                         SEQUENCE LISTING

<110>  PIERRE FABRE MEDICAMENT
       KLINGUER-HAMOUR, Christine
 
<120>  Anti-CXCR4 antibody with effector functions and its use for the 
       treatment of cancer

<130>  361039D29882

<150>  EP 11305773.1
<151>  2011-06-20


<150>  US 61/499,004
<151>  2011-06-20

<160>  73    

<170>  PatentIn version 3.3

<210>  1
<211>  8
<212>  PRT
<213>  mus musculus

<400>  1

Gly Phe Thr Phe Thr Asp Asn Tyr 
1               5               


<210>  2
<211>  10
<212>  PRT
<213>  mus musculus

<400>  2

Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr 
1               5                   10  


<210>  3
<211>  11
<212>  PRT
<213>  mus musculus

<400>  3

Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr 
1               5                   10      


<210>  4
<211>  12
<212>  PRT
<213>  mus musculus

<400>  4

Gln Ser Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  5
<211>  3
<212>  PRT
<213>  mus musculus

<400>  5

Trp Ala Ser 
1           


<210>  6
<211>  8
<212>  PRT
<213>  mus musculus

<400>  6

Met Gln Ser Phe Asn Leu Arg Thr 
1               5               


<210>  7
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  10

Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  11

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  12
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  13

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  14
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  15

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Arg Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  16
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  17

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  18
<211>  449
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  19
<211>  449
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  20
<211>  449
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  21
<211>  449
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  21

Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  22
<211>  219
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  23
<211>  219
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  23

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  24
<211>  219
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  25
<211>  219
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  25

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  26
<211>  219
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  26

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Arg Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  27
<211>  219
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  27

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  28
<211>  219
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanizd antibody

<400>  28

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  29
<211>  24
<212>  DNA
<213>  mus musculus

<400>  29
gggttcacct tcactgataa ctac                                            24


<210>  30
<211>  30
<212>  DNA
<213>  mus musculus

<400>  30
attagaaaca aagctaatgg ttacacaaca                                      30


<210>  31
<211>  33
<212>  DNA
<213>  mus musculus

<400>  31
gcaagagatg tcggttccaa ctactttgac tac                                  33


<210>  32
<211>  36
<212>  DNA
<213>  mus musculus

<400>  32
cagagtctgt tcaacagtcg aacccgaaag aactac                               36


<210>  33
<211>  9
<212>  DNA
<213>  mus musculus

<400>  33
tgggcatcc                                                              9


<210>  34
<211>  24
<212>  DNA
<213>  mus musculus

<400>  34
atgcaatctt ttaatcttcg gacg                                            24


<210>  35
<211>  360
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  35
gaggtgcagc tggtggagtc tggcggagga ctggtgcagc ccggcagaag cctgagactg     60

agctgcaccg ccagcggctt caccttcacc gacaactaca tgtcctgggt gcgccaggcc    120

cctggaaagg gcctggaatg ggtgggcttc atccggaaca aggccaacgg ctacaccaca    180

gagtacgccg ccagcgtgaa gggccggttc accatcagcc gggacgacag caagagcatt    240

gcctacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccagg    300

gacgtgggca gcaactactt cgactactgg ggccagggca cactggtgac cgtgtctagc    360


<210>  36
<211>  360
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  36
gaggtgcagc tggtggagtc tggcggagga ctggtgcagc ccggcagaag cctgagactg     60

agctgcaccg ccagcggctt caccttcacc gacaactaca tgtcctgggt gcgccaggcc    120

cctggaaagg gcctggaatg ggtgggcttc atccggaaca aggccaacgg ctacaccaca    180

gagtacgccg ccagcgtgaa gggccggttc accatcagcc gggacaacag caagagcatt    240

gcctacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccagg    300

gacgtgggca gcaactactt cgactactgg ggccagggca cactggtgac cgtgtctagc    360


<210>  37
<211>  360
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  37
gaggtgcagc tggtggagtc tggcggagga ctggtgcagc ccggcagaag cctgagactg     60

agctgcaccg ccagcggctt caccttcacc gacaactaca tgtcctgggt gcgccaggcc    120

cctggaaagg gcctggaatg gctgggcttc atccggaaca aggccaacgg ctacaccaca    180

gagtacgccg ccagcgtgaa gggccggttc accatcagcc gggacaacag caagagcatt    240

gcctacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccagg    300

gacgtgggca gcaactactt cgactactgg ggccagggca cactggtgac cgtgtctagc    360


<210>  38
<211>  360
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  38
gaggtgaacc tggtggagtc tggcggagga ctggtgcagc ccggcagaag cctgagactg     60

