                         SEQUENCE LISTING

<110>  UNIVERSITE DE GENEVE
 
<120>  New uses of NANOG inhibitors and related methods

<130>  P1335US00

<150>  US 61/500,809
<151>  2011-06-24

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  2
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Asn Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  3
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
                165                 170                 175     


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
            180                 185                 190         


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
        195                 200                 205             


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
    210                 215                 220                 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
225                 230                 235                 240 


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
                245                 250                 255     


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
            260                 265                 270         


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
        275                 280                 285             


Val 
    


<210>  4
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Asn Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met His Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  5
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Gln Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu 
1               5                   10                  15      


Asn Asp Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln 
            20                  25                  30          


Glu Leu Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp 
        35                  40                  45              


Phe Gln Asn Gln Arg Met Lys Ser Lys Arg Trp Gln 
    50                  55                  60  


<210>  6
<211>  305
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ser Val Gly Leu Pro Gly Pro His Ser Leu Pro Ser Ser Glu Glu 
1               5                   10                  15      


Ala Ser Asn Ser Gly Asn Ala Ser Ser Met Pro Ala Val Phe His Pro 
            20                  25                  30          


Glu Asn Tyr Ser Cys Leu Gln Gly Ser Ala Thr Glu Met Leu Cys Thr 
        35                  40                  45              


Glu Ala Ala Ser Pro Arg Pro Ser Ser Glu Asp Leu Pro Leu Gln Gly 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gln Lys Leu Ser Ser Pro Glu 
65                  70                  75                  80  


Ala Asp Lys Gly Pro Glu Glu Glu Glu Asn Lys Val Leu Ala Arg Lys 
                85                  90                  95      


Gln Lys Met Arg Thr Val Phe Ser Gln Ala Gln Leu Cys Ala Leu Lys 
            100                 105                 110         


Asp Arg Phe Gln Lys Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu 
        115                 120                 125             


Leu Ser Ser Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe 
    130                 135                 140                 


Gln Asn Gln Arg Met Lys Cys Lys Arg Trp Gln Lys Asn Gln Trp Leu 
145                 150                 155                 160 


Lys Thr Ser Asn Gly Leu Ile Gln Lys Gly Ser Ala Pro Val Glu Tyr 
                165                 170                 175     


Pro Ser Ile His Cys Ser Tyr Pro Gln Gly Tyr Leu Val Asn Ala Ser 
            180                 185                 190         


Gly Ser Leu Ser Met Trp Gly Ser Gln Thr Trp Thr Asn Pro Thr Trp 
        195                 200                 205             


Ser Ser Gln Thr Trp Thr Asn Pro Thr Trp Asn Asn Gln Thr Trp Thr 
    210                 215                 220                 


Asn Pro Thr Trp Ser Ser Gln Ala Trp Thr Ala Gln Ser Trp Asn Gly 
225                 230                 235                 240 


Gln Pro Trp Asn Ala Ala Pro Leu His Asn Phe Gly Glu Asp Phe Leu 
                245                 250                 255     


Gln Pro Tyr Val Gln Leu Gln Gln Asn Phe Ser Ala Ser Asp Leu Glu 
            260                 265                 270         


Val Asn Leu Glu Ala Thr Arg Glu Ser His Ala His Phe Ser Thr Pro 
        275                 280                 285             


Gln Ala Leu Glu Leu Phe Leu Asn Tyr Ser Val Thr Pro Pro Gly Glu 
    290                 295                 300                 


Ile 
305 


<210>  7
<211>  300
<212>  PRT
<213>  Bos taurus

<400>  7

Met Ser Val Gly Pro Ala Cys Pro Gln Ser Leu Leu Gly Pro Glu Ala 
1               5                   10                  15      


Ser Asn Ser Arg Glu Ser Ser Pro Met Pro Glu Glu Ser Tyr Val Ser 
            20                  25                  30          


Leu Gln Thr Ser Ser Ala Asp Thr Leu Asp Thr Asp Thr Val Ser Pro 
        35                  40                  45              


Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp Ser Pro Asp Ser Ser 
    50                  55                  60                  


Thr Ser Pro Arg Val Lys Pro Leu Ser Pro Ser Val Glu Glu Ser Thr 
65                  70                  75                  80  


