                         SEQUENCE LISTING

<110>  Gevo, Inc.
       Meinhold, Peter
       Peters, Matthew W.
       Hawkins, Andrew C.
       Feldman, Reid M.
       Urano, Jun
 
<120>  TUNING OF FUSEL ALCOHOL BY-PRODUCTS DURING ISOBUTANOL PRODUCTION 
       BY RECOMBINANT MICROORGANISMS

<130>  GEVO-058/01WO

<150>  US 61/502,171
<151>  2011-06-28

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  1860
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  1
atggttaaag agagtattat tgctcttgct gagcatgcgg cctccagagc ctcaagagtt       60

attcctccag tgaagctagc ctataaaaat atgcttaagg acccttcctc caagtacaag      120

ccatttaacg ctccaaagct atctaataga aagtggccgg ataaccggat cacgagggct      180

cctcgttggt tatcaacaga tttgagagat ggtaaccaat ctctgccgga tcccatgtca      240

gtggaacaaa agaaagaata ctttcacaag ctggtcaata ttgggttcaa agaaatcgag      300

gtttccttcc cctctgcatc tcaaacagat ttcgacttca ctagatatgc tgtagaaaac      360

gccccagacg atgttagtat tcaatgtctt gtccaatcta gagaacactt gattaagaga      420

acggtggaag cattaacagg tgctaaaaag gctactatac atacttactt ggcaacaagt      480

gatatgttcc gtgaaattgt ttttaatatg tctagagagg aagctatttc caaggcagta      540

gaggccacca aactagttag gaaactaact aaggatgacc cttcccaaca agccactcgt      600

tggtcctatg agttttcccc cgaatgtttc agtgatactc caggtgaatt tgctgtagaa      660

atttgcgaag ctgttaagaa ggcttgggaa cctaccgagg aaaatccaat cattttcaac      720

ttacctgcta ccgtagaagt tgcctctcca aatgtttatg ctgatcagat tgaatacttc      780

gctacccata ttactgagcg tgagaaggtt tgcatctcta cacattgtca caatgaccgt      840

ggttgcggtg tcgccgccac agagttaggt atgcttgcag gtgccgaccg tgtagaagga      900

tgtctctttg gtaatggtga acgtacaggt aatgtggact tggttactgt tgctatgaat      960

atgtataccc aaggtgtttc tcctaatttg gatttctctg acttgacctc tgtcctagat     1020

gtggttgagc gttgtaataa gatcccagta tcgcaaagag caccatacgg cggtgacttg     1080

gtcgtttgtg ccttttccgg ttctcaccaa gacgccatta agaagggttt caacttacaa     1140

aacaagaagc gtgctcaagg tgaaactcaa tggagaatcc catacttgcc attggatcca     1200

aaggacattg gccgtgatta cgaagctgtc atcagagtca actctcagtc tggtaaaggt     1260

ggtgccgctt gggttatttt gagatctttg ggtttggatc taccaagaaa catgcaaatc     1320

gaattttcta gcgccgttca agaccatgct gactccttgg gtagagaact aaaatcagat     1380

gagatttcca agttattcaa agaggcttac aactacaatg acgaacagta ccaagctatt     1440

agtttagtca attataatgt tgaaaaattc ggcactgaac gtagagtgtt cactggtcaa     1500

gtcaaagtag gcgaccagat cgtcgatatt gaaggtacag gtaatggtcc aatctcttct     1560

ttggtcgacg ccctatcaaa cttgttgaac gtgagatttg ccgtagcaaa ctacacagag     1620

cattctctag gttctggttc ttctacgcaa gctgcttctt acatccatct atcgtatagg     1680

cgtaatgccg acaacgaaaa ggcctacaaa tggggtgtag gtgtctccga agatgtcggt     1740

gattcttcag tgagagccat ctttgccacc attaacaata ttatccattc tggtgatgtg     1800

tccattccat ctttggccga ggtcgaaggt aagaatgctg cggcatctgg ctctgcataa     1860


<210>  2
<211>  619
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Val Lys Glu Ser Ile Ile Ala Leu Ala Glu His Ala Ala Ser Arg 
1               5                   10                  15      


Ala Ser Arg Val Ile Pro Pro Val Lys Leu Ala Tyr Lys Asn Met Leu 
            20                  25                  30          


Lys Asp Pro Ser Ser Lys Tyr Lys Pro Phe Asn Ala Pro Lys Leu Ser 
        35                  40                  45              


Asn Arg Lys Trp Pro Asp Asn Arg Ile Thr Arg Ala Pro Arg Trp Leu 
    50                  55                  60                  


Ser Thr Asp Leu Arg Asp Gly Asn Gln Ser Leu Pro Asp Pro Met Ser 
65                  70                  75                  80  


Val Glu Gln Lys Lys Glu Tyr Phe His Lys Leu Val Asn Ile Gly Phe 
                85                  90                  95      


Lys Glu Ile Glu Val Ser Phe Pro Ser Ala Ser Gln Thr Asp Phe Asp 
            100                 105                 110         


Phe Thr Arg Tyr Ala Val Glu Asn Ala Pro Asp Asp Val Ser Ile Gln 
        115                 120                 125             


Cys Leu Val Gln Ser Arg Glu His Leu Ile Lys Arg Thr Val Glu Ala 
    130                 135                 140                 


Leu Thr Gly Ala Lys Lys Ala Thr Ile His Thr Tyr Leu Ala Thr Ser 
145                 150                 155                 160 


Asp Met Phe Arg Glu Ile Val Phe Asn Met Ser Arg Glu Glu Ala Ile 
                165                 170                 175     


Ser Lys Ala Val Glu Ala Thr Lys Leu Val Arg Lys Leu Thr Lys Asp 
            180                 185                 190         


Asp Pro Ser Gln Gln Ala Thr Arg Trp Ser Tyr Glu Phe Ser Pro Glu 
        195                 200                 205             


Cys Phe Ser Asp Thr Pro Gly Glu Phe Ala Val Glu Ile Cys Glu Ala 
    210                 215                 220                 


Val Lys Lys Ala Trp Glu Pro Thr Glu Glu Asn Pro Ile Ile Phe Asn 
225                 230                 235                 240 


Leu Pro Ala Thr Val Glu Val Ala Ser Pro Asn Val Tyr Ala Asp Gln 
                245                 250                 255     


Ile Glu Tyr Phe Ala Thr His Ile Thr Glu Arg Glu Lys Val Cys Ile 
            260                 265                 270         


Ser Thr His Cys His Asn Asp Arg Gly Cys Gly Val Ala Ala Thr Glu 
        275                 280                 285             


Leu Gly Met Leu Ala Gly Ala Asp Arg Val Glu Gly Cys Leu Phe Gly 
    290                 295                 300                 


Asn Gly Glu Arg Thr Gly Asn Val Asp Leu Val Thr Val Ala Met Asn 
305                 310                 315                 320 


Met Tyr Thr Gln Gly Val Ser Pro Asn Leu Asp Phe Ser Asp Leu Thr 
                325                 330                 335     


Ser Val Leu Asp Val Val Glu Arg Cys Asn Lys Ile Pro Val Ser Gln 
            340                 345                 350         


Arg Ala Pro Tyr Gly Gly Asp Leu Val Val Cys Ala Phe Ser Gly Ser 
        355                 360                 365             


His Gln Asp Ala Ile Lys Lys Gly Phe Asn Leu Gln Asn Lys Lys Arg 
    370                 375                 380                 


Ala Gln Gly Glu Thr Gln Trp Arg Ile Pro Tyr Leu Pro Leu Asp Pro 
385                 390                 395                 400 


Lys Asp Ile Gly Arg Asp Tyr Glu Ala Val Ile Arg Val Asn Ser Gln 
                405                 410                 415     


Ser Gly Lys Gly Gly Ala Ala Trp Val Ile Leu Arg Ser Leu Gly Leu 
            420                 425                 430         


Asp Leu Pro Arg Asn Met Gln Ile Glu Phe Ser Ser Ala Val Gln Asp 
        435                 440                 445             


His Ala Asp Ser Leu Gly Arg Glu Leu Lys Ser Asp Glu Ile Ser Lys 
    450                 455                 460                 


Leu Phe Lys Glu Ala Tyr Asn Tyr Asn Asp Glu Gln Tyr Gln Ala Ile 
465                 470                 475                 480 


Ser Leu Val Asn Tyr Asn Val Glu Lys Phe Gly Thr Glu Arg Arg Val 
                485                 490                 495     


Phe Thr Gly Gln Val Lys Val Gly Asp Gln Ile Val Asp Ile Glu Gly 
            500                 505                 510         


Thr Gly Asn Gly Pro Ile Ser Ser Leu Val Asp Ala Leu Ser Asn Leu 
        515                 520                 525             


Leu Asn Val Arg Phe Ala Val Ala Asn Tyr Thr Glu His Ser Leu Gly 
    530                 535                 540                 


Ser Gly Ser Ser Thr Gln Ala Ala Ser Tyr Ile His Leu Ser Tyr Arg 
545                 550                 555                 560 


Arg Asn Ala Asp Asn Glu Lys Ala Tyr Lys Trp Gly Val Gly Val Ser 
                565                 570                 575     


Glu Asp Val Gly Asp Ser Ser Val Arg Ala Ile Phe Ala Thr Ile Asn 
            580                 585                 590         


