                         SEQUENCE LIST

<110>  DECARO NICOLA, MARTELLA VITO, ELIA GABRIELLA, BUONAVOGLIA CANIO
 
<120>  Canine coronavirus vaccine

<130>  9397MEUR

<160>  16    

<170>  PatentIn version 3.4

<210>  1
<211>  8618
<212>  DNA
<213>  Canine coronavirus

<400>  1
actaaacttt ggtaatcatt tagttaatgt gccatgattg tgatcttaac ttgcgtctta     60

ttgttgtgct cgtaccatac tgttgcgagt acgacaaata atgattgtag acaagttaac    120

gtaacacaat tagatggcaa cgaaaatctc attagagact ttttgtttca aaactttaaa    180

gaagaaggaa ctgtagttgt tggtggctat tatcctacag aggtgtggta caactgttct    240

agaacagcaa ctaccactgc ctatgagtat tttaataaca tacatgcatt ttattttgat    300

atggaagcca tggaaaatag cactggtaat gcacgtggta aaccgttatt gtttcatgtt    360

catggtgagc ctgttagtgc tatcatatat atatcggctt ataaaaatga tgtacaacac    420

aggccacttt taaaacatgg gttagtgtgc ataactaaaa ctcgcaatat tgactataac    480

agcttcacta gcagccagtg gaattccata tgtacaggta atgacagaaa aattcctttc    540

tctgtcatac ccacggacaa tggaacaaaa atctatggac ttgagtggaa tgacgaattt    600

gttacagcct atattagtgg tcattcttat aattggaaca tcaataataa ttggtttaac    660

aatgttacac tactttattc ccgctcaagt actgctacat ggcaacacag tgctgcatat    720

gtttaccaag gtgtttctaa cttcacttat tacaagttaa ataacaccaa tggtttaaaa    780

acttatgaat tttgtgatga ttatgaatat tgcactggct acgctactaa tgtctttgct    840

cccactgtag gaggttacat acctgatgga tttagtttta acaattggtt tttgcttaca    900

aatggctcca cttttgttag tggcagattt gtaacaaatc aaccattatt agttaattgt    960

ttatggccag tgcccagttt tggtgtggca gcacaagaat tttgttttga aggtgcgcag   1020

tttagtcagt gcaatggtgt gtctttaaat aacacagtgg atgttattag attcaatctt   1080

aattttaccg cagatgtaca atctggcatg ggtgctacag tgttctcatt gaatacaaca   1140

ggtggtgtca ttcttgaaat tttatgttat aatgacacag tgagtgagtc tagtttttac   1200

agttatggtg aaattccatt tggcataact gatggaccac ggtactgtta tgtactttac   1260

aatggcacag ctcttaagta tttaggaaca ttaccaccta gtgtaaagga aattgctatt   1320

agtaagtggg gccattttta tattaatggt tacaatttct ttagcacatt tcctattgat   1380

tgtatatctt ttaatttaac cactggtact agtggagctt tttggactat tgcttacaca   1440

tcgtacactg aagcattagt acaagttgaa aacacagcta ttaaaaaggt gacgtattgt   1500

aacagtcaca ttaataacat taaatgttct caacttactg ctaatttgca aaatggtttt   1560

tatcctgttg cttcaagtga agttggtctt gtcaataaga gtgttgtgtt actacctagt   1620

ttctattcac ataccagtgt taatataact attgatcttg gtatgaagcg tagtggttat   1680

ggtcaaccta tagcctcagc attaagtaac atcacactac cgatgcagga taataacacc   1740

gatgtgtatt gcattcgttc taatcaattt tcagtttacg tgcattccac ttgtaaaagt   1800

tctttatggg acaatgtgtt taattctgac tgcacagatt ttttacatgc tatagctgtt   1860

ataaaaactg gtacttgtcc tttctcattt gataaattga acaattacct aacttttaac   1920

aagttctgtt tttcattgaa tcctgttggt gccaattgca aatttgatgt tgctgcccgt   1980

acaagaacca atgagcaggt tgttagaagt ttatatgtga tatatgaaga aggagacaat   2040

atagtgggtg taccgtctga taatagtggt ctgcacgatt tgtcagtgtt acacttagac   2100

tcctgtacag attacaatat atatggtaga actggtgttg gtattattag acaaactaac   2160

agcacactac ttagtggctt atattacaca tcactatcag gtgatttgtt aggttttaaa   2220

aatgtcactg acggtgttgt ctattctgta acaccatgtg atgtaagtgc acaagctgct   2280

gttattgatg gtgccatagt tggagctatg acttccatta atagtgaact gttaggtcta   2340

actcattgga caacaacacc taatttttat tattactcca tatataatta tacaaatgcg   2400

agaactcgtg gcactgcaat cgacagtaac gatgttgatt gtgaacctat cataacctat   2460

tctaatatag gtgtttgtaa aaatggagct ttggttttta ttaacgtcac acattctgat   2520

ggtgacgttc aaccaattag caccggtaat gtcacgatac ctacaaattt tactatatct   2580

gtgcaagtcg aatatattca ggtttacact acaccagtgt caatagactg ttcaagatac   2640

gtctgcaatg gtaatcctag atgcaataaa ttgttaacac aatatgtctc tgcatgtcaa   2700

actattgagc aagcacttgc aatgggtgcc agacttgaaa acatggaagt tgattccatg   2760

