                         SEQUENCE LISTING

<110>  LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
       CROFT, Michael
       MADIREDDI, Shravan
 
<120>  MODULATORS OF 4-1BB AND IMMUNE RESPONSES

<130>  051501-0408909

<140>  PCT/US2012/43383
<141>  2012-06-20

<150>  61/499,052
<151>  2011-06-20

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  1

Pro Cys Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys 
1               5                   10                  15      


Asp Ile Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys 
            20                  25                  30          


Ser Ser Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys 
        35                  40                  45              


Leu Gly Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln 
    50                  55                  60                  


Glu Leu Thr Lys Lys Gly Cys Lys Asp Cys 
65                  70                  


<210>  2
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys 
            20          


<210>  3
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Cys Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys 
1               5                   10                  15      


Asp Ile Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys 
            20                  25                  30          


Ser Ser Thr Ser Asn Ala Glu Cys 
        35                  40  


<210>  4
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys 
1               5                   10                  15      


Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys 
            20                  25                  30          


<210>  5
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg 
1               5                   10                  15      


Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly 
            20                  25                  30          


Thr Lys Glu Arg Asp Val Val Cys Gly 
        35                  40      


<210>  6
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile 
1               5                   10                  15      


Thr Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val 
            20                  25                  30          


Asn Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn 
        35                  40                  45              


Pro Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn 
    50                  55                  60                  


Gly Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys 
65                  70                  75                  80  


Gly Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys 
                85                  90                  95      


Val Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro 
            100                 105                 110         


Phe His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser 
        115                 120                 125             


Tyr Ile Ser 
    130     


<210>  7
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser Ile Leu 
1               5                   10                  15      


Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile Asn Leu 
            20                  25                  30          


Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe Asp Glu 
        35                  40                  45              


Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly Ser Glu 
    50                  55                  60                  


Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln Ser Phe 
65                  70                  75                  80  


Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala Val Asp 
                85                  90                  95      


Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu Pro Thr 
            100                 105                 110         


Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His Val Gln 
        115                 120                 125             


<210>  8
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  8

Pro Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile 
1               5                   10                  15      


Thr Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val 
            20                  25                  30          


Asn Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn 
        35                  40                  45              


Pro Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn 
    50                  55                  60                  


Gly Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys 
65                  70                  75                  80  


Gly Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys 
                85                  90                  95      


Val Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro 
            100                 105                 110         


Phe His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser 
        115                 120                 125             


Tyr Ile Ser 
    130     


<210>  9
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser Ile Leu 
1               5                   10                  15      


Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile Asn Leu 
            20                  25                  30          


Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe Asp Glu 
        35                  40                  45              


Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly Ser Glu 
    50                  55                  60                  


Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln Ser Phe 
65                  70                  75                  80  


Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Val Ala Val Asp Gly 
                85                  90                  95      


Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu Pro Thr Ile 
            100                 105                 110         


Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His Val Gln 
        115                 120                 125         


<210>  10
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  11
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr 
        355 


<210>  12
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys 
            20          


<210>  13
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  13

Pro Cys Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys 
1               5                   10                  15      


Asp Ile Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys 
            20                  25                  30          


Ser Ser Thr Ser Asn Ala Glu Cys 
        35                  40  


<210>  14
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys 
1               5                   10                  15      


Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys 
            20                  25                  30          


<210>  15
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg 
1               5                   10                  15      


Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly 
            20                  25                  30          


Thr Lys Glu Arg Asp Val Val Cys Gly 
        35                  40      


<210>  16
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile 
1               5                   10                  15      


Thr Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val 
            20                  25                  30          


Asn Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn 
        35                  40                  45              


Pro Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn 
    50                  55                  60                  


Gly Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys 
65                  70                  75                  80  


Gly Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys 
                85                  90                  95      


Val Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro 
            100                 105                 110         


Phe His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser 
        115                 120                 125             


Tyr Ile Ser 
    130     


<210>  17
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  17

Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser Ile Leu 
1               5                   10                  15      


Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile Asn Leu 
            20                  25                  30          


Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe Asp Glu 
        35                  40                  45              


Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly Ser Glu 
    50                  55                  60                  


Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln Ser Phe 
65                  70                  75                  80  


Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala Val Asp 
                85                  90                  95      


Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu Pro Thr 
            100                 105                 110         


Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His Val Gln 
        115                 120                 125             


<210>  18
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  19
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg 
65                  70                  75                  80  


Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile 
                85                  90                  95      


Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln 
            100                 105                 110         


Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile 
        115                 120                 125             


Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr 
    130                 135                 140                 


Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu 
145                 150                 155                 160 


Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser 
                165                 170                 175     


Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg 
            180                 185                 190         


Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly Ile 
        195                 200                 205             


Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe Lys 
    210                 215                 220                 


Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile Ser 
225                 230                 235                 240 


Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu Gly 
                245                 250                 255     


Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr Glu 
            260                 265                 270         


Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln Gln 
        275                 280                 285             


Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300 


<210>  20
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Glu Ala Ser Lys 
    690                 695                 700                 


Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro 
705                 710                 715                 720 


Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp 
                725                 730                 735     


Met Lys Ile Gly Val 
            740     


<210>  21
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr 
    210                 215                 220                 


Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 


Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     


Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 
            260                 265                 270         


Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 
        275                 280                 285             


Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val 
    290                 295                 300                 


Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala 
305                 310                 315                 320 


His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro 
                325                 330                 335     


His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu 
            340                 345                 350         


Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly 
        355                 360                 365             


Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala 
    370                 375                 380                 


Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
385                 390                 395                 400 


Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         


Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
        435                 440                 445             


Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
    450                 455                 460                 


Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 


Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 
                485                 490                 495     


Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 
            500                 505                 510         


Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 
        515                 520                 525             


Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 
    530                 535                 540                 


Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 


Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 
                565                 570                 575     


Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         


Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             


Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 


Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 


Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     


Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         


Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 
        675                 680                 685             


Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 


<210>  22
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met 
    210                 215                 220                 


Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr 
225                 230                 235                 240 


Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr 
                245                 250                 255     


Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu 
            260                 265                 270         


Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg 
        275                 280                 285             


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
    290                 295                 300                 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
305                 310                 315                 320 


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
                325                 330                 335     


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
            340                 345                 350         


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
        355                 360                 365             


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
    370                 375                 380                 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
385                 390                 395                 400 


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
                405                 410                 415     


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
            420                 425                 430         


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
        435                 440                 445             


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
    450                 455                 460                 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
465                 470                 475                 480 


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
                485                 490             


<210>  23
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
    290                 295                 300                 


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
305                 310                 315                 320 


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
                325                 330                 335     


Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 
            340                 345                 350         


Gln Asn Val Asp Met Lys Ile Gly Val 
        355                 360     


<210>  24
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Leu His 
65                  70                  75                  80  


Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp 
                85                  90                  95      


Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Thr Gln 
            100                 105                 110         


Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly 
        115                 120                 125             


Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser 
    130                 135                 


<210>  25
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Arg 
    210                 215                 220                 


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
225                 230                 235                 240 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
                245                 250                 255     


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
            260                 265                 270         


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
        275                 280                 285             


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
    290                 295                 300                 


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
305                 310                 315                 320 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
                325                 330                 335     


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
            340                 345                 350         


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
        355                 360                 365             


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
    370                 375                 380                 


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
385                 390                 395                 400 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
                405                 410                 415     


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
            420                 425                 


<210>  26
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg His 
    210                 215                 220                 


Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile 
225                 230                 235                 240 


Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu 
                245                 250                 255     


Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg 
            260                 265                 270         


Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala 
        275                 280                 285             


Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser 
    290                 295                 300                 


Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp 
305                 310                 315                 320 


Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met 
                325                 330                 335     


Lys Ile Gly Val 
            340 


<210>  27
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Ser 
    290                 


<210>  28
<211>  6001
<212>  DNA
<213>  Homo sapiens

<400>  28
caaggaggga tcccacagat gtcacagggc tgtcacagag ctgtggtggg aatttcccat       60

