                               SEQUENCE LISTING

<110> GENOMATICA, INC.
 
<120> MICROORGANISMS FOR PRODUCING ISOBUTANOL AND METHODS RELATED
      THERETO

<130> 12956-142

<150> 61/500,124
<151> 2011-06-22

<150> 61/502,708
<151> 2011-06-29

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 3525
<212> DNA
<213> Nocardia iowensis

<400> 1
atggcagtgg attcaccgga tgagcggcta cagcgccgca ttgcacagtt gtttgcagaa       60

gatgagcagg tcaaggccgc acgtccgctc gaagcggtga gcgcggcggt gagcgcgccc      120

ggtatgcggc tggcgcagat cgccgccact gttatggcgg gttacgccga ccgcccggcc      180

gccgggcagc gtgcgttcga actgaacacc gacgacgcga cgggccgcac ctcgctgcgg      240

ttacttcccc gattcgagac catcacctat cgcgaactgt ggcagcgagt cggcgaggtt      300

gccgcggcct ggcatcatga tcccgagaac cccttgcgcg caggtgattt cgtcgccctg      360

ctcggcttca ccagcatcga ctacgccacc ctcgacctgg ccgatatcca cctcggcgcg      420

gttaccgtgc cgttgcaggc cagcgcggcg gtgtcccagc tgatcgctat cctcaccgag      480

acttcgccgc ggctgctcgc ctcgaccccg gagcacctcg atgcggcggt cgagtgccta      540

ctcgcgggca ccacaccgga acgactggtg gtcttcgact accaccccga ggacgacgac      600

cagcgtgcgg ccttcgaatc cgcccgccgc cgccttgccg acgcgggcag cttggtgatc      660

gtcgaaacgc tcgatgccgt gcgtgcccgg ggccgcgact taccggccgc gccactgttc      720

gttcccgaca ccgacgacga cccgctggcc ctgctgatct acacctccgg cagcaccgga      780

acgccgaagg gcgcgatgta caccaatcgg ttggccgcca cgatgtggca ggggaactcg      840

atgctgcagg ggaactcgca acgggtcggg atcaatctca actacatgcc gatgagccac      900

atcgccggtc gcatatcgct gttcggcgtg ctcgctcgcg gtggcaccgc atacttcgcg      960

gccaagagcg acatgtcgac actgttcgaa gacatcggct tggtacgtcc caccgagatc     1020

ttcttcgtcc cgcgcgtgtg cgacatggtc ttccagcgct atcagagcga gctggaccgg     1080

cgctcggtgg cgggcgccga cctggacacg ctcgatcggg aagtgaaagc cgacctccgg     1140

cagaactacc tcggtgggcg cttcctggtg gcggtcgtcg gcagcgcgcc gctggccgcg     1200

gagatgaaga cgttcatgga gtccgtcctc gatctgccac tgcacgacgg gtacgggtcg     1260

accgaggcgg gcgcaagcgt gctgctcgac aaccagatcc agcggccgcc ggtgctcgat     1320

tacaagctcg tcgacgtgcc cgaactgggt tacttccgca ccgaccggcc gcatccgcgc     1380

ggtgagctgt tgttgaaggc ggagaccacg attccgggct actacaagcg gcccgaggtc     1440

accgcggaga tcttcgacga ggacggcttc tacaagaccg gcgatatcgt ggccgagctc     1500

gagcacgatc ggctggtcta tgtcgaccgt cgcaacaatg tgctcaaact gtcgcagggc     1560

gagttcgtga ccgtcgccca tctcgaggcc gtgttcgcca gcagcccgct gatccggcag     1620

atcttcatct acggcagcag cgaacgttcc tatctgctcg cggtgatcgt ccccaccgac     1680

gacgcgctgc gcggccgcga caccgccacc ttgaaatcgg cactggccga atcgattcag     1740

cgcatcgcca aggacgcgaa cctgcagccc tacgagattc cgcgcgattt cctgatcgag     1800

accgagccgt tcaccatcgc caacggactg ctctccggca tcgcgaagct gctgcgcccc     1860

aatctgaagg aacgctacgg cgctcagctg gagcagatgt acaccgatct cgcgacaggc     1920

caggccgatg agctgctcgc cctgcgccgc gaagccgccg acctgccggt gctcgaaacc     1980

gtcagccggg cagcgaaagc gatgctcggc gtcgcctccg ccgatatgcg tcccgacgcg     2040

cacttcaccg acctgggcgg cgattccctt tccgcgctgt cgttctcgaa cctgctgcac     2100

gagatcttcg gggtcgaggt gccggtgggt gtcgtcgtca gcccggcgaa cgagctgcgc     2160

gatctggcga attacattga ggcggaacgc aactcgggcg cgaagcgtcc caccttcacc     2220

tcggtgcacg gcggcggttc cgagatccgc gccgccgatc tgaccctcga caagttcatc     2280

gatgcccgca ccctggccgc cgccgacagc attccgcacg cgccggtgcc agcgcagacg     2340

gtgctgctga ccggcgcgaa cggctacctc ggccggttcc tgtgcctgga atggctggag     2400

cggctggaca agacgggtgg cacgctgatc tgcgtcgtgc gcggtagtga cgcggccgcg     2460

gcccgtaaac ggctggactc ggcgttcgac agcggcgatc ccggcctgct cgagcactac     2520

cagcaactgg ccgcacggac cctggaagtc ctcgccggtg atatcggcga cccgaatctc     2580

ggtctggacg acgcgacttg gcagcggttg gccgaaaccg tcgacctgat cgtccatccc     2640

gccgcgttgg tcaaccacgt ccttccctac acccagctgt tcggccccaa tgtcgtcggc     2700

accgccgaaa tcgtccggtt ggcgatcacg gcgcggcgca agccggtcac ctacctgtcg     2760

accgtcggag tggccgacca ggtcgacccg gcggagtatc aggaggacag cgacgtccgc     2820

gagatgagcg cggtgcgcgt cgtgcgcgag agttacgcca acggctacgg caacagcaag     2880

tgggcggggg aggtcctgct gcgcgaagca cacgatctgt gtggcttgcc ggtcgcggtg     2940

ttccgttcgg acatgatcct ggcgcacagc cggtacgcgg gtcagctcaa cgtccaggac     3000

gtgttcaccc ggctgatcct cagcctggtc gccaccggca tcgcgccgta ctcgttctac     3060

cgaaccgacg cggacggcaa ccggcagcgg gcccactatg acggcttgcc ggcggacttc     3120

acggcggcgg cgatcaccgc gctcggcatc caagccaccg aaggcttccg gacctacgac     3180

gtgctcaatc cgtacgacga tggcatctcc ctcgatgaat tcgtcgactg gctcgtcgaa     3240

tccggccacc cgatccagcg catcaccgac tacagcgact ggttccaccg tttcgagacg     3300

gcgatccgcg cgctgccgga aaagcaacgc caggcctcgg tgctgccgtt gctggacgcc     3360

taccgcaacc cctgcccggc ggtccgcggc gcgatactcc cggccaagga gttccaagcg     3420

gcggtgcaaa cagccaaaat cggtccggaa caggacatcc cgcatttgtc cgcgccactg     3480

atcgataagt acgtcagcga tctggaactg cttcagctgc tctaa                     3525


<210> 2
<211> 1174
<212> PRT
<213> Nocardia iowensis

<400> 2
Met Ala Val Asp Ser Pro Asp Glu Arg Leu Gln Arg Arg Ile Ala Gln 
1               5                   10                  15      


Leu Phe Ala Glu Asp Glu Gln Val Lys Ala Ala Arg Pro Leu Glu Ala 
            20                  25                  30          


Val Ser Ala Ala Val Ser Ala Pro Gly Met Arg Leu Ala Gln Ile Ala 
        35                  40                  45              


Ala Thr Val Met Ala Gly Tyr Ala Asp Arg Pro Ala Ala Gly Gln Arg 
    50                  55                  60                  


Ala Phe Glu Leu Asn Thr Asp Asp Ala Thr Gly Arg Thr Ser Leu Arg 
65                  70                  75                  80  


Leu Leu Pro Arg Phe Glu Thr Ile Thr Tyr Arg Glu Leu Trp Gln Arg 
                85                  90                  95      


Val Gly Glu Val Ala Ala Ala Trp His His Asp Pro Glu Asn Pro Leu 
            100                 105                 110         


Arg Ala Gly Asp Phe Val Ala Leu Leu Gly Phe Thr Ser Ile Asp Tyr 
        115                 120                 125             


Ala Thr Leu Asp Leu Ala Asp Ile His Leu Gly Ala Val Thr Val Pro 
    130                 135                 140                 


Leu Gln Ala Ser Ala Ala Val Ser Gln Leu Ile Ala Ile Leu Thr Glu 
145                 150                 155                 160 


Thr Ser Pro Arg Leu Leu Ala Ser Thr Pro Glu His Leu Asp Ala Ala 
                165                 170                 175     


Val Glu Cys Leu Leu Ala Gly Thr Thr Pro Glu Arg Leu Val Val Phe 
            180                 185                 190         


Asp Tyr His Pro Glu Asp Asp Asp Gln Arg Ala Ala Phe Glu Ser Ala 
        195                 200                 205             


Arg Arg Arg Leu Ala Asp Ala Gly Ser Leu Val Ile Val Glu Thr Leu 
    210                 215                 220                 


Asp Ala Val Arg Ala Arg Gly Arg Asp Leu Pro Ala Ala Pro Leu Phe 
225                 230                 235                 240 


Val Pro Asp Thr Asp Asp Asp Pro Leu Ala Leu Leu Ile Tyr Thr Ser 
                245                 250                 255     


Gly Ser Thr Gly Thr Pro Lys Gly Ala Met Tyr Thr Asn Arg Leu Ala 
            260                 265                 270         


Ala Thr Met Trp Gln Gly Asn Ser Met Leu Gln Gly Asn Ser Gln Arg 
        275                 280                 285             


Val Gly Ile Asn Leu Asn Tyr Met Pro Met Ser His Ile Ala Gly Arg 
    290                 295                 300                 


Ile Ser Leu Phe Gly Val Leu Ala Arg Gly Gly Thr Ala Tyr Phe Ala 
305                 310                 315                 320 


Ala Lys Ser Asp Met Ser Thr Leu Phe Glu Asp Ile Gly Leu Val Arg 
                325                 330                 335     


Pro Thr Glu Ile Phe Phe Val Pro Arg Val Cys Asp Met Val Phe Gln 
            340                 345                 350         


Arg Tyr Gln Ser Glu Leu Asp Arg Arg Ser Val Ala Gly Ala Asp Leu 
        355                 360                 365             


Asp Thr Leu Asp Arg Glu Val Lys Ala Asp Leu Arg Gln Asn Tyr Leu 
    370                 375                 380                 


Gly Gly Arg Phe Leu Val Ala Val Val Gly Ser Ala Pro Leu Ala Ala 
385                 390                 395                 400 


Glu Met Lys Thr Phe Met Glu Ser Val Leu Asp Leu Pro Leu His Asp 
                405                 410                 415     


Gly Tyr Gly Ser Thr Glu Ala Gly Ala Ser Val Leu Leu Asp Asn Gln 
            420                 425                 430         


Ile Gln Arg Pro Pro Val Leu Asp Tyr Lys Leu Val Asp Val Pro Glu 
        435                 440                 445             


Leu Gly Tyr Phe Arg Thr Asp Arg Pro His Pro Arg Gly Glu Leu Leu 
    450                 455                 460                 


Leu Lys Ala Glu Thr Thr Ile Pro Gly Tyr Tyr Lys Arg Pro Glu Val 
465                 470                 475                 480 