ttgtttgttt ctgaaaatgc ccttaaattg gcatctgttg aagcattcaa tagtacggaa   2820

actctagatc ctatttacaa agaatggcct aacattggtg gttcttggct aggaggttta   2880

aaagacatat tgccatctca caatagcaaa cgtaagtacc ggtctgctat agaagatttg   2940

ctttttgata aggttgtgac atctggctta ggtacagtcg atgaagatta caaacgttgt   3000

acgggtggct atgacatagc tgacttagtg tgtgcacaat attacaatgg catcatggtg   3060

ttacctggtg tggctaatga tgacaagatg gctatgtaca ctgcatctct tgcaggtggt   3120

ataacattag gtgcacttgg tggtggtgca gtgtctatac cttttgcagt agcagttcag   3180

gctagactta attatgtagc tttacaaact gacgtattga acaaaaacca gcagattctg   3240

gctaatgctt tcaatcaagc gattggtaac attacacagg catttggtaa ggttaatgat   3300

gctatacatc aaacgtcaaa aggtcttgct actgttgcta aagcattggc aaaagtgcaa   3360

gatgttgtta acacacaagg gcaagcttta agccacctaa cagtacaatt gcaaaataat   3420

tttcaagcca ttagtagttc cattagtgac atttataaca ggcttgatga gttgagtgcg   3480

gatgcacaag ttgacaggct gattacagga cgacttacag cacttaatgc atttgtgtct   3540

cagactttaa ccagacaagc agaggttagg gctagtagac aacttgctaa agacaaagtt   3600

aatgaatgcg ttaggtctca atcccaaaga tttggattct gtggtaatgg tacacatttg   3660

ttttcacttg caaatgcagc accaaatggc atgattttct ttcacacagt gctattacca   3720

acagcttatg aaactgtgac ggcctggtca ggtatttgtg catcagatgg cgatcgcact   3780

tttggacttg ttgttaaaga tgtccagctg acgctatttc gcaatttaga tgacaaattc   3840

tatttgacac ctagaactat gtatcagcct agagttgcaa ctagttctga ttttgttcaa   3900

attgaagggt gtgatgtctt gtttgtcaat gcaactgtaa ttgagttgcc tagtattata   3960

cctgattata tcgatattaa tcagactgtt caagacatat tagaaaatta cagaccaaat   4020

tggacagtac ctgaattaac acttgacatt ttcaacgcaa cctacttaaa cctgactggt   4080

gaaattaatg acttagaatt caggtcagaa aagctacata acaccacggt agaacttgct   4140

gttctcattg acaatattaa caatacatta gtcaatcttg aatggctcaa tagaattgaa   4200

acttatgtaa aatggccttg gtatgtatgg ctactaatag gcttagtagt aatattttgc   4260

ataccattac tgctattttg ctgttgtagt acaggttgct gtgggtgcat aggttgctta   4320

ggaagttgtt gtcactctat ttgtagtaga agacaatttg aaaattatga accaattgag   4380

aaagtgcatg tccattaaat tcaaaataaa tctcttaaga actaaactta tgagtcatta   4440

caggtcttgt atggacattg tcaaatctat tgacacatcc gtagacgctg tacttgacga   4500

acttgatcgt gcatactttg ctgtaactct taaagtagag tttaagactg gtaaactact   4560

tgtgtgtata ggttttggtg atacacctct tgaggctaag gataaagcat atgctaaact   4620

tggtttctct attattgaag aagtcaatag tcatacagtt gtttgatatt accttttgaa   4680

actagacttc ttatcatcga acaaacaaaa cctaaagcat taagtgctac aaaacaatca   4740

aagagagatt atagaaaaat tgccattcta aattccatga gaaaatgatt ggtggacttt   4800

ttcttatttc tagctttgta ccgtagtaca aactttaaga cgtgtgtcgg tatcttaatg   4860

tttaagattg tatcaatgac acttataggg cctatgctta tagcatatgg ttactacatt   4920

gatggcattg ttacaacaac tgtcttagct ttaagatttg tctacttatc atacttttgg   4980

tatgttaata gtaggtttga attcatctta tacaatacaa cgacactcat gtttgtacat   5040

ggcagagctg caccgtttat gagaagttct cacagctcta tttatgtcac attgtacggt   5100

ggcataaatt atatgtttgt gaatgacctc acgttgcatt ttgtagaccc tatgcttgta   5160

agcatagcaa tacgtggctt agctcatgct gatctaactg ttgttagagc agttgaactt   5220

ctcaatggtg attttatcta tgtattttca caggagcccg tagtcggtgt ttacaatgca   5280

gccttttctc aggcggttct aaacgaaatt gacttaaaag aagaagaaga agaccatacc   5340

tatgacgttc cctagggcat tgactgtcat agatgacaat ggaatggtca ttagtatcat   5400

tttctggttc ctgttgataa ttatattgat attactttca atagcattgc taaatataat   5460

taagctatgc atggtatgtt gtaacttagg aagaacagtt attattgttc cagcgcaaca   5520

tgcctatgat gcctataaga attttatgcg aattaaagca tataaccccg acgaagcact   5580

ccttgtttga actaaacaaa atgaagattt tgttagtatt agcgtgtgca attgcatgcg   5640

catgtggtga acgttattgc gctatgaaat ctgactcaga tacttcgtgt cgcaatggta   5700

ccactactga ttgcgaatca tgcttcaacg gaggtgatct tatttggcat cttgcaaact   5760

ggaacttcag ctggtctgta atattgatcg tttttataac ggttttacaa tatggtagac   5820