Glu Lys Glu Glu Thr Val Pro Val Lys Lys Gln Lys Ile Arg Thr Val 
                85                  90                  95      


Phe Ser Gln Thr Gln Leu Cys Val Leu Asn Asp Arg Phe Gln Arg Gln 
            100                 105                 110         


Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu Ser Asn Ile Leu Asn 
        115                 120                 125             


Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln Asn Gln Arg Met Lys 
    130                 135                 140                 


Cys Lys Lys Trp Gln Lys Asn Asn Trp Pro Arg Asn Ser Asn Gly Met 
145                 150                 155                 160 


Pro Gln Gly Pro Ala Met Ala Glu Tyr Pro Gly Phe Tyr Ser Tyr His 
                165                 170                 175     


Gln Gly Cys Leu Val Asn Ser Pro Gly Asn Leu Pro Met Trp Gly Asn 
            180                 185                 190         


Gln Thr Trp Asn Asn Pro Thr Trp Ser Asn Gln Ser Trp Asn Ser Gln 
        195                 200                 205             


Ser Trp Ser Asn His Ser Trp Asn Ser Gln Ala Trp Cys Pro Gln Ala 
    210                 215                 220                 


Trp Asn Asn Gln Pro Trp Asn Asn Gln Phe Asn Asn Tyr Met Glu Glu 
225                 230                 235                 240 


Phe Leu Gln Pro Gly Ile Gln Leu Gln Gln Asn Ser Pro Val Cys Asp 
                245                 250                 255     


Leu Glu Ala Thr Leu Gly Thr Ala Gly Glu Asn Tyr Asn Val Ile Gln 
            260                 265                 270         


Gln Thr Val Lys Tyr Phe Asn Ser Gln Gln Gln Ile Thr Asp Leu Phe 
        275                 280                 285             


Pro Asn Tyr Pro Leu Asn Ile Gln Pro Glu Asp Leu 
    290                 295                 300 


<210>  8
<211>  311
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Ser Val Asp Leu Ser Gly Pro His Ser Leu Pro Ser Cys Glu Glu 
1               5                   10                  15      


Ala Ser Asn Ser Gly Asp Ser Ser Pro Met Pro Ala Val His Leu Pro 
            20                  25                  30          


Glu Glu Asn Tyr Ser Cys Leu Gln Val Ser Ala Thr Glu Met Leu Cys 
        35                  40                  45              


Thr Glu Thr Ala Ser Pro Pro Pro Ser Ser Gly Asp Leu Pro Leu Gln 
    50                  55                  60                  


Asp Ser Pro Asp Ser Ser Ser Asn Pro Lys Leu Lys Leu Ser Gly Pro 
65                  70                  75                  80  


Arg Leu Thr Arg Ala Leu Arg Arg Lys Lys Arg Thr Arg Ser Ser Pro 
                85                  90                  95      


Arg Lys Gln Lys Met Arg Thr Val Phe Ser Gln Ala Gln Leu Cys Ala 
            100                 105                 110         


Leu Lys Asp Arg Phe Gln Arg Gln Arg Tyr Leu Ser Leu Gln Gln Met 
        115                 120                 125             


Gln Asp Leu Ser Thr Ile Leu Ser Leu Ser Tyr Lys Gln Val Lys Thr 
    130                 135                 140                 


Trp Phe Gln Asn Gln Arg Met Lys Cys Lys Arg Trp Gln Lys Asn Gln 
145                 150                 155                 160 


Trp Leu Lys Thr Ser Asn Gly Leu Thr Gln Gly Ser Ala Pro Val Glu 
                165                 170                 175     


Tyr Pro Ser Ile His Cys Ser Tyr Ser Gln Gly Tyr Leu Met Asn Ala 
            180                 185                 190         


Ser Gly Asn Leu Pro Val Trp Gly Ser Gln Thr Trp Thr Asn Pro Thr 
        195                 200                 205             


Trp Asn Asn Gln Thr Trp Thr Asn Pro Thr Trp Ser Asn Gln Thr Trp 
    210                 215                 220                 