Asn Ile Ile His Ser Gly Asp Val Ser Ile Pro Ser Leu Ala Glu Val 
        595                 600                 605             


Glu Gly Lys Asn Ala Ala Ala Ser Gly Ser Ala 
    610                 615                 


<210>  3
<211>  1815
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  3
atggtaaaac attcgttcat agcgctagct gagcatgcta gtaaactaag aaggtctatc       60

ccacccgtca aactgactta taaaaatatg ctacgggacc catcggtaaa atatagggcg      120

tttgctccac caaaaatggt caagaggatt tggcctgaca aaactattca aaaggctcca      180

cgttggctgt ctactgactt gagggacggt aatcaatctt taccggaccc aatgtctgtg      240

gctcaaaaga aagaatattt ccacaagttg atcaacatcg gtttcaaaga aatcgaagtg      300

tctttcccct ctgcatctca aacagatttc gacttcacca ggtatgctgt agaaaacgct      360

ccagatgatg ttggtattca atgtcttgtc caatctagag aacacttgat taaaagaacc      420

gtggaagcat tgactggtgc taaaagggct accatacata cttacttggc cacaagtgac      480

atgttccgag aaattgtctt caatatgtct agagaggaag ctatttctaa agctgtagaa      540

gccaccaaac tggttaggaa actaaccaag gatgaccctt cccagcaagc tactcgttgg      600

tcctatgagt tttctcccga atgtttcagt gatacgccag gtgaatttgc tgtagaaatt      660

tgtgaagctg ttaaaaaggc ttgggaacct accgaggaaa atccgatcat tttcaactta      720

ccagctactg tagaagttgc ctctccaaat gtttacgctg atcaaattga gtacttctct      780

acccacatta ctgagcgtga gaaggtctgt atttctacgc attgtcacaa tgaccgtggt      840

tgcggtgtcg ccgccacaga attaggtatg cttgcaggcg ctgatcgtgt agaaggttgt      900

ctatttggta atggtgaacg tacaggtaat gttgatttgg ttacagttgc catgaatatg      960

tatacccaag gtgtttctcc taatttagat ttctcagatt taacttcaat ttctgaaatt     1020

gtccatcgct gtaacaagat tccaattccc ccaagagccc catatggcgg tgaattggtt     1080

gtttctgcct tttctggttc tcatcaggat gcaattaaga agggatttgc aatccaaaac     1140

aagaaacagg ctcaaggaga aactcggtgg agaattccat acttaccatt ggatccaaag     1200

gatattggac gtgattacga agccgtcatc agagtcaact ctcaatccgg taagggtggt     1260

gctgcttggg ttattatgag atctctagga ttagatgtac caagaccaat gcaagttgat     1320

ttctccaata ctctacagaa aaatgcagat gccttaggaa gagagttaaa atccgaagag     1380

attacaaaat tgttcaaaga aacttacaac tacaacaaca atgaacatat atacgtcacc     1440

ttgttgaatt acgaagttaa gaaattgaac ccagagcgta gagctttagt gggccaggta     1500

gaaatcaacg ataaggttgt caacatcgaa ggctacggaa atggtcctat ctcttctttg     1560

gtggatgcgc tatccaattt actgaatgtt aagttgagcg ttcaaaacta ctctgaacat     1620

tccttgggtt ctggttctgc aacccaagcg gcatctttca taaatctttc ctacataaag     1680

gacatcaata atcatgctac tagtaatatg tggggtgttg gtgtctccga agacactggg     1740

gatgcatcta ttaaggcggt atttgctact gtcaataata ttattcattc cggggatgtt     1800

ctactggcag agtaa                                                      1815


<210>  4
<211>  604
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  4

Met Val Lys His Ser Phe Ile Ala Leu Ala Glu His Ala Ser Lys Leu 
1               5                   10                  15      


Arg Arg Ser Ile Pro Pro Val Lys Leu Thr Tyr Lys Asn Met Leu Arg 
            20                  25                  30          


Asp Pro Ser Val Lys Tyr Arg Ala Phe Ala Pro Pro Lys Met Val Lys 
        35                  40                  45              


Arg Ile Trp Pro Asp Lys Thr Ile Gln Lys Ala Pro Arg Trp Leu Ser 
    50                  55                  60                  


Thr Asp Leu Arg Asp Gly Asn Gln Ser Leu Pro Asp Pro Met Ser Val 
65                  70                  75                  80  


Ala Gln Lys Lys Glu Tyr Phe His Lys Leu Ile Asn Ile Gly Phe Lys 
                85                  90                  95      


Glu Ile Glu Val Ser Phe Pro Ser Ala Ser Gln Thr Asp Phe Asp Phe 
            100                 105                 110         


Thr Arg Tyr Ala Val Glu Asn Ala Pro Asp Asp Val Gly Ile Gln Cys 
        115                 120                 125             


Leu Val Gln Ser Arg Glu His Leu Ile Lys Arg Thr Val Glu Ala Leu 
    130                 135                 140                 


Thr Gly Ala Lys Arg Ala Thr Ile His Thr Tyr Leu Ala Thr Ser Asp 
145                 150                 155                 160 


Met Phe Arg Glu Ile Val Phe Asn Met Ser Arg Glu Glu Ala Ile Ser 
                165                 170                 175     


Lys Ala Val Glu Ala Thr Lys Leu Val Arg Lys Leu Thr Lys Asp Asp 
            180                 185                 190         


Pro Ser Gln Gln Ala Thr Arg Trp Ser Tyr Glu Phe Ser Pro Glu Cys 
        195                 200                 205             


Phe Ser Asp Thr Pro Gly Glu Phe Ala Val Glu Ile Cys Glu Ala Val 
    210                 215                 220                 


Lys Lys Ala Trp Glu Pro Thr Glu Glu Asn Pro Ile Ile Phe Asn Leu 
225                 230                 235                 240 


Pro Ala Thr Val Glu Val Ala Ser Pro Asn Val Tyr Ala Asp Gln Ile 
                245                 250                 255     


Glu Tyr Phe Ser Thr His Ile Thr Glu Arg Glu Lys Val Cys Ile Ser 
            260                 265                 270         


Thr His Cys His Asn Asp Arg Gly Cys Gly Val Ala Ala Thr Glu Leu 
        275                 280                 285             


Gly Met Leu Ala Gly Ala Asp Arg Val Glu Gly Cys Leu Phe Gly Asn 
    290                 295                 300                 


Gly Glu Arg Thr Gly Asn Val Asp Leu Val Thr Val Ala Met Asn Met 
305                 310                 315                 320 


Tyr Thr Gln Gly Val Ser Pro Asn Leu Asp Phe Ser Asp Leu Thr Ser 
                325                 330                 335     


Ile Ser Glu Ile Val His Arg Cys Asn Lys Ile Pro Ile Pro Pro Arg 
            340                 345                 350         


Ala Pro Tyr Gly Gly Glu Leu Val Val Ser Ala Phe Ser Gly Ser His 
        355                 360                 365             


Gln Asp Ala Ile Lys Lys Gly Phe Ala Ile Gln Asn Lys Lys Gln Ala 
    370                 375                 380                 


Gln Gly Glu Thr Arg Trp Arg Ile Pro Tyr Leu Pro Leu Asp Pro Lys 
385                 390                 395                 400 


Asp Ile Gly Arg Asp Tyr Glu Ala Val Ile Arg Val Asn Ser Gln Ser 
                405                 410                 415     


Gly Lys Gly Gly Ala Ala Trp Val Ile Met Arg Ser Leu Gly Leu Asp 
            420                 425                 430         


Val Pro Arg Pro Met Gln Val Asp Phe Ser Asn Thr Leu Gln Lys Asn 
        435                 440                 445             


Ala Asp Ala Leu Gly Arg Glu Leu Lys Ser Glu Glu Ile Thr Lys Leu 
    450                 455                 460                 


Phe Lys Glu Thr Tyr Asn Tyr Asn Asn Asn Glu His Ile Tyr Val Thr 
465                 470                 475                 480 


Leu Leu Asn Tyr Glu Val Lys Lys Leu Asn Pro Glu Arg Arg Ala Leu 
                485                 490                 495     


Val Gly Gln Val Glu Ile Asn Asp Lys Val Val Asn Ile Glu Gly Tyr 
            500                 505                 510         


Gly Asn Gly Pro Ile Ser Ser Leu Val Asp Ala Leu Ser Asn Leu Leu 
        515                 520                 525             


Asn Val Lys Leu Ser Val Gln Asn Tyr Ser Glu His Ser Leu Gly Ser 
    530                 535                 540                 


Gly Ser Ala Thr Gln Ala Ala Ser Phe Ile Asn Leu Ser Tyr Ile Lys 
545                 550                 555                 560 


Asp Ile Asn Asn His Ala Thr Ser Asn Met Trp Gly Val Gly Val Ser 
                565                 570                 575     


Glu Asp Thr Gly Asp Ala Ser Ile Lys Ala Val Phe Ala Thr Val Asn 
            580                 585                 590         