gagaccccgc ccctggctga gtcaccgcac tcctgtgttt gacctgaagt cctctcgagc      120

tgcagaagcc tgaagaccaa ggagtggaaa gttctccggc agccctgaga tctcaagagt      180

gacatttgtg agaccagcta atttgattaa aattctcttg gaatcagctt tgctagtatc      240

atacctgtgc cagatttcat catgggaaac agctgttaca acatagtagc cactctgttg      300

ctggtcctca actttgagag gacaagatca ttgcaggatc cttgtagtaa ctgcccagct      360

ggtacattct gtgataataa caggaatcag atttgcagtc cctgtcctcc aaatagtttc      420

tccagcgcag gtggacaaag gacctgtgac atatgcaggc agtgtaaagg tgttttcagg      480

accaggaagg agtgttcctc caccagcaat gcagagtgtg actgcactcc agggtttcac      540

tgcctggggg caggatgcag catgtgtgaa caggattgta aacaaggtca agaactgaca      600

aaaaaaggtt gtaaagactg ttgctttggg acatttaacg atcagaaacg tggcatctgt      660

cgaccctgga caaactgttc tttggatgga aagtctgtgc ttgtgaatgg gacgaaggag      720

agggacgtgg tctgtggacc atctccagcc gacctctctc cgggagcatc ctctgtgacc      780

ccgcctgccc ctgcgagaga gccaggacac tctccgcaga tcatctcctt ctttcttgcg      840

ctgacgtcga ctgcgttgct cttcctgctg ttcttcctca cgctccgttt ctctgttgtt      900

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa      960

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1020

gaactgtgaa atggaagtca atagggctgt tgggactttc ttgaaaagaa gcaaggaaat     1080

atgagtcatc cgctatcaca gctttcaaaa gcaagaacac catcctacat aatacccagg     1140

attcccccaa cacacgttct tttctaaatg ccaatgagtt ggcctttaaa aatgcaccac     1200

tttttttttt tttttgacag ggtctcactc tgtcacccag gctggagtgc agtggcacca     1260

ccatggctct ctgcagcctt gacctctggg agctcaagtg atcctcctgc ctcagtctcc     1320

tgagtagctg gaactacaag gaagggccac cacacctgac taactttttt gttttttgtt     1380

tggtaaagat ggcatttcac catgttgtac aggctggtct caaactccta ggttcacttt     1440

ggcctcccaa agtgctggga ttacagacat gaactgccag gcccggccaa aataatgcac     1500

cacttttaac agaacagaca gatgaggaca gagctggtga taaaaaaaaa aaaaaaaaag     1560

cattttctag ataccactta acaggtttga gctagttttt ttgaaatcca aagaaaatta     1620

tagtttaaat tcaattacat agtccagtgg tccaactata attataatca aaatcaatgc     1680

aggtttgttt tttggtgcta atatgacata tgacaataag ccacgaggtg cagtaagtac     1740

ccgactaaag tttccgtggg ttctgtcatg taacacgaca tgctccaccg tcagggggga     1800

gtatgagcag agtgcctgag tttagggtca aggacaaaaa acctcaggcc tggaggaagt     1860

tttggaaaga gttcaagtgt ctgtatatcc tatggtcttc tccatcctca caccttctgc     1920

ctttgtcctg ctccctttta agccaggtta cattctaaaa attcttaact tttaacataa     1980

tattttatac caaagccaat aaatgaactg catatgatag gtatgaagta cagtgagaaa     2040

attaacacct gtgagctcat tgtcctacca cagcactaga gtgggggccg ccaaactccc     2100

atggccaaac ctggtgcacc atttgccttt gtttgtctgt tggtttgctt gagacagtct     2160

tgctctgttg cccaggctgg aatggagtgg ctattcacag gcacaatcat agcacacttt     2220

agccttaaac tcctgggctc aagtgatcca cccgcctcag tctcccaagt agctgggatt     2280

acaggtgcaa acctggcatg cctgccattg tttggcttat gatctaagga tagcttttta     2340

aattttattc attttatttt tttttgagac agtgtctcac tctgtctccc aggctggagt     2400

acagtggtac aatcttggat caccgcctcc cagtttcaag tgatctccct gcctcagcct     2460

cctaagtagc tgggactaca ggtatgtgcc accacgcctg gctaattttt atatttttag     2520

tagagacggg gtttcaccat gttgtccagg ctggtctcaa actcctgacc tcaggtgatc     2580

tgcccacctc tgcctcccaa agtgctggga ttacaggcat gagccaccat gcctggccat     2640

ttcttacact tttgtatgac atgcctattg caagcttgcg tgcctctgtc ccatgttatt     2700

ttactctggg atttaggtgg agggagcagc ttctatttgg aacattggcc atcgcatggc     2760

aaatgggtat ctgtcacttc tgctcctatt tagttggttc tactataacc tttagagcaa     2820

atcctgcagc caagccaggc atcaataggg cagaaaagta tattctgtaa ataggggtga     2880

ggagaagata tttctgaaca atagtctact gcagtaccaa attgcttttc aaagtggctg     2940

ttctaatgta ctcccgtcag tcatataagt gtcatgtaag tatcccattg atccacatcc     3000

ttgctaccct ctggtactat caggtgccct taattttgcc aagccagtgg gtatagaatg     3060

agatctcact gtggtcttag tttgcatttg cttggttact gatgagcacc ttgtcaaata     3120