agctgcaccg ccagcggctt caccttcacc gacaactaca tgtcctgggt gcgccaggcc    120

cctggaaagg gcctggaatg gctgggcttc atccggaaca aggccaacgg ctacaccaca    180

gactacgccg ccagcgtgag aggccggttc accatcagcc gggacaacag caagagcatt    240

ctgtacctgc agatgaacgc cctgcggacc gaggacaccg ccgtgtacta ctgcgccagg    300

gacgtgggca gcaactactt cgactactgg ggccagggca cactggtgac cgtgtctagc    360


<210>  39
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  39
gacatcgtga tgacccagag ccccgatagc ctggccgtgt ctctgggcga gcgggccacc     60

atcaactgca agagcagcca gagcctgttc aacagccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc cagcacaaga    180

gaaagcggcg tgcccgaccg cttttctggc agcggcagcg gcaccgactt caccctgacc    240

atcagctccc tgcaggccga ggacgtggcc gtgtactact gcatgcagag cttcaacctg    300

cggaccttcg gccagggcac caaggtggag atcaag                              336


<210>  40
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  40
gacatcgtga tgacccagag ccccgatagc ctggccgtgt ctctgggcga gcgggccacc     60

atcaactgca agagcagcca gagcctgttc aacagccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc cagcgccaga    180

gacagcggcg tgcccgaccg cttttctggc agcggcagcg gcaccgactt caccctgacc    240

atcagctccc tgcaggccga ggacgtggcc gtgtactact gcatgcagag cttcaacctg    300

cggaccttcg gccagggcac caaggtggag atcaag                              336


<210>  41
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  41
gacatcgtga tgacccagag ccccagcagc ctggccgtgt ctctgggcga gcgggccacc     60

atgagctgca agagcagcca gagcctgttc aacagccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagtccccc aagctgctga tctactgggc cagcgccaga    180

gatagcggcg tgcccgctcg ctttaccggc agcggcagcg agacctactt caccctgacc    240

atcagccggg tgcaggccga ggacctcgcc gtgtactact gcatgcagag cttcaacctg    300

cggaccttcg gccagggcac caaggtggag atcaag                              336


<210>  42
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  42
gacatcgtga tgacccagtc ccccgactcc ctggccgtgt ctctgggcga gcgggccacc     60

atgtcctgca agtcctccca gtccctgttc aactcccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc ctctgctaga    180

gactctggcg tgcccgacag attctccggc tccggcagcg agacatactt caccctgacc    240

atctcccggg tgcaggccga ggatctggcc gtgtactact gcatgcagtc cttcaacctg    300

cggaccttcg gccagggcac caaggtggaa atcaag                              336


<210>  43
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  43
gacatcgtga tgacccagtc ccccgactcc ctggccgtgt ctctgggcga gcgggccacc     60

atgtcctgca agtcctccca gtccctgttc aactcccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc ctctgctaga    180

gactctggcg tgcccgacag attcaccggc tccggcagcg agacatactt caccctgacc    240

atctcccggg tgcaggccga ggatgtggcc gtgtactact gcatgcagtc cttcaacctg    300

cggaccttcg gccagggcac caaggtggaa atcaag                              336


<210>  44
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  44
gacatcgtga tgacccagtc ccccgactcc ctggccgtgt ctctgggcga gcgggccacc     60

atgtcctgca agtcctccca gtccctgttc aactcccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc ctctgctaga    180

gactctggcg tgcccgacag attcaccggc tccggcagcg agacatactt caccctgacc    240

atctccagcc tgcaggccga ggatctggcc gtgtactact gcatgcagtc cttcaacctg    300

cggaccttcg gccagggcac caaggtggaa atcaag                              336


<210>  45
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  45
gacatcgtga tgacccagag ccccgatagc ctggccgtgt ctctgggcga gcgggccacc     60

atcaactgca agagcagcca gagcctgttc aacagccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc cagcgccaga    180

gatagcggcg tgcccgaccg ctttaccggc agcggcagcg agacctactt caccctgacc    240

atcagctccc tgcaggccga ggacgtggcc gtgtactact gcatgcagag cttcaacctg    300

cggaccttcg gccagggcac caaggtggag atcaag                              336


<210>  46
<211>  1347
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  46
gaggtgcagc tggtggagtc tggcggagga ctggtgcagc ccggcagaag cctgagactg     60

