                         SEQUENCE LISTING

<110>  LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
       ALTMAN, Amnon
       KONG, Kok-Fai
 
<120>  COMPOSITIONS TARGETING PKC-THETA AND USES AND METHODS OF TREATING
        PKC-THETA PATHOLOGIES, ADVERSE IMMUNE RESPONSES AND DISEASES

<130>  051501-0407712

<140>  PCT/US2012/42722
<141>  2012-06-15

<150>  61/497,884
<151>  2011-06-16

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Ser 
1               5                   10                  15      


Cys Gln Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 
            20                  25                  30          


Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 
        35                  40                  45              


Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile 
    50                  55                  60                  


Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val Asp 
65                  70                  75                  80  


Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg Cys 
                85                  90                  95      


Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu Leu Lys Pro Gln 
            100                 105                 110         


Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp Thr 
        115                 120                 125             


Lys Asp Met Asn Glu Phe Glu Thr Glu Gly Phe Phe Ala Leu His Gln 
    130                 135                 140                 


Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His 
145                 150                 155                 160 


Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 
                165                 170                 175     


His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 
            180                 185                 190         


Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys 
        195                 200                 205             


Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys Glu 
    210                 215                 220                 


Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Lys 
225                 230                 235                 240 


Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 
                245                 250                 255     


Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 
            260                 265                 270         


Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 
        275                 280                 285             


Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys Leu 
    290                 295                 300                 


Arg Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu 
305                 310                 315                 320 


Pro Cys Ser Ile Lys Asn Glu Ala Arg Pro Pro Cys Leu Pro Thr Pro 
                325                 330                 335     


Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro Leu Asp Glu 
            340                 345                 350         


Val Asp Lys Met Cys His Leu Pro Glu Pro Glu Leu Asn Lys Glu Arg 
        355                 360                 365             


Pro Ser Leu Gln Ile Lys Leu Lys Ile Glu Asp Phe Ile Leu His Lys 
    370                 375                 380                 


Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys 
385                 390                 395                 400 


Lys Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 
                405                 410                 415     


Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
            420                 425                 430         


Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe 
        435                 440                 445             


Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly Gly 
    450                 455                 460                 


Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser Arg 
465                 470                 475                 480 


Ala Thr Phe Tyr Ala Ala Glu Ile Ile Leu Gly Leu Gln Phe Leu His 
                485                 490                 495     


Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
            500                 505                 510         


Asp Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
        515                 520                 525             


Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 
    530                 535                 540                 


Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val 
545                 550                 555                 560 


Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln 
                565                 570                 575     


Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile Arg 
            580                 585                 590         


Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Lys Glu Ala Lys Asp 
        595                 600                 605             


Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 
    610                 615                 620                 


Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu 
625                 630                 635                 640 


Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 
                645                 650                 655     


Ser Pro Phe Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu Lys 
            660                 665                 670         


Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln 
        675                 680                 685             


Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu Arg Leu 
    690                 695                 700                 


Ile Ser 
705     


<210>  2
<211>  706
<212>  PRT
<213>  Gorilla gorilla

<400>  2

Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Ser 
1               5                   10                  15      


Cys Gln Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 
            20                  25                  30          


Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 
        35                  40                  45              


Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile 
    50                  55                  60                  


Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val Asp 
65                  70                  75                  80  


Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg Cys 
                85                  90                  95      


Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu Leu Lys Pro Gln 
            100                 105                 110         


Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp Thr 
        115                 120                 125             


Lys Asp Met Asn Glu Phe Glu Thr Glu Gly Phe Phe Ala Leu His Gln 
    130                 135                 140                 


Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His 
145                 150                 155                 160 


Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 
                165                 170                 175     


His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 
            180                 185                 190         


Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys 
        195                 200                 205             


Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys Glu 
    210                 215                 220                 


Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Lys 
225                 230                 235                 240 


Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 
                245                 250                 255     


Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 
            260                 265                 270         


Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 
        275                 280                 285             


Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys Leu 
    290                 295                 300                 


Arg Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu 
305                 310                 315                 320 


Pro Cys Ser Ile Lys Asn Glu Ala Arg Pro Pro Cys Leu Pro Thr Pro 
                325                 330                 335     


Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro Leu Asp Glu 
            340                 345                 350         


Val Asp Lys Met Cys His Leu Pro Glu Pro Glu Leu Asn Ile Glu Arg 
        355                 360                 365             


Pro Ser Leu Gln Ile Lys Leu Lys Ile Glu Asp Phe Ile Leu His Lys 
    370                 375                 380                 


Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys 
385                 390                 395                 400 


Lys Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 
                405                 410                 415     


Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
            420                 425                 430         


Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe 
        435                 440                 445             


Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly Gly 
    450                 455                 460                 


Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser Arg 
465                 470                 475                 480 


Ala Thr Phe Tyr Ala Ala Glu Ile Ile Leu Gly Leu Gln Phe Leu His 
                485                 490                 495     


Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
            500                 505                 510         


Asp Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
        515                 520                 525             


Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 
    530                 535                 540                 


Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val 
545                 550                 555                 560 


Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln 
                565                 570                 575     


Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile Arg 
            580                 585                 590         


Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Lys Glu Ala Lys Asp 
        595                 600                 605             


Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 
    610                 615                 620                 


Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu 
625                 630                 635                 640 


Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 
                645                 650                 655     


Ser Pro Phe Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu Lys 
            660                 665                 670         


Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln 
        675                 680                 685             


Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu Arg Leu 
    690                 695                 700                 


Ile Ser 
705     


<210>  3
<211>  706
<212>  PRT
<213>  Pan troglodytes

<400>  3

Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Ser 
1               5                   10                  15      


Cys Gln Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 
            20                  25                  30          


Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 
        35                  40                  45              


Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile 
    50                  55                  60                  


Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val Asp 
65                  70                  75                  80  


Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg Cys 
                85                  90                  95      


Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu Leu Lys Pro Gln 
            100                 105                 110         


Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp Thr 
        115                 120                 125             


Lys Asp Met Asn Glu Phe Glu Thr Glu Gly Phe Phe Ala Leu His Gln 
    130                 135                 140                 


Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His 
145                 150                 155                 160 


Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 
                165                 170                 175     


His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 
            180                 185                 190         


Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys 
        195                 200                 205             


Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys Glu 
    210                 215                 220                 


Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Lys 
225                 230                 235                 240 


Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 
                245                 250                 255     


Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 
            260                 265                 270         


Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 
        275                 280                 285             


Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys Leu 
    290                 295                 300                 


Arg Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu 
305                 310                 315                 320 


Pro Cys Ser Ile Lys Asn Glu Ala Arg Pro Pro Cys Leu Pro Thr Leu 
                325                 330                 335     


Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro Leu Asp Glu 
            340                 345                 350         


Val Asp Lys Met Cys His Leu Pro Glu Pro Glu Leu Asn Ile Glu Arg 
        355                 360                 365             


Pro Ser Leu Gln Ile Lys Leu Lys Ile Glu Asp Phe Ile Leu His Lys 
    370                 375                 380                 


Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys 
385                 390                 395                 400 


Lys Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 
                405                 410                 415     


Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
            420                 425                 430         


Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe 
        435                 440                 445             


Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly Gly 
    450                 455                 460                 


Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser Arg 
465                 470                 475                 480 


Ala Thr Phe Tyr Ala Ala Glu Ile Ile Leu Gly Leu Gln Phe Leu His 
                485                 490                 495     


Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
            500                 505                 510         


Asp Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
        515                 520                 525             


Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 
    530                 535                 540                 


Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val 
545                 550                 555                 560 


Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln 
                565                 570                 575     


Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile Arg 
            580                 585                 590         


Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Lys Glu Ala Lys Asp 
        595                 600                 605             


Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 
    610                 615                 620                 


Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu 
625                 630                 635                 640 


Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 
                645                 650                 655     


Ser Pro Phe Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu Lys 
            660                 665                 670         


Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln 
        675                 680                 685             


Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu Arg Leu 
    690                 695                 700                 


Ile Ser 
705     


<210>  4
<211>  706
<212>  PRT
<213>  Pongo borneo

<400>  4

Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Ser 
1               5                   10                  15      


Cys Gln Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 
            20                  25                  30          


Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 
        35                  40                  45              


Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile 
    50                  55                  60                  


Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val Asp 
65                  70                  75                  80  


Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg Cys 
                85                  90                  95      


Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu Leu Lys Pro Gln 
            100                 105                 110         


Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp Thr 
        115                 120                 125             


Lys Asp Met Ser Glu Phe Glu Met Glu Gly Phe Phe Ala Leu His Gln 
    130                 135                 140                 


Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His 
145                 150                 155                 160 


Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 
                165                 170                 175     


His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 
            180                 185                 190         


Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys 
        195                 200                 205             


Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys Glu 
    210                 215                 220                 


Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Lys 
225                 230                 235                 240 


Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 
                245                 250                 255     


Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 
            260                 265                 270         


Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 
        275                 280                 285             


Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys Leu 
    290                 295                 300                 


Arg Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu 
305                 310                 315                 320 


Pro Cys Ser Ile Lys Asn Glu Ala Arg Pro Leu Cys Leu Pro Thr Pro 
                325                 330                 335     


Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro Leu Asp Glu 
            340                 345                 350         


Val Asp Lys Met Cys His Leu Pro Glu Pro Glu Leu Thr Ile Glu Arg 
        355                 360                 365             


Pro Ser Leu Gln Met Lys Leu Lys Ile Glu Asp Phe Ile Leu His Lys 
    370                 375                 380                 


Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys 
385                 390                 395                 400 


Lys Thr Asn Gln Phe Phe Ala Ile Lys Thr Leu Lys Lys Asp Val Val 
                405                 410                 415     


Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
            420                 425                 430         


Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe 
        435                 440                 445             


Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly Gly 
    450                 455                 460                 


Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser Arg 
465                 470                 475                 480 


Ala Thr Phe Tyr Ala Ala Glu Ile Ile Leu Gly Leu Gln Phe Leu His 
                485                 490                 495     


Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
            500                 505                 510         


Asp Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
        515                 520                 525             


Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 
    530                 535                 540                 


Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val 
545                 550                 555                 560 


Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln 
                565                 570                 575     


Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile Arg 
            580                 585                 590         


Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Lys Glu Ala Lys Asp 
        595                 600                 605             


Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 
    610                 615                 620                 


Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu 
625                 630                 635                 640 


Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 
                645                 650                 655     


Ser Pro Tyr Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu Lys 
            660                 665                 670         


Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln 
        675                 680                 685             


Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu Arg Leu 
    690                 695                 700                 


Ile Ser 
705     


<210>  5
<211>  739
<212>  PRT
<213>  Simia Inuus

<400>  5

Met Ile Lys His Trp Leu Ser Arg Arg Gly Thr Pro Lys Thr Val Pro 
1               5                   10                  15      


Phe Ile Ala Pro Lys Gln His Leu Ser Cys Val Val Phe Gln Gly Ala 
            20                  25                  30          


Thr Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly 
        35                  40                  45              


Ser Cys Gln Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val 
    50                  55                  60                  


Leu Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln 
65                  70                  75                  80  


Lys Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His 
                85                  90                  95      


Ile Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val 
            100                 105                 110         


Asp Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg 
        115                 120                 125             


Cys Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu Leu Lys Pro 
    130                 135                 140                 


Gln Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp 
145                 150                 155                 160 


Thr Lys Asp Met Ser Glu Phe Glu Thr Glu Gly Phe Phe Ala Leu His 
                165                 170                 175     


Gln Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys 
            180                 185                 190         


His Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val 
        195                 200                 205             


Cys His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg 
    210                 215                 220                 


Gln Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala 
225                 230                 235                 240 


Lys Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys 
                245                 250                 255     


Glu Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr 
            260                 265                 270         


Lys Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu 
        275                 280                 285             


Ala Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His 
    290                 295                 300                 


Arg Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu 
305                 310                 315                 320 


Met Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys 
                325                 330                 335     


Leu Arg Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly 
            340                 345                 350         


Leu Pro Cys Ser Thr Lys Asn Glu Ala Arg Pro Pro Cys Leu Pro Thr 
        355                 360                 365             


Pro Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro Leu Asp 
    370                 375                 380                 


Glu Val Asp Lys Met Cys His Leu Pro Glu Pro Glu Leu Asn Lys Glu 
385                 390                 395                 400 


Arg Pro Ser Leu Gln Met Lys Leu Lys Ile Glu Asp Phe Ile Leu His 
                405                 410                 415     


Lys Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe 
            420                 425                 430         


Lys Lys Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val 
        435                 440                 445             


Val Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val 
    450                 455                 460                 


Leu Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr 
465                 470                 475                 480 


Phe Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly 
                485                 490                 495     


Gly Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser 
            500                 505                 510         


Arg Ala Thr Phe Tyr Ala Ala Glu Ile Ile Leu Gly Leu Gln Phe Leu 
        515                 520                 525             


His Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu 
    530                 535                 540                 


Leu Asp Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys 
545                 550                 555                 560 


Glu Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro 
                565                 570                 575     


Asp Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Arg Tyr Asn His Ser 
            580                 585                 590         


