﻿               SEQUENCE LISTING / SEQUENZPROTOKOLL

<110> Universität Leipzig

<120> Modifizierte antibiotische Peptide mit variabler systemischer Freisetzung

<130> 00401P0054DEWO

<150> DE 10 2011 118 029.3

<151> 20.06.2011

<160> 66

<170> BiSSAP 1.0

<210> 1
<211> 18
<212> PRT
<213> Apis mellifera

<400> 1
Gly Asn Asn Arg Pro Val Tyr Ile Pro Gln Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Ile 
        

<210> 2
<211> 18
<212> PRT
<213> Apis mellifera

<400> 2
Gly Asn Asn Arg Pro Val Tyr Ile Pro Gln Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 
        

<210> 3
<211> 19
<212> PRT
<213> Drosophila melanogaster

<400> 3
Gly Lys Pro Arg Pro Tyr Ser Pro Arg Pro Thr Ser His Pro Arg Pro 
1               5                   10                   15    
Ile Arg Val 
            

<210> 4
<211> 16
<212> PRT
<213> Myrmecia gulosa

<400> 4
Gly Arg Pro Asn Pro Val Asn Asn Lys Pro Thr Pro Tyr Pro His Leu 
1               5                   10                   15    

<210> 5
<211> 20
<212> PRT
<213> Pyrrhocoris apterus

<220>
<221> misc_feature
<222> (20)..(20)
<223> Xaa is Asparagine amide

<400> 5
Val Asp Lys Gly Ser Tyr Leu Pro Arg Pro Thr Pro Pro Arg Pro Ile 
1               5                   10                   15    
Tyr Asn Arg Xaa
            20

<210> 6
<211> 15
<212> PRT
<213> Palomena prasina

<400> 6
Val Asp Lys Pro Asp Tyr Arg Pro Arg Pro Arg Pro Pro Asn Met 
1               5                   10                   15

<210> 7
<211> 34
<212> PRT
<213> Oncopeltus fasciatus

<400> 7
Glu Val Ser Leu Lys Gly Glu Gly Gly Ser Asn Lys Gly Phe Ile Gln 
1               5                   10                   15    
Gly Ser Gly Thr Lys Thr Leu Phe Gln Asp Asp Lys Thr Lys Leu Asp 
            20                   25                  30        
Gly Thr 
        
<210> 8
<211> 20
<212> PRT
<213> Oncopeltus fasciatus

<220>
<221> misc_feature
<222> (11)..(11)
<223> Xaa is Pro or any other naturally occurring amino acid
<220>
<221> misc_feature
<222> (19)..(20)
<223> Optional residues

<400>  8

Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Xaa Pro Pro Arg Arg Ile 
1               5                   10                  15      
Tyr Asn Asn Arg 

<210> 9
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine

<400> 9
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 10
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine

<400> 10
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 11
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is Ornithine

<400> 11
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is Ornithine

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is Ornithine amide

<400>  12
Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Arg Xaa Ile 
1               5                   10                  15      
Tyr Asn Xaa

<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is tert-Leucine 

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is Ornithine amide

<400>  13
Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Xaa Arg Xaa Xaa 
1               5                   10                  15      
Tyr Asn Xaa


<210> 14
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (18)..(18)
<223> Xaa is Leucin amide

<400> 14
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Xaa 

<210> 15
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (17)..(17)
<223> Xaa is Ornithine

<220>
<221> misc_feature
<222> (18)..(18)
<223> Xaa is Leucin amide

<400> 15
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Xaa Xaa 

<210> 16
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<400> 16
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 17
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine with Polyethylene glycole 750 linked directly to delta-NH2 of Ornithine 

<400> 17
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 18
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine with Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 18
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 19
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine with Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 19
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 20
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine with Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 20
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine with Polyethylene glycole 750 bound directly to N-terminus of Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 21
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 22
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine with Polyethylene glycole 750 bound directly to N-terminus of Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 22
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 


<210> 23
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine with Polyethylene glycole 5000 bound directly to N-terminus of Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 23
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 24
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine with Polyethylene glycole 20000 bound to N-terminus of Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 24
Xaa Asn Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 25
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 25
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 26
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 26
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 27
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 27
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 28
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with Gly-Ala-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 28
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 29
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with Polyethylene glycole 750 bound to N-terminus of Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 29
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 30
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with Polyethylene glycole 750 bound to N-terminus of Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 30
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 31
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with Polyethylene glycole 750 bound to N-terminus of Gly-Ala-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 31
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 32
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with thiol modified Polyethylene glycole 750 bound to iodoacetylated N-terminus of Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 32
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 33
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with thiol modified Polyethylene glycole 750 bound to iodoacetylated N-terminus of Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 33
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 34
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with thiol modified Polyethylene glycole 750 bound to iodoacetylated N-terminus of Gly-Ala-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 34
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 35
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with thiol modified Polyethylene glycole 5000 bound to iodoacetylated N-terminus of Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 35
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 36
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with thiol modified Polyethylene glycole 5000 bound to iodoacetylated N-terminus of Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 36
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 37
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (2)..(2)
<223> Xaa is Ornithine with thiol modified Polyethylene glycole 5000 bound to iodoacetylated N-terminus of Gly-Ala-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 37
Xaa Xaa Asn Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 38
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 38
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 39
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 39
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 40
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 40
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 41
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with Gly-Ala-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 41
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 42
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with Polyethylene glycole 750 bound to N-terminus of Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 42
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 43
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with Polyethylene glycole 750 bound to N-terminus of Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 43
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 44
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with Polyethylene glycole 750 bound to N-terminus of Gly-Ala-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 44
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 45
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with with thiol modified Polyethylene glycole 750 bound to iodoacetylated N-terminus of Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 45
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 46
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with with thiol modified Polyethylene glycole 750 bound to iodoacetylated N-terminus of Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 46
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 47
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with with thiol modified Polyethylene glycole 750 bound to iodoacetylated N-terminus of Gly-Ala-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 47
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 48
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with with thiol modified Polyethylene glycole 5000 bound to iodoacetylated N-terminus of Gly-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 48
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu 