tttatatacc atttgtgttt atttttttaa ataaaatgct tgctcatgct tttttgccca     3180

tttgcaaaaa aacttggggc cgggtgcagt ggctcatgcc tgtagtccca gctctttggg     3240

aggccaaggt gggcagatcg cttgagccca ggagttcgag accagccttg gcaacatggc     3300

gaaaccctgt ctttacaaaa aatacaaaaa ttagccgggt gtggtggtgt gcacctgaag     3360

tcccagctac tcagtaggtt cgctttgagc ctgggaggca gaggttgcag tgagctggga     3420

ccgcatcact acacttcagc ctgggcaaca gagaaaaacc ttttctcaga aacaaacaaa     3480

cccaaatgtg gttgtttgtc ctgattccta aaaggtcttt atgtattcta gataataatc     3540

tttggtcagt tatatgtgtt aaaaaatatc ttctttgtgg ccaggcacgg tagctcacac     3600

ctgtaatccc agcactttgc ggggctgagg tgggtggatc atctgaggtc aagagttcaa     3660

gatcagcctg gccaacacag tgaaacccca tctctactaa acatgtacaa aacttagctg     3720

ggtatggtgg cgggtgcctg taaccccagc tgctccagag gctgtggcag aagaatcgct     3780

tgaacccagg aggcagaggt tgcagcgagc caagattgtg ccattgcact ccagactggg     3840

tgacaagagt gaaattctgc ctatctatct atctatctat ctatatctat atatatatat     3900

atatatatcc tttgtaattt atttttccct ttttaaaatt ttttataaaa ttctttttta     3960

tttttatttt tagcagaggt gaggtttctg aggtttcatt atgttgccca ggctggtctt     4020

gaactcctga gctcaagtga tcctcccacc tcagccttcc aaagtgctgg aattgcagac     4080

atgagccacc gcgcccctcc tgtttttctc taattaatgg tgtctttctt tgtctttctg     4140

gtaataagca aaaagttctt catttgattt ggttaaattt ataactgttt tctcatatgg     4200

ttaacatttt ttcttgcctg gctaaagaaa tccttttctg cccaatacta taaagaggtt     4260

tgcccacatt ttattccaaa agttttaagt tttgtctttc atcttgaagt ctaatgtatc     4320

aggaactggc ttttgtgcct gttgggaggt agtgatccaa ttccatgtct tgcatgtagg     4380

taaccactgg tccctgcgcc atgtattcaa tacgtcgtct ttctcctgcg ggtctgcaat     4440

ctcacctacc atccatcaag tttccatagg gccatgggtc tgcttctggg ctccctgttc     4500

tgttccattg tcaatttgtc tatcctgtgc cagtatcaca ctgtgtttat tacaatagct     4560

ttgtaacagc tctcgatatc cggtaggaca tctccctcca ccttcttttt ctacttcaga     4620

agtgtcttag ctaggtcagg cacggtggct cacgcctgta atcccagcac tttgggaggc     4680

cgacgcggat ggatcacctg aggtcaggag ttttgagaca gcctggccaa catggtgaaa     4740

ccccatctct actaaaaaat acaaaaatta gtcaggcatg gtggcatgtg cctgtaatcc     4800

cagctatttg ggaggctgag gccggagaat tgcttgaacc cggggggcgg aggttgcagt     4860

gagccgagat cgtaccattg cactccagcc tgggtgacag agcgaaactc tgtctcagga     4920

aaaaaaagaa aagagatgtc ttggttattc ttggttcttt attattcaat ataaatttta     4980

gaagctgaat ttgaaaagat ttggattgga atttcattaa atctacaggt caatttaggg     5040

agagttgata attttacaga attgagtcat ctggtgttcc aataagaata agagaacaat     5100

tattggctgt acaattcttg ccaaatagta ggcaaagcaa agcttaggaa gtatactggt     5160

gccatttcag gaacaaagct aggtgcgaat atttttgtct ttctgaatca tgatgctgta     5220

agttctaaag tgatttctcc tcttggcttt ggacacatgg tgtttaatta cctactgctg     5280

actatccaca aacagaaaga gactggtcat gccccacagg gttggggtat ccaagataat     5340

ggagcgaggc tctcatgtgt cctaggttac acaccgaaaa tccacagttt attctgtgaa     5400

gaaaggaggc tatgtttatg atacagactg tgatattttt atcatagcct attctggtat     5460

catgtgcaaa agctataaat gaaaaacaca ggaacttggc atgtgagtca ttgctccccc     5520

taaatgacaa ttaataagga aggaacattg agacagaata aaatgatccc cttctgggtt     5580

taatttagaa agttccataa ttaggtttaa tagaaataaa tgtaaatttc tatgattaaa     5640

aataaattag cacatttagg gatacacaaa ttataaatca ttttctaaat gctaaaaaca     5700

agctcaggtt tttttcagaa gaaagtttta attttttttc tttagtggaa gatatcactc     5760

tgacggaaag ttttgatgtg aggggcggat gactataaag tgggcatctt cccccacagg     5820

aagatgtttc catctgtggg tgagaggtgc ccaccgcagc tagggcaggt tacatgtgcc     5880

ctgtgtgtgg taggacttgg agagtgatct ttatcaacgt ttttatttaa aagactatct     5940

aataaaacac aaaactatga tgttcacagg aaaaaaagaa taagaaaaaa agaaaaaaaa     6000

a                                                                     6001


<210>  29
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  29
aaaaagcggc gcgctgtgtc ttcccgcagt ctctcgtcat ggaatacgcc tctgacgctt       60

