                         SEQUENCE LISTING

<110>  Dale, James B.

<110>  University of Tennessee Research Foundation 
 
<120>  GROUP A STREPTOCOCCUS MULTIVALENT VACCINE

<130>  920098.414PC

<150>  61/498,397
<151>  2011-06-17

<150>  61/641,448
<151>  2012-05-02

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  1

Asn Gly Asp Gly Asn Pro Arg Glu Val Ile Glu Asp Leu Ala Ala Asn 
1               5                   10                  15      


Asn Pro Ala Ile Gln Asn Ile Arg Leu Arg His Glu Asn Lys Asp Leu 
            20                  25                  30          


Lys Ala Arg Leu Glu Asn Ala Met Glu Val Ala Gly Arg Asp Phe Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Gln Val Thr Gln Leu Tyr Thr Lys His Asn Ser 
    50                  55                  60                  


Asn Tyr Gln Gln Tyr Asn Ala Gln Ala Gly Arg Leu Asp Leu Arg Gln 
65                  70                  75                  80  


Lys Ala Glu Tyr Leu Lys Gly Leu Asn Asp Trp Ala Glu Arg Leu Leu 
                85                  90                  95      


Gln Glu Leu Asn Arg Val Phe Pro Arg Gly Thr Val Glu Asn Pro Asp 
            100                 105                 110         


Lys Ala Arg Glu Leu Leu Asn Lys Tyr Asp Val Glu Asn Arg Val Phe 
        115                 120                 125             


Pro Arg Gly Thr Val Glu Asn Pro Asp Lys Ala Arg Glu Leu Leu Asn 
    130                 135                 140                 


Lys Tyr Asp Val Glu Asn Ser Lys Asn Pro Val Pro Val Lys Lys Glu 
145                 150                 155                 160 


Ala Lys Leu Ser Glu Ala Glu Leu His Asp Lys Ile Lys Asn Leu Ser 
                165                 170                 175     


Lys Asn Pro Val Pro Val Lys Lys Glu Ala Lys Leu Ser Glu Ala Glu 
            180                 185                 190         


Leu His Asp Lys Ile Lys Asn Leu Ala Pro Leu Thr Arg Ala Thr Ala 
        195                 200                 205             


Asp Asn Lys Asp Glu Leu Ile Lys Arg Ala Asn Asp Tyr Glu Ile Gln 
    210                 215                 220                 


Asn His Gln Leu Thr Val Glu Asn Lys Lys Leu Lys Thr Asp Lys Glu 
225                 230                 235                 240 


Gln Leu Thr Lys Glu Asn Asp Asp Leu Lys Ala Glu Ser Pro Lys Ser 
                245                 250                 255     


Thr Glu Thr Ser Ala Asn Gly Ala Asp Lys Leu Ala Asp Ala Tyr Asn 
            260                 265                 270         


Thr Leu Leu Thr Glu His Glu Lys Leu Arg Asp Glu Tyr Tyr Thr Leu 
        275                 280                 285             


Ile Asp Ala Lys Glu Glu Glu Pro Arg Tyr Lys Ala Asp His Ser Asp 
    290                 295                 300                 


Leu Val Ala Glu Lys Gln Arg Leu Glu Asp Leu Gly Gln Lys Phe Glu 
305                 310                 315                 320 


Arg Leu Lys Gln Arg Ser Glu Leu Tyr Leu Gln Gln Tyr Tyr Asp Asn 
                325                 330                 335     


Lys Ser Asn Gly Tyr Lys Gly Asp Trp Tyr Val Gln Gln Leu Asp Ser 
            340                 345                 350         


Val Ser Gly Leu Glu Val Ala Asp Pro Ser Asp Ser Lys Lys Leu Ile 
        355                 360                 365             


Glu Leu Gly Leu Ala Lys Tyr Leu Asn Asp Lys Leu Pro Phe Lys Thr 
    370                 375                 380                 


Lys Glu Asp Ser Glu Ile Leu Ser Glu Leu Arg Asp Val Leu Lys Asn 
385                 390                 395                 400 


Asn Gly Asp Gly Asn Pro Arg Glu Val Ile Glu Asp Leu Ala Ala Asn 
                405                 410                 415     


Asn Pro Ala Ile Gln Asn Ile Arg Leu Arg His Glu Asn Lys Asp Leu 
            420                 425                 430         


Lys Ala Arg Leu Glu Asn Ala Met Glu Val Ala Gly Arg Asp Phe Lys 
        435                 440                 445             


Arg Ala 
    450 


<210>  2
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  2

Ala Glu Ile Lys Lys Pro Gln Ala Asp Ser Ala Trp Asn Trp Pro Lys 
1               5                   10                  15      


Glu Tyr Asn Ala Leu Leu Lys Glu Asn Glu Glu Leu Lys Val Glu Arg 
            20                  25                  30          


Glu Lys Tyr Leu Ser Tyr Ala Asp Asp Lys Glu Lys Asp Pro Gln Tyr 
        35                  40                  45              


Arg Ala Ala Val Thr Arg Gly Thr Ile Asn Asp Pro Gln Arg Ala Lys 
    50                  55                  60                  


Glu Ala Leu Asp Lys Tyr Glu Leu Glu Asn His Ala Val Thr Arg Gly 
65                  70                  75                  80  


Thr Ile Asn Asp Pro Gln Arg Ala Lys Glu Ala Leu Asp Lys Tyr Glu 
                85                  90                  95      


Leu Glu Asn His Thr Glu Val Lys Ala Ala Gly Gln Ser Ala Pro Lys 
            100                 105                 110         


Gly Thr Asn Val Ser Ala Asp Leu Tyr Asn Ser Leu Trp Asp Glu Asn 
        115                 120                 125             


Lys Thr Leu Arg Glu Lys Gln Glu Glu Tyr Ile Thr Lys Ile Gln Asn 
    130                 135                 140                 


Glu Glu Thr Lys Asn Lys Glu Glu Glu Arg Thr Phe Thr Glu Leu Pro 
145                 150                 155                 160 


Tyr Glu Ala Arg Tyr Lys Ala Trp Lys Ser Glu Asn Asp Glu Leu Arg 
                165                 170                 175     


Glu Asn Tyr Arg Arg Thr Leu Asp Lys Phe Asn Thr Glu Gln Gly Lys 
            180                 185                 190         


Thr Thr Arg Leu Glu Glu Gln Asn Arg Val Arg Tyr Thr Arg His Thr 
        195                 200                 205             


Pro Glu Asp Lys Leu Lys Lys Ile Ile Asp Asp Leu Asp Ala Lys Glu 
    210                 215                 220                 


His Arg Val Arg Tyr Thr Arg His Thr Pro Glu Asp Lys Leu Lys Lys 
225                 230                 235                 240 


Ile Ile Asp Asp Leu Asp Ala Lys Glu His Arg Val Tyr Ile Thr Arg 
                245                 250                 255     


Arg Met Thr Lys Glu Asp Val Glu Lys Ile Ala Asn Asp Leu Asp Thr 
            260                 265                 270         


Glu Asn His Gly Leu Lys Gln Gln Asn Glu Gln Leu Ser Thr Glu Lys 
        275                 280                 285             


Gln Gly Leu Glu Glu Gln Asn Lys Gln Leu Ser Thr Asp Arg Val Ser 
    290                 295                 300                 


Arg Ser Met Ser Arg Asp Asp Leu Leu Asn Arg Ala Gln Asp Leu Glu 
305                 310                 315                 320 


Ala Lys Asn His Gly Leu Glu His Gln Asn Thr Lys Leu Ser Thr Glu 
                325                 330                 335     


Asn Lys Thr Leu Gln Glu Gln Ala Glu Ala Arg Gln Lys Glu Val Ala 
            340                 345                 350         


Thr Arg Ser Gln Thr Asp Thr Leu Glu Lys Val Gln Glu Arg Ala Asp 
        355                 360                 365             


Lys Phe Glu Ile Glu Asn Asn Thr Leu Lys Leu Lys Asn Ser Asp Leu 
    370                 375                 380                 


Ser Phe Asn Asn Lys Ala Leu Lys Asp His Asn Asp Glu Leu Thr Glu 
385                 390                 395                 400 


Ala Glu Ile Lys Lys Pro Gln Ala Asp Ser Ala Trp Asn Trp Pro Lys 
                405                 410                 415     


Glu Tyr Asn Ala Leu Leu Lys Glu Asn Glu Glu Leu Lys Val Glu Arg 
            420                 425                 430         


Glu Lys Tyr Leu Ser Tyr Ala Asp Asp Lys Glu Lys Asp Pro Gln Tyr 
        435                 440                 445             


Arg Ala 
    450 


<210>  3
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  3

Glu Gly Val Ser Val Gly Ser Asp Ala Ser Leu His Asn Arg Ile Thr 
1               5                   10                  15      


Asp Leu Glu Glu Glu Arg Glu Lys Leu Leu Asn Lys Leu Asp Lys Val 
            20                  25                  30          


Glu Glu Glu His Lys Lys Asp His Glu Gln Leu Glu Lys Lys Ser Glu 
        35                  40                  45              


Asp Val Glu Ser Ser Asn Asn Ala Glu Ser Ser Asn Ile Ser Gln Glu 
    50                  55                  60                  


Ser Lys Leu Ile Asn Thr Leu Thr Asp Glu Asn Glu Lys Leu Arg Glu 
65                  70                  75                  80  


Glu Leu Gln Gln Tyr Tyr Ala Leu Ser Asp Ala Lys Glu Glu Glu Pro 
                85                  90                  95      


Arg Tyr Lys Ala Asp Asn Gln Ser Pro Ala Pro Val Lys Lys Glu Ala 
            100                 105                 110         


Lys Lys Leu Asn Glu Ala Glu Leu Tyr Asn Lys Ile Gln Glu Leu Glu 
        115                 120                 125             


Glu Gly Lys Ala Glu Leu Phe Asp Lys Leu Glu Lys Val Glu Glu Glu 
    130                 135                 140                 


Asn Lys Lys Val Lys Glu Asp Ser Asp Asn Ile Asn Arg Ser Val Ser 
145                 150                 155                 160 


Val Lys Asp Asn Glu Lys Glu Leu His Asn Lys Ile Ala Asp Leu Glu 
                165                 170                 175     


Glu Glu Arg Gly Glu His Leu Asp Lys Ile Asp Glu Leu Lys Glu Glu 
            180                 185                 190         


Leu Lys Ala Lys Glu Lys Ser Ser Asp Ser Ser Arg Glu Val Thr Asn 
        195                 200                 205             


Glu Leu Thr Ala Ser Met Trp Lys Ala Gln Ala Asp Ser Ala Lys Ala 
    210                 215                 220                 


Lys Ala Lys Glu Leu Glu Lys Gln Val Glu Glu Tyr Lys Lys Asn Tyr 
225                 230                 235                 240 


Glu Thr Leu Glu Lys Gly Tyr Asp Asp Leu Ala Glu Ser Arg Ser Val 
                245                 250                 255     


Ser Gln Gly Ser Val Ser Leu Glu Leu Tyr Asp Lys Leu Ser Asp Glu 
            260                 265                 270         


Asn Asp Ile Leu Arg Glu Lys Gln Asp Glu Tyr Leu Thr Lys Ile Asp 
        275                 280                 285             


Gly Leu Asp Lys Glu Asn Lys Glu Tyr Ala Ser Gln Glu Ser Gln Asn 
    290                 295                 300                 


Ser Arg Ser Ile Thr Asn Glu Gln Leu Ile Asp Lys Leu Val Glu Glu 
305                 310                 315                 320 


Asn Asn Asp Leu Lys Glu Glu Arg Ala Lys Tyr Leu Asp Leu Leu Asp 
                325                 330                 335     


Asn Arg Glu Lys Asp Pro Gln Tyr Arg Ala Leu Met Gly Glu Ala Glu 
            340                 345                 350         


Lys Lys Val Glu Val Ala Asp Ser Asn Ala Ser Ser Val Ala Lys Leu 
        355                 360                 365             


Tyr Asn Gln Ile Ala Asp Leu Thr Asp Lys Asn Gly Glu Tyr Leu Glu 
    370                 375                 380                 


Arg Ile Glu Glu Leu Glu Glu Arg Gln Lys Asn Leu Glu Lys Leu Glu 
385                 390                 395                 400 


Glu Gly Val Ser Val Gly Ser Asp Ala Ser Leu His Asn Arg Ile Thr 
                405                 410                 415     


Asp Leu Glu Glu Glu Arg Glu Lys Leu Leu Asn Lys Leu Asp Lys Val 
            420                 425                 430         


Glu Glu Glu His Lys Lys Asp His Glu Gln Leu Glu Lys Lys Ser Glu 
        435                 440                 445             


Asp Val 
    450 


<210>  4
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  4

Asp Asn Pro Arg Tyr Thr Asp Ala His Asn Ala Val Thr Gln Gly Arg 
1               5                   10                  15      


Thr Val Pro Leu Gln Asn Leu Leu His Glu Met Asp Lys Asn Gly Lys 
            20                  25                  30          


Leu Arg Ser Glu Asn Glu Glu Leu Lys Ala Asp Leu Gln Lys Lys Glu 
        35                  40                  45              


Gln Glu Asp Ser Ser Ser Arg Asp Ile Thr Glu Ala Gly Val Ser Lys 
    50                  55                  60                  