ctcaatttag ctggttcgtg tatggcatta aaatgcttat tatgtggcta ctatggccca   5880

ttgttctggc tcttacgatt tttaatgcat actcggaata cgaagcttcc agatatgtaa   5940

tgttcggctt tagtgttgca ggtgcaattg ttacatttat actttggatt atgtattttg   6000

ttagatccat tcagttatac agaaggacta agtcttggtg gtctttcaac cctgaaacta   6060

acgcaattct ttgcgttagt gcattaggaa ggagctatgt gcttcctctt gaaggtgtgc   6120

caactggtgt cactttaaca ttgctctcag ggaatttgta cgctgaaggg ttcaaaattg   6180

caggtggtat gaacatcgac aatttgccaa agtacgtaat ggttgcatta cctagcagga   6240

ccattgtcta cacacttgtt ggtaagaaat tgaaagcaag tagtgcaaca ggatgggctt   6300

actatgtaaa atctaaagct ggtgattact caacagatgc acgaactgac aatttgagtg   6360

agcaagaaaa attattacat atggtataac taaacttcta aatgaccaac cagggacaac   6420

gcgttagctg gggagatgaa tctaccaaaa agcgtggtcg ttccaattct cgtggccgga   6480

agaataatac tatacctctt tcattcttca accccattac cctccaacaa ggttcaaaat   6540

tttggaactt atgtccgaga gactttgtac ccaaaggaat aggtaacaag gatcaacaga   6600

ttggttattg gaatagacaa actcgctatc gcatggtgaa gggtcagcgt aaagagcttc   6660

ctgaaaggtg gttcttctac tatttaggta ctggtcctca cgccgatgct aaatttaaag   6720

atagaataga tggagttgtc tgggttgcca aggatggtgc catgaataag ccaaccacac   6780

ttggtaatcg tggtgctaat aatgaatcca aagctttgaa attcgatggt aaagtaccag   6840

tagaatttca acttgaagtg aaccaatcaa gggacaattc aaggtcacgc tctcaatcta   6900

gatcccagtc tagaaataga tctcaatcta gaggaaggca acaatccaat aacaagaagg   6960

atgacagtgt agaacaagct gttcttgctg cactcaaaaa gttaggtgtt gacacagaaa   7020

aacaacaaca acgctctcgt tctaaatcca aggaacgtag caactctaag acaagagaca   7080

ctacacctaa gaatgaaaac aaacacacct ggaagagaac tgcaggtaaa ggtgatgtga   7140

caaaatttta tggagctaga agtagttcag ccaattttgg tgacagcgat ctcgttgcca   7200

atggtagcgg tgccaagcat tacccacaac tggctgaatg tgttccatct gtatctagca   7260

ttctgtttgg aagctattgg actgcaaagg aagatggcga ccagattgaa gtcacattca   7320

cacataaata ccacttgcca aaagatgatc ctaagactgg acaattcctt cagcagatta   7380

atgcctatgc tcgtccatca gaggtggcaa aagaacagag acaacgcaaa gctcgttcta   7440

aatctgcaga aaggtcagag caagaggttg tacctgatgc attaacagaa aattacacag   7500

atgtgtttga tgacacacag gttgagatta ttgatgaggt aacgaactaa acgaatgctc   7560

gttttcctcc atgctgtatt tatcacagtt ttaatcttac tactaattgg tagactccaa   7620

ttattagaaa gattattact taatcattcc ctcaatctta aaactgtcaa taatgtttta   7680

ggtgtgactg acactggtct gaaagtaaat tgcttacagc ttttgaaacc agactgtctt   7740

gattttaaca tcttacatag gagtttggca gaaaccagat tactaaaagt agtacttcga   7800

gtaatctttc tagtattact agggttttgc tgctacagat tgttagtcac attaatttag   7860

catcatgaag tttttgattt ttgtactgtg tctttctctt gtgaatggat atggaattag   7920

aagaagcata caagaacatg acccaaaaga gtcccatgaa cacccgacca tgacatggga   7980

attattggaa agatttgttg gaagtacctt gtacatcaca acaaaccaaa tcctatctct   8040

accaactgga gcgcaaattt attgtgatga gattgaagga ttccaatgct cttggcctgg   8100

ttataaagct tatgctcatg atcacattga ttatcatttt gatctttcca acccgttcta   8160

ttcttttgta aatacattct acatttcttt aggtgataga aaagaaaaaa tttatcttag   8220

agtggttggt gcaacaccaa aagagaaaag attgaatgtt ggttgtagaa catctttctc   8280

agttaacatg ccaattggaa ctcagattta ccatgacaaa gatatgcaat atcttgtcga   8340

gggaagacat cttgagtgtg ctcacagagt ttactttgtg aagtactgtc caaaccatgc   8400

acatggttac tgctttaatg acaggctaaa ggtttataat cttggtcgtg tcaaaagcag   8460

aaaggctttt gagaaaatca accaacatca gaaaagtgag ttgtaaggca acccgatgtt   8520

taaaactggt ttttccgagg aattactggt catcgcgctg tctactcttg tacagaatgg   8580

taagcacgtg taataggagg tacaagcaac cctattgc                           8618


<210>  2
<211>  1454
<212>  PRT
<213>  Canine coronavirus

<400>  2

Met Ile Val Ile Leu Thr Cys Val Leu Leu Leu Cys Ser Tyr His Thr 
1               5                   10                  15      