Val Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly 
        595                 600                 605             


Gln Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile 
    610                 615                 620                 


Arg Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Lys Glu Ala Lys 
625                 630                 635                 640 


Asp Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly 
                645                 650                 655     


Val Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp 
            660                 665                 670         


Glu Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val 
        675                 680                 685             


Lys Ser Pro Tyr Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu 
    690                 695                 700                 


Lys Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp 
705                 710                 715                 720 


Gln Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu Arg 
                725                 730                 735     


Leu Ile Ser 
            


<210>  6
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  7
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  8
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 
        35                  40                  45              


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    50                  55                  60                  


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
65                  70                  75                  80  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                85                  90                  95      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            100                 105                 110         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120             


<210>  9
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Arg Pro Pro Cys Leu Pro Thr Pro 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Pan troglodytes

<400>  11

Ala Arg Pro Pro Cys Leu Pro Thr Leu 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Macaca mulatto

<400>  12

Ala Arg Pro Pro Cys Leu Pro Thr Pro 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  13

Ala Arg Leu Pro Cys Val Pro Ala Pro 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Felis catus

<400>  14

Ala Arg Leu Pro Cys Val Pro Ala Ser 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Equus cabal/us

<400>  15

Ala Lys Leu Pro His Ala Pro Ala Pro 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Bos taurus

<400>  16

Ala Lys Pro Pro Tyr Val Pro Gly Pro 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Loxodonta africana

<400>  17

Thr Arg Leu Pro Tyr Leu Pro Thr Pro 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Ailuropoda melanoleuca

<400>  18

Ala Lys Leu Pro Cys Val Pro Ala Pro 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  19

Thr Arg Pro Pro Cys Val Pro Thr Pro 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Thr Arg Pro Pro Cys Val Pro Thr Pro 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Ochotona princeps

<400>  21

Thr Arg Pro Pro Tyr Leu Pro Thr Pro 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Dipodomys ordii

<400>  22

Thr Arg Gln Pro Asn Phe Pro Thr Pro 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Spermophilus tridecemlineatus

<400>  23

Ala Arg Pro Pro Tyr Leu Pro Thr Pro 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Tupaia belangeri

<400>  24

Ala Arg Ser Pro Tyr Leu Pro Thr Pro 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Procavia capensis

<400>  25

Thr Arg Leu Pro Tyr Leu Pro Thr Pro 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Echinops telfairi

<400>  26

Thr Lys Leu Pro Tyr Leu Pro Ala Pro 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Cavia porcellus

<400>  27

Ala Arg Leu Pro Tyr Leu Pro Thr Gly 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Dasypus novemcinctus

<400>  28

Thr Arg Leu Pro Tyr Leu Pro Val Pro 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Pteropus vampyrus

<400>  29

Ala Arg Pro Pro His Gly Pro Ala Leu 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Tursiops truncatus

<400>  30

Ala Lys Leu Pro Tyr Gly Pro Ala Pro 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Xenopus laevis

<400>  31

Pro Lys Ala Pro Gly Leu Pro Met Pro 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Danio rerio

<400>  32

Ala Ile Ser Pro Leu Thr Pro Ala Pro 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Tetraodon nigroviridis

<400>  33

Leu Leu Leu Pro Asn Leu Pro Leu Pro 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Takifugu rubripses

<400>  34

Val Arg Ala Pro Ser Gly Pro Ile Thr 
1               5                   


<210>  35
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  35

Glu Thr Arg Pro Pro Cys Val Pro Thr Pro Gly Lys 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Polyglycine linker

<400>  36

Leu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10          


<210>  37
<211>  16
<212>  PRT
<213>  Drosophila antennapedia

<400>  37

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Cell-penetrating peptide

<400>  38

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Cell-penetrating peptide

<400>  39

Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Cell-penetrating peptide

<400>  40

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  41
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Cell-penetrating peptide

<400>  41

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Cell-penetrating peptide

<400>  42

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu 
            20                  25                  


<210>  43
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Cell-penetrating peptide

<400>  43

Arg Arg Arg Arg Arg Arg Arg Arg Arg Glu Thr Arg Pro Pro Cys Val 
1               5                   10                  15      


Pro Thr Pro Gly Lys 
            20      


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Cell-penetrating peptide

<400>  44

Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Thr Val Gly Pro Lys Glu 
1               5                   10                  15      


Arg Pro Cys Pro Thr 
            20      