Thr Asn Pro Thr Trp Ser Asn Gln Ala Trp Ser Thr Gln Ser Trp Cys 
225                 230                 235                 240 


Thr Gln Ala Cys Asn Ser Gln Thr Trp Asn Ala Ala Pro Leu His Asn 
                245                 250                 255     


Phe Gly Glu Asp Ser Leu Gln Pro Tyr Val Pro Leu Gln Gln Asn Phe 
            260                 265                 270         


Ser Ala Ser Asp Leu Glu Ala Asn Leu Glu Ala Thr Arg Glu Ser Gln 
        275                 280                 285             


Ala His Phe Ser Thr Pro Gln Ala Leu Glu Leu Phe Leu Asn Tyr Ser 
    290                 295                 300                 


Val Asn Ser Pro Gly Glu Ile 
305                 310     


<210>  9
<211>  918
<212>  DNA
<213>  Homo sapiens

<400>  9
atgagtgtgg atccagcttg tccccaaagc ttgccttgct ttgaagcatc cgactgtaaa       60

gaatcttcac ctatgcctgt gatttgtggg cctgaagaaa actatccatc cttgcaaatg      120

tcttctgctg agatgcctca cacggagact gtctctcctc ttccttcctc catggatctg      180

cttattcagg acagccctga ttcttccacc agtcccaaag gcaaacaacc cacttctgca      240

gagaagagtg tcgcaaaaaa ggaagacaag gtcccggtca agaaacagaa gaccagaact      300

gtgttctctt ccacccagct gtgtgtactc aatgatagat ttcagagaca gaaatacctc      360

agcctccagc agatgcaaga actctccaac atcctgaacc tcagctacaa acaggtgaag      420

acctggttcc agaaccagag aatgaaatct aagaggtggc agaaaaacaa ctggccgaag      480

aatagcaatg gtgtgacgca gaaggcctca gcacctacct accccagcct ttactcttcc      540

taccaccagg gatgcctggt gaacccgact gggaaccttc caatgtggag caaccagacc      600

tggaacaatt caacctggag caaccagacc cagaacatcc agtcctggag caaccactcc      660

tggaacactc agacctggtg cacccaatcc tggaacaatc aggcctggaa cagtcccttc      720

tataactgtg gagaggaatc tctgcagtcc tgcatgcagt tccagccaaa ttctcctgcc      780

agtgacttgg aggctgcctt ggaagctgct ggggaaggcc ttaatgtaat acagcagacc      840

actaggtatt ttagtactcc acaaaccatg gatttattcc taaactactc catgaacatg      900

caacctgaag acgtgtga                                                    918


<210>  10
<211>  918
<212>  DNA
<213>  Homo sapiens

<400>  10
atgagtgtgg atccagcttg tccccaaagc ttgccttgct ttgaagaatc cgactgtaaa       60

gaatcttcac ctatgcctgt gatttgtggg cctgaagaaa actatccatc cttgcaaatg      120

tcttctgctg agatgcctca cacagagact gtctctcctc ttccttcctc catggatctg      180

cttattcagg acagccctga ttcttccacc agtcccaaag gcaaacaacc cacttctgca      240

gagaatagtg tcgcaaaaaa ggaagacaag gtcccggtca agaaacagaa gaccagaact      300

gtgttctctt ccacccagct gtgtgtactc aatgatagat ttcagagaca gaaatacctc      360

agcctccagc agatgcaaga actctccaac atcctgaacc tcagctacaa acaggtgaag      420

acctggttcc agaaccagag aatgaaatct aagaggtggc agaaaaacaa ctggccgaag      480

aatagcaatg gtgtgacgca gaaggcctca gcacctacct accccagcct ctactcttcc      540

taccaccagg gatgcctggt gaacccgact gggaaccttc caatgtggag caaccagacc      600

tggaacaatt caacctggag caaccagacc cagaacatcc agtcctggag caaccactcc      660

tggaacactc agacctggtg cacccaatcc tggaacaatc aggcctggaa cagtcccttc      720

tataactgtg gagaggaatc tctgcagtcc tgcatgcact tccagccaaa ttctcctgcc      780

agtgacttgg aggctgcctt ggaagctgct ggggaaggcc ttaatgtaat acagcagacc      840

actaggtatt ttagtactcc acaaaccatg gatttattcc taaactactc catgaacatg      900

caacctgaag acgtgtga                                                    918


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shNANOG1

<400>  11
gggttagctg taacatactt                                                   20