Val Ala Ser Thr Thr Asn Asn Asp Cys Arg Gln Val Asn Val Thr Gln 
            20                  25                  30          


Leu Asp Gly Asn Glu Asn Leu Ile Arg Asp Phe Leu Phe Gln Asn Phe 
        35                  40                  45              


Lys Glu Glu Gly Thr Val Val Val Gly Gly Tyr Tyr Pro Thr Glu Val 
    50                  55                  60                  


Trp Tyr Asn Cys Ser Arg Thr Ala Thr Thr Thr Ala Tyr Glu Tyr Phe 
65                  70                  75                  80  


Asn Asn Ile His Ala Phe Tyr Phe Asp Met Glu Ala Met Glu Asn Ser 
                85                  90                  95      


Thr Gly Asn Ala Arg Gly Lys Pro Leu Leu Phe His Val His Gly Glu 
            100                 105                 110         


Pro Val Ser Ala Ile Ile Tyr Ile Ser Ala Tyr Lys Asn Asp Val Gln 
        115                 120                 125             


His Arg Pro Leu Leu Lys His Gly Leu Val Cys Ile Thr Lys Thr Arg 
    130                 135                 140                 


Asn Ile Asp Tyr Asn Ser Phe Thr Ser Ser Gln Trp Asn Ser Ile Cys 
145                 150                 155                 160 


Thr Gly Asn Asp Arg Lys Ile Pro Phe Ser Val Ile Pro Thr Asp Asn 
                165                 170                 175     


Gly Thr Lys Ile Tyr Gly Leu Glu Trp Asn Asp Glu Phe Val Thr Ala 
            180                 185                 190         


Tyr Ile Ser Gly His Ser Tyr Asn Trp Asn Ile Asn Asn Asn Trp Phe 
        195                 200                 205             


Asn Asn Val Thr Leu Leu Tyr Ser Arg Ser Ser Thr Ala Thr Trp Gln 
    210                 215                 220                 


His Ser Ala Ala Tyr Val Tyr Gln Gly Val Ser Asn Phe Thr Tyr Tyr 
225                 230                 235                 240 
Lys Leu Asn Asn Thr Asn Gly Leu Lys Thr Tyr Glu Phe Cys Asp Asp 
                245                 250                 255     


Tyr Glu Tyr Cys Thr Gly Tyr Ala Thr Asn Val Phe Ala Pro Thr Val 
            260                 265                 270         


Gly Gly Tyr Ile Pro Asp Gly Phe Ser Phe Asn Asn Trp Phe Leu Leu 
        275                 280                 285             


Thr Asn Gly Ser Thr Phe Val Ser Gly Arg Phe Val Thr Asn Gln Pro 
    290                 295                 300                 


Leu Leu Val Asn Cys Leu Trp Pro Val Pro Ser Phe Gly Val Ala Ala 
305                 310                 315                 320 


Gln Glu Phe Cys Phe Glu Gly Ala Gln Phe Ser Gln Cys Asn Gly Val 
                325                 330                 335     


Ser Leu Asn Asn Thr Val Asp Val Ile Arg Phe Asn Leu Asn Phe Thr 
            340                 345                 350         


Ala Asp Val Gln Ser Gly Met Gly Ala Thr Val Phe Ser Leu Asn Thr 
        355                 360                 365             


Thr Gly Gly Val Ile Leu Glu Ile Leu Cys Tyr Asn Asp Thr Val Ser 
    370                 375                 380                 


Glu Ser Ser Phe Tyr Ser Tyr Gly Glu Ile Pro Phe Gly Ile Thr Asp 
385                 390                 395                 400 


Gly Pro Arg Tyr Cys Tyr Val Leu Tyr Asn Gly Thr Ala Leu Lys Tyr 
                405                 410                 415     


Leu Gly Thr Leu Pro Pro Ser Val Lys Glu Ile Ala Ile Ser Lys Trp 
            420                 425                 430         


Gly His Phe Tyr Ile Asn Gly Tyr Asn Phe Phe Ser Thr Phe Pro Ile 
        435                 440                 445             


Asp Cys Ile Ser Phe Asn Leu Thr Thr Gly Thr Ser Gly Ala Phe Trp 
    450                 455                 460                 


Thr Ile Ala Tyr Thr Ser Tyr Thr Glu Ala Leu Val Gln Val Glu Asn 
465                 470                 475                 480 


Thr Ala Ile Lys Lys Val Thr Tyr Cys Asn Ser His Ile Asn Asn Ile 
                485                 490                 495     
Lys Cys Ser Gln Leu Thr Ala Asn Leu Gln Asn Gly Phe Tyr Pro Val 
            500                 505                 510         


Ala Ser Ser Glu Val Gly Leu Val Asn Lys Ser Val Val Leu Leu Pro 
        515                 520                 525             


