                                     SEQUENCE LISTING	

<110> TRUSTEES OF BOSTON UNIVERSITY
 
<120> METHOD FOR CONTROLLING TUMOR GROWTH, ANGIOGENESIS AND METASTASIS 
      USING IMMUNOGLOBULIN CONTAINING AND PROLINE RICH RECEPTOR-1 
      (IGPR-1)

<130> 701586-069841-PCT

<140>
<141>

<150> 61/503,392
<151> 2011-06-30

<160> 24    

<170> PatentIn version 3.5

<210> 1
<211> 282
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser 
145                 150                 155                 160 


Met Gly Val Ala Ala Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg 
                165                 170                 175     


Ser Cys Gln Gln Arg Asp Ser Gly Asn Ser Pro Gly Asn Ala Phe Tyr 
            180                 185                 190         


Ser Asn Val Leu Tyr Arg Pro Arg Gly Pro Pro Lys Lys Ser Glu Asp 
        195                 200                 205             


Cys Ser Gly Glu Gly Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr 
    210                 215                 220                 


Ser Phe Pro Gln Pro Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro 
225                 230                 235                 240 


Cys Pro Ser Pro Arg Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val 
                245                 250                 255     


Ser Met Val Arg Val Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg 
            260                 265                 270         


Pro Lys Gly Phe Pro Lys Val Gly Glu Glu 
        275                 280         


<210> 2
<211> 1282
<212> DNA
<213> Homo sapiens

<400> 2
ggaagtctgt caactgggag ggggagaggg gggtgatggg ccaggaatgg ggtccccggg       60

catggtgctg ggcctcctgg tgcagatctg ggccctgcaa gaagcctcaa gcctgagcgt      120

gcagcagggg cccaacttgc tgcaggtgag gcagggcagt caggcgaccc tggtctgcca      180

ggtggaccag gccacagcct gggaacggct ccgtgttaag tggacaaagg atggggccat      240

cctgtgtcaa ccgtacatca ccaacggcag cctcagcctg ggggtctgcg ggccccaggg      300

acggctctcc tggcaggcac ccagccatct caccctgcag ctggaccctg tgagcctcaa      360

ccacagcggg gcgtacgtgt gctgggcggc cgtagagatt cctgagttgg aggaggctga      420

gggcaacata acaaggctct ttgtggaccc agatgacccc acacagaaca gaaaccggat      480

cgcaagcttc ccaggattcc tcttcgtgct gctgggggtg ggaagcatgg gtgtggctgc      540

gatcgtgtgg ggtgcctggt tctggggccg ccgcagctgc cagcaaaggg actcaggtaa      600

cagcccagga aatgcattct acagcaacgt cctataccgg ccccgggggg ccccaaagaa      660

gagtgaggac tgctctggag aggggaagga ccagaggggc cagagcattt attcaacctc      720

cttcccgcaa ccggcccccc gccagccgca cctggcgtca agaccctgcc ccagcccgag      780

accctgcccc agccccaggc ccggccaccc cgtctctatg gtcagggtct ctcctagacc      840

aagccccacc cagcagccga ggccaaaagg gttccccaaa gtgggagagg agtgagagat      900

cccaggagac ctcaacagga ccccacccat aggtacacac aaaaaagggg ggatcgaggc      960

cagacacggt ggctcacgcc tgtaatccca gcagtttggg aagccgaggc gggtggaaca     1020

cttgaggtca ggggtttgag accagcctgg cttgaacctg ggaggcggag gttgcagtga     1080

gccgagattg cgccactgca ctccagcctg ggcgacagag tgagactccg tctcaaaaaa     1140

aacaaaaagc aggaggattg ggagcctgtc agccccatcc tgagaccccg tcctcatttc     1200

tgtaatgatg gatctcgctc ccactttccc ccaagaacct aataaaggct tgtgaagaaa     1260

aagcaaaaaa aaaaaaaaaa aa                                              1282


<210> 3

<400> 3
000


<210> 4
<211> 149
<212> PRT
<213> Homo sapiens

<400> 4
Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg Ile Ala Ser Phe Pro 
1               5                   10                  15      


Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser Met Gly Val Ala Ala 
            20                  25                  30          


Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg Ser Cys Gln Gln Arg 
        35                  40                  45              


Asp Ser Gly Asn Ser Pro Gly Asn Ala Phe Tyr Ser Asn Val Leu Tyr 
    50                  55                  60                  


Arg Pro Arg Gly Pro Pro Lys Lys Ser Glu Asp Cys Ser Gly Glu Gly 
65                  70                  75                  80  


Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr Ser Phe Pro Gln Pro 
                85                  90                  95      


Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro Cys Pro Ser Pro Arg 
            100                 105                 110         


Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val Ser Met Val Arg Val 
        115                 120                 125             


Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg Pro Lys Gly Phe Pro 
    130                 135                 140                 


Lys Val Gly Glu Glu 
145                 


<210> 5
<211> 127
<212> PRT
<213> Homo sapiens

<400> 5
Leu Ser Val Gln Gln Gly Pro Asn Leu Leu Gln Val Arg Gln Gly Ser 
1               5                   10                  15      


Gln Ala Thr Leu Val Cys Gln Val Asp Gln Ala Thr Ala Trp Glu Arg 
            20                  25                  30          


Leu Arg Val Lys Trp Thr Lys Asp Gly Ala Ile Leu Cys Gln Pro Tyr 
        35                  40                  45              


Ile Thr Asn Gly Ser Leu Ser Leu Gly Val Cys Gly Pro Gln Gly Arg 
    50                  55                  60                  


Leu Ser Trp Gln Ala Pro Ser His Leu Thr Leu Gln Leu Asp Pro Val 
65                  70                  75                  80  


Ser Leu Asn His Ser Gly Ala Tyr Val Cys Trp Ala Ala Val Glu Ile 
                85                  90                  95      


Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile Thr Arg Leu Phe Val Asp 
            100                 105                 110         


Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg Ile Ala Ser Phe Pro 
        115                 120                 125         


<210> 6
<211> 111
<212> PRT
<213> Homo sapiens

<400> 6
Leu Ser Val Gln Gln Gly Pro Asn Leu Leu Gln Val Arg Gln Gly Ser 
1               5                   10                  15      


Gln Ala Thr Leu Val Cys Gln Val Asp Gln Ala Thr Ala Trp Glu Arg 
            20                  25                  30          


Leu Arg Val Lys Trp Thr Lys Asp Gly Ala Ile Leu Cys Gln Pro Tyr 
        35                  40                  45              


Ile Thr Asn Gly Ser Leu Ser Leu Gly Val Cys Gly Pro Gln Gly Arg 
    50                  55                  60                  


Leu Ser Trp Gln Ala Pro Ser His Leu Thr Leu Gln Leu Asp Pro Val 
65                  70                  75                  80  


Ser Leu Asn His Ser Gly Ala Tyr Val Cys Trp Ala Ala Val Glu Ile 
                85                  90                  95      


Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile Thr Arg Leu Phe Val 
            100                 105                 110     