cactggaccc cgaagccccg tggcctcccg cgccccgcgc tcgcgcctgc cgcgtactgc      120

cttgggccct ggtcgcgggg ctgctgctgc tgctgctgct cgctgccgcc tgcgccgtct      180

tcctcgcctg cccctgggcc gtgtccgggg ctcgcgcctc gcccggctcc gcggccagcc      240

cgagactccg cgagggtccc gagctttcgc ccgacgatcc cgccggcctc ttggacctgc      300

ggcagggcat gtttgcgcag ctggtggccc aaaatgttct gctgatcgat gggcccctga      360

gctggtacag tgacccaggc ctggcaggcg tgtccctgac ggggggcctg agctacaaag      420

aggacacgaa ggagctggtg gtggccaagg ctggagtcta ctatgtcttc tttcaactag      480

agctgcggcg cgtggtggcc ggcgagggct caggctccgt ttcacttgcg ctgcacctgc      540

agccactgcg ctctgctgct ggggccgccg ccctggcttt gaccgtggac ctgccacccg      600

cctcctccga ggctcggaac tcggccttcg gtttccaggg ccgcttgctg cacctgagtg      660

ccggccagcg cctgggcgtc catcttcaca ctgaggccag ggcacgccat gcctggcagc      720

ttacccaggg cgccacagtc ttgggactct tccgggtgac ccccgaaatc ccagccggac      780

tcccttcacc gaggtcggaa taacgtccag cctgggtgca gcccacctgg acagagtccg      840

aatcctactc catccttcat ggagacccct ggtgctgggt ccctgctgct ttctctacct      900

caaggggctt ggcaggggtc cctgctgctg acctcccctt gaggaccctc ctcacccact      960

ccttccccaa gttggacctt gatatttatt ctgagcctga gctcagataa tatattatat     1020

atattatata tatatatata tttctattta aagaggatcc tgagtttgtg aatggacttt     1080

tttagaggag ttgttttggg gggggggggg tcttcgacat tgccgaggct ggtcttgaac     1140

tcctggactt agacgatcct cctgcctcag cctcccaagc aactgggatt catcctttct     1200

attaattcat tgtacttatt tgcttatttg tgtgtattga gcatctgtaa tgtgccagca     1260

ttgtgcccag gctagggggc tatagaaaca tctagaaata gactgaaaga aaatctgagt     1320

tatggtaata cgtgaggaat ttaaagactc atccccagcc tccacctcct gtgtgatact     1380

tgggggctag cttttttctt tctttctttt ttttgagatg gtcttgttct gtcaaccagg     1440

ctagaatgca gcggtgcaat catgagtcaa tgcagcctcc agcctcgacc tcccgaggct     1500

caggtgatcc tcccatctca gcctctcgag tagctgggac cacagttgtg tgccaccaca     1560

cttggctaac tttttaattt ttttgcggag acggtattgc tatgttgcca aggttgttta     1620

catgccagta caatttataa taaacactca tttttcctcc ctctgaaaaa aaaaaaaaaa     1680


<210>  30
<211>  1835
<212>  DNA
<213>  Homo sapiens

<400>  30
tccccattga ataacagcca agttgctttg gtttctattt ctttgttaag tcgttccctc       60