Thr Ala Glu Ile Phe Asp Glu Asp Gly Phe Tyr Lys Thr Gly Asp Ile 
                485                 490                 495     


Val Ala Glu Leu Glu His Asp Arg Leu Val Tyr Val Asp Arg Arg Asn 
            500                 505                 510         


Asn Val Leu Lys Leu Ser Gln Gly Glu Phe Val Thr Val Ala His Leu 
        515                 520                 525             


Glu Ala Val Phe Ala Ser Ser Pro Leu Ile Arg Gln Ile Phe Ile Tyr 
    530                 535                 540                 


Gly Ser Ser Glu Arg Ser Tyr Leu Leu Ala Val Ile Val Pro Thr Asp 
545                 550                 555                 560 


Asp Ala Leu Arg Gly Arg Asp Thr Ala Thr Leu Lys Ser Ala Leu Ala 
                565                 570                 575     


Glu Ser Ile Gln Arg Ile Ala Lys Asp Ala Asn Leu Gln Pro Tyr Glu 
            580                 585                 590         


Ile Pro Arg Asp Phe Leu Ile Glu Thr Glu Pro Phe Thr Ile Ala Asn 
        595                 600                 605             


Gly Leu Leu Ser Gly Ile Ala Lys Leu Leu Arg Pro Asn Leu Lys Glu 
    610                 615                 620                 


Arg Tyr Gly Ala Gln Leu Glu Gln Met Tyr Thr Asp Leu Ala Thr Gly 
625                 630                 635                 640 


Gln Ala Asp Glu Leu Leu Ala Leu Arg Arg Glu Ala Ala Asp Leu Pro 
                645                 650                 655     


Val Leu Glu Thr Val Ser Arg Ala Ala Lys Ala Met Leu Gly Val Ala 
            660                 665                 670         


Ser Ala Asp Met Arg Pro Asp Ala His Phe Thr Asp Leu Gly Gly Asp 
        675                 680                 685             


Ser Leu Ser Ala Leu Ser Phe Ser Asn Leu Leu His Glu Ile Phe Gly 
    690                 695                 700                 


Val Glu Val Pro Val Gly Val Val Val Ser Pro Ala Asn Glu Leu Arg 
705                 710                 715                 720 


Asp Leu Ala Asn Tyr Ile Glu Ala Glu Arg Asn Ser Gly Ala Lys Arg 
                725                 730                 735     


Pro Thr Phe Thr Ser Val His Gly Gly Gly Ser Glu Ile Arg Ala Ala 
            740                 745                 750         


Asp Leu Thr Leu Asp Lys Phe Ile Asp Ala Arg Thr Leu Ala Ala Ala 
        755                 760                 765             


Asp Ser Ile Pro His Ala Pro Val Pro Ala Gln Thr Val Leu Leu Thr 
    770                 775                 780                 


Gly Ala Asn Gly Tyr Leu Gly Arg Phe Leu Cys Leu Glu Trp Leu Glu 
785                 790                 795                 800 


Arg Leu Asp Lys Thr Gly Gly Thr Leu Ile Cys Val Val Arg Gly Ser 
                805                 810                 815     


Asp Ala Ala Ala Ala Arg Lys Arg Leu Asp Ser Ala Phe Asp Ser Gly 
            820                 825                 830         


Asp Pro Gly Leu Leu Glu His Tyr Gln Gln Leu Ala Ala Arg Thr Leu 
        835                 840                 845             


Glu Val Leu Ala Gly Asp Ile Gly Asp Pro Asn Leu Gly Leu Asp Asp 
    850                 855                 860                 


Ala Thr Trp Gln Arg Leu Ala Glu Thr Val Asp Leu Ile Val His Pro 
865                 870                 875                 880 


Ala Ala Leu Val Asn His Val Leu Pro Tyr Thr Gln Leu Phe Gly Pro 
                885                 890                 895     


Asn Val Val Gly Thr Ala Glu Ile Val Arg Leu Ala Ile Thr Ala Arg 
            900                 905                 910         


Arg Lys Pro Val Thr Tyr Leu Ser Thr Val Gly Val Ala Asp Gln Val 
        915                 920                 925             


Asp Pro Ala Glu Tyr Gln Glu Asp Ser Asp Val Arg Glu Met Ser Ala 
    930                 935                 940                 


Val Arg Val Val Arg Glu Ser Tyr Ala Asn Gly Tyr Gly Asn Ser Lys 
945                 950                 955                 960 


Trp Ala Gly Glu Val Leu Leu Arg Glu Ala His Asp Leu Cys Gly Leu 
                965                 970                 975     


Pro Val Ala Val Phe Arg Ser Asp Met Ile Leu Ala His Ser Arg Tyr 
            980                 985                 990         


Ala Gly Gln Leu Asn Val Gln Asp  Val Phe Thr Arg Leu  Ile Leu Ser 
        995                 1000                 1005             


Leu Val  Ala Thr Gly Ile Ala  Pro Tyr Ser Phe Tyr  Arg Thr Asp 
    1010                 1015                 1020             


Ala Asp  Gly Asn Arg Gln Arg  Ala His Tyr Asp Gly  Leu Pro Ala 
    1025                 1030                 1035             


Asp Phe  Thr Ala Ala Ala Ile  Thr Ala Leu Gly Ile  Gln Ala Thr 
    1040                 1045                 1050             


Glu Gly  Phe Arg Thr Tyr Asp  Val Leu Asn Pro Tyr  Asp Asp Gly 
    1055                 1060                 1065             


Ile Ser  Leu Asp Glu Phe Val  Asp Trp Leu Val Glu  Ser Gly His 
    1070                 1075                 1080             


Pro Ile  Gln Arg Ile Thr Asp  Tyr Ser Asp Trp Phe  His Arg Phe 
    1085                 1090                 1095             


Glu Thr  Ala Ile Arg Ala Leu  Pro Glu Lys Gln Arg  Gln Ala Ser 
    1100                 1105                 1110             


Val Leu  Pro Leu Leu Asp Ala  Tyr Arg Asn Pro Cys  Pro Ala Val 
    1115                 1120                 1125             


Arg Gly  Ala Ile Leu Pro Ala  Lys Glu Phe Gln Ala  Ala Val Gln 
    1130                 1135                 1140             


Thr Ala  Lys Ile Gly Pro Glu  Gln Asp Ile Pro His  Leu Ser Ala 
    1145                 1150                 1155             


Pro Leu  Ile Asp Lys Tyr Val  Ser Asp Leu Glu Leu  Leu Gln Leu 
    1160                 1165                 1170             


Leu 
    


<210> 3
<211> 669
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      codon optimized phosphpantetheine transferase
      polynucleotide

<400> 3
atgattgaaa ccattctgcc tgcaggcgtt gaaagcgcag aactgctgga atatccggaa       60

gatctgaaag cacatccggc agaagaacat ctgattgcca aaagcgttga aaaacgtcgt      120

cgtgatttta ttggtgcacg tcattgtgca cgtctggcac tggcagaact gggtgaacct      180

ccggttgcaa ttggtaaagg tgaacgtggt gcaccgattt ggcctcgtgg tgttgttggt      240

agcctgaccc attgtgatgg ttatcgtgca gcagcagttg cacataaaat gcgctttcgc      300

agcattggta ttgatgcaga accgcatgca accctgccgg aaggtgttct ggatagcgtt      360

agcctgccgc cggaacgtga atggctgaaa accaccgata gcgcactgca tctggatcgt      420

ctgctgtttt gtgcaaaaga agccacctat aaagcctggt ggccgctgac agcacgttgg      480

ctgggttttg aagaagccca tattaccttt gaaattgaag atggtagcgc agatagcggt      540

aatggcacct ttcatagcga actgctggtt ccgggtcaga ccaatgatgg tggtacaccg      600

ctgctgagct ttgatggtcg ttggctgatt gcagatggtt ttattctgac cgcaattgcc      660

tatgcctaa                                                              669


<210> 4
<211> 222
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      codon optimized phosphpantetheine transferase
      polypeptide

<400> 4
Met Ile Glu Thr Ile Leu Pro Ala Gly Val Glu Ser Ala Glu Leu Leu 
1               5                   10                  15      


Glu Tyr Pro Glu Asp Leu Lys Ala His Pro Ala Glu Glu His Leu Ile 
            20                  25                  30          


Ala Lys Ser Val Glu Lys Arg Arg Arg Asp Phe Ile Gly Ala Arg His 
        35                  40                  45              


Cys Ala Arg Leu Ala Leu Ala Glu Leu Gly Glu Pro Pro Val Ala Ile 
    50                  55                  60                  


Gly Lys Gly Glu Arg Gly Ala Pro Ile Trp Pro Arg Gly Val Val Gly 
65                  70                  75                  80  


Ser Leu Thr His Cys Asp Gly Tyr Arg Ala Ala Ala Val Ala His Lys 
                85                  90                  95      


Met Arg Phe Arg Ser Ile Gly Ile Asp Ala Glu Pro His Ala Thr Leu 
            100                 105                 110         


Pro Glu Gly Val Leu Asp Ser Val Ser Leu Pro Pro Glu Arg Glu Trp 
        115                 120                 125             


Leu Lys Thr Thr Asp Ser Ala Leu His Leu Asp Arg Leu Leu Phe Cys 
    130                 135                 140                 


Ala Lys Glu Ala Thr Tyr Lys Ala Trp Trp Pro Leu Thr Ala Arg Trp 
145                 150                 155                 160 


Leu Gly Phe Glu Glu Ala His Ile Thr Phe Glu Ile Glu Asp Gly Ser 
                165                 170                 175     


Ala Asp Ser Gly Asn Gly Thr Phe His Ser Glu Leu Leu Val Pro Gly 
            180                 185                 190         


Gln Thr Asn Asp Gly Gly Thr Pro Leu Leu Ser Phe Asp Gly Arg Trp 
        195                 200                 205             


Leu Ile Ala Asp Gly Phe Ile Leu Thr Ala Ile Ala Tyr Ala 
    210                 215                 220         