Phe Trp Lys Ser Lys Phe Asp Ala Glu Gln Asn Arg Ala Asn Glu Leu 
65                  70                  75                  80  


Glu Lys Lys Leu Ser Gly Tyr Glu Lys Asp Tyr Lys Thr Leu Glu Gln 
                85                  90                  95      


Glu Tyr Glu Asn Ala Gly Ser Glu Glu Asn Val Pro Lys Gln Gln Tyr 
            100                 105                 110         


Asn Ala Leu Trp Glu Glu Asn Glu Asp Leu Arg Gly Arg Glu Arg Lys 
        115                 120                 125             


Tyr Ile Ala Lys Leu Glu Lys Glu Glu Ile Gln Asn Gly Glu Leu Asn 
    130                 135                 140                 


Glu Lys Asn Arg Lys Leu Glu Ser Pro Arg Glu Val Thr Asn Glu Leu 
145                 150                 155                 160 


Ala Ala Ser Val Trp Lys Lys Lys Val Glu Glu Ala Lys Glu Lys Ala 
                165                 170                 175     


Ser Lys Leu Glu Lys Gln Leu Glu Glu Ala Gln Lys Asp Tyr Ser Glu 
            180                 185                 190         


Ile Glu Gly Lys Leu Glu Gln Phe Val Glu Lys Lys Val Glu Ala Ala 
        195                 200                 205             


Glu Asn Asn Val Ser Ser Val Ala Arg Arg Glu Lys Glu Leu Tyr Asp 
    210                 215                 220                 


Gln Ile Ala Asp Leu Thr Asp Lys Asn Gly Glu Tyr Leu Glu Arg Ile 
225                 230                 235                 240 


Gly Glu Leu Glu Glu Arg Gln Lys Asn Leu Asp Asp Arg Ser Val Ser 
                245                 250                 255     


Thr Asn Ser Gly Ser Val Ser Thr Pro Tyr Asn Asn Leu Leu Asn Glu 
            260                 265                 270         


Tyr Asp Asp Leu Leu Ala Lys His Gly Glu Leu Leu Ser Glu Tyr Asp 
        275                 280                 285             


Ala Leu Lys Glu Lys Gln Asp Lys Asn Gln Glu Glu Asn Ser Lys Asn 
    290                 295                 300                 


Pro Ala Pro Ala Pro Ala Ser Ala Val Pro Val Lys Lys Glu Ala Thr 
305                 310                 315                 320 


Lys Leu Ser Glu Ala Glu Leu Tyr Asn Lys Ile Gln Glu Leu Glu Glu 
                325                 330                 335     


Gly Lys Ala Glu Leu Phe Asp Lys Leu Glu Lys Val Glu Glu Asp Asn 
            340                 345                 350         


Pro Arg Tyr Thr Asp Ala His Asn Ala Val Thr Gln Gly Arg Thr Val 
        355                 360                 365             


Pro Leu Gln Asn Leu Leu His Glu Met Asp Lys Asn Gly Lys Leu Arg 
    370                 375                 380                 


Ser Glu Asn Glu Glu Leu Lys Ala Asp Leu Gln Lys Lys Glu Gln Glu 
385                 390                 395                 400 


<210>  5
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  5

Met Asn Gly Asp Gly Asn Pro Arg Glu Val Ile Glu Asp Leu Ala Ala 
1               5                   10                  15      


Asn Asn Pro Ala Ile Gln Asn Ile Arg Leu Arg His Glu Asn Lys Asp 
            20                  25                  30          


Leu Lys Ala Arg Leu Glu Asn Ala Met Glu Val Ala Gly Arg Asp Phe 
        35                  40                  45              


Lys Arg Ala Leu Leu Asp Gln Val Thr Gln Leu Tyr Thr Lys His Asn 
    50                  55                  60                  


Ser Asn Tyr Gln Gln Tyr Asn Ala Gln Ala Gly Arg Leu Asp Leu Arg 
65                  70                  75                  80  


Gln Lys Ala Glu Tyr Leu Lys Gly Leu Asn Asp Trp Ala Glu Arg Leu 
                85                  90                  95      


Leu Gln Glu Leu Asn Arg Val Phe Pro Arg Gly Thr Val Glu Asn Pro 
            100                 105                 110         


Asp Lys Ala Arg Glu Leu Leu Asn Lys Tyr Asp Val Glu Asn Arg Val 
        115                 120                 125             


Phe Pro Arg Gly Thr Val Glu Asn Pro Asp Lys Ala Arg Glu Leu Leu 
    130                 135                 140                 


Asn Lys Tyr Asp Val Glu Asn Ser Lys Asn Pro Val Pro Val Lys Lys 
145                 150                 155                 160 


Glu Ala Lys Leu Ser Glu Ala Glu Leu His Asp Lys Ile Lys Asn Leu 
                165                 170                 175     


Ser Lys Asn Pro Val Pro Val Lys Lys Glu Ala Lys Leu Ser Glu Ala 
            180                 185                 190         


Glu Leu His Asp Lys Ile Lys Asn Leu Ala Pro Leu Thr Arg Ala Thr 
        195                 200                 205             


Ala Asp Asn Lys Asp Glu Leu Ile Lys Arg Ala Asn Asp Tyr Glu Ile 
    210                 215                 220                 


Gln Asn His Gln Leu Thr Val Glu Asn Lys Lys Leu Lys Thr Asp Lys 
225                 230                 235                 240 


Glu Gln Leu Thr Lys Glu Asn Asp Asp Leu Lys Ala Glu Ser Pro Lys 
                245                 250                 255     


Ser Thr Glu Thr Ser Ala Asn Gly Ala Asp Lys Leu Ala Asp Ala Tyr 
            260                 265                 270         


Asn Thr Leu Leu Thr Glu His Glu Lys Leu Arg Asp Glu Tyr Tyr Thr 
        275                 280                 285             


Leu Ile Asp Ala Lys Glu Glu Glu Pro Arg Tyr Lys Ala Asp His Ser 
    290                 295                 300                 


Asp Leu Val Ala Glu Lys Gln Arg Leu Glu Asp Leu Gly Gln Lys Phe 
305                 310                 315                 320 


Glu Arg Leu Lys Gln Arg Ser Glu Leu Tyr Leu Gln Gln Tyr Tyr Asp 
                325                 330                 335     


Asn Lys Ser Asn Gly Tyr Lys Gly Asp Trp Tyr Val Gln Gln Leu Asp 
            340                 345                 350         


Ser Val Ser Gly Leu Glu Val Ala Asp Pro Ser Asp Ser Lys Lys Leu 
        355                 360                 365             


Ile Glu Leu Gly Leu Ala Lys Tyr Leu Asn Asp Lys Leu Pro Phe Lys 
    370                 375                 380                 


Thr Lys Glu Asp Ser Glu Ile Leu Ser Glu Leu Arg Asp Val Leu Lys 
385                 390                 395                 400 


Asn Asn Gly Asp Gly Asn Pro Arg Glu Val Ile Glu Asp Leu Ala Ala 
                405                 410                 415     


Asn Asn Pro Ala Ile Gln Asn Ile Arg Leu Arg His Glu Asn Lys Asp 
            420                 425                 430         


Leu Lys Ala Arg Leu Glu Asn Ala Met Glu Val Ala Gly Arg Asp Phe 
        435                 440                 445             


Lys Arg Ala 
    450     


<210>  6
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  6

Met Ala Glu Ile Lys Lys Pro Gln Ala Asp Ser Ala Trp Asn Trp Pro 
1               5                   10                  15      


Lys Glu Tyr Asn Ala Leu Leu Lys Glu Asn Glu Glu Leu Lys Val Glu 
            20                  25                  30          


Arg Glu Lys Tyr Leu Ser Tyr Ala Asp Asp Lys Glu Lys Asp Pro Gln 
        35                  40                  45              


Tyr Arg Ala Ala Val Thr Arg Gly Thr Ile Asn Asp Pro Gln Arg Ala 
    50                  55                  60                  


Lys Glu Ala Leu Asp Lys Tyr Glu Leu Glu Asn His Ala Val Thr Arg 
65                  70                  75                  80  


Gly Thr Ile Asn Asp Pro Gln Arg Ala Lys Glu Ala Leu Asp Lys Tyr 
                85                  90                  95      


Glu Leu Glu Asn His Thr Glu Val Lys Ala Ala Gly Gln Ser Ala Pro 
            100                 105                 110         


Lys Gly Thr Asn Val Ser Ala Asp Leu Tyr Asn Ser Leu Trp Asp Glu 
        115                 120                 125             


Asn Lys Thr Leu Arg Glu Lys Gln Glu Glu Tyr Ile Thr Lys Ile Gln 
    130                 135                 140                 


Asn Glu Glu Thr Lys Asn Lys Glu Glu Glu Arg Thr Phe Thr Glu Leu 
145                 150                 155                 160 


Pro Tyr Glu Ala Arg Tyr Lys Ala Trp Lys Ser Glu Asn Asp Glu Leu 
                165                 170                 175     


Arg Glu Asn Tyr Arg Arg Thr Leu Asp Lys Phe Asn Thr Glu Gln Gly 
            180                 185                 190         


Lys Thr Thr Arg Leu Glu Glu Gln Asn Arg Val Arg Tyr Thr Arg His 
        195                 200                 205             


Thr Pro Glu Asp Lys Leu Lys Lys Ile Ile Asp Asp Leu Asp Ala Lys 
    210                 215                 220                 


Glu His Arg Val Arg Tyr Thr Arg His Thr Pro Glu Asp Lys Leu Lys 
225                 230                 235                 240 


Lys Ile Ile Asp Asp Leu Asp Ala Lys Glu His Arg Val Tyr Ile Thr 
                245                 250                 255     


Arg Arg Met Thr Lys Glu Asp Val Glu Lys Ile Ala Asn Asp Leu Asp 
            260                 265                 270         


Thr Glu Asn His Gly Leu Lys Gln Gln Asn Glu Gln Leu Ser Thr Glu 
        275                 280                 285             


Lys Gln Gly Leu Glu Glu Gln Asn Lys Gln Leu Ser Thr Asp Arg Val 
    290                 295                 300                 


Ser Arg Ser Met Ser Arg Asp Asp Leu Leu Asn Arg Ala Gln Asp Leu 
305                 310                 315                 320 


Glu Ala Lys Asn His Gly Leu Glu His Gln Asn Thr Lys Leu Ser Thr 
                325                 330                 335     


Glu Asn Lys Thr Leu Gln Glu Gln Ala Glu Ala Arg Gln Lys Glu Val 
            340                 345                 350         


Ala Thr Arg Ser Gln Thr Asp Thr Leu Glu Lys Val Gln Glu Arg Ala 
        355                 360                 365             


Asp Lys Phe Glu Ile Glu Asn Asn Thr Leu Lys Leu Lys Asn Ser Asp 
    370                 375                 380                 


Leu Ser Phe Asn Asn Lys Ala Leu Lys Asp His Asn Asp Glu Leu Thr 
385                 390                 395                 400 


Glu Ala Glu Ile Lys Lys Pro Gln Ala Asp Ser Ala Trp Asn Trp Pro 
                405                 410                 415     


Lys Glu Tyr Asn Ala Leu Leu Lys Glu Asn Glu Glu Leu Lys Val Glu 
            420                 425                 430         


Arg Glu Lys Tyr Leu Ser Tyr Ala Asp Asp Lys Glu Lys Asp Pro Gln 
        435                 440                 445             


Tyr Arg Ala 
    450     


<210>  7
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  7

Met Glu Gly Val Ser Val Gly Ser Asp Ala Ser Leu His Asn Arg Ile 
1               5                   10                  15      


Thr Asp Leu Glu Glu Glu Arg Glu Lys Leu Leu Asn Lys Leu Asp Lys 
            20                  25                  30          


Val Glu Glu Glu His Lys Lys Asp His Glu Gln Leu Glu Lys Lys Ser 
        35                  40                  45              


Glu Asp Val Glu Ser Ser Asn Asn Ala Glu Ser Ser Asn Ile Ser Gln 
    50                  55                  60                  


Glu Ser Lys Leu Ile Asn Thr Leu Thr Asp Glu Asn Glu Lys Leu Arg 
65                  70                  75                  80  


Glu Glu Leu Gln Gln Tyr Tyr Ala Leu Ser Asp Ala Lys Glu Glu Glu 
                85                  90                  95      


Pro Arg Tyr Lys Ala Asp Asn Gln Ser Pro Ala Pro Val Lys Lys Glu 
            100                 105                 110         


Ala Lys Lys Leu Asn Glu Ala Glu Leu Tyr Asn Lys Ile Gln Glu Leu 
        115                 120                 125             


Glu Glu Gly Lys Ala Glu Leu Phe Asp Lys Leu Glu Lys Val Glu Glu 
    130                 135                 140                 


Glu Asn Lys Lys Val Lys Glu Asp Ser Asp Asn Ile Asn Arg Ser Val 
145                 150                 155                 160 


Ser Val Lys Asp Asn Glu Lys Glu Leu His Asn Lys Ile Ala Asp Leu 
                165                 170                 175     


Glu Glu Glu Arg Gly Glu His Leu Asp Lys Ile Asp Glu Leu Lys Glu 
            180                 185                 190         