Asn Ile Ile His Ser Gly Asp Val Leu Leu Ala Glu 
        595                 600                 


<210>  5
<211>  2340
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  5
atggtttaca ctccatccaa gggtccaaga actctttacg ataaggtttt tgatgcacat       60

gttgtccatc aagatgaaaa tggttccttt ttgttgtata tcgacagaca cttggttcat      120

gaagtcacct ctccacaagc tttcgaaggc ctagaaaatg ccggcagaaa ggtcagaaga      180

gttgattgta ctctagctac tgtagatcat aatattccaa ctgaatcaag aaagaatttc      240

aaatcactag acacatttat caagcaaact gattcgcgtt tacaagtcaa aactttagag      300

aataatgtta aacagttcgg cgttccatat ttcggtatga gtgatgccag acaaggtatc      360

gtccacacca tcggtcccga agaaggtttc actttaccag gtaccactgt tgtttgtggt      420

gactctcata cctctactca cggtgccttt ggttcgctgg cctttggtat tggtacttct      480

gaagttgaac acgtcttggc cactcaaaca attatccaag ctaaatcgaa aaacatgaga      540

attactgtta atggtaagct atcacctggt atcacatcta aagatttgat tttgtatatt      600

attggtctga taggtactgc aggtggtact ggttgcgtta ttgaattcgc aggtgaagcc      660

attgaagctc tttctatgga agcacgtatg tccatgtgta acatggccat cgaagctggt      720

gcaagagcag gtatgattaa accagacgaa actactttcc aatacaccaa aggcagacct      780

ttggctccaa aaggtgccga atgggaaaag gctgttgcct actggaaaac tttgaaaaca      840

gacgaaggtg ccaaatttga ccacgaaatc aacattgaag ctgtcgacgt gattccaact      900

attacatggg gtacttctcc tcaagatgcc ttaccaatta ctggttccgt accagatcca      960

aaaaatgtta cagacccaat aaagaaatct ggtatggaaa gagccttagc ctatatgggt     1020

ttggaaccta acacaccgct aaagagcatc aaagtagata aagtctttat tggatcttgt     1080

accaatggcc gtattgaaga tttaagaagt gctgcagctg tagttagggg tcaaaaattg     1140

gctagtaaca tcaaattagc tatggttgtt ccgggatctg gtttggtcaa aaaacaagcc     1200

gaagcagaag gtttggacaa gattttccaa gaagctggtt ttgaatggag agaagctggt     1260

tgttcaatat gtttaggtat gaaccctgat attttggatg cctatgaacg ttgtgcttct     1320

acttccaaca gaaatttcga aggtcgtcaa ggtgccttgt ctcgtacaca tctaatgtcc     1380

ccagccatgg cggctgctgc aggtatcgca ggtcacttcg tagatattag agaattcgaa     1440

tataaggatc aagaccaaag tagtccaaag gttgaggtca cttccgaaga tgaaaaagag     1500

cttgaaagtg ctgcttacga tcacgctgaa cctgtccaac ccgaagacgc tccccaagat     1560

attgccaatg atgaattaaa agatattcca gtgaagtcag atgatacacc tgctaaacct     1620

agctcttccg gcatgaagcc atttttgact ttggaaggta ttagcgcacc attagataag     1680

gccaatgttg atacagacgc tattatccca aagcaatttt taaagacaat taagagaacg     1740

ggtttgaaaa aagggttgtt ttatgaatgg cgtttccgta aagacgatca aggtaaggat     1800

caagaaaccg attttgtatt aaatgttgaa ccttggaggg aagctgaaat attggttgtt     1860

actggtgaca atttcggatg tggttcttcc agagaacacg caccatgggc tctaaaagac     1920

tttggtataa aatccatcat tgcaccttct tacggtgata ttttctacaa caactctttc     1980

aagaacggct tattacctat tagattggat caacaaataa tcattgacaa attgatccct     2040

attgctaata agggtggtaa gctctgcgtc gatttaccaa atcaaaaaat tttggattcc     2100

gatggcaatg tgctcgttga tcattttgaa atagaacctt tcagaaagca ctgcctagtt     2160

aacggtcttg atgatattgg tattacattg caaaaggaag aatacatttc cagatacgaa     2220

gctttgagaa gagagaaata ctcattcttg gaaggtggat caaaattatt aaaatttgac     2280

aacgttccaa aaagaaaagc tgttacaact actttcgata aagtccacca ggattggtag     2340


<210>  6
<211>  779
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Val Tyr Thr Pro Ser Lys Gly Pro Arg Thr Leu Tyr Asp Lys Val 
1               5                   10                  15      


Phe Asp Ala His Val Val His Gln Asp Glu Asn Gly Ser Phe Leu Leu 
            20                  25                  30          


Tyr Ile Asp Arg His Leu Val His Glu Val Thr Ser Pro Gln Ala Phe 
        35                  40                  45              


Glu Gly Leu Glu Asn Ala Gly Arg Lys Val Arg Arg Val Asp Cys Thr 
    50                  55                  60                  


Leu Ala Thr Val Asp His Asn Ile Pro Thr Glu Ser Arg Lys Asn Phe 
65                  70                  75                  80  


Lys Ser Leu Asp Thr Phe Ile Lys Gln Thr Asp Ser Arg Leu Gln Val 
                85                  90                  95      


Lys Thr Leu Glu Asn Asn Val Lys Gln Phe Gly Val Pro Tyr Phe Gly 
            100                 105                 110         


Met Ser Asp Ala Arg Gln Gly Ile Val His Thr Ile Gly Pro Glu Glu 
        115                 120                 125             


Gly Phe Thr Leu Pro Gly Thr Thr Val Val Cys Gly Asp Ser His Thr 
    130                 135                 140                 


Ser Thr His Gly Ala Phe Gly Ser Leu Ala Phe Gly Ile Gly Thr Ser 
145                 150                 155                 160 


Glu Val Glu His Val Leu Ala Thr Gln Thr Ile Ile Gln Ala Lys Ser 
                165                 170                 175     


Lys Asn Met Arg Ile Thr Val Asn Gly Lys Leu Ser Pro Gly Ile Thr 
            180                 185                 190         


Ser Lys Asp Leu Ile Leu Tyr Ile Ile Gly Leu Ile Gly Thr Ala Gly 
        195                 200                 205             


Gly Thr Gly Cys Val Ile Glu Phe Ala Gly Glu Ala Ile Glu Ala Leu 
    210                 215                 220                 


Ser Met Glu Ala Arg Met Ser Met Cys Asn Met Ala Ile Glu Ala Gly 
225                 230                 235                 240 


Ala Arg Ala Gly Met Ile Lys Pro Asp Glu Thr Thr Phe Gln Tyr Thr 
                245                 250                 255     


Lys Gly Arg Pro Leu Ala Pro Lys Gly Ala Glu Trp Glu Lys Ala Val 
            260                 265                 270         


Ala Tyr Trp Lys Thr Leu Lys Thr Asp Glu Gly Ala Lys Phe Asp His 
        275                 280                 285             


Glu Ile Asn Ile Glu Ala Val Asp Val Ile Pro Thr Ile Thr Trp Gly 
    290                 295                 300                 


Thr Ser Pro Gln Asp Ala Leu Pro Ile Thr Gly Ser Val Pro Asp Pro 
305                 310                 315                 320 


Lys Asn Val Thr Asp Pro Ile Lys Lys Ser Gly Met Glu Arg Ala Leu 
                325                 330                 335     


Ala Tyr Met Gly Leu Glu Pro Asn Thr Pro Leu Lys Ser Ile Lys Val 
            340                 345                 350         


Asp Lys Val Phe Ile Gly Ser Cys Thr Asn Gly Arg Ile Glu Asp Leu 
        355                 360                 365             


Arg Ser Ala Ala Ala Val Val Arg Gly Gln Lys Leu Ala Ser Asn Ile 
    370                 375                 380                 


Lys Leu Ala Met Val Val Pro Gly Ser Gly Leu Val Lys Lys Gln Ala 
385                 390                 395                 400 


Glu Ala Glu Gly Leu Asp Lys Ile Phe Gln Glu Ala Gly Phe Glu Trp 
                405                 410                 415     


Arg Glu Ala Gly Cys Ser Ile Cys Leu Gly Met Asn Pro Asp Ile Leu 
            420                 425                 430         


Asp Ala Tyr Glu Arg Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu Gly 
        435                 440                 445             


Arg Gln Gly Ala Leu Ser Arg Thr His Leu Met Ser Pro Ala Met Ala 
    450                 455                 460                 


Ala Ala Ala Gly Ile Ala Gly His Phe Val Asp Ile Arg Glu Phe Glu 
465                 470                 475                 480 


Tyr Lys Asp Gln Asp Gln Ser Ser Pro Lys Val Glu Val Thr Ser Glu 
                485                 490                 495     


Asp Glu Lys Glu Leu Glu Ser Ala Ala Tyr Asp His Ala Glu Pro Val 
            500                 505                 510         


Gln Pro Glu Asp Ala Pro Gln Asp Ile Ala Asn Asp Glu Leu Lys Asp 
        515                 520                 525             


Ile Pro Val Lys Ser Asp Asp Thr Pro Ala Lys Pro Ser Ser Ser Gly 
    530                 535                 540                 


Met Lys Pro Phe Leu Thr Leu Glu Gly Ile Ser Ala Pro Leu Asp Lys 
545                 550                 555                 560 


Ala Asn Val Asp Thr Asp Ala Ile Ile Pro Lys Gln Phe Leu Lys Thr 
                565                 570                 575     


Ile Lys Arg Thr Gly Leu Lys Lys Gly Leu Phe Tyr Glu Trp Arg Phe 
            580                 585                 590         