<210> 5
<211> 3522
<212> DNA
<213> Mycobacterium smegmatis

<400> 5
atgaccagcg atgttcacga cgccacagac ggcgtcaccg aaaccgcact cgacgacgag       60

cagtcgaccc gccgcatcgc cgagctgtac gccaccgatc ccgagttcgc cgccgccgca      120

ccgttgcccg ccgtggtcga cgcggcgcac aaacccgggc tgcggctggc agagatcctg      180

cagaccctgt tcaccggcta cggtgaccgc ccggcgctgg gataccgcgc ccgtgaactg      240

gccaccgacg agggcgggcg caccgtgacg cgtctgctgc cgcggttcga caccctcacc      300

tacgcccagg tgtggtcgcg cgtgcaagcg gtcgccgcgg ccctgcgcca caacttcgcg      360

cagccgatct accccggcga cgccgtcgcg acgatcggtt tcgcgagtcc cgattacctg      420

acgctggatc tcgtatgcgc ctacctgggc ctcgtgagtg ttccgctgca gcacaacgca      480

ccggtcagcc ggctcgcccc gatcctggcc gaggtcgaac cgcggatcct caccgtgagc      540

gccgaatacc tcgacctcgc agtcgaatcc gtgcgggacg tcaactcggt gtcgcagctc      600

gtggtgttcg accatcaccc cgaggtcgac gaccaccgcg acgcactggc ccgcgcgcgt      660

gaacaactcg ccggcaaggg catcgccgtc accaccctgg acgcgatcgc cgacgagggc      720

gccgggctgc cggccgaacc gatctacacc gccgaccatg atcagcgcct cgcgatgatc      780

ctgtacacct cgggttccac cggcgcaccc aagggtgcga tgtacaccga ggcgatggtg      840

gcgcggctgt ggaccatgtc gttcatcacg ggtgacccca cgccggtcat caacgtcaac      900

ttcatgccgc tcaaccacct gggcgggcgc atccccattt ccaccgccgt gcagaacggt      960

ggaaccagtt acttcgtacc ggaatccgac atgtccacgc tgttcgagga tctcgcgctg     1020

gtgcgcccga ccgaactcgg cctggttccg cgcgtcgccg acatgctcta ccagcaccac     1080

ctcgccaccg tcgaccgcct ggtcacgcag ggcgccgacg aactgaccgc cgagaagcag     1140

gccggtgccg aactgcgtga gcaggtgctc ggcggacgcg tgatcaccgg attcgtcagc     1200

accgcaccgc tggccgcgga gatgagggcg ttcctcgaca tcaccctggg cgcacacatc     1260

gtcgacggct acgggctcac cgagaccggc gccgtgacac gcgacggtgt gatcgtgcgg     1320

ccaccggtga tcgactacaa gctgatcgac gttcccgaac tcggctactt cagcaccgac     1380

aagccctacc cgcgtggcga actgctggtc aggtcgcaaa cgctgactcc cgggtactac     1440

aagcgccccg aggtcaccgc gagcgtcttc gaccgggacg gctactacca caccggcgac     1500

gtcatggccg agaccgcacc cgaccacctg gtgtacgtgg accgtcgcaa caacgtcctc     1560

aaactcgcgc agggcgagtt cgtggcggtc gccaacctgg aggcggtgtt ctccggcgcg     1620

gcgctggtgc gccagatctt cgtgtacggc aacagcgagc gcagtttcct tctggccgtg     1680

gtggtcccga cgccggaggc gctcgagcag tacgatccgg ccgcgctcaa ggccgcgctg     1740

gccgactcgc tgcagcgcac cgcacgcgac gccgaactgc aatcctacga ggtgccggcc     1800

gatttcatcg tcgagaccga gccgttcagc gccgccaacg ggctgctgtc gggtgtcgga     1860

aaactgctgc ggcccaacct caaagaccgc tacgggcagc gcctggagca gatgtacgcc     1920

gatatcgcgg ccacgcaggc caaccagttg cgcgaactgc ggcgcgcggc cgccacacaa     1980

ccggtgatcg acaccctcac ccaggccgct gccacgatcc tcggcaccgg gagcgaggtg     2040

gcatccgacg cccacttcac cgacctgggc ggggattccc tgtcggcgct gacactttcg     2100

aacctgctga gcgatttctt cggtttcgaa gttcccgtcg gcaccatcgt gaacccggcc     2160

accaacctcg cccaactcgc ccagcacatc gaggcgcagc gcaccgcggg tgaccgcagg     2220

ccgagtttca ccaccgtgca cggcgcggac gccaccgaga tccgggcgag tgagctgacc     2280

ctggacaagt tcatcgacgc cgaaacgctc cgggccgcac cgggtctgcc caaggtcacc     2340

accgagccac ggacggtgtt gctctcgggc gccaacggct ggctgggccg gttcctcacg     2400

ttgcagtggc tggaacgcct ggcacctgtc ggcggcaccc tcatcacgat cgtgcggggc     2460

cgcgacgacg ccgcggcccg cgcacggctg acccaggcct acgacaccga tcccgagttg     2520

tcccgccgct tcgccgagct ggccgaccgc cacctgcggg tggtcgccgg tgacatcggc     2580

gacccgaatc tgggcctcac acccgagatc tggcaccggc tcgccgccga ggtcgacctg     2640

gtggtgcatc cggcagcgct ggtcaaccac gtgctcccct accggcagct gttcggcccc     2700

aacgtcgtgg gcacggccga ggtgatcaag ctggccctca ccgaacggat caagcccgtc     2760

acgtacctgt ccaccgtgtc ggtggccatg gggatccccg acttcgagga ggacggcgac     2820

atccggaccg tgagcccggt gcgcccgctc gacggcggat acgccaacgg ctacggcaac     2880

agcaagtggg ccggcgaggt gctgctgcgg gaggcccacg atctgtgcgg gctgcccgtg     2940

gcgacgttcc gctcggacat gatcctggcg catccgcgct accgcggtca ggtcaacgtg     3000

ccagacatgt tcacgcgact cctgttgagc ctcttgatca ccggcgtcgc gccgcggtcg     3060

ttctacatcg gagacggtga gcgcccgcgg gcgcactacc ccggcctgac ggtcgatttc     3120

gtggccgagg cggtcacgac gctcggcgcg cagcagcgcg agggatacgt gtcctacgac     3180

gtgatgaacc cgcacgacga cgggatctcc ctggatgtgt tcgtggactg gctgatccgg     3240

gcgggccatc cgatcgaccg ggtcgacgac tacgacgact gggtgcgtcg gttcgagacc     3300

gcgttgaccg cgcttcccga gaagcgccgc gcacagaccg tactgccgct gctgcacgcg     3360

ttccgcgctc cgcaggcacc gttgcgcggc gcacccgaac ccacggaggt gttccacgcc     3420

gcggtgcgca ccgcgaaggt gggcccggga gacatcccgc acctcgacga ggcgctgatc     3480

gacaagtaca tacgcgatct gcgtgagttc ggtctgatct aa                        3522


<210> 6
<211> 1173
<212> PRT
<213> Mycobacterium smegmatis

<400> 6
Met Thr Ser Asp Val His Asp Ala Thr Asp Gly Val Thr Glu Thr Ala 
1               5                   10                  15      


Leu Asp Asp Glu Gln Ser Thr Arg Arg Ile Ala Glu Leu Tyr Ala Thr 
            20                  25                  30          


Asp Pro Glu Phe Ala Ala Ala Ala Pro Leu Pro Ala Val Val Asp Ala 
        35                  40                  45              


Ala His Lys Pro Gly Leu Arg Leu Ala Glu Ile Leu Gln Thr Leu Phe 
    50                  55                  60                  


Thr Gly Tyr Gly Asp Arg Pro Ala Leu Gly Tyr Arg Ala Arg Glu Leu 
65                  70                  75                  80  


Ala Thr Asp Glu Gly Gly Arg Thr Val Thr Arg Leu Leu Pro Arg Phe 
                85                  90                  95      


Asp Thr Leu Thr Tyr Ala Gln Val Trp Ser Arg Val Gln Ala Val Ala 
            100                 105                 110         


Ala Ala Leu Arg His Asn Phe Ala Gln Pro Ile Tyr Pro Gly Asp Ala 
        115                 120                 125             


Val Ala Thr Ile Gly Phe Ala Ser Pro Asp Tyr Leu Thr Leu Asp Leu 
    130                 135                 140                 


Val Cys Ala Tyr Leu Gly Leu Val Ser Val Pro Leu Gln His Asn Ala 
145                 150                 155                 160 


Pro Val Ser Arg Leu Ala Pro Ile Leu Ala Glu Val Glu Pro Arg Ile 
                165                 170                 175     


Leu Thr Val Ser Ala Glu Tyr Leu Asp Leu Ala Val Glu Ser Val Arg 
            180                 185                 190         


Asp Val Asn Ser Val Ser Gln Leu Val Val Phe Asp His His Pro Glu 
        195                 200                 205             


Val Asp Asp His Arg Asp Ala Leu Ala Arg Ala Arg Glu Gln Leu Ala 
    210                 215                 220                 


Gly Lys Gly Ile Ala Val Thr Thr Leu Asp Ala Ile Ala Asp Glu Gly 
225                 230                 235                 240 


Ala Gly Leu Pro Ala Glu Pro Ile Tyr Thr Ala Asp His Asp Gln Arg 
                245                 250                 255     


Leu Ala Met Ile Leu Tyr Thr Ser Gly Ser Thr Gly Ala Pro Lys Gly 
            260                 265                 270         


Ala Met Tyr Thr Glu Ala Met Val Ala Arg Leu Trp Thr Met Ser Phe 
        275                 280                 285             


Ile Thr Gly Asp Pro Thr Pro Val Ile Asn Val Asn Phe Met Pro Leu 
    290                 295                 300                 


Asn His Leu Gly Gly Arg Ile Pro Ile Ser Thr Ala Val Gln Asn Gly 
305                 310                 315                 320 


Gly Thr Ser Tyr Phe Val Pro Glu Ser Asp Met Ser Thr Leu Phe Glu 
                325                 330                 335     


Asp Leu Ala Leu Val Arg Pro Thr Glu Leu Gly Leu Val Pro Arg Val 
            340                 345                 350         


Ala Asp Met Leu Tyr Gln His His Leu Ala Thr Val Asp Arg Leu Val 
        355                 360                 365             


Thr Gln Gly Ala Asp Glu Leu Thr Ala Glu Lys Gln Ala Gly Ala Glu 
    370                 375                 380                 


Leu Arg Glu Gln Val Leu Gly Gly Arg Val Ile Thr Gly Phe Val Ser 
385                 390                 395                 400 


Thr Ala Pro Leu Ala Ala Glu Met Arg Ala Phe Leu Asp Ile Thr Leu 
                405                 410                 415     


Gly Ala His Ile Val Asp Gly Tyr Gly Leu Thr Glu Thr Gly Ala Val 
            420                 425                 430         


Thr Arg Asp Gly Val Ile Val Arg Pro Pro Val Ile Asp Tyr Lys Leu 
        435                 440                 445             


Ile Asp Val Pro Glu Leu Gly Tyr Phe Ser Thr Asp Lys Pro Tyr Pro 
    450                 455                 460                 


Arg Gly Glu Leu Leu Val Arg Ser Gln Thr Leu Thr Pro Gly Tyr Tyr 
465                 470                 475                 480 


Lys Arg Pro Glu Val Thr Ala Ser Val Phe Asp Arg Asp Gly Tyr Tyr 
                485                 490                 495     


His Thr Gly Asp Val Met Ala Glu Thr Ala Pro Asp His Leu Val Tyr 
            500                 505                 510         


Val Asp Arg Arg Asn Asn Val Leu Lys Leu Ala Gln Gly Glu Phe Val 
        515                 520                 525             


Ala Val Ala Asn Leu Glu Ala Val Phe Ser Gly Ala Ala Leu Val Arg 
    530                 535                 540                 


Gln Ile Phe Val Tyr Gly Asn Ser Glu Arg Ser Phe Leu Leu Ala Val 
545                 550                 555                 560 


Val Val Pro Thr Pro Glu Ala Leu Glu Gln Tyr Asp Pro Ala Ala Leu 
                565                 570                 575     


Lys Ala Ala Leu Ala Asp Ser Leu Gln Arg Thr Ala Arg Asp Ala Glu 
            580                 585                 590         


Leu Gln Ser Tyr Glu Val Pro Ala Asp Phe Ile Val Glu Thr Glu Pro 
        595                 600                 605             


Phe Ser Ala Ala Asn Gly Leu Leu Ser Gly Val Gly Lys Leu Leu Arg 
    610                 615                 620                 


Pro Asn Leu Lys Asp Arg Tyr Gly Gln Arg Leu Glu Gln Met Tyr Ala 
625                 630                 635                 640 


Asp Ile Ala Ala Thr Gln Ala Asn Gln Leu Arg Glu Leu Arg Arg Ala 
                645                 650                 655     


Ala Ala Thr Gln Pro Val Ile Asp Thr Leu Thr Gln Ala Ala Ala Thr 
            660                 665                 670         