agctgcaccg ccagcggctt caccttcacc gacaactaca tgtcctgggt gcgccaggcc    120

cctggaaagg gcctggaatg ggtgggcttc atccggaaca aggccaacgg ctacaccaca    180

gagtacgccg ccagcgtgaa gggccggttc accatcagcc gggacgacag caagagcatt    240

gcctacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccagg    300

gacgtgggca gcaactactt cgactactgg ggccagggca cactggtgac cgtgtctagc    360

gccagcacaa agggcccaag cgtgttcccg ctagccccca gcagcaagag caccagcggc    420

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc    480

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagcagc    540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc    600

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagag agtggagccc    660

aagagctgtg acaagaccca cacctgcccc ccctgcccag cccccgagct gctgggcgga    720

cccagcgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag cagaaccccc    780

gaggtgacct gtgtggtggt ggacgtgtcc cacgaggacc cagaggtgaa gttcaactgg    840

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ccagagagga gcagtacaac    900

agcacctaca gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaag    960

gagtacaagt gtaaggtgtc caacaaggcc ctgccagccc caatcgaaaa gaccatcagc   1020

aaggccaagg gccagccaag agagccccag gtgtacaccc tgccacccag cagggaggag   1080

atgaccaaga accaggtgtc cctgacctgt ctggtgaagg gcttctaccc aagcgacatc   1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac ccccccagtg   1200

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg   1260

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa ccactacacc   1320

cagaagagcc tgagcctgtc cccaggc                                       1347


<210>  47
<211>  1347
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  47
gaggtgcagc tggtggagtc tggcggagga ctggtgcagc ccggcagaag cctgagactg     60

agctgcaccg ccagcggctt caccttcacc gacaactaca tgtcctgggt gcgccaggcc    120

cctggaaagg gcctggaatg ggtgggcttc atccggaaca aggccaacgg ctacaccaca    180

gagtacgccg ccagcgtgaa gggccggttc accatcagcc gggacaacag caagagcatt    240

gcctacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccagg    300

gacgtgggca gcaactactt cgactactgg ggccagggca cactggtgac cgtgtctagc    360

gccagcacaa agggcccaag cgtgttcccg ctagccccca gcagcaagag caccagcggc    420

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc    480

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagcagc    540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc    600

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagag agtggagccc    660

aagagctgtg acaagaccca cacctgcccc ccctgcccag cccccgagct gctgggcgga    720

cccagcgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag cagaaccccc    780

gaggtgacct gtgtggtggt ggacgtgtcc cacgaggacc cagaggtgaa gttcaactgg    840

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ccagagagga gcagtacaac    900

agcacctaca gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaag    960

gagtacaagt gtaaggtgtc caacaaggcc ctgccagccc caatcgaaaa gaccatcagc   1020

aaggccaagg gccagccaag agagccccag gtgtacaccc tgccacccag cagggaggag   1080

atgaccaaga accaggtgtc cctgacctgt ctggtgaagg gcttctaccc aagcgacatc   1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac ccccccagtg   1200

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg   1260

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa ccactacacc   1320

cagaagagcc tgagcctgtc cccaggc                                       1347


<210>  48
<211>  1347
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  48
gaggtgcagc tggtggagtc tggcggagga ctggtgcagc ccggcagaag cctgagactg     60

agctgcaccg ccagcggctt caccttcacc gacaactaca tgtcctgggt gcgccaggcc    120

cctggaaagg gcctggaatg gctgggcttc atccggaaca aggccaacgg ctacaccaca    180

gagtacgccg ccagcgtgaa gggccggttc accatcagcc gggacaacag caagagcatt    240

gcctacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccagg    300

gacgtgggca gcaactactt cgactactgg ggccagggca cactggtgac cgtgtctagc    360

gccagcacaa agggcccaag cgtgttcccg ctagccccca gcagcaagag caccagcggc    420

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc    480

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagcagc    540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc    600

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagag agtggagccc    660

aagagctgtg acaagaccca cacctgcccc ccctgcccag cccccgagct gctgggcgga    720

cccagcgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag cagaaccccc    780

gaggtgacct gtgtggtggt ggacgtgtcc cacgaggacc cagaggtgaa gttcaactgg    840

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ccagagagga gcagtacaac    900

agcacctaca gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaag    960

gagtacaagt gtaaggtgtc caacaaggcc ctgccagccc caatcgaaaa gaccatcagc   1020

aaggccaagg gccagccaag agagccccag gtgtacaccc tgccacccag cagggaggag   1080

atgaccaaga accaggtgtc cctgacctgt ctggtgaagg gcttctaccc aagcgacatc   1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac ccccccagtg   1200