<210> 7
<211> 22
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser 
            20          


<210> 8
<211> 3023
<212> DNA
<213> Homo sapiens

<400> 8
ggcgggacaa ccgcggcgcg gctcggcgct cccggcctgg cgttgtggcg ccgcagccct       60

tgccaccttc cctgcacctg ccctgcccgg cctcatgtac cgcgcgctgt acgcgttccg      120

ctcggcggag cccaacgcgc tggcgttcgc cgcgggcgag accttcctgg tgctagagcg      180

aagcagcgcg cactggtggc tggccgcgcg ggcgcgcagt ggtgagacgg gctacgtgcc      240

gccagcctac ctgcgccgcc tgcagggcct ggagcaggat gtcctccagg ccattgaccg      300

ggccatcgag gctgtacaca acacagccat gcgggatggt ggcaagtaca gcctggaaca      360

gcgtggagtc ctccagaagc tgatccacca ccggaaagag accctgtcac gcagaggccc      420

ttcagcctcc agtgttgcag ttatgacctc atcaaccagt gaccaccact tggatgctgc      480

tgcagccagg cagcccaatg gggtgtgtcg agctgggttc gagcggcagc acagcctacc      540

cagttctgag catcttgggg cagatggagg cctctaccag atcccacttc catcttccca      600

gatcccacca cagcctcgcc gagcagcacc caccacaccg cccccaccag tgaagcgccg      660

agaccgcgag gccctgatgg cctctgggag tggtggccac aacaccatgc cctccggggg      720

taactctgtg tccagcggct cctcagtcag cagcacctcc ctggacacgc tctataccag      780

ctccagccca tctgaaccag gctccagctg ctcacccaca cccccacctg tgccccgccg      840

aggcacccac accaccgtgt cccaagtcca gccccctccc tccaaggcat cagcacctga      900

accccctgca gaagaagaag tggcaactgg tacaacctca gcctctgatg acctggaagc      960

cctgggtaca ctgagcctgg ggaccacaga ggagaaggca gcagctgagg cggctgtgcc     1020

caggaccatt ggggccgagc tgatggagct ggtgcggaga aacactggcc tgagccacga     1080

attatgccgg gtggccatcg gcatcatagt gggtcacatc caggcctcgg tgccggccag     1140

ctcaccagtc atggagcagg tcctcctctc actcgtagag ggcaaggacc tcagcatggc     1200

cctgccctca gggcaggtct gccacgacca gcagaggctg gaggtgatct ttgcagacct     1260

ggctcgccgg aaggacgacg cccagcagcg cagttgggca ctatatgagg atgagggtgt     1320

catccgctgc tacctagagg agctgctgca tattctgact gatgcagacc ctgaagtttg     1380

caagaaaatg tgcaagagaa acgagttcga gtctgtcctg gccttggtgg cctattacca     1440

aatggaacac cgagcatcac tgcggctgct gctcctcaag tgctttggcg ccatgtgcag     1500

cctggatgca gccatcatct ccacgcttgt gtcatccgtg ctgcctgtag agctggcgag     1560

ggacatgcag acagacacgc aggaccacca gaaactctgt tactctgccc tcatcctggc     1620

catggtcttc tccatgggag aggcagtgcc ctatgcacac tatgagcacc tgggcacgcc     1680

tttcgcccag ttcctactga acatcgtcga ggatgggctg cccttggaca ccacagagca     1740

gctgccggac ctctgcgtga acctgcttct ggctctcaac ctgcacctgc cagctgctga     1800

ccagaatgtc atcatggctg ccctgagcaa acacgccaat gtcaagatct tctccgagaa     1860

gctgttgttg ctcctgaaca gaggggatga ccctgtgcgc atcttcaaac atgagccaca     1920

gccaccacac tctgtcctca agttcctgca ggacgtgttt ggcagcccgg ccacagctgc     1980

catcttctac cacacagaca tgatggctct cattgacatc actgtgcggc acatcgcaga     2040

cctgtcacca ggagacaagc tgcgcatgga gtacctctcc ctgatgcatg ctatagtccg     2100

caccacaccc tacctgcagc accgccaccg gctacccgac ctgcaggcca tactgcgacg     2160

catcctgaat gaggaggaga cctcacccca gtgccagatg gaccgcatga ttgtccgaga     2220

gatgtgcaag gaattcctgg tgctggggga ggctcccagc tagcaccttg ctgtcctccc     2280

ttccctgcag ctccagtcag tgtgcagggg actcaggggc ttggccctaa gaatgttttg     2340

cactgacagt gggaggggat aaggtggcag aaggaacctg agcaggaccc ccacctgaag     2400

tagaacttaa gagaggggcc aagtgtagga ttggggacca tggtctggga gctgttctgg     2460

ggcaggggga atatgcaagc taaagcccct ctataccctg gtaggcttcc tcttcagcat     2520

gcccccctct tcaccccaca cccatgtgta cactcagagt cctgctgccg ctccaggctg     2580

gaccagaccc ccatccccac ccctcctggt ctgtatcctg ggcctcagca agccatgccc     2640

ctggggtgag gggaggcatc tcccaccagc tctattcttt gccttagctt tgcagtgagt     2700

gctgctcatg tcctcccctc cacccgcaca tgggggtcgc tgcccttcac tcctaccccc     2760

agaggccttg gccaagctgc tgctttgaaa gcgggatctt ggagacaggc catccatcct     2820

ggagcctcat ggaacaggat gatggcactg agaaagccaa tgaccgaatc tcttttctct     2880

gtaaaaatgt agactgaaaa gccatgtgta ttttcctatg tgctgtagct ctcctttgga     2940

aataaatcac aggcatctgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3000

aaaaaaaaaa aaaaaaaaaa aaa                                             3023


<210> 9
<211> 2968
<212> DNA
<213> Homo sapiens

<400> 9
ggcgggacaa ccgcggcgcg gctcggcgct cccggcctgg cgttgtggcg ccgcagccct       60

