                               SEQUENCE LISTING

<110> GENENTECH, INC. ET AL.
 
<120> PCSK9-BINDING POLYPEPTIDES AND METHODS OF USE

<130> P4562R1-WO

<140>
<141>

<150> 61/499,034
<151> 2011-06-20

<160> 31    

<170> PatentIn version 3.5

<210> 1
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Asp or Thr

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Leu or Asn

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Ala, Asp, Glu, His, Lys, Leu, Arg, Ser, Val or Tyr

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Leu or Asn

<220>
<221> MOD_RES
<222> (14)..(14)
<223> His, Trp or Tyr

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ile, Leu, Thr or Val

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Lys, Asn, Arg or Gln

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Asp, Lys, Asn, Gln or Arg

<400> 1
Gly Xaa Xaa Glu Cys Leu Xaa Asn Xaa Gly Gly Cys Ser Xaa Xaa Cys 
1               5                   10                  15      


Xaa Xaa Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln 
            20                  25                  30          


Leu Val Ala Gln Arg Arg Cys Glu 
        35                  40  


<210> 2
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser Trp Val Cys 
1               5                   10                  15      


Lys Asp Leu Lys 
            20  


<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys 
1               5                   10                  15      


Arg Asp Leu Lys 
            20  


<210> 4
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser Tyr Val Cys 
1               5                   10                  15      


Lys Asp Leu Lys 
            20  


<210> 5
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Thr Asn Glu Cys Leu Ser Asn Leu Gly Gly Cys Ser His Ile Cys 
1               5                   10                  15      


Arg Lys Leu Lys 
            20  


<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser Tyr Val Cys 
1               5                   10                  15      


Arg Asp Leu Lys 
            20  


<210> 7
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gly Thr Asn Glu Cys Leu Glu Asn Leu Gly Gly Cys Ser His Val Cys 
1               5                   10                  15      


Arg Asp Leu Lys 
            20  


<210> 8
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly Thr Asn Glu Cys Leu Arg Asn Leu Gly Gly Cys Ser His Ile Cys 
1               5                   10                  15      


Arg Asn Leu Lys 
            20  


<210> 9
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys 
1               5                   10                  15      


Lys Asp Leu Lys 
            20  


<210> 10
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Thr Asn Glu Cys Leu Val Asn Leu Gly Gly Cys Ser His Ile Cys 
1               5                   10                  15      


Arg Asp Leu Lys 
            20  


<210> 11
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser Tyr Val Cys 
1               5                   10                  15      


Lys Asp Leu Lys 
            20  


<210> 12
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gly Thr Asn Glu Cys Leu Asp Asn Leu Gly Gly Cys Ser His Val Cys 
1               5                   10                  15      


Arg Lys Leu Lys 
            20  


<210> 13
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Thr Asn Glu Cys Leu Leu Asn Leu Gly Gly Cys Ser His Thr Cys 
1               5                   10                  15      


Arg Lys Leu Lys 
            20  


<210> 14
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Gly Thr Asn Glu Cys Leu His Asn Leu Gly Gly Cys Ser His Ile Cys 
1               5                   10                  15      


Arg Asp Leu Lys 
            20  


<210> 15
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys 
1               5                   10                  15      


Lys Asp Leu Lys 
            20  


<210> 16
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser Tyr Val Cys 
1               5                   10                  15      


Arg Asp Leu Lys 
            20  


<210> 17
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gly Thr Asn Glu Cys Leu Ala Asn Leu Gly Gly Cys Ser His Ile Cys 
1               5                   10                  15      


Arg Lys Leu Lys 
            20  


<210> 18
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gly Thr Leu Glu Cys Leu Asp Asn Leu Gly Gly Cys Ser His Ile Cys 
1               5                   10                  15      


Lys Gln Leu Lys 
            20  


<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser Tyr Val Cys 
1               5                   10                  15      


Arg Asp Leu Lys 
            20  


<210> 20
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Thr Asn Glu Cys Leu Ala Asn Leu Gly Gly Cys Ser His Val Cys 
1               5                   10                  15      


Arg Lys Leu Lys 
            20  


<210> 21
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Thr Asn Glu Cys Leu Ala Asn Leu Gly Gly Cys Ser His Ile Cys 
1               5                   10                  15      


Gln Lys Leu Lys 
            20  


<210> 22
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Gly Thr Asn Glu Cys Leu Lys Asn Leu Gly Gly Cys Ser His Ile Cys 
1               5                   10                  15      


Arg Ala Leu Lys 
            20  


<210> 23
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gly Asp Asn Glu Cys Leu Asp Asn Leu Gly Gly Cys Ser His Leu Cys 
1               5                   10                  15      


Arg Lys Leu Lys 
            20  


<210> 24
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gly Thr Asn Glu Cys Leu Lys Asn Leu Gly Gly Cys Ser His Val Cys 
1               5                   10                  15      


Lys Lys Leu Lys 
            20  


<210> 25
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser Tyr Val Cys 
1               5                   10                  15      


Arg Asp Leu Lys 
            20  


<210> 26
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Gly Thr Asn Glu Cys Leu Tyr Asn Leu Gly Gly Cys Ser His Ile Cys 
1               5                   10                  15      


Lys Arg Leu Lys 
            20  


<210> 27
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gly Thr Asn Glu Cys Leu Asp Asn Leu Gly Gly Cys Ser His Leu Cys 
1               5                   10                  15      


Lys Lys Leu Lys 
            20  


<210> 28
<211> 20
<212> PRT
<213> Homo sapiens

<400> 28
Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys 
1               5                   10                  15      


Asn Asp Leu Lys 
            20  


<210> 29
<211> 20
<212> PRT
<213> Homo sapiens

<400> 29
Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln 
1               5                   10                  15      


Arg Arg Cys Glu 
            20  


<210> 30
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Gly Gly Gly Ser Gly Ala Ala Gln Val Thr Asn Lys Thr His Thr 
1               5                   10                  15  


<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      8xHis tag

<400> 31
His His His His His His His His 
1               5               