Ile Leu Gly Thr Gly Ser Glu Val Ala Ser Asp Ala His Phe Thr Asp 
        675                 680                 685             


Leu Gly Gly Asp Ser Leu Ser Ala Leu Thr Leu Ser Asn Leu Leu Ser 
    690                 695                 700                 


Asp Phe Phe Gly Phe Glu Val Pro Val Gly Thr Ile Val Asn Pro Ala 
705                 710                 715                 720 


Thr Asn Leu Ala Gln Leu Ala Gln His Ile Glu Ala Gln Arg Thr Ala 
                725                 730                 735     


Gly Asp Arg Arg Pro Ser Phe Thr Thr Val His Gly Ala Asp Ala Thr 
            740                 745                 750         


Glu Ile Arg Ala Ser Glu Leu Thr Leu Asp Lys Phe Ile Asp Ala Glu 
        755                 760                 765             


Thr Leu Arg Ala Ala Pro Gly Leu Pro Lys Val Thr Thr Glu Pro Arg 
    770                 775                 780                 


Thr Val Leu Leu Ser Gly Ala Asn Gly Trp Leu Gly Arg Phe Leu Thr 
785                 790                 795                 800 


Leu Gln Trp Leu Glu Arg Leu Ala Pro Val Gly Gly Thr Leu Ile Thr 
                805                 810                 815     


Ile Val Arg Gly Arg Asp Asp Ala Ala Ala Arg Ala Arg Leu Thr Gln 
            820                 825                 830         


Ala Tyr Asp Thr Asp Pro Glu Leu Ser Arg Arg Phe Ala Glu Leu Ala 
        835                 840                 845             


Asp Arg His Leu Arg Val Val Ala Gly Asp Ile Gly Asp Pro Asn Leu 
    850                 855                 860                 


Gly Leu Thr Pro Glu Ile Trp His Arg Leu Ala Ala Glu Val Asp Leu 
865                 870                 875                 880 


Val Val His Pro Ala Ala Leu Val Asn His Val Leu Pro Tyr Arg Gln 
                885                 890                 895     


Leu Phe Gly Pro Asn Val Val Gly Thr Ala Glu Val Ile Lys Leu Ala 
            900                 905                 910         


Leu Thr Glu Arg Ile Lys Pro Val Thr Tyr Leu Ser Thr Val Ser Val 
        915                 920                 925             


Ala Met Gly Ile Pro Asp Phe Glu Glu Asp Gly Asp Ile Arg Thr Val 
    930                 935                 940                 


Ser Pro Val Arg Pro Leu Asp Gly Gly Tyr Ala Asn Gly Tyr Gly Asn 
945                 950                 955                 960 


Ser Lys Trp Ala Gly Glu Val Leu Leu Arg Glu Ala His Asp Leu Cys 
                965                 970                 975     


Gly Leu Pro Val Ala Thr Phe Arg Ser Asp Met Ile Leu Ala His Pro 
            980                 985                 990         


Arg Tyr Arg Gly Gln Val Asn Val  Pro Asp Met Phe Thr  Arg Leu Leu 
        995                 1000                 1005             


Leu Ser  Leu Leu Ile Thr Gly  Val Ala Pro Arg Ser  Phe Tyr Ile 
    1010                 1015                 1020             


Gly Asp  Gly Glu Arg Pro Arg  Ala His Tyr Pro Gly  Leu Thr Val 
    1025                 1030                 1035             


Asp Phe  Val Ala Glu Ala Val  Thr Thr Leu Gly Ala  Gln Gln Arg 
    1040                 1045                 1050             


Glu Gly  Tyr Val Ser Tyr Asp  Val Met Asn Pro His  Asp Asp Gly 
    1055                 1060                 1065             


Ile Ser  Leu Asp Val Phe Val  Asp Trp Leu Ile Arg  Ala Gly His 
    1070                 1075                 1080             


Pro Ile  Asp Arg Val Asp Asp  Tyr Asp Asp Trp Val  Arg Arg Phe 
    1085                 1090                 1095             


Glu Thr  Ala Leu Thr Ala Leu  Pro Glu Lys Arg Arg  Ala Gln Thr 
    1100                 1105                 1110             


Val Leu  Pro Leu Leu His Ala  Phe Arg Ala Pro Gln  Ala Pro Leu 
    1115                 1120                 1125             


Arg Gly  Ala Pro Glu Pro Thr  Glu Val Phe His Ala  Ala Val Arg 
    1130                 1135                 1140             


Thr Ala  Lys Val Gly Pro Gly  Asp Ile Pro His Leu  Asp Glu Ala 
    1145                 1150                 1155             


Leu Ile  Asp Lys Tyr Ile Arg  Asp Leu Arg Glu Phe  Gly Leu Ile 
    1160                 1165                 1170             


<210> 7
<211> 3522
<212> DNA
<213> Mycobacterium avium

<400> 7
atgtcgactg ccacccatga cgaacgactc gaccgtcgcg tccacgaact catcgccacc       60

gacccgcaat tcgccgccgc ccaacccgac ccggcgatca ccgccgccct cgaacagccc      120

gggctgcggc tgccgcagat catccgcacc gtgctcgacg gctacgccga ccggccggcg      180

ctgggacagc gcgtggtgga gttcgtcacg gacgccaaga ccgggcgcac gtcggcgcag      240

ctgctccccc gcttcgagac catcacgtac agcgaagtag cgcagcgtgt ttcggcgctg      300

ggccgcgccc tgtccgacga cgcggtgcac cccggcgacc gggtgtgcgt gctgggcttc      360

aacagcgtcg actacgccac catcgacatg gcgctgggcg ccatcggcgc cgtctcggtg      420

ccgctgcaga ccagcgcggc aatcagctcg ctgcagccga tcgtggccga gaccgagccc      480

accctgatcg cgtccagcgt gaaccagctg tccgacgcgg tgcagctgat caccggcgcc      540

gagcaggcgc ccacccggct ggtggtgttc gactaccacc cgcaggtcga cgaccagcgc      600

gaggccgtcc aggacgccgc ggcgcggctg tccagcaccg gcgtggccgt ccagacgctg      660

gccgagctgc tggagcgcgg caaggacctg cccgccgtcg cggagccgcc cgccgacgag      720

gactcgctgg ccctgctgat ctacacctcc gggtccaccg gcgcccccaa gggcgcgatg      780

tacccacaga gcaacgtcgg caagatgtgg cgccgcggca gcaagaactg gttcggcgag      840

agcgccgcgt cgatcaccct gaacttcatg ccgatgagcc acgtgatggg ccgaagcatc      900

ctctacggca cgctgggcaa cggcggcacc gcctacttcg ccgcccgcag cgacctgtcc      960

accctgcttg aggacctcga gctggtgcgg cccaccgagc tcaacttcgt cccgcggatc     1020

tgggagacgc tgtacggcga attccagcgt caggtcgagc ggcggctctc cgaggccggg     1080

gacgccggcg aacgtcgcgc cgtcgaggcc gaggtgctgg ccgagcagcg ccagtacctg     1140

ctgggcgggc ggttcacctt cgcgatgacg ggctcggcgc ccatctcgcc ggagctgcgc     1200

aactgggtcg agtcgctgct cgaaatgcac ctgatggacg gctacggctc caccgaggcc     1260

ggaatggtgt tgttcgacgg ggagattcag cgcccgccgg tgatcgacta caagctggtc     1320

gacgtgccgg acctgggcta cttcagcacc gaccggccgc atccgcgcgg cgagctgctg     1380

ctgcgcaccg agaacatgtt cccgggctac tacaagcggg ccgaaaccac cgcgggcgtc     1440

ttcgacgagg acggctacta ccgcaccggc gacgtgttcg ccgagatcgc cccggaccgg     1500

ctggtctacg tcgaccgccg caacaacgtg ctcaagctgg cgcagggcga attcgtcacg     1560

ctggccaagc tggaggcggt gttcggcaac agcccgctga tccgccagat ctacgtctac     1620

ggcaacagcg cccagcccta cctgctggcg gtcgtggtgc ccaccgagga ggcgctggcc     1680

tcgggtgacc ccgagacgct caagcccaag atcgccgact cgctgcagca ggtcgccaag     1740

gaggccggcc tgcagtccta cgaggtgccg cgcgacttca tcatcgagac caccccgttc     1800

agcctggaaa acggtctgct gaccgggatc cggaagctgg cgtggccgaa actgaagcag     1860

cactacgggg aacggctgga gcagatgtac gccgacctgg ccgccggaca ggccaacgag     1920

ctggccgagc tgcgccgcaa cggtgcccag gcgccggtgt tgcagaccgt gagccgcgcc     1980

gcgggcgcca tgctgggttc ggccgcctcc gacctgtccc ccgacgccca cttcaccgat     2040

ctgggcggag actcgttgtc ggcgttgaca ttcggcaacc tgctgcgcga gatcttcgac     2100

gtcgacgtgc cggtaggcgt gatcgtcagc ccggccaacg acctggcggc catcgcgagc     2160

tacatcgagg ccgagcggca gggcagcaag cgcccgacgt tcgcctcggt gcacggccgg     2220

gacgcgaccg tggtgcgcgc cgccgacctg acgctggaca agttcctcga cgccgagacg     2280

ctggccgccg cgccgaacct gcccaagccg gccaccgagg tgcgcaccgt gctgctgacc     2340

ggcgccaccg gcttcctggg ccgctacctg gccctggaat ggctggagcg gatggacatg     2400

gtggacggca aggtcatcgc cctggtccgg gcccgctccg acgaggaggc acgcgcccgg     2460

ctggacaaga ccttcgacag cggcgacccg aaactgctcg cgcactacca gcagctggcc     2520

gccgatcacc tggaggtcat cgccggcgac aagggcgagg ccaatctggg cctgggccaa     2580

gacgtttggc aacgactggc cgacacggtc gacgtgatcg tcgaccccgc cgcgctggtc     2640

aaccacgtgt tgccgtacag cgagctgttc gggcccaacg ccctgggcac cgcggagctg     2700

atccggctgg cgctgacgtc caagcagaag ccgtacacct acgtgtccac catcggcgtg     2760

ggcgaccaga tcgagccggg caagttcgtc gagaacgccg acatccggca gatgagcgcc     2820

acccgggcga tcaacgacag ctacgccaac ggctatggca acagcaagtg ggccggcgag     2880

gtgctgctgc gcgaggcgca cgacctgtgc gggctgcccg tcgcggtgtt ccgctgcgac     2940

atgatcctgg ccgacaccac gtatgccggg cagctcaacc tgccggacat gttcacccgg     3000

ctgatgctga gcctggtggc caccgggatc gcgcccggct cgttctacga gctcgacgcc     3060

gacggcaacc ggcagcgggc gcactacgac ggcctgccgg tcgagttcat cgccgcggcg     3120

atctcgacgc tgggttcgca gatcaccgac agcgacaccg gcttccagac ctaccacgtg     3180

atgaacccct acgatgacgg cgtcggtctg gacgagtacg tcgattggct ggtggacgcc     3240

ggctattcga tcgagcggat cgccgactac tccgaatggc tgcggcggtt cgagacctcg     3300

ctgcgggccc tgccggaccg gcagcgccag tactcgctgc tgccgctgct gcacaactac     3360

cgcacgccgg agaagccgat caacgggtcg atagctccca ccgacgtgtt ccgggcagcg     3420

gtgcaggagg cgaaaatcgg ccccgacaaa gacattccgc acgtgtcgcc gccggtcatc     3480

gtcaagtaca tcaccgacct gcagctgctc gggctgctct aa                        3522


<210> 8
<211> 1173
<212> PRT
<213> Mycobacterium avium

<400> 8
Met Ser Thr Ala Thr His Asp Glu Arg Leu Asp Arg Arg Val His Glu 
1               5                   10                  15      