tacaaaggac ttcctagtgg gtgtgaaagg cagcggtggc cacagaggcg gcggagagat      120

ggccttcagc ggttcccagg ctccctacct gagtccagct gtcccctttt ctgggactat      180

tcaaggaggt ctccaggacg gacttcagat cactgtcaat gggaccgttc tcagctccag      240

tggaaccagg tttgctgtga actttcagac tggcttcagt ggaaatgaca ttgccttcca      300

cttcaaccct cggtttgaag atggagggta cgtggtgtgc aacacgaggc agaacggaag      360

ctgggggccc gaggagagga agacacacat gcctttccag aaggggatgc cctttgacct      420

ctgcttcctg gtgcagagct cagatttcaa ggtgatggtg aacgggatcc tcttcgtgca      480

gtacttccac cgcgtgccct tccaccgtgt ggacaccatc tccgtcaatg gctctgtgca      540

gctgtcctac atcagcttcc agaacccccg cacagtccct gttcagcctg ccttctccac      600

ggtgccgttc tcccagcctg tctgtttccc acccaggccc agggggcgca gacaaaaacc      660

tcccggcgtg tggcctgcca acccggctcc cattacccag acagtcatcc acacagtgca      720

gagcgcccct ggacagatgt tctctactcc cgccatccca cctatgatgt acccccaccc      780

cgcctatccg atgcctttca tcaccaccat tctgggaggg ctgtacccat ccaagtccat      840

cctcctgtca ggcactgtcc tgcccagtgc tcagaggttc cacatcaacc tgtgctctgg      900

gaaccacatc gccttccacc tgaacccccg ttttgatgag aatgctgtgg tccgcaacac      960

ccagatcgac aactcctggg ggtctgagga gcgaagtctg ccccgaaaaa tgcccttcgt     1020

ccgtggccag agcttctcag tgtggatctt gtgtgaagct cactgcctca aggtggccgt     1080

ggatggtcag cacctgtttg aatactacca tcgcctgagg aacctgccca ccatcaacag     1140

actggaagtg gggggcgaca tccagctgac ccatgtgcag acataggcgg cttcctggcc     1200

ctggggccgg gggctggggt gtggggcagt ctgggtcctc tcatcatccc cacttcccag     1260

gcccagcctt tccaaccctg cctgggatct gggctttaat gcagaggcca tgtccttgtc     1320

tggtcctgct tctggctaca gccaccctgg aacggagaag gcagctgacg gggattgcct     1380

tcctcagccg cagcagcacc tggggctcca gctgctggaa tcctaccatc ccaggaggca     1440

ggcacagcca gggagagggg aggagtgggc agtgaagatg aagccccatg ctcagtcccc     1500

tcccatcccc cacgcagctc caccccagtc ccaagccacc agctgtctgc tcctggtggg     1560

aggtggcctc ctcagcccct cctctctgac ctttaacctc actctcacct tgcaccgtgc     1620

accaaccctt cacccctcct ggaaagcagg cctgatggct tcccactggc ctccaccacc     1680

tgaccagagt gttctcttca gaggactggc tcctttccca gtgtccttaa aataaagaaa     1740

tgaaaatgct tgttggcaca ttcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                1835


<210>  31
<211>  2448
<212>  DNA
<213>  Homo sapiens

<400>  31
agaacactta caggatgtgt gtagtgtggc atgacagaga actttggttt cctttaatgt       60

gactgtagac ctggcagtgt tactataaga atcactggca atcagacacc cgggtgtgct      120

gagctagcac tcagtggggg cggctactgc tcatgtgatt gtggagtaga cagttggaag      180

aagtacccag tccatttgga gagttaaaac tgtgcctaac agaggtgtcc tctgactttt      240

cttctgcaag ctccatgttt tcacatcttc cctttgactg tgtcctgctg ctgctgctgc      300

tactacttac aaggtcctca gaagtggaat acagagcgga ggtcggtcag aatgcctatc      360

tgccctgctt ctacacccca gccgccccag ggaacctcgt gcccgtctgc tggggcaaag      420

gagcctgtcc tgtgtttgaa tgtggcaacg tggtgctcag gactgatgaa agggatgtga      480

attattggac atccagatac tggctaaatg gggatttccg caaaggagat gtgtccctga      540

ccatagagaa tgtgactcta gcagacagtg ggatctactg ctgccggatc caaatcccag      600

gcataatgaa tgatgaaaaa tttaacctga agttggtcat caaaccagcc aaggtcaccc      660

ctgcaccgac tcggcagaga gacttcactg cagcctttcc aaggatgctt accaccaggg      720

gacatggccc agcagagaca cagacactgg ggagcctccc tgatataaat ctaacacaaa      780

tatccacatt ggccaatgag ttacgggact ctagattggc caatgactta cgggactctg      840

gagcaaccat cagaataggc atctacatcg gagcagggat ctgtgctggg ctggctctgg      900

ctcttatctt cggcgcttta attttcaaat ggtattctca tagcaaagag aagatacaga      960

atttaagcct catctctttg gccaacctcc ctccctcagg attggcaaat gcagtagcag     1020

agggaattcg ctcagaagaa aacatctata ccattgaaga gaacgtatat gaagtggagg     1080

agcccaatga gtattattgc tatgtcagca gcaggcagca accctcacaa cctttgggtt     1140

gtcgctttgc aatgccatag atccaaccac cttatttttg agcttggtgt tttgtctttt     1200

tcagaaacta tgagctgtgt cacctgactg gttttggagg ttctgtccac tgctatggag     1260

cagagttttc ccattttcag aagataatga ctcacatggg aattgaactg ggacctgcac     1320

tgaacttaaa caggcatgtc attgcctctg tatttaagcc aacagagtta cccaacccag     1380

agactgttaa tcatggatgt tagagctcaa acgggctttt atatacacta ggaattcttg     1440

acgtggggtc tctggagctc caggaaattc gggcacatca tatgtccatg aaacttcaga     1500

taaactaggg aaaactgggt gctgaggtga aagcataact tttttggcac agaaagtcta     1560

aaggggccac tgattttcaa agagatctgt gatccctttt tgttttttgt ttttgagatg     1620

gagtcttgct ctgttgccca ggctggagtg caatggcaca atctcggctc actgcaagct     1680

ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc tgagtggctg ggattacagg     1740