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shNANOG2

<400>  12
cctggaacag tcccttctat a                                                 21


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shNANOGP8

<400>  13
aacaaagcac atcttgccag ga                                                22


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOG and NANOGP8 forward primer

<400>  14
aaattggtga tgaagatgta ttcg                                              24


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOG and NANOGP8 reverse primer

<400>  15
gcaaaacaga gccaaaaacg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOGP8 forward primer

<400>  16
gctgccttca agcatctgtt                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOGP8 reverse primer

<400>  17
ttgtttgcct ttgggactgg t                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOG and NANOGP8 3'UTR forward primer

<400>  18
ggatggtctc gatctcctga                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NANOG and NANOGP8 3'UTR reverse primer

<400>  19
cccaatccca aacaatacga                                                   20


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta ACTIN forward primer

<400>  20
tggagaaaat ctggcaccac acc                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta ACTIN reverse primer

<400>  21
gatgggcaca gtgtgggtga ccc                                               23


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP forward primer

<400>  22
tgcacaggag ccaagagtga a                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP reverse primer

<400>  23
cacatcacag ctccccacca                                                   20


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTCH1 forward primer

<400>  24
ggcagcggta gtagtggtgt tc                                                22


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTCH1 reverse primer

<400>  25
tgtagcgggt attgtcgtgt gtg                                               23


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SMOH forward primer

<400>  26
gggaggctac ttcctcatcc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SMOH reverse primer

<400>  27
ggcagctgaa ggtaatgagc                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TP53 forward primer

<400>  28
gtggaaggaa atttgcgtgt                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TP53 reverse primer

<400>  29
ccagtgtgat gatggtgagg                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SUFUH forward primer

<400>  30
ggctttgagt tgacctttcg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SUFUH reverse primer

<400>  31
catctgtggg tcctctgtca                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'UTR forward primer for sequencing

<400>  32
gagacggggt ttcactgtgt                                                   20


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'UTR reverse primer for sequencing

<400>  33
cactcggtga aatcagggta a                                                 21


<210>  34
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<400>  34
srscsattan s                                                            11


<210>  35
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  35

Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn Gln Thr Gln 
1               5                   10                  15      


Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln Thr Trp Cys 
            20                  25                  30          


Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
        35                  40                  45  


<210>  36
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Glu Glu Gln Gln Pro Glu Pro Lys Ser Gln Arg Asp Ser Ala Leu 
1               5                   10                  15      


Gly Gly Ala Ala Ala Ala Thr Pro Gly Gly Leu Ser Leu Ser Leu Ser 
            20                  25                  30          


Pro Gly Ala Ser Gly Ser Ser Gly Ser Gly Ser Asp Gly Asp Ser Val 
        35                  40                  45              


Pro Val Ser Pro Gln Pro Ala Pro Pro Ser Pro Pro Ala Ala Pro Cys 
    50                  55                  60                  


Leu Pro Pro Leu Ala His His Pro His Leu Pro Pro His Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Gln His Leu Ala Ala Pro Ala His Gln Pro Gln Pro Ala 
                85                  90                  95      


Ala Gln Leu His Arg Thr Thr Asn Phe Phe Ile Asp Asn Ile Leu Arg 
            100                 105                 110         


Pro Asp Phe Gly Cys Lys Lys Glu Gln Pro Pro Pro Gln Leu Leu Val 
        115                 120                 125             


Ala Ala Ala Ala Arg Gly Gly Ala Gly Gly Gly Gly Arg Val Glu Arg 
    130                 135                 140                 


Asp Arg Gly Gln Thr Ala Ala Gly Arg Asp Pro Val His Pro Leu Gly 
145                 150                 155                 160 


Thr Arg Ala Pro Gly Ala Ala Ser Leu Leu Cys Ala Pro Asp Ala Asn 
                165                 170                 175     


Cys Gly Pro Pro Asp Gly Ser Gln Pro Ala Ala Ala Gly Ala Gly Ala 
            180                 185                 190         