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg   1260

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa ccactacacc   1320

cagaagagcc tgagcctgtc cccaggc                                       1347


<210>  49
<211>  1347
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  49
gaggtgaacc tggtggagtc tggcggagga ctggtgcagc ccggcagaag cctgagactg     60

agctgcaccg ccagcggctt caccttcacc gacaactaca tgtcctgggt gcgccaggcc    120

cctggaaagg gcctggaatg gctgggcttc atccggaaca aggccaacgg ctacaccaca    180

gactacgccg ccagcgtgag aggccggttc accatcagcc gggacaacag caagagcatt    240

ctgtacctgc agatgaacgc cctgcggacc gaggacaccg ccgtgtacta ctgcgccagg    300

gacgtgggca gcaactactt cgactactgg ggccagggca cactggtgac cgtgtctagc    360

gccagcacaa agggcccaag cgtgttcccg ctagccccca gcagcaagag caccagcggc    420

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc    480

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagcagc    540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc    600

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagag agtggagccc    660

aagagctgtg acaagaccca cacctgcccc ccctgcccag cccccgagct gctgggcgga    720

cccagcgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag cagaaccccc    780

gaggtgacct gtgtggtggt ggacgtgtcc cacgaggacc cagaggtgaa gttcaactgg    840

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ccagagagga gcagtacaac    900

agcacctaca gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaag    960

gagtacaagt gtaaggtgtc caacaaggcc ctgccagccc caatcgaaaa gaccatcagc   1020

aaggccaagg gccagccaag agagccccag gtgtacaccc tgccacccag cagggaggag   1080

atgaccaaga accaggtgtc cctgacctgt ctggtgaagg gcttctaccc aagcgacatc   1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac ccccccagtg   1200

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg   1260

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa ccactacacc   1320

cagaagagcc tgagcctgtc cccaggc                                       1347


<210>  50
<211>  657
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  50
gacatcgtga tgacccagag ccccgatagc ctggccgtgt ctctgggcga gcgggccacc     60

atcaactgca agagcagcca gagcctgttc aacagccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc cagcacaaga    180

gaaagcggcg tgcccgaccg cttttctggc agcggcagcg gcaccgactt caccctgacc    240

atcagctccc tgcaggccga ggacgtggcc gtgtactact gcatgcagag cttcaacctg    300

cggaccttcg gccagggcac caaggtggag atcaagcgta cggtggccgc tcccagcgtg    360

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    480

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    600

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgc       657


<210>  51
<211>  657
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  51
gacatcgtga tgacccagag ccccgatagc ctggccgtgt ctctgggcga gcgggccacc     60

atcaactgca agagcagcca gagcctgttc aacagccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc cagcgccaga    180

gacagcggcg tgcccgaccg cttttctggc agcggcagcg gcaccgactt caccctgacc    240

atcagctccc tgcaggccga ggacgtggcc gtgtactact gcatgcagag cttcaacctg    300

cggaccttcg gccagggcac caaggtggag atcaagcgta cggtggccgc tcccagcgtg    360

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    480

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    600

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgc       657


<210>  52
<211>  657
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  52
gacatcgtga tgacccagag ccccagcagc ctggccgtgt ctctgggcga gcgggccacc     60

atgagctgca agagcagcca gagcctgttc aacagccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagtccccc aagctgctga tctactgggc cagcgccaga    180

gatagcggcg tgcccgctcg ctttaccggc agcggcagcg agacctactt caccctgacc    240

atcagccggg tgcaggccga ggacctcgcc gtgtactact gcatgcagag cttcaacctg    300

cggaccttcg gccagggcac caaggtggag atcaagcgta cggtggccgc tcccagcgtg    360

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    480

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    600

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgc       657


<210>  53
<211>  657
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  53
gacatcgtga tgacccagtc ccccgactcc ctggccgtgt ctctgggcga gcgggccacc     60

atgtcctgca agtcctccca gtccctgttc aactcccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc ctctgctaga    180