catgcaccac catgcccagc taatttgttg tatttttagt agagacaggg tttcaccatg     1800

ttggccagtg tggtctcaaa ctcctgacct catgatttgc ctgcctcggc ctcccaaagc     1860

actgggatta caggcgtgag ccaccacatc cagccagtga tccttaaaag attaagagat     1920

gactggacca ggtctacctt gatcttgaag attcccttgg aatgttgaga tttaggctta     1980

tttgagcact gcctgcccaa ctgtcagtgc cagtgcatag cccttctttt gtctccctta     2040

tgaagactgc cctgcagggc tgagatgtgg caggagctcc cagggaaaaa cgaagtgcat     2100

ttgattggtg tgtattggcc aagttttgct tgttgtgtgc ttgaaagaaa atatctctga     2160

ccaacttctg tattcgtgga ccaaactgaa gctatatttt tcacagaaga agaagcagtg     2220

acggggacac aaattctgtt gcctggtgga aagaaggcaa aggccttcag caatctatat     2280

taccagcgct ggatcctttg acagagagtg gtccctaaac ttaaatttca agacggtata     2340

ggcttgatct gtcttgctta ttgttgcccc ctgcgcctag cacaattctg acacacaatt     2400

ggaacttact aaaaattttt ttttactgtt aaaaaaaaaa aaaaaaaa                  2448


<210>  32
<211>  5748
<212>  DNA
<213>  Homo sapiens

<400>  32
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc actttgatga gcactagtgc tacagcaact gagacagcaa     1140