Ser Phe Tyr Ser His Thr Ser Val Asn Ile Thr Ile Asp Leu Gly Met 
    530                 535                 540                 


Lys Arg Ser Gly Tyr Gly Gln Pro Ile Ala Ser Ala Leu Ser Asn Ile 
545                 550                 555                 560 


Thr Leu Pro Met Gln Asp Asn Asn Thr Asp Val Tyr Cys Ile Arg Ser 
                565                 570                 575     


Asn Gln Phe Ser Val Tyr Val His Ser Thr Cys Lys Ser Ser Leu Trp 
            580                 585                 590         


Asp Asn Val Phe Asn Ser Asp Cys Thr Asp Phe Leu His Ala Ile Ala 
        595                 600                 605             


Val Ile Lys Thr Gly Thr Cys Pro Phe Ser Phe Asp Lys Leu Asn Asn 
    610                 615                 620                 


Tyr Leu Thr Phe Asn Lys Phe Cys Phe Ser Leu Asn Pro Val Gly Ala 
625                 630                 635                 640 


Asn Cys Lys Phe Asp Val Ala Ala Arg Thr Arg Thr Asn Glu Gln Val 
                645                 650                 655     


Val Arg Ser Leu Tyr Val Ile Tyr Glu Glu Gly Asp Asn Ile Val Gly 
            660                 665                 670         


Val Pro Ser Asp Asn Ser Gly Leu His Asp Leu Ser Val Leu His Leu 
        675                 680                 685             


Asp Ser Cys Thr Asp Tyr Asn Ile Tyr Gly Arg Thr Gly Val Gly Ile 
    690                 695                 700                 


Ile Arg Gln Thr Asn Ser Thr Leu Leu Ser Gly Leu Tyr Tyr Thr Ser 
705                 710                 715                 720 


Leu Ser Gly Asp Leu Leu Gly Phe Lys Asn Val Thr Asp Gly Val Val 
                725                 730                 735     


Tyr Ser Val Thr Pro Cys Asp Val Ser Ala Gln Ala Ala Val Ile Asp 
            740                 745                 750         
Gly Ala Ile Val Gly Ala Met Thr Ser Ile Asn Ser Glu Leu Leu Gly 
        755                 760                 765             


Leu Thr His Trp Thr Thr Thr Pro Asn Phe Tyr Tyr Tyr Ser Ile Tyr 
    770                 775                 780                 


Asn Tyr Thr Asn Ala Arg Thr Arg Gly Thr Ala Ile Asp Ser Asn Asp 
785                 790                 795                 800 


Val Asp Cys Glu Pro Ile Ile Thr Tyr Ser Asn Ile Gly Val Cys Lys 
                805                 810                 815     


Asn Gly Ala Leu Val Phe Ile Asn Val Thr His Ser Asp Gly Asp Val 
            820                 825                 830         


Gln Pro Ile Ser Thr Gly Asn Val Thr Ile Pro Thr Asn Phe Thr Ile 
        835                 840                 845             


Ser Val Gln Val Glu Tyr Ile Gln Val Tyr Thr Thr Pro Val Ser Ile 
    850                 855                 860                 


Asp Cys Ser Arg Tyr Val Cys Asn Gly Asn Pro Arg Cys Asn Lys Leu 
865                 870                 875                 880 


Leu Thr Gln Tyr Val Ser Ala Cys Gln Thr Ile Glu Gln Ala Leu Ala 
                885                 890                 895     


Met Gly Ala Arg Leu Glu Asn Met Glu Val Asp Ser Met Leu Phe Val 
            900                 905                 910         


Ser Glu Asn Ala Leu Lys Leu Ala Ser Val Glu Ala Phe Asn Ser Thr 
        915                 920                 925             


Glu Thr Leu Asp Pro Ile Tyr Lys Glu Trp Pro Asn Ile Gly Gly Ser 
    930                 935                 940                 


Trp Leu Gly Gly Leu Lys Asp Ile Leu Pro Ser His Asn Ser Lys Arg 
945                 950                 955                 960 


Lys Tyr Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp Lys Val Val Thr 
                965                 970                 975     


Ser Gly Leu Gly Thr Val Asp Glu Asp Tyr Lys Arg Cys Thr Gly Gly 
            980                 985                 990         


Tyr Asp Ile Ala Asp Leu Val Cys  Ala Gln Tyr Tyr Asn  Gly Ile Met 
        995                 1000                 1005             
Val Leu  Pro Gly Val Ala Asn  Asp Asp Lys Met Ala  Met Tyr Thr 
    1010                 1015                 1020             


Ala Ser  Leu Ala Gly Gly Ile  Thr Leu Gly Ala Leu  Gly Gly Gly 
    1025                 1030                 1035             


Ala Val  Ser Ile Pro Phe Ala  Val Ala Val Gln Ala  Arg Leu Asn 
    1040                 1045                 1050             


Tyr Val  Ala Leu Gln Thr Asp  Val Leu Asn Lys Asn  Gln Gln Ile 
    1055                 1060                 1065             


Leu Ala  Asn Ala Phe Asn Gln  Ala Ile Gly Asn Ile  Thr Gln Ala 
    1070                 1075                 1080             


Phe Gly  Lys Val Asn Asp Ala  Ile His Gln Thr Ser  Lys Gly Leu 
    1085                 1090                 1095             