tgccaccttc cctgcacctg ccctgcccgg cctcatgtac cgcgcgctgt acgcgttccg      120

ctcggcggag cccaacgcgc tggcgttcgc cgcgggcgag accttcctgg tgctagagcg      180

aagcagcgcg cactggtggc tggccgcgcg ggcgcgcagt ggtgagacgg gctacgtgcc      240

gccagcctac ctgcgccgcc tgcagggcct ggagcaggat gtcctccagg ccattgaccg      300

ggccatcgag gctgtacaca acacagccat gcgggatggt ggcaagtaca gcctggaaca      360

gcgtggagtc ctccagaagc tgatccacca ccggaaagag accctgtcac gcagaggccc      420

ttcagcctcc agtgttgcag ttatgacctc atcaaccagt gaccaccact tggatgctgc      480

tgcagccagg cagcccaatg gggtgtgtcg agctgggttc gagcggcagc acagcctacc      540

cagttctgag catcttgggg cagatggagg cctctaccag atcccaccac agcctcgccg      600

agcagcaccc accacaccgc ccccaccagt gaagcgccga gaccgcgagg ccctgatggc      660

ctctgggagt ggtggccaca acaccatgcc ctccgggggt aactctgtgt ccagcggctc      720

ctcagtcagc agcacctccc tggacacgct ctataccagc tccagcccat ctgaaccagg      780

ctccagctgc tcacccacac ccccacctgt gccccgccga ggcacccaca ccaccgtgtc      840

ccaagtccag ccccctccct ccaaggcatc agcacctgaa ccccctgcag aagaagaagt      900

ggcaactggt acaacctcag cctctgatga cctggaagcc ctgggtacac tgagcctggg      960

gaccacagag gagaaggcag cagctgaggc ggctgtgccc aggaccattg gggccgagct     1020

gatggagctg gtgcggagaa acactggcct gagccacgaa ttatgccggg tggccatcgg     1080

catcatagtg ggtcacatcc aggcctcggt gccggccagc tcaccagtca tggagcaggt     1140

cctcctctca ctcgtagagg gcaaggacct cagcatggcc ctgccctcag ggcaggtctg     1200

ccacgaccag cagaggctgg aggtgatctt tgcagacctg gctcgccgga aggacgacgc     1260

ccagcagcgc agttgggcac tatatgagga tgagggtgtc atccgctgct acctagagga     1320

gctgctgcat attctgactg atgcagaccc tgaagtttgc aagaaaatgt gcaagagaaa     1380

cgagttcgag tctgtcctgg ccttggtggc ctattaccaa atggaacacc gagcatcact     1440

gcggctgctg ctcctcaagt gctttggcgc catgtgcagc ctggatgcag ccatcatctc     1500

cacgcttgtg tcatccgtgc tgcctgtaga gctggcgagg gacatgcaga cagacacgca     1560

ggaccaccag aaactctgtt actctgccct catcctggcc atggtcttct ccatgggaga     1620

ggcagtgccc tatgcacact atgagcacct gggcacgcct ttcgcccagt tcctactgaa     1680

catcgtcgag gatgggctgc ccttggacac cacagagcag ctgccggacc tctgcgtgaa     1740

cctgcttctg gctctcaacc tgcacctgcc agctgctgac cagaatgtca tcatggctgc     1800

cctgagcaaa cacgccaatg tcaagatctt ctccgagaag ctgttgttgc tcctgaacag     1860

aggggatgac cctgtgcgca tcttcaaaca tgagccacag ccaccacact ctgtcctcaa     1920

gttcctgcag gacgtgtttg gcagcccggc cacagctgcc atcttctacc acacagacat     1980

gatggctctc attgacatca ctgtgcggca catcgcagac ctgtcaccag gagacaagct     2040

gcgcatggag tacctctccc tgatgcatgc tatagtccgc accacaccct acctgcagca     2100

ccgccaccgg ctacccgacc tgcaggccat actgcgacgc atcctgaatg aggaggagac     2160

ctcaccccag tgccagatgg accgcatgat tgtccgagag atgtgcaagg aattcctggt     2220

gctgggggag gctcccagct agcaccttgc tgtcctccct tccctgcagc tccagtcagt     2280

gtgcagggga ctcaggggct tggccctaag aatgttttgc actgacagtg ggaggggata     2340

aggtggcaga aggaacctga gcaggacccc cacctgaagt agaacttaag agaggggcca     2400

agtgtaggat tggggaccat ggtctgggag ctgttctggg gcagggggaa tatgcaagct     2460

aaagcccctc tataccctgg taggcttcct cttcagcatg cccccctctt caccccacac     2520

ccatgtgtac actcagagtc ctgctgccgc tccaggctgg accagacccc catccccacc     2580

cctcctggtc tgtatcctgg gcctcagcaa gccatgcccc tggggtgagg ggaggcatct     2640

cccaccagct ctattctttg ccttagcttt gcagtgagtg ctgctcatgt cctcccctcc     2700

acccgcacat gggggtcgct gcccttcact cctaccccca gaggccttgg ccaagctgct     2760

gctttgaaag cgggatcttg gagacaggcc atccatcctg gagcctcatg gaacaggatg     2820

atggcactga gaaagccaat gaccgaatct cttttctctg taaaaatgta gactgaaaag     2880

ccatgtgtat tttcctatgt gctgtagctc tcctttggaa ataaatcaca ggcatctgga     2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                        2968


<210> 10
<211> 722
<212> PRT
<213> Homo sapiens

<400> 10
Met Tyr Arg Ala Leu Tyr Ala Phe Arg Ser Ala Glu Pro Asn Ala Leu 
1               5                   10                  15      


Ala Phe Ala Ala Gly Glu Thr Phe Leu Val Leu Glu Arg Ser Ser Ala 
            20                  25                  30          


His Trp Trp Leu Ala Ala Arg Ala Arg Ser Gly Glu Thr Gly Tyr Val 
        35                  40                  45              


Pro Pro Ala Tyr Leu Arg Arg Leu Gln Gly Leu Glu Gln Asp Val Leu 
    50                  55                  60                  


Gln Ala Ile Asp Arg Ala Ile Glu Ala Val His Asn Thr Ala Met Arg 
65                  70                  75                  80  


Asp Gly Gly Lys Tyr Ser Leu Glu Gln Arg Gly Val Leu Gln Lys Leu 
                85                  90                  95      


Ile His His Arg Lys Glu Thr Leu Ser Arg Arg Gly Pro Ser Ala Ser 
            100                 105                 110         


Ser Val Ala Val Met Thr Ser Ser Thr Ser Asp His His Leu Asp Ala 
        115                 120                 125             


Ala Ala Ala Arg Gln Pro Asn Gly Val Cys Arg Ala Gly Phe Glu Arg 
    130                 135                 140                 


Gln His Ser Leu Pro Ser Ser Glu His Leu Gly Ala Asp Gly Gly Leu 
145                 150                 155                 160 


Tyr Gln Ile Pro Leu Pro Ser Ser Gln Ile Pro Pro Gln Pro Arg Arg 
                165                 170                 175     


Ala Ala Pro Thr Thr Pro Pro Pro Pro Val Lys Arg Arg Asp Arg Glu 
            180                 185                 190         


Ala Leu Met Ala Ser Gly Ser Gly Gly His Asn Thr Met Pro Ser Gly 
        195                 200                 205             


Gly Asn Ser Val Ser Ser Gly Ser Ser Val Ser Ser Thr Ser Leu Asp 
    210                 215                 220                 


Thr Leu Tyr Thr Ser Ser Ser Pro Ser Glu Pro Gly Ser Ser Cys Ser 
225                 230                 235                 240 


Pro Thr Pro Pro Pro Val Pro Arg Arg Gly Thr His Thr Thr Val Ser 
                245                 250                 255     


Gln Val Gln Pro Pro Pro Ser Lys Ala Ser Ala Pro Glu Pro Pro Ala 
            260                 265                 270         


Glu Glu Glu Val Ala Thr Gly Thr Thr Ser Ala Ser Asp Asp Leu Glu 
        275                 280                 285             