Leu Ile Ala Thr Asp Pro Gln Phe Ala Ala Ala Gln Pro Asp Pro Ala 
            20                  25                  30          


Ile Thr Ala Ala Leu Glu Gln Pro Gly Leu Arg Leu Pro Gln Ile Ile 
        35                  40                  45              


Arg Thr Val Leu Asp Gly Tyr Ala Asp Arg Pro Ala Leu Gly Gln Arg 
    50                  55                  60                  


Val Val Glu Phe Val Thr Asp Ala Lys Thr Gly Arg Thr Ser Ala Gln 
65                  70                  75                  80  


Leu Leu Pro Arg Phe Glu Thr Ile Thr Tyr Ser Glu Val Ala Gln Arg 
                85                  90                  95      


Val Ser Ala Leu Gly Arg Ala Leu Ser Asp Asp Ala Val His Pro Gly 
            100                 105                 110         


Asp Arg Val Cys Val Leu Gly Phe Asn Ser Val Asp Tyr Ala Thr Ile 
        115                 120                 125             


Asp Met Ala Leu Gly Ala Ile Gly Ala Val Ser Val Pro Leu Gln Thr 
    130                 135                 140                 


Ser Ala Ala Ile Ser Ser Leu Gln Pro Ile Val Ala Glu Thr Glu Pro 
145                 150                 155                 160 


Thr Leu Ile Ala Ser Ser Val Asn Gln Leu Ser Asp Ala Val Gln Leu 
                165                 170                 175     


Ile Thr Gly Ala Glu Gln Ala Pro Thr Arg Leu Val Val Phe Asp Tyr 
            180                 185                 190         


His Pro Gln Val Asp Asp Gln Arg Glu Ala Val Gln Asp Ala Ala Ala 
        195                 200                 205             


Arg Leu Ser Ser Thr Gly Val Ala Val Gln Thr Leu Ala Glu Leu Leu 
    210                 215                 220                 


Glu Arg Gly Lys Asp Leu Pro Ala Val Ala Glu Pro Pro Ala Asp Glu 
225                 230                 235                 240 


Asp Ser Leu Ala Leu Leu Ile Tyr Thr Ser Gly Ser Thr Gly Ala Pro 
                245                 250                 255     


Lys Gly Ala Met Tyr Pro Gln Ser Asn Val Gly Lys Met Trp Arg Arg 
            260                 265                 270         


Gly Ser Lys Asn Trp Phe Gly Glu Ser Ala Ala Ser Ile Thr Leu Asn 
        275                 280                 285             


Phe Met Pro Met Ser His Val Met Gly Arg Ser Ile Leu Tyr Gly Thr 
    290                 295                 300                 


Leu Gly Asn Gly Gly Thr Ala Tyr Phe Ala Ala Arg Ser Asp Leu Ser 
305                 310                 315                 320 


Thr Leu Leu Glu Asp Leu Glu Leu Val Arg Pro Thr Glu Leu Asn Phe 
                325                 330                 335     


Val Pro Arg Ile Trp Glu Thr Leu Tyr Gly Glu Phe Gln Arg Gln Val 
            340                 345                 350         


Glu Arg Arg Leu Ser Glu Ala Gly Asp Ala Gly Glu Arg Arg Ala Val 
        355                 360                 365             


Glu Ala Glu Val Leu Ala Glu Gln Arg Gln Tyr Leu Leu Gly Gly Arg 
    370                 375                 380                 


Phe Thr Phe Ala Met Thr Gly Ser Ala Pro Ile Ser Pro Glu Leu Arg 
385                 390                 395                 400 


Asn Trp Val Glu Ser Leu Leu Glu Met His Leu Met Asp Gly Tyr Gly 
                405                 410                 415     


Ser Thr Glu Ala Gly Met Val Leu Phe Asp Gly Glu Ile Gln Arg Pro 
            420                 425                 430         


Pro Val Ile Asp Tyr Lys Leu Val Asp Val Pro Asp Leu Gly Tyr Phe 
        435                 440                 445             


Ser Thr Asp Arg Pro His Pro Arg Gly Glu Leu Leu Leu Arg Thr Glu 
    450                 455                 460                 


Asn Met Phe Pro Gly Tyr Tyr Lys Arg Ala Glu Thr Thr Ala Gly Val 
465                 470                 475                 480 


Phe Asp Glu Asp Gly Tyr Tyr Arg Thr Gly Asp Val Phe Ala Glu Ile 
                485                 490                 495     


Ala Pro Asp Arg Leu Val Tyr Val Asp Arg Arg Asn Asn Val Leu Lys 
            500                 505                 510         


Leu Ala Gln Gly Glu Phe Val Thr Leu Ala Lys Leu Glu Ala Val Phe 
        515                 520                 525             


Gly Asn Ser Pro Leu Ile Arg Gln Ile Tyr Val Tyr Gly Asn Ser Ala 
    530                 535                 540                 


Gln Pro Tyr Leu Leu Ala Val Val Val Pro Thr Glu Glu Ala Leu Ala 
545                 550                 555                 560 


Ser Gly Asp Pro Glu Thr Leu Lys Pro Lys Ile Ala Asp Ser Leu Gln 
                565                 570                 575     


Gln Val Ala Lys Glu Ala Gly Leu Gln Ser Tyr Glu Val Pro Arg Asp 
            580                 585                 590         


Phe Ile Ile Glu Thr Thr Pro Phe Ser Leu Glu Asn Gly Leu Leu Thr 
        595                 600                 605             


Gly Ile Arg Lys Leu Ala Trp Pro Lys Leu Lys Gln His Tyr Gly Glu 
    610                 615                 620                 


Arg Leu Glu Gln Met Tyr Ala Asp Leu Ala Ala Gly Gln Ala Asn Glu 
625                 630                 635                 640 


Leu Ala Glu Leu Arg Arg Asn Gly Ala Gln Ala Pro Val Leu Gln Thr 
                645                 650                 655     


Val Ser Arg Ala Ala Gly Ala Met Leu Gly Ser Ala Ala Ser Asp Leu 
            660                 665                 670         


Ser Pro Asp Ala His Phe Thr Asp Leu Gly Gly Asp Ser Leu Ser Ala 
        675                 680                 685             


Leu Thr Phe Gly Asn Leu Leu Arg Glu Ile Phe Asp Val Asp Val Pro 
    690                 695                 700                 


Val Gly Val Ile Val Ser Pro Ala Asn Asp Leu Ala Ala Ile Ala Ser 
705                 710                 715                 720 


Tyr Ile Glu Ala Glu Arg Gln Gly Ser Lys Arg Pro Thr Phe Ala Ser 
                725                 730                 735     


Val His Gly Arg Asp Ala Thr Val Val Arg Ala Ala Asp Leu Thr Leu 
            740                 745                 750         


Asp Lys Phe Leu Asp Ala Glu Thr Leu Ala Ala Ala Pro Asn Leu Pro 
        755                 760                 765             


Lys Pro Ala Thr Glu Val Arg Thr Val Leu Leu Thr Gly Ala Thr Gly 
    770                 775                 780                 


Phe Leu Gly Arg Tyr Leu Ala Leu Glu Trp Leu Glu Arg Met Asp Met 
785                 790                 795                 800 


Val Asp Gly Lys Val Ile Ala Leu Val Arg Ala Arg Ser Asp Glu Glu 
                805                 810                 815     


Ala Arg Ala Arg Leu Asp Lys Thr Phe Asp Ser Gly Asp Pro Lys Leu 
            820                 825                 830         


Leu Ala His Tyr Gln Gln Leu Ala Ala Asp His Leu Glu Val Ile Ala 
        835                 840                 845             


Gly Asp Lys Gly Glu Ala Asn Leu Gly Leu Gly Gln Asp Val Trp Gln 
    850                 855                 860                 


Arg Leu Ala Asp Thr Val Asp Val Ile Val Asp Pro Ala Ala Leu Val 
865                 870                 875                 880 


Asn His Val Leu Pro Tyr Ser Glu Leu Phe Gly Pro Asn Ala Leu Gly 
                885                 890                 895     


Thr Ala Glu Leu Ile Arg Leu Ala Leu Thr Ser Lys Gln Lys Pro Tyr 
            900                 905                 910         


Thr Tyr Val Ser Thr Ile Gly Val Gly Asp Gln Ile Glu Pro Gly Lys 
        915                 920                 925             


Phe Val Glu Asn Ala Asp Ile Arg Gln Met Ser Ala Thr Arg Ala Ile 
    930                 935                 940                 


Asn Asp Ser Tyr Ala Asn Gly Tyr Gly Asn Ser Lys Trp Ala Gly Glu 
945                 950                 955                 960 


Val Leu Leu Arg Glu Ala His Asp Leu Cys Gly Leu Pro Val Ala Val 
                965                 970                 975     


Phe Arg Cys Asp Met Ile Leu Ala Asp Thr Thr Tyr Ala Gly Gln Leu 
            980                 985                 990         


Asn Leu Pro Asp Met Phe Thr Arg  Leu Met Leu Ser Leu  Val Ala Thr 
        995                 1000                 1005             


Gly Ile  Ala Pro Gly Ser Phe  Tyr Glu Leu Asp Ala  Asp Gly Asn 
    1010                 1015                 1020             


Arg Gln  Arg Ala His Tyr Asp  Gly Leu Pro Val Glu  Phe Ile Ala 
    1025                 1030                 1035             


Ala Ala  Ile Ser Thr Leu Gly  Ser Gln Ile Thr Asp  Ser Asp Thr 
    1040                 1045                 1050             


Gly Phe  Gln Thr Tyr His Val  Met Asn Pro Tyr Asp  Asp Gly Val 
    1055                 1060                 1065             


Gly Leu  Asp Glu Tyr Val Asp  Trp Leu Val Asp Ala  Gly Tyr Ser 
    1070                 1075                 1080             


Ile Glu  Arg Ile Ala Asp Tyr  Ser Glu Trp Leu Arg  Arg Phe Glu 
    1085                 1090                 1095             


Thr Ser  Leu Arg Ala Leu Pro  Asp Arg Gln Arg Gln  Tyr Ser Leu 
    1100                 1105                 1110             


Leu Pro  Leu Leu His Asn Tyr  Arg Thr Pro Glu Lys  Pro Ile Asn 
    1115                 1120                 1125             


Gly Ser  Ile Ala Pro Thr Asp  Val Phe Arg Ala Ala  Val Gln Glu 
    1130                 1135                 1140             


Ala Lys  Ile Gly Pro Asp Lys  Asp Ile Pro His Val  Ser Pro Pro 
    1145                 1150                 1155             


Val Ile  Val Lys Tyr Ile Thr  Asp Leu Gln Leu Leu  Gly Leu Leu 
    1160                 1165                 1170             