Arg Lys Asp Asp Gln Gly Lys Asp Gln Glu Thr Asp Phe Val Leu Asn 
        595                 600                 605             


Val Glu Pro Trp Arg Glu Ala Glu Ile Leu Val Val Thr Gly Asp Asn 
    610                 615                 620                 


Phe Gly Cys Gly Ser Ser Arg Glu His Ala Pro Trp Ala Leu Lys Asp 
625                 630                 635                 640 


Phe Gly Ile Lys Ser Ile Ile Ala Pro Ser Tyr Gly Asp Ile Phe Tyr 
                645                 650                 655     


Asn Asn Ser Phe Lys Asn Gly Leu Leu Pro Ile Arg Leu Asp Gln Gln 
            660                 665                 670         


Ile Ile Ile Asp Lys Leu Ile Pro Ile Ala Asn Lys Gly Gly Lys Leu 
        675                 680                 685             


Cys Val Asp Leu Pro Asn Gln Lys Ile Leu Asp Ser Asp Gly Asn Val 
    690                 695                 700                 


Leu Val Asp His Phe Glu Ile Glu Pro Phe Arg Lys His Cys Leu Val 
705                 710                 715                 720 


Asn Gly Leu Asp Asp Ile Gly Ile Thr Leu Gln Lys Glu Glu Tyr Ile 
                725                 730                 735     


Ser Arg Tyr Glu Ala Leu Arg Arg Glu Lys Tyr Ser Phe Leu Glu Gly 
            740                 745                 750         


Gly Ser Lys Leu Leu Lys Phe Asp Asn Val Pro Lys Arg Lys Ala Val 
        755                 760                 765             


Thr Thr Thr Phe Asp Lys Val His Gln Asp Trp 
    770                 775                 


<210>  7
<211>  1095
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  7
atgtctgccc ctaagaagat cgtcgttttg ccaggtgacc acgttggtca agaaatcaca       60

gccgaagcca ttaaggttct taaagctatt tctgatgttc gttccaatgt caagttcgat      120

ttcgaaaatc atttaattgg tggtgctgct atcgatgcta caggtgttcc acttccagat      180

gaggcgctgg aagcctccaa gaaggctgat gccgttttgt taggtgctgt gggtggtcct      240

aaatggggta ccggtagtgt tagacctgaa caaggtttac taaaaatccg taaagaactt      300

caattgtacg ccaacttaag accatgtaac tttgcatccg actctctttt agacttatct      360

ccaatcaagc cacaatttgc taaaggtact gacttcgttg ttgtcagaga attagtggga      420

ggtatttact ttggtaagag aaaggaagac gatggtgatg gtgtcgcttg ggatagtgaa      480

caatacaccg ttccagaagt gcaaagaatc acaagaatgg ccgctttcat ggccctacaa      540

catgagccac cattgcctat ttggtccttg gataaagcta atgttttggc ctcttcaaga      600

ttatggagaa aaactgtgga ggaaaccatc aagaacgaat tccctacatt gaaggttcaa      660

catcaattga ttgattctgc cgccatgatc ctagttaaga acccaaccca cctaaatggt      720

attataatca ccagcaacat gtttggtgat atcatctccg atgaagcctc cgttatccca      780

ggttccttgg gtttgttgcc atctgcgtcc ttggcctctt tgccagacaa gaacaccgca      840

tttggtttgt acgaaccatg ccacggttct gctccagatt tgccaaagaa taaggtcaac      900

cctatcgcca ctatcttgtc tgctgcaatg atgttgaaat tgtcattgaa cttgcctgaa      960

gaaggtaagg ccattgaaga tgcagttaaa aaggttttgg atgcaggtat cagaactggt     1020

gatttaggtg gttccaacag taccaccgaa gtcggtgatg ctgtcgccga agaagttaag     1080

aaaatccttg cttaa                                                      1095


<210>  8
<211>  364
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Ser Ala Pro Lys Lys Ile Val Val Leu Pro Gly Asp His Val Gly 
1               5                   10                  15      


Gln Glu Ile Thr Ala Glu Ala Ile Lys Val Leu Lys Ala Ile Ser Asp 
            20                  25                  30          


Val Arg Ser Asn Val Lys Phe Asp Phe Glu Asn His Leu Ile Gly Gly 
        35                  40                  45              


Ala Ala Ile Asp Ala Thr Gly Val Pro Leu Pro Asp Glu Ala Leu Glu 
    50                  55                  60                  


Ala Ser Lys Lys Ala Asp Ala Val Leu Leu Gly Ala Val Gly Gly Pro 
65                  70                  75                  80  


Lys Trp Gly Thr Gly Ser Val Arg Pro Glu Gln Gly Leu Leu Lys Ile 
                85                  90                  95      


Arg Lys Glu Leu Gln Leu Tyr Ala Asn Leu Arg Pro Cys Asn Phe Ala 
            100                 105                 110         


Ser Asp Ser Leu Leu Asp Leu Ser Pro Ile Lys Pro Gln Phe Ala Lys 
        115                 120                 125             


Gly Thr Asp Phe Val Val Val Arg Glu Leu Val Gly Gly Ile Tyr Phe 
    130                 135                 140                 


Gly Lys Arg Lys Glu Asp Asp Gly Asp Gly Val Ala Trp Asp Ser Glu 
145                 150                 155                 160 


Gln Tyr Thr Val Pro Glu Val Gln Arg Ile Thr Arg Met Ala Ala Phe 
                165                 170                 175     


Met Ala Leu Gln His Glu Pro Pro Leu Pro Ile Trp Ser Leu Asp Lys 
            180                 185                 190         


Ala Asn Val Leu Ala Ser Ser Arg Leu Trp Arg Lys Thr Val Glu Glu 
        195                 200                 205             


Thr Ile Lys Asn Glu Phe Pro Thr Leu Lys Val Gln His Gln Leu Ile 
    210                 215                 220                 


Asp Ser Ala Ala Met Ile Leu Val Lys Asn Pro Thr His Leu Asn Gly 
225                 230                 235                 240 


Ile Ile Ile Thr Ser Asn Met Phe Gly Asp Ile Ile Ser Asp Glu Ala 
                245                 250                 255     


Ser Val Ile Pro Gly Ser Leu Gly Leu Leu Pro Ser Ala Ser Leu Ala 
            260                 265                 270         


Ser Leu Pro Asp Lys Asn Thr Ala Phe Gly Leu Tyr Glu Pro Cys His 
        275                 280                 285             


Gly Ser Ala Pro Asp Leu Pro Lys Asn Lys Val Asn Pro Ile Ala Thr 
    290                 295                 300                 


Ile Leu Ser Ala Ala Met Met Leu Lys Leu Ser Leu Asn Leu Pro Glu 
305                 310                 315                 320 


Glu Gly Lys Ala Ile Glu Asp Ala Val Lys Lys Val Leu Asp Ala Gly 
                325                 330                 335     


Ile Arg Thr Gly Asp Leu Gly Gly Ser Asn Ser Thr Thr Glu Val Gly 
            340                 345                 350         


Asp Ala Val Ala Glu Glu Val Lys Lys Ile Leu Ala 
        355                 360                 


<210>  9
<211>  1182
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  9
atgttgcaga gacattcctt gaagttgggg aaattctcca tcagaacact cgctactggt       60

gccccattag atgcatccaa actaaaaatt actagaaacc caaatccatc caagccaaga      120

ccaaatgaag aattagtgtt cggccagaca ttcaccgatc atatgttgac cattccttgg      180

tcagccaaag aagggtgggg cactccacac atcaagcctt acggtaatct ttctcttgac      240

ccatctgctt gtgtattcca ttatgcattt gaattatttg aaggtttgaa agcctacaga      300

actcctcaaa atactatcac catgttccgt ccggataaga acatggcccg tatgaacaag      360

tctgccgcta gaatttgttt gccaactttc gaatctgaag aattgatcaa acttaccggg      420

aaattgatcg aacaagataa acacttggtt cctcaaggta atggttactc attatacatc      480

agaccaacaa tgattggtac atccaagggt ttaggtgttg gcactccctc cgaggctctt      540

ctttatgtta ttacttctcc agtcggtcct tattataaga ctggtttcaa agccgtacgt      600

cttgaagcaa cagactatgc tacaagagct tggccaggtg gtgttggcga caaaaaattg      660

ggtgctaact atgccccatg catcttacct caactacaag ctgccaaaag agggtaccaa      720

caaaatctat ggttgttcgg cccagaaaag aacatcactg aggttggtac tatgaacgtg      780

ttcttcgttt tcctcaacaa agtcactggc aagaaggaat tggttaccgc tccattagat      840

ggtaccattt tagaaggtgt taccagagac tctgttttaa cattggctcg tgacaaacta      900

gatcctcaag aatgggacat caacgagcgt tattacacta ttactgaagt cgccactaga      960

gcaaaacaag gtgaactatt agaagccttc ggttctggta ctgctgctgt cgtttcacct     1020

atcaaggaaa ttggctggaa caacgaagat attcatgttc cactattgcc tggtgaacaa     1080

tgtggtgcat tgaccaagca agttgctcaa tggattgctg atatccaata cggtagagtc     1140

aattatggta actggtcaaa aactgttgcc gacttgaact aa                        1182


<210>  10
<211>  393
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  10

Met Leu Gln Arg His Ser Leu Lys Leu Gly Lys Phe Ser Ile Arg Thr 
1               5                   10                  15      