Glu Leu Lys Ala Lys Glu Lys Ser Ser Asp Ser Ser Arg Glu Val Thr 
        195                 200                 205             


Asn Glu Leu Thr Ala Ser Met Trp Lys Ala Gln Ala Asp Ser Ala Lys 
    210                 215                 220                 


Ala Lys Ala Lys Glu Leu Glu Lys Gln Val Glu Glu Tyr Lys Lys Asn 
225                 230                 235                 240 


Tyr Glu Thr Leu Glu Lys Gly Tyr Asp Asp Leu Ala Glu Ser Arg Ser 
                245                 250                 255     


Val Ser Gln Gly Ser Val Ser Leu Glu Leu Tyr Asp Lys Leu Ser Asp 
            260                 265                 270         


Glu Asn Asp Ile Leu Arg Glu Lys Gln Asp Glu Tyr Leu Thr Lys Ile 
        275                 280                 285             


Asp Gly Leu Asp Lys Glu Asn Lys Glu Tyr Ala Ser Gln Glu Ser Gln 
    290                 295                 300                 


Asn Ser Arg Ser Ile Thr Asn Glu Gln Leu Ile Asp Lys Leu Val Glu 
305                 310                 315                 320 


Glu Asn Asn Asp Leu Lys Glu Glu Arg Ala Lys Tyr Leu Asp Leu Leu 
                325                 330                 335     


Asp Asn Arg Glu Lys Asp Pro Gln Tyr Arg Ala Leu Met Gly Glu Ala 
            340                 345                 350         


Glu Lys Lys Val Glu Val Ala Asp Ser Asn Ala Ser Ser Val Ala Lys 
        355                 360                 365             


Leu Tyr Asn Gln Ile Ala Asp Leu Thr Asp Lys Asn Gly Glu Tyr Leu 
    370                 375                 380                 


Glu Arg Ile Glu Glu Leu Glu Glu Arg Gln Lys Asn Leu Glu Lys Leu 
385                 390                 395                 400 


Glu Glu Gly Val Ser Val Gly Ser Asp Ala Ser Leu His Asn Arg Ile 
                405                 410                 415     


Thr Asp Leu Glu Glu Glu Arg Glu Lys Leu Leu Asn Lys Leu Asp Lys 
            420                 425                 430         


Val Glu Glu Glu His Lys Lys Asp His Glu Gln Leu Glu Lys Lys Ser 
        435                 440                 445             


Glu Asp Val 
    450     


<210>  8
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  8

Met Asp Asn Pro Arg Tyr Thr Asp Ala His Asn Ala Val Thr Gln Gly 
1               5                   10                  15      


Arg Thr Val Pro Leu Gln Asn Leu Leu His Glu Met Asp Lys Asn Gly 
            20                  25                  30          


Lys Leu Arg Ser Glu Asn Glu Glu Leu Lys Ala Asp Leu Gln Lys Lys 
        35                  40                  45              


Glu Gln Glu Asp Ser Ser Ser Arg Asp Ile Thr Glu Ala Gly Val Ser 
    50                  55                  60                  


Lys Phe Trp Lys Ser Lys Phe Asp Ala Glu Gln Asn Arg Ala Asn Glu 
65                  70                  75                  80  


Leu Glu Lys Lys Leu Ser Gly Tyr Glu Lys Asp Tyr Lys Thr Leu Glu 
                85                  90                  95      


Gln Glu Tyr Glu Asn Ala Gly Ser Glu Glu Asn Val Pro Lys Gln Gln 
            100                 105                 110         


Tyr Asn Ala Leu Trp Glu Glu Asn Glu Asp Leu Arg Gly Arg Glu Arg 
        115                 120                 125             


Lys Tyr Ile Ala Lys Leu Glu Lys Glu Glu Ile Gln Asn Gly Glu Leu 
    130                 135                 140                 


Asn Glu Lys Asn Arg Lys Leu Glu Ser Pro Arg Glu Val Thr Asn Glu 
145                 150                 155                 160 


Leu Ala Ala Ser Val Trp Lys Lys Lys Val Glu Glu Ala Lys Glu Lys 
                165                 170                 175     


Ala Ser Lys Leu Glu Lys Gln Leu Glu Glu Ala Gln Lys Asp Tyr Ser 
            180                 185                 190         


Glu Ile Glu Gly Lys Leu Glu Gln Phe Val Glu Lys Lys Val Glu Ala 
        195                 200                 205             


Ala Glu Asn Asn Val Ser Ser Val Ala Arg Arg Glu Lys Glu Leu Tyr 
    210                 215                 220                 


Asp Gln Ile Ala Asp Leu Thr Asp Lys Asn Gly Glu Tyr Leu Glu Arg 
225                 230                 235                 240 


Ile Gly Glu Leu Glu Glu Arg Gln Lys Asn Leu Asp Asp Arg Ser Val 
                245                 250                 255     


Ser Thr Asn Ser Gly Ser Val Ser Thr Pro Tyr Asn Asn Leu Leu Asn 
            260                 265                 270         


Glu Tyr Asp Asp Leu Leu Ala Lys His Gly Glu Leu Leu Ser Glu Tyr 
        275                 280                 285             


Asp Ala Leu Lys Glu Lys Gln Asp Lys Asn Gln Glu Glu Asn Ser Lys 
    290                 295                 300                 


Asn Pro Ala Pro Ala Pro Ala Ser Ala Val Pro Val Lys Lys Glu Ala 
305                 310                 315                 320 


Thr Lys Leu Ser Glu Ala Glu Leu Tyr Asn Lys Ile Gln Glu Leu Glu 
                325                 330                 335     


Glu Gly Lys Ala Glu Leu Phe Asp Lys Leu Glu Lys Val Glu Glu Asp 
            340                 345                 350         


Asn Pro Arg Tyr Thr Asp Ala His Asn Ala Val Thr Gln Gly Arg Thr 
        355                 360                 365             


Val Pro Leu Gln Asn Leu Leu His Glu Met Asp Lys Asn Gly Lys Leu 
    370                 375                 380                 


Arg Ser Glu Asn Glu Glu Leu Lys Ala Asp Leu Gln Lys Lys Glu Gln 
385                 390                 395                 400 


Glu 
    


<210>  9
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  9

Met Asn Gly Asp Gly Asn Pro Arg Glu Val Ile Glu Asp Leu Ala Ala 
1               5                   10                  15      


Asn Asn Pro Ala Ile Gln Asn Ile Arg Leu Arg His Glu Asn Lys Asp 
            20                  25                  30          


Leu Lys Ala Arg Leu Glu Asn Ala Met Glu Val Ala Gly Arg Asp Phe 
        35                  40                  45              


Lys Arg Ala Leu Leu Asp Gln Val Thr Gln Leu Tyr Thr Lys His Asn 
    50                  55                  60                  


Ser Asn Tyr Gln Gln Tyr Asn Ala Gln Ala Gly Arg Leu Asp Leu Arg 
65                  70                  75                  80  


Gln Lys Ala Glu Tyr Leu Lys Gly Leu Asn Asp Trp Ala Glu Arg Leu 
                85                  90                  95      


Leu Gln Glu Leu Asn Arg Val Phe Pro Arg Gly Thr Val Glu Asn Pro 
            100                 105                 110         


Asp Lys Ala Arg Glu Leu Leu Asn Lys Tyr Asp Val Glu Asn Arg Val 
        115                 120                 125             


Phe Pro Arg Gly Thr Val Glu Asn Pro Asp Lys Ala Arg Glu Leu Leu 
    130                 135                 140                 


Asn Lys Tyr Asp Val Glu Asn Ser Lys Asn Pro Val Pro Val Lys Lys 
145                 150                 155                 160 


Glu Ala Lys Leu Ser Glu Ala Glu Leu His Asp Lys Ile Lys Asn Leu 
                165                 170                 175     


Ser Lys Asn Pro Val Pro Val Lys Lys Glu Ala Lys Leu Ser Glu Ala 
            180                 185                 190         


Glu Leu His Asp Lys Ile Lys Asn Leu Ala Pro Leu Thr Arg Ala Thr 
        195                 200                 205             


Ala Asp Asn Lys Asp Glu Leu Ile Lys Arg Ala Asn Asp Tyr Glu Ile 
    210                 215                 220                 


Gln Asn His Gln Leu Thr Val Glu Asn Lys Lys Leu Lys Thr Asp Lys 
225                 230                 235                 240 


Glu Gln Leu Thr Lys Glu Asn Asp Asp Leu Lys Ala Glu Ser Pro Lys 
                245                 250                 255     


Ser Thr Glu Thr Ser Ala Asn Gly Ala Asp Lys Leu Ala Asp Ala Tyr 
            260                 265                 270         


Asn Thr Leu Leu Thr Glu His Glu Lys Leu Arg Asp Glu Tyr Tyr Thr 
        275                 280                 285             


Leu Ile Asp Ala Lys Glu Glu Glu Pro Arg Tyr Lys Ala Asp His Ser 
    290                 295                 300                 


Asp Leu Val Ala Glu Lys Gln Arg Leu Glu Asp Leu Gly Gln Lys Phe 
305                 310                 315                 320 


Glu Arg Leu Lys Gln Arg Ser Glu Leu Tyr Leu Gln Gln Tyr Tyr Asp 
                325                 330                 335     


Asn Lys Ser Asn Gly Tyr Lys Gly Asp Trp Tyr Val Gln Gln Leu Asp 
            340                 345                 350         


Ser Val Ser Gly Leu Glu Val Ala Asp Pro Ser Asp Ser Lys Lys Leu 
        355                 360                 365             


Ile Glu Leu Gly Leu Ala Lys Tyr Leu Asn Asp Lys Leu Pro Phe Lys 
    370                 375                 380                 


Thr Lys Glu Asp Ser Glu Ile Leu Ser Glu Leu Arg Asp Val Leu Lys 
385                 390                 395                 400 


Asn Asn Gly Asp Gly Asn Pro Arg Glu Val Ile Glu Asp Leu Ala Ala 
                405                 410                 415     


Asn Asn Pro Ala Ile Gln Asn Ile Arg Leu Arg His Glu Asn Lys Asp 
            420                 425                 430         


Leu Lys Ala Arg Leu Glu Asn Ala Met Glu Val Ala Gly Arg Asp Phe 
        435                 440                 445             


Lys Arg Ala His His His His His His 
    450                 455         


<210>  10
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  10

Met Ala Glu Ile Lys Lys Pro Gln Ala Asp Ser Ala Trp Asn Trp Pro 
1               5                   10                  15      


Lys Glu Tyr Asn Ala Leu Leu Lys Glu Asn Glu Glu Leu Lys Val Glu 
            20                  25                  30          


Arg Glu Lys Tyr Leu Ser Tyr Ala Asp Asp Lys Glu Lys Asp Pro Gln 
        35                  40                  45              


Tyr Arg Ala Ala Val Thr Arg Gly Thr Ile Asn Asp Pro Gln Arg Ala 
    50                  55                  60                  


Lys Glu Ala Leu Asp Lys Tyr Glu Leu Glu Asn His Ala Val Thr Arg 
65                  70                  75                  80  


Gly Thr Ile Asn Asp Pro Gln Arg Ala Lys Glu Ala Leu Asp Lys Tyr 
                85                  90                  95      


Glu Leu Glu Asn His Thr Glu Val Lys Ala Ala Gly Gln Ser Ala Pro 
            100                 105                 110         


Lys Gly Thr Asn Val Ser Ala Asp Leu Tyr Asn Ser Leu Trp Asp Glu 
        115                 120                 125             


Asn Lys Thr Leu Arg Glu Lys Gln Glu Glu Tyr Ile Thr Lys Ile Gln 
    130                 135                 140                 


Asn Glu Glu Thr Lys Asn Lys Glu Glu Glu Arg Thr Phe Thr Glu Leu 
145                 150                 155                 160 


Pro Tyr Glu Ala Arg Tyr Lys Ala Trp Lys Ser Glu Asn Asp Glu Leu 
                165                 170                 175     


Arg Glu Asn Tyr Arg Arg Thr Leu Asp Lys Phe Asn Thr Glu Gln Gly 
            180                 185                 190         


Lys Thr Thr Arg Leu Glu Glu Gln Asn Arg Val Arg Tyr Thr Arg His 
        195                 200                 205             


Thr Pro Glu Asp Lys Leu Lys Lys Ile Ile Asp Asp Leu Asp Ala Lys 
    210                 215                 220                 


Glu His Arg Val Arg Tyr Thr Arg His Thr Pro Glu Asp Lys Leu Lys 
225                 230                 235                 240 


Lys Ile Ile Asp Asp Leu Asp Ala Lys Glu His Arg Val Tyr Ile Thr 
                245                 250                 255     


Arg Arg Met Thr Lys Glu Asp Val Glu Lys Ile Ala Asn Asp Leu Asp 
            260                 265                 270         


Thr Glu Asn His Gly Leu Lys Gln Gln Asn Glu Gln Leu Ser Thr Glu 
        275                 280                 285             


Lys Gln Gly Leu Glu Glu Gln Asn Lys Gln Leu Ser Thr Asp Arg Val 
    290                 295                 300                 


Ser Arg Ser Met Ser Arg Asp Asp Leu Leu Asn Arg Ala Gln Asp Leu 
305                 310                 315                 320 