Ala Thr  Val Ala Lys Ala Leu  Ala Lys Val Gln Asp  Val Val Asn 
    1100                 1105                 1110             


Thr Gln  Gly Gln Ala Leu Ser  His Leu Thr Val Gln  Leu Gln Asn 
    1115                 1120                 1125             


Asn Phe  Gln Ala Ile Ser Ser  Ser Ile Ser Asp Ile  Tyr Asn Arg 
    1130                 1135                 1140             


Leu Asp  Glu Leu Ser Ala Asp  Ala Gln Val Asp Arg  Leu Ile Thr 
    1145                 1150                 1155             


Gly Arg  Leu Thr Ala Leu Asn  Ala Phe Val Ser Gln  Thr Leu Thr 
    1160                 1165                 1170             


Arg Gln  Ala Glu Val Arg Ala  Ser Arg Gln Leu Ala  Lys Asp Lys 
    1175                 1180                 1185             


Val Asn  Glu Cys Val Arg Ser  Gln Ser Gln Arg Phe  Gly Phe Cys 
    1190                 1195                 1200             


Gly Asn  Gly Thr His Leu Phe  Ser Leu Ala Asn Ala  Ala Pro Asn 
    1205                 1210                 1215             


Gly Met  Ile Phe Phe His Thr  Val Leu Leu Pro Thr  Ala Tyr Glu 
    1220                 1225                 1230             


Thr Val  Thr Ala Trp Ser Gly  Ile Cys Ala Ser Asp  Gly Asp Arg 
    1235                 1240                 1245             
Thr Phe  Gly Leu Val Val Lys  Asp Val Gln Leu Thr  Leu Phe Arg 
    1250                 1255                 1260             


Asn Leu  Asp Asp Lys Phe Tyr  Leu Thr Pro Arg Thr  Met Tyr Gln 
    1265                 1270                 1275             


Pro Arg  Val Ala Thr Ser Ser  Asp Phe Val Gln Ile  Glu Gly Cys 
    1280                 1285                 1290             


Asp Val  Leu Phe Val Asn Ala  Thr Val Ile Glu Leu  Pro Ser Ile 
    1295                 1300                 1305             


Ile Pro  Asp Tyr Ile Asp Ile  Asn Gln Thr Val Gln  Asp Ile Leu 
    1310                 1315                 1320             


Glu Asn  Tyr Arg Pro Asn Trp  Thr Val Pro Glu Leu  Thr Leu Asp 
    1325                 1330                 1335             


Ile Phe  Asn Ala Thr Tyr Leu  Asn Leu Thr Gly Glu  Ile Asn Asp 
    1340                 1345                 1350             


Leu Glu  Phe Arg Ser Glu Lys  Leu His Asn Thr Thr  Val Glu Leu 
    1355                 1360                 1365             


Ala Val  Leu Ile Asp Asn Ile  Asn Asn Thr Leu Val  Asn Leu Glu 
    1370                 1375                 1380             


Trp Leu  Asn Arg Ile Glu Thr  Tyr Val Lys Trp Pro  Trp Tyr Val 
    1385                 1390                 1395             


Trp Leu  Leu Ile Gly Leu Val  Val Ile Phe Cys Ile  Pro Leu Leu 
    1400                 1405                 1410             


Leu Phe  Cys Cys Cys Ser Thr  Gly Cys Cys Gly Cys  Ile Gly Cys 
    1415                 1420                 1425             


Leu Gly  Ser Cys Cys His Ser  Ile Cys Ser Arg Arg  Gln Phe Glu 
    1430                 1435                 1440             


Asn Tyr  Glu Pro Ile Glu Lys  Val His Val His 
    1445                 1450                 


<210>  3
<211>  71
<212>  PRT
<213>  Canine coronavirus

<400>  3
Met Asp Ile Val Lys Ser Ile Asp Thr Ser Val Asp Ala Val Leu Asp 
1               5                   10                  15      


Glu Leu Asp Arg Ala Tyr Phe Ala Val Thr Leu Lys Val Glu Phe Lys 
            20                  25                  30          


Thr Gly Lys Leu Leu Val Cys Ile Gly Phe Gly Asp Thr Pro Leu Glu 
        35                  40                  45              


Ala Lys Asp Lys Ala Tyr Ala Lys Leu Gly Phe Ser Ile Ile Glu Glu 
    50                  55                  60                  


Val Asn Ser His Thr Val Val 
65                  70      


<210>  4
<211>  22
<212>  PRT
<213>  Canine coronavirus

<400>  4

Met Leu Asn Leu Val Ser Leu Leu Leu Lys Lys Ser Ile Val Ile Gln 
1               5                   10                  15      


Leu Phe Asp Ile Thr Phe 
            20          


<210>  5
<211>  13
<212>  PRT
<213>  Canine coronavirus

<400>  5

Met Ile Gly Gly Leu Phe Leu Ile Ser Ser Phe Val Pro 
1               5                   10              


<210>  6
<211>  82
<212>  PRT
<213>  Canine coronavirus

<400>  6

Met Thr Phe Pro Arg Ala Leu Thr Val Ile Asp Asp Asn Gly Met Val 
1               5                   10                  15      


Ile Ser Ile Ile Phe Trp Phe Leu Leu Ile Ile Ile Leu Ile Leu Leu 
            20                  25                  30          


