                         SEQUENCE LISTING

<110>  INSERM
       ORIBASE PHARMA
 
<120>  ANTI-AXL ANTIBODIES AND USES THEREOF

<130>  BIO11082 ROBERT / MC

<160>  11    

<170>  PatentIn version 3.3

<210>  1
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  VH chain

<400>  1

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Ser Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Arg Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Tyr Gly Ser Ser Leu Tyr Pro Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR1

<400>  2

Asn Tyr Ala Val His 
1               5   


<210>  3
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR2

<400>  3

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR3

<400>  4

Tyr Tyr Gly Ser Ser Leu Tyr Pro Met Asp Tyr 
1               5                   10      


<210>  5
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  VL chain

<400>  5

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys 
            100                 105                 110         


<210>  6
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR1

<400>  6

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  7
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR2

<400>  7

Arg Met Ser Asn Leu Ala 
1               5       


<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR3

<400>  8

Met Gln His Leu Glu Tyr Pro Trp Thr 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  FN3D1 epitope

<400>  9

Asn Leu His Leu Val Ser Arg 
1               5           


<210>  10
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  FN3D2 epitope

<400>  10

Val Leu Met Asp Ile Gly Leu Arg Gln Glu Val Thr Leu Glu 
1               5                   10                  


<210>  11
<211>  652
<212>  PRT
<213>  Artificial

<220>
<223>  hAxl-hFc

<400>  11

Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
1               5                   10                  15      


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
            20                  25                  30          


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
        35                  40                  45              


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
    50                  55                  60                  


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
65                  70                  75                  80  


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
                85                  90                  95      


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
            100                 105                 110         


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
        115                 120                 125             


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
    130                 135                 140                 


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
145                 150                 155                 160 


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
                165                 170                 175     


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
            180                 185                 190         


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
        195                 200                 205             


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
    210                 215                 220                 


His Cys Thr Leu Gln Ala Val Leu Ser Asn Asp Gly Met Gly Ile Gln 
225                 230                 235                 240 


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
                245                 250                 255     


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
            260                 265                 270         


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
        275                 280                 285             


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
    290                 295                 300                 


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
305                 310                 315                 320 


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
                325                 330                 335     


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
            340                 345                 350         


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
        355                 360                 365             


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
    370                 375                 380                 


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
385                 390                 395                 400 


Ser Thr Pro Ala Phe Ser Trp Pro Asp Ile Glu Gly Arg Met Asp Pro 
                405                 410                 415     


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            420                 425                 430         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        435                 440                 445             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    450                 455                 460                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
465                 470                 475                 480 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                485                 490                 495     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            500                 505                 510         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        515                 520                 525             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    530                 535                 540                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
545                 550                 555                 560 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                565                 570                 575     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            580                 585                 590         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        595                 600                 605             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    610                 615                 620                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
625                 630                 635                 640 


Ser Leu Ser Pro Gly Lys His His His His His His 
                645                 650         