Glu Ala Lys Asn His Gly Leu Glu His Gln Asn Thr Lys Leu Ser Thr 
                325                 330                 335     


Glu Asn Lys Thr Leu Gln Glu Gln Ala Glu Ala Arg Gln Lys Glu Val 
            340                 345                 350         


Ala Thr Arg Ser Gln Thr Asp Thr Leu Glu Lys Val Gln Glu Arg Ala 
        355                 360                 365             


Asp Lys Phe Glu Ile Glu Asn Asn Thr Leu Lys Leu Lys Asn Ser Asp 
    370                 375                 380                 


Leu Ser Phe Asn Asn Lys Ala Leu Lys Asp His Asn Asp Glu Leu Thr 
385                 390                 395                 400 


Glu Ala Glu Ile Lys Lys Pro Gln Ala Asp Ser Ala Trp Asn Trp Pro 
                405                 410                 415     


Lys Glu Tyr Asn Ala Leu Leu Lys Glu Asn Glu Glu Leu Lys Val Glu 
            420                 425                 430         


Arg Glu Lys Tyr Leu Ser Tyr Ala Asp Asp Lys Glu Lys Asp Pro Gln 
        435                 440                 445             


Tyr Arg Ala His His His His His His 
    450                 455         


<210>  11
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  11

Met Glu Gly Val Ser Val Gly Ser Asp Ala Ser Leu His Asn Arg Ile 
1               5                   10                  15      


Thr Asp Leu Glu Glu Glu Arg Glu Lys Leu Leu Asn Lys Leu Asp Lys 
            20                  25                  30          


Val Glu Glu Glu His Lys Lys Asp His Glu Gln Leu Glu Lys Lys Ser 
        35                  40                  45              


Glu Asp Val Glu Ser Ser Asn Asn Ala Glu Ser Ser Asn Ile Ser Gln 
    50                  55                  60                  


Glu Ser Lys Leu Ile Asn Thr Leu Thr Asp Glu Asn Glu Lys Leu Arg 
65                  70                  75                  80  


Glu Glu Leu Gln Gln Tyr Tyr Ala Leu Ser Asp Ala Lys Glu Glu Glu 
                85                  90                  95      


Pro Arg Tyr Lys Ala Asp Asn Gln Ser Pro Ala Pro Val Lys Lys Glu 
            100                 105                 110         


Ala Lys Lys Leu Asn Glu Ala Glu Leu Tyr Asn Lys Ile Gln Glu Leu 
        115                 120                 125             


Glu Glu Gly Lys Ala Glu Leu Phe Asp Lys Leu Glu Lys Val Glu Glu 
    130                 135                 140                 


Glu Asn Lys Lys Val Lys Glu Asp Ser Asp Asn Ile Asn Arg Ser Val 
145                 150                 155                 160 


Ser Val Lys Asp Asn Glu Lys Glu Leu His Asn Lys Ile Ala Asp Leu 
                165                 170                 175     


Glu Glu Glu Arg Gly Glu His Leu Asp Lys Ile Asp Glu Leu Lys Glu 
            180                 185                 190         


Glu Leu Lys Ala Lys Glu Lys Ser Ser Asp Ser Ser Arg Glu Val Thr 
        195                 200                 205             


Asn Glu Leu Thr Ala Ser Met Trp Lys Ala Gln Ala Asp Ser Ala Lys 
    210                 215                 220                 


Ala Lys Ala Lys Glu Leu Glu Lys Gln Val Glu Glu Tyr Lys Lys Asn 
225                 230                 235                 240 


Tyr Glu Thr Leu Glu Lys Gly Tyr Asp Asp Leu Ala Glu Ser Arg Ser 
                245                 250                 255     


Val Ser Gln Gly Ser Val Ser Leu Glu Leu Tyr Asp Lys Leu Ser Asp 
            260                 265                 270         


Glu Asn Asp Ile Leu Arg Glu Lys Gln Asp Glu Tyr Leu Thr Lys Ile 
        275                 280                 285             


Asp Gly Leu Asp Lys Glu Asn Lys Glu Tyr Ala Ser Gln Glu Ser Gln 
    290                 295                 300                 


Asn Ser Arg Ser Ile Thr Asn Glu Gln Leu Ile Asp Lys Leu Val Glu 
305                 310                 315                 320 


Glu Asn Asn Asp Leu Lys Glu Glu Arg Ala Lys Tyr Leu Asp Leu Leu 
                325                 330                 335     


Asp Asn Arg Glu Lys Asp Pro Gln Tyr Arg Ala Leu Met Gly Glu Ala 
            340                 345                 350         


Glu Lys Lys Val Glu Val Ala Asp Ser Asn Ala Ser Ser Val Ala Lys 
        355                 360                 365             


Leu Tyr Asn Gln Ile Ala Asp Leu Thr Asp Lys Asn Gly Glu Tyr Leu 
    370                 375                 380                 


Glu Arg Ile Glu Glu Leu Glu Glu Arg Gln Lys Asn Leu Glu Lys Leu 
385                 390                 395                 400 


Glu Glu Gly Val Ser Val Gly Ser Asp Ala Ser Leu His Asn Arg Ile 
                405                 410                 415     


Thr Asp Leu Glu Glu Glu Arg Glu Lys Leu Leu Asn Lys Leu Asp Lys 
            420                 425                 430         


Val Glu Glu Glu His Lys Lys Asp His Glu Gln Leu Glu Lys Lys Ser 
        435                 440                 445             


Glu Asp Val His His His His His His 
    450                 455         


<210>  12
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of group A streptococcus M proteins.

<400>  12

Met Asp Asn Pro Arg Tyr Thr Asp Ala His Asn Ala Val Thr Gln Gly 
1               5                   10                  15      


Arg Thr Val Pro Leu Gln Asn Leu Leu His Glu Met Asp Lys Asn Gly 
            20                  25                  30          


Lys Leu Arg Ser Glu Asn Glu Glu Leu Lys Ala Asp Leu Gln Lys Lys 
        35                  40                  45              


Glu Gln Glu Asp Ser Ser Ser Arg Asp Ile Thr Glu Ala Gly Val Ser 
    50                  55                  60                  


Lys Phe Trp Lys Ser Lys Phe Asp Ala Glu Gln Asn Arg Ala Asn Glu 
65                  70                  75                  80  


Leu Glu Lys Lys Leu Ser Gly Tyr Glu Lys Asp Tyr Lys Thr Leu Glu 
                85                  90                  95      


Gln Glu Tyr Glu Asn Ala Gly Ser Glu Glu Asn Val Pro Lys Gln Gln 
            100                 105                 110         


Tyr Asn Ala Leu Trp Glu Glu Asn Glu Asp Leu Arg Gly Arg Glu Arg 
        115                 120                 125             


Lys Tyr Ile Ala Lys Leu Glu Lys Glu Glu Ile Gln Asn Gly Glu Leu 
    130                 135                 140                 


Asn Glu Lys Asn Arg Lys Leu Glu Ser Pro Arg Glu Val Thr Asn Glu 
145                 150                 155                 160 


Leu Ala Ala Ser Val Trp Lys Lys Lys Val Glu Glu Ala Lys Glu Lys 
                165                 170                 175     


Ala Ser Lys Leu Glu Lys Gln Leu Glu Glu Ala Gln Lys Asp Tyr Ser 
            180                 185                 190         


Glu Ile Glu Gly Lys Leu Glu Gln Phe Val Glu Lys Lys Val Glu Ala 
        195                 200                 205             


Ala Glu Asn Asn Val Ser Ser Val Ala Arg Arg Glu Lys Glu Leu Tyr 
    210                 215                 220                 


Asp Gln Ile Ala Asp Leu Thr Asp Lys Asn Gly Glu Tyr Leu Glu Arg 
225                 230                 235                 240 


Ile Gly Glu Leu Glu Glu Arg Gln Lys Asn Leu Asp Asp Arg Ser Val 
                245                 250                 255     


Ser Thr Asn Ser Gly Ser Val Ser Thr Pro Tyr Asn Asn Leu Leu Asn 
            260                 265                 270         


Glu Tyr Asp Asp Leu Leu Ala Lys His Gly Glu Leu Leu Ser Glu Tyr 
        275                 280                 285             


Asp Ala Leu Lys Glu Lys Gln Asp Lys Asn Gln Glu Glu Asn Ser Lys 
    290                 295                 300                 


Asn Pro Ala Pro Ala Pro Ala Ser Ala Val Pro Val Lys Lys Glu Ala 
305                 310                 315                 320 


Thr Lys Leu Ser Glu Ala Glu Leu Tyr Asn Lys Ile Gln Glu Leu Glu 
                325                 330                 335     


Glu Gly Lys Ala Glu Leu Phe Asp Lys Leu Glu Lys Val Glu Glu Asp 
            340                 345                 350         


Asn Pro Arg Tyr Thr Asp Ala His Asn Ala Val Thr Gln Gly Arg Thr 
        355                 360                 365             


Val Pro Leu Gln Asn Leu Leu His Glu Met Asp Lys Asn Gly Lys Leu 
    370                 375                 380                 


Arg Ser Glu Asn Glu Glu Leu Lys Ala Asp Leu Gln Lys Lys Glu Gln 
385                 390                 395                 400 


Glu His His His His His His 
                405         


<210>  13
<211>  1463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  13
agatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa       60

ttcccctcta gaaataattt tgtttaactt taagaaggag atatcatatg aacggtgacg      120

gtaacccgcg tgaagttatc gaagacctgg ctgctaacaa cccggctatc cagaacatcc      180

gtctgcgtca cgaaaacaaa gacctgaaag ctcgtctgga aaacgctatg gaagttgctg      240

gtcgtgactt caaacgtgct ctgctggacc aggttaccca gctgtacacc aaacacaact      300

ccaactacca gcagtacaac gctcaggctg gtcgtctgga cctgcgtcag aaagctgaat      360

acctgaaagg tctgaacgac tgggctgaac gtctgctgca ggaactgaac cgtgttttcc      420

cgcgtggtac cgttgaaaac ccggacaaag ctcgtgaact gctgaacaaa tacgacgttg      480

aaaaccgtgt tttcccgcgt ggtaccgttg aaaacccgga caaagctcgt gaactgctga      540

acaaatacga cgttgaaaac tccaaaaacc cggttccggt taaaaaagaa gctaaactgt      600

ccgaagctga actgcacgac aaaatcaaaa acctgtccaa aaacccggtt ccggttaaaa      660

aagaagctaa actgtccgaa gctgaactgc acgacaaaat caaaaacctg gctccgctga      720

cccgtgctac cgctgacaac aaagacgaac tgatcaaacg tgctaacgac tacgaaatcc      780

agaaccacca gctgaccgtt gaaaacaaaa aactgaaaac cgacaaagaa cagctgacca      840

aagaaaacga cgacctgaaa gctgaatccc cgaaatccac cgaaacctcc gctaacggtg      900

ctgacaaact ggctgacgct tacaacaccc tgctgaccga acacgaaaaa ctgcgtgacg      960

aatactacac cctgatcgac gctaaagaag aagaaccgcg ttacaaagct gaccactccg     1020

acctggttgc tgaaaaacag cgtctggaag acctgggtca gaaattcgaa cgtctgaaac     1080

agcgttccga actgtacctg cagcagtact acgacaacaa atccaacggt tacaaaggtg     1140

actggtacgt tcagcagctg gactccgttt ccggtctgga agttgctgac ccgtccgact     1200

ccaaaaaact gatcgaactg ggtctggcta aatacctgaa cgacaaactg ccgttcaaaa     1260

ccaaagaaga ctccgaaatc ctgtccgaac tgcgtgacgt tctgaaaaac aacggtgacg     1320

gtaacccgcg tgaagttatc gaagacctgg ctgctaacaa cccggctatc cagaacatcc     1380

gtctgcgtca cgaaaacaaa gacctgaaag ctcgtctgga aaacgctatg gaagttgctg     1440

gtcgtgactt caaacgtgct tag                                             1463


<210>  14
<211>  1463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  14
agatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa       60

