Gly Asp Met Ser 
65                  70                  75                  80  


Gln Gly Glu Glu Ala Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Tyr Pro Leu Tyr Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Val Gln Glu Trp Leu Arg Ser Val Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Gln Met Ala Ala Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala 
        


<210>  8
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Val Gly Pro Thr Gly Asp Met Ser 
65                  70                  75                  80  


Gln Gly Glu Glu Ala Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Tyr Pro Leu Tyr Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Leu Gln Glu Trp Leu Arg Thr Val Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Gln Met Ala Ala Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala Gly 
        275 


<210>  9
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Val Gly Pro Thr Gly Asp Met Ser 
65                  70                  75                  80  


Gln Gly Glu Glu Ala Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Tyr Pro Leu Tyr Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Val Gln Glu Trp Leu Arg Thr Val Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Gln Met Ala Arg Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala Gly 
        275 


<210>  10
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Val Gly Pro Thr Gly Asp Met Ser 
65                  70                  75                  80  


Gln Gly Glu Glu Ala Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Tyr Pro Leu Tyr Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Val Gln Glu Trp Leu Arg Thr Val Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Lys Met Ala Ala Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala Gly 
        275 


<210>  11
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Val Gly Pro Thr Gly Asp Met Ser 
65                  70                  75                  80  


Gln Gly Glu Glu Ala Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Tyr Pro Leu Tyr Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Val Gln Glu Trp Leu Arg Thr Val Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Lys Trp Ala Arg Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala Gly 
        275 


<210>  12
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  X is A or V

<400>  12

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Ala Pro Asp Met Gly Asp Met Gln 
65                  70                  75                  80  


Thr Ser Glu Gly Val Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Glu Cys Pro Leu Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Xaa Ala Leu Leu Ser Ile His Cys Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Gln Met Ala Ala Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala 
        


<210>  13
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp His Asn Gln His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Asp Ala Pro Asp Met Gly Asp Met Gln 
65                  70                  75                  80  


Thr Ser Glu Gly Val Gly Lys Gln Trp Ile Asp Glu Phe Ala Ala Gly 
                85                  90                  95      


Leu Lys Asn Arg Pro Ala Tyr Ile Ile Val Glu Cys Pro Leu Ser Gly 
            100                 105                 110         


Gly Asp Pro Glu Ile Val Ala Leu Leu Ser Ile His Cys Ala Tyr Ala 
        115                 120                 125             


Gly Lys Ala Leu Lys Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp 
    130                 135                 140                 


Ala Gly His Ser Ala Trp His Ser Pro Ala Gln Met Ala Ala Ala Leu 
145                 150                 155                 160 


Gln Arg Ala Asp Ile Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr 
                165                 170                 175     


Ser Asn Tyr Arg Trp Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val 
            180                 185                 190         


Leu Ser Ala Ile Gly Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser 
        195                 200                 205             


Arg Asn Gly Asn Gly Pro Ala Gly Asn Glu Ser Cys Asp Pro Ser Gly 
    210                 215                 220                 


Arg Ala Ile Gly Thr Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile 
225                 230                 235                 240 


Asp Ala Phe Leu Trp Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile 
                245                 250                 255     


Ala Gly Ala Gly Gln Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile 
            260                 265                 270         


Ala Ala 
        


<210>  14
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ser Leu Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Met 
            20              


<210>  15
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Asp Ser Pro Phe Tyr Val Asn Pro Asn Met Ser Ser Ala Glu Trp Val 
1               5                   10                  15      


Arg Asn Asn Pro Asn Asp Pro Arg Thr Pro Val Ile Arg Asp Arg Ile 
            20                  25                  30          


Ala Ser Val Pro Gln Gly Thr Trp Phe Ala His His Asn Pro Gly Gln 
        35                  40                  45              


Ile Thr Gly Gln Val Asp Ala Leu Met Ser Ala Ala Gln Ala Ala Gly 
    50                  55                  60                  


Lys Ile Pro Ile Leu Val Val Tyr Asn Ala Pro Gly Arg Asp Cys Gly 
65                  70                  75                  80  


Asn His Ser Ser Gly Gly Ala Pro Ser His Ser Ala Tyr Arg Ser Trp 
                85                  90                  95      


Ile Asp Glu Phe Ala Ala Gly Leu Lys Asn Arg Pro Ala Tyr Ile Ile 
            100                 105                 110         


Val Glu Pro Asp Leu Ile Ser Leu Met Ser Ser Cys Met Gln His Val 
        115                 120                 125             


Gln Gln Glu Val Leu Glu Thr Met Ala Tyr Ala Gly Lys Ala Leu Lys 
    130                 135                 140                 


Ala Gly Ser Ser Gln Ala Arg Ile Tyr Phe Asp Ala Gly His Ser Ala 
145                 150                 155                 160 


Trp His Ser Pro Ala Gln Met Ala Ser Trp Leu Gln Gln Ala Asp Ile 
                165                 170                 175     


Ser Asn Ser Ala His Gly Ile Ala Thr Asn Thr Ser Asn Tyr Arg Trp 
            180                 185                 190         


Thr Ala Asp Glu Val Ala Tyr Ala Lys Ala Val Leu Ser Ala Ile Gly 
        195                 200                 205             


Asn Pro Ser Leu Arg Ala Val Ile Asp Thr Ser Arg Asn Gly Asn Gly 
    210                 215                 220                 


Pro Ala Gly Asn Glu Trp Cys Asp Pro Ser Gly Arg Ala Ile Gly Thr 
225                 230                 235                 240 


Pro Ser Thr Thr Asn Thr Gly Asp Pro Met Ile Asp Ala Phe Leu Trp 
                245                 250                 255     


Ile Lys Leu Pro Gly Glu Ala Asp Gly Cys Ile Ala Gly Ala Gly Gln 
            260                 265                 270         


Phe Val Pro Gln Ala Ala Tyr Glu Met Ala Ile Ala Ala 
        275                 280                 285 