Ser Lys Ala Gly Asn Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Pro Ser Asp Thr Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Ala Gly Ser Pro Gly Ala Gln Gly Thr 
225                 230                 235                 240 


Lys Tyr Pro Glu His Gly Asn Pro Ala Ile Leu Leu Met Gly Ser Ala 
                245                 250                 255     


Asn Gly Gly Pro Val Val Lys Thr Asp Ser Gln Gln Pro Leu Val Trp 
            260                 265                 270         


Pro Ala Trp Val Tyr Cys Thr Arg Tyr Ser Asp Arg Pro Ser Ser Gly 
        275                 280                 285             


Pro Arg Thr Arg Lys Leu Lys Lys Lys Lys 
    290                 295             


<210>  37
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  37

Val Pro Ser Ile Leu Ser Leu Ile Gln Thr Pro Lys Cys Leu His Thr 
1               5                   10                  15      


Tyr Phe Ser Met Thr Thr Met Gly Asn Thr 
            20                  25      


<210>  38
<211>  296
<212>  PRT
<213>  Drosophila melanogaster

<400>  38

Met Ala Leu Glu Asp Arg Cys Ser Pro Gln Ser Ala Pro Ser Pro Ile 
1               5                   10                  15      


Thr Leu Gln Met Gln His Leu His His Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Met Gln His Leu His Gln Leu Gln Gln Leu Gln Gln 
        35                  40                  45              


Leu His Gln Gln Gln Leu Ala Ala Gly Val Phe His His Pro Ala Met 
    50                  55                  60                  


Ala Phe Asp Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala His Ala His Ala Ala Ala Leu Gln Gln Arg Leu Ser Gly Ser Gly 
                85                  90                  95      


Ser Pro Ala Ser Cys Ser Thr Pro Ala Ser Ser Thr Pro Leu Thr Ile 
            100                 105                 110         


Lys Glu Glu Glu Ser Asp Ser Val Ile Gly Asp Met Ser Phe His Asn 
        115                 120                 125             


Gln Thr His Thr Thr Asn Glu Glu Glu Glu Ala Glu Glu Asp Asp Asp 
    130                 135                 140                 


Ile Asp Val Asp Val Asp Asp Thr Ser Ala Gly Gly Arg Leu Pro Pro 
145                 150                 155                 160 


Pro Ala His Gln Gln Gln Ser Thr Ala Lys Pro Ser Leu Ala Phe Ser 
                165                 170                 175     


Ile Ser Asn Ile Leu Ser Asp Arg Phe Gly Asp Val Gln Lys Pro Gly 
            180                 185                 190         


Lys Ser Met Glu Asn Gln Ala Ser Ile Phe Arg Pro Phe Glu Ala Ser 
        195                 200                 205             


Arg Ser Gln Thr Ala Thr Pro Ser Ala Phe Thr Arg Val Asp Leu Leu 
    210                 215                 220                 


Glu Phe Ser Arg Gln Gln Gln Ala Ala Ala Ala Ala Ala Thr Ala Ala 
225                 230                 235                 240 


Met Met Leu Glu Arg Ala Asn Phe Leu Asn Cys Phe Asn Pro Ala Ala 
                245                 250                 255     


Tyr Pro Arg Ile His Glu Glu Ile Val Gln Ser Arg Leu Arg Arg Ser 
            260                 265                 270         


Ala Ala Asn Ala Val Ile Pro Pro Pro Met Ser Ser Lys Met Ser Asp 
        275                 280                 285             


Ala Asn Pro Glu Lys Ser Ala Leu 
    290                 295     


<210>  39
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Asp Ala Thr Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro 
1               5                   10                  15      


Ser Ile Gln Ala Ile Pro Cys Ala Pro 
            20                  25  


<210>  40
<211>  16
<212>  PRT
<213>  Drosophila melanogaster

<400>  40

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glioma targeting peptide

<400>  41

Cys Arg Thr Ile Gly Pro Ser Val Cys 
1               5                   


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG Tag

<400>  42

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA Tag

<400>  43

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  44
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WRPW motif of the hairy-related protein

<400>  44

Trp Arg Pro Trp 
1               