Ser Ile Ala Leu Leu Asn Ile Ile Lys Leu Cys Met Val Cys Cys Asn 
        35                  40                  45              
Leu Gly Arg Thr Val Ile Ile Val Pro Ala Gln His Ala Tyr Asp Ala 
    50                  55                  60                  


Tyr Lys Asn Phe Met Arg Ile Lys Ala Tyr Asn Pro Asp Glu Ala Leu 
65                  70                  75                  80  


Leu Val 
        


<210>  7
<211>  262
<212>  PRT
<213>  Canine coronavirus

<400>  7

Met Lys Ile Leu Leu Val Leu Ala Cys Ala Ile Ala Cys Ala Cys Gly 
1               5                   10                  15      


Glu Arg Tyr Cys Ala Met Lys Ser Asp Ser Asp Thr Ser Cys Arg Asn 
            20                  25                  30          


Gly Thr Thr Thr Asp Cys Glu Ser Cys Phe Asn Gly Gly Asp Leu Ile 
        35                  40                  45              


Trp His Leu Ala Asn Trp Asn Phe Ser Trp Ser Val Ile Leu Ile Val 
    50                  55                  60                  


Phe Ile Thr Val Leu Gln Tyr Gly Arg Pro Gln Phe Ser Trp Phe Val 
65                  70                  75                  80  


Tyr Gly Ile Lys Met Leu Ile Met Trp Leu Leu Trp Pro Ile Val Leu 
                85                  90                  95      


Ala Leu Thr Ile Phe Asn Ala Tyr Ser Glu Tyr Glu Ala Ser Arg Tyr 
            100                 105                 110         


Val Met Phe Gly Phe Ser Val Ala Gly Ala Ile Val Thr Phe Ile Leu 
        115                 120                 125             


Trp Ile Met Tyr Phe Val Arg Ser Ile Gln Leu Tyr Arg Arg Thr Lys 
    130                 135                 140                 


Ser Trp Trp Ser Phe Asn Pro Glu Thr Asn Ala Ile Leu Cys Val Ser 
145                 150                 155                 160 


Ala Leu Gly Arg Ser Tyr Val Leu Pro Leu Glu Gly Val Pro Thr Gly 
                165                 170                 175     

Val Thr Leu Thr Leu Leu Ser Gly Asn Leu Tyr Ala Glu Gly Phe Lys 
            180                 185                 190         


Ile Ala Gly Gly Met Asn Ile Asp Asn Leu Pro Lys Tyr Val Met Val 
        195                 200                 205             


Ala Leu Pro Ser Arg Thr Ile Val Tyr Thr Leu Val Gly Lys Lys Leu 
    210                 215                 220                 


Lys Ala Ser Ser Ala Thr Gly Trp Ala Tyr Tyr Val Lys Ser Lys Ala 
225                 230                 235                 240 


Gly Asp Tyr Ser Thr Asp Ala Arg Thr Asp Asn Leu Ser Glu Gln Glu 
                245                 250                 255     


Lys Leu Leu His Met Val 
            260         


<210>  8
<211>  382
<212>  PRT
<213>  Canine coronavirus

<400>  8

Met Thr Asn Gln Gly Gln Arg Val Ser Trp Gly Asp Glu Ser Thr Lys 
1               5                   10                  15      


Lys Arg Gly Arg Ser Asn Ser Arg Gly Arg Lys Asn Asn Thr Ile Pro 
            20                  25                  30          


Leu Ser Phe Phe Asn Pro Ile Thr Leu Gln Gln Gly Ser Lys Phe Trp 
        35                  40                  45              


Asn Leu Cys Pro Arg Asp Phe Val Pro Lys Gly Ile Gly Asn Lys Asp 
    50                  55                  60                  


Gln Gln Ile Gly Tyr Trp Asn Arg Gln Thr Arg Tyr Arg Met Val Lys 
65                  70                  75                  80  


Gly Gln Arg Lys Glu Leu Pro Glu Arg Trp Phe Phe Tyr Tyr Leu Gly 
                85                  90                  95      


Thr Gly Pro His Ala Asp Ala Lys Phe Lys Asp Arg Ile Asp Gly Val 
            100                 105                 110         


Val Trp Val Ala Lys Asp Gly Ala Met Asn Lys Pro Thr Thr Leu Gly 
        115                 120                 125             

Asn Arg Gly Ala Asn Asn Glu Ser Lys Ala Leu Lys Phe Asp Gly Lys 
    130                 135                 140                 


Val Pro Val Glu Phe Gln Leu Glu Val Asn Gln Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Arg Ser Arg Ser Gln Ser Arg Ser Gln Ser Arg Asn Arg Ser Gln Ser 
                165                 170                 175     


Arg Gly Arg Gln Gln Ser Asn Asn Lys Lys Asp Asp Ser Val Glu Gln 
            180                 185                 190         


Ala Val Leu Ala Ala Leu Lys Lys Leu Gly Val Asp Thr Glu Lys Gln 
        195                 200                 205             


Gln Gln Arg Ser Arg Ser Lys Ser Lys Glu Arg Ser Asn Ser Lys Thr 
    210                 215                 220                 


Arg Asp Thr Thr Pro Lys Asn Glu Asn Lys His Thr Trp Lys Arg Thr 
225                 230                 235                 240 