Ala Leu Gly Thr Leu Ser Leu Gly Thr Thr Glu Glu Lys Ala Ala Ala 
    290                 295                 300                 


Glu Ala Ala Val Pro Arg Thr Ile Gly Ala Glu Leu Met Glu Leu Val 
305                 310                 315                 320 


Arg Arg Asn Thr Gly Leu Ser His Glu Leu Cys Arg Val Ala Ile Gly 
                325                 330                 335     


Ile Ile Val Gly His Ile Gln Ala Ser Val Pro Ala Ser Ser Pro Val 
            340                 345                 350         


Met Glu Gln Val Leu Leu Ser Leu Val Glu Gly Lys Asp Leu Ser Met 
        355                 360                 365             


Ala Leu Pro Ser Gly Gln Val Cys His Asp Gln Gln Arg Leu Glu Val 
    370                 375                 380                 


Ile Phe Ala Asp Leu Ala Arg Arg Lys Asp Asp Ala Gln Gln Arg Ser 
385                 390                 395                 400 


Trp Ala Leu Tyr Glu Asp Glu Gly Val Ile Arg Cys Tyr Leu Glu Glu 
                405                 410                 415     


Leu Leu His Ile Leu Thr Asp Ala Asp Pro Glu Val Cys Lys Lys Met 
            420                 425                 430         


Cys Lys Arg Asn Glu Phe Glu Ser Val Leu Ala Leu Val Ala Tyr Tyr 
        435                 440                 445             


Gln Met Glu His Arg Ala Ser Leu Arg Leu Leu Leu Leu Lys Cys Phe 
    450                 455                 460                 


Gly Ala Met Cys Ser Leu Asp Ala Ala Ile Ile Ser Thr Leu Val Ser 
465                 470                 475                 480 


Ser Val Leu Pro Val Glu Leu Ala Arg Asp Met Gln Thr Asp Thr Gln 
                485                 490                 495     


Asp His Gln Lys Leu Cys Tyr Ser Ala Leu Ile Leu Ala Met Val Phe 
            500                 505                 510         


Ser Met Gly Glu Ala Val Pro Tyr Ala His Tyr Glu His Leu Gly Thr 
        515                 520                 525             


Pro Phe Ala Gln Phe Leu Leu Asn Ile Val Glu Asp Gly Leu Pro Leu 
    530                 535                 540                 


Asp Thr Thr Glu Gln Leu Pro Asp Leu Cys Val Asn Leu Leu Leu Ala 
545                 550                 555                 560 


Leu Asn Leu His Leu Pro Ala Ala Asp Gln Asn Val Ile Met Ala Ala 
                565                 570                 575     


Leu Ser Lys His Ala Asn Val Lys Ile Phe Ser Glu Lys Leu Leu Leu 
            580                 585                 590         


Leu Leu Asn Arg Gly Asp Asp Pro Val Arg Ile Phe Lys His Glu Pro 
        595                 600                 605             


Gln Pro Pro His Ser Val Leu Lys Phe Leu Gln Asp Val Phe Gly Ser 
    610                 615                 620                 


Pro Ala Thr Ala Ala Ile Phe Tyr His Thr Asp Met Met Ala Leu Ile 
625                 630                 635                 640 


Asp Ile Thr Val Arg His Ile Ala Asp Leu Ser Pro Gly Asp Lys Leu 
                645                 650                 655     


Arg Met Glu Tyr Leu Ser Leu Met His Ala Ile Val Arg Thr Thr Pro 
            660                 665                 670         


Tyr Leu Gln His Arg His Arg Leu Pro Asp Leu Gln Ala Ile Leu Arg 
        675                 680                 685             


Arg Ile Leu Asn Glu Glu Glu Thr Ser Pro Gln Cys Gln Met Asp Arg 
    690                 695                 700                 


Met Ile Val Arg Glu Met Cys Lys Glu Phe Leu Val Leu Gly Glu Ala 
705                 710                 715                 720 


Pro Ser 
        


<210> 11
<211> 715
<212> PRT
<213> Homo sapiens

<400> 11
Met Tyr Arg Ala Leu Tyr Ala Phe Arg Ser Ala Glu Pro Asn Ala Leu 
1               5                   10                  15      


Ala Phe Ala Ala Gly Glu Thr Phe Leu Val Leu Glu Arg Ser Ser Ala 
            20                  25                  30          


His Trp Trp Leu Ala Ala Arg Ala Arg Ser Gly Glu Thr Gly Tyr Val 
        35                  40                  45              


Pro Pro Ala Tyr Leu Arg Arg Leu Gln Gly Leu Glu Gln Asp Val Leu 
    50                  55                  60                  


Gln Ala Ile Asp Arg Ala Ile Glu Ala Val His Asn Thr Ala Met Arg 
65                  70                  75                  80  


Asp Gly Gly Lys Tyr Ser Leu Glu Gln Arg Gly Val Leu Gln Lys Leu 
                85                  90                  95      


Ile His His Arg Lys Glu Thr Leu Ser Arg Arg Gly Pro Ser Ala Ser 
            100                 105                 110         


Ser Val Ala Val Met Thr Ser Ser Thr Ser Asp His His Leu Asp Ala 
        115                 120                 125             


Ala Ala Ala Arg Gln Pro Asn Gly Val Cys Arg Ala Gly Phe Glu Arg 
    130                 135                 140                 


Gln His Ser Leu Pro Ser Ser Glu His Leu Gly Ala Asp Gly Gly Leu 
145                 150                 155                 160 


Tyr Gln Ile Pro Pro Gln Pro Arg Arg Ala Ala Pro Thr Thr Pro Pro 
                165                 170                 175     


Pro Pro Val Lys Arg Arg Asp Arg Glu Ala Leu Met Ala Ser Gly Ser 
            180                 185                 190         


Gly Gly His Asn Thr Met Pro Ser Gly Gly Asn Ser Val Ser Ser Gly 
        195                 200                 205             


Ser Ser Val Ser Ser Thr Ser Leu Asp Thr Leu Tyr Thr Ser Ser Ser 
    210                 215                 220                 


Pro Ser Glu Pro Gly Ser Ser Cys Ser Pro Thr Pro Pro Pro Val Pro 
225                 230                 235                 240 


Arg Arg Gly Thr His Thr Thr Val Ser Gln Val Gln Pro Pro Pro Ser 
                245                 250                 255     


Lys Ala Ser Ala Pro Glu Pro Pro Ala Glu Glu Glu Val Ala Thr Gly 
            260                 265                 270         


Thr Thr Ser Ala Ser Asp Asp Leu Glu Ala Leu Gly Thr Leu Ser Leu 
        275                 280                 285             


Gly Thr Thr Glu Glu Lys Ala Ala Ala Glu Ala Ala Val Pro Arg Thr 
    290                 295                 300                 


Ile Gly Ala Glu Leu Met Glu Leu Val Arg Arg Asn Thr Gly Leu Ser 
305                 310                 315                 320 