ttcccctcta gaaataattt tgtttaactt taagaaggag atataccatg gctgaaatca      120

aaaaaccgca ggctgactcc gcttggaact ggccgaaaga atacaacgct ctgctgaaag      180

aaaacgaaga actgaaagtt gaacgtgaaa aatacctgtc ctacgctgac gacaaagaaa      240

aagacccgca gtaccgtgct gctgttaccc gtggtaccat caacgacccg cagcgtgcta      300

aagaagctct ggacaaatac gaactggaaa accacgctgt tacccgtggt accatcaacg      360

acccgcagcg tgctaaagaa gctctggaca aatacgaact ggaaaaccac accgaagtta      420

aagctgctgg tcagtccgct ccgaaaggta ccaacgtttc cgctgacctg tacaactccc      480

tgtgggacga aaacaaaacc ctgcgtgaaa aacaggaaga atacatcacc aaaatccaga      540

acgaagaaac caaaaacaaa gaagaagaac gtaccttcac cgaactgccg tacgaagctc      600

gttacaaagc ttggaaatcc gaaaacgacg aactgcgtga aaactaccgt cgtaccctgg      660

acaaattcaa caccgaacag ggtaaaacca cccgtctgga agaacagaac cgtgttcgtt      720

acacccgtca caccccggaa gacaaactga aaaaaatcat cgacgacctg gacgctaaag      780

aacaccgtgt tcgttacacc cgtcacaccc cggaagacaa actgaaaaaa atcatcgacg      840

acctggacgc taaagaacac cgtgtttaca tcacccgtcg tatgaccaaa gaagacgttg      900

aaaaaatcgc taacgacctg gacaccgaaa accacggtct gaaacagcag aacgaacagc      960

tgtccaccga aaaacagggt ctggaagaac agaacaaaca gctgtccacc gaccgtgttt     1020

cccgttccat gtcccgtgac gacctgctga accgtgctca ggacctggaa gctaaaaacc     1080

acggtctgga acaccagaac accaaactgt ccaccgaaaa caaaaccctg caggaacagg     1140

ctgaagctcg tcagaaagaa gttgctaccc gttcccagac cgacaccctg gaaaaagttc     1200

aggaacgtgc tgacaaattc gaaatcgaaa acaacaccct gaaactgaaa aactccgacc     1260

tgtccttcaa caacaaagct ctgaaagacc acaacgacga actgaccgaa gctgaaatca     1320

aaaaaccgca ggctgactcc gcttggaact ggccgaaaga atacaacgct ctgctgaaag     1380

aaaacgaaga actgaaagtt gaacgtgaaa aatacctgtc ctacgctgac gacaaagaaa     1440

aagacccgca gtaccgtgct tag                                             1463


<210>  15
<211>  1463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  15
agatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa       60

ttcccctcta gaaataattt tgtttaactt taagaaggag atataccatg gaaggtgttt      120

ccgttggttc cgacgcttcc ctgcacaacc gtatcaccga cctggaagaa gaacgtgaaa      180

aactgctgaa caaactggac aaagttgaag aagaacacaa aaaagaccac gaacagctgg      240

aaaaaaaatc cgaagacgtt gaatcctcca acaacgctga atcctccaac atctcccagg      300

aatccaaact gatcaacacc ctgaccgacg aaaacgaaaa actgcgtgaa gaactgcagc      360

agtactacgc tctgtccgac gctaaagaag aagaaccgcg ttacaaagct gacaaccagt      420

ccccggctcc ggttaaaaaa gaagctaaaa aactgaacga agctgaactg tacaacaaaa      480

tccaggaact ggaagaaggt aaagctgaac tgttcgacaa actggaaaaa gttgaagaag      540

aaaacaaaaa agttaaagaa gactccgaca acatcaaccg ttccgtttcc gttaaagaca      600

acgaaaaaga actgcacaac aaaatcgctg acctggaaga agaacgtggt gaacacctgg      660

acaaaatcga cgaactgaaa gaagaactga aagctaaaga aaaatcctcc gactcctccc      720

gtgaagttac caacgaactg accgcttcca tgtggaaagc tcaggctgac tccgctaaag      780

ctaaagctaa agaactggaa aaacaggttg aagaatacaa aaaaaactac gaaaccctgg      840

aaaaaggtta cgacgacctg gctgaatccc gttccgtttc ccagggttcc gtttccctgg      900

aactgtacga caaactgtcc gacgaaaacg acatcctgcg tgaaaaacag gacgaatacc      960

tgaccaaaat cgacggtctg gacaaagaaa acaaagaata cgcttcccag gaatcccaga     1020

actcccgttc catcaccaac gaacagctga tcgacaaact ggttgaagaa aacaacgacc     1080

tgaaagaaga acgtgctaaa tacctggacc tgctggacaa ccgtgaaaaa gacccgcagt     1140

accgtgctct gatgggtgaa gctgaaaaaa aagttgaagt tgctgactcc aacgcttcct     1200

ccgttgctaa actgtacaac cagatcgctg acctgaccga caaaaacggt gaatacctgg     1260

aacgtatcga agaactggaa gaacgtcaga aaaacctgga aaaactggaa gaaggtgttt     1320

ccgttggttc cgacgcttcc ctgcacaacc gtatcaccga cctggaagaa gaacgtgaaa     1380

aactgctgaa caaactggac aaagttgaag aagaacacaa aaaagaccac gaacagctgg     1440

aaaaaaaatc cgaagacgtt tag                                             1463


<210>  16
<211>  1313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  16
agatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa       60

ttcccctcta gaaataattt tgtttaactt taagaaggag atataccatg gacaacccgc      120

gttacaccga cgctcacaac gctgttaccc agggtcgtac cgttccgctg cagaacctgc      180

tgcacgaaat ggacaaaaac ggtaaactgc gttccgaaaa cgaagaactg aaagctgacc      240

tgcagaaaaa agaacaggaa gactcctcct cccgtgacat caccgaagct ggtgtttcca      300

aattctggaa atccaaattc gacgctgaac agaaccgtgc taacgaactg gaaaaaaaac      360

tgtccggtta cgaaaaagac tacaaaaccc tggaacagga atacgaaaac gctggttccg      420

aagaaaacgt tccgaaacag cagtacaacg ctctgtggga agaaaacgaa gacctgcgtg      480

gtcgtgaacg taaatacatc gctaaactgg aaaaagaaga aatccagaac ggtgaactga      540

acgaaaaaaa ccgtaaactg gaatccccgc gtgaagttac caacgaactg gctgcttccg      600

tttggaaaaa aaaagttgaa gaagctaaag aaaaagcttc caaactggaa aaacagctgg      660

aagaagctca gaaagactac tccgaaatcg aaggtaaact ggaacagttc gttgaaaaaa      720

aagttgaagc tgctgaaaac aacgtttcct ccgttgctcg tcgtgaaaaa gaactgtacg      780

accagatcgc tgacctgacc gacaaaaacg gtgaatacct ggaacgtatc ggtgaactgg      840

aagaacgtca gaaaaacctg gacgaccgtt ccgtttccac caactccggt tccgtttcca      900

ccccgtacaa caacctgctg aacgaatacg acgacctgct ggctaaacac ggtgaactgc      960

tgtccgaata cgacgctctg aaagaaaaac aggacaaaaa ccaggaagaa aactccaaaa     1020

acccggctcc ggctccggct tccgctgttc cggttaaaaa agaagctacc aaactgtccg     1080

aagctgaact gtacaacaaa atccaggaac tggaagaagg taaagctgaa ctgttcgaca     1140

aactggaaaa agttgaagaa gacaacccgc gttacaccga cgctcacaac gctgttaccc     1200

agggtcgtac cgttccgctg cagaacctgc tgcacgaaat ggacaaaaac ggtaaactgc     1260

gttccgaaaa cgaagaactg aaagctgacc tgcagaaaaa agaacaggaa tag            1313


<210>  17
<211>  1481
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  17
agatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa       60

ttcccctcta gaaataattt tgtttaactt taagaaggag atatcatatg aacggtgacg      120

gtaacccgcg tgaagttatc gaagacctgg ctgctaacaa cccggctatc cagaacatcc      180

gtctgcgtca cgaaaacaaa gacctgaaag ctcgtctgga aaacgctatg gaagttgctg      240

gtcgtgactt caaacgtgct ctgctggacc aggttaccca gctgtacacc aaacacaact      300

ccaactacca gcagtacaac gctcaggctg gtcgtctgga cctgcgtcag aaagctgaat      360

acctgaaagg tctgaacgac tgggctgaac gtctgctgca ggaactgaac cgtgttttcc      420

cgcgtggtac cgttgaaaac ccggacaaag ctcgtgaact gctgaacaaa tacgacgttg      480

aaaaccgtgt tttcccgcgt ggtaccgttg aaaacccgga caaagctcgt gaactgctga      540

acaaatacga cgttgaaaac tccaaaaacc cggttccggt taaaaaagaa gctaaactgt      600

ccgaagctga actgcacgac aaaatcaaaa acctgtccaa aaacccggtt ccggttaaaa      660

aagaagctaa actgtccgaa gctgaactgc acgacaaaat caaaaacctg gctccgctga      720

cccgtgctac cgctgacaac aaagacgaac tgatcaaacg tgctaacgac tacgaaatcc      780

agaaccacca gctgaccgtt gaaaacaaaa aactgaaaac cgacaaagaa cagctgacca      840

aagaaaacga cgacctgaaa gctgaatccc cgaaatccac cgaaacctcc gctaacggtg      900

ctgacaaact ggctgacgct tacaacaccc tgctgaccga acacgaaaaa ctgcgtgacg      960

aatactacac cctgatcgac gctaaagaag aagaaccgcg ttacaaagct gaccactccg     1020

acctggttgc tgaaaaacag cgtctggaag acctgggtca gaaattcgaa cgtctgaaac     1080

agcgttccga actgtacctg cagcagtact acgacaacaa atccaacggt tacaaaggtg     1140

actggtacgt tcagcagctg gactccgttt ccggtctgga agttgctgac ccgtccgact     1200

ccaaaaaact gatcgaactg ggtctggcta aatacctgaa cgacaaactg ccgttcaaaa     1260

ccaaagaaga ctccgaaatc ctgtccgaac tgcgtgacgt tctgaaaaac aacggtgacg     1320

gtaacccgcg tgaagttatc gaagacctgg ctgctaacaa cccggctatc cagaacatcc     1380

gtctgcgtca cgaaaacaaa gacctgaaag ctcgtctgga aaacgctatg gaagttgctg     1440

gtcgtgactt caaacgtgct caccaccacc accaccacta g                         1481


<210>  18
<211>  1481
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  18
agatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa       60

ttcccctcta gaaataattt tgtttaactt taagaaggag atataccatg gctgaaatca      120

aaaaaccgca ggctgactcc gcttggaact ggccgaaaga atacaacgct ctgctgaaag      180

aaaacgaaga actgaaagtt gaacgtgaaa aatacctgtc ctacgctgac gacaaagaaa      240

aagacccgca gtaccgtgct gctgttaccc gtggtaccat caacgacccg cagcgtgcta      300

aagaagctct ggacaaatac gaactggaaa accacgctgt tacccgtggt accatcaacg      360

acccgcagcg tgctaaagaa gctctggaca aatacgaact ggaaaaccac accgaagtta      420

aagctgctgg tcagtccgct ccgaaaggta ccaacgtttc cgctgacctg tacaactccc      480

tgtgggacga aaacaaaacc ctgcgtgaaa aacaggaaga atacatcacc aaaatccaga      540

acgaagaaac caaaaacaaa gaagaagaac gtaccttcac cgaactgccg tacgaagctc      600

gttacaaagc ttggaaatcc gaaaacgacg aactgcgtga aaactaccgt cgtaccctgg      660

acaaattcaa caccgaacag ggtaaaacca cccgtctgga agaacagaac cgtgttcgtt      720

acacccgtca caccccggaa gacaaactga aaaaaatcat cgacgacctg gacgctaaag      780

aacaccgtgt tcgttacacc cgtcacaccc cggaagacaa actgaaaaaa atcatcgacg      840

acctggacgc taaagaacac cgtgtttaca tcacccgtcg tatgaccaaa gaagacgttg      900

aaaaaatcgc taacgacctg gacaccgaaa accacggtct gaaacagcag aacgaacagc      960

tgtccaccga aaaacagggt ctggaagaac agaacaaaca gctgtccacc gaccgtgttt     1020

cccgttccat gtcccgtgac gacctgctga accgtgctca ggacctggaa gctaaaaacc     1080

acggtctgga acaccagaac accaaactgt ccaccgaaaa caaaaccctg caggaacagg     1140

ctgaagctcg tcagaaagaa gttgctaccc gttcccagac cgacaccctg gaaaaagttc     1200

aggaacgtgc tgacaaattc gaaatcgaaa acaacaccct gaaactgaaa aactccgacc     1260

tgtccttcaa caacaaagct ctgaaagacc acaacgacga actgaccgaa gctgaaatca     1320

aaaaaccgca ggctgactcc gcttggaact ggccgaaaga atacaacgct ctgctgaaag     1380

aaaacgaaga actgaaagtt gaacgtgaaa aatacctgtc ctacgctgac gacaaagaaa     1440

aagacccgca gtaccgtgct caccaccacc accaccacta g                         1481


<210>  19
<211>  1481
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  19
agatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa       60