<210> 9
<211> 3525
<212> DNA
<213> Mycobacterium marinum

<400> 9
atgtcgccaa tcacgcgtga agagcggctc gagcgccgca tccaggacct ctacgccaac       60

gacccgcagt tcgccgccgc caaacccgcc acggcgatca ccgcagcaat cgagcggccg      120

ggtctaccgc taccccagat catcgagacc gtcatgaccg gatacgccga tcggccggct      180

ctcgctcagc gctcggtcga attcgtgacc gacgccggca ccggccacac cacgctgcga      240

ctgctccccc acttcgaaac catcagctac ggcgagcttt gggaccgcat cagcgcactg      300

gccgacgtgc tcagcaccga acagacggtg aaaccgggcg accgggtctg cttgttgggc      360

ttcaacagcg tcgactacgc cacgatcgac atgactttgg cgcggctggg cgcggtggcc      420

gtaccactgc agaccagcgc ggcgataacc cagctgcagc cgatcgtcgc cgagacccag      480

cccaccatga tcgcggccag cgtcgacgca ctcgctgacg ccaccgaatt ggctctgtcc      540

ggtcagaccg ctacccgagt cctggtgttc gaccaccacc ggcaggttga cgcacaccgc      600

gcagcggtcg aatccgcccg ggagcgcctg gccggctcgg cggtcgtcga aaccctggcc      660

gaggccatcg cgcgcggcga cgtgccccgc ggtgcgtccg ccggctcggc gcccggcacc      720

gatgtgtccg acgactcgct cgcgctactg atctacacct cgggcagcac gggtgcgccc      780

aagggcgcga tgtacccccg acgcaacgtt gcgaccttct ggcgcaagcg cacctggttc      840

gaaggcggct acgagccgtc gatcacgctg aacttcatgc caatgagcca cgtcatgggc      900

cgccaaatcc tgtacggcac gctgtgcaat ggcggcaccg cctacttcgt ggcgaaaagc      960

gatctctcca ccttgttcga agacctggcg ctggtgcggc ccaccgagct gaccttcgtg     1020

ccgcgcgtgt gggacatggt gttcgacgag tttcagagtg aggtcgaccg ccgcctggtc     1080

gacggcgccg accgggtcgc gctcgaagcc caggtcaagg ccgagatacg caacgacgtg     1140

ctcggtggac ggtataccag cgcactgacc ggctccgccc ctatctccga cgagatgaag     1200

gcgtgggtcg aggagctgct cgacatgcat ctggtcgagg gctacggctc caccgaggcc     1260

gggatgatcc tgatcgacgg agccattcgg cgcccggcgg tactcgacta caagctggtc     1320

gatgttcccg acctgggtta cttcctgacc gaccggccac atccgcgggg cgagttgctg     1380

gtcaagaccg atagtttgtt cccgggctac taccagcgag ccgaagtcac cgccgacgtg     1440

ttcgatgctg acggcttcta ccggaccggc gacatcatgg ccgaggtcgg ccccgaacag     1500

ttcgtgtacc tcgaccgccg caacaacgtg ttgaagctgt cgcagggcga gttcgtcacc     1560

gtctccaaac tcgaagcggt gtttggcgac agcccactgg tacggcagat ctacatctac     1620

ggcaacagcg cccgtgccta cctgttggcg gtgatcgtcc ccacccagga ggcgctggac     1680

gccgtgcctg tcgaggagct caaggcgcgg ctgggcgact cgctgcaaga ggtcgcaaag     1740

gccgccggcc tgcagtccta cgagatcccg cgcgacttca tcatcgaaac aacaccatgg     1800

acgctggaga acggcctgct caccggcatc cgcaagttgg ccaggccgca gctgaaaaag     1860

cattacggcg agcttctcga gcagatctac acggacctgg cacacggcca ggccgacgaa     1920

ctgcgctcgc tgcgccaaag cggtgccgat gcgccggtgc tggtgacggt gtgccgtgcg     1980

gcggccgcgc tgttgggcgg cagcgcctct gacgtccagc ccgatgcgca cttcaccgat     2040

ttgggcggcg actcgctgtc ggcgctgtcg ttcaccaacc tgctgcacga gatcttcgac     2100

atcgaagtgc cggtgggcgt catcgtcagc cccgccaacg acttgcaggc cctggccgac     2160

tacgtcgagg cggctcgcaa acccggctcg tcacggccga ccttcgcctc ggtccacggc     2220

gcctcgaatg ggcaggtcac cgaggtgcat gccggtgacc tgtccctgga caaattcatc     2280

gatgccgcaa ccctggccga agctccccgg ctgcccgccg caaacaccca agtgcgcacc     2340

gtgctgctga ccggcgccac cggcttcctc gggcgctacc tggccctgga atggctggag     2400

cggatggacc tggtcgacgg caaactgatc tgcctggtcc gggccaagtc cgacaccgaa     2460

gcacgggcgc ggctggacaa gacgttcgac agcggcgacc ccgaactgct ggcccactac     2520

cgcgcactgg ccggcgacca cctcgaggtg ctcgccggtg acaagggcga agccgacctc     2580

ggactggacc ggcagacctg gcaacgcctg gccgacacgg tcgacctgat cgtcgacccc     2640

gcggccctgg tcaaccacgt actgccatac agccagctgt tcgggcccaa cgcgctgggc     2700

accgccgagc tgctgcggct ggcgctcacc tccaagatca agccctacag ctacacctcg     2760

acaatcggtg tcgccgacca gatcccgccg tcggcgttca ccgaggacgc cgacatccgg     2820

gtcatcagcg ccacccgcgc ggtcgacgac agctacgcca atggctactc gaacagcaag     2880

tgggccggcg aggtgctgtt gcgcgaggcg catgacctgt gtggcctgcc ggttgcggtg     2940

ttccgctgcg acatgatcct ggccgacacc acatgggcgg gacagctcaa tgtgccggac     3000

atgttcaccc ggatgatcct gagcctggcg gccaccggta tcgcgccggg ttcgttctat     3060

gagcttgcgg ccgacggcgc ccggcaacgc gcccactatg acggtctgcc cgtcgagttc     3120

atcgccgagg cgatttcgac tttgggtgcg cagagccagg atggtttcca cacgtatcac     3180

gtgatgaacc cctacgacga cggcatcgga ctcgacgagt tcgtcgactg gctcaacgag     3240

tccggttgcc ccatccagcg catcgctgac tatggcgact ggctgcagcg cttcgaaacc     3300

gcactgcgcg cactgcccga tcggcagcgg cacagctcac tgctgccgct gttgcacaac     3360

tatcggcagc cggagcggcc cgtccgcggg tcgatcgccc ctaccgatcg cttccgggca     3420

gcggtgcaag aggccaagat cggccccgac aaagacattc cgcacgtcgg cgcgccgatc     3480

atcgtgaagt acgtcagcga cctgcgccta ctcggcctgc tctaa                     3525


<210> 10
<211> 1174
<212> PRT
<213> Mycobacterium marinum

<400> 10
Met Ser Pro Ile Thr Arg Glu Glu Arg Leu Glu Arg Arg Ile Gln Asp 
1               5                   10                  15      


Leu Tyr Ala Asn Asp Pro Gln Phe Ala Ala Ala Lys Pro Ala Thr Ala 
            20                  25                  30          


Ile Thr Ala Ala Ile Glu Arg Pro Gly Leu Pro Leu Pro Gln Ile Ile 
        35                  40                  45              


Glu Thr Val Met Thr Gly Tyr Ala Asp Arg Pro Ala Leu Ala Gln Arg 
    50                  55                  60                  


Ser Val Glu Phe Val Thr Asp Ala Gly Thr Gly His Thr Thr Leu Arg 
65                  70                  75                  80  


Leu Leu Pro His Phe Glu Thr Ile Ser Tyr Gly Glu Leu Trp Asp Arg 
                85                  90                  95      


Ile Ser Ala Leu Ala Asp Val Leu Ser Thr Glu Gln Thr Val Lys Pro 
            100                 105                 110         


Gly Asp Arg Val Cys Leu Leu Gly Phe Asn Ser Val Asp Tyr Ala Thr 
        115                 120                 125             


Ile Asp Met Thr Leu Ala Arg Leu Gly Ala Val Ala Val Pro Leu Gln 
    130                 135                 140                 


Thr Ser Ala Ala Ile Thr Gln Leu Gln Pro Ile Val Ala Glu Thr Gln 
145                 150                 155                 160 


Pro Thr Met Ile Ala Ala Ser Val Asp Ala Leu Ala Asp Ala Thr Glu 
                165                 170                 175     


Leu Ala Leu Ser Gly Gln Thr Ala Thr Arg Val Leu Val Phe Asp His 
            180                 185                 190         


His Arg Gln Val Asp Ala His Arg Ala Ala Val Glu Ser Ala Arg Glu 
        195                 200                 205             


Arg Leu Ala Gly Ser Ala Val Val Glu Thr Leu Ala Glu Ala Ile Ala 
    210                 215                 220                 


Arg Gly Asp Val Pro Arg Gly Ala Ser Ala Gly Ser Ala Pro Gly Thr 
225                 230                 235                 240 


Asp Val Ser Asp Asp Ser Leu Ala Leu Leu Ile Tyr Thr Ser Gly Ser 
                245                 250                 255     


Thr Gly Ala Pro Lys Gly Ala Met Tyr Pro Arg Arg Asn Val Ala Thr 
            260                 265                 270         


Phe Trp Arg Lys Arg Thr Trp Phe Glu Gly Gly Tyr Glu Pro Ser Ile 
        275                 280                 285             


Thr Leu Asn Phe Met Pro Met Ser His Val Met Gly Arg Gln Ile Leu 
    290                 295                 300                 


Tyr Gly Thr Leu Cys Asn Gly Gly Thr Ala Tyr Phe Val Ala Lys Ser 
305                 310                 315                 320 


Asp Leu Ser Thr Leu Phe Glu Asp Leu Ala Leu Val Arg Pro Thr Glu 
                325                 330                 335     


Leu Thr Phe Val Pro Arg Val Trp Asp Met Val Phe Asp Glu Phe Gln 
            340                 345                 350         


Ser Glu Val Asp Arg Arg Leu Val Asp Gly Ala Asp Arg Val Ala Leu 
        355                 360                 365             


Glu Ala Gln Val Lys Ala Glu Ile Arg Asn Asp Val Leu Gly Gly Arg 
    370                 375                 380                 


Tyr Thr Ser Ala Leu Thr Gly Ser Ala Pro Ile Ser Asp Glu Met Lys 
385                 390                 395                 400 


Ala Trp Val Glu Glu Leu Leu Asp Met His Leu Val Glu Gly Tyr Gly 
                405                 410                 415     


Ser Thr Glu Ala Gly Met Ile Leu Ile Asp Gly Ala Ile Arg Arg Pro 
            420                 425                 430         


Ala Val Leu Asp Tyr Lys Leu Val Asp Val Pro Asp Leu Gly Tyr Phe 
        435                 440                 445             


Leu Thr Asp Arg Pro His Pro Arg Gly Glu Leu Leu Val Lys Thr Asp 
    450                 455                 460                 


Ser Leu Phe Pro Gly Tyr Tyr Gln Arg Ala Glu Val Thr Ala Asp Val 
465                 470                 475                 480 


Phe Asp Ala Asp Gly Phe Tyr Arg Thr Gly Asp Ile Met Ala Glu Val 
                485                 490                 495     


Gly Pro Glu Gln Phe Val Tyr Leu Asp Arg Arg Asn Asn Val Leu Lys 
            500                 505                 510         


Leu Ser Gln Gly Glu Phe Val Thr Val Ser Lys Leu Glu Ala Val Phe 
        515                 520                 525             


Gly Asp Ser Pro Leu Val Arg Gln Ile Tyr Ile Tyr Gly Asn Ser Ala 
    530                 535                 540                 


Arg Ala Tyr Leu Leu Ala Val Ile Val Pro Thr Gln Glu Ala Leu Asp 
545                 550                 555                 560 


Ala Val Pro Val Glu Glu Leu Lys Ala Arg Leu Gly Asp Ser Leu Gln 
                565                 570                 575     


Glu Val Ala Lys Ala Ala Gly Leu Gln Ser Tyr Glu Ile Pro Arg Asp 
            580                 585                 590         