His Glu Leu Cys Arg Val Ala Ile Gly Ile Ile Val Gly His Ile Gln 
                325                 330                 335     


Ala Ser Val Pro Ala Ser Ser Pro Val Met Glu Gln Val Leu Leu Ser 
            340                 345                 350         


Leu Val Glu Gly Lys Asp Leu Ser Met Ala Leu Pro Ser Gly Gln Val 
        355                 360                 365             


Cys His Asp Gln Gln Arg Leu Glu Val Ile Phe Ala Asp Leu Ala Arg 
    370                 375                 380                 


Arg Lys Asp Asp Ala Gln Gln Arg Ser Trp Ala Leu Tyr Glu Asp Glu 
385                 390                 395                 400 


Gly Val Ile Arg Cys Tyr Leu Glu Glu Leu Leu His Ile Leu Thr Asp 
                405                 410                 415     


Ala Asp Pro Glu Val Cys Lys Lys Met Cys Lys Arg Asn Glu Phe Glu 
            420                 425                 430         


Ser Val Leu Ala Leu Val Ala Tyr Tyr Gln Met Glu His Arg Ala Ser 
        435                 440                 445             


Leu Arg Leu Leu Leu Leu Lys Cys Phe Gly Ala Met Cys Ser Leu Asp 
    450                 455                 460                 


Ala Ala Ile Ile Ser Thr Leu Val Ser Ser Val Leu Pro Val Glu Leu 
465                 470                 475                 480 


Ala Arg Asp Met Gln Thr Asp Thr Gln Asp His Gln Lys Leu Cys Tyr 
                485                 490                 495     


Ser Ala Leu Ile Leu Ala Met Val Phe Ser Met Gly Glu Ala Val Pro 
            500                 505                 510         


Tyr Ala His Tyr Glu His Leu Gly Thr Pro Phe Ala Gln Phe Leu Leu 
        515                 520                 525             


Asn Ile Val Glu Asp Gly Leu Pro Leu Asp Thr Thr Glu Gln Leu Pro 
    530                 535                 540                 


Asp Leu Cys Val Asn Leu Leu Leu Ala Leu Asn Leu His Leu Pro Ala 
545                 550                 555                 560 


Ala Asp Gln Asn Val Ile Met Ala Ala Leu Ser Lys His Ala Asn Val 
                565                 570                 575     


Lys Ile Phe Ser Glu Lys Leu Leu Leu Leu Leu Asn Arg Gly Asp Asp 
            580                 585                 590         


Pro Val Arg Ile Phe Lys His Glu Pro Gln Pro Pro His Ser Val Leu 
        595                 600                 605             


Lys Phe Leu Gln Asp Val Phe Gly Ser Pro Ala Thr Ala Ala Ile Phe 
    610                 615                 620                 


Tyr His Thr Asp Met Met Ala Leu Ile Asp Ile Thr Val Arg His Ile 
625                 630                 635                 640 


Ala Asp Leu Ser Pro Gly Asp Lys Leu Arg Met Glu Tyr Leu Ser Leu 
                645                 650                 655     


Met His Ala Ile Val Arg Thr Thr Pro Tyr Leu Gln His Arg His Arg 
            660                 665                 670         


Leu Pro Asp Leu Gln Ala Ile Leu Arg Arg Ile Leu Asn Glu Glu Glu 
        675                 680                 685             


Thr Ser Pro Gln Cys Gln Met Asp Arg Met Ile Val Arg Glu Met Cys 
    690                 695                 700                 


Lys Glu Phe Leu Val Leu Gly Glu Ala Pro Ser 
705                 710                 715 


<210> 12
<211> 3885
<212> DNA
<213> Homo sapiens

<400> 12
aggccggggc ggggctggga agtagtcggg cggggttgtg agacgccgcg ctcagcttcc       60