gactctggcg tgcccgacag attctccggc tccggcagcg agacatactt caccctgacc    240

atctcccggg tgcaggccga ggatctggcc gtgtactact gcatgcagtc cttcaacctg    300

cggaccttcg gccagggcac caaggtggaa atcaagcgta cggtggccgc tcccagcgtg    360

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    480

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    600

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgc       657


<210>  54
<211>  657
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  54
gacatcgtga tgacccagtc ccccgactcc ctggccgtgt ctctgggcga gcgggccacc     60

atgtcctgca agtcctccca gtccctgttc aactcccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc ctctgctaga    180

gactctggcg tgcccgacag attcaccggc tccggcagcg agacatactt caccctgacc    240

atctcccggg tgcaggccga ggatgtggcc gtgtactact gcatgcagtc cttcaacctg    300

cggaccttcg gccagggcac caaggtggaa atcaagcgta cggtggccgc tcccagcgtg    360

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    480

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    600

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgc       657


<210>  55
<211>  657
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  55
gacatcgtga tgacccagtc ccccgactcc ctggccgtgt ctctgggcga gcgggccacc     60

atgtcctgca agtcctccca gtccctgttc aactcccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc ctctgctaga    180

gactctggcg tgcccgacag attcaccggc tccggcagcg agacatactt caccctgacc    240

atctccagcc tgcaggccga ggatctggcc gtgtactact gcatgcagtc cttcaacctg    300

cggaccttcg gccagggcac caaggtggaa atcaagcgta cggtggccgc tcccagcgtg    360

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    480

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    600

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgc       657


<210>  56
<211>  657
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  56
gacatcgtga tgacccagag ccccgatagc ctggccgtgt ctctgggcga gcgggccacc     60

atcaactgca agagcagcca gagcctgttc aacagccgga cccggaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc cagcgccaga    180

gatagcggcg tgcccgaccg ctttaccggc agcggcagcg agacctactt caccctgacc    240

atcagctccc tgcaggccga ggacgtggcc gtgtactact gcatgcagag cttcaacctg    300

cggaccttcg gccagggcac caaggtggag atcaagcgta cggtggccgc tcccagcgtg    360

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    480

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    600

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgc       657


<210>  57
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  optimized codons

<400>  57
cagtccctgt tcaactcccg gacccggaag aactac                               36


<210>  58
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  optimized codons

<400>  58
tgggcctct                                                              9


<210>  59
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized antibody

<400>  59
atgcagtcct tcaacctgcg gacc                                            24


<210>  60
<211>  110
<212>  PRT
<213>  human

<400>  60

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  61
<211>  15
<212>  PRT
<213>  human

<400>  61

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  62
<211>  98
<212>  PRT
<213>  human

<400>  62

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  63
<211>  106
<212>  PRT
<213>  human

<400>  63

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  64
<211>  329
<212>  PRT
<213>  human

<400>  64

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  65
<211>  330
<212>  DNA
<213>  human

<400>  65
gcccccgagc tgctgggcgg acccagcgtg ttcctgttcc cccccaagcc caaggacacc     60

ctgatgatca gcagaacccc cgaggtgacc tgtgtggtgg tggacgtgtc ccacgaggac    120

ccagaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag    180

cccagagagg agcagtacaa cagcacctac agggtggtgt ccgtgctgac cgtgctgcac    240

caggactggc tgaacggcaa ggagtacaag tgtaaggtgt ccaacaaggc cctgccagcc    300

ccaatcgaaa agaccatcag caaggccaag                                     330


<210>  66
<211>  45
<212>  DNA
<213>  human

<400>  66
gagcccaaga gctgtgacaa gacccacacc tgccccccct gccca                     45


<210>  67
<211>  294
<212>  DNA
<213>  human

<400>  67
gccagcacca agggcccaag cgtgttcccc ctggccccca gcagcaagag caccagcggc     60

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc    120

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagcagc    180

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc    240

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagag agtg          294


<210>  68
<211>  318
<212>  DNA
<213>  human

<400>  68
ggccagccaa gagagcccca ggtgtacacc ctgccaccca gcagggagga gatgaccaag     60

aaccaggtgt ccctgacctg tctggtgaag ggcttctacc caagcgacat cgccgtggag    120

tgggagagca acggccagcc cgagaacaac tacaagacca cccccccagt gctggacagc    180

gacggcagct tcttcctgta cagcaagctg accgtggaca agagcagatg gcagcagggc    240

aacgtgttca gctgctccgt gatgcacgag gccctgcaca accactacac ccagaagagc    300

ctgagcctgt ccccaggc                                                  318


<210>  69
<211>  987
<212>  DNA
<213>  human

<400>  69
gccagcacca agggcccaag cgtgttcccc ctggccccca gcagcaagag caccagcggc     60