<210> 49
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with with thiol modified Polyethylene glycole 5000 bound to iodoacetylated N-terminus of Gly-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 49
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210> 50
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Artificial Peptide

<220>
<221> misc_feature
<222> (1)..(1)
<223> Xaa is N-Guanido-Ornithine

<220>
<221> misc_feature
<222> (3)..(3)
<223> Xaa is Ornithine with with thiol modified Polyethylene glycole 5000 bound to iodoacetylated N-terminus of Gly-Ala-Ala-Arg-Ser-Gly-Linker bound to delta-NH2 of Ornithine 

<400> 50
Xaa Asn Xaa Arg Pro Val Tyr Ile Pro Arg Pro Arg Pro Pro His Pro 
1               5                   10                   15    
Arg Leu

<210>  51
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is Ornithine

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is Ornithine amide

<400>  51
Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Arg Xaa Ile 
1               5                   10                  15      
Tyr Asn Xaa

<210>  52
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is tert-Leucine 

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is Ornithine amide

<400>  52
Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Xaa Arg Xaa Xaa 
1               5                   10                  15      
Tyr Asn Xaa

<210>  53
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is Ornithine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is Ornithine amide

<400>  53
Gly Ala Arg Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro  
1               5                   10                  15      
Arg Xaa Ile Tyr Asn Xaa
            20
<210>  54
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is tert-Leucine 

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is Ornithine amide

<400>  54
Gly Ala Arg Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Xaa  
1               5                   10                  15      
Arg Xaa Xaa Tyr Asn Xaa
            20

<210>  55
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is glycine with Polyethylene glycole 750 bound to N-terminus

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is Ornithine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is Ornithine amide

<400>  55
Xaa Ala Arg Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro  
1               5                   10                  15      
Arg Xaa Ile Tyr Asn Xaa
            20
<210>  56
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is glycine with Polyethylene glycole 750 bound to N-terminus

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is tert-Leucine 

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is Ornithine amide

<400>  56
Xaa Ala Arg Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Xaa  
1               5                   10                  15      
Arg Xaa Xaa Tyr Asn Xaa
            20

<210>  57
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is glycine with thiol modified Polyethylene glycole 750 bound to iodoacetylated N-terminus 

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is Ornithine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is Ornithine amide

<400>  57
Xaa Ala Arg Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro  
1               5                   10                  15      
Arg Xaa Ile Tyr Asn Xaa
            20
<210>  58
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is glycine with thiol modified Polyethylene glycole 750 bound to iodoacetylated N-terminus 

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is tert-Leucine 

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is Ornithine amide

<400>  58
Xaa Ala Arg Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Xaa  
1               5                   10                  15      
Arg Xaa Xaa Tyr Asn Xaa
            20

<210>  59
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is glycine with thiol modified Polyethylene glycole 5000 bound to iodoacetylated N-terminus 

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is Ornithine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is Ornithine amide

<400>  59
Xaa Ala Arg Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro  
1               5                   10                  15      
Arg Xaa Ile Tyr Asn Xaa
            20
<210>  60
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Peptide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is glycine with thiol modified Polyethylene glycole 5000 bound to iodoacetylated N-terminus 

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa is 4-Hydroxyproline

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is tert-Leucine 

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa is Ornithine amide

<400>  60
Xaa Ala Arg Val Asp Lys Pro Pro Tyr Leu Pro Arg Pro Arg Pro Xaa  
1               5                   10                  15      
Arg Xaa Xaa Tyr Asn Xaa
            20

<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<400>  61

Gly Arg Ser Gly

<210>  62
<211>  22
<212>  PRT
<213>  Artificial Sequence

<400>  62

Gly Ala Arg Ser Gly
                5

<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<400>  63

Gly Ala Ala Arg Ser Gly

<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  64

Gly Ala Ala Ala Arg Ser Gly
                5

<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<400>  65

Gly Ala Ala Ala Ala Arg Ser Gly
                5

<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<400>  66

Gly Ala Ala Arg               