Leu Ala Thr Gly Ala Pro Leu Asp Ala Ser Lys Leu Lys Ile Thr Arg 
            20                  25                  30          


Asn Pro Asn Pro Ser Lys Pro Arg Pro Asn Glu Glu Leu Val Phe Gly 
        35                  40                  45              


Gln Thr Phe Thr Asp His Met Leu Thr Ile Pro Trp Ser Ala Lys Glu 
    50                  55                  60                  


Gly Trp Gly Thr Pro His Ile Lys Pro Tyr Gly Asn Leu Ser Leu Asp 
65                  70                  75                  80  


Pro Ser Ala Cys Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Leu 
                85                  90                  95      


Lys Ala Tyr Arg Thr Pro Gln Asn Thr Ile Thr Met Phe Arg Pro Asp 
            100                 105                 110         


Lys Asn Met Ala Arg Met Asn Lys Ser Ala Ala Arg Ile Cys Leu Pro 
        115                 120                 125             


Thr Phe Glu Ser Glu Glu Leu Ile Lys Leu Thr Gly Lys Leu Ile Glu 
    130                 135                 140                 


Gln Asp Lys His Leu Val Pro Gln Gly Asn Gly Tyr Ser Leu Tyr Ile 
145                 150                 155                 160 


Arg Pro Thr Met Ile Gly Thr Ser Lys Gly Leu Gly Val Gly Thr Pro 
                165                 170                 175     


Ser Glu Ala Leu Leu Tyr Val Ile Thr Ser Pro Val Gly Pro Tyr Tyr 
            180                 185                 190         


Lys Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr 
        195                 200                 205             


Arg Ala Trp Pro Gly Gly Val Gly Asp Lys Lys Leu Gly Ala Asn Tyr 
    210                 215                 220                 


Ala Pro Cys Ile Leu Pro Gln Leu Gln Ala Ala Lys Arg Gly Tyr Gln 
225                 230                 235                 240 


Gln Asn Leu Trp Leu Phe Gly Pro Glu Lys Asn Ile Thr Glu Val Gly 
                245                 250                 255     


Thr Met Asn Val Phe Phe Val Phe Leu Asn Lys Val Thr Gly Lys Lys 
            260                 265                 270         


Glu Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr 
        275                 280                 285             


Arg Asp Ser Val Leu Thr Leu Ala Arg Asp Lys Leu Asp Pro Gln Glu 
    290                 295                 300                 


Trp Asp Ile Asn Glu Arg Tyr Tyr Thr Ile Thr Glu Val Ala Thr Arg 
305                 310                 315                 320 


Ala Lys Gln Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala 
                325                 330                 335     


Val Val Ser Pro Ile Lys Glu Ile Gly Trp Asn Asn Glu Asp Ile His 
            340                 345                 350         


Val Pro Leu Leu Pro Gly Glu Gln Cys Gly Ala Leu Thr Lys Gln Val 
        355                 360                 365             


Ala Gln Trp Ile Ala Asp Ile Gln Tyr Gly Arg Val Asn Tyr Gly Asn 
    370                 375                 380                 


Trp Ser Lys Thr Val Ala Asp Leu Asn 
385                 390             


<210>  11
<211>  1131
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  11
atgaccttgg cacccctaga cgcctccaaa gttaagataa ctaccacaca acatgcatct       60

aagccaaaac cgaacagtga gttagtgttt ggcaagagct tcacggacca catgttaact      120

gcggaatgga cagctgaaaa agggtggggt accccagaga ttaaacctta tcaaaatctg      180

tctttagacc cttccgcggt ggttttccat tatgcttttg agctattcga agggatgaag      240

gcttacagaa cggtggacaa caaaattaca atgtttcgtc cagatatgaa tatgaagcgc      300

atgaataagt ctgctcagag aatctgtttg ccaacgttcg acccagaaga gttgattacc      360

ctaattggga aactgatcca gcaagataag tgcttagttc ctgaaggaaa aggttactct      420

ttatatatca ggcctacatt aatcggcact acggccggtt taggggtttc cacgcctgat      480

agagccttgc tatatgtcat ttgctgccct gtgggtcctt attacaaaac tggatttaag      540

gcggtcagac tggaagccac tgattatgcc acaagagctt ggccaggagg ctgtggtgac      600

aagaaactag gtgcaaacta cgccccctgc gtcctgccac aattgcaagc tgcttcaagg      660

ggttaccaac aaaatttatg gctatttggt ccaaataaca acattactga agtcggcacc      720

atgaatgctt ttttcgtgtt taaagatagt aaaacgggca agaaggaact agttactgct      780

ccactagacg gtaccatttt ggaaggtgtt actagggatt ccattttaaa tcttgctaaa      840

gaaagactcg aaccaagtga atggaccatt agtgaacgct acttcactat aggcgaagtt      900

actgagagat ccaagaacgg tgaactactt gaagcctttg gttctggtac tgctgcgatt      960

gtttctccca ttaaggaaat cggctggaaa ggcgaacaaa ttaatattcc gttgttgccc     1020

ggcgaacaaa ccggtccatt ggccaaagaa gttgcacaat ggattaatgg aatccaatat     1080

ggcgagactg agcatggcaa ttggtcaagg gttgttactg atttgaactg a              1131


<210>  12
<211>  376
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  12

Met Thr Leu Ala Pro Leu Asp Ala Ser Lys Val Lys Ile Thr Thr Thr 
1               5                   10                  15      


Gln His Ala Ser Lys Pro Lys Pro Asn Ser Glu Leu Val Phe Gly Lys 
            20                  25                  30          


Ser Phe Thr Asp His Met Leu Thr Ala Glu Trp Thr Ala Glu Lys Gly 
        35                  40                  45              


Trp Gly Thr Pro Glu Ile Lys Pro Tyr Gln Asn Leu Ser Leu Asp Pro 
    50                  55                  60                  


Ser Ala Val Val Phe His Tyr Ala Phe Glu Leu Phe Glu Gly Met Lys 
65                  70                  75                  80  


Ala Tyr Arg Thr Val Asp Asn Lys Ile Thr Met Phe Arg Pro Asp Met 
                85                  90                  95      


Asn Met Lys Arg Met Asn Lys Ser Ala Gln Arg Ile Cys Leu Pro Thr 
            100                 105                 110         


Phe Asp Pro Glu Glu Leu Ile Thr Leu Ile Gly Lys Leu Ile Gln Gln 
        115                 120                 125             


Asp Lys Cys Leu Val Pro Glu Gly Lys Gly Tyr Ser Leu Tyr Ile Arg 
    130                 135                 140                 


Pro Thr Leu Ile Gly Thr Thr Ala Gly Leu Gly Val Ser Thr Pro Asp 
145                 150                 155                 160 


Arg Ala Leu Leu Tyr Val Ile Cys Cys Pro Val Gly Pro Tyr Tyr Lys 
                165                 170                 175     


Thr Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr Arg 
            180                 185                 190         


Ala Trp Pro Gly Gly Cys Gly Asp Lys Lys Leu Gly Ala Asn Tyr Ala 
        195                 200                 205             


Pro Cys Val Leu Pro Gln Leu Gln Ala Ala Ser Arg Gly Tyr Gln Gln 
    210                 215                 220                 


Asn Leu Trp Leu Phe Gly Pro Asn Asn Asn Ile Thr Glu Val Gly Thr 
225                 230                 235                 240 


Met Asn Ala Phe Phe Val Phe Lys Asp Ser Lys Thr Gly Lys Lys Glu 
                245                 250                 255     


Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg 
            260                 265                 270         


Asp Ser Ile Leu Asn Leu Ala Lys Glu Arg Leu Glu Pro Ser Glu Trp 
        275                 280                 285             


Thr Ile Ser Glu Arg Tyr Phe Thr Ile Gly Glu Val Thr Glu Arg Ser 
    290                 295                 300                 


Lys Asn Gly Glu Leu Leu Glu Ala Phe Gly Ser Gly Thr Ala Ala Ile 
305                 310                 315                 320 


Val Ser Pro Ile Lys Glu Ile Gly Trp Lys Gly Glu Gln Ile Asn Ile 
                325                 330                 335     


Pro Leu Leu Pro Gly Glu Gln Thr Gly Pro Leu Ala Lys Glu Val Ala 
            340                 345                 350         


Gln Trp Ile Asn Gly Ile Gln Tyr Gly Glu Thr Glu His Gly Asn Trp 
        355                 360                 365             