ccaagaggca agaaacctgg gattggtttt catggttgtt tctaccatca gagtcaaaga     1200

atcatcttca cacaacaaca caaatggctg gtacgtcttc aaataccatc tcagcaggct     1260

gggagccaaa tgaagaaaat gaagatgaaa gagacagaca cctcagtttt tctggatcag     1320

gcattgatga tgatgaagat tttatctcca gcaccatttc aaccacacca cgggcttttg     1380

accacacaaa acagaaccag gactggaccc agtggaaccc aagccattca aatccggaag     1440

tgctacttca gacaaccaca aggatgactg atgtagacag aaatggcacc actgcttatg     1500

aaggaaactg gaacccagaa gcacaccctc ccctcattca ccatgagcat catgaggaag     1560

aagagacccc acattctaca agcacaatcc aggcaactcc tagtagtaca acggaagaaa     1620

cagctaccca gaaggaacag tggtttggca acagatggca tgagggatat cgccaaacac     1680

ccaaagaaga ctcccattcg acaacaggga cagctgcagc ctcagctcat accagccatc     1740

caatgcaagg aaggacaaca ccaagcccag aggacagttc ctggactgat ttcttcaacc     1800

caatctcaca ccccatggga cgaggtcatc aagcaggaag aaggatggat atggactcca     1860

gtcatagtat aacgcttcag cctactgcaa atccaaacac aggtttggtg gaagatttgg     1920

acaggacagg acctctttca atgacaacgc agcagagtaa ttctcagagc ttctctacat     1980

cacatgaagg cttggaagaa gataaagacc atccaacaac ttctactctg acatcaagca     2040

ataggaatga tgtcacaggt ggaagaagag acccaaatca ttctgaaggc tcaactactt     2100

tactggaagg ttatacctct cattacccac acacgaagga aagcaggacc ttcatcccag     2160

tgacctcagc taagactggg tcctttggag ttactgcagt tactgttgga gattccaact     2220

ctaatgtcaa tcgttcctta tcaggagacc aagacacatt ccaccccagt ggggggtccc     2280

ataccactca tggatctgaa tcagatggac actcacatgg gagtcaagaa ggtggagcaa     2340

acacaacctc tggtcctata aggacacccc aaattccaga atggctgatc atcttggcat     2400

ccctcttggc cttggctttg attcttgcag tttgcattgc agtcaacagt cgaagaaggt     2460

gtgggcagaa gaaaaagcta gtgatcaaca gtggcaatgg agctgtggag gacagaaagc     2520

caagtggact caacggagag gccagcaagt ctcaggaaat ggtgcatttg gtgaacaagg     2580

agtcgtcaga aactccagac cagtttatga cagctgatga gacaaggaac ctgcagaatg     2640

tggacatgaa gattggggtg taacacctac accattatct tggaaagaaa caaccgttgg     2700

aaacataacc attacaggga gctgggacac ttaacagatg caatgtgcta ctgattgttt     2760

cattgcgaat cttttttagc ataaaatttt ctactctttt tgttttttgt gttttgttct     2820

ttaaagtcag gtccaatttg taaaaacagc attgctttct gaaattaggg cccaattaat     2880

aatcagcaag aatttgatcg ttccagttcc cacttggagg cctttcatcc ctcgggtgtg     2940

ctatggatgg cttctaacaa aaactacaca tatgtattcc tgatcgccaa cctttccccc     3000

accagctaag gacatttccc agggttaata gggcctggtc cctgggagga aatttgaatg     3060

ggtccatttt gcccttccat agcctaatcc ctgggcattg ctttccactg aggttggggg     3120

ttggggtgta ctagttacac atcttcaaca gaccccctct agaaattttt cagatgcttc     3180

tgggagacac ccaaagggtg aagctattta tctgtagtaa actatttatc tgtgtttttg     3240

aaatattaaa ccctggatca gtcctttgat cagtataatt ttttaaagtt actttgtcag     3300

aggcacaaaa gggtttaaac tgattcataa taaatatctg tacttcttcg atcttcacct     3360

tttgtgctgt gattcttcag tttctaaacc agcactgtct gggtccctac aatgtatcag     3420

gaagagctga gaatggtaag gagactcttc taagtcttca tctcagagac cctgagttcc     3480

cactcagacc cactcagcca aatctcatgg aagaccaagg agggcagcac tgtttttgtt     3540

ttttgttttt tgtttttttt ttttgacact gtccaaaggt tttccatcct gtcctggaat     3600

cagagttgga agctgaggag cttcagcctc ttttatggtt taatggccac ctgttctctc     3660

ctgtgaaagg ctttgcaaag tcacattaag tttgcatgac ctgttatccc tggggcccta     3720

tttcatagag gctggcccta ttagtgattt ccaaaaacaa tatggaagtg ccttttgatg     3780

tcttacaata agagaagaag ccaatggaaa tgaaagagat tggcaaaggg gaaggatgat     3840

gccatgtaga tcctgtttga catttttatg gctgtatttg taaacttaaa cacaccagtg     3900

tctgttcttg atgcagttgc tatttaggat gagttaagtg cctggggagt ccctcaaaag     3960

gttaaaggga ttcccatcat tggaatctta tcaccagata ggcaagttta tgaccaaaca     4020

agagagtact ggctttatcc tctaacctca tattttctcc cacttggcaa gtcctttgtg     4080

gcatttattc atcagtcagg gtgtccgatt ggtcctagaa cttccaaagg ctgcttgtca     4140

tagaagccat tgcatctata aagcaacggc tcctgttaaa tggtatctcc tttctgaggc     4200

tcctactaaa agtcatttgt tacctaaact tatgtgctta acaggcaatg cttctcagac     4260

cacaaagcag aaagaagaag aaaagctcct gactaaatca gggctgggct tagacagagt     4320

tgatctgtag aatatcttta aaggagagat gtcaactttc tgcactattc ccagcctctg     4380

ctcctccctg tctaccctct cccctccctc tctccctcca cttcacccca caatcttgaa     4440

aaacttcctt tctcttctgt gaacatcatt ggccagatcc attttcagtg gtctggattt     4500

ctttttattt tcttttcaac ttgaaagaaa ctggacatta ggccactatg tgttgttact     4560

gccactagtg ttcaagtgcc tcttgttttc ccagagattt cctgggtctg ccagaggccc     4620

agacaggctc actcaagctc tttaactgaa aagcaacaag ccactccagg acaaggttca     4680

aaatggttac aacagcctct acctgtcgcc ccagggagaa aggggtagtg atacaagtct     4740

catagccaga gatggttttc cactccttct agatattccc aaaaagaggc tgagacagga     4800

ggttattttc aattttattt tggaattaaa tacttttttc cctttattac tgttgtagtc     4860

cctcacttgg atatacctct gttttcacga tagaaataag ggaggtctag agcttctatt     4920

ccttggccat tgtcaacgga gagctggcca agtcttcaca aacccttgca acattgcctg     4980

aagtttatgg aataagatgt attctcactc ccttgatctc aagggcgtaa ctctggaagc     5040

acagcttgac tacacgtcat ttttaccaat gattttcagg tgacctgggc taagtcattt     5100

aaactgggtc tttataaaag taaaaggcca acatttaatt attttgcaaa gcaacctaag     5160

agctaaagat gtaatttttc ttgcaattgt aaatcttttg tgtctcctga agacttccct     5220

taaaattagc tctgagtgaa aaatcaaaag agacaaaaga catcttcgaa tccatatttc     5280

aagcctggta gaattggctt ttctagcaga acctttccaa aagttttata ttgagattca     5340

taacaacacc aagaattgat tttgtagcca acattcattc aatactgtta tatcagagga     5400

gtaggagaga ggaaacattt gacttatctg gaaaagcaaa atgtacttaa gaataagaat     5460

aacatggtcc attcaccttt atgttataga tatgtctttg tgtaaatcat ttgttttgag     5520

ttttcaaaga atagcccatt gttcattctt gtgctgtaca atgaccactg ttattgttac     5580

tttgactttt cagagcacac ccttcctctg gtttttgtat atttattgat ggatcaataa     5640

taatgaggaa agcatgatat gtatattgct gagttgaaag cacttattgg aaaatattaa     5700

aaggctaaca ttaaaagact aaaggaaaca gaaaaaaaaa aaaaaaaa                  5748


<210>  33
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Antisense polynucleotide

<400>  33
caaaccaggg uauucu                                                       16


<210>  34
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Antisense polynucleotide

<400>  34
gggagagagg aagagggaug ggcgaccgaa cgugcccuuc aaagccguuc acuaaccagu       60

ggcauaaccc agaggucgau aguacuggau cccccc                                 96