Phe Ile Ile Glu Thr Thr Pro Trp Thr Leu Glu Asn Gly Leu Leu Thr 
        595                 600                 605             


Gly Ile Arg Lys Leu Ala Arg Pro Gln Leu Lys Lys His Tyr Gly Glu 
    610                 615                 620                 


Leu Leu Glu Gln Ile Tyr Thr Asp Leu Ala His Gly Gln Ala Asp Glu 
625                 630                 635                 640 


Leu Arg Ser Leu Arg Gln Ser Gly Ala Asp Ala Pro Val Leu Val Thr 
                645                 650                 655     


Val Cys Arg Ala Ala Ala Ala Leu Leu Gly Gly Ser Ala Ser Asp Val 
            660                 665                 670         


Gln Pro Asp Ala His Phe Thr Asp Leu Gly Gly Asp Ser Leu Ser Ala 
        675                 680                 685             


Leu Ser Phe Thr Asn Leu Leu His Glu Ile Phe Asp Ile Glu Val Pro 
    690                 695                 700                 


Val Gly Val Ile Val Ser Pro Ala Asn Asp Leu Gln Ala Leu Ala Asp 
705                 710                 715                 720 


Tyr Val Glu Ala Ala Arg Lys Pro Gly Ser Ser Arg Pro Thr Phe Ala 
                725                 730                 735     


Ser Val His Gly Ala Ser Asn Gly Gln Val Thr Glu Val His Ala Gly 
            740                 745                 750         


Asp Leu Ser Leu Asp Lys Phe Ile Asp Ala Ala Thr Leu Ala Glu Ala 
        755                 760                 765             


Pro Arg Leu Pro Ala Ala Asn Thr Gln Val Arg Thr Val Leu Leu Thr 
    770                 775                 780                 


Gly Ala Thr Gly Phe Leu Gly Arg Tyr Leu Ala Leu Glu Trp Leu Glu 
785                 790                 795                 800 


Arg Met Asp Leu Val Asp Gly Lys Leu Ile Cys Leu Val Arg Ala Lys 
                805                 810                 815     


Ser Asp Thr Glu Ala Arg Ala Arg Leu Asp Lys Thr Phe Asp Ser Gly 
            820                 825                 830         


Asp Pro Glu Leu Leu Ala His Tyr Arg Ala Leu Ala Gly Asp His Leu 
        835                 840                 845             


Glu Val Leu Ala Gly Asp Lys Gly Glu Ala Asp Leu Gly Leu Asp Arg 
    850                 855                 860                 


Gln Thr Trp Gln Arg Leu Ala Asp Thr Val Asp Leu Ile Val Asp Pro 
865                 870                 875                 880 


Ala Ala Leu Val Asn His Val Leu Pro Tyr Ser Gln Leu Phe Gly Pro 
                885                 890                 895     


Asn Ala Leu Gly Thr Ala Glu Leu Leu Arg Leu Ala Leu Thr Ser Lys 
            900                 905                 910         


Ile Lys Pro Tyr Ser Tyr Thr Ser Thr Ile Gly Val Ala Asp Gln Ile 
        915                 920                 925             


Pro Pro Ser Ala Phe Thr Glu Asp Ala Asp Ile Arg Val Ile Ser Ala 
    930                 935                 940                 


Thr Arg Ala Val Asp Asp Ser Tyr Ala Asn Gly Tyr Ser Asn Ser Lys 
945                 950                 955                 960 


Trp Ala Gly Glu Val Leu Leu Arg Glu Ala His Asp Leu Cys Gly Leu 
                965                 970                 975     


Pro Val Ala Val Phe Arg Cys Asp Met Ile Leu Ala Asp Thr Thr Trp 
            980                 985                 990         


Ala Gly Gln Leu Asn Val Pro Asp  Met Phe Thr Arg Met  Ile Leu Ser 
        995                 1000                 1005             


Leu Ala  Ala Thr Gly Ile Ala  Pro Gly Ser Phe Tyr  Glu Leu Ala 
    1010                 1015                 1020             


Ala Asp  Gly Ala Arg Gln Arg  Ala His Tyr Asp Gly  Leu Pro Val 
    1025                 1030                 1035             


Glu Phe  Ile Ala Glu Ala Ile  Ser Thr Leu Gly Ala  Gln Ser Gln 
    1040                 1045                 1050             


Asp Gly  Phe His Thr Tyr His  Val Met Asn Pro Tyr  Asp Asp Gly 
    1055                 1060                 1065             


Ile Gly  Leu Asp Glu Phe Val  Asp Trp Leu Asn Glu  Ser Gly Cys 
    1070                 1075                 1080             


Pro Ile  Gln Arg Ile Ala Asp  Tyr Gly Asp Trp Leu  Gln Arg Phe 
    1085                 1090                 1095             


Glu Thr  Ala Leu Arg Ala Leu  Pro Asp Arg Gln Arg  His Ser Ser 
    1100                 1105                 1110             


Leu Leu  Pro Leu Leu His Asn  Tyr Arg Gln Pro Glu  Arg Pro Val 
    1115                 1120                 1125             


Arg Gly  Ser Ile Ala Pro Thr  Asp Arg Phe Arg Ala  Ala Val Gln 
    1130                 1135                 1140             


Glu Ala  Lys Ile Gly Pro Asp  Lys Asp Ile Pro His  Val Gly Ala 
    1145                 1150                 1155             


Pro Ile  Ile Val Lys Tyr Val  Ser Asp Leu Arg Leu  Leu Gly Leu 
    1160                 1165                 1170             


Leu 
    


<210> 11
<211> 3522
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      carboxylic acid reductase polynucleotide 
      designated 891GA

<400> 11
atgagcaccg caacccatga tgaacgtctg gatcgtcgtg ttcatgaact gattgcaacc       60

gatccgcagt ttgcagcagc acagccggat cctgcaatta ccgcagcact ggaacagcct      120

ggtctgcgtc tgccgcagat tattcgtacc gttctggatg gttatgcaga tcgtccggca      180

ctgggtcagc gtgttgttga atttgttacc gatgcaaaaa ccggtcgtac cagcgcacag      240

ctgctgcctc gttttgaaac cattacctat agcgaagttg cacagcgtgt tagcgcactg      300

ggtcgtgcac tgagtgatga tgcagttcat ccgggtgatc gtgtttgtgt tctgggtttt      360

aatagcgttg attatgccac cattgatatg gcactgggtg caattggtgc agttagcgtt      420

ccgctgcaga ccagcgcagc aattagcagc ctgcagccga ttgttgcaga aaccgaaccg      480

accctgattg caagcagcgt taatcagctg tcagatgcag ttcagctgat taccggtgca      540

gaacaggcac cgacccgtct ggttgttttt gattatcatc cgcaggttga tgatcagcgt      600

gaagcagttc aggatgcagc agcacgtctg agcagcaccg gtgttgcagt tcagaccctg      660

gcagaactgc tggaacgtgg taaagatctg cctgcagttg cagaaccgcc tgcagatgaa      720

gatagcctgg cactgctgat ttataccagc ggtagcacag gtgcaccgaa aggtgcaatg      780

tatccgcaga gcaatgttgg taaaatgtgg cgtcgtggta gcaaaaattg gtttggtgaa      840

agcgcagcaa gcattaccct gaatttcatg ccgatgagcc atgttatggg tcgtagcatt      900

ctgtatggca ccctgggtaa tggtggcacc gcatattttg cagcacgtag cgatctgagc      960

accctgctgg aagatctgga actggttcgt ccgaccgaac tgaattttgt tccgcgtatt     1020

tgggaaaccc tgtatggtga atttcagcgt caggttgaac gtcgtctgag cgaagctggc     1080

gatgccggtg aacgtcgtgc agttgaagca gaagttctgg cagaacagcg tcagtatctg     1140

ctgggtggtc gttttacctt tgcaatgacc ggtagcgcac cgattagtcc ggaactgcgt     1200

aattgggttg aaagcctgct ggaaatgcat ctgatggatg gctatggtag caccgaagca     1260

ggtatggttc tgtttgatgg cgaaattcag cgtccgcctg tgattgatta taaactggtt     1320

gatgttccgg atctgggtta ttttagcacc gatcgtccgc atccgcgtgg tgaactgctg     1380

ctgcgtaccg aaaatatgtt tccgggttat tataaacgtg cagaaaccac cgcaggcgtt     1440

tttgatgaag atggttatta tcgtaccggt gatgtgtttg cagaaattgc accggatcgt     1500

ctggtttatg ttgatcgtcg taataatgtt ctgaaactgg cacagggtga atttgtgacc     1560

ctggccaaac tggaagcagt ttttggtaat agtccgctga ttcgtcagat ttatgtgtat     1620

ggtaatagcg cacagccgta tctgctggca gttgttgttc cgaccgaaga ggcactggca     1680

agcggtgatc cggaaaccct gaaaccgaaa attgcagata gcctgcagca ggttgcaaaa     1740

gaagcaggtc tgcagagcta tgaagttccg cgtgatttta ttattgaaac caccccgttt     1800

agcctggaaa atggtctgct gaccggtatt cgtaaactgg catggccgaa actgaaacag     1860

cattatggtg aacgcctgga acaaatgtat gcagatctgg cagcaggtca ggcaaatgaa     1920

ctggccgaac tgcgtcgtaa tggtgcacag gcaccggttc tgcagaccgt tagccgtgca     1980

gccggtgcaa tgctgggtag cgcagccagc gatctgagtc cggatgcaca ttttaccgat     2040

ctgggtggtg atagcctgag cgcactgacc tttggtaatc tgctgcgtga aatttttgat     2100

gttgatgtgc cggttggtgt tattgttagt ccggctaatg atctggcagc cattgcaagc     2160

tatattgaag cagaacgtca gggtagcaaa cgtccgacct ttgcaagcgt tcatggtcgt     2220

gatgcaaccg ttgttcgtgc agcagatctg accctggata aatttctgga tgcagaaacc     2280

ctggcagcag caccgaatct gccgaaaccg gcaaccgaag ttcgtaccgt gctgctgaca     2340

ggtgcaaccg gttttctggg tcgttatctg gcactggaat ggctggaacg tatggatatg     2400

gttgatggta aagttattgc actggttcgt gcccgtagtg atgaagaagc acgcgcacgt     2460

ctggataaaa cctttgatag tggtgatccg aaactgctgg cacattatca gcagctggct     2520

gcagatcatc tggaagttat tgccggtgat aaaggtgaag caaatctggg tctgggtcag     2580

gatgtttggc agcgtctggc agataccgtt gatgttattg tggatccggc agcactggtt     2640

aatcatgttc tgccgtatag cgaactgttt ggtccgaatg cactgggcac cgcagaactg     2700

attcgtctgg cactgaccag caaacagaaa ccgtatacct atgttagcac cattggtgtt     2760

ggcgatcaga ttgaaccggg taaatttgtt gaaaatgccg atattcgtca gatgagcgca     2820

acccgtgcaa ttaatgatag ctatgcaaat ggctacggca atagcaaatg ggcaggcgaa     2880

gttctgctgc gcgaagcaca tgatctgtgt ggtctgccgg ttgcagtttt tcgttgtgat     2940

atgattctgg ccgataccac ctatgcaggt cagctgaatc tgccggatat gtttacccgt     3000

ctgatgctga gcctggttgc aaccggtatt gcaccgggta gcttttatga actggatgca     3060

gatggtaatc gtcagcgtgc acattatgat ggcctgccgg ttgaatttat tgcagcagcc     3120

attagcaccc tgggttcaca gattaccgat agcgataccg gttttcagac ctatcatgtt     3180

atgaacccgt atgatgatgg tgttggtctg gatgaatatg ttgattggct ggttgatgcc     3240

ggttatagca ttgaacgtat tgcagattat agcgaatggc tgcgtcgctt tgaaacctca     3300

ctgcgtgcac tgccggatcg tcagcgccag tatagcctgc tgccgctgct gcacaattat     3360

cgtacaccgg aaaaaccgat taatggtagc attgcaccga ccgatgtttt tcgtgcagcc     3420

gttcaagaag ccaaaattgg tccggataaa gatattccgc atgttagccc tccggtgatt     3480

gttaaatata ttaccgatct gcagctgctg ggtctgctgt aa                        3522


<210> 12
<211> 1173
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      carboxylic acid reductase polypeptide 
      designated 891GA