Ser Arg Val Val Thr Asp Leu Asn 
    370                 375     


<210>  13
<211>  1908
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  13
atggcacctg ttacaattga aaagttcgta aatcaagaag aacgacacct tgtttccaac       60

cgatcagcaa caattccgtt tggtgaatac atatttaaaa gattgttgtc catcgatacg      120

aaatcagttt tcggtgttcc tggtgacttc aacttatctc tattagaata tctctattca      180

cctagtgttg aatcagctgg cctaagatgg gtcggcacgt gtaatgaact gaacgccgct      240

tatgcggccg acggatattc ccgttactct aataagattg gctgtttaat aaccacgtat      300

ggcgttggtg aattaagcgc cttgaacggt atagccggtt cgttcgctga aaatgtcaaa      360

gttttgcaca ttgttggtgt ggccaagtcc atagattcgc gttcaagtaa ctttagtgat      420

cggaacctac atcatttggt cccacagcta catgattcaa attttaaagg gccaaatcat      480

aaagtatatc atgatatggt aaaagataga gtcgcttgct cggtagccta cttggaggat      540

attgaaactg catgtgacca agtcgataat gttatccgcg atatttacaa gtattctaaa      600

cctggttata tttttgttcc tgcagatttt gcggatatgt ctgttacatg tgataatttg      660

gttaatgttc cacgtatatc tcaacaagat tgtatagtat acccttctga aaaccaattg      720

tctgacataa tcaacaagat tactagttgg atatattcca gtaaaacacc tgcgatcctt      780

ggagacgtac tgactgatag gtatggtgtg agtaactttt tgaacaagct tatctgcaaa      840

actgggattt ggaatttttc cactgttatg ggaaaatctg taattgatga gtcaaaccca      900

acttatatgg gtcaatataa tggtaaagaa ggtttaaaac aagtctatga acattttgaa      960

ctgtgcgact tggtcttgca ttttggagtc gacatcaatg aaattaataa tgggcattat     1020

acttttactt ataaaccaaa tgctaaaatc attcaatttc atccgaatta tattcgcctt     1080

gtggacacta ggcagggcaa tgagcaaatg ttcaaaggaa tcaattttgc ccctatttta     1140

aaagaactat acaagcgcat tgacgtttct aaactttctt tgcaatatga ttcaaatgta     1200

actcaatata cgaacgaaac aatgcggtta gaagatccta ccaatggaca atcaagcatt     1260

attacacaag ttcacttaca aaagacgatg cctaaatttt tgaaccctgg tgatgttgtc     1320

gtttgtgaaa caggctcttt tcaattctct gttcgtgatt tcgcgtttcc ttcgcaatta     1380

aaatatatat cgcaaggatt tttcctttcc attggcatgg cccttcctgc cgccctaggt     1440

gttggaattg ccatgcaaga ccactcaaac gctcacatca atggtggcaa cgtaaaagag     1500

gactataagc caagattaat tttgtttgaa ggtgacggtg cagcacagat gacaatccaa     1560

gaactgagca ccattctgaa gtgcaatatt ccactagaag ttatcatttg gaacaataac     1620

ggctacacta ttgaaagagc catcatgggc cctaccaggt cgtataacga cgttatgtct     1680

tggaaatgga ccaaactatt tgaagcattc ggagacttcg acggaaagta tactaatagc     1740

actctcattc aatgtccctc taaattagca ctgaaattgg aggagcttaa gaattcaaac     1800

aaaagaagcg ggatagaact tttagaagtc aaattaggcg aattggattt ccccgaacag     1860

ctaaagtgca tggttgaagc agcggcactt aaaagaaata aaaaatag                  1908


<210>  14
<211>  635
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Ala Pro Val Thr Ile Glu Lys Phe Val Asn Gln Glu Glu Arg His 
1               5                   10                  15      


Leu Val Ser Asn Arg Ser Ala Thr Ile Pro Phe Gly Glu Tyr Ile Phe 
            20                  25                  30          


Lys Arg Leu Leu Ser Ile Asp Thr Lys Ser Val Phe Gly Val Pro Gly 
        35                  40                  45              


Asp Phe Asn Leu Ser Leu Leu Glu Tyr Leu Tyr Ser Pro Ser Val Glu 
    50                  55                  60                  


Ser Ala Gly Leu Arg Trp Val Gly Thr Cys Asn Glu Leu Asn Ala Ala 
65                  70                  75                  80  


Tyr Ala Ala Asp Gly Tyr Ser Arg Tyr Ser Asn Lys Ile Gly Cys Leu 
                85                  90                  95      


Ile Thr Thr Tyr Gly Val Gly Glu Leu Ser Ala Leu Asn Gly Ile Ala 
            100                 105                 110         


Gly Ser Phe Ala Glu Asn Val Lys Val Leu His Ile Val Gly Val Ala 
        115                 120                 125             


Lys Ser Ile Asp Ser Arg Ser Ser Asn Phe Ser Asp Arg Asn Leu His 
    130                 135                 140                 


His Leu Val Pro Gln Leu His Asp Ser Asn Phe Lys Gly Pro Asn His 
145                 150                 155                 160 


Lys Val Tyr His Asp Met Val Lys Asp Arg Val Ala Cys Ser Val Ala 
                165                 170                 175     


Tyr Leu Glu Asp Ile Glu Thr Ala Cys Asp Gln Val Asp Asn Val Ile 
            180                 185                 190         


Arg Asp Ile Tyr Lys Tyr Ser Lys Pro Gly Tyr Ile Phe Val Pro Ala 
        195                 200                 205             


Asp Phe Ala Asp Met Ser Val Thr Cys Asp Asn Leu Val Asn Val Pro 
    210                 215                 220                 


Arg Ile Ser Gln Gln Asp Cys Ile Val Tyr Pro Ser Glu Asn Gln Leu 
225                 230                 235                 240 


Ser Asp Ile Ile Asn Lys Ile Thr Ser Trp Ile Tyr Ser Ser Lys Thr 
                245                 250                 255     


Pro Ala Ile Leu Gly Asp Val Leu Thr Asp Arg Tyr Gly Val Ser Asn 
            260                 265                 270         


Phe Leu Asn Lys Leu Ile Cys Lys Thr Gly Ile Trp Asn Phe Ser Thr 
        275                 280                 285             


Val Met Gly Lys Ser Val Ile Asp Glu Ser Asn Pro Thr Tyr Met Gly 
    290                 295                 300                 


Gln Tyr Asn Gly Lys Glu Gly Leu Lys Gln Val Tyr Glu His Phe Glu 
305                 310                 315                 320 


Leu Cys Asp Leu Val Leu His Phe Gly Val Asp Ile Asn Glu Ile Asn 
                325                 330                 335     


Asn Gly His Tyr Thr Phe Thr Tyr Lys Pro Asn Ala Lys Ile Ile Gln 
            340                 345                 350         


Phe His Pro Asn Tyr Ile Arg Leu Val Asp Thr Arg Gln Gly Asn Glu 
        355                 360                 365             


Gln Met Phe Lys Gly Ile Asn Phe Ala Pro Ile Leu Lys Glu Leu Tyr 
    370                 375                 380                 


Lys Arg Ile Asp Val Ser Lys Leu Ser Leu Gln Tyr Asp Ser Asn Val 
385                 390                 395                 400 


Thr Gln Tyr Thr Asn Glu Thr Met Arg Leu Glu Asp Pro Thr Asn Gly 
                405                 410                 415     


Gln Ser Ser Ile Ile Thr Gln Val His Leu Gln Lys Thr Met Pro Lys 
            420                 425                 430         


Phe Leu Asn Pro Gly Asp Val Val Val Cys Glu Thr Gly Ser Phe Gln 
        435                 440                 445             


Phe Ser Val Arg Asp Phe Ala Phe Pro Ser Gln Leu Lys Tyr Ile Ser 
    450                 455                 460                 


Gln Gly Phe Phe Leu Ser Ile Gly Met Ala Leu Pro Ala Ala Leu Gly 
465                 470                 475                 480 


Val Gly Ile Ala Met Gln Asp His Ser Asn Ala His Ile Asn Gly Gly 
                485                 490                 495     


Asn Val Lys Glu Asp Tyr Lys Pro Arg Leu Ile Leu Phe Glu Gly Asp 
            500                 505                 510         


Gly Ala Ala Gln Met Thr Ile Gln Glu Leu Ser Thr Ile Leu Lys Cys 
        515                 520                 525             


Asn Ile Pro Leu Glu Val Ile Ile Trp Asn Asn Asn Gly Tyr Thr Ile 
    530                 535                 540                 


Glu Arg Ala Ile Met Gly Pro Thr Arg Ser Tyr Asn Asp Val Met Ser 
545                 550                 555                 560 


Trp Lys Trp Thr Lys Leu Phe Glu Ala Phe Gly Asp Phe Asp Gly Lys 
                565                 570                 575     


Tyr Thr Asn Ser Thr Leu Ile Gln Cys Pro Ser Lys Leu Ala Leu Lys 
            580                 585                 590         


Leu Glu Glu Leu Lys Asn Ser Asn Lys Arg Ser Gly Ile Glu Leu Leu 
        595                 600                 605             


Glu Val Lys Leu Gly Glu Leu Asp Phe Pro Glu Gln Leu Lys Cys Met 
    610                 615                 620                 


Val Glu Ala Ala Ala Leu Lys Arg Asn Lys Lys 
625                 630                 635 