ttcccctcta gaaataattt tgtttaactt taagaaggag atataccatg gaaggtgttt      120

ccgttggttc cgacgcttcc ctgcacaacc gtatcaccga cctggaagaa gaacgtgaaa      180

aactgctgaa caaactggac aaagttgaag aagaacacaa aaaagaccac gaacagctgg      240

aaaaaaaatc cgaagacgtt gaatcctcca acaacgctga atcctccaac atctcccagg      300

aatccaaact gatcaacacc ctgaccgacg aaaacgaaaa actgcgtgaa gaactgcagc      360

agtactacgc tctgtccgac gctaaagaag aagaaccgcg ttacaaagct gacaaccagt      420

ccccggctcc ggttaaaaaa gaagctaaaa aactgaacga agctgaactg tacaacaaaa      480

tccaggaact ggaagaaggt aaagctgaac tgttcgacaa actggaaaaa gttgaagaag      540

aaaacaaaaa agttaaagaa gactccgaca acatcaaccg ttccgtttcc gttaaagaca      600

acgaaaaaga actgcacaac aaaatcgctg acctggaaga agaacgtggt gaacacctgg      660

acaaaatcga cgaactgaaa gaagaactga aagctaaaga aaaatcctcc gactcctccc      720

gtgaagttac caacgaactg accgcttcca tgtggaaagc tcaggctgac tccgctaaag      780

ctaaagctaa agaactggaa aaacaggttg aagaatacaa aaaaaactac gaaaccctgg      840

aaaaaggtta cgacgacctg gctgaatccc gttccgtttc ccagggttcc gtttccctgg      900

aactgtacga caaactgtcc gacgaaaacg acatcctgcg tgaaaaacag gacgaatacc      960

tgaccaaaat cgacggtctg gacaaagaaa acaaagaata cgcttcccag gaatcccaga     1020

actcccgttc catcaccaac gaacagctga tcgacaaact ggttgaagaa aacaacgacc     1080

tgaaagaaga acgtgctaaa tacctggacc tgctggacaa ccgtgaaaaa gacccgcagt     1140

accgtgctct gatgggtgaa gctgaaaaaa aagttgaagt tgctgactcc aacgcttcct     1200

ccgttgctaa actgtacaac cagatcgctg acctgaccga caaaaacggt gaatacctgg     1260

aacgtatcga agaactggaa gaacgtcaga aaaacctgga aaaactggaa gaaggtgttt     1320

ccgttggttc cgacgcttcc ctgcacaacc gtatcaccga cctggaagaa gaacgtgaaa     1380

aactgctgaa caaactggac aaagttgaag aagaacacaa aaaagaccac gaacagctgg     1440

aaaaaaaatc cgaagacgtt caccaccacc accaccacta g                         1481


<210>  20
<211>  1331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  20
agatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa       60

ttcccctcta gaaataattt tgtttaactt taagaaggag atataccatg gacaacccgc      120

gttacaccga cgctcacaac gctgttaccc agggtcgtac cgttccgctg cagaacctgc      180

tgcacgaaat ggacaaaaac ggtaaactgc gttccgaaaa cgaagaactg aaagctgacc      240

tgcagaaaaa agaacaggaa gactcctcct cccgtgacat caccgaagct ggtgtttcca      300

aattctggaa atccaaattc gacgctgaac agaaccgtgc taacgaactg gaaaaaaaac      360

tgtccggtta cgaaaaagac tacaaaaccc tggaacagga atacgaaaac gctggttccg      420

aagaaaacgt tccgaaacag cagtacaacg ctctgtggga agaaaacgaa gacctgcgtg      480

gtcgtgaacg taaatacatc gctaaactgg aaaaagaaga aatccagaac ggtgaactga      540

acgaaaaaaa ccgtaaactg gaatccccgc gtgaagttac caacgaactg gctgcttccg      600

tttggaaaaa aaaagttgaa gaagctaaag aaaaagcttc caaactggaa aaacagctgg      660

aagaagctca gaaagactac tccgaaatcg aaggtaaact ggaacagttc gttgaaaaaa      720

aagttgaagc tgctgaaaac aacgtttcct ccgttgctcg tcgtgaaaaa gaactgtacg      780

accagatcgc tgacctgacc gacaaaaacg gtgaatacct ggaacgtatc ggtgaactgg      840

aagaacgtca gaaaaacctg gacgaccgtt ccgtttccac caactccggt tccgtttcca      900

ccccgtacaa caacctgctg aacgaatacg acgacctgct ggctaaacac ggtgaactgc      960

tgtccgaata cgacgctctg aaagaaaaac aggacaaaaa ccaggaagaa aactccaaaa     1020

acccggctcc ggctccggct tccgctgttc cggttaaaaa agaagctacc aaactgtccg     1080

aagctgaact gtacaacaaa atccaggaac tggaagaagg taaagctgaa ctgttcgaca     1140

aactggaaaa agttgaagaa gacaacccgc gttacaccga cgctcacaac gctgttaccc     1200

agggtcgtac cgttccgctg cagaacctgc tgcacgaaat ggacaaaaac ggtaaactgc     1260

gttccgaaaa cgaagaactg aaagctgacc tgcagaaaaa agaacaggaa caccaccacc     1320

accaccacta g                                                          1331


<210>  21
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  21
atgaacggtg acggtaaccc gcgtgaagtt atcgaagacc tggctgctaa caacccggct       60

atccagaaca tccgtctgcg tcacgaaaac aaagacctga aagctcgtct ggaaaacgct      120

atggaagttg ctggtcgtga cttcaaacgt gctctgctgg accaggttac ccagctgtac      180

accaaacaca actccaacta ccagcagtac aacgctcagg ctggtcgtct ggacctgcgt      240

cagaaagctg aatacctgaa aggtctgaac gactgggctg aacgtctgct gcaggaactg      300

aaccgtgttt tcccgcgtgg taccgttgaa aacccggaca aagctcgtga actgctgaac      360

aaatacgacg ttgaaaaccg tgttttcccg cgtggtaccg ttgaaaaccc ggacaaagct      420

cgtgaactgc tgaacaaata cgacgttgaa aactccaaaa acccggttcc ggttaaaaaa      480

gaagctaaac tgtccgaagc tgaactgcac gacaaaatca aaaacctgtc caaaaacccg      540

gttccggtta aaaaagaagc taaactgtcc gaagctgaac tgcacgacaa aatcaaaaac      600

ctggctccgc tgacccgtgc taccgctgac aacaaagacg aactgatcaa acgtgctaac      660

gactacgaaa tccagaacca ccagctgacc gttgaaaaca aaaaactgaa aaccgacaaa      720

gaacagctga ccaaagaaaa cgacgacctg aaagctgaat ccccgaaatc caccgaaacc      780

tccgctaacg gtgctgacaa actggctgac gcttacaaca ccctgctgac cgaacacgaa      840

aaactgcgtg acgaatacta caccctgatc gacgctaaag aagaagaacc gcgttacaaa      900

gctgaccact ccgacctggt tgctgaaaaa cagcgtctgg aagacctggg tcagaaattc      960

gaacgtctga aacagcgttc cgaactgtac ctgcagcagt actacgacaa caaatccaac     1020

ggttacaaag gtgactggta cgttcagcag ctggactccg tttccggtct ggaagttgct     1080

gacccgtccg actccaaaaa actgatcgaa ctgggtctgg ctaaatacct gaacgacaaa     1140

ctgccgttca aaaccaaaga agactccgaa atcctgtccg aactgcgtga cgttctgaaa     1200

aacaacggtg acggtaaccc gcgtgaagtt atcgaagacc tggctgctaa caacccggct     1260

atccagaaca tccgtctgcg tcacgaaaac aaagacctga aagctcgtct ggaaaacgct     1320

atggaagttg ctggtcgtga cttcaaacgt gcttag                               1356


<210>  22
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  22
atggctgaaa tcaaaaaacc gcaggctgac tccgcttgga actggccgaa agaatacaac       60

gctctgctga aagaaaacga agaactgaaa gttgaacgtg aaaaatacct gtcctacgct      120

gacgacaaag aaaaagaccc gcagtaccgt gctgctgtta cccgtggtac catcaacgac      180

ccgcagcgtg ctaaagaagc tctggacaaa tacgaactgg aaaaccacgc tgttacccgt      240

ggtaccatca acgacccgca gcgtgctaaa gaagctctgg acaaatacga actggaaaac      300

cacaccgaag ttaaagctgc tggtcagtcc gctccgaaag gtaccaacgt ttccgctgac      360

ctgtacaact ccctgtggga cgaaaacaaa accctgcgtg aaaaacagga agaatacatc      420

accaaaatcc agaacgaaga aaccaaaaac aaagaagaag aacgtacctt caccgaactg      480

ccgtacgaag ctcgttacaa agcttggaaa tccgaaaacg acgaactgcg tgaaaactac      540

cgtcgtaccc tggacaaatt caacaccgaa cagggtaaaa ccacccgtct ggaagaacag      600

aaccgtgttc gttacacccg tcacaccccg gaagacaaac tgaaaaaaat catcgacgac      660

ctggacgcta aagaacaccg tgttcgttac acccgtcaca ccccggaaga caaactgaaa      720

aaaatcatcg acgacctgga cgctaaagaa caccgtgttt acatcacccg tcgtatgacc      780

aaagaagacg ttgaaaaaat cgctaacgac ctggacaccg aaaaccacgg tctgaaacag      840

cagaacgaac agctgtccac cgaaaaacag ggtctggaag aacagaacaa acagctgtcc      900

accgaccgtg tttcccgttc catgtcccgt gacgacctgc tgaaccgtgc tcaggacctg      960

gaagctaaaa accacggtct ggaacaccag aacaccaaac tgtccaccga aaacaaaacc     1020

ctgcaggaac aggctgaagc tcgtcagaaa gaagttgcta cccgttccca gaccgacacc     1080

ctggaaaaag ttcaggaacg tgctgacaaa ttcgaaatcg aaaacaacac cctgaaactg     1140

aaaaactccg acctgtcctt caacaacaaa gctctgaaag accacaacga cgaactgacc     1200

gaagctgaaa tcaaaaaacc gcaggctgac tccgcttgga actggccgaa agaatacaac     1260

gctctgctga aagaaaacga agaactgaaa gttgaacgtg aaaaatacct gtcctacgct     1320

gacgacaaag aaaaagaccc gcagtaccgt gcttag                               1356


<210>  23
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  23
atggaaggtg tttccgttgg ttccgacgct tccctgcaca accgtatcac cgacctggaa       60

gaagaacgtg aaaaactgct gaacaaactg gacaaagttg aagaagaaca caaaaaagac      120

cacgaacagc tggaaaaaaa atccgaagac gttgaatcct ccaacaacgc tgaatcctcc      180

aacatctccc aggaatccaa actgatcaac accctgaccg acgaaaacga aaaactgcgt      240

gaagaactgc agcagtacta cgctctgtcc gacgctaaag aagaagaacc gcgttacaaa      300

gctgacaacc agtccccggc tccggttaaa aaagaagcta aaaaactgaa cgaagctgaa      360

ctgtacaaca aaatccagga actggaagaa ggtaaagctg aactgttcga caaactggaa      420

aaagttgaag aagaaaacaa aaaagttaaa gaagactccg acaacatcaa ccgttccgtt      480

tccgttaaag acaacgaaaa agaactgcac aacaaaatcg ctgacctgga agaagaacgt      540

ggtgaacacc tggacaaaat cgacgaactg aaagaagaac tgaaagctaa agaaaaatcc      600

tccgactcct cccgtgaagt taccaacgaa ctgaccgctt ccatgtggaa agctcaggct      660

gactccgcta aagctaaagc taaagaactg gaaaaacagg ttgaagaata caaaaaaaac      720

tacgaaaccc tggaaaaagg ttacgacgac ctggctgaat cccgttccgt ttcccagggt      780

tccgtttccc tggaactgta cgacaaactg tccgacgaaa acgacatcct gcgtgaaaaa      840

caggacgaat acctgaccaa aatcgacggt ctggacaaag aaaacaaaga atacgcttcc      900

caggaatccc agaactcccg ttccatcacc aacgaacagc tgatcgacaa actggttgaa      960

gaaaacaacg acctgaaaga agaacgtgct aaatacctgg acctgctgga caaccgtgaa     1020

aaagacccgc agtaccgtgc tctgatgggt gaagctgaaa aaaaagttga agttgctgac     1080

tccaacgctt cctccgttgc taaactgtac aaccagatcg ctgacctgac cgacaaaaac     1140

ggtgaatacc tggaacgtat cgaagaactg gaagaacgtc agaaaaacct ggaaaaactg     1200

gaagaaggtg tttccgttgg ttccgacgct tccctgcaca accgtatcac cgacctggaa     1260

gaagaacgtg aaaaactgct gaacaaactg gacaaagttg aagaagaaca caaaaaagac     1320

cacgaacagc tggaaaaaaa atccgaagac gtttag                               1356


<210>  24
<211>  1206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  24
atggacaacc cgcgttacac cgacgctcac aacgctgtta cccagggtcg taccgttccg       60

ctgcagaacc tgctgcacga aatggacaaa aacggtaaac tgcgttccga aaacgaagaa      120

ctgaaagctg acctgcagaa aaaagaacag gaagactcct cctcccgtga catcaccgaa      180

gctggtgttt ccaaattctg gaaatccaaa ttcgacgctg aacagaaccg tgctaacgaa      240

ctggaaaaaa aactgtccgg ttacgaaaaa gactacaaaa ccctggaaca ggaatacgaa      300

aacgctggtt ccgaagaaaa cgttccgaaa cagcagtaca acgctctgtg ggaagaaaac      360

gaagacctgc gtggtcgtga acgtaaatac atcgctaaac tggaaaaaga agaaatccag      420

aacggtgaac tgaacgaaaa aaaccgtaaa ctggaatccc cgcgtgaagt taccaacgaa      480

ctggctgctt ccgtttggaa aaaaaaagtt gaagaagcta aagaaaaagc ttccaaactg      540

gaaaaacagc tggaagaagc tcagaaagac tactccgaaa tcgaaggtaa actggaacag      600

ttcgttgaaa aaaaagttga agctgctgaa aacaacgttt cctccgttgc tcgtcgtgaa      660

aaagaactgt acgaccagat cgctgacctg accgacaaaa acggtgaata cctggaacgt      720

atcggtgaac tggaagaacg tcagaaaaac ctggacgacc gttccgtttc caccaactcc      780

ggttccgttt ccaccccgta caacaacctg ctgaacgaat acgacgacct gctggctaaa      840

cacggtgaac tgctgtccga atacgacgct ctgaaagaaa aacaggacaa aaaccaggaa      900

gaaaactcca aaaacccggc tccggctccg gcttccgctg ttccggttaa aaaagaagct      960

accaaactgt ccgaagctga actgtacaac aaaatccagg aactggaaga aggtaaagct     1020

gaactgttcg acaaactgga aaaagttgaa gaagacaacc cgcgttacac cgacgctcac     1080

aacgctgtta cccagggtcg taccgttccg ctgcagaacc tgctgcacga aatggacaaa     1140

aacggtaaac tgcgttccga aaacgaagaa ctgaaagctg acctgcagaa aaaagaacag     1200

gaatag                                                                1206


<210>  25
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  25
aacggtgacg gtaacccgcg tgaagttatc gaagacctgg ctgctaacaa cccggctatc       60