atcgctgggc ggtcaacaag tgcgggcctg gctcagcgcg ggggggcgcg gagaccgcga      120

ggcgaccggg agcggctggg ttcccggctg cgcgcccttc ggccaggccg ggagccgcgc      180

cagtcggagc ccccggccca gcgtggtccg cctccctctc ggcgtccacc tgcccggagt      240

actgccagcg ggcatgaccg acccaccagg ggcgccgccg ccggcgctcg caggccgcgg      300

atgaagaaga aaacccggcg ccgctcgacc cggagcgagg agttgacccg gagcgaggag      360

ttgaccctga gtgaggaagc gacctggagt gaagaggcga cccagagtga ggaggcgacc      420

cagggcgaag agatgaatcg gagccaggag gtgacccggg acgaggagtc gacccggagc      480

gaggaggtga ccagggagga aatggcggca gctgggctca ccgtgactgt cacccacagc      540

aatgagaagc acgaccttca tgttacctcc cagcagggca gcagtgaacc agttgtccaa      600

gacctggccc aggttgttga agaggtcata ggggttccac agtcttttca gaaactcata      660

tttaagggaa aatctctgaa ggaaatggaa acaccgttgt cagcacttgg aatacaagat      720

ggttgccggg tcatgttaat tgggaaaaag aacagtccac aggaagaggt tgaactaaag      780

aagttgaaac atttggagaa gtctgtggag aagatagctg accagctgga agagttgaat      840

aaagagctta ctggaatcca gcagggtttt ctgcccaagg atttgcaagc tgaagctctc      900

tgcaaacttg ataggagagt aaaagccaca atagagcagt ttatgaagat cttggaggag      960

attgacacac tgatcctgcc agaaaatttc aaagacagta gattgaaaag gaaaggcttg     1020

gtaaaaaagg ttcaggcatt cctagccgag tgtgacacag tggagcagaa catctgccag     1080

gagactgagc ggctgcagtc tacaaacttt gccctggccg agtgaggtgt agcagaaaaa     1140

ggctgtgctg ccctgaagaa tggcgccacc agctctgccg tctctggagc ggaatttacc     1200

tgatttcttc agggctgctg ggggcaactg gccatttgcc aattttccta ctctcacact     1260

ggttctcaat gaaaaatagt gtctttgtga ttttgagtaa agctcctatc tgttttctcc     1320

ttctgtctct gtggttgtac tgtccagcaa tccacctttt ctggagaggg ccacctctgc     1380

ccaaattttc ccagctgttt ggacctctgg gtgctttctt tgggctggtg agagctctaa     1440

tttgccttgg gccagtttca ggtttatagg ccccctcagt cttcagatac atgagggctt     1500

ctttgctctt gtgatcgtgt agtcccatag ctgtaaaacc agaatcacca ggaggttgca     1560

cctagtcagg aatattggga atggcctaga acaaggtgtt tggcacataa gtagaccact     1620

tatccctcat tgtgacctaa ttccagagca tctggctggg ttgttgggtt ctagactttg     1680

tcctcacctc ccagtgaccc tgactagcca caggccatga gataccaggg ggccgttcct     1740

tggatggagc ctgtggttga tgcaaggctt ccttgtcccc aagcaagtct tcagaaggtt     1800

agaacccagt gttgactgag tctgtgcttg aaaccaggcc agagccatgg attaggaagg     1860

gcaaagagaa ggcaccagaa tgagtaaagc aggcaggtgg tgaagccaac cataaacttc     1920

tcaggagtga catgtgcttc cttcaaaggc atttttgtta accatatcct tctgagttct     1980

atgtttcctt cacagctgtt ctatccattt tgtggactgt cccccacccc caccccatca     2040

ttgtttttaa aaaattaagg cctggcgcag cagctcatgc ctataatccc agcactttgg     2100

gaggctgagg cgggcggatc acttgaggcc aggagtttga gaccagccca ggcaacatag     2160

caaaacccca ttctgcttta aaaaaaaaaa aaaaaaaaat tagcttggcg tagtggcatg     2220

tgcctataat cccagctact ggggaggctg aggcacaaga atcatttgaa cctgggaggt     2280

agaggttgct gtgagccgag attacgcccc tgcactccag cctgggtcac agagtgagac     2340

tccatctcag aaaaaaaaaa aattgagtca ggtgcagtag ctccttcctg tagtcccagc     2400

tacttgggag gctgaggcta gaggatcact tgagcccagg agtttgagtc tagtctgggc     2460

aacatagcaa gaccccatct ctaaaattta agtaagtaaa agtagataaa taaaaagaaa     2520

aaaaaactgt ttatgtgctc atcataaagt agaagagtgg tttgcttttt tttttttttt     2580

tggattaatg aggaaatcat tctgtggctc tagtcataat ttatgcttaa taacattgat     2640

agtagccctt tgcgctataa ctctacctaa agactcacat catttggcag agagagagtc     2700

gttgaagtcc caggaattca ggactgggca ggttaagacc tcagacaagg tagtagaggt     2760

agacttgtgg acaaggctcg ggtcccagcc caccgcaccc caactttaat cagagtggtt     2820

cactattgat ctatttttgt gtgatagctg tgtggcgtgg gccacaacat ttaatgagaa     2880

gttactgtgc accaaactgc cgaacaccat tctaaactat tcatatatat tagtcattta     2940

attcttacat aacttgagag gtagacagat atccttattt tagagatgag gaaaccaaga     3000

gaacttaggt cattagcgca aggttgtaga gtaagcggca aagccaagac acaaagctgg     3060

gtggtttggt ttcagagcca gtgcttttcc cctctactgt actgcctctc aaccaacaca     3120

gggttgcaca ggcccattct ctgatttttt tcctcttgtc ctctgcctct ccctctagct     3180

cccacttcct ctctgctcta gttcattttc tttagagcag cccgagtgat catgaagtgc     3240

aaatcttgcc atgtcagtcc cctgcttaga accctccaat ggctcacttt ctctttaggc     3300

aaaagtcttt accccatgcc ttctcccatc tcatctcaac cccctcattt gttggctgtc     3360

tgctgtcagc cactcttctt tcaggtcctc agatgcactg caccctctcc tgcctggggg     3420

tctttgctcc tgctactacc tctgcttgaa cagctcctca ccttccttcc tccaacccta     3480

cccttgtata ggtgactttt gttcatcctt cagaattcaa ctcacatgtc tcttgcatgg     3540

agaaccctca cctactgtgt tgagaccctg tccagccccc aggtgggatc ctctctcgac     3600

ttcccataca tttctttcac agcatttaca tagtccatga tagtttactt gtgggattat     3660

ttggttaatc tttgccttta acaccagggt tccttgggtg aaggagcttc tttatcttgg     3720

taacagcatt atttcaagca taacttgtaa tatagttata ttacatatat aacatatata     3780

tatataacat aacatatata acatatataa caagcataac ttgttatata gtcttgtata     3840

tagtaagacc tcaataaata tttggagaac aaaaaaaaaa aaaaa                     3885


<210> 13
<211> 230
<212> PRT
<213> Homo sapiens

<400> 13
Met Asn Arg Ser Gln Glu Val Thr Arg Asp Glu Glu Ser Thr Arg Ser 
1               5                   10                  15      


Glu Glu Val Thr Arg Glu Glu Met Ala Ala Ala Gly Leu Thr Val Thr 
            20                  25                  30          


Val Thr His Ser Asn Glu Lys His Asp Leu His Val Thr Ser Gln Gln 
        35                  40                  45              


Gly Ser Ser Glu Pro Val Val Gln Asp Leu Ala Gln Val Val Glu Glu 
    50                  55                  60                  


Val Ile Gly Val Pro Gln Ser Phe Gln Lys Leu Ile Phe Lys Gly Lys 
65                  70                  75                  80  


Ser Leu Lys Glu Met Glu Thr Pro Leu Ser Ala Leu Gly Ile Gln Asp 
                85                  90                  95      


Gly Cys Arg Val Met Leu Ile Gly Lys Lys Asn Ser Pro Gln Glu Glu 
            100                 105                 110         


Val Glu Leu Lys Lys Leu Lys His Leu Glu Lys Ser Val Glu Lys Ile 
        115                 120                 125             


Ala Asp Gln Leu Glu Glu Leu Asn Lys Glu Leu Thr Gly Ile Gln Gln 
    130                 135                 140                 


Gly Phe Leu Pro Lys Asp Leu Gln Ala Glu Ala Leu Cys Lys Leu Asp 
145                 150                 155                 160 


Arg Arg Val Lys Ala Thr Ile Glu Gln Phe Met Lys Ile Leu Glu Glu 
                165                 170                 175     


Ile Asp Thr Leu Ile Leu Pro Glu Asn Phe Lys Asp Ser Arg Leu Lys 
            180                 185                 190         


Arg Lys Gly Leu Val Lys Lys Val Gln Ala Phe Leu Ala Glu Cys Asp 
        195                 200                 205             


Thr Val Glu Gln Asn Ile Cys Gln Glu Thr Glu Arg Leu Gln Ser Thr 
    210                 215                 220                 


Asn Phe Ala Leu Ala Glu 
225                 230 


<210> 14
<211> 4468
<212> DNA
<213> Homo sapiens

<400> 14
agcaaatcag atatgcccaa aacgttacag aggtaacagt gaatccagga tgctgctgtc       60