<210>  15
<211>  1830
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  15
atgaattcta gctatacaca gagatatgca ctgccgaagt gtatagcaat atcagattat       60

cttttccatc ggctcaacca gctgaacata cataccatat ttggactctc cggagaattt      120

agcatgccgt tgctggataa actatacaac attccgaact tacgatgggc cggtaattct      180

aatgagttaa atgctgccta cgcagcagat ggatactcac gactaaaagg cttgggatgt      240

ctcataacaa cctttggtgt aggcgaatta tcggcaatca atggcgtggc cggatcttac      300

gctgaacatg taggaatact tcacatagtg ggtatgccgc caacaagtgc acaaacgaaa      360

caactactac tgcatcatac tctgggcaat ggtgatttca cggtatttca tagaatagcc      420

agtgatgtag catgctatac aacattgatt attgactctg aattatgtgc cgacgaagtc      480

gataagtgca tcaaaaaggc ttggatagaa cagaggccag tatacatggg catgcctgtc      540

aaccaggtaa atctcccgat tgaatcagca aggcttaata cacctctgga tttacaattg      600

cataaaaacg acccagacgt agagaaagaa gttatttctc gaatattgag ttttatatac      660

aaaagccaga atccggcaat catcgtagat gcatgtacta gtcgacagaa tttaatcgag      720

gagactaaag agctttgtaa taggcttaaa tttccagttt ttgttacacc tatgggtaag      780

ggtacagtaa acgaaacaga cccgcaattt gggggcgtat tcacgggctc gatatcagcc      840

ccagaagtaa gagaagtagt tgattttgcc gattttatca tcgtcattgg ttgcatgctc      900

tccgaattca gcacgtcaac tttccacttc caatataaaa ctaagaattg tgcgctacta      960

tattctacat ctgtgaaatt gaaaaatgcc acatatcctg acttgagcat taaattacta     1020

ctacagaaaa tattagcaaa tcttgatgaa tctaaactgt cttaccaacc aagcgaacaa     1080

cccagtatga tggttccaag accttaccca gcaggaaatg tcctcttgag acaagaatgg     1140

gtctggaatg aaatatccca ttggttccaa ccaggtgaca taatcataac agaaactggt     1200

gcttctgcat ttggagttaa ccagaccaga tttccggtaa atacactagg tatttcgcaa     1260

gctctttggg gatctgtcgg atatacaatg ggggcgtgtc ttggggcaga atttgctgtt     1320

caagagataa acaaggataa attccccgca actaaacata gagttattct gtttatgggt     1380

gacggtgctt tccaattgac agttcaagaa ttatccacaa ttgttaagtg gggattgaca     1440

ccttatattt ttgtgatgaa taaccaaggt tactctgtgg acaggttttt gcatcacagg     1500

tcagatgcta gttattacga tatccaacct tggaactact tgggattatt gcgagtattt     1560

ggttgcacga actacgaaac gaaaaaaatt attactgttg gagaattcag atccatgatc     1620

agtgacccaa actttgcgac caatgacaaa attcggatga tagagattat gctaccacca     1680

agggatgttc cacaggctct gcttgacagg tgggtggtag aaaaagaaca gagcaaacaa     1740

gtgcaagagg agaacgaaaa ttctagcgca gtaaatacgc caactccaga attccaacca     1800

cttctaaaaa aaaatcaagt tggatactga                                      1830


<210>  16
<211>  609
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  16

Met Asn Ser Ser Tyr Thr Gln Arg Tyr Ala Leu Pro Lys Cys Ile Ala 
1               5                   10                  15      


Ile Ser Asp Tyr Leu Phe His Arg Leu Asn Gln Leu Asn Ile His Thr 
            20                  25                  30          


Ile Phe Gly Leu Ser Gly Glu Phe Ser Met Pro Leu Leu Asp Lys Leu 
        35                  40                  45              


Tyr Asn Ile Pro Asn Leu Arg Trp Ala Gly Asn Ser Asn Glu Leu Asn 
    50                  55                  60                  


Ala Ala Tyr Ala Ala Asp Gly Tyr Ser Arg Leu Lys Gly Leu Gly Cys 
65                  70                  75                  80  


Leu Ile Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Ile Asn Gly Val 
                85                  90                  95      


Ala Gly Ser Tyr Ala Glu His Val Gly Ile Leu His Ile Val Gly Met 
            100                 105                 110         


Pro Pro Thr Ser Ala Gln Thr Lys Gln Leu Leu Leu His His Thr Leu 
        115                 120                 125             


Gly Asn Gly Asp Phe Thr Val Phe His Arg Ile Ala Ser Asp Val Ala 
    130                 135                 140                 


Cys Tyr Thr Thr Leu Ile Ile Asp Ser Glu Leu Cys Ala Asp Glu Val 
145                 150                 155                 160 


Asp Lys Cys Ile Lys Lys Ala Trp Ile Glu Gln Arg Pro Val Tyr Met 
                165                 170                 175     


Gly Met Pro Val Asn Gln Val Asn Leu Pro Ile Glu Ser Ala Arg Leu 
            180                 185                 190         


Asn Thr Pro Leu Asp Leu Gln Leu His Lys Asn Asp Pro Asp Val Glu 
        195                 200                 205             


Lys Glu Val Ile Ser Arg Ile Leu Ser Phe Ile Tyr Lys Ser Gln Asn 
    210                 215                 220                 


Pro Ala Ile Ile Val Asp Ala Cys Thr Ser Arg Gln Asn Leu Ile Glu 
225                 230                 235                 240 


Glu Thr Lys Glu Leu Cys Asn Arg Leu Lys Phe Pro Val Phe Val Thr 
                245                 250                 255     


Pro Met Gly Lys Gly Thr Val Asn Glu Thr Asp Pro Gln Phe Gly Gly 
            260                 265                 270         


Val Phe Thr Gly Ser Ile Ser Ala Pro Glu Val Arg Glu Val Val Asp 
        275                 280                 285             


Phe Ala Asp Phe Ile Ile Val Ile Gly Cys Met Leu Ser Glu Phe Ser 
    290                 295                 300                 


Thr Ser Thr Phe His Phe Gln Tyr Lys Thr Lys Asn Cys Ala Leu Leu 
305                 310                 315                 320 


Tyr Ser Thr Ser Val Lys Leu Lys Asn Ala Thr Tyr Pro Asp Leu Ser 
                325                 330                 335     


Ile Lys Leu Leu Leu Gln Lys Ile Leu Ala Asn Leu Asp Glu Ser Lys 
            340                 345                 350         


Leu Ser Tyr Gln Pro Ser Glu Gln Pro Ser Met Met Val Pro Arg Pro 
        355                 360                 365             


Tyr Pro Ala Gly Asn Val Leu Leu Arg Gln Glu Trp Val Trp Asn Glu 
    370                 375                 380                 


Ile Ser His Trp Phe Gln Pro Gly Asp Ile Ile Ile Thr Glu Thr Gly 
385                 390                 395                 400 


Ala Ser Ala Phe Gly Val Asn Gln Thr Arg Phe Pro Val Asn Thr Leu 
                405                 410                 415     


Gly Ile Ser Gln Ala Leu Trp Gly Ser Val Gly Tyr Thr Met Gly Ala 
            420                 425                 430         


Cys Leu Gly Ala Glu Phe Ala Val Gln Glu Ile Asn Lys Asp Lys Phe 
        435                 440                 445             


Pro Ala Thr Lys His Arg Val Ile Leu Phe Met Gly Asp Gly Ala Phe 
    450                 455                 460                 


Gln Leu Thr Val Gln Glu Leu Ser Thr Ile Val Lys Trp Gly Leu Thr 
465                 470                 475                 480 


Pro Tyr Ile Phe Val Met Asn Asn Gln Gly Tyr Ser Val Asp Arg Phe 
                485                 490                 495     


Leu His His Arg Ser Asp Ala Ser Tyr Tyr Asp Ile Gln Pro Trp Asn 
            500                 505                 510         


Tyr Leu Gly Leu Leu Arg Val Phe Gly Cys Thr Asn Tyr Glu Thr Lys 
        515                 520                 525             


Lys Ile Ile Thr Val Gly Glu Phe Arg Ser Met Ile Ser Asp Pro Asn 
    530                 535                 540                 


Phe Ala Thr Asn Asp Lys Ile Arg Met Ile Glu Ile Met Leu Pro Pro 
545                 550                 555                 560 


Arg Asp Val Pro Gln Ala Leu Leu Asp Arg Trp Val Val Glu Lys Glu 
                565                 570                 575     


Gln Ser Lys Gln Val Gln Glu Glu Asn Glu Asn Ser Ser Ala Val Asn 
            580                 585                 590         


Thr Pro Thr Pro Glu Phe Gln Pro Leu Leu Lys Lys Asn Gln Val Gly 
        595                 600                 605             


Tyr 
    


<210>  17
<211>  1083
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  17
atgtcttatc ctgagaaatt tgaaggtatc gctattcaat cacacgaaga ttggaaaaac       60

ccaaagaaga caaagtatga cccaaaacca ttttacgatc atgacattga cattaagatc      120

gaagcatgtg gtgtctgcgg tagtgatatt cattgtgcag ctggtcattg gggcaatatg      180

aagatgccgc tagtcgttgg tcatgaaatc gttggtaaag ttgtcaagct agggcccaag      240

tcaaacagtg ggttgaaagt cggtcaacgt gttggtgtag gtgctcaagt cttttcatgc      300

ttggaatgtg accgttgtaa gaatgataat gaaccatact gcaccaagtt tgttaccaca      360

tacagtcagc cttatgaaga cggctatgtg tcgcagggtg gctatgcaaa ctacgtcaga      420

gttcatgaac attttgtggt gcctatccca gagaatattc catcacattt ggctgctcca      480

ctattatgtg gtggtttgac tgtgtactct ccattggttc gtaacggttg cggtccaggt      540

aaaaaagttg gtatagttgg tcttggtggt atcggcagta tgggtacatt gatttccaaa      600

gccatggggg cagagacgta tgttatttct cgttcttcga gaaaaagaga agatgcaatg      660

aagatgggcg ccgatcacta cattgctaca ttagaagaag gtgattgggg tgaaaagtac      720

tttgacacct tcgacctgat tgtagtctgt gcttcctccc ttaccgacat tgacttcaac      780

attatgccaa aggctatgaa ggttggtggt agaattgtct caatctctat accagaacaa      840

cacgaaatgt tatcgctaaa gccatatggc ttaaaggctg tctccatttc ttacagtgct      900

ttaggttcca tcaaagaatt gaaccaactc ttgaaattag tctctgaaaa agatatcaaa      960

atttgggtgg aaacattacc tgttggtgaa gccggcgtcc atgaagcctt cgaaaggatg     1020

gaaaagggtg acgttagata tagatttacc ttagtcggct acgacaaaga attttcagac     1080

tag                                                                   1083


<210>  18
<211>  360
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  18

Met Ser Tyr Pro Glu Lys Phe Glu Gly Ile Ala Ile Gln Ser His Glu 
1               5                   10                  15      