cagaacatcc gtctgcgtca cgaaaacaaa gacctgaaag ctcgtctgga aaacgctatg      120

gaagttgctg gtcgtgactt caaacgtgct ctgctggacc aggttaccca gctgtacacc      180

aaacacaact ccaactacca gcagtacaac gctcaggctg gtcgtctgga cctgcgtcag      240

aaagctgaat acctgaaagg tctgaacgac tgggctgaac gtctgctgca ggaactgaac      300

cgtgttttcc cgcgtggtac cgttgaaaac ccggacaaag ctcgtgaact gctgaacaaa      360

tacgacgttg aaaaccgtgt tttcccgcgt ggtaccgttg aaaacccgga caaagctcgt      420

gaactgctga acaaatacga cgttgaaaac tccaaaaacc cggttccggt taaaaaagaa      480

gctaaactgt ccgaagctga actgcacgac aaaatcaaaa acctgtccaa aaacccggtt      540

ccggttaaaa aagaagctaa actgtccgaa gctgaactgc acgacaaaat caaaaacctg      600

gctccgctga cccgtgctac cgctgacaac aaagacgaac tgatcaaacg tgctaacgac      660

tacgaaatcc agaaccacca gctgaccgtt gaaaacaaaa aactgaaaac cgacaaagaa      720

cagctgacca aagaaaacga cgacctgaaa gctgaatccc cgaaatccac cgaaacctcc      780

gctaacggtg ctgacaaact ggctgacgct tacaacaccc tgctgaccga acacgaaaaa      840

ctgcgtgacg aatactacac cctgatcgac gctaaagaag aagaaccgcg ttacaaagct      900

gaccactccg acctggttgc tgaaaaacag cgtctggaag acctgggtca gaaattcgaa      960

cgtctgaaac agcgttccga actgtacctg cagcagtact acgacaacaa atccaacggt     1020

tacaaaggtg actggtacgt tcagcagctg gactccgttt ccggtctgga agttgctgac     1080

ccgtccgact ccaaaaaact gatcgaactg ggtctggcta aatacctgaa cgacaaactg     1140

ccgttcaaaa ccaaagaaga ctccgaaatc ctgtccgaac tgcgtgacgt tctgaaaaac     1200

aacggtgacg gtaacccgcg tgaagttatc gaagacctgg ctgctaacaa cccggctatc     1260

cagaacatcc gtctgcgtca cgaaaacaaa gacctgaaag ctcgtctgga aaacgctatg     1320

gaagttgctg gtcgtgactt caaacgtgct tag                                  1353


<210>  26
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  26
gctgaaatca aaaaaccgca ggctgactcc gcttggaact ggccgaaaga atacaacgct       60

ctgctgaaag aaaacgaaga actgaaagtt gaacgtgaaa aatacctgtc ctacgctgac      120

gacaaagaaa aagacccgca gtaccgtgct gctgttaccc gtggtaccat caacgacccg      180

cagcgtgcta aagaagctct ggacaaatac gaactggaaa accacgctgt tacccgtggt      240

accatcaacg acccgcagcg tgctaaagaa gctctggaca aatacgaact ggaaaaccac      300

accgaagtta aagctgctgg tcagtccgct ccgaaaggta ccaacgtttc cgctgacctg      360

tacaactccc tgtgggacga aaacaaaacc ctgcgtgaaa aacaggaaga atacatcacc      420

aaaatccaga acgaagaaac caaaaacaaa gaagaagaac gtaccttcac cgaactgccg      480

tacgaagctc gttacaaagc ttggaaatcc gaaaacgacg aactgcgtga aaactaccgt      540

cgtaccctgg acaaattcaa caccgaacag ggtaaaacca cccgtctgga agaacagaac      600

cgtgttcgtt acacccgtca caccccggaa gacaaactga aaaaaatcat cgacgacctg      660

gacgctaaag aacaccgtgt tcgttacacc cgtcacaccc cggaagacaa actgaaaaaa      720

atcatcgacg acctggacgc taaagaacac cgtgtttaca tcacccgtcg tatgaccaaa      780

gaagacgttg aaaaaatcgc taacgacctg gacaccgaaa accacggtct gaaacagcag      840

aacgaacagc tgtccaccga aaaacagggt ctggaagaac agaacaaaca gctgtccacc      900

gaccgtgttt cccgttccat gtcccgtgac gacctgctga accgtgctca ggacctggaa      960

gctaaaaacc acggtctgga acaccagaac accaaactgt ccaccgaaaa caaaaccctg     1020

caggaacagg ctgaagctcg tcagaaagaa gttgctaccc gttcccagac cgacaccctg     1080

gaaaaagttc aggaacgtgc tgacaaattc gaaatcgaaa acaacaccct gaaactgaaa     1140

aactccgacc tgtccttcaa caacaaagct ctgaaagacc acaacgacga actgaccgaa     1200

gctgaaatca aaaaaccgca ggctgactcc gcttggaact ggccgaaaga atacaacgct     1260

ctgctgaaag aaaacgaaga actgaaagtt gaacgtgaaa aatacctgtc ctacgctgac     1320

gacaaagaaa aagacccgca gtaccgtgct tag                                  1353


<210>  27
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  27
gaaggtgttt ccgttggttc cgacgcttcc ctgcacaacc gtatcaccga cctggaagaa       60

gaacgtgaaa aactgctgaa caaactggac aaagttgaag aagaacacaa aaaagaccac      120

gaacagctgg aaaaaaaatc cgaagacgtt gaatcctcca acaacgctga atcctccaac      180

atctcccagg aatccaaact gatcaacacc ctgaccgacg aaaacgaaaa actgcgtgaa      240

gaactgcagc agtactacgc tctgtccgac gctaaagaag aagaaccgcg ttacaaagct      300

gacaaccagt ccccggctcc ggttaaaaaa gaagctaaaa aactgaacga agctgaactg      360

tacaacaaaa tccaggaact ggaagaaggt aaagctgaac tgttcgacaa actggaaaaa      420

gttgaagaag aaaacaaaaa agttaaagaa gactccgaca acatcaaccg ttccgtttcc      480

gttaaagaca acgaaaaaga actgcacaac aaaatcgctg acctggaaga agaacgtggt      540

gaacacctgg acaaaatcga cgaactgaaa gaagaactga aagctaaaga aaaatcctcc      600

gactcctccc gtgaagttac caacgaactg accgcttcca tgtggaaagc tcaggctgac      660

tccgctaaag ctaaagctaa agaactggaa aaacaggttg aagaatacaa aaaaaactac      720

gaaaccctgg aaaaaggtta cgacgacctg gctgaatccc gttccgtttc ccagggttcc      780

gtttccctgg aactgtacga caaactgtcc gacgaaaacg acatcctgcg tgaaaaacag      840

gacgaatacc tgaccaaaat cgacggtctg gacaaagaaa acaaagaata cgcttcccag      900

gaatcccaga actcccgttc catcaccaac gaacagctga tcgacaaact ggttgaagaa      960

aacaacgacc tgaaagaaga acgtgctaaa tacctggacc tgctggacaa ccgtgaaaaa     1020

gacccgcagt accgtgctct gatgggtgaa gctgaaaaaa aagttgaagt tgctgactcc     1080

aacgcttcct ccgttgctaa actgtacaac cagatcgctg acctgaccga caaaaacggt     1140

gaatacctgg aacgtatcga agaactggaa gaacgtcaga aaaacctgga aaaactggaa     1200

gaaggtgttt ccgttggttc cgacgcttcc ctgcacaacc gtatcaccga cctggaagaa     1260

gaacgtgaaa aactgctgaa caaactggac aaagttgaag aagaacacaa aaaagaccac     1320

gaacagctgg aaaaaaaatc cgaagacgtt tag                                  1353


<210>  28
<211>  1203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding a fusion protein of group A streptococcus
       M proteins.

<400>  28
gacaacccgc gttacaccga cgctcacaac gctgttaccc agggtcgtac cgttccgctg       60

cagaacctgc tgcacgaaat ggacaaaaac ggtaaactgc gttccgaaaa cgaagaactg      120

aaagctgacc tgcagaaaaa agaacaggaa gactcctcct cccgtgacat caccgaagct      180

ggtgtttcca aattctggaa atccaaattc gacgctgaac agaaccgtgc taacgaactg      240

gaaaaaaaac tgtccggtta cgaaaaagac tacaaaaccc tggaacagga atacgaaaac      300

gctggttccg aagaaaacgt tccgaaacag cagtacaacg ctctgtggga agaaaacgaa      360

gacctgcgtg gtcgtgaacg taaatacatc gctaaactgg aaaaagaaga aatccagaac      420

ggtgaactga acgaaaaaaa ccgtaaactg gaatccccgc gtgaagttac caacgaactg      480

gctgcttccg tttggaaaaa aaaagttgaa gaagctaaag aaaaagcttc caaactggaa      540

aaacagctgg aagaagctca gaaagactac tccgaaatcg aaggtaaact ggaacagttc      600

gttgaaaaaa aagttgaagc tgctgaaaac aacgtttcct ccgttgctcg tcgtgaaaaa      660

gaactgtacg accagatcgc tgacctgacc gacaaaaacg gtgaatacct ggaacgtatc      720

ggtgaactgg aagaacgtca gaaaaacctg gacgaccgtt ccgtttccac caactccggt      780

tccgtttcca ccccgtacaa caacctgctg aacgaatacg acgacctgct ggctaaacac      840

ggtgaactgc tgtccgaata cgacgctctg aaagaaaaac aggacaaaaa ccaggaagaa      900

aactccaaaa acccggctcc ggctccggct tccgctgttc cggttaaaaa agaagctacc      960

aaactgtccg aagctgaact gtacaacaaa atccaggaac tggaagaagg taaagctgaa     1020

ctgttcgaca aactggaaaa agttgaagaa gacaacccgc gttacaccga cgctcacaac     1080

gctgttaccc agggtcgtac cgttccgctg cagaacctgc tgcacgaaat ggacaaaaac     1140

ggtaaactgc gttccgaaaa cgaagaactg aaagctgacc tgcagaaaaa agaacaggaa     1200

tag                                                                   1203


<210>  29
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  29

Asn Gly Asp Gly Asn Pro Arg Glu Val Ile Glu Asp Leu Ala Ala Asn 
1               5                   10                  15      


Asn Pro Ala Ile Gln Asn Ile Arg Leu Arg His Glu Asn Lys Asp Leu 
            20                  25                  30          


Lys Ala Arg Leu Glu Asn Ala Met Glu Val Ala Gly Arg Asp Phe Lys 
        35                  40                  45              


Arg Ala 
    50  


<210>  30
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  30

Leu Leu Asp Gln Val Thr Gln Leu Tyr Thr Lys His Asn Ser Asn Tyr 
1               5                   10                  15      


Gln Gln Tyr Asn Ala Gln Ala Gly Arg Leu Asp Leu Arg Gln Lys Ala 
            20                  25                  30          


Glu Tyr Leu Lys Gly Leu Asn Asp Trp Ala Glu Arg Leu Leu Gln Glu 
        35                  40                  45              


Leu Asn 
    50  


<210>  31
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  31

Arg Val Phe Pro Arg Gly Thr Val Glu Asn Pro Asp Lys Ala Arg Glu 
1               5                   10                  15      


Leu Leu Asn Lys Tyr Asp Val Glu Asn Arg Val Phe Pro Arg Gly Thr 
            20                  25                  30          


Val Glu Asn Pro Asp Lys Ala Arg Glu Leu Leu Asn Lys Tyr Asp Val 
        35                  40                  45              


Glu Asn 
    50  


<210>  32
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  32

Ser Lys Asn Pro Val Pro Val Lys Lys Glu Ala Lys Leu Ser Glu Ala 
1               5                   10                  15      


Glu Leu His Asp Lys Ile Lys Asn Leu Ser Lys Asn Pro Val Pro Val 
            20                  25                  30          


Lys Lys Glu Ala Lys Leu Ser Glu Ala Glu Leu His Asp Lys Ile Lys 
        35                  40                  45              


Asn Leu 
    50  


<210>  33
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  33

Ala Pro Leu Thr Arg Ala Thr Ala Asp Asn Lys Asp Glu Leu Ile Lys 
1               5                   10                  15      