Ala Gly Lys Gly Asp Val Thr Lys Phe Tyr Gly Ala Arg Ser Ser Ser 
                245                 250                 255     


Ala Asn Phe Gly Asp Ser Asp Leu Val Ala Asn Gly Ser Gly Ala Lys 
            260                 265                 270         


His Tyr Pro Gln Leu Ala Glu Cys Val Pro Ser Val Ser Ser Ile Leu 
        275                 280                 285             


Phe Gly Ser Tyr Trp Thr Ala Lys Glu Asp Gly Asp Gln Ile Glu Val 
    290                 295                 300                 


Thr Phe Thr His Lys Tyr His Leu Pro Lys Asp Asp Pro Lys Thr Gly 
305                 310                 315                 320 


Gln Phe Leu Gln Gln Ile Asn Ala Tyr Ala Arg Pro Ser Glu Val Ala 
                325                 330                 335     


Lys Glu Gln Arg Gln Arg Lys Ala Arg Ser Lys Ser Ala Glu Arg Ser 
            340                 345                 350         


Glu Gln Glu Val Val Pro Asp Ala Leu Thr Glu Asn Tyr Thr Asp Val 
        355                 360                 365             


Phe Asp Asp Thr Gln Val Glu Ile Ile Asp Glu Val Thr Asn 
    370                 375                 380         
<210>  9
<211>  101
<212>  PRT
<213>  Canine coronavirus

<400>  9

Met Leu Val Phe Leu His Ala Val Phe Ile Thr Val Leu Ile Leu Leu 
1               5                   10                  15      


Leu Ile Gly Arg Leu Gln Leu Leu Glu Arg Leu Leu Leu Asn His Ser 
            20                  25                  30          


Leu Asn Leu Lys Thr Val Asn Asn Val Leu Gly Val Thr Asp Thr Gly 
        35                  40                  45              


Leu Lys Val Asn Cys Leu Gln Leu Leu Lys Pro Asp Cys Leu Asp Phe 
    50                  55                  60                  


Asn Ile Leu His Arg Ser Leu Ala Glu Thr Arg Leu Leu Lys Val Val 
65                  70                  75                  80  


Leu Arg Val Ile Phe Leu Val Leu Leu Gly Phe Cys Cys Tyr Arg Leu 
                85                  90                  95      


Leu Val Thr Leu Ile 
            100     


<210>  10
<211>  213
<212>  PRT
<213>  Canine coronavirus

<400>  10

Met Lys Phe Leu Ile Phe Val Leu Cys Leu Ser Leu Val Asn Gly Tyr 
1               5                   10                  15      


Gly Ile Arg Arg Ser Ile Gln Glu His Asp Pro Lys Glu Ser His Glu 
            20                  25                  30          


His Pro Thr Met Thr Trp Glu Leu Leu Glu Arg Phe Val Gly Ser Thr 
        35                  40                  45              


Leu Tyr Ile Thr Thr Asn Gln Ile Leu Ser Leu Pro Thr Gly Ala Gln 
    50                  55                  60                  


Ile Tyr Cys Asp Glu Ile Glu Gly Phe Gln Cys Ser Trp Pro Gly Tyr 
65                  70                  75                  80  


Lys Ala Tyr Ala His Asp His Ile Asp Tyr His Phe Asp Leu Ser Asn 
                85                  90                  95      


Pro Phe Tyr Ser Phe Val Asn Thr Phe Tyr Ile Ser Leu Gly Asp Arg 
            100                 105                 110         


Lys Glu Lys Ile Tyr Leu Arg Val Val Gly Ala Thr Pro Lys Glu Lys 
        115                 120                 125             


Arg Leu Asn Val Gly Cys Arg Thr Ser Phe Ser Val Asn Met Pro Ile 
    130                 135                 140                 


Gly Thr Gln Ile Tyr His Asp Lys Asp Met Gln Tyr Leu Val Glu Gly 
145                 150                 155                 160 


Arg His Leu Glu Cys Ala His Arg Val Tyr Phe Val Lys Tyr Cys Pro 
                165                 170                 175     


Asn His Ala His Gly Tyr Cys Phe Asn Asp Arg Leu Lys Val Tyr Asn 
            180                 185                 190         


Leu Gly Arg Val Lys Ser Arg Lys Ala Phe Glu Lys Ile Asn Gln His 
        195                 200                 205             


Gln Lys Ser Glu Leu 
    210             


<210>  11
<211>  23
<212>  DNA
<213>  Canine coronavirus

<400>  11
cgttagtgca cttggaagaa gct                                             23


<210>  12
<211>  22
<212>  DNA
<213>  Canine coronavirus

<400>  12
accagccatt ttaaatcctt ca                                              22


<210>  13
<211>  19
<212>  DNA
<213>  Canine coronavirus

<400>  13
cctcttgaag gtacaccaa                                                  19

<210>  14
<211>  20
<212>  DNA
<213>  Canine coronavirus

<400>  14
tagtgcatta ggaagaagct                                                 20


<210>  15
<211>  18
<212>  DNA
<213>  Canine coronavirus

<400>  15
agcaattttg aacccttc                                                   18


<210>  16
<211>  17
<212>  DNA
<213>  Canine coronavirus

<400>  16
cctcttgaag gtgtgcc                                                    17

1