Asp Trp Lys Asn Pro Lys Lys Thr Lys Tyr Asp Pro Lys Pro Phe Tyr 
            20                  25                  30          


Asp His Asp Ile Asp Ile Lys Ile Glu Ala Cys Gly Val Cys Gly Ser 
        35                  40                  45              


Asp Ile His Cys Ala Ala Gly His Trp Gly Asn Met Lys Met Pro Leu 
    50                  55                  60                  


Val Val Gly His Glu Ile Val Gly Lys Val Val Lys Leu Gly Pro Lys 
65                  70                  75                  80  


Ser Asn Ser Gly Leu Lys Val Gly Gln Arg Val Gly Val Gly Ala Gln 
                85                  90                  95      


Val Phe Ser Cys Leu Glu Cys Asp Arg Cys Lys Asn Asp Asn Glu Pro 
            100                 105                 110         


Tyr Cys Thr Lys Phe Val Thr Thr Tyr Ser Gln Pro Tyr Glu Asp Gly 
        115                 120                 125             


Tyr Val Ser Gln Gly Gly Tyr Ala Asn Tyr Val Arg Val His Glu His 
    130                 135                 140                 


Phe Val Val Pro Ile Pro Glu Asn Ile Pro Ser His Leu Ala Ala Pro 
145                 150                 155                 160 


Leu Leu Cys Gly Gly Leu Thr Val Tyr Ser Pro Leu Val Arg Asn Gly 
                165                 170                 175     


Cys Gly Pro Gly Lys Lys Val Gly Ile Val Gly Leu Gly Gly Ile Gly 
            180                 185                 190         


Ser Met Gly Thr Leu Ile Ser Lys Ala Met Gly Ala Glu Thr Tyr Val 
        195                 200                 205             


Ile Ser Arg Ser Ser Arg Lys Arg Glu Asp Ala Met Lys Met Gly Ala 
    210                 215                 220                 


Asp His Tyr Ile Ala Thr Leu Glu Glu Gly Asp Trp Gly Glu Lys Tyr 
225                 230                 235                 240 


Phe Asp Thr Phe Asp Leu Ile Val Val Cys Ala Ser Ser Leu Thr Asp 
                245                 250                 255     


Ile Asp Phe Asn Ile Met Pro Lys Ala Met Lys Val Gly Gly Arg Ile 
            260                 265                 270         


Val Ser Ile Ser Ile Pro Glu Gln His Glu Met Leu Ser Leu Lys Pro 
        275                 280                 285             


Tyr Gly Leu Lys Ala Val Ser Ile Ser Tyr Ser Ala Leu Gly Ser Ile 
    290                 295                 300                 


Lys Glu Leu Asn Gln Leu Leu Lys Leu Val Ser Glu Lys Asp Ile Lys 
305                 310                 315                 320 


Ile Trp Val Glu Thr Leu Pro Val Gly Glu Ala Gly Val His Glu Ala 
                325                 330                 335     


Phe Glu Arg Met Glu Lys Gly Asp Val Arg Tyr Arg Phe Thr Leu Val 
            340                 345                 350         


Gly Tyr Asp Lys Glu Phe Ser Asp 
        355                 360 


<210>  19
<211>  1086
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  19
atgctttacc cagaaaaatt tcagggcatc ggtatttcca acgcaaagga ttggaagcat       60

cctaaattag tgagttttga cccaaaaccc tttggcgatc atgacgttga tgttgaaatt      120

gaagcctgtg gtatctgcgg atctgatttt catatagccg ttggtaattg gggtccagtc      180

ccagaaaatc aaatccttgg acatgaaata attggccgcg tggtgaaggt tggatccaag      240

tgccacactg gggtaaaaat cggtgaccgt gttggtgttg gtgcccaagc cttggcgtgt      300

tttgagtgtg aacgttgcaa aagtgacaac gagcaatact gtaccaatga ccacgttttg      360

actatgtgga ctccttacaa ggacggctac atttcacaag gaggctttgc ctcccacgtg      420

aggcttcatg aacactttgc tattcaaata ccagaaaata ttccaagtcc gctagccgct      480

ccattattgt gtggtggtat tacagttttc tctccactac taagaaatgg ctgtggtcca      540

ggtaagaggg taggtattgt tggcatcggt ggtattgggc atatggggat tctgttggct      600

aaagctatgg gagccgaggt ttatgcgttt tcgcgaggcc actccaagcg ggaggattct      660

atgaaactcg gtgctgatca ctatattgct atgttggagg ataaaggctg gacagaacaa      720

tactctaacg ctttggacct tcttgtcgtt tgctcatcat ctttgtcgaa agttaatttt      780

gacagtatcg ttaagattat gaagattgga ggctccatcg tttcaattgc tgctcctgaa      840

gttaatgaaa agcttgtttt aaaaccgttg ggcctaatgg gagtatcaat ctcaagcagt      900

gctatcggat ctaggaagga aatcgaacaa ctattgaaat tagtttccga aaagaatgtc      960

aaaatatggg tggaaaaact tccgatcagc gaagaaggcg tcagccatgc ctttacaagg     1020

atggaaagcg gagacgtcaa atacagattt actttggtcg attatgataa gaaattccat     1080

aaatag                                                                1086


<210>  20
<211>  361
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  20

Met Leu Tyr Pro Glu Lys Phe Gln Gly Ile Gly Ile Ser Asn Ala Lys 
1               5                   10                  15      


Asp Trp Lys His Pro Lys Leu Val Ser Phe Asp Pro Lys Pro Phe Gly 
            20                  25                  30          


Asp His Asp Val Asp Val Glu Ile Glu Ala Cys Gly Ile Cys Gly Ser 
        35                  40                  45              


Asp Phe His Ile Ala Val Gly Asn Trp Gly Pro Val Pro Glu Asn Gln 
    50                  55                  60                  


Ile Leu Gly His Glu Ile Ile Gly Arg Val Val Lys Val Gly Ser Lys 
65                  70                  75                  80  


Cys His Thr Gly Val Lys Ile Gly Asp Arg Val Gly Val Gly Ala Gln 
                85                  90                  95      


Ala Leu Ala Cys Phe Glu Cys Glu Arg Cys Lys Ser Asp Asn Glu Gln 
            100                 105                 110         


Tyr Cys Thr Asn Asp His Val Leu Thr Met Trp Thr Pro Tyr Lys Asp 
        115                 120                 125             


Gly Tyr Ile Ser Gln Gly Gly Phe Ala Ser His Val Arg Leu His Glu 
    130                 135                 140                 


His Phe Ala Ile Gln Ile Pro Glu Asn Ile Pro Ser Pro Leu Ala Ala 
145                 150                 155                 160 


Pro Leu Leu Cys Gly Gly Ile Thr Val Phe Ser Pro Leu Leu Arg Asn 
                165                 170                 175     


Gly Cys Gly Pro Gly Lys Arg Val Gly Ile Val Gly Ile Gly Gly Ile 
            180                 185                 190         


Gly His Met Gly Ile Leu Leu Ala Lys Ala Met Gly Ala Glu Val Tyr 
        195                 200                 205             


Ala Phe Ser Arg Gly His Ser Lys Arg Glu Asp Ser Met Lys Leu Gly 
    210                 215                 220                 


Ala Asp His Tyr Ile Ala Met Leu Glu Asp Lys Gly Trp Thr Glu Gln 
225                 230                 235                 240 


Tyr Ser Asn Ala Leu Asp Leu Leu Val Val Cys Ser Ser Ser Leu Ser 
                245                 250                 255     


Lys Val Asn Phe Asp Ser Ile Val Lys Ile Met Lys Ile Gly Gly Ser 
            260                 265                 270         


Ile Val Ser Ile Ala Ala Pro Glu Val Asn Glu Lys Leu Val Leu Lys 
        275                 280                 285             


Pro Leu Gly Leu Met Gly Val Ser Ile Ser Ser Ser Ala Ile Gly Ser 
    290                 295                 300                 


Arg Lys Glu Ile Glu Gln Leu Leu Lys Leu Val Ser Glu Lys Asn Val 
305                 310                 315                 320 


Lys Ile Trp Val Glu Lys Leu Pro Ile Ser Glu Glu Gly Val Ser His 
                325                 330                 335     


Ala Phe Thr Arg Met Glu Ser Gly Asp Val Lys Tyr Arg Phe Thr Leu 
            340                 345                 350         


Val Asp Tyr Asp Lys Lys Phe His Lys 
        355                 360     