agcctgtgca ttgtgaagaa ggcaatcata ggcgagcagc cgcgggagca ggaacagcag      120

cgtgctaaga agcagtcaca taaacagcag caggagtagg cctcctgctt ttcaaaagca      180

gagtactgca gggtcgcgaa atgcaagaca ctcagatgtt tgaaaatctc ccgagttgag      240

aatggctact gtaaaagcgt caccaagaaa ctctgacgat ctggacagtc ctaactctgt      300

gttagcaata cttacttccg gaaaattaat gctacttctt gtagattttt gcaaatagga      360

aacccccttg aagaagatct caaattacgc cccccacccc caaaaaaaga caaacagggg      420

agaacaaagt tttggcatgc ctgcaggaac ggtggctttt ttagaaacta cctaggaggc      480

agaagctaag tgatttgctc atgcctctta cctgggagta gaaggtggga agaaatggac      540

cgaggctgtg acgagaagac aaggcacagt gcagcttggt gaagccacac gctgactgcg      600

ttctgccccc tcttcatgca gtgctgcggg ctggtgcatc gccggcgagt acgggtgtcc      660

tatggttcgg cagactccta cactagccgt ccatccgatt ccgatgtatc tctggaggag      720

gaccgggagg cagtgcgcag agaagcggag cggcaggccc aggcacagtt ggaaaaagca      780

aagacaaagc ccgttgcatt tgcggttcgg acaaatgtca gctacagtgc ggcccatgaa      840

gatgatgttc cagtgcctgg catggccatc tcattcgaag caaaagattt tctgcatgtt      900

aaggaaaaat ttaacaatga ctggtggata gggcgattgg taaaagaagg ctgtgaaatc      960

ggattcattc caagcccagt caaactagaa aacatgaggc tgcagcatga acagagagcc     1020

aagcaaggga aattctactc cagtaaatca ggaggaaatt catcatccag tttgggtgac     1080

atagtaccta gttccagaaa atcaacacct ccatcatctg ctatagacat agatgctact     1140

ggcttagatg cagaagaaaa tgatattcca gcaaaccacc gctcccctaa acccagtgca     1200

aacagtgtaa cgtcacccca ctccaaagag aaaagaatgc ccttctttaa gaagacagag     1260

cacactcctc cgtatgatgt ggtaccttcc atgcgaccag tggtcctagt gggcccttct     1320

ctgaagggct acgaggtcac agatatgatg caaaaagcgc tgtttgattt tttaaaacac     1380

agatttgaag ggcggatatc catcacaagg gtcaccgctg acatctcgct tgccaaacgc     1440

tcggtattaa acaatcccag taagcacgca ataatagaaa gatccaacac aaggtcaagc     1500

ttagcggaag ttcagagtga aatcgaaagg atttttgaac ttgcaagaac attgcagttg     1560

gtggtccttg acgcggatac aattaatcat ccagctcaac tcagtaaaac ctccttggcc     1620

cctattatag tatatgtaaa gatttcttct cctaaggttt tacaaaggtt aataaaatct     1680

cgagggaaat ctcaagctaa acacctcaac gtccagatgg tagcagctga taaactggct     1740

cagtgtcctc cagagctgtt cgatgtgatc ttggatgaga accagcttga ggatgcctgt     1800

gagcaccttg ccgactatct ggaggcctac tggaaggcca cccatcctcc cagcagtagc     1860

ctccccaacc ctctccttag ccgtacatta gccacttcaa gtctgcctct tagccccacc     1920

ctagcctcta attcacaggg ttctcaaggt gatcagagga ctgatcgctc cgctcctatc     1980

cgttctgctt cccaagctga agaagaacct agtgtggaac cagtcaagaa atcccagcac     2040

cgctcttcct cctcagcccc acaccacaac catcgcagtg ggacaagtcg cggcctctcc     2100

aggcaagaga catttgactc ggaaacccag gagagtcgag actctgccta cgtagagcca     2160

aaggaagatt attcccatga ccacgtggac cactatgcct cacaccgtga ccacaaccac     2220

agagacgaga cccacgggag cagtgaccac agacacaggg agtcccggca ccgttcccgg     2280

gacgtggatc gagagcagga ccacaacgag tgcaacaagc agcgcagccg tcataaatcc     2340

aaggatcgct actgtgaaaa ggatggagaa gtgatatcaa aaaaacggaa tgaggctggg     2400

gagtggaaca gggatgttta catccgccaa tgagttttgc ccgtttgtgt tttttttttt     2460

ttttttttga agtcttgtat aactaacagc atccccaaaa caaagtcttt ggggtctaca     2520

ctgcaatcat atgtgatctg tcttgtaata ttttgtatta ttgctgttgc ttgaatagca     2580

atagcatgga tagagtattg agatactttt tcttttgtaa gtgctacata aattggcctg     2640

gtatggctgc agtcctccgg ttgcatactg gactcttcaa aaactgtttt gggtagctgc     2700

cacttgaaca aaatctgttg ccacccaggt gatgttagtg ttttaagaaa tgtagttgat     2760

gtatccaaca agccagaatc agcacagata aaaagtggaa tttcttgttt ctccagattt     2820

ttaatacgtt aatacgcagg catctgattt gcatattcat tcatggacca ctgtttcttg     2880

cttgtacctc tggctgacta aatttgggga cagattcagt cttgccttac acaaagggga     2940

tcataaagtt agaatctatt ttctatgtac tagtactgtg tactgtatag acagtttgta     3000

aatgttattt ctgcaaacaa acaccttctt attatatata taatatatat atatatcagt     3060

ttgatcacac tattttagag tcttaatgcc aagtcagcag atttgcttta tgaattacag     3120

ggactagaaa tgcccacatt caggaaattt gtaataacat tgtctagaca cctatcctca     3180

ttctagtaga aagtgtgtac atactgtaaa tatgtgtgat tgcttgactt gaaaaggttt     3240

gaattctgaa tgttatacca tccttgtaag taagtttgta atttccacca taaattatgg     3300

taaatataaa actccagagg ttgttctact ccatacagtt cacactgatt gtgacacatt     3360

cttagtagct agtgtctgtt ctagtcactg cactggagtc tacgagccgg aactcgctat     3420

atgcacgtgt gtgtgtccgt atgtaagaaa gtgtgcaccg agtgactgaa tggttgagat     3480

gaattggaat gctgaagact aacgaagaaa ctagagactg atatcgagca ttctgcccac     3540

ctcgctctgt atttaattaa ttgtgctata tgttgcttta acaacccatt gagcagtcag     3600

ggaatgtgag taagcttgct gccaaaggta actaggaaag cattcatctg ctgcctcctt     3660

gtttttgctc ctagagagtg aaaatacagg caattttact gtgagtgttt cactggaaat     3720

gtacaatctt tgtgtgttag agtatttgtt ttagtaagaa atgtttacac agcttgtgga     3780

attatttcgt gggaaaataa atttttataa cttctcccac ttcaatttct aaccttgcct     3840

attgttcctg ttgtttgttt acctcccagt tacctaccat tcctccccac caccgactcc     3900

agcaggttca ctgtctgtca gaacccagaa gtgcttctta taaccaaagt ttctgttctt     3960

cagaagaaat cagggcaaaa tggggtgact tgaagtgaat aaaatgttaa gaatattatc     4020

ctacataaga catgtacaca gaaggggaac cttgaagaca ttatctccat gcctcaatta     4080

cactgctgta agaagcttac aatgtcatca tgtttaaggc taagaccttt tccgtgtctc     4140

aagtgtatat tttgtccagt tataactgga tggtaagaca gtattaagag tgcaagtacc     4200

tggcacttga agtttgtccc aggaaaatgc ctgtgtataa ttacctaact tcagatctgc     4260

acattaactt atttaacaaa ataaatcagc cgggcgcagt ggctcatgcc tgtaatccca     4320

gcaatttggg aggctgagga gggtggatca cctgaggtca ggagttcaag accagcctgg     4380

ccaacgtggc gaaaccccgt ctctactaaa aagataaaaa attagccagg tgtggtggtg     4440

cacacctgta atcccagcta cttgggag                                        4468


<210> 15
<211> 605
<212> PRT
<213> Homo sapiens

<400> 15
Met Gln Cys Cys Gly Leu Val His Arg Arg Arg Val Arg Val Ser Tyr 
1               5                   10                  15      


Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ala Val Arg Arg Glu Ala Glu Arg Gln Ala 
        35                  40                  45              


Gln Ala Gln Leu Glu Lys Ala Lys Thr Lys Pro Val Ala Phe Ala Val 
    50                  55                  60                  


Arg Thr Asn Val Ser Tyr Ser Ala Ala His Glu Asp Asp Val Pro Val 
65                  70                  75                  80  


Pro Gly Met Ala Ile Ser Phe Glu Ala Lys Asp Phe Leu His Val Lys 
                85                  90                  95      


Glu Lys Phe Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly 
            100                 105                 110         


Cys Glu Ile Gly Phe Ile Pro Ser Pro Val Lys Leu Glu Asn Met Arg 
        115                 120                 125             


Leu Gln His Glu Gln Arg Ala Lys Gln Gly Lys Phe Tyr Ser Ser Lys 
    130                 135                 140                 


Ser Gly Gly Asn Ser Ser Ser Ser Leu Gly Asp Ile Val Pro Ser Ser 
145                 150                 155                 160 


Arg Lys Ser Thr Pro Pro Ser Ser Ala Ile Asp Ile Asp Ala Thr Gly 
                165                 170                 175     


Leu Asp Ala Glu Glu Asn Asp Ile Pro Ala Asn His Arg Ser Pro Lys 
            180                 185                 190         


Pro Ser Ala Asn Ser Val Thr Ser Pro His Ser Lys Glu Lys Arg Met 
        195                 200                 205             


Pro Phe Phe Lys Lys Thr Glu His Thr Pro Pro Tyr Asp Val Val Pro 
    210                 215                 220                 


Ser Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu 
225                 230                 235                 240 


Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg 
                245                 250                 255     


Phe Glu Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Ile Ser Leu 
            260                 265                 270         


Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ala Ile Ile Glu 
        275                 280                 285             


Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser Glu Ile Glu 
    290                 295                 300                 


Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Val Leu Asp Ala 
305                 310                 315                 320 


Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser Leu Ala Pro 
                325                 330                 335     


Ile Ile Val Tyr Val Lys Ile Ser Ser Pro Lys Val Leu Gln Arg Leu 
            340                 345                 350         


Ile Lys Ser Arg Gly Lys Ser Gln Ala Lys His Leu Asn Val Gln Met 
        355                 360                 365             


Val Ala Ala Asp Lys Leu Ala Gln Cys Pro Pro Glu Leu Phe Asp Val 
    370                 375                 380                 


Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Asp 
385                 390                 395                 400 


Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser Ser Leu 
                405                 410                 415     


Pro Asn Pro Leu Leu Ser Arg Thr Leu Ala Thr Ser Ser Leu Pro Leu 
            420                 425                 430         


Ser Pro Thr Leu Ala Ser Asn Ser Gln Gly Ser Gln Gly Asp Gln Arg 
        435                 440                 445             


Thr Asp Arg Ser Ala Pro Ile Arg Ser Ala Ser Gln Ala Glu Glu Glu 
    450                 455                 460                 


Pro Ser Val Glu Pro Val Lys Lys Ser Gln His Arg Ser Ser Ser Ser 
465                 470                 475                 480 


Ala Pro His His Asn His Arg Ser Gly Thr Ser Arg Gly Leu Ser Arg 
                485                 490                 495     


Gln Glu Thr Phe Asp Ser Glu Thr Gln Glu Ser Arg Asp Ser Ala Tyr 
            500                 505                 510         


Val Glu Pro Lys Glu Asp Tyr Ser His Asp His Val Asp His Tyr Ala 
        515                 520                 525             


Ser His Arg Asp His Asn His Arg Asp Glu Thr His Gly Ser Ser Asp 
    530                 535                 540                 


His Arg His Arg Glu Ser Arg His Arg Ser Arg Asp Val Asp Arg Glu 
545                 550                 555                 560 


Gln Asp His Asn Glu Cys Asn Lys Gln Arg Ser Arg His Lys Ser Lys 
                565                 570                 575     


Asp Arg Tyr Cys Glu Lys Asp Gly Glu Val Ile Ser Lys Lys Arg Asn 
            580                 585                 590         


Glu Ala Gly Glu Trp Asn Arg Asp Val Tyr Ile Arg Gln 
        595                 600                 605 


<210> 16
<211> 22
<212> PRT
<213> Homo sapiens

<400> 16
Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser 
            20          


<210> 17
<211> 105
<212> PRT
<213> Homo sapiens

<400> 17
Pro Asn Leu Leu Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys 
1               5                   10                  15      


Gln Val Asp Gln Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr 
            20                  25                  30          


Lys Asp Gly Ala Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu 
        35                  40                  45              


Ser Leu Gly Val Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro 
    50                  55                  60                  


Ser His Leu Thr Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly 
65                  70                  75                  80  


Ala Tyr Val Cys Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala 
                85                  90                  95      


Glu Gly Asn Ile Thr Arg Leu Phe Val 
            100                 105 


<210> 18
<211> 110
<212> PRT
<213> Homo sapiens

<400> 18
Trp Gly Arg Arg Ser Cys Gln Gln Arg Asp Ser Gly Asn Ser Pro Gly 
1               5                   10                  15      


Asn Ala Phe Tyr Ser Asn Val Leu Tyr Arg Pro Arg Gly Pro Pro Lys 
            20                  25                  30          


Lys Ser Glu Asp Cys Ser Gly Glu Gly Lys Asp Gln Arg Gly Gln Ser 
        35                  40                  45              


Ile Tyr Ser Thr Ser Phe Pro Gln Pro Ala Pro Arg Gln Pro His Leu 
    50                  55                  60                  


Ala Ser Arg Pro Cys Pro Ser Pro Arg Pro Cys Pro Ser Pro Arg Pro 
65                  70                  75                  80  


Gly His Pro Val Ser Met Val Arg Val Ser Pro Arg Pro Ser Pro Thr 
                85                  90                  95      


Gln Gln Pro Arg Pro Lys Gly Phe Pro Lys Val Gly Glu Glu 
            100                 105                 110 


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Gly Gly Gly Gly Cys 
1               5   


<210> 20
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 20
cagcaaaggg acucagguau u                                                 21


<210> 21
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
agguaacagc ccaggaaauu u                                                 21


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 22
ctgagttgga ggaggctgag                                                   20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 23
cgatccggtt tctgttctgt                                                   20


<210> 24
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (3)..(31)
<223> a, c, t, g, unknown or other

<400> 24
aannnnnnnn nnnnnnnnnn nnnnnnnnnn ntt                                    33