<400> 12
Met Ser Thr Ala Thr His Asp Glu Arg Leu Asp Arg Arg Val His Glu 
1               5                   10                  15      


Leu Ile Ala Thr Asp Pro Gln Phe Ala Ala Ala Gln Pro Asp Pro Ala 
            20                  25                  30          


Ile Thr Ala Ala Leu Glu Gln Pro Gly Leu Arg Leu Pro Gln Ile Ile 
        35                  40                  45              


Arg Thr Val Leu Asp Gly Tyr Ala Asp Arg Pro Ala Leu Gly Gln Arg 
    50                  55                  60                  


Val Val Glu Phe Val Thr Asp Ala Lys Thr Gly Arg Thr Ser Ala Gln 
65                  70                  75                  80  


Leu Leu Pro Arg Phe Glu Thr Ile Thr Tyr Ser Glu Val Ala Gln Arg 
                85                  90                  95      


Val Ser Ala Leu Gly Arg Ala Leu Ser Asp Asp Ala Val His Pro Gly 
            100                 105                 110         


Asp Arg Val Cys Val Leu Gly Phe Asn Ser Val Asp Tyr Ala Thr Ile 
        115                 120                 125             


Asp Met Ala Leu Gly Ala Ile Gly Ala Val Ser Val Pro Leu Gln Thr 
    130                 135                 140                 


Ser Ala Ala Ile Ser Ser Leu Gln Pro Ile Val Ala Glu Thr Glu Pro 
145                 150                 155                 160 


Thr Leu Ile Ala Ser Ser Val Asn Gln Leu Ser Asp Ala Val Gln Leu 
                165                 170                 175     


Ile Thr Gly Ala Glu Gln Ala Pro Thr Arg Leu Val Val Phe Asp Tyr 
            180                 185                 190         


His Pro Gln Val Asp Asp Gln Arg Glu Ala Val Gln Asp Ala Ala Ala 
        195                 200                 205             


Arg Leu Ser Ser Thr Gly Val Ala Val Gln Thr Leu Ala Glu Leu Leu 
    210                 215                 220                 


Glu Arg Gly Lys Asp Leu Pro Ala Val Ala Glu Pro Pro Ala Asp Glu 
225                 230                 235                 240 


Asp Ser Leu Ala Leu Leu Ile Tyr Thr Ser Gly Ser Thr Gly Ala Pro 
                245                 250                 255     


Lys Gly Ala Met Tyr Pro Gln Ser Asn Val Gly Lys Met Trp Arg Arg 
            260                 265                 270         


Gly Ser Lys Asn Trp Phe Gly Glu Ser Ala Ala Ser Ile Thr Leu Asn 
        275                 280                 285             


Phe Met Pro Met Ser His Val Met Gly Arg Ser Ile Leu Tyr Gly Thr 
    290                 295                 300                 


Leu Gly Asn Gly Gly Thr Ala Tyr Phe Ala Ala Arg Ser Asp Leu Ser 
305                 310                 315                 320 


Thr Leu Leu Glu Asp Leu Glu Leu Val Arg Pro Thr Glu Leu Asn Phe 
                325                 330                 335     


Val Pro Arg Ile Trp Glu Thr Leu Tyr Gly Glu Phe Gln Arg Gln Val 
            340                 345                 350         


Glu Arg Arg Leu Ser Glu Ala Gly Asp Ala Gly Glu Arg Arg Ala Val 
        355                 360                 365             


Glu Ala Glu Val Leu Ala Glu Gln Arg Gln Tyr Leu Leu Gly Gly Arg 
    370                 375                 380                 


Phe Thr Phe Ala Met Thr Gly Ser Ala Pro Ile Ser Pro Glu Leu Arg 
385                 390                 395                 400 


Asn Trp Val Glu Ser Leu Leu Glu Met His Leu Met Asp Gly Tyr Gly 
                405                 410                 415     


Ser Thr Glu Ala Gly Met Val Leu Phe Asp Gly Glu Ile Gln Arg Pro 
            420                 425                 430         


Pro Val Ile Asp Tyr Lys Leu Val Asp Val Pro Asp Leu Gly Tyr Phe 
        435                 440                 445             


Ser Thr Asp Arg Pro His Pro Arg Gly Glu Leu Leu Leu Arg Thr Glu 
    450                 455                 460                 


Asn Met Phe Pro Gly Tyr Tyr Lys Arg Ala Glu Thr Thr Ala Gly Val 
465                 470                 475                 480 


Phe Asp Glu Asp Gly Tyr Tyr Arg Thr Gly Asp Val Phe Ala Glu Ile 
                485                 490                 495     


Ala Pro Asp Arg Leu Val Tyr Val Asp Arg Arg Asn Asn Val Leu Lys 
            500                 505                 510         


Leu Ala Gln Gly Glu Phe Val Thr Leu Ala Lys Leu Glu Ala Val Phe 
        515                 520                 525             


Gly Asn Ser Pro Leu Ile Arg Gln Ile Tyr Val Tyr Gly Asn Ser Ala 
    530                 535                 540                 


Gln Pro Tyr Leu Leu Ala Val Val Val Pro Thr Glu Glu Ala Leu Ala 
545                 550                 555                 560 


Ser Gly Asp Pro Glu Thr Leu Lys Pro Lys Ile Ala Asp Ser Leu Gln 
                565                 570                 575     


Gln Val Ala Lys Glu Ala Gly Leu Gln Ser Tyr Glu Val Pro Arg Asp 
            580                 585                 590         


Phe Ile Ile Glu Thr Thr Pro Phe Ser Leu Glu Asn Gly Leu Leu Thr 
        595                 600                 605             


Gly Ile Arg Lys Leu Ala Trp Pro Lys Leu Lys Gln His Tyr Gly Glu 
    610                 615                 620                 


Arg Leu Glu Gln Met Tyr Ala Asp Leu Ala Ala Gly Gln Ala Asn Glu 
625                 630                 635                 640 


Leu Ala Glu Leu Arg Arg Asn Gly Ala Gln Ala Pro Val Leu Gln Thr 
                645                 650                 655     


Val Ser Arg Ala Ala Gly Ala Met Leu Gly Ser Ala Ala Ser Asp Leu 
            660                 665                 670         


Ser Pro Asp Ala His Phe Thr Asp Leu Gly Gly Asp Ser Leu Ser Ala 
        675                 680                 685             


Leu Thr Phe Gly Asn Leu Leu Arg Glu Ile Phe Asp Val Asp Val Pro 
    690                 695                 700                 


Val Gly Val Ile Val Ser Pro Ala Asn Asp Leu Ala Ala Ile Ala Ser 
705                 710                 715                 720 


Tyr Ile Glu Ala Glu Arg Gln Gly Ser Lys Arg Pro Thr Phe Ala Ser 
                725                 730                 735     


Val His Gly Arg Asp Ala Thr Val Val Arg Ala Ala Asp Leu Thr Leu 
            740                 745                 750         


Asp Lys Phe Leu Asp Ala Glu Thr Leu Ala Ala Ala Pro Asn Leu Pro 
        755                 760                 765             


Lys Pro Ala Thr Glu Val Arg Thr Val Leu Leu Thr Gly Ala Thr Gly 
    770                 775                 780                 


Phe Leu Gly Arg Tyr Leu Ala Leu Glu Trp Leu Glu Arg Met Asp Met 
785                 790                 795                 800 


Val Asp Gly Lys Val Ile Ala Leu Val Arg Ala Arg Ser Asp Glu Glu 
                805                 810                 815     


Ala Arg Ala Arg Leu Asp Lys Thr Phe Asp Ser Gly Asp Pro Lys Leu 
            820                 825                 830         


Leu Ala His Tyr Gln Gln Leu Ala Ala Asp His Leu Glu Val Ile Ala 
        835                 840                 845             


Gly Asp Lys Gly Glu Ala Asn Leu Gly Leu Gly Gln Asp Val Trp Gln 
    850                 855                 860                 


Arg Leu Ala Asp Thr Val Asp Val Ile Val Asp Pro Ala Ala Leu Val 
865                 870                 875                 880 


Asn His Val Leu Pro Tyr Ser Glu Leu Phe Gly Pro Asn Ala Leu Gly 
                885                 890                 895     


Thr Ala Glu Leu Ile Arg Leu Ala Leu Thr Ser Lys Gln Lys Pro Tyr 
            900                 905                 910         


Thr Tyr Val Ser Thr Ile Gly Val Gly Asp Gln Ile Glu Pro Gly Lys 
        915                 920                 925             


Phe Val Glu Asn Ala Asp Ile Arg Gln Met Ser Ala Thr Arg Ala Ile 
    930                 935                 940                 


Asn Asp Ser Tyr Ala Asn Gly Tyr Gly Asn Ser Lys Trp Ala Gly Glu 
945                 950                 955                 960 


Val Leu Leu Arg Glu Ala His Asp Leu Cys Gly Leu Pro Val Ala Val 
                965                 970                 975     


Phe Arg Cys Asp Met Ile Leu Ala Asp Thr Thr Tyr Ala Gly Gln Leu 
            980                 985                 990         


Asn Leu Pro Asp Met Phe Thr Arg  Leu Met Leu Ser Leu  Val Ala Thr 
        995                 1000                 1005             


Gly Ile  Ala Pro Gly Ser Phe  Tyr Glu Leu Asp Ala  Asp Gly Asn 
    1010                 1015                 1020             


Arg Gln  Arg Ala His Tyr Asp  Gly Leu Pro Val Glu  Phe Ile Ala 
    1025                 1030                 1035             


Ala Ala  Ile Ser Thr Leu Gly  Ser Gln Ile Thr Asp  Ser Asp Thr 
    1040                 1045                 1050             


Gly Phe  Gln Thr Tyr His Val  Met Asn Pro Tyr Asp  Asp Gly Val 
    1055                 1060                 1065             


Gly Leu  Asp Glu Tyr Val Asp  Trp Leu Val Asp Ala  Gly Tyr Ser 
    1070                 1075                 1080             


Ile Glu  Arg Ile Ala Asp Tyr  Ser Glu Trp Leu Arg  Arg Phe Glu 
    1085                 1090                 1095             


Thr Ser  Leu Arg Ala Leu Pro  Asp Arg Gln Arg Gln  Tyr Ser Leu 
    1100                 1105                 1110             


Leu Pro  Leu Leu His Asn Tyr  Arg Thr Pro Glu Lys  Pro Ile Asn 
    1115                 1120                 1125             


Gly Ser  Ile Ala Pro Thr Asp  Val Phe Arg Ala Ala  Val Gln Glu 
    1130                 1135                 1140             


Ala Lys  Ile Gly Pro Asp Lys  Asp Ile Pro His Val  Ser Pro Pro 
    1145                 1150                 1155             


Val Ile  Val Lys Tyr Ile Thr  Asp Leu Gln Leu Leu  Gly Leu Leu 
    1160                 1165                 1170             