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc    120

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagcagc    180

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc    240

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagag agtggagccc    300

aagagctgtg acaagaccca cacctgcccc ccctgcccag cccccgagct gctgggcgga    360

cccagcgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag cagaaccccc    420

gaggtgacct gtgtggtggt ggacgtgtcc cacgaggacc cagaggtgaa gttcaactgg    480

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ccagagagga gcagtacaac    540

agcacctaca gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaag    600

gagtacaagt gtaaggtgtc caacaaggcc ctgccagccc caatcgaaaa gaccatcagc    660

aaggccaagg gccagccaag agagccccag gtgtacaccc tgccacccag cagggaggag    720

atgaccaaga accaggtgtc cctgacctgt ctggtgaagg gcttctaccc aagcgacatc    780

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac ccccccagtg    840

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg    900

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa ccactacacc    960

cagaagagcc tgagcctgtc cccaggc                                        987


<210>  70
<211>  469
<212>  PRT
<213>  artificial sequence

<220>
<223>  chimeric antibody

<400>  70

Met Lys Met Trp Leu Asn Trp Val Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      


Ile Gln Cys Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Asn Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
    50                  55                  60                  


Glu Trp Leu Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Asp 
65                  70                  75                  80  


Tyr Ser Ala Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Ser 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  71
<211>  239
<212>  PRT
<213>  artificial sequence

<220>
<223>  chimeric antibody

<400>  71

Met Glu Ser Gln Thr Leu Val Phe Ile Ser Ile Leu Leu Trp Leu Tyr 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg 
65                  70                  75                  80  


Asp Ser Gly Val Pro Ala Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Ser Phe Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  72
<211>  1404
<212>  DNA
<213>  artificial sequence

<220>
<223>  chimeric antibody

<400>  72
atgaagatgt ggctgaactg ggtgttcctg gtgaccctgc tgaacggcat ccagtgcgaa     60

gtgaacctgg tggagtctgg cggcggactg gtgcagcctg ggggcagcct gagactgagc    120

tgcgccacct ccggcttcac cttcaccgac aactacatga gctgggtgcg ccagccccct    180

ggcaaggccc tggaatggct gggcttcatc cggaacaagg ccaacggcta caccaccgac    240

tacagcgcca gcgtgcgggg cagattcacc atcagccggg acaacagcca gagcatcctg    300

tacctgcaga tgaacgccct gcgggccgag gacagcgcca cctactactg tgcccgggac    360

gtgggcagca actacttcga ctactggggc cagggcacca cactgaccgt gtccagcgcc    420

agcaccaagg gcccctccgt gttcccgcta gcccccagca gcaagagcac cagcggcggc    480

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    540

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc    600

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac    660

atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag    720

agctgtgaca agacccacac ctgccccccc tgcccagccc ccgagctgct gggcggaccc    780

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag    840

gtgacctgtg tggtggtgga cgtgtcccac gaggacccag aggtgaagtt caactggtac    900

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc    960

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag   1020

tacaagtgta aggtgtccaa caaggccctg ccagccccaa tcgaaaagac catcagcaag   1080

gccaagggcc agccaagaga gccccaggtg tacaccctgc cacccagcag ggaggagatg   1140

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccaag cgacatcgcc   1200

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg   1260

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag   1320

cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1380

aagagcctga gcctgtcccc aggc                                          1404


<210>  73
<211>  717
<212>  DNA
<213>  artificial sequence

<220>
<223>  chimeric antibody

<400>  73
atggagtcac agactctggt cttcatatcc atactgctct ggttatatgg tacctgtggg     60

gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact    120

atgagctgca aatccagtca gagtctgttc aacagtcgaa cccgaaagaa ctacttggct    180

tggtaccagc agaagccagg gcagtctcct aaactgctga tctactgggc atccgctagg    240

gattctgggg tccctgctcg cttcacaggc agtggatctg agacatattt cactctcacc    300

atcagccgtg tgcaggctga agacctggca gtttattact gcatgcaatc ttttaatctt    360

cggacgttcg gtggaggcac caagctggaa atcaaacgta cggtggccgc tcccagcgtg    420

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    480

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    540

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    660

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgc       717