Arg Ala Asn Asp Tyr Glu Ile Gln Asn His Gln Leu Thr Val Glu Asn 
            20                  25                  30          


Lys Lys Leu Lys Thr Asp Lys Glu Gln Leu Thr Lys Glu Asn Asp Asp 
        35                  40                  45              


Leu Lys 
    50  


<210>  34
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  34

Ala Glu Ser Pro Lys Ser Thr Glu Thr Ser Ala Asn Gly Ala Asp Lys 
1               5                   10                  15      


Leu Ala Asp Ala Tyr Asn Thr Leu Leu Thr Glu His Glu Lys Leu Arg 
            20                  25                  30          


Asp Glu Tyr Tyr Thr Leu Ile Asp Ala Lys Glu Glu Glu Pro Arg Tyr 
        35                  40                  45              


Lys Ala 
    50  


<210>  35
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  35

Asp His Ser Asp Leu Val Ala Glu Lys Gln Arg Leu Glu Asp Leu Gly 
1               5                   10                  15      


Gln Lys Phe Glu Arg Leu Lys Gln Arg Ser Glu Leu Tyr Leu Gln Gln 
            20                  25                  30          


Tyr Tyr Asp Asn Lys Ser Asn Gly Tyr Lys Gly Asp Trp Tyr Val Gln 
        35                  40                  45              


Gln Leu 
    50  


<210>  36
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  36

Asp Ser Val Ser Gly Leu Glu Val Ala Asp Pro Ser Asp Ser Lys Lys 
1               5                   10                  15      


Leu Ile Glu Leu Gly Leu Ala Lys Tyr Leu Asn Asp Lys Leu Pro Phe 
            20                  25                  30          


Lys Thr Lys Glu Asp Ser Glu Ile Leu Ser Glu Leu Arg Asp Val Leu 
        35                  40                  45              


Lys Asn 
    50  


<210>  37
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  37

Ala Glu Ile Lys Lys Pro Gln Ala Asp Ser Ala Trp Asn Trp Pro Lys 
1               5                   10                  15      


Glu Tyr Asn Ala Leu Leu Lys Glu Asn Glu Glu Leu Lys Val Glu Arg 
            20                  25                  30          


Glu Lys Tyr Leu Ser Tyr Ala Asp Asp Lys Glu Lys Asp Pro Gln Tyr 
        35                  40                  45              


Arg Ala 
    50  


<210>  38
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  38

Ala Val Thr Arg Gly Thr Ile Asn Asp Pro Gln Arg Ala Lys Glu Ala 
1               5                   10                  15      


Leu Asp Lys Tyr Glu Leu Glu Asn His Ala Val Thr Arg Gly Thr Ile 
            20                  25                  30          


Asn Asp Pro Gln Arg Ala Lys Glu Ala Leu Asp Lys Tyr Glu Leu Glu 
        35                  40                  45              


Asn His 
    50  


<210>  39
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  39

Thr Glu Val Lys Ala Ala Gly Gln Ser Ala Pro Lys Gly Thr Asn Val 
1               5                   10                  15      


Ser Ala Asp Leu Tyr Asn Ser Leu Trp Asp Glu Asn Lys Thr Leu Arg 
            20                  25                  30          


Glu Lys Gln Glu Glu Tyr Ile Thr Lys Ile Gln Asn Glu Glu Thr Lys 
        35                  40                  45              


Asn Lys 
    50  


<210>  40
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  40

Glu Glu Glu Arg Thr Phe Thr Glu Leu Pro Tyr Glu Ala Arg Tyr Lys 
1               5                   10                  15      


Ala Trp Lys Ser Glu Asn Asp Glu Leu Arg Glu Asn Tyr Arg Arg Thr 
            20                  25                  30          


Leu Asp Lys Phe Asn Thr Glu Gln Gly Lys Thr Thr Arg Leu Glu Glu 
        35                  40                  45              


Gln Asn 
    50  


<210>  41
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  41

Arg Val Arg Tyr Thr Arg His Thr Pro Glu Asp Lys Leu Lys Lys Ile 
1               5                   10                  15      


Ile Asp Asp Leu Asp Ala Lys Glu His Arg Val Arg Tyr Thr Arg His 
            20                  25                  30          


Thr Pro Glu Asp Lys Leu Lys Lys Ile Ile Asp Asp Leu Asp Ala Lys 
        35                  40                  45              


Glu His 
    50  


<210>  42
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  42

Arg Val Tyr Ile Thr Arg Arg Met Thr Lys Glu Asp Val Glu Lys Ile 
1               5                   10                  15      


Ala Asn Asp Leu Asp Thr Glu Asn His Gly Leu Lys Gln Gln Asn Glu 
            20                  25                  30          


Gln Leu Ser Thr Glu Lys Gln Gly Leu Glu Glu Gln Asn Lys Gln Leu 
        35                  40                  45              


Ser Thr 
    50  


<210>  43
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  43

Asp Arg Val Ser Arg Ser Met Ser Arg Asp Asp Leu Leu Asn Arg Ala 
1               5                   10                  15      


Gln Asp Leu Glu Ala Lys Asn His Gly Leu Glu His Gln Asn Thr Lys 
            20                  25                  30          


Leu Ser Thr Glu Asn Lys Thr Leu Gln Glu Gln Ala Glu Ala Arg Gln 
        35                  40                  45              


Lys Glu 
    50  


<210>  44
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  44

Val Ala Thr Arg Ser Gln Thr Asp Thr Leu Glu Lys Val Gln Glu Arg 
1               5                   10                  15      


Ala Asp Lys Phe Glu Ile Glu Asn Asn Thr Leu Lys Leu Lys Asn Ser 
            20                  25                  30          


Asp Leu Ser Phe Asn Asn Lys Ala Leu Lys Asp His Asn Asp Glu Leu 
        35                  40                  45              


Thr Glu 
    50  


<210>  45
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  45

Glu Gly Val Ser Val Gly Ser Asp Ala Ser Leu His Asn Arg Ile Thr 
1               5                   10                  15      


Asp Leu Glu Glu Glu Arg Glu Lys Leu Leu Asn Lys Leu Asp Lys Val 
            20                  25                  30          


Glu Glu Glu His Lys Lys Asp His Glu Gln Leu Glu Lys Lys Ser Glu 
        35                  40                  45              


Asp Val 
    50  


<210>  46
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  46

Glu Ser Ser Asn Asn Ala Glu Ser Ser Asn Ile Ser Gln Glu Ser Lys 
1               5                   10                  15      


Leu Ile Asn Thr Leu Thr Asp Glu Asn Glu Lys Leu Arg Glu Glu Leu 
            20                  25                  30          


Gln Gln Tyr Tyr Ala Leu Ser Asp Ala Lys Glu Glu Glu Pro Arg Tyr 
        35                  40                  45              


Lys Ala 
    50  


<210>  47
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  47

Asp Asn Gln Ser Pro Ala Pro Val Lys Lys Glu Ala Lys Lys Leu Asn 
1               5                   10                  15      


Glu Ala Glu Leu Tyr Asn Lys Ile Gln Glu Leu Glu Glu Gly Lys Ala 
            20                  25                  30          


Glu Leu Phe Asp Lys Leu Glu Lys Val Glu Glu Glu Asn Lys Lys Val 
        35                  40                  45              


Lys Glu 
    50  


<210>  48
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  48

Asp Ser Asp Asn Ile Asn Arg Ser Val Ser Val Lys Asp Asn Glu Lys 
1               5                   10                  15      


Glu Leu His Asn Lys Ile Ala Asp Leu Glu Glu Glu Arg Gly Glu His 
            20                  25                  30          


Leu Asp Lys Ile Asp Glu Leu Lys Glu Glu Leu Lys Ala Lys Glu Lys 
        35                  40                  45              


Ser Ser 
    50  


<210>  49
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  49

Asp Ser Ser Arg Glu Val Thr Asn Glu Leu Thr Ala Ser Met Trp Lys 
1               5                   10                  15      


Ala Gln Ala Asp Ser Ala Lys Ala Lys Ala Lys Glu Leu Glu Lys Gln 
            20                  25                  30          


Val Glu Glu Tyr Lys Lys Asn Tyr Glu Thr Leu Glu Lys Gly Tyr Asp 
        35                  40                  45              


Asp Leu 
    50  


<210>  50
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  50

Ala Glu Ser Arg Ser Val Ser Gln Gly Ser Val Ser Leu Glu Leu Tyr 
1               5                   10                  15      


Asp Lys Leu Ser Asp Glu Asn Asp Ile Leu Arg Glu Lys Gln Asp Glu 
            20                  25                  30          


Tyr Leu Thr Lys Ile Asp Gly Leu Asp Lys Glu Asn Lys Glu Tyr Ala 
        35                  40                  45              


Ser Gln 
    50  


<210>  51
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  51

Glu Ser Gln Asn Ser Arg Ser Ile Thr Asn Glu Gln Leu Ile Asp Lys 
1               5                   10                  15      


Leu Val Glu Glu Asn Asn Asp Leu Lys Glu Glu Arg Ala Lys Tyr Leu 
            20                  25                  30          


Asp Leu Leu Asp Asn Arg Glu Lys Asp Pro Gln Tyr Arg Ala Leu Met 
        35                  40                  45              


Gly Glu 
    50  


<210>  52
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  52

Ala Glu Lys Lys Val Glu Val Ala Asp Ser Asn Ala Ser Ser Val Ala 
1               5                   10                  15      


Lys Leu Tyr Asn Gln Ile Ala Asp Leu Thr Asp Lys Asn Gly Glu Tyr 
            20                  25                  30          


Leu Glu Arg Ile Glu Glu Leu Glu Glu Arg Gln Lys Asn Leu Glu Lys 
        35                  40                  45              


Leu Glu 
    50  


<210>  53
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  53

Asp Asn Pro Arg Tyr Thr Asp Ala His Asn Ala Val Thr Gln Gly Arg 
1               5                   10                  15      


Thr Val Pro Leu Gln Asn Leu Leu His Glu Met Asp Lys Asn Gly Lys 
            20                  25                  30          


Leu Arg Ser Glu Asn Glu Glu Leu Lys Ala Asp Leu Gln Lys Lys Glu 
        35                  40                  45              


Gln Glu 
    50  


<210>  54
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  54

Asp Ser Ser Ser Arg Asp Ile Thr Glu Ala Gly Val Ser Lys Phe Trp 
1               5                   10                  15      


Lys Ser Lys Phe Asp Ala Glu Gln Asn Arg Ala Asn Glu Leu Glu Lys 
            20                  25                  30          


Lys Leu Ser Gly Tyr Glu Lys Asp Tyr Lys Thr Leu Glu Gln Glu Tyr 
        35                  40                  45              


Glu Asn 
    50  


<210>  55
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  55

Ala Gly Ser Glu Glu Asn Val Pro Lys Gln Gln Tyr Asn Ala Leu Trp 
1               5                   10                  15      


Glu Glu Asn Glu Asp Leu Arg Gly Arg Glu Arg Lys Tyr Ile Ala Lys 
            20                  25                  30          


Leu Glu Lys Glu Glu Ile Gln Asn Gly Glu Leu Asn Glu Lys Asn Arg 
        35                  40                  45              


Lys Leu 
    50  


<210>  56
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  56

Glu Ser Pro Arg Glu Val Thr Asn Glu Leu Ala Ala Ser Val Trp Lys 
1               5                   10                  15      


Lys Lys Val Glu Glu Ala Lys Glu Lys Ala Ser Lys Leu Glu Lys Gln 
            20                  25                  30          


Leu Glu Glu Ala Gln Lys Asp Tyr Ser Glu Ile Glu Gly Lys Leu Glu 
        35                  40                  45              


Gln Phe 
    50  


<210>  57
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  57

Val Glu Lys Lys Val Glu Ala Ala Glu Asn Asn Val Ser Ser Val Ala 
1               5                   10                  15      


Arg Arg Glu Lys Glu Leu Tyr Asp Gln Ile Ala Asp Leu Thr Asp Lys 
            20                  25                  30          


Asn Gly Glu Tyr Leu Glu Arg Ile Gly Glu Leu Glu Glu Arg Gln Lys 
        35                  40                  45              


Asn Leu 
    50  


<210>  58
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  58

Asp Asp Arg Ser Val Ser Thr Asn Ser Gly Ser Val Ser Thr Pro Tyr 
1               5                   10                  15      


Asn Asn Leu Leu Asn Glu Tyr Asp Asp Leu Leu Ala Lys His Gly Glu 
            20                  25                  30          


Leu Leu Ser Glu Tyr Asp Ala Leu Lys Glu Lys Gln Asp Lys Asn Gln 
        35                  40                  45              


Glu Glu 
    50  


<210>  59
<211>  50
<212>  PRT
<213>  Streptococcus pyogenes

<400>  59

Asn Ser Lys Asn Pro Ala Pro Ala Pro Ala Ser Ala Val Pro Val Lys 
1               5                   10                  15      


Lys Glu Ala Thr Lys Leu Ser Glu Ala Glu Leu Tyr Asn Lys Ile Gln 
            20                  25                  30          


Glu Leu Glu Glu Gly Lys Ala Glu Leu Phe Asp Lys Leu Glu Lys Val 
        35                  40                  45              


Glu Glu 
    50  


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag sequence

<400>  60

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag sequence

<400>  61

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


